MCID: ARC007
MIFTS: 62

Arachnoid Cysts malady

Rare diseases, Neuronal diseases, Endocrine diseases, Fetal diseases categories

Summaries for Arachnoid Cysts

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NIH Rare Diseases:42 Arachnoid cysts are sacs filled with cerebrospinal fluid (csf) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. arachnoid cysts can be primary or secondary. primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. secondary arachnoid cysts are less common and result from head injuries, meningitis, tumors, or as a complication of brain surgery. signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. although many affected individuals develop symptoms in the first year of life, some never develop symptoms. whether and how to treat the condition depends on the location and size of the cyst; when treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the csf. last updated: 7/11/2013

MalaCards based summary: Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to precocious puberty and hypopituitarism, and has symptoms including autosomal dominant inheritance, abnormality of the vertebral column and paraplegia. An important gene associated with Arachnoid Cysts is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)), and among its related pathways are Nuclear signaling by ERBB4 and Phospholipase-C Pathway. The compounds ammonium and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

NINDS:43 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.

Wikipedia:64 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Descriptions from OMIM:46 182990,207790

Aliases & Classifications for Arachnoid Cysts

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Sources:
42NIH Rare Diseases, 23GTR, 43NINDS, 48Orphanet, 46OMIM, 61UMLS, 27ICD10 via Orphanet, 62UMLS via Orphanet, 35MESH via Orphanet
See all sources

Arachnoid Cysts, Aliases & Descriptions:

Name: Arachnoid Cysts 42 43 61
Intracranial Arachnoid Cysts 42 23 61
 
Arachnoid Cyst 48 46
Arachnoid Cysts, Intracranial 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
arachnoid cyst:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Childhood; Age of death: Normal


External Ids:

ICD10 via Orphanet27 G93.0
UMLS via Orphanet62 C0078981
MESH via Orphanet35 D016080

Related Diseases for Arachnoid Cysts

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Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to arachnoid cysts

Symptoms for Arachnoid Cysts

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Symptoms by clinical synopsis from OMIM:

182990

Clinical features from OMIM:

182990,207790

HPO human phenotypes related to Arachnoid Cysts:

(show all 8)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the vertebral column HP:0000925
3 paraplegia HP:0010550
4 autosomal recessive inheritance HP:0000007
5 microcephaly HP:0000252
6 macrocephaly HP:0000256
7 intellectual disability HP:0001249
8 arachnoid cyst HP:0100702

Drugs & Therapeutics for Arachnoid Cysts

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Drug clinical trials:

Search ClinicalTrials for Arachnoid Cysts

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

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Genetic tests related to Arachnoid Cysts:

id Genetic test Affiliating Genes
1 Arachnoid Cysts, Intracranial23

Anatomical Context for Arachnoid Cysts

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MalaCards organs/tissues related to Arachnoid Cysts:

32
Spinal cord, Brain, Temporal lobe, Pituitary, Bone, Cortex, Cerebellum, Kidney, Testis, Cingulate cortex

Animal Models for Arachnoid Cysts or affiliated genes

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MGI Mouse Phenotypes related to Arachnoid Cysts:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2SLC12A2, FOXC2, PGR, GNRH1
2MP:00053797.8GNRH1, PGR, GH1, SLC12A2
3MP:00036317.4SPAST, GNRH1, FOXC2, GH1, COL4A1, SLC12A2
4MP:00053897.3SLC12A2, COL4A1, GH1, PGR, GNRH1, SPAST

Publications for Arachnoid Cysts

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Articles related to Arachnoid Cysts:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Surgical management of intracranial arachnoid cysts: clinical and radiological outcome. (23546896)
2013
2
Cluster headache and arachnoid cyst. (23419954)
2013
3
Arachnoid cysts in tuberous sclerosis complex. (24325802)
2013
4
Bilateral retrocerebellar arachnoid cysts exerting mass effect and associated with cerebellar tonsillar ectopia in an otherwise healthy adult. (23615422)
2013
5
Endonasal management of sellar arachnoid cysts: simple cyst obliteration technique. (22283187)
2012
6
Should we resect all multiple intraspinal extradural arachnoid cysts? A case report. (22843467)
2012
7
Surgical management strategies of intracranial arachnoid cysts: a single institution experience of 75 cases. (23015336)
2012
8
CT cisternography in intracranial symptomatic arachnoid cysts: classification and treatment. (22520095)
2012
9
A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)
2012
10
Transient paraplegia after accidental insertion of an epidural catheter into an arachnoid cyst. (21897183)
2011
11
Endoscopic treatment of suprasellar arachnoid cysts in children. (21721882)
2011
12
Arachnoid cysts of the fourth ventricle - short illustrated review. (19387540)
2010
13
Spinal cord compression caused by idiopathic intradural arachnoid cysts of the spine: review of the literature and illustrated case. (19763637)
2010
14
Guidelines for the management of obstructive hydrocephalus from suprasellar-prepontine arachnoid cysts using endoscopic third ventriculocystocisternostomy. (20688773)
2010
15
Spinal extradural arachnoid cysts in lymphedema-distichiasis syndrome. (20535019)
2010
16
Multiple extradural spinal arachnoid cysts: a case report and review of the literature. (19829999)
2009
17
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. (18400590)
2008
18
A case with giant arachnoid cysts manifested as migraine. (19116706)
2008
19
Intrasacral extradural arachnoid cysts. (18497497)
2008
20
Asymptomatic massive subdural hematoma in a patient with bitemporal agenesis and bilateral temporal arachnoid cysts. (18364667)
2008
21
Regression of syringomyelia and tonsillar herniation after posterior fossa arachnoid cyst excision. Case report and literature review. (17622461)
2007
22
Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. Case report and review of the literature. (16302620)
2005
23
Cystoventricular shunting of intracranial arachnoid cysts. (14734867)
2003
24
Do quiescent arachnoid cysts alter CNS functional organization?: A fMRI and morphometric study. (12499486)
2002
25
Apparent paradoxical vault changes with middle cranial fossa arachnoid cysts--implication for aetiology. (11895303)
2001
26
Children with bilateral temporal arachnoid cysts may have glutaric aciduria type 1 (GAT1); operation without knowing that may be harmful. (11086812)
2000
27
A case report of caudal regression syndrome associated with an intraspinal arachnoid cyst. (10705931)
1999
28
Anterior thoracic intradural arachnoid cysts. Case report and review of the literature. (17031914)
1999
29
Arachnoid cysts associated with post-traumatic and spontaneous rupture into the subdural space. (9690007)
1997
30
Surgical options in the treatment of interhemispheric arachnoid cysts. (8781589)
1996
31
Bilateral arachnoid cysts, seizures and severe encephalopathy: case report. (8208351)
1994
32
Nontraumatic intradiploic arachnoid cysts--report of five cases. (1282679)
1992
33
Endoscopic treatment of suprasellar arachnoid cysts. (1481755)
1992
34
Do arachnoid cysts grow? A retrospective CT volumetric study. (1922751)
1991
35
Intermittent downbeat nystagmus secondary to vermian arachnoid cyst with associated obstructive hydrocephalus. (1838553)
1991
36
A variant of the syndrome of spinal arachnoid cysts with multiple congenital defects. (2021437)
1991
37
Arachnoiditis ossificans with arachnoid cyst after cranial tuberculous meningitis. (2320252)
1990
38
The value of MRI in the study of spinal extradural arachnoid cysts. (2346931)
1990
39
Middle fossa arachnoid cysts. (2583835)
1989
40
MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. (2505512)
1989
41
Magnetic resonance imaging of arachnoid cysts. (2598110)
1989
42
Otolaryngologic manifestations of posterior fossa arachnoid cysts. (3999903)
1985
43
Arachnoid cysts of the sylvian fissure. Evidence of fluid secretion. (6231356)
1984
44
Arachnoid cysts of the posterior fossa. Report of three cases. (6858736)
1983
45
Spinal intradural arachnoid cysts. (7110485)
1982
46
Multiple spinal arachnoid cysts: the role of oily contrast medium. (6264636)
1981
47
Arachnoid cysts in children: ultrastructural findings. (6939278)
1981
48
Posterior fossa arachnoid cysts. (501222)
1979
49
Infratentorial arachnoid cysts. (4542573)
1973
50
Congenital spinal arachnoid cysts; report of two cases and review of the literature. (5418175)
1970

Variations for Arachnoid Cysts

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Expression for genes affiliated with Arachnoid Cysts

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Expression patterns in normal tissues for genes affiliated with Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for genes affiliated with Arachnoid Cysts

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Pathways related to Arachnoid Cysts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5GH1, PGR
2
Show member pathways
9.0COL4A1, GH1, GNRH1

Compounds for genes affiliated with Arachnoid Cysts

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Compounds related to Arachnoid Cysts according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1ammonium4410.0GH1, MIP
2anastrozole44 50 1211.9GH1, PGR
3triphenylethylene449.9DYT10, PGR
4gestrinone449.8PGR, GNRH1
5adenosine 3,5-cyclic monophosphorothioate449.8GNRH1, DYT10
6naltrexone44 29 50 1212.8GNRH1, GH1
7estradiol benzoate449.8GNRH1, PGR
8metoclopramide44 50 1211.7GNRH1, GH1
91-(5-isoquinolinylsulfonyl)-2-methylpiperazine449.7GNRH1, DYT10
10goserelin44 29 1211.7GNRH1, PGR
11cabergoline44 29 1211.7GNRH1, GH1
12nilutamide44 60 29 1212.7GNRH1, PGR
13allopregnanolone449.7PGR, GNRH1
14buserelin44 29 1211.7PGR, GNRH1
15trifluoperazine44 29 50 1212.7GH1, DYT10
16toremifene44 1210.7PGR, GNRH1
17tibolone449.7PGR, GNRH1
18danazol44 25 1211.7GNRH1, PGR
19cyproteroneacetate449.7PGR, GNRH1
20spironolactone44 60 29 50 1213.6GNRH1, PGR
21flutamide44 60 1211.6PGR, GNRH1
22steroidal449.6PGR, GNRH1
23pertussis449.6GH1, DYT10
24bromocriptine44 29 1211.5GNRH1, GH1
25pkcs449.5DYT10, GNRH1
26diethylstilbestrol44 29 1211.4GNRH1, PGR
27leuprolide acetate449.3GH1, PGR, GNRH1
28clomiphene citrate449.3GH1, PGR, GNRH1
29progestins449.3GH1, PGR, GNRH1
30raloxifene44 50 29 1212.3GNRH1, PGR, GH1
31estrone44 29 25 1212.3GH1, PGR, GNRH1
32verapamil44 29 50 25 1213.3DYT10, GH1, GNRH1
33naloxone44 29 50 1212.3GNRH1, GH1
34nifedipine44 29 50 1212.3DYT10, GH1, GNRH1
35dihydrotestosterone44 29 25 1212.3GNRH1, PGR, GH1
36thyroxine44 2510.3GH1, PGR, GNRH1
37dmso449.3GNRH1, PGR, GH1
38ribonucleic acid449.2GH1, PGR, GNRH1
39dehydroepiandrosterone sulfate449.1GH1, GNRH1
40actinomycin d449.1DYT10, GH1, GNRH1
41vegf449.0DYT10, GH1, MIP, PGR
42dexamethasone44 50 29 1211.9GNRH1, PGR, MIP, GH1
43estradiol44 25 1210.9GH1, PGR, GNRH1
44gaba448.9SLC12A2, PGR, GNRH1
45gnrh448.8GNRH1, PGR, GH1, DYT10
46tamoxifen44 50 29 1211.8DYT10, GH1, PGR, GNRH1
47adenylate448.8DYT10, GH1, PGR, GNRH1
48forskolin44 50 1210.7SLC12A2, DYT10, GH1
49retinoic acid44 259.6GNRH1, PGR, GH1, DYT10
50glutamate448.5GNRH1, MIP, DYT10, SLC12A2

GO Terms for genes affiliated with Arachnoid Cysts

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Biological processes related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patterning of blood vesselsGO:0015699.7COL4A1, FOXC2

Molecular functions related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4GH1, GNRH1

Products for genes affiliated with Arachnoid Cysts

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Sources for Arachnoid Cysts

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet