MCID: APR001
MIFTS: 53

Apraxia malady

Summaries for Apraxia

About this section
Sources:
8Disease Ontology, 43NINDS, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
NINDS:43 Apraxia (called "dyspraxia" if mild) is a neurological disorder characterized by loss of the ability to execute or carry out skilled movements and gestures, despite having the desire and the physical ability to perform them. Apraxia results from dysfunction of the cerebral hemispheres of the brain, especially the parietal lobe, and can arise from many diseases or damage to the brain.There are several kinds of apraxia, which may occur alone or together. The most common is buccofacial or orofacial apraxia, which causes the inability to carry out facial movements on command such as licking lips, whistling, coughing, or winking. Other types of apraxia include limb-kinetic apraxia (the inability to make fine, precise movements with an arm or leg), ideomotor apraxia (the inability to make the proper movement in response to a verbal command), ideational apraxia (the inability to coordinate activities with multiple, sequential movements, such as dressing, eating, and bathing), verbal apraxia (difficulty coordinating mouth and speech movements), constructional apraxia (the inability to copy, draw, or construct simple figures), and oculomotor apraxia (difficulty moving the eyes on command). Apraxia may be accompanied by a language disorder called aphasia. Corticobasal ganglionic degeneration is a disease that causes a variety of types of apraxia, especially in elderly adults.

MalaCards: Apraxia, also known as apraxias, is related to ideomotor apraxia and aphasia. An important gene associated with Apraxia is APTX (aprataxin), and among its related pathways are Wnt / Hedgehog / Notch and Neuroscience. The compounds pemoline and alpha tocopherol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and parietal lobe, and related mouse phenotypes are taste/olfaction and endocrine/exocrine gland.

Disease Ontology:8 An agnosia that is a loss of the ability to map out physical actions in order to repeat them in functional activities.

Wikipedia:63 Apraxia (from Greek praxis, an act, work, or deed) is the inability to execute learned purposeful... more...

Aliases & Classifications for Apraxia

About this section
Sources:
42NIH Rare Diseases, 8Disease Ontology, 43NINDS, 10DISEASES, 44Novoseek, 60UMLS, 25ICD10
See all sources

Related Diseases for Apraxia

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Apraxia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 145)
idRelated DiseaseScoreTop Affiliating Genes
1ideomotor apraxia31.2COPS2, CBS
2aphasia30.9MAPT, CBS
3gait apraxia30.7MECP2, CDKL5, CDR2, SLC25A20
4alzheimer's disease30.5HTT, PSEN1, MAPT, CBS, TTPA, SLC6A3
5progressive supranuclear palsy30.5SLC6A3, MAPT
6parkinson's disease30.5MAPT, SLC6A3
7cerebellar ataxia30.4APTX, ATM, TTPA, FXN, SETX
8dementia30.4HTT, PSEN1, MAPT, CBS, SLC6A3
9spinocerebellar ataxia autosomal recessive 130.4MORF4
10huntington's disease30.2HTT
11ataxia telangiectasia30.2APTX, ATM, AFP, SETX
12hydrocephalus30.2MAPT, AFP
13multiple system atrophy30.1SLC6A3, MAPT, HTT
14motor neuron disease29.9MAPT, HTT
15brain disease29.9CDKL5, MAPT, MECP2, PSEN1
16pick's disease29.9MAPT, PSEN1, HTT
17amyotrophic lateral sclerosis29.9HTT, PSEN1, MAPT, SLC6A3, SETX
18myopathy29.8FXN
19ataxia with vitamin e deficiency29.7SETX, FXN, TTPA, APTX
20frontotemporal dementia29.7MAPT, PSEN1
21intellectual disability29.7CDKL5, CBS, MECP2
22movement disease29.7SLC6A3, MAPT, HTT
23spinocerebellar ataxia29.7HTT, MAPT, TTPA, FXN
24neuropathy29.7SETX
25down syndrome29.7PSEN1, MECP2, AFP, MAPT, CBS
26pervasive developmental disorder29.7MECP2, FOXP2
27vascular dementia29.7MAPT, PSEN1
28cerebrovascular disease29.7CBS, SLC6A3
29early-onset ataxia with oculomotor apraxia and hypoalbuminemia10.6
30ataxia with oculomotor apraxia type 210.5
31ataxia with oculomotor apraxia type 110.4
32agnosia10.4
33blepharospasm10.3
34developmental dyspraxia10.3
35cerebritis10.3
36speech disorder10.3
37oculomotor apraxia cogan type10.3
38ocular motor apraxia, cogan type10.3
39developmental coordination disorder10.3
40rolandic epilepsy, mental retardation, and speech dyspraxia, x-linked10.2
41neuronitis10.2
42childhood apraxia of speech10.2
43rolandic epilepsy, mental retardation, and speech dyspraxia10.2
44eyelid disease10.1
45anterior cerebral artery infarction10.1
46mutism10.1
47galactosemia10.1
48peripheral neuropathy10.0APTX
49doid:401910.0APTX, NPHP1, TTPA, SETX
50speech and communication disorders10.0FOXP2, MECP2

Graphical network of the top 20 diseases related to Apraxia:



Diseases related to apraxia

Clinical Features for Apraxia

About this section

Drugs & Therapeutics for Apraxia

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Apraxia

Drug clinical trials:

Search ClinicalTrials for Apraxia

Search NIH Clinical Center for Apraxia

Search CenterWatch for Apraxia

Genetic Tests for Apraxia

About this section

Anatomical Context for Apraxia

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Apraxia:

32
Brain, Testes, Parietal lobe, Eye, Cortex, Subthalamic nucleus, Spinal cord, Occipital lobe

Animal Models for Apraxia or affiliated genes

About this section
Sources:
36MGI
See all sources

Publications for Apraxia

About this section
Sources:
50PubMed
See all sources

Articles related to Apraxia:

(show top 50)    (show all 586)
idTitleAuthorsYear
1
Callosal disconnection and limb-kinetic apraxia. (23972140)
2013
2
Progression of logopenic variant primary progressive aphasia to apraxia and semantic memory deficits. (24176108)
2013
3
Early development in infants at risk of childhood apraxia of speech: a longitudinal investigation. (23573797)
2013
4
Response interference between functional and structural object-related actions is increased in patients with ideomotor apraxia. (22515637)
2013
5
Apraxia in left-handers. (23864275)
2013
6
Cortical Thickness in Children Receiving Intensive Therapy for Idiopathic Apraxia of Speech. (23974724)
2013
7
Limb apraxia in multiple sclerosis: prevalence and impact on manual dexterity and activities of daily living. (22464095)
2012
8
Constrained versus unconstrained intensive language therapy in two individuals with chronic, moderate-to-severe aphasia and apraxia of speech: behavioral and fMRI outcomes. (22294409)
2012
9
Error reduction therapy in reducing struggle and grope behaviours in apraxia of speech. (22250885)
2012
10
Isolated gait apraxia from an acute unilateral parasagittal lesion. (21880413)
2011
11
Apraxia in neurorehabilitation: Classification, assessment and treatment. (21447909)
2011
12
A model-based approach to long-term recovery of limb apraxia after stroke. (22082079)
2011
13
Can subcortical infarction cause apraxia of eyelid opening? (21778059)
2011
14
Sensory neuronopathy in ataxia with oculomotor apraxia type 2. (20869730)
2010
15
Dissociation apraxia secondary to right premotor stroke. (19695272)
2010
16
Childhood apraxia of speech and multiple phonological disorders in Cairo-Egyptian Arabic speaking children: language, speech, and oro-motor differences. (20202694)
2010
17
Apraxia related with subcortical lesions due to cerebrovascular disease. (20028344)
2010
18
Ataxia oculomotor apraxia type 2: course over 27 years and a novel stop mutation in the senataxin gene. (19377860)
2009
19
A model-based approach to understanding apraxia in Corticobasal Syndrome. (19082735)
2009
20
Gait apraxia in multiple sclerosis. (19831123)
2009
21
Using telerehabilitation to assess apraxia of speech in adults. (18821157)
2009
22
Improvements in limb kinetic apraxia by repetition of a newly designed facilitation exercise in a patient with corticobasal degeneration. (19238090)
2009
23
The relationship between working memory and apraxia of speech. (19838515)
2009
24
Cognitive mechanisms of visuomotor transformation in movement imitation: examining predictions based on models of apraxia and motor control. (19473740)
2009
25
Apraxia of lid opening mimicking ptosis in compound heterozygosity for A467T and W748S POLG1 mutations. (18546343)
2008
26
Poor dopaminergic response of impaired dexterity in Parkinson's disease: Bradykinesia or limb kinetic apraxia? (18649388)
2008
27
Cortico-cortical networks in patients with ideomotor apraxia as revealed by EEG coherence analysis. (18249498)
2008
28
Neural underpinnings of gesture discrimination in patients with limb apraxia. (18354006)
2008
29
Ideomotor apraxia and functional ability. (17533759)
2007
30
The prevalence of apraxia characteristics in patients with velocardiofacial syndrome as compared with other cleft populations. (17328642)
2007
31
Consonant and syllable structure patterns in childhood apraxia of speech: developmental change in three children. (16469328)
2006
32
Ataxia with oculomotor apraxia type 2: a clinical, pathologic, and genetic study. (16636238)
2006
33
Limb apraxia and cognitive impairment in progressive supranuclear palsy. (16093226)
2005
34
Clinical analysis of blepharospasm and apraxia of eyelid opening in patients with parkinsonism. (20396463)
2005
35
Assessment of apraxia: inter-rater reliability of a new apraxia test, association between apraxia and other cognitive deficits and prevalence of apraxia in a rehabilitation setting. (15573839)
2004
36
Walking difficulties in patients with Alzheimer's disease might originate from gait apraxia. (14742586)
2004
37
Impaired volitional closure of the left eyelid after right anterior cerebral artery infarction: apraxia due to interhemispheric disconnection? (14967778)
2004
38
A diagnostic marker for childhood apraxia of speech: the coefficient of variation ratio. (14608800)
2003
39
Slowly progressive pure dysgraphia with late apraxia of speech: a further variant of the focal cerebral degeneration. (14642538)
2003
40
Right orbitofrontal tumor with pedophilia symptom and constructional apraxia sign. (12633158)
2003
41
Botulinum toxin improves lid opening delays in blepharospasm-associated apraxia of lid opening. (12084888)
2002
42
Screening for apraxia: a short assessment for stroke patients. (12030446)
2002
43
Manual asymmetries in tool-use: implications for apraxia. (15513193)
2002
44
Ocular apraxia in recessive ataxia. (12020276)
2002
45
The mechanisms for adult-onset apraxia and developmental dyspraxia: an examination and comparison of error patterns. (9127059)
1997
46
Mutism, oropharyngeal apraxia and dysarthria after posterior fossa tumour excision. (9337934)
1997
47
Ataxia with Oculomotor Apraxia Type 2 (20301333)
1993
48
Are specific reading and writing difficulties causally connected with developmental spatial inability? Evidence from two cases of developmental agnosia and apraxia. (1620326)
1992
49
Ideomotor apraxia: a study of initial severity. (3673500)
1987
50
Gait apraxia in communicating hydrocephalus. (7241157)
1981

Genetic Variations for Apraxia

About this section

Expression for genes affiliated with Apraxia

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Apraxia

Search GEO for disease gene expression data for Apraxia.

Pathways for genes affiliated with Apraxia

About this section
Sources:
4Cell Signaling Technology
See all sources

Pathways related to Apraxia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3AFP, PSEN1, FOXP2
210.2MAPT, MECP2, PSEN1, HTT

Compounds for genes affiliated with Apraxia

About this section
Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Apraxia according to GeneCards/GeneDecks:

(show all 31)
idCompoundScoreTop Affiliating Genes
1pemoline4410.7NPHP1, SLC6A3
2alpha tocopherol4410.6SETX, FXN, TTPA, APTX
3coq104410.6APTX, HTT
4spec-t4410.6PSEN1, AFP, MAPT, SLC6A3
5vitamin-e4410.6SETX, FXN, TTPA, CBS, APTX
6vitamin b124410.6PSEN1, AFP, MAPT, CBS
7bleomycin44 1111.5AFP, ATM
8valproate4410.5SLC6A3, MAPT, MECP2
9folate4410.5PSEN1, MECP2, AFP, MAPT, CBS
10valine4410.5PSEN1, AFP, MAPT, SLC6A3
11nmda44 2811.4SLC6A3, CBS, MAPT, PSEN1, HTT
12glycogen44 2411.4HTT, FOXP2, PSEN1, AFP, MAPT
13methionine4410.4PSEN1, MECP2, MAPT, CBS
14iron44 2411.4HTT, ATM, AFP, CBS, FXN
15kainate44 2811.4MAPT, PSEN1, HTT
16creatinine4410.4HTT, AFP, MAPT, SLC25A20, SLC6A3
17arginine4410.4PSEN1, MECP2, MAPT, CBS, TTPA, SLC25A20
18glutamine4410.4HTT, FOXP2, PSEN1, ATM, AFP, MAPT
19zinc44 2411.3APTX, MECP2, ATM, AFP, MAPT, CBS
20glucose4410.3HTT, PSEN1, AFP, MAPT, CBS, FXN
21alanine4410.3HTT, FOXP2, PSEN1, MECP2, AFP, MAPT
22oxygen44 2411.3HTT, FOXP2, PSEN1, ATM, AFP, CBS
23s-adenosylmethionine44 11 2412.3SLC25A20, CBS, PSEN1
24h2o24410.3PSEN1, AFP, MAPT, CBS, SLC6A3
25glutamate4410.3HTT, FOXP2, PSEN1, MECP2, AFP, MAPT
26lipid4410.3HTT, PSEN1, ATM, AFP, CBS, TTPA
27cysteine4410.2HTT, PSEN1, MAPT, CBS, FXN, SLC6A3
28cholesterol44 28 11 2413.2HTT, PSEN1, AFP, CBS, TTPA
29oligonucleotide4410.0HTT, PSEN1, MECP2, AFP, CBS
30cystathionine4410.0CBS, HTT
31serine4410.0HTT, PSEN1, ATM, AFP, MAPT, CBS

GO Terms for genes affiliated with Apraxia

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Apraxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axonGO:03042410.2SLC6A3, MAPT, PSEN1, HTT

Biological processes related to Apraxia according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1proprioceptionGO:01923010.5FXN, MECP2
2positive regulation of axon extensionGO:04577310.5FXN, CDKL5, MAPT
3neuron apoptotic processGO:05140210.4HTT, PSEN1, ATM
4double-strand break repairGO:00630210.4SETX, ATM, APTX
5post-embryonic developmentGO:00979110.3FOXP2, PSEN1, MECP2
6axon cargo transportGO:00808810.3MAPT, HTT
7neuron migrationGO:00176410.3CDKL5, MAPT, PSEN1
8response to iron ionGO:01003910.2SLC6A3, FXN
9negative regulation of neuron apoptotic processGO:04352410.0HTT, PSEN1, MECP2

Molecular functions related to Apraxia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein N-terminus bindingGO:0474859.9SLC6A3, ATM, MECP2, APTX
2protein bindingGO:0055159.6HTT, APTX, NPHP1, PSEN1, MECP2, ATM

Products for genes affiliated with Apraxia

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Apraxia

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet