MCID: ARC002
MIFTS: 41

Arachnoiditis malady

Categories: Rare diseases, Neuronal diseases, Genetic diseases

Aliases & Classifications for Arachnoiditis

Aliases & Descriptions for Arachnoiditis:

Name: Arachnoiditis 12 50 51 42 14 69
Familial Spinal Arachnoiditis 69
Spinal Arachnoiditis 50

Classifications:



External Ids:

Disease Ontology 12 DOID:12156
ICD10 33 G03
MeSH 42 D001100
NCIt 47 C37913
UMLS 69 C0003708

Summaries for Arachnoiditis

NIH Rare Diseases : 50 arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. the inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. it may result in scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. in some people. it may affect the bladder, bowel, and sexual function. very severe arachnoiditis can result in paralysis of the legs. treatment aims to relieve pain and improve symptoms that impair function. treatment may include pain medications, physical therapy, and psychotherapy. surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue. last updated: 8/17/2016

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to arachnoid cysts and spinal intradural arachnoid cysts, and has symptoms including arthralgia, fatigue and muscle weakness. An important gene associated with Arachnoiditis is MNX1 (Motor Neuron And Pancreas Homeobox 1). The drugs Dexamethasone and Bupivacaine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

NINDS : 51 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 71 Arachnoiditis is an inflammatory condition of the arachnoid mater or \'arachnoid\', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 205)
id Related Disease Score Top Affiliating Genes
1 arachnoid cysts 12.5
2 spinal intradural arachnoid cysts 12.3
3 spinal arachnoiditis 12.1
4 pachygyria with mental retardation, seizures, and arachnoid cysts 12.0
5 tibia absent polydactyly arachnoid cyst 11.9
6 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 11.8
7 syringomyelia 11.3
8 intracranial cysts 11.2
9 meningitis 11.1
10 chudley-mccullough syndrome 11.1
11 autosomal dominant polycystic kidney disease 11.1
12 meningioma, familial 11.0
13 neurocutaneous melanosis, somatic 10.9
14 amyloidosis, hereditary, transthyretin-related 10.7
15 hydrocephalus 10.2
16 pulmonary edema 10.0 MNX1 MRI1
17 aneurysm 10.0
18 tuberculous meningitis 10.0
19 cauda equina syndrome 9.9
20 cervicitis 9.9
21 cerebritis 9.9
22 headache 9.9
23 pulmonary hypertension 9.9 MT-ND1 POMC
24 spondylitis 9.8
25 communicating hydrocephalus 9.8
26 autosomal recessive nonsyndromic deafness 9.8 MT-ND1 POMC
27 glioma 9.7
28 epilepsy 9.7
29 intracranial hypertension 9.7
30 obstructive hydrocephalus 9.7
31 paraplegia 9.7
32 syringohydromyelia 9.7
33 cranial nerve palsy 9.7
34 normal pressure hydrocephalus 9.7
35 bobble-head doll syndrome 9.7
36 trigeminal neuralgia 9.7
37 optic nerve glioma 9.7
38 distichiasis 9.6
39 choroiditis 9.6
40 precocious puberty 9.6
41 hemifacial spasm 9.6
42 neuroma 9.6
43 spasticity 9.6
44 lymphedema 9.6
45 adenoma 9.6
46 meningocele 9.6
47 radiculopathy 9.6
48 peritonitis 9.6
49 head injury 9.6
50 chiari malformation 9.6

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

32 (show all 13)
id Description HPO Frequency HPO Source Accession
1 arthralgia 32 HP:0002829
2 fatigue 32 HP:0012378
3 muscle weakness 32 HP:0001324
4 hydrocephalus 32 HP:0000238
5 hearing impairment 32 HP:0000365
6 abnormality of vision 32 HP:0000504
7 urinary bladder sphincter dysfunction 32 HP:0002839
8 migraine 32 HP:0002076
9 paresthesia 32 HP:0003401
10 meningitis 32 HP:0001287
11 hyporeflexia 32 HP:0001265
12 tinnitus 32 HP:0000360
13 anhidrosis 32 HP:0000970

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 58)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
2
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
3 Dexamethasone acetate Phase 4 1177-87-3
4 glucocorticoids Phase 4
5
protease inhibitors Phase 4
6 Gastrointestinal Agents Phase 4
7 HIV Protease Inhibitors Phase 4
8 Hormone Antagonists Phase 4
9 Dexamethasone 21-phosphate Phase 4
10 Anesthetics Phase 4
11 Hormones Phase 4
12 Peripheral Nervous System Agents Phase 4
13 Anesthetics, Local Phase 4
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
15 Antiemetics Phase 4
16 Anti-Inflammatory Agents Phase 4
17 BB 1101 Phase 4
18 Autonomic Agents Phase 4
19 Antineoplastic Agents, Hormonal Phase 4
20 Central Nervous System Depressants Phase 4
21
Etoposide Approved Phase 2 33419-42-0 36462
22
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
23
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
24
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
25
Busulfan Approved, Investigational Phase 2 55-98-1 2478
26
rituximab Approved Phase 2 174722-31-7 10201696
27
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
28
Ifosfamide Approved Phase 2 3778-73-2 3690
29
Mechlorethamine Approved Phase 2 51-75-2 4033
30
Thiotepa Approved Phase 2 52-24-4 5453
31
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
32
Carmustine Approved Phase 2 154-93-8 2578
33
leucovorin Approved, Nutraceutical Phase 2 58-05-9 54575, 6560146 143
34
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
35 Angiogenesis Inhibitors Phase 2
36 Angiogenesis Modulating Agents Phase 2
37 Anti-Bacterial Agents Phase 2
38 Anti-Infective Agents Phase 2
39 Immunosuppressive Agents Phase 2
40 Alkylating Agents Phase 2
41 Folic Acid Antagonists Phase 2
42 Cortisol succinate Phase 2
43 Topoisomerase Inhibitors Phase 2
44 Nucleic Acid Synthesis Inhibitors Phase 2
45 Dermatologic Agents Phase 2
46 Vitamin B Complex Phase 2
47 Hydrocortisone 17-butyrate 21-propionate Phase 2
48 Hydrocortisone acetate Phase 2
49 Etoposide phosphate Phase 2
50 Isophosphamide mustard Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2
4 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
5 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

39
Spinal Cord, Brain, Bone, Temporal Lobe, Pituitary, Skin, Endothelial

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 1154)
id Title Authors Year
1
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
2
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )
2017
3
Post-procedure adhesive arachnoiditis following obstetric spinal anaesthesia. ( 27212734 )
2016
4
Treatment of Middle Cranial Fossa Arachnoid Cysts: A Systematic Review and Meta-Analysis. ( 27319312 )
2016
5
Surgery for intracranial arachnoid cysts in children-a prospective long-term study. ( 27000761 )
2016
6
Septooptic Dysplasia with an Associated Arachnoid Cyst. ( 27891281 )
2016
7
The Acetazolamide Challenge: A Tool for Surgical Decision Making and Predicting Surgical Outcome in Patients with Arachnoid Cysts. ( 27415592 )
2016
8
Syringomyelia secondary to "occult" dorsal arachnoid webs: Report of two cases with review of literature. ( 27217656 )
2016
9
Sport-related structural brain injury associated with arachnoid cysts: a systematic review and quantitative analysis. ( 27032926 )
2016
10
Prevalence and symptoms of intracranial arachnoid cysts: a population-based study. ( 26860092 )
2016
11
Syringomyelia caused by an arachnoid web in a patient with shunted Dandy-Walker malformation. ( 27822765 )
2016
12
Digital Subtraction Cystography for Detection of Communicating Holes of Spinal Extradural Arachnoid Cysts. ( 26798223 )
2016
13
Spinal intradural hydatid cyst causing arachnoiditis: A rare etiology of cauda equina syndrome. ( 27891041 )
2016
14
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
15
Transfrontal Transaqueductal, Transtrigonal, and Suboccipital Infratentorial Supracerebellar Endoscopic Fenestration of Posterior Fossa Arachnoid Cysts: Three Surgical Cases. ( 26968147 )
2016
16
Radiological diagnosis of spinal arachnoid cysts: A pictorial essay. ( 27160059 )
2016
17
Clinical and Radiographical Differences Between Thoracic Idiopathic Spinal Cord Herniation and Spinal Arachnoid Cyst. ( 27926670 )
2016
18
Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )
2016
19
Atypical cause of radiculopathy - Intradural spinal arachnoid cyst. ( 27104760 )
2016
20
Motor Speech Apraxia in a 70-Year-Old Man with Left Dorsolateral Frontal Arachnoid Cyst: A [(18)F]FDG PET-CT Study. ( 28003922 )
2016
21
Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region. ( 26728365 )
2016
22
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27406556 )
2016
23
Snare technique for the remodeling of the redundant arachnoid pouch to prevent cerebrospinal fluid rhinorrhea and hematoma collection during transsphenoidal surgery for suprasellar-extended pituitary tumors. ( 26967785 )
2016
24
Pediatric intraventricular arachnoid cysts in the body of lateral ventricle: surgical outcome and its embryologic background. ( 27492334 )
2016
25
Sports participation with arachnoid cysts. ( 26636254 )
2016
26
Letter to the Editor: Are arachnoid cysts and Chiari malformation Type I more common in those with postconcussion syndrome? ( 27611207 )
2016
27
Assessment of endoscopic treatment for quadrigeminal cistern arachnoid cysts: A 7-year experience with 28 cases. ( 26590025 )
2016
28
Transsacrococcygeal approach to ganglion impar block for treatment of chronic coccygodynia after spinal arachnoid cyst removal: A case report. ( 27684866 )
2016
29
Low-Cost Interactive Image-Based Virtual Endoscopy for the Diagnosis and Surgical Planning of Suprasellar Arachnoid Cysts. ( 26732948 )
2016
30
Intramedullary cyst formation after removal of multiple intradural spinal arachnoid cysts: A case report. ( 27512608 )
2016
31
Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. ( 27625266 )
2016
32
Response to "Syringomyelia secondary to 'occult' dorsal arachnoid webs: Report of two cases with review of literature" by Sayal et al. ( 27630482 )
2016
33
Supraorbital Keyhole Microsurgical Fenestration of Symptomatic Temporal Arachnoid Cysts in Children: Advantages and Limitations. ( 27873293 )
2016
34
Spinal extradural arachnoid cyst: A rare cause of neurogenic bladder. ( 27365974 )
2016
35
Episodic Headache and Arachnoid Cyst Related Subdural Hematoma. ( 27197943 )
2016
36
Comparative analysis of bleeding risk by the location and shape of arachnoid cysts: a finite element model analysis. ( 27718069 )
2016
37
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27379494 )
2016
38
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 27777344 )
2016
39
Children With Arachnoid Cysts Who Sustain Blunt Head Trauma: Injury Mechanisms and Outcomes. ( 26728086 )
2016
40
Endoscopic and microsurgical treatment of Sylvian fissure arachnoid cysts - clinical and radiological outcome. ( 25818148 )
2015
41
Clinical characteristics and treatment strategies for idiopathic spinal extradural arachnoid cysts: a single-center experience. ( 25520051 )
2015
42
PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss. ( 26418719 )
2015
43
A symptomatic spinal extradural arachnoid cyst with lumbar disc herniation. ( 25861499 )
2015
44
Teaching NeuroImages: Optic nerve glioma with perineural arachnoid gliomatosis in a patient with neurofibromatosis-1. ( 25825471 )
2015
45
Neuroendoscopic treatment for hydrocephalus associated to midline arachnoid cysts in a series of nine pediatric patients. ( 26041004 )
2015
46
Arachnoiditis ossificans after spinal surgery. ( 25970374 )
2015
47
Endoscopic Treatment of Temporal Arachnoid Cysts in 34 Patients. ( 25968965 )
2015
48
Gradually progressive symptoms of normal pressure hydrocephalus caused by an arachnoid cyst in the fourth ventricle: A case report. ( 26342780 )
2015
49
Bell's palsy in association with a cerebellar arachnoid cyst. ( 25878242 )
2015
50
Clinical and radiological outcomes of surgical treatment for symptomatic arachnoid cysts in adults. ( 26154148 )
2015

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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