Aliases & Classifications for Appendicitis

MalaCards integrated aliases for Appendicitis:

Name: Appendicitis 12 52 41 42 14 69
Acute Appendicitis 12 52
Acute Appendicitis with Generalized Peritonitis 12
Acute Appendicitis with Peritoneal Abscess 12
Acute Appendicitis Nos 69

Classifications:



External Ids:

Disease Ontology 12 DOID:8337
ICD9CM 35 540-543.99 541
MeSH 42 D001064
NCIt 47 C35145
UMLS 69 C0003615

Summaries for Appendicitis

MedlinePlus : 41 the appendix is a small, tube-like organ attached to the first part of the large intestine. it is located in the lower right part of the abdomen. it has no known function. a blockage inside of the appendix causes appendicitis. the blockage leads to increased pressure, problems with blood flow, and inflammation. if the blockage is not treated, the appendix can burst and spread infection into the abdomen. this causes a condition called peritonitis. the main symptom is pain in the abdomen, often on the right side. it is usually sudden and gets worse over time. other symptoms may include swelling in the abdomen loss of appetite nausea and vomiting constipation or diarrhea inability to pass gas low fever not everyone with appendicitis has all these symptoms. appendicitis is a medical emergency. treatment almost always involves removing the appendix. anyone can get appendicitis, but it is more common among people 10 to 30 years old. nih: national institute of diabetes and digestive and kidney diseases

MalaCards based summary : Appendicitis, also known as acute appendicitis, is related to polyarteritis nodosa and basidiobolomycosis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Appendicitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Ertapenem and Metronidazole have been mentioned in the context of this disorder. Affiliated tissues include appendix, kidney and colon, and related phenotypes are cardiovascular system and hematopoietic system

Disease Ontology : 12 A gastrointestinal system infectious disease that involves inflammation and infection of the appendix caused by the blockage of the lumen with a small, hard piece of stool, a foreign body or worms. Mucus backs up in the appendiceal lumen, causing bacteria that live inside the appendix to multiply. The infection has symptom pain, in the upper abdomen initially and later in the lower abdomen, has symptom nausea, has symptom vomiting and has symptom fever.

Wikipedia : 72 Appendicitis is inflammation of the appendix. Symptoms commonly include right lower abdominal pain,... more...

Related Diseases for Appendicitis

Diseases related to Appendicitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 512)
id Related Disease Score Top Affiliating Genes
1 polyarteritis nodosa 29.9 ALB CRP TNF
2 basidiobolomycosis 29.8 CXCL8 IL10 TNF
3 myopathy 29.8 CXCL8 MMP9 TNF
4 human monocytic ehrlichiosis 29.8 IL1B IL6 TNF
5 ulcerative colitis 29.5 ENO2 IL10 IL6 TNF
6 noma 29.4 IL10 IL1B IL6 TNF
7 lymphoma 29.4 ALB IL10 IL1B IL6 TNF
8 acute pancreatitis 29.4 CXCL8 IL1B IL6
9 myeloid sarcoma 29.4 CRP CXCL8 IL1B IL6 TNF
10 adenocarcinoid tumor 29.4 CXCL8 IL6 LBP TNF
11 churg-strauss syndrome 29.3 CXCL8 IL10 IL1B TNF
12 autoimmune hepatitis 29.3 CRP IL1B MMP9 TNF
13 pyelonephritis 29.2 CRP CXCL8 IL10 IL1B TNF
14 pulmonary embolism 27.5 ALB CRP CXCL8 IL10 IL1B IL6
15 peritonitis 11.2
16 pseudomyxoma peritonei 11.1
17 goblet cell carcinoid 11.1
18 collagenopathy type 2 alpha 1 10.8 CRP IL6
19 smarca4-deficient sarcoma of thorax 10.8 IL6 TNF
20 crystal arthropathies 10.8 CRP IL6
21 aortic arch interruption 10.8 IL6 TNF
22 pure autonomic failure 10.8 IL10 TNF
23 shoulder impingement syndrome 10.8 CRP IL6
24 cutaneous leishmaniasis 10.8 IL6 TNF
25 brachydactyly-distal symphalangism syndrome 10.8 CRP IL6
26 acute ackee fruit intoxication 10.7 IL10 TNF
27 ichthyosis, congenital, autosomal recessive 12 10.7 CXCL8 MMP9
28 epstein-barr virus hepatitis 10.7 CRP IL6 TNF
29 tabatznik syndrome 10.7 IL1B TNF
30 toxic optic neuropathy 10.7 IL1B MMP9
31 sternal cleft 10.7 IL1B TNF
32 multiple familial trichoepithelioma 10.7 IL10 TNF
33 peroneal nerve paralysis 10.7 IL10 IL6
34 islet cell tumor 10.7 CRP IL6 TNF
35 small cell lung cancer, adult 10.7 CRP CXCL8
36 toxoplasmosis 10.7 IL6 TNF
37 placental abruption 10.7 CRP IL6 TNF
38 lagophthalmos 10.7 IL10 TNF
39 early congenital syphilis 10.6 CRP IL6 TNF
40 petrous apex meningioma 10.6 CRP MMP9 TNF
41 spirillary rat-bite fever 10.6 CXCL8 IL6 TNF
42 common variable immunodeficiency 10.6 MMP9 TIMP1
43 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.6 CRP IL10 IL6
44 x-linked dominant intellectual disability-epilepsy syndrome 10.6 CRP IL1B IL6
45 pasteurellosis 10.6 CXCL8 IL6 TNF
46 pneumoconiosis 10.6 CRP CXCL8 IL6
47 pityriasis rosea 10.6 IL6 MMP9 TNF
48 pulmonary hypertension 10.6 IL1B TNF
49 congenital dyserythropoietic anemia 10.6 ALB TNF
50 ethmoid sinus adenocarcinoma 10.6 IL10 IL6 TNF

Graphical network of the top 20 diseases related to Appendicitis:



Diseases related to Appendicitis

Symptoms & Phenotypes for Appendicitis

UMLS symptoms related to Appendicitis:


abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Appendicitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.02 CD19 CRP IL10 IL1B IL6 MMP9
2 hematopoietic system MP:0005397 9.96 TIMP1 TNF CD19 IL10 IL1B IL6
3 homeostasis/metabolism MP:0005376 9.93 ALB CD19 CRP DMBT1 IL10 IL1B
4 digestive/alimentary MP:0005381 9.87 ALB CD19 DMBT1 IL10 IL6 MMP9
5 immune system MP:0005387 9.73 IL10 IL1B IL6 LBP MMP9 MPO
6 neoplasm MP:0002006 9.28 ALB CD19 DMBT1 IL10 IL1B IL6

Drugs & Therapeutics for Appendicitis

Drugs for Appendicitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 167)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ertapenem Approved, Investigational Phase 4,Phase 2,Early Phase 1 153832-46-3 150610
2
Metronidazole Approved Phase 4,Phase 3,Phase 2,Early Phase 1 443-48-1 4173
3
Menthol Approved Phase 4,Phase 2 2216-51-5 16666
4
Ampicillin Approved, Vet_approved Phase 4 69-53-4 6249
5
Ceftriaxone Approved Phase 4 73384-59-5 5479530 5361919
6
Ceftazidime Approved Phase 4 78439-06-2, 72558-82-8 5481173
7
Clindamycin Approved, Vet_approved Phase 4 18323-44-9 29029
8
Morphine Approved, Investigational Phase 4,Phase 1,Phase 2 57-27-2 5288826
9
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
10
Bupivacaine Approved, Investigational Phase 4,Phase 2 2180-92-9, 38396-39-3 2474
11
Ropivacaine Approved Phase 4,Phase 1,Phase 2 84057-95-4 71273 175805
12
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
13
Minocycline Approved, Investigational Phase 4 10118-90-8 5281021
14
Tigecycline Approved Phase 4 220620-09-7 5282044
15
Piperacillin Approved Phase 4 66258-76-2 43672
16
Tazobactam Approved Phase 4 89786-04-9 123630
17
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
18
Levofloxacin Approved, Investigational Phase 4,Phase 2 100986-85-4 149096
19
Ofloxacin Approved Phase 4,Phase 2 82419-36-1 4583
20 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Early Phase 1
21 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Early Phase 1
22 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Early Phase 1
23 Antitubercular Agents Phase 4,Phase 3,Phase 2,Early Phase 1
24 Antiparasitic Agents Phase 4,Phase 3,Phase 2,Early Phase 1
25 Antiprotozoal Agents Phase 4,Phase 3,Phase 2,Early Phase 1
26 Gentamicins Phase 4
27 Clindamycin palmitate Phase 4
28 Clindamycin phosphate Phase 4
29 Analgesics Phase 4,Phase 3
30 Analgesics, Opioid Phase 4,Phase 3
31 Central Nervous System Depressants Phase 4,Phase 3,Phase 1,Phase 2
32 Narcotics Phase 4,Phase 3
33 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
34 beta-Lactamase Inhibitors Phase 4,Phase 3,Phase 2
35 Clavulanic Acid Phase 4,Phase 3,Phase 2
36 Anesthetics Phase 4,Phase 3,Phase 1,Phase 2
37 Anesthetics, Local Phase 4,Phase 1,Phase 2
38 Analgesics, Non-Narcotic Phase 4,Phase 3
39 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
40 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3
41 Antirheumatic Agents Phase 4,Phase 3
42 Cyclooxygenase 2 Inhibitors Phase 4
43 Cyclooxygenase Inhibitors Phase 4,Phase 3
44 Amoxicillin-Potassium Clavulanate Combination Phase 4,Phase 3,Phase 2
45 Adrenergic Agents Phase 4
46 Adrenergic Agonists Phase 4
47 Adrenergic alpha-Agonists Phase 4
48 Neurotransmitter Agents Phase 4
49 Cytochrome P-450 CYP1A2 Inhibitors Phase 4,Phase 2
50 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show top 50) (show all 191)

id Name Status NCT ID Phase Drugs
1 Antibiotics Versus Surgery in Acute Appendicitis Unknown status NCT01421901 Phase 4 Ertapenem
2 Safety and Efficacy of Single Daily Dose of Ceftriaxone and Metronidazole for Treatment of Complicated Appendicitis in Children Completed NCT01678365 Phase 4 ceftriaxone, metronidazole/ampicillin, gentamicin, and metronidazole
3 Prospective Randomized Evaluation of Antibiotic Regimen Following Appendectomy for Perforated Appendicitis Completed NCT00195923 Phase 4 Ampicillin, gentamicin, clindamycin, flagyl, ceftazidime
4 Effect of Pain Control on the Diagnosis of Acute Appendicitis on the Diagnostic Accuracy of General Surgeon Completed NCT00783016 Phase 4 Morphine
5 Morphine Analgesia in Patients With Acute Appendicitis Completed NCT00477061 Phase 4 Morphine
6 Non Operative Treatment for Acute Appendicitis Completed NCT01096927 Phase 4 Amoxicillin and Clavulanic Acid
7 A Comparison of UGBRS Block and Local Infiltration Completed NCT02352519 Phase 4
8 Laparoscopic Versus Open Appendectomy Completed NCT02867072 Phase 4
9 Appendicectomy Skin Closure Technique: Changing Paradigms (ASC) Completed NCT02625987 Phase 4
10 Wound Healing After Emergency Appendicectomy Completed NCT00913445 Phase 4
11 Choose the Best Concentration of Ropivacaine on TAP Block for Open Appendectomy in Children Completed NCT03005808 Phase 4 Ropivacaine
12 Wound Infection Alexis Wound Retractor Completed NCT00323453 Phase 4
13 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
14 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
15 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
16 Initial Non-operative Treatment Strategy Versus Appendectomy Treatment Strategy for Simple Appendicitis in Children Recruiting NCT02848820 Phase 4 Augmentin + Gentamicin
17 Intraperitoneal Dexmedetomidine for Post-laparoscopic Appendicectomy Pain Management in Children Recruiting NCT03067740 Phase 4 Bupivacaine;Dexmedetomidine
18 A Study Comparing Safety and Efficacy of Levofloxacin and Metronidazole Versus Piperacillin/Tazobactam in Treating Complicated Appendicitis Terminated NCT00236912 Phase 4 levofloxacin; metronidazole
19 Study Comparing Early Laparoscopy With Active Observation in Acute Non-specific Abdominal Pain Terminated NCT01675466 Phase 4
20 Once Daily Metronidazole for Perforated Appendicitis Withdrawn NCT02561117 Phase 4 Metronidazole
21 Cefoperazone/Sulbactam In The Treatment Of Serious Intra-Abdominal And Hepatobiliary Infections. Withdrawn NCT00463762 Phase 4 CP-75385-02 Cefoperazone/sulbactam
22 Laparoscopic Appendectomy by Multi-port vs Single Port. Unknown status NCT01720082 Phase 3
23 Feasibility of Outpatient Appendectomy for Acute Appendicitis Completed NCT01839435 Phase 3
24 Early Versus Interval Appendectomy for Ruptured Appendicitis in Children Completed NCT00435032 Phase 3
25 Efficacy Study of Delayed Primary Closure to Reduce Rate of Wound Infection in Complicated Appendicitis Completed NCT01659983 Phase 3
26 Diagnosis of Acute Appendicitis: Low-dose Computed Tomography (CT) Versus Standard-dose CT Completed NCT00913380 Phase 3
27 Antibiotic Prophylaxis in the Prevention of Surgical Site Infections After Selected Urgent Abdominal Surgical Procedures Completed NCT01524081 Phase 3 Metronidazole, Cefuroxime;Amoxicillin (+ clavulanic acid) and Fluconazole;Placebo;Placebo
28 Laparoscopic Appendectomy for Chronic Right Lower Abdominal Pain Completed NCT00413855 Phase 3
29 Single Incision Versus Conventional Laparoscopic Appendectomy Completed NCT01515293 Phase 3
30 A Randomised Controlled Trial on LESS Versus Conventional Laparoscopic Appendicectomy. Completed NCT01203566 Phase 3
31 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
32 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
33 Sublingual Analgesia for Acute Abdominal Pain in Children Completed NCT02465255 Phase 3 Ketorolac;Tramadol;Acetaminophen
34 Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Active, not recruiting NCT02784704 Phase 3 Eravacycline;Meropenem;Placebo
35 The Onset Time of Rocuronium in Emergency and Elective Surgery Not yet recruiting NCT02634255 Phase 3 Rocuronium elective surgery;Rocuronium emergency surgery;Propofol;Fentanyl
36 A Safety and Tolerability Study of Doripenem Compared With Meropenem in Children Hospitalized With Complicated Intra-abdominal Infections Terminated NCT01110382 Phase 3 Doripenem;Meropenem placebo;Meropenem;Doripenem placebo;Amoxicillin/clavulanate potassium
37 Perforated Appendicitis With Delayed Presentation Unknown status NCT01068288 Phase 2
38 Study of Conservative Versus Surgical Treatment of Appendicitis Completed NCT00469430 Phase 2 cefotaxim and metronidazol
39 Preoperative Methylprednisolone to Patients Suspected of Appendicitis Undergoing Laparoscopy Completed NCT02711449 Phase 2 Methylprednisolone;0.9% Saline
40 Dexamethasone Preoperative for Patients Undergoing Laparoscopy for Suspected Appendicitis Completed NCT02415335 Phase 2 dexamethasone phosphate;Isotonic NaCl
41 Laparoscopic Management of Periappendicular Abscess Completed NCT01283815 Phase 2
42 Conservative Versus Operative ManageMent of Acute Uncomplicated Appendicitis Recruiting NCT02916134 Phase 2 Antibiotic treatment
43 Dilute Povidone-iodine Irrigation vs No Irrigation for Children With Acute, Perforated Appendicitis Recruiting NCT02664220 Phase 2 Povidone-iodine irrigation
44 The Safety and Pharmacokinetics of Intraperitoneal Administration in Patients Undergoing Appendectomy for Uncomplicated Appendicitis Recruiting NCT03046758 Phase 2 A combination of fosfomycin, metronidazole and GM-CSF i.p.
45 Nebulized Analgesia for Laparoscopic Appendectomy Trial Recruiting NCT02624089 Phase 1, Phase 2 Ropivacaine;Normal saline
46 Clinical Trial Comparing ERAT vs Antibiotic Therapy vs Appendectomy for Treatment of Uncomplicated Acute Appendicitis Not yet recruiting NCT02789865 Phase 2 Ertapenem, Levofloxacin and Metronidazole
47 Transversus Abdominis Plane (TAP) Versus Local Anesthetic for Lap Appendectomies Terminated NCT01575028 Phase 2 Ropivacaine;Bupivacaine
48 Trial on Postoperative Outcomes According to the Number of Trocar During Laparoscopic Appendectomy Unknown status NCT00816933 Phase 1
49 Contrast-Enhanced Ultrasound Diagnosis of Acute Appendicitis Not yet recruiting NCT03295656 Phase 1 Sulfur hexafluoride lipid-type A microspheres
50 Pediatric Appendicitis Pathway Study Unknown status NCT01192620

Search NIH Clinical Center for Appendicitis

Cochrane evidence based reviews: appendicitis

Genetic Tests for Appendicitis

Anatomical Context for Appendicitis

MalaCards organs/tissues related to Appendicitis:

39
Appendix, Kidney, Colon, Testes, Liver, Neutrophil, Ovary

Publications for Appendicitis

Articles related to Appendicitis:

(show top 50) (show all 996)
id Title Authors Year
1
Circulating human leucine-rich I+-2-glycoprotein 1 mRNA and protein levels to detect acute appendicitis in patients with acute abdominal pain. ( 28202345 )
2017
2
Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Contrasting Interpretations of Data. ( 28938269 )
2017
3
How to differentiate acute pelvic inflammatory disease from acute appendicitis ? A decision tree based on CT findings. ( 28894927 )
2017
4
Increased incidence of bowel cancer after non-surgical treatment of appendicitis. ( 28942236 )
2017
5
Focused CT using a height-adjusted metric and the umbilicus as a landmark for children undergoing evaluation for appendicitis. ( 28062934 )
2017
6
Gastrointestinal: Pneumoperitoneum caused by acute perforated appendicitis. ( 28052460 )
2017
7
Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy. ( 28932077 )
2017
8
Dual versus Triple Antibiotics Regimen in Children with Perforated Acute Appendicitis. ( 28946163 )
2017
9
Perforation of Meckel's diverticulum with a foreign body mimicking acute appendicitis: A rare complication. ( 28585600 )
2017
10
Reply to: The letter to the editor "Antibiotics vs. Surgical Therapy for Uncomplicated Appendicitis: Contrasting Interpretations of Data" by McAnena et al. ( 28938267 )
2017
11
Immunoproteasome in the of children with acute appendicitis, and its correlation with proteasome and UCHL1 measured by SPR imaging biosensors. ( 28940383 )
2017
12
Randomized clinical trial of preoperative dexamethasone on postoperative nausea and vomiting after laparoscopy for suspected appendicitis. ( 28072446 )
2017
13
Sonographic Differentiation of Complicated From Uncomplicated Appendicitis: Implications for Antibiotics-First Therapy. ( 28039865 )
2017
14
Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis. ( 28925502 )
2017
15
The Accuracy of The Computed Tomography Diagnosis of Acute Appendicitis: Does The Experience of The Radiologist Matter? ( 28929862 )
2017
16
Value of Leucine-rich alpha-2-glycoprotein-1 (LRG-1) on diagnosis of acute appendicitis in female patients with right lower-quadrant abdominal pain. ( 28924279 )
2017
17
Imaging is Usually Not Necessary When Clinical Scores for the Diagnosis of Appendicitis Are Low. ( 28005500 )
2017
18
Cocoon Peritonitis Secondary to Perforated Appendicitis. ( 28894520 )
2017
19
Perforated appendicitis in patients with schizophrenia: a retrospective cohort study. ( 28951411 )
2017
20
Acute Appendicitis: An Extracolonic Manifestation of Clostridium difficile Colitis. ( 28757875 )
2017
21
A rare case: Retrocecal appendicitis adherent to the liver capsule. ( 28944342 )
2017
22
Right iliac vein thrombosis mimicking acute appendicitis in pregnancy: a case report. ( 28057056 )
2017
23
Neonatal Appendicitis as a Rare Cause of Intestinal Perforation in a Preterm Neonate. ( 28302241 )
2017
24
Characteristics of mesenteric lymphadenitis in comparison with those of acute appendicitis in children. ( 27987102 )
2017
25
Biomarkers to estimate the probability of complicated appendicitis. ( 28951011 )
2017
26
Outpatient laparoscopic appendectomy can be successfully performed for uncomplicated appendicitis: A Southwestern Surgical Congress Multicenter Trial. ( 28943063 )
2017
27
Antibiotics Versus Appendicectomy for the Treatment of Uncomplicated Acute Appendicitis: An Updated Meta-Analysis of Randomised Controlled Trials by Rollins et al. ( 28050666 )
2017
28
Isolation of Shewanella putrefaciens in an elderly man with subacute intestinal obstruction & appendicitis. ( 28649508 )
2017
29
Acute Appendicitis, Somatosensory Disturbances ("Head Zones"), and the Differential Diagnosis of Anterior Cutaneous Nerve Entrapment Syndrome (ACNES). ( 28411350 )
2017
30
Approaching zero: Implications of a computed tomography reduction program for pediatric appendicitis evaluation. ( 28927978 )
2017
31
Standardization of care for pediatric perforated appendicitis improves outcomes. ( 28935397 )
2017
32
Delayed presentation of uterine rupture in a didelphys uterus misdiagnosed as appendicitis: a case report and review of the literature. ( 28900659 )
2017
33
Evaluation of the Alvarado scoring system in the management of acute appendicitis. ( 28944334 )
2017
34
Incarcerated recurrent inguinal hernia containing an acute appendicitis (Amyand hernia): an extremely rare surgical situation. ( 28507592 )
2017
35
Non-operative management of uncomplicated acute appendicitis in children: where is the evidence? ( 28939636 )
2017
36
Appendicitis Caused by Primary Varicella Zoster Virus Infection in a Child with DiGeorge Syndrome. ( 28900551 )
2017
37
Operative versus non-operative management in the care of patients with complicated appendicitis. ( 28941724 )
2017
38
Second date appendectomy: Operating for failure of nonoperative treatment in perforated appendicitis. ( 28063718 )
2017
39
A rare case of subacute appendicitis, actinomycosis as the final pathology reports: A case report and literature review. ( 28531869 )
2017
40
Nonoperative Management of Appendicitis. ( 28952357 )
2017
41
Acute appendicitis due to schistosomiasis: four cases at the Yalgado OuAcdraogo University Hospital of Ouagadougou. ( 28947413 )
2017
42
An unusual cause of acute appendicitis in New Zealand. ( 28081559 )
2017
43
Diagnostic accuracy of fibrinogen to differentiate appendicitis from nonspecific abdominal pain in children. ( 27760719 )
2017
44
Recovery and convalescence after laparoscopic surgery for appendicitis: A longitudinal cohort study. ( 27664890 )
2016
45
Reduced risk of UC in families affected by appendicitis: a Danish national cohort study. ( 27196591 )
2016
46
Neutrophil-to-lymphocyte count ratio is associated with perforated appendicitis in elderly patients of emergency department. ( 27216860 )
2016
47
Gangrenous appendicitis in a patient with severe congenital neutropenia. ( 27804250 )
2016
48
Comparison of clinical outcome of laparoscopic versus open appendectomy for complicated appendicitis. ( 27194260 )
2016
49
Amyand's hernia with appendicitis masquerading as Fournier's gangrene: a case report and review of the literature. ( 27658707 )
2016
50
Inflammatory myofibroblastic tumor of the small intestine mimicking acute appendicitis: a case report and review of the literature. ( 27094797 )
2016

Variations for Appendicitis

Expression for Appendicitis

Search GEO for disease gene expression data for Appendicitis.

Pathways for Appendicitis

Pathways related to Appendicitis according to GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.02 CD19 CRP CXCL8 IL10 IL1B IL6
2
Show member pathways
13.39 CXCL8 IL10 IL1B IL6 RHOH TIMP1
3
Show member pathways
13.36 CXCL8 IL10 IL1B IL6 LBP MMP9
4
Show member pathways
13.3 CXCL8 IL10 IL1B IL6 RHOH TIMP1
5
Show member pathways
12.88 CXCL8 IL10 IL1B IL6 LBP TNF
6
Show member pathways
12.84 CXCL8 IL10 IL1B IL6 TNF
7
Show member pathways
12.59 IL10 IL1B IL6 MPO TIMP1 TNF
8 12.57 CD19 IL10 IL1B MPO TNF
9
Show member pathways
12.42 IL10 IL1B IL6 TNF
10
Show member pathways
12.35 CXCL8 IL1B IL6 MMP9 TNF
11
Show member pathways
12.29 CXCL8 IL1B IL6 LBP TNF
12 12.26 IL10 IL1B IL6 LBP TNF
13 12.25 CXCL8 IL6 MMP9 MPO
14
Show member pathways
12.21 CXCL8 IL1B IL6 LBP TNF
15 12.19 CXCL8 IL10 IL1B IL6 TNF
16
Show member pathways
12.16 CXCL8 IL10 IL1B IL6 TNF
17 12.01 CXCL8 IL1B IL6 MMP9 TNF
18 12 IL1B IL6 MMP9 TNF
19
Show member pathways
11.99 IL10 IL1B IL6 TNF
20 11.99 CD19 IL10 IL6 MPO TNF
21 11.96 CXCL8 IL1B IL6 TNF
22 11.94 CD19 IL1B IL6 TNF
23 11.93 CXCL8 IL1B LBP TNF
24 11.92 CXCL8 IL1B IL6
25 11.9 CXCL8 IL1B IL6 TNF
26 11.89 ENO2 IL6 TIMP1
27
Show member pathways
11.89 MMP9 TIMP1 TNF
28
Show member pathways
11.87 CRP IL6 LBP TIMP1
29 11.87 CXCL8 IL1B IL6 LBP
30
Show member pathways
11.86 CXCL8 IL6 LBP
31 11.84 CXCL8 IL10 IL1B IL6 TNF
32 11.79 IL10 IL1B TNF
33 11.72 IL10 IL6 TNF
34 11.71 CXCL8 IL10 IL1B IL6 TNF
35 11.69 CXCL8 IL6 MMP9
36 11.68 CD19 IL10 IL1B IL6 TNF
37 11.66 CXCL8 MMP9 TIMP1
38 11.61 CXCL8 IL1B IL6 TNF
39 11.54 IL6 MMP9 MPO TNF
40 11.52 IL1B IL6 TNF
41
Show member pathways
11.52 CXCL8 IL1B IL6 MMP9 TNF
42 11.43 CXCL8 IL1B IL6 MMP9 TIMP1 TNF
43 11.39 CXCL8 IL6 MMP9
44 11.36 IL1B IL6 TNF
45 11.36 IL10 IL1B IL6 TNF
46 11.34 IL1B IL6 TNF
47 11.34 IL10 IL1B IL6 TNF
48 11.34 CXCL8 IL10 IL1B IL6 TNF
49 11.28 CXCL8 IL10 IL1B IL6 LBP MMP9
50 11.26 IL10 IL1B IL6 TNF

GO Terms for Appendicitis

Cellular components related to Appendicitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 ALB CD19 CRP DMBT1 ENO2 IL1B
2 extracellular region GO:0005576 9.73 ALB CRP CXCL8 DMBT1 IL10 IL1B
3 extracellular space GO:0005615 9.44 ALB CRP CXCL8 DMBT1 ENO2 IL10

Biological processes related to Appendicitis according to GeneCards Suite gene sharing:

(show all 41)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.97 ALB IL10 IL6 MMP9 MPO TIMP1
2 cellular protein metabolic process GO:0044267 9.94 ALB DMBT1 IL6 TIMP1
3 defense response to bacterium GO:0042742 9.92 IL10 LBP MPO TNF
4 aging GO:0007568 9.89 IL10 IL6 MPO TIMP1
5 inflammatory response GO:0006954 9.88 CRP CXCL8 IL10 IL1B IL6 TNF
6 response to organic substance GO:0010033 9.84 IL10 TIMP1 TNF
7 defense response to Gram-negative bacterium GO:0050829 9.84 DMBT1 IL6 LBP
8 response to lipopolysaccharide GO:0032496 9.83 IL10 IL1B IL6 LBP MPO
9 response to glucocorticoid GO:0051384 9.82 IL10 IL6 TNF
10 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.81 IL10 IL1B IL6 TNF
11 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 IL1B IL6 TNF
12 acute-phase response GO:0006953 9.72 CRP IL6 LBP
13 lipopolysaccharide-mediated signaling pathway GO:0031663 9.71 IL1B LBP TNF
14 positive regulation of interleukin-8 production GO:0032757 9.7 IL1B LBP TNF
15 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
16 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.68 IL1B TNF
17 positive regulation of macrophage activation GO:0043032 9.68 IL10 LBP
18 cellular response to hepatocyte growth factor stimulus GO:0035729 9.68 IL10 IL6
19 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.67 IL1B TNF
20 response to molecule of bacterial origin GO:0002237 9.67 CXCL8 IL10
21 positive regulation of chemokine biosynthetic process GO:0045080 9.66 IL1B TNF
22 opsonization GO:0008228 9.65 CRP LBP
23 endothelial cell apoptotic process GO:0072577 9.65 IL10 TNF
24 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.65 IL10 MMP9 TNF
25 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.63 IL10 TIMP1
26 regulation of establishment of endothelial barrier GO:1903140 9.63 IL1B TNF
27 positive regulation of chemokine production GO:0032722 9.63 IL6 LBP TNF
28 response to yeast GO:0001878 9.62 IL6 MPO
29 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
30 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.61 IL6 TNF
31 positive regulation of fever generation GO:0031622 9.6 IL1B TNF
32 sequestering of triglyceride GO:0030730 9.58 IL1B TNF
33 receptor biosynthetic process GO:0032800 9.57 IL10 TNF
34 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.56 IL1B TNF
35 positive regulation of interleukin-6 production GO:0032755 9.56 IL1B IL6 LBP TNF
36 cellular response to lipopolysaccharide GO:0071222 9.55 CXCL8 IL10 IL6 LBP TNF
37 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.54 IL10 IL1B TNF
38 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
39 defense response to Gram-positive bacterium GO:0050830 9.35 CRP DMBT1 IL6 LBP TNF
40 negative regulation of growth of symbiont in host GO:0044130 8.92 IL10 LBP MPO TNF
41 immune response GO:0006955 10.04 CXCL8 IL10 IL1B IL6 TNF

Molecular functions related to Appendicitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 CXCL8 IL10 IL1B IL6 TIMP1 TNF

Sources for Appendicitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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