Arachnoid Cysts malady

NIH Rare Diseases: Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.  Primary arachnoid cysts are present at birth and are the result of developmental abnormalities in the brain and spinal cord that arise during the early weeks of gestation. Secondary arachnoid cysts are not as common as primary cysts and develop as a result of head injury, meningitis, or tumors, or as a complication of brain surgery. Males are four times more likely to have arachnoid cysts than females.³⁰

MalaCards: Arachnoid Cysts, also known as arachnoid cysts, intracranial, is related to arachnoiditis and endolymphatic hydrops. An important gene associated with Arachnoid Cysts is C19orf33 (chromosome 19 open reading frame 33). The compounds gnrh and adenosine 3,5-cyclic monophosphorothioate have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and pituitary, and related mouse phenotype reproductive system.

NINDS: Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.³¹

Wikipedia: Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop...⁴⁴ more...

arachnoid cysts 30 31 43 arachnoid cysts, intracranial 30

intracranial arachnoid cysts 30

Diseases related to arachnoid cysts by text searches and GeneDecks gene sharing:

(show all 41)

id	Related Disease	Score	Top Affiliating Genes
1	arachnoiditis	25.9	MIP, FOXC2, SACS, ADCK2, EPB42, PGR
2	endolymphatic hydrops	13.1	MIP, CRLF1
3	hypothalamic hamartomas	12.9	GNRH1, SLC12A2
4	catamenial pneumothorax	12.8	PGR, GNRH1
5	trigonitis	12.7	DYT10, PGR
6	hypothalamic disease	12.5	GNRH1, GH1
7	robinow syndrome	12.5	GNRH1, GH1
8	gonadal disease	12.5	GNRH1, GH1
9	pituitary apoplexy	12.5	GNRH1, GH1
10	aromatase deficiency	12.5	GH1, GNRH1
11	pituitary gland disease	12.4	GH1, GNRH1
12	syringomyelia	12.4	RICTOR, CRLF1, GH1
13	gonadotropin deficiency	12.4	GNRH1, GH1
14	thyroid hormone resistance syndrome	12.3	GH1, GNRH1
15	impotence	12.2	DYT10, GNRH1
16	fragile x-associated primary ovarian insufficiency	12.1	GNRH1, GH1
17	hyperprolactinemia	12.0	GNRH1, GH1, PGR
18	adenomyosis	11.9	GNRH1, PGR, GH1
19	noma	11.8	PGR, SLC12A2, DYT10, GNRH1
20	cushing's syndrome	11.7	GNRH1, GH1, PGR
21	polycystic ovary syndrome	11.7	FOXC2, GH1, GNRH1, PGR
22	pituitary tumor	11.4	DYT10, GNRH1, GH1, PGR
23	insulin resistance	11.2	MIP, DYT10, GH1, GNRH1, FOXC2
24	primary hyperoxaluria	11.1	GH1, GNRH1, FOXC2, SLC12A2, DYT10
25	choriocarcinoma	11.1	PGR, GH1, DYT10, GNRH1
26	blindness	11.0	GNRH1, DYT10, GH1, MIP, PGR
27	osteoporosis	11.0	PGR, GH1, GNRH1, MIP
28	peritonitis	11.0	MIP, GNRH1, GH1, DYT10, PGR
29	obesity	10.5	MIP, FOXC2, GNRH1, GH1, DYT10, PGR
30	cerebritis	10.3	DYT10, MIP, GH1, SPAST, SLC12A2, PGR
31	tibia absent polydactyly arachnoid cyst	8.7
32	spinal intradural arachnoid cysts	8.4
33	lymphedema	7.5
34	chudley-mccullough syndrome	7.5
35	choreoathetosis	6.6
36	intracranial cysts	6.6
37	meningioma	6.6
38	paraplegia	6.6
39	paroxysmal kinesigenic choreoathetosis	6.6
40	spastic paraplegia	6.6
41	spasticity	6.6

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to arachnoid cysts:

²²

MGI Mouse Phenotypes related to arachnoid cysts:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	reproductive system phenotype	MP:0005389	7.0	MAP3K9, GNRH1, GH1, SPAST, SLC12A2, PGR

Articles related to arachnoid cysts:

id	Title	Authors	Year	Affiliating Genes
1	Spinal extradural arachnoid cysts in lymphedema-disti chiasis syndrome. (20535019)	SA!nchez-Carpintero R.... PatiA+o-GarcA-a A.	2010	FOXC2
2	Increased NKCC1 expression in arachnoid cysts support s secretory basis for cyst formation. (20471979)	Helland C.A.... Wester K.	2010	SLC12A2
3	Spinal extradural arachnoid cysts associated with distichiasis and lymphedema. (17366583)	Yabuki S.... Ikegawa S.	2007	FOXC2
4	Causes of arachnoid cyst development and expansion. (17608347)	Basaldella L.... Longatti P.	2007	MIP
5	A new SPG4 mutation in a variant form of spastic paraplegia with congenital arachnoid cysts. (15159500)	Orlacchio A.... Kawarai T.	2004	SPAST
6	Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst. (10834520)	Adan L.... Brauner R.	2000	GNRH1
7	The endocrine spectrum of arachnoid cysts in childhood. (10702732)	Mohn A.... DAPrr H.G.	1999	GH1
8	Paroxysmal kinesigenic choreoathetosis associated with frontotemporal arachnoid cyst--case report. (10193153)	Urasaki E.... Yokota A.	1999	DYT10
9	Progesterone receptors in arachnoid cysts. An immunocytochemical study in 2 cases. (9202776)	Go K.G.... Verhagen A.	1997	PGR
10	The presence of progesterone receptors in arachnoid granulations and in the lining of arachnoid cysts: its relevance to expression of progesterone receptors in meningiomas. (7786426)	Verhagen A.... Vaalburg W.	1995	PGR

Genes related to arachnoid cysts according to GeneCards:

(show all 16)

id	Symbol	Description	Score	GeneCards Section Context
1	C19orf33	chromosome 19 open reading frame 33	11.0
2	FOXC2	forkhead box C2 (MFH-1, mesenchyme forkhead 1)	11.0	Publications
3	ADCK2	aarF domain containing kinase 2	11.0
4	CRLF1	cytokine receptor-like factor 1	11.0
5	EPB42	erythrocyte membrane protein band 4.2	11.0
6	PSMD8	proteasome (prosome, macropain) 26S subunit, non-ATPase, 8	11.0
7	MIP	major intrinsic protein of lens fiber	11.0	Publications
8	SLC12A2	solute carrier family 12 (sodium/potassium/chloride transporters), member 2	11.0	Publications
9	SPAST	spastin	11.0	Publications
10	MAP3K9	mitogen-activated protein kinase kinase kinase 9	11.0
11	SACS	spastic ataxia of Charlevoix-Saguenay (sacsin)	11.0
12	RICTOR	RPTOR independent companion of MTOR, complex 2	11.0
13	GNRH1	gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)	11.0	Publications
14	PGR	progesterone receptor	11.0	Publications
15	GH1	growth hormone 1	11.0	Publications
16	DYT10	dystonia 10	11.0	Publications

Compounds related to arachnoid cysts according to GeneDecks:

(show all 20)

id	Compound	Score	Top Affiliating Genes
1	gnrh32	9.9	GH1
2	adenosine 3,5-cyclic monophosphorothioate32	9.7	DYT10, GNRH1
3	gestrinone32	9.7	GNRH1, PGR
4	triphenylethylene32	9.6	DYT10, PGR
5	1-(5-isoquinolinylsulfonyl)-2-methylpiperazine32	9.6	GNRH1, DYT10
6	nilutamide42 32 9 9	12.6	PGR, GNRH1
7	estradiol benzoate32	9.6	PGR, GNRH1
8	goserelin32 9 9	11.5	GNRH1, PGR
9	allopregnanolone32	9.4	PGR, GNRH1
10	buserelin32 9 9	11.3	PGR, GNRH1
11	leuprolide acetate32	8.8	GH1, PGR, GNRH1
12	clomiphene citrate32	8.8	GNRH1, PGR, GH1
13	metoclopramide32 9 9	10.8	GNRH1, GH1
14	raloxifene32 9 9	10.8	GNRH1, PGR, GH1
15	progestins32	8.8	PGR, GH1, GNRH1
16	verapamil32 34 9 18 9	12.7	DYT10, GH1, GNRH1
17	estrone32 9 18 9	11.7	PGR, GNRH1, GH1
18	dihydrotestosterone32 9 18 9	11.5	GNRH1, PGR, GH1
19	nifedipine32 9 9	10.5	GH1, DYT10, GNRH1
20	tamoxifen32 34 9 9	11.2	DYT10, PGR, GNRH1, GH1