MCID: ARC007
MIFTS: 39

Arachnoid Cysts

Categories: Rare diseases, Neuronal diseases, Endocrine diseases, Fetal diseases

Aliases & Classifications for Arachnoid Cysts

MalaCards integrated aliases for Arachnoid Cysts:

Name: Arachnoid Cysts 49 50 69
Intracranial Arachnoid Cysts 49 69
Arachnoid Cyst 55 28
Arachnoid Cysts, Intracranial 49

Characteristics:

Orphanet epidemiological data:

55
arachnoid cyst
Inheritance: Autosomal recessive,Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 55 ORPHA2356
MESH via Orphanet 42 D016080
UMLS via Orphanet 70 C0078981
ICD10 via Orphanet 33 G93.0

Summaries for Arachnoid Cysts

NINDS : 50 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.   Primary arachnoid cysts are present at birth and are the result of developmental abnormalities in the brain and spinal cord that arise during the early weeks of gestation.  Secondary arachnoid cysts are not as common as primary cysts and develop as a result of head injury, meningitis, or tumors, or as a complication of brain surgery.  The majority of arachnoid cysts form outside the temporal lobe of the brain in an area of the skull known as the middle cranial fossa.  Arachnoid cysts involving the spinal cord are rarer.  The location and size of the cyst determine the symptoms and when those symptoms begin.  Most individuals with arachnoid cysts develop symptoms before the age of 20, and especially during the first year of life, but some people with arachnoid cysts never have symptoms.  Males are four times more likely to have arachnoid cysts than females.  Typical symptoms of an arachnoid cyst around the brain include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking.  Arachnoid cysts around the spinal cord compress the spinal cord or nerve roots and cause symptoms such as progressive back and leg pain and tingling or numbness in the legs or arms.  Diagnosis usually involves a brain scan or spine scan using diffusion-weighted MRI (magnetic resonance imaging) which helps distinguish fluid-filled arachnoid cysts from other types of cysts.   

MalaCards based summary : Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to spinal intradural arachnoid cysts and tibia absent polydactyly arachnoid cyst. An important gene associated with Arachnoid Cysts is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways is AGE-RAGE signaling pathway in diabetic complications. Affiliated tissues include spinal cord, brain and temporal lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

NIH Rare Diseases : 49 Arachnoid cysts are sacs filled with cerebrospinal fluid (CSF) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. Arachnoid cysts can be primary or secondary. Primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. Secondary arachnoid cysts are less common, and result from head injuries, meningitis, tumors, or as a complication of brain surgery. Signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. Although many affected individuals develop symptoms in the first year of life, some never develop symptoms. Whether and how to treat the condition depends on the location and size of the cyst. In some cases, arachnoid cysts are part of a genetic syndrome such as Chudley-McCullough syndrome, mucopolysaccharidosis, or Marfan syndrome, where there are many other associated signs and symptoms. When treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the CSF. Last updated: 12/14/2017

Wikipedia : 72 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Related Diseases for Arachnoid Cysts

Diseases related to Arachnoid Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 spinal intradural arachnoid cysts 12.6
2 tibia absent polydactyly arachnoid cyst 12.5
3 arachnoid cysts, intracranial 12.3
4 pachygyria with mental retardation, seizures, and arachnoid cysts 12.3
5 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.1
6 intracranial cysts 11.5
7 melanosis, neurocutaneous 11.5
8 chudley-mccullough syndrome 11.4
9 arachnoiditis 11.1
10 retrocerebellar cyst 11.1
11 acrocallosal syndrome 11.0
12 encephalocraniocutaneous lipomatosis 11.0
13 spinal arachnoiditis 10.5
14 syringomyelia 10.3
15 hydrocephalus 10.3
16 cerebritis 10.1
17 headache 10.1
18 cervicitis 10.1
19 epilepsy 10.1
20 cauda equina syndrome 10.0
21 obstructive hydrocephalus 10.0
22 bobble-head doll syndrome 10.0
23 cranial nerve palsy 10.0
24 meningitis 10.0
25 distichiasis 9.9
26 trigeminal neuralgia 9.9
27 hydrocephalus, nonsyndromic, autosomal recessive 1 9.9
28 hydrocephalus, normal-pressure 9.9
29 aging 9.9
30 hydrocephalus, nonsyndromic, autosomal recessive 2 9.9
31 lymphedema 9.9
32 meningocele 9.9
33 precocious puberty 9.9
34 head injury 9.9
35 hemifacial spasm 9.9
36 spasticity 9.9
37 syringohydromyelia 9.9
38 spondyloarthropathy 1 9.8
39 facial spasm 9.8
40 lipomatosis, multiple 9.8
41 migraine with or without aura 1 9.8
42 optic nerve hypoplasia, bilateral 9.8
43 septooptic dysplasia 9.8
44 neural tube defects 9.8
45 tuberous sclerosis 1 9.8
46 corpus callosum, agenesis of 9.8
47 dandy-walker syndrome 9.8
48 schizencephaly 9.8
49 meningioma, familial 9.8
50 episodic pain syndrome, familial, 1 9.8

Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to Arachnoid Cysts

Symptoms & Phenotypes for Arachnoid Cysts

GenomeRNAi Phenotypes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.23 SLC12A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 NRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.23 SLC12A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.23 NRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.23 NRAS SLC12A2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 SLC12A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.23 NRAS

MGI Mouse Phenotypes related to Arachnoid Cysts:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 COL4A1 FOXC2 NRAS SLC12A2
2 hearing/vestibular/ear MP:0005377 8.8 FOXC2 SLC12A2 SPAST

Drugs & Therapeutics for Arachnoid Cysts

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study and Surgical Treatment of Syringomyelia Completed NCT00011245

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

Genetic tests related to Arachnoid Cysts:

# Genetic test Affiliating Genes
1 Arachnoid Cyst 28

Anatomical Context for Arachnoid Cysts

MalaCards organs/tissues related to Arachnoid Cysts:

38
Spinal Cord, Brain, Temporal Lobe, Pituitary, Cingulate Cortex, Testis, Kidney

Publications for Arachnoid Cysts

Articles related to Arachnoid Cysts:

(show top 50) (show all 688)
# Title Authors Year
1
Development of Neuromyelitis Optica Spectrum Disorder and Spinal Arachnoid Cysts in a Patient With Intractable Epilepsy. ( 29379967 )
2018
2
The Transcondylar Approach to Access Symptomatic Arachnoid Cysts of the Hypoglossal Canal. ( 29351690 )
2018
3
Surgical management of cerebellopontine angle arachnoid cysts associated with hearing deficit in pediatric patients. ( 29171799 )
2018
4
Hemorrhagic complications of arachnoid cysts: When, Why and Who? ( 29410376 )
2018
5
Spontaneous repeated disappearance and recurrence of multiple spinal intradural arachnoid cysts in a child. ( 29325964 )
2018
6
Temporal arachnoid cysts: are they congenital? ( 29046949 )
2018
7
Long-term endocrine outcome of suprasellar arachnoid cysts. ( 28338427 )
2017
8
Idiopathic intradural dorsal thoracic arachnoid cysts: A case series and review of the literature. ( 28318981 )
2017
9
The association of arachnoid cysts and focal epilepsy: Hospital based case control study. ( 28527977 )
2017
10
Bobble-head doll syndrome in an 80-year-old man, associated with a giant arachnoid cyst of the lamina quadrigemina, treated with endoscopic ventriculocystocisternotomy and cystoperitoneal shunt. ( 28488069 )
2017
11
Clinical and Radiologic Outcomes After Fenestration and Partial Wall Excision of Idiopathic Intradural Spinal Arachnoid Cysts Presenting with Myelopathy. ( 28578118 )
2017
12
Sonographic diagnosis and prognosis of fetal arachnoid cysts. ( 28984371 )
2017
13
Antenatally diagnosed pre-pontine arachnoid cysts with significant post-natal supratentorial progression: report of two cases. ( 28918519 )
2017
14
Endoscopic surgery for intraventricular arachnoid cysts in children: clinical presentation, radiological features, management, and outcomes over a 12-year period. ( 28717832 )
2017
15
A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts. ( 28327950 )
2017
16
Management of quadrigeminal arachnoid cyst associated with obstructive hydrocephalus: report on stereotactic ventricular - cystic stenting. ( 28643523 )
2017
17
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
18
Arachnoid Cysts And Adult Onset Epilepsy. ( 28246242 )
2017
19
Endoscopic treatment of middle fossa arachnoid cysts. ( 28905234 )
2017
20
Spinal arachnoid cysts - our experience and review of literature. ( 28287894 )
2017
21
Conus Medullaris Arachnoid Cyst Presenting as Cauda Equina Syndrome. ( 29114289 )
2017
22
Does subjective improvement in adults with intracranial arachnoid cysts justify surgical treatment? ( 28298013 )
2017
23
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27379494 )
2016
24
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
25
Comparative analysis of bleeding risk by the location and shape of arachnoid cysts: a finite element model analysis. ( 27718069 )
2016
26
Radiological diagnosis of spinal arachnoid cysts: A pictorial essay. ( 27160059 )
2016
27
Transsacrococcygeal approach to ganglion impar block for treatment of chronic coccygodynia after spinal arachnoid cyst removal: A case report. ( 27684866 )
2016
28
Assessment of endoscopic treatment for quadrigeminal cistern arachnoid cysts: A 7-year experience with 28 cases. ( 26590025 )
2016
29
Sports participation with arachnoid cysts. ( 26636254 )
2016
30
Atypical cause of radiculopathy - Intradural spinal arachnoid cyst. ( 27104760 )
2016
31
Digital Subtraction Cystography for Detection of Communicating Holes of Spinal Extradural Arachnoid Cysts. ( 26798223 )
2016
32
Motor Speech Apraxia in a 70-Year-Old Man with Left Dorsolateral Frontal Arachnoid Cyst: A [(18)F]FDG PET-CT Study. ( 28003922 )
2016
33
Sport-related structural brain injury associated with arachnoid cysts: a systematic review and quantitative analysis. ( 27032926 )
2016
34
Treatment of Middle Cranial Fossa Arachnoid Cysts: A Systematic Review and Meta-Analysis. ( 27319312 )
2016
35
Letter to the Editor: Are arachnoid cysts and Chiari malformation Type I more common in those with postconcussion syndrome? ( 27611207 )
2016
36
Pediatric intraventricular arachnoid cysts in the body of lateral ventricle: surgical outcome and its embryologic background. ( 27492334 )
2016
37
Surgery for intracranial arachnoid cysts in children-a prospective long-term study. ( 27000761 )
2016
38
Supraorbital Keyhole Microsurgical Fenestration of Symptomatic Temporal Arachnoid Cysts in Children: Advantages and Limitations. ( 27873293 )
2016
39
Septooptic Dysplasia with an Associated Arachnoid Cyst. ( 27891281 )
2016
40
Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region. ( 26728365 )
2016
41
Intramedullary cyst formation after removal of multiple intradural spinal arachnoid cysts: A case report. ( 27512608 )
2016
42
Children With Arachnoid Cysts Who Sustain Blunt Head Trauma: Injury Mechanisms and Outcomes. ( 26728086 )
2016
43
Clinical and Radiographical Differences Between Thoracic Idiopathic Spinal Cord Herniation and Spinal Arachnoid Cyst. ( 27926670 )
2016
44
The Acetazolamide Challenge: A Tool for Surgical Decision Making and Predicting Surgical Outcome in Patients with Arachnoid Cysts. ( 27415592 )
2016
45
Transfrontal Transaqueductal, Transtrigonal, and Suboccipital Infratentorial Supracerebellar Endoscopic Fenestration of Posterior Fossa Arachnoid Cysts: Three Surgical Cases. ( 26968147 )
2016
46
Spinal extradural arachnoid cyst: A rare cause of neurogenic bladder. ( 27365974 )
2016
47
Episodic Headache and Arachnoid Cyst Related Subdural Hematoma. ( 27197943 )
2016
48
Prevalence and symptoms of intracranial arachnoid cysts: a population-based study. ( 26860092 )
2016
49
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27406556 )
2016
50
Low-Cost Interactive Image-Based Virtual Endoscopy for the Diagnosis and Surgical Planning of Suprasellar Arachnoid Cysts. ( 26732948 )
2016

Variations for Arachnoid Cysts

Copy number variations for Arachnoid Cysts from CNVD:

7 (show all 32)
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41643 10 21822848 21949193 Loss C10orf114 Intracranial arachnoid cysts
2 41644 10 21822848 21949193 Loss C10orf140 Intracranial arachnoid cysts
3 41645 10 21822848 21949193 Loss MLLT10 Intracranial arachnoid cysts
4 57050 11 62557724 62669857 Loss SLC22A24 Intracranial arachnoid cysts
5 63865 12 121446657 121547275 Copy number CLIP1 Intracranial arachnoid cysts
6 63866 12 121446657 121547275 Copy number ZCCHC8 Intracranial arachnoid cysts
7 68816 12 51724073 51844567 Loss CSAD Intracranial arachnoid cysts
8 68817 12 51724073 51844567 Loss IGFBP6 Intracranial arachnoid cysts
9 68818 12 51724073 51844567 Loss SOAT2 Intracranial arachnoid cysts
10 68819 12 51724073 51844567 Loss SPRYD3 Intracranial arachnoid cysts
11 68820 12 51724073 51844567 Loss TENC1 Intracranial arachnoid cysts
12 70825 12 64978487 65093419 Gain ITGB7 Intracranial arachnoid cysts
13 70828 12 64978487 65093419 Gain ZNF740 Intracranial arachnoid cysts
14 86768 14 64978487 65093419 Inversion FUT8 Intracranial arachnoid cysts
15 92669 15 42468491 42598658 Copy number CASC4 Intracranial arachnoid cysts
16 92670 15 42468491 42598658 Copy number CTDSPL2 Intracranial arachnoid cysts
17 101220 16 3431656 3522375 Copy number C16orf90 Intracranial arachnoid cysts
18 101221 16 3431656 3522375 Copy number CLUAP1 Intracranial arachnoid cysts
19 101380 16 3522375 3631656 Loss BTBD12 Intracranial arachnoid cysts
20 101382 16 3522375 3631656 Loss NLRC3 Intracranial arachnoid cysts
21 106726 17 1 10700000 Loss TP53 Intracranial arachnoid cysts
22 112317 17 38560627 38814457 Loss LOC100130581 Intracranial arachnoid cysts
23 112318 17 38560627 38814457 Loss NBR1 Intracranial arachnoid cysts
24 112319 17 38560627 38814457 Loss TMEM106A Intracranial arachnoid cysts
25 124820 19 1205797 1228434 Loss STK11 Intracranial arachnoid cysts
26 125526 19 14246734 14391382 Loss CD97 Intracranial arachnoid cysts
27 125527 19 14246734 14391382 Loss DDX39 Intracranial arachnoid cysts
28 227152 7 6498207 6600621 Deletion C7orf26 Intracranial arachnoid cysts
29 227153 7 6498207 6600621 Deletion GRID2IP Intracranial arachnoid cysts
30 227154 7 6498207 6600621 Deletion ZDHHC4 Intracranial arachnoid cysts
31 233699 8 12700000 19000000 Loss N33 Intracranial arachnoid cysts
32 239856 8 42175206 42281148 Copy number PLAT Intracranial arachnoid cysts

Expression for Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for Arachnoid Cysts

Pathways related to Arachnoid Cysts according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.62 COL4A1 NRAS

GO Terms for Arachnoid Cysts

Biological processes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 branching involved in blood vessel morphogenesis GO:0001569 8.62 COL4A1 FOXC2

Sources for Arachnoid Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....