MCID: ARC007
MIFTS: 45

Arachnoid Cysts malady

Neuronal diseases, Endocrine diseases, Fetal diseases categories

Summaries for Arachnoid Cysts

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42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Arachnoid cysts are sacs filled with cerebrospinal fluid (csf) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. arachnoid cysts can be primary or secondary. primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. secondary arachnoid cysts are less common and result from head injuries, meningitis, tumors, or as a complication of brain surgery. signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. although many affected individuals develop symptoms in the first year of life, some never develop symptoms. whether and how to treat the condition depends on the location and size of the cyst; when treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the csf. last updated: 7/11/2013

MalaCards: Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to arachnoiditis and syringomyelia. An important gene associated with Arachnoid Cysts is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)). The compounds gestrinone and estradiol benzoate have been mentioned in the context of this disorder. Affiliated tissues include spinal cord and brain, and related mouse phenotypes are nervous system and reproductive system.

NINDS:43 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.

Wikipedia:63 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Description from OMIM:46 182990,207790

Aliases & Classifications for Arachnoid Cysts

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42NIH Rare Diseases, 22GTR, 43NINDS, 48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
arachnoid cyst:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Childhood; Age of death: Normal


Aliases & Descriptions:

arachnoid cysts 42 43 60
intracranial arachnoid cysts 42 22
arachnoid cyst 48 46
arachnoid cysts, intracranial 42


External Ids:

MESH via Orphanet35 D016080
ICD10 via Orphanet26 G93.0
SNOMED-CT via Orphanet57 33595009
UMLS via Orphanet61 C0078981

Related Diseases for Arachnoid Cysts

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to arachnoid cysts

Clinical Features for Arachnoid Cysts

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46OMIM
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Clinical features from OMIM:

182990,207790

Clinical synopsis from OMIM:

182990

Drugs & Therapeutics for Arachnoid Cysts

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Search NIH Clinical Center for Arachnoid Cysts

Search CenterWatch for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

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22GTR
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Genetic tests related to Arachnoid Cysts:

id Genetic test Affiliating Genes
1 Arachnoid Cysts, Intracranial22

Anatomical Context for Arachnoid Cysts

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32MalaCards
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MalaCards organs/tissues related to Arachnoid Cysts:

32
Spinal cord, Brain

Animal Models for Arachnoid Cysts or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Arachnoid Cysts:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036317.8COL4A1, GNRH1, FOXC2, CRLF1, GH1, MAP3K9
2MP:00053896.8COL4A1, GNRH1, GH1, MAP3K9, RICTOR, PGR

Publications for Arachnoid Cysts

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Genetic Variations for Arachnoid Cysts

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Expression for genes affiliated with Arachnoid Cysts

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arachnoid Cysts

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Pathways for genes affiliated with Arachnoid Cysts

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Compounds for genes affiliated with Arachnoid Cysts

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Arachnoid Cysts according to GeneCards/GeneDecks:

(show all 29)
idCompoundScoreTop Affiliating Genes
1gestrinone4410.2PGR, GNRH1
2estradiol benzoate4410.2PGR, GNRH1
3goserelin44 28 1112.2PGR, GNRH1
4allopregnanolone4410.1GNRH1, PGR
5buserelin44 28 1112.1PGR, GNRH1
6anastrozole44 1111.1PGR, GH1
7metoclopramide44 1111.1GH1, GNRH1
8adenosine 3,5-cyclic monophosphorothioate4410.0GNRH1, DYT10
9toremifene44 1111.0PGR, GNRH1
101-(5-isoquinolinylsulfonyl)-2-methylpiperazine4410.0DYT10, GNRH1
11triphenylethylene4410.0PGR, DYT10
12nilutamide44 59 28 1113.0PGR, SACS, GNRH1
13naltrexone44 49 28 1113.0GNRH1, GH1
14flutamide44 59 1111.9PGR, SACS, GNRH1
15leuprolide acetate449.9PGR, GH1, GNRH1
16clomiphene citrate449.9GNRH1, GH1, PGR
17progestins449.9GNRH1, GH1, PGR
18raloxifene44 28 49 1112.9PGR, GH1, GNRH1
19tibolone449.9PGR, GNRH1
20cyproteroneacetate449.9PGR, GNRH1
21estrone44 28 11 2412.9GNRH1, GH1, PGR
22danazol44 11 2411.8PGR
23cabergoline28 44 1111.8GH1, GNRH1
24dihydrotestosterone44 28 11 2412.7GNRH1, GH1, PGR
25thyroxine44 2410.7PGR, GH1, GNRH1
26verapamil44 49 28 11 2413.6GNRH1, DYT10, GH1
27nifedipine44 49 28 1112.6GH1, DYT10, GNRH1
28gnrh449.4PGR, GH1, DYT10, GNRH1
29tamoxifen44 49 28 1112.3PGR, GH1, DYT10, GNRH1

GO Terms for genes affiliated with Arachnoid Cysts

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16Gene Ontology
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Biological processes related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of tyrosine phosphorylation of Stat3 proteinGO:0425179.9GH1, CRLF1

Products for genes affiliated with Arachnoid Cysts

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arachnoid Cysts

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet