MCID: ARC007
MIFTS: 62

Arachnoid Cysts malady

Rare diseases, Neuronal diseases, Endocrine diseases, Fetal diseases categories
Download this MalaCard

Summaries for Arachnoid Cysts

About this section


Fully expand this MalaCard
NIH Rare Diseases:42 Arachnoid cysts are sacs filled with cerebrospinal fluid (csf) that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord. arachnoid cysts can be primary or secondary. primary arachnoid cysts are congenital (present at birth), resulting from abnormal development of the brain and spinal cord during early pregnancy. secondary arachnoid cysts are less common and result from head injuries, meningitis, tumors, or as a complication of brain surgery. signs and symptoms depend on the location and size of the cyst and may include headache, nausea and vomiting, seizures, hearing and visual disturbances, vertigo, and difficulties with balance and walking. although many affected individuals develop symptoms in the first year of life, some never develop symptoms. whether and how to treat the condition depends on the location and size of the cyst; when treatment is recommended, it may include placing a shunt to drain the fluid; surgically removing the cyst membranes; or opening the cyst so the fluid can drain into the csf. last updated: 7/11/2013

MalaCards based summary: Arachnoid Cysts, also known as intracranial arachnoid cysts, is related to precocious puberty and hypopituitarism, and has symptoms including An important gene associated with Arachnoid Cysts is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)), and among its related pathways are Nuclear signaling by ERBB4 and Phospholipase-C Pathway. The compounds ammonium and anastrozole have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

NINDS:43 Arachnoid cysts are cerebrospinal fluid-filled sacs that are located between the brain or spinal cord and the arachnoid membrane, one of the three membranes that cover the brain and spinal cord.

Wikipedia:65 Arachnoid cysts are cerebrospinal fluid covered by arachnoidal cells and collagen that may develop... more...

Descriptions from OMIM:46 182990,207790

Aliases & Classifications for Arachnoid Cysts

About this section
Sources:
42NIH Rare Diseases, 22GTR, 43NINDS, 48Orphanet, 46OMIM, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet, 35MESH via Orphanet
See all sources

Arachnoid Cysts, Aliases & Descriptions:

Name: Arachnoid Cysts 42 43 62
Intracranial Arachnoid Cysts 42 22 62
 
Arachnoid Cyst 48 46
Arachnoid Cysts, Intracranial 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Fetal diseases
Anatomical: Neuronal diseases, Endocrine diseases


Characteristics (Orphanet epidemiological data):

48
arachnoid cyst:
Inheritance: Autosomal recessive,Sporadic; Age of onset: Childhood; Age of death: Normal


External Ids:

ICD10 via Orphanet26 G93.0
UMLS via Orphanet63 C0078981
MESH via Orphanet35 D016080

Related Diseases for Arachnoid Cysts

About this section

Graphical network of the top 20 diseases related to Arachnoid Cysts:



Diseases related to arachnoid cysts

Symptoms for Arachnoid Cysts

About this section

Symptoms by clinical synopsis from OMIM:

182990

Clinical features from OMIM:

182990,207790

HPO human phenotypes related to Arachnoid Cysts:

(show all 8)
id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 abnormality of the vertebral column HP:0000925
3 paraplegia HP:0010550
4 autosomal recessive inheritance HP:0000007
5 microcephaly HP:0000252
6 macrocephaly HP:0000256
7 intellectual disability HP:0001249
8 arachnoid cyst HP:0100702

Drugs & Therapeutics for Arachnoid Cysts

About this section

Drug clinical trials:

Search ClinicalTrials for Arachnoid Cysts

Search NIH Clinical Center for Arachnoid Cysts

Genetic Tests for Arachnoid Cysts

About this section

Genetic tests related to Arachnoid Cysts:

id Genetic test Affiliating Genes
1 Arachnoid Cysts, Intracranial22

Anatomical Context for Arachnoid Cysts

About this section

MalaCards organs/tissues related to Arachnoid Cysts:

32
Spinal cord, Brain, Temporal lobe, Pituitary, Bone, Cortex, Cerebellum, Kidney, Testis, Cingulate cortex

Animal Models for Arachnoid Cysts or affiliated genes

About this section

MGI Mouse Phenotypes related to Arachnoid Cysts:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053908.2SLC12A2, FOXC2, PGR, GNRH1
2MP:00053797.8GNRH1, PGR, GH1, SLC12A2
3MP:00036317.4SPAST, GNRH1, FOXC2, GH1, COL4A1, SLC12A2
4MP:00053897.3SLC12A2, COL4A1, GH1, PGR, GNRH1, SPAST

Publications for Arachnoid Cysts

About this section

Articles related to Arachnoid Cysts:

(show top 50)    (show all 594)
idTitleAuthorsYear
1
Surgical management of intracranial arachnoid cysts: clinical and radiological outcome. (23546896)
2013
2
Cluster headache and arachnoid cyst. (23419954)
2013
3
Arachnoid cysts in tuberous sclerosis complex. (24325802)
2013
4
Bilateral retrocerebellar arachnoid cysts exerting mass effect and associated with cerebellar tonsillar ectopia in an otherwise healthy adult. (23615422)
2013
5
Endonasal management of sellar arachnoid cysts: simple cyst obliteration technique. (22283187)
2012
6
Should we resect all multiple intraspinal extradural arachnoid cysts? A case report. (22843467)
2012
7
Surgical management strategies of intracranial arachnoid cysts: a single institution experience of 75 cases. (23015336)
2012
8
CT cisternography in intracranial symptomatic arachnoid cysts: classification and treatment. (22520095)
2012
9
A case of an arachnoid cyst masquerading as corticobasal degeneration. (23061395)
2012
10
Transient paraplegia after accidental insertion of an epidural catheter into an arachnoid cyst. (21897183)
2011
11
Endoscopic treatment of suprasellar arachnoid cysts in children. (21721882)
2011
12
Arachnoid cysts of the fourth ventricle - short illustrated review. (19387540)
2010
13
Spinal cord compression caused by idiopathic intradural arachnoid cysts of the spine: review of the literature and illustrated case. (19763637)
2010
14
Guidelines for the management of obstructive hydrocephalus from suprasellar-prepontine arachnoid cysts using endoscopic third ventriculocystocisternostomy. (20688773)
2010
15
Spinal extradural arachnoid cysts in lymphedema-distichiasis syndrome. (20535019)
2010
16
Multiple extradural spinal arachnoid cysts: a case report and review of the literature. (19829999)
2009
17
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. (18400590)
2008
18
A case with giant arachnoid cysts manifested as migraine. (19116706)
2008
19
Intrasacral extradural arachnoid cysts. (18497497)
2008
20
Asymptomatic massive subdural hematoma in a patient with bitemporal agenesis and bilateral temporal arachnoid cysts. (18364667)
2008
21
Regression of syringomyelia and tonsillar herniation after posterior fossa arachnoid cyst excision. Case report and literature review. (17622461)
2007
22
Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. Case report and review of the literature. (16302620)
2005
23
Cystoventricular shunting of intracranial arachnoid cysts. (14734867)
2003
24
Do quiescent arachnoid cysts alter CNS functional organization?: A fMRI and morphometric study. (12499486)
2002
25
Apparent paradoxical vault changes with middle cranial fossa arachnoid cysts--implication for aetiology. (11895303)
2001
26
Children with bilateral temporal arachnoid cysts may have glutaric aciduria type 1 (GAT1); operation without knowing that may be harmful. (11086812)
2000
27
A case report of caudal regression syndrome associated with an intraspinal arachnoid cyst. (10705931)
1999
28
Anterior thoracic intradural arachnoid cysts. Case report and review of the literature. (17031914)
1999
29
Arachnoid cysts associated with post-traumatic and spontaneous rupture into the subdural space. (9690007)
1997
30
Surgical options in the treatment of interhemispheric arachnoid cysts. (8781589)
1996
31
Bilateral arachnoid cysts, seizures and severe encephalopathy: case report. (8208351)
1994
32
Nontraumatic intradiploic arachnoid cysts--report of five cases. (1282679)
1992
33
Endoscopic treatment of suprasellar arachnoid cysts. (1481755)
1992
34
Do arachnoid cysts grow? A retrospective CT volumetric study. (1922751)
1991
35
Intermittent downbeat nystagmus secondary to vermian arachnoid cyst with associated obstructive hydrocephalus. (1838553)
1991
36
A variant of the syndrome of spinal arachnoid cysts with multiple congenital defects. (2021437)
1991
37
Arachnoiditis ossificans with arachnoid cyst after cranial tuberculous meningitis. (2320252)
1990
38
The value of MRI in the study of spinal extradural arachnoid cysts. (2346931)
1990
39
Middle fossa arachnoid cysts. (2583835)
1989
40
MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. (2505512)
1989
41
Magnetic resonance imaging of arachnoid cysts. (2598110)
1989
42
Otolaryngologic manifestations of posterior fossa arachnoid cysts. (3999903)
1985
43
Arachnoid cysts of the sylvian fissure. Evidence of fluid secretion. (6231356)
1984
44
Arachnoid cysts of the posterior fossa. Report of three cases. (6858736)
1983
45
Spinal intradural arachnoid cysts. (7110485)
1982
46
Multiple spinal arachnoid cysts: the role of oily contrast medium. (6264636)
1981
47
Arachnoid cysts in children: ultrastructural findings. (6939278)
1981
48
Posterior fossa arachnoid cysts. (501222)
1979
49
Infratentorial arachnoid cysts. (4542573)
1973
50
Congenital spinal arachnoid cysts; report of two cases and review of the literature. (5418175)
1970

Variations for Arachnoid Cysts

About this section

Expression for genes affiliated with Arachnoid Cysts

About this section
Expression patterns in normal tissues for genes affiliated with Arachnoid Cysts

Search GEO for disease gene expression data for Arachnoid Cysts.

Pathways for genes affiliated with Arachnoid Cysts

About this section

Pathways related to Arachnoid Cysts according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.5GH1, PGR
2
Show member pathways
9.0COL4A1, GH1, GNRH1

Compounds for genes affiliated with Arachnoid Cysts

About this section

Compounds related to Arachnoid Cysts according to GeneCards/GeneDecks:

(show top 50)    (show all 66)
idCompoundScoreTop Affiliating Genes
1ammonium4410.0MIP, GH1
2anastrozole44 50 1111.9GH1, PGR
3triphenylethylene449.9DYT10, PGR
4gestrinone449.8PGR, GNRH1
5adenosine 3,5-cyclic monophosphorothioate449.8DYT10, GNRH1
6naltrexone44 28 50 1112.8GH1, GNRH1
7estradiol benzoate449.8GNRH1, PGR
8nilutamide44 61 28 1112.7PGR, GNRH1
9goserelin44 28 1111.7GNRH1, PGR
10cabergoline44 28 1111.7GH1, GNRH1
111-(5-isoquinolinylsulfonyl)-2-methylpiperazine449.7DYT10, GNRH1
12allopregnanolone449.7PGR, GNRH1
13metoclopramide44 50 1111.7GH1, GNRH1
14buserelin44 28 1111.7GNRH1, PGR
15trifluoperazine44 28 50 1112.7DYT10, GH1
16toremifene44 1110.7GNRH1, PGR
17tibolone449.7PGR, GNRH1
18danazol44 24 1111.7GNRH1, PGR
19cyproteroneacetate449.7PGR, GNRH1
20spironolactone44 61 28 50 1113.6PGR, GNRH1
21pertussis449.6GH1, DYT10
22flutamide44 61 1111.6PGR, GNRH1
23steroidal449.6PGR, GNRH1
24pkcs449.5GNRH1, DYT10
25diethylstilbestrol44 28 1111.5GNRH1, PGR
26bromocriptine44 28 1111.5GH1, GNRH1
27leuprolide acetate449.3GH1, PGR, GNRH1
28clomiphene citrate449.3GH1, PGR, GNRH1
29progestins449.3GH1, PGR, GNRH1
30raloxifene44 50 28 1112.3PGR, GNRH1, GH1
31estrone44 28 24 1112.3GH1, PGR, GNRH1
32verapamil44 28 50 24 1113.3GNRH1, GH1, DYT10
33naloxone44 28 50 1112.3GH1, GNRH1
34nifedipine44 28 50 1112.3GH1, DYT10, GNRH1
35dihydrotestosterone44 28 24 1112.3GH1, PGR, GNRH1
36thyroxine44 2410.3GNRH1, PGR, GH1
37dmso449.3GH1, PGR, GNRH1
38ribonucleic acid449.2GNRH1, GH1, PGR
39dehydroepiandrosterone sulfate449.1GNRH1, GH1
40actinomycin d449.1DYT10, GNRH1, GH1
41vegf449.0GH1, MIP, PGR, DYT10
42dexamethasone44 50 28 1111.9GH1, GNRH1, PGR, MIP
43estradiol44 24 1110.9GH1, GNRH1, PGR
44gaba448.9SLC12A2, GNRH1, PGR
45gnrh448.8PGR, DYT10, GNRH1, GH1
46tamoxifen44 50 28 1111.8GNRH1, DYT10, GH1, PGR
47adenylate448.8DYT10, PGR, GH1, GNRH1
48forskolin44 50 1110.7GH1, DYT10, SLC12A2
49retinoic acid44 249.6DYT10, GH1, GNRH1, PGR
50glutamate448.5GNRH1, MIP, SLC12A2, DYT10

GO Terms for genes affiliated with Arachnoid Cysts

About this section

Biological processes related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1patterning of blood vesselsGO:0015699.7COL4A1, FOXC2

Molecular functions related to Arachnoid Cysts according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1hormone activityGO:0051799.4GH1, GNRH1

Products for genes affiliated with Arachnoid Cysts

About this section
  • Antibodies
  • Proteins
  • Lysates

Sources for Arachnoid Cysts

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet