MCID: ARC007
MIFTS: 61

Arachnoid Cysts malady

Rare diseases, Neuronal diseases, Endocrine diseases, Fetal diseases categories
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Summaries for Arachnoid Cysts

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Sources:
43NIH Rare Diseases, 44NINDS, 65Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Arachnoid cysts are sacs filled with cerebrospinal fluid (csf) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. arachnoid cysts can be primary or secondary. primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. secondary arachnoid cysts are less common and result from head injuries, meningitis, tumors, or as a complication of brain surgery. signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. although many affected individuals develop symptoms in the first year of life, some never develop symptoms. whether and how to treat the condition depends on the location and size of the cyst; when treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the csf. last updated: 7/11/2013

MalaCards: Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to precocious puberty and hypopituitarism. An important gene associated with Arachnoid Cysts is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)), and among its related pathways are Nuclear signaling by ERBB4 and Phospholipase-C Pathway. The compounds ammonium and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

NINDS:44 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.

Wikipedia:65 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Description from OMIM:47 182990,207790

Aliases & Classifications for Arachnoid Cysts

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43NIH Rare Diseases, 22GTR, 44NINDS, 49Orphanet, 47OMIM, 62UMLS, 36MESH via Orphanet, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

49
arachnoid cyst:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

arachnoid cysts 43 44 62
intracranial arachnoid cysts 43 22
arachnoid cyst 49 47
arachnoid cysts, intracranial 43


External Ids:

MESH via Orphanet36 D016080
ICD10 via Orphanet26 G93.0
SNOMED-CT via Orphanet59 33595009
UMLS via Orphanet63 C0078981

Related Diseases for Arachnoid Cysts

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to arachnoid cysts

Symptoms for Arachnoid Cysts

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47OMIM
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Symptoms by clinical synopsis from OMIM:

182990

Clinical features from OMIM:

182990,207790

Drugs & Therapeutics for Arachnoid Cysts

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Arachnoid Cysts

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

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22GTR
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Genetic tests related to Arachnoid Cysts:

id Genetic test Affiliating Genes
1 Arachnoid Cysts, Intracranial22

Anatomical Context for Arachnoid Cysts

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33MalaCards
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MalaCards organs/tissues related to Arachnoid Cysts:

33
Spinal cord, Brain, Temporal lobe, Pituitary, Testis, Kidney, Cortex, Cerebellum, Bone, Cingulate cortex

Animal Models for Arachnoid Cysts or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Arachnoid Cysts:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2SLC12A2, FOXC2, PGR, GNRH1
2MP:00053797.8GNRH1, PGR, GH1, SLC12A2
3MP:00036317.4SPAST, GNRH1, FOXC2, GH1, COL4A1, SLC12A2
4MP:00053897.3SLC12A2, COL4A1, GH1, PGR, GNRH1, SPAST

Publications for Arachnoid Cysts

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52PubMed
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Articles related to Arachnoid Cysts:

(show top 50)    (show all 572)
idTitleAuthorsYear
1
Surgical management of intracranial arachnoid cysts: clinical and radiological outcome. (23546896)
2013
2
Cluster headache and arachnoid cyst. (23419954)
2013
3
Arachnoid cysts in tuberous sclerosis complex. (24325802)
2013
4
Bilateral retrocerebellar arachnoid cysts exerting mass effect and associated with cerebellar tonsillar ectopia in an otherwise healthy adult. (23615422)
2013
5
Endonasal management of sellar arachnoid cysts: simple cyst obliteration technique. (22283187)
2012
6
Should we resect all multiple intraspinal extradural arachnoid cysts? A case report. (22843467)
2012
7
Surgical management strategies of intracranial arachnoid cysts: a single institution experience of 75 cases. (23015336)
2012
8
CT cisternography in intracranial symptomatic arachnoid cysts: classification and treatment. (22520095)
2012
9
A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)
2012
10
Transient paraplegia after accidental insertion of an epidural catheter into an arachnoid cyst. (21897183)
2011
11
Endoscopic treatment of suprasellar arachnoid cysts in children. (21721882)
2011
12
Arachnoid cysts of the fourth ventricle - short illustrated review. (19387540)
2010
13
Spinal cord compression caused by idiopathic intradural arachnoid cysts of the spine: review of the literature and illustrated case. (19763637)
2010
14
Guidelines for the management of obstructive hydrocephalus from suprasellar-prepontine arachnoid cysts using endoscopic third ventriculocystocisternostomy. (20688773)
2010
15
Spinal extradural arachnoid cysts in lymphedema-distichiasis syndrome. (20535019)
2010
16
CSF overdrainage in shunted intracranial arachnoid cysts: a series and review. (19452154)
2009
17
Multiple extradural spinal arachnoid cysts: a case report and review of the literature. (19829999)
2009
18
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. (18400590)
2008
19
A case with giant arachnoid cysts manifested as migraine. (19116706)
2008
20
Intrasacral extradural arachnoid cysts. (18497497)
2008
21
Asymptomatic massive subdural hematoma in a patient with bitemporal agenesis and bilateral temporal arachnoid cysts. (18364667)
2008
22
Regression of syringomyelia and tonsillar herniation after posterior fossa arachnoid cyst excision. Case report and literature review. (17622461)
2007
23
Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. Case report and review of the literature. (16302620)
2005
24
Cystoventricular shunting of intracranial arachnoid cysts. (14734867)
2003
25
Do quiescent arachnoid cysts alter CNS functional organization?: A fMRI and morphometric study. (12499486)
2002
26
Apparent paradoxical vault changes with middle cranial fossa arachnoid cysts--implication for aetiology. (11895303)
2001
27
Children with bilateral temporal arachnoid cysts may have glutaric aciduria type 1 (GAT1); operation without knowing that may be harmful. (11086812)
2000
28
A case report of caudal regression syndrome associated with an intraspinal arachnoid cyst. (10705931)
1999
29
Anterior thoracic intradural arachnoid cysts. Case report and review of the literature. (17031914)
1999
30
Arachnoid cysts associated with post-traumatic and spontaneous rupture into the subdural space. (9690007)
1997
31
Surgical options in the treatment of interhemispheric arachnoid cysts. (8781589)
1996
32
Bilateral arachnoid cysts, seizures and severe encephalopathy: case report. (8208351)
1994
33
Nontraumatic intradiploic arachnoid cysts--report of five cases. (1282679)
1992
34
Endoscopic treatment of suprasellar arachnoid cysts. (1481755)
1992
35
Do arachnoid cysts grow? A retrospective CT volumetric study. (1922751)
1991
36
Intermittent downbeat nystagmus secondary to vermian arachnoid cyst with associated obstructive hydrocephalus. (1838553)
1991
37
A variant of the syndrome of spinal arachnoid cysts with multiple congenital defects. (2021437)
1991
38
Arachnoiditis ossificans with arachnoid cyst after cranial tuberculous meningitis. (2320252)
1990
39
Middle fossa arachnoid cysts. (2583835)
1989
40
MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. (2505512)
1989
41
Magnetic resonance imaging of arachnoid cysts. (2598110)
1989
42
Arachnoid cysts of the sylvian fissure. Evidence of fluid secretion. (6231356)
1984
43
Arachnoid cysts of the posterior fossa. Report of three cases. (6858736)
1983
44
Spinal intradural arachnoid cysts. (7110485)
1982
45
Multiple spinal arachnoid cysts: the role of oily contrast medium. (6264636)
1981
46
Arachnoid cysts in children: ultrastructural findings. (6939278)
1981
47
Posterior fossa arachnoid cysts. (501222)
1979
48
The dysraphic state of the posterior fossa. Clinical review of the Dandy-Walker syndrome and the so-called arachnoid cysts. (536750)
1979
49
Infratentorial arachnoid cysts. (4542573)
1973
50
Congenital spinal arachnoid cysts; report of two cases and review of the literature. (5418175)
1970

Variations for Arachnoid Cysts

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Expression for genes affiliated with Arachnoid Cysts

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for genes affiliated with Arachnoid Cysts

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50PathCards, 55Reactome, 53QIAGEN
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Pathways related to Arachnoid Cysts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5GH1, PGR
2
Show member pathways
9.0COL4A1, GH1, GNRH1

Compounds for genes affiliated with Arachnoid Cysts

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45Novoseek, 51PharmGKB, 11DrugBank, 29IUPHAR, 61Tocris Bioscience, 24HMDB
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Compounds related to Arachnoid Cysts according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1ammonium4510.0GH1, MIP
2anastrozole45 51 1111.9GH1, PGR
3triphenylethylene459.9DYT10, PGR
4gestrinone459.8PGR, GNRH1
5adenosine 3,5-cyclic monophosphorothioate459.8GNRH1, DYT10
6naltrexone45 29 51 1112.8GNRH1, GH1
7estradiol benzoate459.8GNRH1, PGR
8metoclopramide45 51 1111.7GNRH1, GH1
91-(5-isoquinolinylsulfonyl)-2-methylpiperazine459.7GNRH1, DYT10
10goserelin45 29 1111.7GNRH1, PGR
11cabergoline45 29 1111.7GNRH1, GH1
12nilutamide45 61 29 1112.7GNRH1, PGR
13allopregnanolone459.7PGR, GNRH1
14buserelin45 29 1111.7PGR, GNRH1
15trifluoperazine45 29 51 1112.7GH1, DYT10
16toremifene45 1110.7PGR, GNRH1
17tibolone459.7PGR, GNRH1
18danazol45 24 1111.7GNRH1, PGR
19cyproteroneacetate459.7PGR, GNRH1
20spironolactone45 61 29 51 1113.6GNRH1, PGR
21flutamide45 61 1111.6PGR, GNRH1
22steroidal459.6PGR, GNRH1
23pertussis459.6GH1, DYT10
24bromocriptine45 29 1111.5GNRH1, GH1
25pkcs459.5DYT10, GNRH1
26diethylstilbestrol45 29 1111.4GNRH1, PGR
27leuprolide acetate459.3GH1, PGR, GNRH1
28clomiphene citrate459.3GH1, PGR, GNRH1
29progestins459.3GH1, PGR, GNRH1
30raloxifene45 51 29 1112.3GNRH1, PGR, GH1
31estrone45 29 24 1112.3GH1, PGR, GNRH1
32verapamil45 29 51 24 1113.3DYT10, GH1, GNRH1
33naloxone45 29 51 1112.3GNRH1, GH1
34nifedipine45 29 51 1112.3DYT10, GH1, GNRH1
35dihydrotestosterone45 29 24 1112.3GNRH1, PGR, GH1
36thyroxine45 2410.3GH1, PGR, GNRH1
37dmso459.3GNRH1, PGR, GH1
38ribonucleic acid459.2GH1, PGR, GNRH1
39dehydroepiandrosterone sulfate459.1GH1, GNRH1
40actinomycin d459.1DYT10, GH1, GNRH1
41vegf459.0DYT10, GH1, MIP, PGR
42dexamethasone45 51 29 1111.9GNRH1, PGR, MIP, GH1
43estradiol45 24 1110.9GH1, PGR, GNRH1
44gaba458.9SLC12A2, PGR, GNRH1
45gnrh458.8GNRH1, PGR, GH1, DYT10
46tamoxifen45 51 29 1111.8DYT10, GH1, PGR, GNRH1
47adenylate458.8DYT10, GH1, PGR, GNRH1
48forskolin45 51 1110.7SLC12A2, DYT10, GH1
49retinoic acid45 249.6GNRH1, PGR, GH1, DYT10
50glutamate458.5GNRH1, MIP, DYT10, SLC12A2

GO Terms for genes affiliated with Arachnoid Cysts

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16Gene Ontology
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Biological processes related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patterning of blood vesselsGO:0015699.7COL4A1, FOXC2

Molecular functions related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4GH1, GNRH1

Products for genes affiliated with Arachnoid Cysts

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Sources for Arachnoid Cysts

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet