MCID: AQG003
MIFTS: 12

Aquagenic Syringeal Acrokeratoderm

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Aquagenic Syringeal Acrokeratoderm

MalaCards integrated aliases for Aquagenic Syringeal Acrokeratoderm:

Name: Aquagenic Syringeal Acrokeratoderm 49
Transient Reactive Papulotranslucent Acrokeratoderma 49 55
Aquagenic Palmoplantar Keratoderma 49 55
Aquagenic Wrinkling of the Palms 49 55
Aquagenic Keratoderma 49 55
Aquagenic Syringeal Acrokeratoderma 55
Aquagenic Wrinkling of the Hands 49

Classifications:



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Summaries for Aquagenic Syringeal Acrokeratoderm

NIH Rare Diseases : 49 Aquagenic syringeal acrokeratoderma is a rare condition affecting the palms of the hands. It is characterized by the appearance or worsening of a palmar eruption, following brief exposure to water. The palmar eruption is made up of small, white or shining pimples that can conjoin into plaques. The feet are unaffected. Symptoms include a burning pain and a tightening sensation in the palms, as well as too much sweating. There are two variants. Most commonly, it is a temporary and recurrent condition that appears after submersion in water, known as the “hand in the bucket sign,” that gets better within minutes to hours of drying. A less common variant is characterized by persistent lesions that are worsened after water submersion. The cause of aquagenic syringeal acrokeratoderma is unknown, but likely relates to sweating. Several studies have found that it is present in about 40% to 84% of cystic fibrosis patients and also in carriers, which suggest that it may be caused by mutations in the CFTR gene. It is more often found in young women. Besides cystic fibrosis, it is also seen in wasting (marasmus) and nephrotic syndrome and also with the use of aspirin and other drugs such as rofecoxib and celecoxib. In most cases it does not need any treatment and resolves spontaneously. When necessary, it can be treated with topical aluminum chloride or salicylic acid ointment or with tap water iontophoresis. Last updated: 4/19/2016

MalaCards based summary : Aquagenic Syringeal Acrokeratoderm, also known as transient reactive papulotranslucent acrokeratoderma, is related to wrinkles and cystic fibrosis.

Related Diseases for Aquagenic Syringeal Acrokeratoderm

Diseases related to Aquagenic Syringeal Acrokeratoderm via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 wrinkles 10.5
2 cystic fibrosis 10.0

Symptoms & Phenotypes for Aquagenic Syringeal Acrokeratoderm

Drugs & Therapeutics for Aquagenic Syringeal Acrokeratoderm

Search Clinical Trials , NIH Clinical Center for Aquagenic Syringeal Acrokeratoderm

Genetic Tests for Aquagenic Syringeal Acrokeratoderm

Anatomical Context for Aquagenic Syringeal Acrokeratoderm

Publications for Aquagenic Syringeal Acrokeratoderm

Articles related to Aquagenic Syringeal Acrokeratoderm:

# Title Authors Year
1
Non-steroidal anti-inflammatory drug - induced transient reactive papulotranslucent acrokeratoderma. ( 24653762 )
2014
2
Atypical form of transient reactive papulotranslucent acrokeratoderma in a cystic fibrosis carrier. ( 23379606 )
2013
3
Atypical form of transient reactive papulotranslucent acrokeratoderma: a case report and review of the literature. ( 21128920 )
2010
4
Transient reactive papulotranslucent acrokeratoderma in a 50-year-old woman: case report and review of the literature. ( 18973409 )
2008
5
Unilateral transient reactive papulotranslucent acrokeratoderma in a child. ( 17958817 )
2007

Variations for Aquagenic Syringeal Acrokeratoderm

Expression for Aquagenic Syringeal Acrokeratoderm

Search GEO for disease gene expression data for Aquagenic Syringeal Acrokeratoderm.

Pathways for Aquagenic Syringeal Acrokeratoderm

GO Terms for Aquagenic Syringeal Acrokeratoderm

Sources for Aquagenic Syringeal Acrokeratoderm

3 CDC
7 CNVD
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10 dbSNP
11 DGIdb
16 ExPASy
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58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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