MCID: ARC007
MIFTS: 38

Arachnoid Cysts malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases, Fetal diseases

Aliases & Classifications for Arachnoid Cysts

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Sources:
27GTR, 31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 49NINDS, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Arachnoid Cysts:

Name: Arachnoid Cysts 48 49 68
Intracranial Arachnoid Cysts 48 27 68
 
Arachnoid Cyst 54 27
Arachnoid Cysts, Intracranial 48

Characteristics:

Orphanet epidemiological data:

54
arachnoid cyst:
Inheritance: Autosomal recessive,Not applicable; Age of onset: Childhood; Age of death: normal life expectancy

Classifications:



External Ids:

Orphanet54 ORPHA2356
UMLS via Orphanet69 C0078981
MESH via Orphanet40 D016080
ICD10 via Orphanet31 G93.0

Summaries for Arachnoid Cysts

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NIH Rare Diseases:48 Arachnoid cysts are sacs filled with cerebrospinal fluid (CSF) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. Arachnoid cysts can be primary or secondary. Primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. Secondary arachnoid cysts are less common and result from head injuries, meningitis, tumors, or as a complication of brain surgery. Signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. Although many affected individuals develop symptoms in the first year of life, some never develop symptoms. Whether and how to treat the condition depends on the location and size of the cyst.  When treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the CSF. Last updated: 1/7/2016

MalaCards based summary: Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to spinal intradural arachnoid cysts and pachygyria with mental retardation, seizures, and arachnoid cysts. An important gene associated with Arachnoid Cysts is NRAS (Neuroblastoma RAS Viral Oncogene Homolog), and among its related pathways is AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include spinal cord, brain and temporal lobe, and related mouse phenotypes are Decreased shRNA abundance (Z-score < -2) and cardiovascular system.

NINDS:49 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.

Wikipedia:71 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Related Diseases for Arachnoid Cysts

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Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to arachnoid cysts

Symptoms & Phenotypes for Arachnoid Cysts

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GenomeRNAi Phenotypes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-589.4NRAS, SLC12A2

MGI Mouse Phenotypes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053859.2COL4A1, FOXC2, NRAS, SLC12A2

Drugs & Therapeutics for Arachnoid Cysts

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Drugs for Arachnoid Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Mentholapproved23532216-51-516666
Synonyms:
(−
()-Menthol
(+)-Neo-menthol
(+)-p-Menthan-3-ol
(+-)-(1R*,3R*,4S*)-Menthol
(+-)-Menthol
(+/-)-Menthol
(+/-)-p-Menthan-3-ol
(-)-(1R,3R,4S)-Menthol
(-)-Menthyl alcohol
(-)-menthol
(-)-p-Menthan-3-ol
(-)-trans-p-Menthan-cis-ol
(1R)-(-)-Menthol
(1R,2S,5R)-(-)-menthol
(1R,2S,5R)-Menthol
(1R,3R,4S)-(-)-MENTHOL
(1R,3R,4S)-(-)-Menthol
(1R-(1-alpha,2-beta,5-alpha))-5-Methyl-2-(1-methylethyl)cyclohexanol
(1S, 2S, 5R)-(+)-Neomenthol
(1S,2R,5R)-(+)-Isomenthol
(1S,2R,5S)-(+)-Menthol
(1S,2R,5S)-Menthol
(1alpha,2beta,5alpha)-5-Methyl-2(1-methylethyl)cyclohexanol
(1r,2s,5r)-(-)-menthol
(L)-MENTHOL
(R)-(-)-Menthol
(r)-(-)-menthol
)-Menthol
--MENTHOL
1-Menthol
1490-04-6
15356-60-2
15356-70-4
15785_RIEDEL
15785_SIAL
19863P
2-Isopropyl-5-methylcyclohexanol
20747-49-3
2216-51-5
3-p-Menthol
4-Isopropyl-1-methylcyclohexan-3-ol
491-02-1
5-Methyl-2-(1-methylethyl)-cyclohexanol
5-Methyl-2-(1-methylethyl)cyclohexanol
5-methyl-2-(propan-2-yl)cyclohexanol
5-methyl-2-propan-2-ylcyclohexan-1-ol
551376_ALDRICH
551376_FLUKA
588733_ALDRICH
613290_ALDRICH
613290_FLUKA
63660_FLUKA
63670_ALDRICH
63670_FLUKA
63975-60-0
6C6A4A8C-A054-468C-A1F0-F29E39838CF2
89-78-1
98167-53-4
AC1L1B2E
AC1L28FR
AC1Q1NQ2
AC1Q2QQM
AI3-08161
AI3-52408
AKOS000119740
AR-1J3337
BB_NC-0057
BRN 1902288
BRN 3194263
BSPBio_003062
C00400
C10H20O
CCRIS 3728
CCRIS 375
CCRIS 4666
CCRIS 9231
CHEBI:15409
CHEBI:545611
CHEMBL256087
CHEMBL470670
CID1254
CID16666
Caswell No. 540
D-(-)-Menthol
D-p-Menthan-3-ol
D00064
D008610
D04849
D04918
DB00825
DivK1c_000820
EINECS 201-939-0
EINECS 207-724-8
EINECS 216-074-4
EINECS 218-690-9
EINECS 239-387-8
EINECS 239-388-3
EPA Pesticide Chemical Code 051601
FEMA No. 2665
Fisherman's friend lozenges
Fisherman's friend lozenges (TN)
HMS1922G13
HMS2092L14
HMS502I22
 
HSDB 5662
HSDB 593
Headache crystals
Hexahydrothymol
I06-1216
I14-7371
IDI1_000820
KBio1_000820
KBio2_000785
KBio2_003353
KBio2_005921
KBio3_002562
KBioSS_000785
L-(-)-Menthol
L-(-)-menthol
L-Menthol
L-menthol
LMPR0102090001
LS-2353
LS-57201
LS-886
LS-89531
LS-89533
Levomenthol
Levomenthol [INN:BAN]
Levomentholum
Levomentholum [INN-Latin]
Levomentol
M0321
M0545
M2772_SIAL
MENTHOL
MLS002207256
Menthacamphor
Menthol
Menthol (USP)
Menthol (VAN)
Menthol natural
Menthol natural, brazilian
Menthol racemic
Menthol racemique
Menthol racemique [French]
Menthol solution
Menthol, (1alpha,2beta,5alpha)-Isomer
Menthomenthol
Menthyl alcohol
MolPort-000-849-729
MolPort-001-793-392
NCGC00159382-02
NCGC00159382-03
NCGC00164247-01
NCGC00164247-02
NCI-C50000
NINDS_000820
NOOLISFMXDJSKH-KXUCPTDWBX
NSC 2603
NSC 62788
NSC2603
NSC62788
Neoisomenthol
Peppermint camphor
RACEMIC MENTHOL U.S.P.
Racementhol
Racementhol [INN:BAN]
Racementholum
Racementholum [INN-Latin]
Racementol
Racementol [INN-Spanish]
Racemic menthol
Robitussin Cough Drops
SDCCGMLS-0066659.P001
SMR001306785
SPBio_000869
SPECTRUM1503134
STK802468
Spectrum2_000855
Spectrum3_001561
Spectrum5_001060
Spectrum_000305
Tra-kill tracheal mite killer
U.S.P. Menthol
U.S.p. Menthol
UNII-BZ1R15MTK7
UNII-L7T10EIP3A
UNII-YS08XHA860
W266507_ALDRICH
W266523_ALDRICH
W266590_ALDRICH
WLN: L6TJ AY1&1 BQ D1
WLN: L6TJ AY1&1 DQ D1 -L
ZINC01482164
cis-1 ,3-trans-1,4-(+-)-menthol
cis-1,3-trans-1,4-(+-)-menthol
d,l-Menthol
d-Menthol
d-Neomenthol
dl-3-p-Menthanol
dl-Menthol
dl-Menthol (JP15)
l-(-)-Menthol
l-Menthol
l-Menthol (JP15)
l-Menthol (TN)
l-Menthol (natural)
nchembio862-comp1
p-Menthan-3-ol
rac-Menthol

Interventional clinical trials:

idNameStatusNCT IDPhase
1Study and Surgical Treatment of SyringomyeliaCompletedNCT00011245
2Treatment for Chronic Spinal Cord Injury: Surgery With Rehabilitation vs RehabilitationRecruitingNCT02663310

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

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Genetic tests related to Arachnoid Cysts:

id Genetic test Affiliating Genes
1 Arachnoid Cyst27
2 Arachnoid Cysts, Intracranial27

Anatomical Context for Arachnoid Cysts

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MalaCards organs/tissues related to Arachnoid Cysts:

36
Spinal cord, Brain, Temporal lobe, Pituitary, Cingulate cortex, Testis, Kidney

Publications for Arachnoid Cysts

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Articles related to Arachnoid Cysts:

(show top 50)    (show all 663)
idTitleAuthorsYear
1
Episodic Headache and Arachnoid Cyst Related Subdural Hematoma. (27197943)
2016
2
Prevalence and symptoms of intracranial arachnoid cysts: a population-based study. (26860092)
2016
3
Pediatric intraventricular arachnoid cysts in the body of lateral ventricle: surgical outcome and its embryologic background. (27492334)
2016
4
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. (26882854)
2016
5
Treatment of Middle Cranial Fossa Arachnoid Cysts: A Systematic Review and Meta-Analysis. (27319312)
2016
6
Sports participation with arachnoid cysts. (26636254)
2016
7
Transfrontal Transaqueductal, Transtrigonal, and Suboccipital Infratentorial Supracerebellar Endoscopic Fenestration of Posterior Fossa Arachnoid Cysts: Three Surgical Cases. (26968147)
2016
8
Supraorbital Keyhole Microsurgical Fenestration of Symptomatic Temporal Arachnoid Cysts in Children: Advantages and Limitations. (27873293)
2016
9
Surgery for intracranial arachnoid cysts in children-a prospective long-term study. (27000761)
2016
10
Motor Speech Apraxia in a 70-Year-Old Man with Left Dorsolateral Frontal Arachnoid Cyst: A [(18)F]FDG PET-CT Study. (28003922)
2016
11
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? (27406556)
2016
12
Septooptic Dysplasia with an Associated Arachnoid Cyst. (27891281)
2016
13
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? (27379494)
2016
14
Sport-related structural brain injury associated with arachnoid cysts: a systematic review and quantitative analysis. (27032926)
2016
15
Assessment of endoscopic treatment for quadrigeminal cistern arachnoid cysts: A 7-year experience with 28 cases. (26590025)
2016
16
Low-Cost Interactive Image-Based Virtual Endoscopy for the Diagnosis and Surgical Planning of Suprasellar Arachnoid Cysts. (26732948)
2016
17
Letter to the Editor: Are arachnoid cysts and Chiari malformation Type I more common in those with postconcussion syndrome? (27611207)
2016
18
Spinal extradural arachnoid cyst: A rare cause of neurogenic bladder. (27365974)
2016
19
Atypical cause of radiculopathy - Intradural spinal arachnoid cyst. (27104760)
2016
20
The Acetazolamide Challenge: A Tool for Surgical Decision Making and Predicting Surgical Outcome in Patients with Arachnoid Cysts. (27415592)
2016
21
Digital Subtraction Cystography for Detection of Communicating Holes of Spinal Extradural Arachnoid Cysts. (26798223)
2016
22
Transsacrococcygeal approach to ganglion impar block for treatment of chronic coccygodynia after spinal arachnoid cyst removal: A case report. (27684866)
2016
23
Children With Arachnoid Cysts Who Sustain Blunt Head Trauma: Injury Mechanisms and Outcomes. (26728086)
2016
24
Intramedullary cyst formation after removal of multiple intradural spinal arachnoid cysts: A case report. (27512608)
2016
25
Comparative analysis of bleeding risk by the location and shape of arachnoid cysts: a finite element model analysis. (27718069)
2016
26
Clinical and Radiographical Differences Between Thoracic Idiopathic Spinal Cord Herniation and Spinal Arachnoid Cyst. (27926670)
2016
27
Radiological diagnosis of spinal arachnoid cysts: A pictorial essay. (27160059)
2016
28
Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region. (26728365)
2016
29
Bilateral middle cranial fossa arachnoidal cysts with temporal lobe agenesis associated with astrocytoma: fortuitous finding. (25715752)
2015
30
Multiple Spinal Arachnoid Cysts in a Child. (25987363)
2015
31
Outcome of 12 antenatally diagnosed fetal arachnoid cysts: case series and review of the literature. (25599983)
2015
32
Bell's palsy in association with a cerebellar arachnoid cyst. (25878242)
2015
33
Hemifacial spasm caused by a cerebellopontine angle arachnoid cyst. Case report and literature review. (26165486)
2015
34
Surgical Decompression of Arachnoid Cysts Leads to Improved Quality of Life: A Prospective Study. (26540351)
2015
35
Spinal Extradural Arachnoid Cysts: A Series of 10 Cases. (26008955)
2015
36
A symptomatic spinal extradural arachnoid cyst with lumbar disc herniation. (25861499)
2015
37
Ventriculoscopic surgery for arachnoid cysts in the lateral ventricle: a comparative study of 21 consecutive cases. (26885002)
2015
38
Exploring predictors of surgery and comparing operative treatment approaches for pediatric intracranial arachnoid cysts: a case series of 83 patients. (26067335)
2015
39
Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst. (26545093)
2015
40
Clinical characteristics and treatment strategies for idiopathic spinal extradural arachnoid cysts: a single-center experience. (25520051)
2015
41
Suprasellar Arachnoid Cysts: Toward a New Simple Classification Based on Prognosis and Treatment Modality. (26445374)
2015
42
Neuroendoscopy for Intracranial Arachnoid Cysts in Infants: Therapeutic Considerations. (26241198)
2015
43
Chronic Subdural Hematomas Associated with Arachnoid Cysts: Significance in Young Patients with Chronic Subdural Hematomas. (26345665)
2015
44
The effectiveness of microsurgical fenestration for middle fossa arachnoid cysts in children. (26424732)
2015
45
Neuroendoscopic treatment for hydrocephalus associated to midline arachnoid cysts in a series of nine pediatric patients. (26041004)
2015
46
Children With Intracranial Arachnoid Cysts: Classification and Treatment. (26554773)
2015
47
Shunt placement after cyst fenestration for middle cranial fossa arachnoid cysts in children. (26230463)
2015
48
Analysis on clinical characteristics of intracranial Arachnoid Cysts in 488 pediatric cases. (26770437)
2015
49
Endoscopic Treatment of Temporal Arachnoid Cysts in 34 Patients. (25968965)
2015
50
Clinical and radiological outcomes of surgical treatment for symptomatic arachnoid cysts in adults. (26154148)
2015

Variations for Arachnoid Cysts

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Copy number variations for Arachnoid Cysts from CNVD:

6 (show all 32)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
141643102182284821949193LossC10orf114Intracranial arachnoid cysts
241644102182284821949193LossC10orf140Intracranial arachnoid cysts
341645102182284821949193LossMLLT10Intracranial arachnoid cysts
457050116255772462669857LossSLC22A24Intracranial arachnoid cysts
56386512121446657121547275Copy numberCLIP1Intracranial arachnoid cysts
66386612121446657121547275Copy numberZCCHC8Intracranial arachnoid cysts
768816125172407351844567LossCSADIntracranial arachnoid cysts
868817125172407351844567LossIGFBP6Intracranial arachnoid cysts
968818125172407351844567LossSOAT2Intracranial arachnoid cysts
1068819125172407351844567LossSPRYD3Intracranial arachnoid cysts
1168820125172407351844567LossTENC1Intracranial arachnoid cysts
1270825126497848765093419GainITGB7Intracranial arachnoid cysts
1370828126497848765093419GainZNF740Intracranial arachnoid cysts
1486768146497848765093419InversionFUT8Intracranial arachnoid cysts
1592669154246849142598658Copy numberCASC4Intracranial arachnoid cysts
1692670154246849142598658Copy numberCTDSPL2Intracranial arachnoid cysts
171012201634316563522375Copy numberC16orf90Intracranial arachnoid cysts
181012211634316563522375Copy numberCLUAP1Intracranial arachnoid cysts
191013801635223753631656LossBTBD12Intracranial arachnoid cysts
201013821635223753631656LossNLRC3Intracranial arachnoid cysts
2110672617110700000LossTP53Intracranial arachnoid cysts
22112317173856062738814457LossLOC100130581Intracranial arachnoid cysts
23112318173856062738814457LossNBR1Intracranial arachnoid cysts
24112319173856062738814457LossTMEM106AIntracranial arachnoid cysts
251248201912057971228434LossSTK11Intracranial arachnoid cysts
26125526191424673414391382LossCD97Intracranial arachnoid cysts
27125527191424673414391382LossDDX39Intracranial arachnoid cysts
28227152764982076600621DeletionC7orf26Intracranial arachnoid cysts
29227153764982076600621DeletionGRID2IPIntracranial arachnoid cysts
30227154764982076600621DeletionZDHHC4Intracranial arachnoid cysts
3123369981270000019000000LossN33Intracranial arachnoid cysts
3223985684217520642281148Copy numberPLATIntracranial arachnoid cysts

Expression for genes affiliated with Arachnoid Cysts

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Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for genes affiliated with Arachnoid Cysts

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Pathways related to Arachnoid Cysts according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
19.5COL4A1, NRAS

GO Terms for genes affiliated with Arachnoid Cysts

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Biological processes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

   (show less)
idNameGO IDTop Affiliating Genes

Sources for Arachnoid Cysts

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet