Apraxia malady

NINDS: Apraxia (called "dyspraxia" if mild) is a neurological disorder characterized by loss of the ability to execute or carry out skilled movements and gestures, despite having the desire and the physical ability to perform them. Apraxia results from dysfunction of the cerebral hemispheres of the brain, especially the parietal lobe, and can arise from many diseases or damage to the brain.There are several kinds of apraxia, which may occur alone or together. The most common is buccofacial or orofacial apraxia, which causes the inability to carry out facial movements on command such as licking lips, whistling, coughing, or winking. Other types of apraxia include limb-kinetic apraxia (the inability to make fine, precise movements with an arm or leg), ideomotor apraxia (the inability to make the proper movement in response to a verbal command), ideational apraxia (the inability to coordinate activities with multiple, sequential movements, such as dressing, eating, and bathing), verbal apraxia (difficulty coordinating mouth and speech movements), constructional apraxia (the inability to copy, draw, or construct simple figures), and oculomotor apraxia (difficulty moving the eyes on command). Apraxia may be accompanied by a language disorder called aphasia. Corticobasal ganglionic degeneration is a disease that causes a variety of types of apraxia, especially in elderly adults.³¹

MalaCards: Apraxia, also known as dyspraxia, is related to early-onset ataxia with oculomotor apraxia and hypoalbuminemia and oculomotor apraxia. An important gene associated with Apraxia is APTX (aprataxin), and among its related pathways are DNA damage_NHEJ mechanisms of DSBs repair and DNA Damage. The compounds pemoline and spec-t have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and parietal lobe, and related mouse phenotypes are cellular and nervous system.

Disease Ontology: An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities.⁶

Wikipedia: Apraxia (from the Greek root word praxis, for an act, work, or deed, preceded by an privative a, meaning...⁴⁴ more...

Aliases & Descriptions:

apraxia 6 30 31 8 dyspraxia 30 31 apraxias 32 43 apraxia (context-dependent category) 6

dyspraxia (finding) 6 dyspraxia syndrome 6 apraxia (finding) 6 verbal apraxia 30

Diseases related to apraxia by text searches and GeneDecks gene sharing:

(show top 50)    (show all 107)

id	Related Disease	Score	Top Affiliating Genes
1	early-onset ataxia with oculomotor apraxia and hypoalbuminemia	34.2	APTX, HTT, SLC6A3
2	oculomotor apraxia	32.7	KIF7, PC, SETX, PARP1, XRCC1, XRCC4
3	ideomotor apraxia	32.7	NAGLU, IKBKAP
4	spinocerebellar ataxia autosomal recessive 1	32.5	SETX, AFP
5	ataxia-ocular apraxia	32.2	SETX, FHIT, APTX, PNKP, AFP
6	gait apraxia	31.4	CDR2, SLC25A20
7	ataxia telangiectasia	29.6	SETX, PARP1, XRCC1, ATM, MRE11A, APTX
8	ataxia	28.1	KIF7, SETX, LIG3, PARP1, XRCC1, XRCC4
9	aphasia	27.3	BRAP, GRN, MAPT, CBS, COPS2
10	nephronophthisis	26.8	CEP290, ARL13B, INPP5E, CC2D2A, TMEM216, TMEM67
11	cerebellar ataxia	26.5	KIF7, SETX, SACS, ATCAY, ATM, FXN
12	myoclonic cerebellar dyssynergia	13.7	SETX, APTX
13	coach syndrome	13.7	CC2D2A, TMEM67, RPGRIP1L
14	congenital hepatic fibrosis	13.6	CC2D2A, TMEM67, RPGRIP1L
15	multicystic renal dysplasia, bilateral	13.6	CEP290, TMEM216, TMEM67
16	ataxia with isolated vitamin e deficiency	13.6	SETX, FXN, APTX, TTPA
17	cep290-related bardet-biedl syndrome	13.5	CEP290, TMEM67
18	coloboma	13.5	CEP290, CC2D2A, TMEM67, RPGRIP1L, NPHP1
19	nephronophthisis 4	13.4	NPHP1, NPHP4
20	familial juvenile hyperuricemic nephropathy	13.4	OFD1, NPHP1, NPHP4
21	parkinsonian disorders	13.4	MAPT, SLC6A3
22	joubert syndrome and related disorders	13.4	CEP290, CC2D2A, TMEM67, RPGRIP1L, AHI1, NPHP1
23	bladder cancer susceptibility	13.4	PARP1, XRCC1, XRCC4
24	pigmentary retinopathy	13.4	KIF7, CEP290, TMEM67, TTC21B
25	memory impairment	13.4	GRN, MAPT, PSEN1, SLC6A3
26	nephronopthisis	13.3	NPHP1, NPHP3, NPHP4
27	cystic kidney	13.3	NPHP1, NPHP3, NPHP4
28	primary progressive aphasia	13.3	GRN, MAPT
29	nephronophthisis 1	13.3	AHI1, NPHP1, NPHP3, NPHP4
30	acute lymphoblastic leukemia, childhood	13.3	PARP1, XRCC1, ATM, FHIT
31	fundus dystrophy	13.3	CEP290, ARL13B, INPP5E, CC2D2A, TMEM67, RPGRIP1L
32	encephalocele	13.3	CEP290, CC2D2A, TMEM216, TMEM67, RPGRIP1L, TCTN2
33	encephaloceles	13.3	CEP290, CC2D2A, TMEM216, TMEM67, RPGRIP1L, TCTN2
34	meckel syndrome	13.3	CEP290, CC2D2A, TMEM216, TMEM67, RPGRIP1L, TCTN2
35	tremor	13.2	SETX, ATCAY, RPGRIP1L, POLG, SLC6A3
36	olivopontocerebellar atrophy	13.2	FXN, MAPT, HTT, TTPA, POLG
37	dyslexia	13.2	ZNF280D, PARP1, FOXP2, SLC6A3
38	xeroderma pigmentosum	13.2	PARP1, XRCC1, XRCC4, ATM, MRE11A
39	language disorder	13.2	FOXP2, MECP2
40	xeroderma pigmentosum, group d	13.2	XRCC1, XRCC4
41	leber congenital amaurosis	13.1	CEP290, TMEM67, RPGRIP1L, NPHP3, NPHP4
42	multiple system atrophy	13.1	APTX, MAPT, IKBKAP, HTT, SLC6A3
43	lewy body dementia	13.1	GRN, MAPT, IKBKAP, SLC6A3
44	albinism	13.0	XRCC1, XRCC4, ATCAY, HTT, CBS, TTPA
45	bardet-biedl syndrome	13.0	KIF7, CEP290, ARL13B, INPP5E, TMEM67, RPGRIP1L
46	protein s deficiency	13.0	CEP290, FXN, INPP5E, TTPA, SLC25A20
47	retinal degeneration	13.0	CEP290, TMEM67, RPGRIP1L, TTC21B, NPHP1, NPHP3
48	tauopathy	12.9	NAGLU, GRN, MAPT, HTT, PSEN1
49	stickler syndrome	12.9	PARP1, CEP290, CBS, NPHP1, NPHP4
50	aicardi-goutieres syndrome	12.9	PC, MECP2, MAPT, PSEN1, POLG

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to apraxia:

²²

MGI Mouse Phenotypes related to apraxia:

²⁵ (show all 18)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cellular phenotype	MP:0005384	INF	CC2D2A, HTT, CBS, TMEM67, OFD1, COPS2
2	nervous system phenotype	MP:0003631	INF	KIF7, INPP5E, ARL13B, FOXP2, FXN, MRE11A
3	mortality/aging	MP:0010768	INF	RPGRIP1L, OFD1, TMEM67, CBS, HTT,
4	embryogenesis phenotype	MP:0005380	INF	NPHP3, CC2D2A, MECP2, ARL13B, FOXP2, FXN
5	craniofacial phenotype	MP:0005382	INF	OFD1, RPGRIP1L, TTC21B, TCTN2, PSEN1, NPHP3
6	vision/eye phenotype	MP:0005391	INF	RPGRIP1L, AHI1, TTPA, TCTN2, PSEN1, NPHP1
7	behavior/neurological phenotype	MP:0005386	INF	HTT, CBS, AHI1, TTPA, PSEN1, NPHP3
8	integument phenotype	MP:0010771	INF	HTT, CBS, PSEN1, POLG, SLC6A3,
9	endocrine/exocrine gland phenotype	MP:0005379	9.2	PSEN1, HTT, MECP2, ATCAY, XRCC4, AFP
10	no phenotypic analysis	MP:0003012	8.1	GRN, MAPT, HTT, POLG, NPHP1, MECP2
11	reproductive system phenotype	MP:0005389	7.0	CBS, TTPA, POLG, NPHP1, NPHP4, SLC6A3
12	renal/urinary system phenotype	MP:0005367	INF	NPHP4, NPHP3, NPHP1, PSEN1, AHI1, RPGRIP1L
13	cardiovascular system phenotype	MP:0005385	INF	RPGRIP1L, TTPA, TCTN2, PSEN1, POLG, NPHP3
14	growth/size phenotype	MP:0005378	INF	RPGRIP1L, OFD1, TMEM67, CBS, HTT, AHI1
15	skeleton phenotype	MP:0005390	INF	TTC21B, PSEN1, POLG, NPHP3, SLC6A3, RPGRIP1L
16	limbs/digits/tail phenotype	MP:0005371	INF	PSEN1, TCTN2, TCTN1, TTC21B, RPGRIP1L, OFD1
17	muscle phenotype	MP:0005369	INF	, SLC6A3, POLG, PSEN1, TTPA, CBS
18	homeostasis/metabolism phenotype	MP:0005376	INF	APTX, , HTT, CBS, AHI1, TTPA

Articles related to apraxia:

(show all 49)

id	Title	Authors	Year	Affiliating Genes
1	A missense mutation in PIK3R5 gene in a family with ataxia and oculomotor apraxia. (22065524)	Tassan N.A.... Bohlega S.	2012	PIK3R5
2	Ataxia with oculomotor apraxia type1 (AOA1): novel an d recurrent aprataxin mutations, coenzyme Q10 analyses, and clinical findings i n Italian patients. (21465257)	Castellotti B.... Gellera C.	2011	APTX
3	Clinical and molecular characterization of ataxia wit h oculomotor apraxia patients in Saudi Arabia. (21324166)	Bohlega S.A.... Al Tassan N.A.	2011	MRE11A, SETX
4	Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminaemia. (21486904)	Yokoseki A.... Onodera O.	2011	APTX
5	Aberrant splicing of the senataxin gene in a patient with ataxia with oculomotor apraxia type 2. (19727998)	Fogel B.L.... Perlman S.	2009	SETX
6	Short-patch single-strand break repair in ataxia oculomotor apraxia-1. (19442253)	Reynolds J.J.... Caldecott K.W.	2009	APTX
7	Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. (19103743)	Reynolds J.J.... Caldecott K.W.	2009	APTX
8	Ataxia with oculomotor apraxia type 2: a clinical and genetic study of 19 patients. (19141356)	Tazir M.... Koenig M.	2009	SETX
9	A novel nonsense mutation in a Japanese family with a taxia with oculomotor apraxia type 2 (AOA2). (19893583)	Nakamura K.... Ikeda S.	2009	SETX
10	Exon deletions and intragenic insertions are not rare in ataxia with oculomotor apraxia 2. (19744353)	Bernard V.... ZA1hlke C.	2009	SETX
11	Functional role for senataxin, defective in ataxia oc ulomotor apraxia type 2, in transcriptional regulation. (19515850)	Suraweera A.... Lavin M.F.	2009	SETX
12	Ataxia with oculomotor apraxia type 1 (AOA1): clinical and neuropsychological features in 2 new patients and differential diagnosis. (18403580)	D'Arrigo S.... Pantaleoni C.	2008	APTX
13	Ataxia with oculomotor apraxia type 2: novel mutation s in six patients with juvenile age of onset and elevated serum alpha-fetoprote in. (19569000)	Bernard V.... ZA1hlke C.	2008	SETX
14	Nigrostriatal involvement in ataxia with oculomotor apraxia type 1. (18004640)	Salvatore E.... Filla A.	2008	SLC6A3
15	Complete deletion of the aprataxin gene: ataxia with oculomotor apraxia type 1 with severe phenotype and cognitive deficit. (18202221)	Yoon G.... Banwell B.	2008	APTX
16	Apraxia of lid opening mimicking ptosis in compound heterozygosity for A467T and W748S POLG1 mutations. (18546343)	Paus S.... Kornblum C.	2008	POLG
17	Identification and characterisation of a large Senataxin (SETX) gene duplication in ataxia with ocular apraxia type 2 (AOA2). (18663494)	Arning L.... Timmann D.	2008	SETX
18	Apraxia of speech and nonfluent aphasia: a new clinical marker for corticobasal degeneration and progressive supranuclear palsy. (18989114)	Josephs K.A.... Duffy J.R.	2008	MAPT
19	'Pseudodominant inheritance' of ataxia with ocular apraxia type 2 (AOA2). (18350359)	Schols L.... Timmann D.	2008	SETX
20	A novel form of ataxia oculomotor apraxia characterized by oxidative stress and apoptosis resistance. (17347666)	Gueven N.... Lavin M.F.	2007	PARP1
21	A novel mutation of aprataxin associated with ataxia ocular apraxia type 1: phenotypical and genotypical characterization. (17572444)	Ferrarini M.... Fabrizi G.M.	2007	APTX
22	Ovarian failure in ataxia with oculomotor apraxia type 2. (17593543)	Lynch D.R.... Nagan N.	2007	SETX
23	Senataxin, defective in ataxia oculomotor apraxia type 2, is involved in the defense against oxidative DNA damage. (17562789)	Suraweera A.... Lavin M.F.	2007	SETX
24	Muscle coenzyme Q10 deficiencies in ataxia with oculomotor apraxia 1. (17242337)	Le Ber I.... Durr A.	2007	APTX
25	Ataxia-oculomotor apraxia 2 patients show no increased sensitivity to ionizing radiation. (17720498)	Nahas S.A.... Brais B.	2007	SETX
26	Atypical presentation of ataxia-oculomotor apraxia type 1. (16700949)	Shahwan A.... King M.D.	2006	APTX
27	Autosomal recessive cerebellar ataxias with oculomotor apraxia (16518257)	Le Ber I.... Durr A.	2006	APTX, SETX
28	Ataxia with oculomotor apraxia type 2: a clinical, pathologic, and genetic study. (16636238)	Criscuolo C.... Casali C.	2006	AFP, SETX
29	New autosomal recessive cerebellar ataxias with oculomotor apraxia. (16131425)	Le Ber I.... Durr A.	2005	APTX, SETX
30	Familial cognitive impairment with ataxia with oculomotor apraxia. (15996403)	Mahajnah M.... Straussberg R.	2005	APTX
31	Very late onset in ataxia oculomotor apraxia type I. (15852392)	Criscuolo C.... Filla A.	2005	APTX
32	Novel splice variants increase molecular diversity of aprataxin, the gene responsible for early-onset ataxia with ocular motor apraxia and hypoalbuminemia. (15276230)	Hirano M.... Ueno S.	2004	APTX
33	Senataxin, the ortholog of a yeast RNA helicase, is mutant in ataxia- ocular apraxia 2. (14770181)	Moreira M.-C.... Koenig M.	2004	AFP, SETX
34	The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4. (15380105)	Clements P.M.... Caldecott K.W.	2004	XRCC4, XRCC1, APTX
35	Ataxia with oculomotor apraxia type 1 in Southern Italy: late onset and variable phenotype. (15596775)	Criscuolo C.... Filla A.	2004	APTX
36	Cerebellar ataxia with oculomotor apRAxia type 1: clinical and genetic studies. (14506070)	Le Ber I.... Duerr A.	2003	APTX, HTT
37	Early-onset ataxia with ocular motor apraxia and hypoalbuminemia: the aprataxin gene mutations. (12196655)	Shimazaki H.... Nishizawa M.	2002	APTX
38	Homozygosity mapping of Portuguese and Japanese forms of ataxia-oculomotor apraxia to 9p13, and evidence for genetic heterogeneity. (11170899)	Moreira M.C.... Koenig M.	2001	APTX
39	Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. (11586299)	Date H.... Tsuji S.	2001	APTX
40	The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn- finger protein aprataxin. (11586300)	Moreira M.-C.... Koenig M.	2001	FHIT, APTX, PNKP
41	Autosomal recessive cerebellar ataxia with oculomotor apraxia (ataxia-telangiectasia-like syndrome) is linked to chromosome 9q34. (11022012)	NAcmeth A.H.... Taylor A.M.	2000	SETX
42	Children with ocular motor apraxia type Cogan carry deletions in the gene (NPHP1) for juvenile nephronophthisis. (10839884)	Betz R.... Hildebrandt F.	2000	NPHP1
43	Congenital oculomotor apraxia and partial deficiency of pyruvate carboxylase (9575131)	Vaquerizo Madrid J.... Remon Alvarez-Arenas J.	1997	PC
44	Constructional apraxia in Alzheimer's disease correlates with neuritic neuropathology in occipital cortex. (9001734)	Nielson K.A.... Cotman C.W.	1996	MAPT
45	Ataxia-oculomotor apraxia syndrome. (7782601)	Gascon G.G.... Hannan M.A.	1995	APTX
46	Ataxia-ocular motor apraxia syndrome: an investigation of cellular radiosensitivity of patients and their families. (7891378)	Hannan M.A.... Gascon G.G.	1994	APTX
47	Ataxia with Oculomotor Apraxia Typ e 1 (20301629)	Coutinho P.... Barbot C.	1993	APTX
48	Ataxia with Oculomotor Apraxia Ty pe 2 (20301333)	Moreira M.C.... Koenig M.	1993	SETX
49	Ataxia-ocular motor apraxia: a syndrome mimicking ataxia-telangiectasia. (3239952)	Aicardi J.... Moe P.	1988	APTX

Genes related to apraxia according to GeneCards:

(show all 50)

id	Symbol	Description	Score	GeneCards Section Context
1	APTX	aprataxin	11.1	Summaries, Publications, Orthologs
2	SETX	senataxin	11.1	Summaries, Publications, Orthologs
3	NPHP1	nephronophthisis 1 (juvenile)	11.1	Summaries, Publications
4	COMA	Cogan-type congential oculomotor apraxia	11.1	Aliases & Descriptions
5	AFP	alpha-fetoprotein	11.0	Publications
6	HTT	huntingtin	11.0	Publications
7	SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	11.0	Publications
8	TMEM216	transmembrane protein 216	11.0
9	TCTN1	tectonic family member 1	11.0
10	INPP5E	inositol polyphosphate-5-phosphatase, 72 kDa	11.0
11	OFD1	oral-facial-digital syndrome 1	11.0
12	TCTN2	tectonic family member 2	11.0
13	KIF7	kinesin family member 7	11.0
14	ARL13B	ADP-ribosylation factor-like 13B	11.0
15	TTC21B	tetratricopeptide repeat domain 21B	11.0
16	TMEM67	transmembrane protein 67	11.0
17	CEP290	centrosomal protein 290kDa	11.0
18	RPGRIP1L	RPGRIP1-like	11.0
19	CC2D2A	coiled-coil and C2 domain containing 2A	11.0
20	XRCC1	X-ray repair complementing defective repair in Chinese hamster cells 1	11.0	Publications
21	AHI1	Abelson helper integration site 1	11.0
22	XRCC4	X-ray repair complementing defective repair in Chinese hamster cells 4	11.0	Publications
23	PARP1	poly (ADP-ribose) polymerase 1	11.0	Publications
24	PSEN1	presenilin 1	11.0
25	PNKP	polynucleotide kinase 3'-phosphatase	11.0	Publications
26	TTPA	tocopherol (alpha) transfer protein	11.0
27	PC	pyruvate carboxylase	11.0	Publications
28	FXN	frataxin	11.0
29	MRE11A	MRE11 meiotic recombination 11 homolog A (S. cerevisiae)	11.0	Publications
30	MAPT	microtubule-associated protein tau	11.0	Publications
31	ATM	ataxia telangiectasia mutated	11.0
32	FOXP2	forkhead box P2	11.0
33	FHIT	fragile histidine triad	11.0	Publications
34	MORF4	mortality factor 4	11.0
35	NPHP3	nephronophthisis 3 (adolescent)	11.0
36	ATCAY	ataxia, cerebellar, Cayman type	11.0
37	BRAP	BRCA1 associated protein	11.0
38	COPS2	COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)	11.0
39	PIK3R5	phosphoinositide-3-kinase, regulatory subunit 5	11.0	Publications
40	LIG3	ligase III, DNA, ATP-dependent	11.0
41	GRN	granulin	11.0
42	ZNF280D	zinc finger protein 280D	11.0	Disorders
43	POLG	polymerase (DNA directed), gamma	11.0	Publications
44	DDX19B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B	11.0	Disorders
45	CBS	cystathionine-beta-synthase	11.0
46	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	11.0
47	NPHP4	nephronophthisis 4	11.0
48	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0
49	TMEM138	transmembrane protein 138	10.0	Disorders
50	C5orf42	chromosome 5 open reading frame 42	-9.4	Disorders

Pathways related to apraxia according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	DNA damage_NHEJ mechanisms of DSBs repair41	9.9	PNKP, MRE11A, XRCC4
2	DNA Damage3	9.8	XRCC1, ATM, MRE11A, PNKP
3	DNA damage NHEJ mechanisms of DSBs repair10	9.7	PNKP, MRE11A, XRCC4
4	DNA Repair Mechanisms36	9.1	LIG3, POLG, PNKP, MRE11A, ATM, XRCC4

Compounds related to apraxia according to GeneDecks:

(show all 20)

id	Compound	Score	Top Affiliating Genes
1	pemoline32	10.5	NPHP1, SLC6A3
2	spec-t32	10.2	AFP, SLC6A3, PSEN1, MAPT
3	alpha tocopherol32	10.1	TTPA, APTX, FXN, XRCC1, SETX
4	methylmethanesulfonate32	10.1	LIG3, PARP1, XRCC1, APTX
5	polynucleotide32	10.0	LIG3, XRCC1, XRCC4, APTX, PNKP
6	bleomycin32 9 9	11.9	AFP, PSEN1, ATM, XRCC1, LIG3
7	vitamin b1232	9.7	MAPT, CBS, PSEN1, AFP
8	camptothecin32 42 9 9	12.7	MRE11A, ATM, XRCC1, PARP1, LIG3
9	folate32	9.2	AFP, PSEN1, CBS, MAPT, MECP2, XRCC1
10	glutamine32	9.1	TTPA, PSEN1, POLG, AFP, HTT, MAPT
11	methionine32	8.7	PSEN1, CBS, MAPT, MECP2, FHIT, XRCC1
12	arginine32	INF	, SLC6A3, PSEN1, TTPA, CBS, MAPT
13	zinc32 18	INF	AFP, CBS, MAPT, APTX, MECP2, FXN
14	valproate32	INF	SLC6A3, POLG, MAPT, MECP2,
15	alanine32	INF	AFP, POLG, HTT, MECP2, FOXP2, XRCC4
16	lactate32	INF	AFP, POLG, HTT, MAPT, FHIT, ATM
17	n acetylcysteine32	INF	MAPT, FHIT, ATM,
18	oxygen32 18	INF	AFP, POLG, PSEN1, TTPA, PNKP, CBS
19	vitamin-e32	INF	TTPA, CBS, APTX, FXN, , SETX
20	h2o232	INF	SLC6A3, PSEN1, CBS, MAPT, XRCC1, PARP1

Cellular components related to apraxia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	cilium axoneme	GO:035085	9.8	NPHP1, TTC21B, RPGRIP1L, MAPT, INPP5E
2	TCTN-B9D complex	GO:036038	9.8	TCTN2, TCTN1, AHI1, TMEM67, TMEM216, CC2D2A
3	microtubule basal body	GO:005932	9.1	CEP290, NPHP4, TCTN2, TCTN1, AHI1, RPGRIP1L
4	cilium	GO:005929	8.4	NPHP4, NPHP3, AHI1, RPGRIP1L, OFD1, TMEM138
5	centrosome	GO:005813	INF	NPHP4, PSEN1, AHI1, RPGRIP1L, OFD1, TMEM67
6	primary cilium	GO:072372	INF	, AHI1, NPHP3

Biological processes related to apraxia according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	photoreceptor cell outer segment organization	GO:035845	10.3	AHI1, NPHP1
2	double-strand break repair	GO:006302	10.0	APTX, MRE11A, ATM, XRCC4, SETX
3	neuron apoptotic process	GO:051402	10.0	ATM, HTT, PSEN1
4	reciprocal meiotic recombination	GO:007131	9.9	MRE11A, ATM, LIG3
5	visual behavior	GO:007632	9.9	NPHP1, NPHP4
6	proprioception	GO:019230	9.8	FXN, MECP2
7	cilium morphogenesis	GO:060271	9.6	CEP290, NPHP3, TCTN2, TCTN1, AHI1, OFD1
8	DNA repair	GO:006281	9.4	PNKP, MRE11A, ATM, XRCC4, XRCC1, PARP1
9	negative regulation of neuron apoptotic process	GO:043524	9.2	PSEN1, HTT, MECP2, XRCC4
10	cell death	GO:008219	INF	, SLC6A3, POLG, APTX, SACS, SETX
11	cilium assembly	GO:042384	INF	TCTN2, AHI1, RPGRIP1L, TMEM138, TMEM67, TMEM216

Molecular functions related to apraxia according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	, MAPT, , HTT, CBS, TMEM67
2	polynucleotide 3-phosphatase activity	GO:046403	10.3	APTX, PNKP
3	protein N-terminus binding	GO:047485	9.1	SLC6A3, APTX, MECP2, ATM, PARP1