MCID: ARC007
MIFTS: 39

Arachnoid Cysts malady

Categories: Rare diseases, Neuronal diseases, Endocrine diseases, Fetal diseases

Aliases & Classifications for Arachnoid Cysts

Aliases & Descriptions for Arachnoid Cysts:

Name: Arachnoid Cysts 50 51 69
Intracranial Arachnoid Cysts 50 29 69
Arachnoid Cyst 56 29
Arachnoid Cysts, Intracranial 50

Characteristics:

Orphanet epidemiological data:

56
arachnoid cyst
Inheritance: Autosomal recessive,Not applicable; Age of onset: Childhood; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 56 ORPHA2356
UMLS via Orphanet 70 C0078981
MESH via Orphanet 43 D016080
ICD10 via Orphanet 34 G93.0

Summaries for Arachnoid Cysts

NIH Rare Diseases : 50 arachnoid cysts are sacs filled with cerebrospinal fluid (csf) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. arachnoid cysts can be primary or secondary. primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. secondary arachnoid cysts are less common and result from head injuries, meningitis, tumors, or as a complication of brain surgery. signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. although many affected individuals develop symptoms in the first year of life, some never develop symptoms. whether and how to treat the condition depends on the location and size of the cyst.  when treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the csf. last updated: 1/7/2016

MalaCards based summary : Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to spinal intradural arachnoid cysts and pachygyria with mental retardation, seizures, and arachnoid cysts. An important gene associated with Arachnoid Cysts is FOXC2 (Forkhead Box C2), and among its related pathways/superpathways is AGE-RAGE signaling pathway in diabetic complications. The drug Menthol has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and cardiovascular system

NINDS : 51 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.   Primary arachnoid cysts are present at birth and are the result of developmental abnormalities in the brain and spinal cord that arise during the early weeks of gestation.  Secondary arachnoid cysts are not as common as primary cysts and develop as a result of head injury, meningitis, or tumors, or as a complication of brain surgery.  The majority of arachnoid cysts form outside the temporal lobe of the brain in an area of the skull known as the middle cranial fossa.  Arachnoid cysts involving the spinal cord are rarer.  The location and size of the cyst determine the symptoms and when those symptoms begin.  Most individuals with arachnoid cysts develop symptoms before the age of 20, and especially during the first year of life, but some people with arachnoid cysts never have symptoms.  Males are four times more likely to have arachnoid cysts than females. 

Wikipedia : 71 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Related Diseases for Arachnoid Cysts

Diseases related to Arachnoid Cysts via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 146)
id Related Disease Score Top Affiliating Genes
1 spinal intradural arachnoid cysts 12.4
2 pachygyria with mental retardation, seizures, and arachnoid cysts 12.2
3 tibia absent polydactyly arachnoid cyst 12.1
4 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 12.0
5 intracranial cysts 11.4
6 chudley-mccullough syndrome 11.3
7 neurocutaneous melanosis, somatic 11.1
8 arachnoiditis 11.0
9 spinal arachnoiditis 10.4
10 syringomyelia 10.2
11 hydrocephalus 10.2
12 cerebritis 10.1
13 headache 10.1
14 cervicitis 10.0
15 obstructive hydrocephalus 9.9
16 bobble-head doll syndrome 9.9
17 cauda equina syndrome 9.9
18 cranial nerve palsy 9.9
19 epilepsy 9.9
20 spasticity 9.8
21 lymphedema 9.8
22 precocious puberty 9.8
23 syringohydromyelia 9.8
24 normal pressure hydrocephalus 9.8
25 meningitis 9.8
26 trigeminal neuralgia 9.8
27 head injury 9.8
28 distichiasis 9.8
29 meningocele 9.8
30 hemifacial spasm 9.8
31 optic nerve hypoplasia 9.7
32 spondylitis 9.7
33 kallmann syndrome 9.7
34 peritonitis 9.7
35 chiari malformation 9.7
36 communicating hydrocephalus 9.7
37 lipoma 9.7
38 porencephaly 9.7
39 radiculopathy 9.7
40 corpus callosum agenesis 9.7
41 tuberculous meningitis 9.7
42 schizencephaly 9.7
43 sensorineural hearing loss 9.7
44 intracranial hypertension 9.7
45 dandy-walker syndrome 9.7
46 paraplegia 9.7
47 tuberous sclerosis 9.7
48 pachygyria 9.7
49 trichorhinophalangeal syndrome, type i 9.6
50 hemangioma 9.6

Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to Arachnoid Cysts

Symptoms & Phenotypes for Arachnoid Cysts

GenomeRNAi Phenotypes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.23 SLC12A2
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 NRAS
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.23 SLC12A2
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.23 NRAS
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-28 9.23 SLC12A2 NRAS
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-68 9.23 SLC12A2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.23 NRAS

MGI Mouse Phenotypes related to Arachnoid Cysts:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.26 FOXC2 NRAS SLC12A2 COL4A1
2 hearing/vestibular/ear MP:0005377 8.8 FOXC2 SLC12A2 SPAST

Drugs & Therapeutics for Arachnoid Cysts

Drugs for Arachnoid Cysts (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved 2216-51-5 16666

Interventional clinical trials:


id Name Status NCT ID Phase
1 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
2 Treatment for Chronic Spinal Cord Injury: Surgery With Rehabilitation vs Rehabilitation Recruiting NCT02663310

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

Genetic tests related to Arachnoid Cysts:

id Genetic test Affiliating Genes
1 Arachnoid Cyst 29
2 Arachnoid Cysts, Intracranial 29

Anatomical Context for Arachnoid Cysts

MalaCards organs/tissues related to Arachnoid Cysts:

39
Spinal Cord, Brain, Temporal Lobe, Pituitary, Kidney, Testis, Cingulate Cortex

Publications for Arachnoid Cysts

Articles related to Arachnoid Cysts:

(show top 50) (show all 663)
id Title Authors Year
1
Treatment of Middle Cranial Fossa Arachnoid Cysts: A Systematic Review and Meta-Analysis. ( 27319312 )
2016
2
Surgery for intracranial arachnoid cysts in children-a prospective long-term study. ( 27000761 )
2016
3
Septooptic Dysplasia with an Associated Arachnoid Cyst. ( 27891281 )
2016
4
The Acetazolamide Challenge: A Tool for Surgical Decision Making and Predicting Surgical Outcome in Patients with Arachnoid Cysts. ( 27415592 )
2016
5
Sport-related structural brain injury associated with arachnoid cysts: a systematic review and quantitative analysis. ( 27032926 )
2016
6
Prevalence and symptoms of intracranial arachnoid cysts: a population-based study. ( 26860092 )
2016
7
Digital Subtraction Cystography for Detection of Communicating Holes of Spinal Extradural Arachnoid Cysts. ( 26798223 )
2016
8
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
9
Transfrontal Transaqueductal, Transtrigonal, and Suboccipital Infratentorial Supracerebellar Endoscopic Fenestration of Posterior Fossa Arachnoid Cysts: Three Surgical Cases. ( 26968147 )
2016
10
Radiological diagnosis of spinal arachnoid cysts: A pictorial essay. ( 27160059 )
2016
11
Clinical and Radiographical Differences Between Thoracic Idiopathic Spinal Cord Herniation and Spinal Arachnoid Cyst. ( 27926670 )
2016
12
Atypical cause of radiculopathy - Intradural spinal arachnoid cyst. ( 27104760 )
2016
13
Motor Speech Apraxia in a 70-Year-Old Man with Left Dorsolateral Frontal Arachnoid Cyst: A [(18)F]FDG PET-CT Study. ( 28003922 )
2016
14
Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region. ( 26728365 )
2016
15
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27406556 )
2016
16
Pediatric intraventricular arachnoid cysts in the body of lateral ventricle: surgical outcome and its embryologic background. ( 27492334 )
2016
17
Sports participation with arachnoid cysts. ( 26636254 )
2016
18
Letter to the Editor: Are arachnoid cysts and Chiari malformation Type I more common in those with postconcussion syndrome? ( 27611207 )
2016
19
Assessment of endoscopic treatment for quadrigeminal cistern arachnoid cysts: A 7-year experience with 28 cases. ( 26590025 )
2016
20
Transsacrococcygeal approach to ganglion impar block for treatment of chronic coccygodynia after spinal arachnoid cyst removal: A case report. ( 27684866 )
2016
21
Low-Cost Interactive Image-Based Virtual Endoscopy for the Diagnosis and Surgical Planning of Suprasellar Arachnoid Cysts. ( 26732948 )
2016
22
Intramedullary cyst formation after removal of multiple intradural spinal arachnoid cysts: A case report. ( 27512608 )
2016
23
Supraorbital Keyhole Microsurgical Fenestration of Symptomatic Temporal Arachnoid Cysts in Children: Advantages and Limitations. ( 27873293 )
2016
24
Spinal extradural arachnoid cyst: A rare cause of neurogenic bladder. ( 27365974 )
2016
25
Episodic Headache and Arachnoid Cyst Related Subdural Hematoma. ( 27197943 )
2016
26
Comparative analysis of bleeding risk by the location and shape of arachnoid cysts: a finite element model analysis. ( 27718069 )
2016
27
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27379494 )
2016
28
Children With Arachnoid Cysts Who Sustain Blunt Head Trauma: Injury Mechanisms and Outcomes. ( 26728086 )
2016
29
Endoscopic and microsurgical treatment of Sylvian fissure arachnoid cysts - clinical and radiological outcome. ( 25818148 )
2015
30
Clinical characteristics and treatment strategies for idiopathic spinal extradural arachnoid cysts: a single-center experience. ( 25520051 )
2015
31
A symptomatic spinal extradural arachnoid cyst with lumbar disc herniation. ( 25861499 )
2015
32
Neuroendoscopic treatment for hydrocephalus associated to midline arachnoid cysts in a series of nine pediatric patients. ( 26041004 )
2015
33
Endoscopic Treatment of Temporal Arachnoid Cysts in 34 Patients. ( 25968965 )
2015
34
Gradually progressive symptoms of normal pressure hydrocephalus caused by an arachnoid cyst in the fourth ventricle: A case report. ( 26342780 )
2015
35
Bell's palsy in association with a cerebellar arachnoid cyst. ( 25878242 )
2015
36
Clinical and radiological outcomes of surgical treatment for symptomatic arachnoid cysts in adults. ( 26154148 )
2015
37
Posterior fossa arachnoid cysts in adults: Surgical strategy: Case series. ( 25767579 )
2015
38
Chronic Subdural Hematomas Associated with Arachnoid Cysts: Significance in Young Patients with Chronic Subdural Hematomas. ( 26345665 )
2015
39
Exploring predictors of surgery and comparing operative treatment approaches for pediatric intracranial arachnoid cysts: a case series of 83 patients. ( 26067335 )
2015
40
Neuroendoscopy for Intracranial Arachnoid Cysts in Infants: Therapeutic Considerations. ( 26241198 )
2015
41
Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst. ( 26545093 )
2015
42
Shunt placement after cyst fenestration for middle cranial fossa arachnoid cysts in children. ( 26230463 )
2015
43
The effectiveness of microsurgical fenestration for middle fossa arachnoid cysts in children. ( 26424732 )
2015
44
Spinal Extradural Arachnoid Cysts: A Series of 10 Cases. ( 26008955 )
2015
45
Suprasellar Arachnoid Cysts: Toward a New Simple Classification Based on Prognosis and Treatment Modality. ( 26445374 )
2015
46
Multiple Spinal Arachnoid Cysts in a Child. ( 25987363 )
2015
47
Bilateral middle cranial fossa arachnoidal cysts with temporal lobe agenesis associated with astrocytoma: fortuitous finding. ( 25715752 )
2015
48
Surgical Decompression of Arachnoid Cysts Leads to Improved Quality of Life: A Prospective Study. ( 26540351 )
2015
49
Analysis on clinical characteristics of intracranial Arachnoid Cysts in 488 pediatric cases. ( 26770437 )
2015
50
Children With Intracranial Arachnoid Cysts: Classification and Treatment. ( 26554773 )
2015

Variations for Arachnoid Cysts

Copy number variations for Arachnoid Cysts from CNVD:

7 (show all 32)
id CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 41643 10 21822848 21949193 Loss C10orf114 Intracranial arachnoid cysts
2 41644 10 21822848 21949193 Loss C10orf140 Intracranial arachnoid cysts
3 41645 10 21822848 21949193 Loss MLLT10 Intracranial arachnoid cysts
4 57050 11 62557724 62669857 Loss SLC22A24 Intracranial arachnoid cysts
5 63865 12 121446657 121547275 Copy number CLIP1 Intracranial arachnoid cysts
6 63866 12 121446657 121547275 Copy number ZCCHC8 Intracranial arachnoid cysts
7 68816 12 51724073 51844567 Loss CSAD Intracranial arachnoid cysts
8 68817 12 51724073 51844567 Loss IGFBP6 Intracranial arachnoid cysts
9 68818 12 51724073 51844567 Loss SOAT2 Intracranial arachnoid cysts
10 68819 12 51724073 51844567 Loss SPRYD3 Intracranial arachnoid cysts
11 68820 12 51724073 51844567 Loss TENC1 Intracranial arachnoid cysts
12 70825 12 64978487 65093419 Gain ITGB7 Intracranial arachnoid cysts
13 70828 12 64978487 65093419 Gain ZNF740 Intracranial arachnoid cysts
14 86768 14 64978487 65093419 Inversion FUT8 Intracranial arachnoid cysts
15 92669 15 42468491 42598658 Copy number CASC4 Intracranial arachnoid cysts
16 92670 15 42468491 42598658 Copy number CTDSPL2 Intracranial arachnoid cysts
17 101220 16 3431656 3522375 Copy number C16orf90 Intracranial arachnoid cysts
18 101221 16 3431656 3522375 Copy number CLUAP1 Intracranial arachnoid cysts
19 101380 16 3522375 3631656 Loss BTBD12 Intracranial arachnoid cysts
20 101382 16 3522375 3631656 Loss NLRC3 Intracranial arachnoid cysts
21 106726 17 1 10700000 Loss TP53 Intracranial arachnoid cysts
22 112317 17 38560627 38814457 Loss LOC100130581 Intracranial arachnoid cysts
23 112318 17 38560627 38814457 Loss NBR1 Intracranial arachnoid cysts
24 112319 17 38560627 38814457 Loss TMEM106A Intracranial arachnoid cysts
25 124820 19 1205797 1228434 Loss STK11 Intracranial arachnoid cysts
26 125526 19 14246734 14391382 Loss CD97 Intracranial arachnoid cysts
27 125527 19 14246734 14391382 Loss DDX39 Intracranial arachnoid cysts
28 227152 7 6498207 6600621 Deletion C7orf26 Intracranial arachnoid cysts
29 227153 7 6498207 6600621 Deletion GRID2IP Intracranial arachnoid cysts
30 227154 7 6498207 6600621 Deletion ZDHHC4 Intracranial arachnoid cysts
31 233699 8 12700000 19000000 Loss N33 Intracranial arachnoid cysts
32 239856 8 42175206 42281148 Copy number PLAT Intracranial arachnoid cysts

Expression for Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for Arachnoid Cysts

Pathways related to Arachnoid Cysts according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.62 COL4A1 NRAS

GO Terms for Arachnoid Cysts

Biological processes related to Arachnoid Cysts according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 branching involved in blood vessel morphogenesis GO:0001569 8.62 COL4A1 FOXC2

Sources for Arachnoid Cysts

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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