MCID: ARC002
MIFTS: 51

Arachnoiditis malady

Neuronal category

Summaries for Arachnoiditis

Sources:
43NIH Rare Diseases, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord. the arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures. inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. arachnoiditis is difficult to treat and long-term outcomes are unpredictable. last updated: 2/12/2010

MalaCards: Arachnoiditis, also known as adhesive arachnoiditis, is related to adenoma and arachnoid cysts, and has symptoms including motor deficit/trouble, sphincter dysfunction and hydrocephaly. An important gene associated with Arachnoiditis is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)). The compounds gestrinone and triphenylethylene have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and brain, and related mouse phenotypes are nervous system and reproductive system.

NINDS:44 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.

Wikipedia:64 Arachnoiditis is inflammation of the arachnoid, one of the membranes known as meninges that surround and... more...

Description from OMIM:47 182950

Aliases & Classifications for Arachnoiditis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 44NINDS, 49Orphanet, 47OMIM, 61UMLS, 40NCIt, 57SNOMED-CT, 35MeSH, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
arachnoiditis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

arachnoiditis 8 43 44 49 47 61
adhesive arachnoiditis 49 61
chronic arachnoiditis 49
other meningitis nos 8
spinal arachnoiditis 43


External Ids:

Disease Ontology8 DOID:12156
NCIt40 C37913
MeSH35 D001100
SNOMED-CT via Orphanet58 8217007
UMLS via Orphanet62 C0003708
OMIM47 182950
MESH via Orphanet36 D001100

Related Diseases for Arachnoiditis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1adenoma30.1GH1, GNRH1, SSTR1
2arachnoid cysts11.2
3intracranial cysts10.8
4syringomyelia10.7
5spinal intradural arachnoid cysts10.5
6tuberculous meningitis10.4
7cauda equina syndrome10.4
8tibia absent polydactyly arachnoid cyst10.3
9ankylosing spondylitis10.3
10spondylitis10.3
11headache10.2
12normal pressure hydrocephalus10.1
13obstructive hydrocephalus10.1
14corpus callosum agenesis10.1
15mental retardation10.1
16syringohydromyelia10.1
17retrocerebellar cyst10.1
18intracranial hypotension10.1
19meningocele10.1
20spinal stenosis10.1
21trigeminal neuralgia10.1
22n syndrome10.1
23bobble-head doll syndrome10.1
24back pain10.1
25head injury10.1
26secondary syringomyelia10.1
27idiopathic syringomyelia10.1
28pituitary apoplexy10.0GNRH1
29endolymphatic hydrops10.0MIP
30hyperprolactinemia10.0GNRH1, GH1
31hypothalamic disease10.0GH1, GNRH1
32meningioma10.0PGR, PTGDS
33gonadal disease10.0GH1, GNRH1
34azoospermia10.0PTGDS, GNRH1
35obesity10.0FOXC2, GH1, MIP
36pituitary gland disease10.0GH1, GNRH1
37polycystic ovary syndrome10.0GNRH1, GH1
38gigantism10.0GH1
39pituitary tumors10.0GNRH1, GH1, SSTR1
40prolactinoma10.0SSTR1, GNRH1, GH1
41choriocarcinoma10.0GNRH1, GH1
42diabetes mellitus10.0FOXC2, DYT10, GH1
43acromegaly10.0SSTR1, GNRH1, GH1
44foster-kennedy syndrome10.0
45dandy-walker syndrome10.0
46pseudotumor cerebri10.0
47sensorineural hearing loss10.0
48epidural abscess10.0
49radiculopathy10.0
50tuberous sclerosis10.0

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to arachnoiditis

Clinical Features for Arachnoiditis

Sources:
47OMIM, 49Orphanet
See all sources

Clinical features from OMIM:

182950

Clinical synopsis from OMIM:

182950

Symptoms:

49 (show all 16)
  • motor deficit/trouble
  • sphincter dysfunction
  • hydrocephaly
  • muscle weakness/flaccidity
  • hearing loss/hypoacusia/deafness
  • asthenia/fatigue/weakness
  • articular/joint pain/arthralgia
  • anomalies of eyes and vision
  • sensitive trouble/deficit
  • anomalies of ear and hearing
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • areflexia/hyporeflexia
  • facial pain/cephalalgia/migraine
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • meningitis/meningeal syndrome
  • tinnitus

Drugs & Therapeutics for Arachnoiditis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Arachnoiditis

Drug clinical trials:

Search ClinicalTrials for Arachnoiditis

Search NIH Clinical Center for Arachnoiditis

Search CenterWatch for Arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

Sources:
33MalaCards
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MalaCards organs/tissues related to Arachnoiditis:

33
Skin, Spinal cord, Brain, Pituitary

Animal Models for Arachnoiditis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Arachnoiditis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.1COL4A1, GNRH1, FOXC2, CRLF1, GH1, SSTR1
2MP:00053898.9COL4A1, GNRH1, GH1, MAP3K9, RICTOR, PGR

Publications for Arachnoiditis

Sources:
51PubMed
See all sources

Articles related to Arachnoiditis:

(show top 50)    (show all 410)
idTitleAuthorsYear
1
Arachnoiditis ossificans in a patient with ankylosing spondylitis, syringomyelia, and a history of spinal surgery. (23948833)
2013
2
Arachnoiditis ossificans of the cauda equina. (22239274)
2012
3
The effects of intrathecal injection of a hyaluronan-based hydrogel on inflammation, scarring and neurobehavioural outcomes in a rat model of severe spinal cord injury associated with arachnoiditis. (22459192)
2012
4
Experimental syringohydromyelia induced by adhesive arachnoiditis in the rabbit: changes in the blood-spinal cord barrier, neuroinflammatory foci, and syrinx formation. (22439613)
2012
5
Iophendylate myelography induced thoracic arachnoiditis, arachnoid cyst and syrinx, four decades later. (20979434)
2010
6
Adhesive arachnoiditis following percutaneous cervical cordotomy--may we still use lipiodol? (18823752)
2008
7
Thoracic arachnoiditis, arachnoid cyst and syrinx formation secondary to myelography with Myodil, 30 years previously. (16944225)
2006
8
Arachnoid cyst with associated arachnoiditis developing after subarachnoid hemorrhage. Case report. (16381198)
2005
9
Obstetric epidural and chronic adhesive arachnoiditis. (15113765)
2004
10
Optochiasmal arachnoiditis following cotton wrapping of anterior communicating artery aneurysm treated by surgical removal of granuloma. (12637066)
2003
11
Syrinx and tuberculoma formation in tuberculous arachnoiditis. (11383941)
2001
12
Arachnoiditis associated with arachnoid cyst formation and cord tethering following myelography: magnetic resonance features. (11380373)
2001
13
Ruptured spinal dermoid cyst with chemical arachnoiditis and disseminated intracranial lipid droplets. (7761002)
1995
14
Muslin-induced optic arachnoiditis ("gauzoma"): findings on CT and MR. (8491918)
1993
15
Toward a rational therapeutic strategy for arachnoiditis. A possible role for d-penicillamine. (2011771)
1991
16
Benign lumbar arachnoiditis: MR imaging with gadopentetate dimeglumine. (2114765)
1990
17
The long-range prognosis of arachnoiditis. (2617363)
1989
18
Empty sella syndrome caused by syphilitic arachnoiditis. (3951113)
1986
19
Pathogenesis of postmyelographic arachnoiditis. (3980181)
1985
20
Case report: computed tomography findings in spinal arachnoiditis ossificans. (6411435)
1983
21
Arachnoiditis ossificans. A case report diagnosed with computerized axial tomography. (6867851)
1983
22
Spinal arachnoiditis ossificans: case report. (6843804)
1983
23
Chronic arachnoiditis in the posterior fossa: a study of 82 cases. (6981688)
1982
24
Arachnoiditis ossificans. (6811629)
1982
25
Adhesive arachnoiditis in patients with spinal block. (7063116)
1982
26
Tuberculous optochiasmatic arachnoiditis. (7322330)
1981
27
Persistent neurologic deficit and adhesive arachnoiditis following intrathecal 2-chloroprocaine injection. (7189987)
1980
28
Unusual effects of metrizamide lumbar myelography. Constellation of aseptic meningitis, arachnoiditis, communicating hydrocephalus, and Guillaine-BarrAc syndrome. (7417062)
1980
29
Spinal arachnoiditis: disease or coincidence? (7424611)
1980
30
Chronic spinal arachnoiditis. (698548)
1978
31
Comparison of arachnoiditis produced by meglumine iocarmate and metrizamide myelography in an animal model. (97964)
1978
32
Thorotrast induced adhesive arachnoiditis associated with meningioma and schwannoma. (306957)
1978
33
Chronic arachnoiditis after a pantopaque study of the posterior fossa. (1265523)
1976
34
Adhesive arachnoiditis after lumbar radiculography with Dimer-X and Depo-Medrol. (1257435)
1976
35
Familial spinal arachnoiditis. A new entity. (4816834)
1974
36
Opto-chiasmatic arachnoiditis. Report of two cases with unusual apparent etiologic factors. (4465411)
1974
37
Hyperosmolality of the cerebrospinal fluid as a cause of adhesive arachnoiditis in lumbar myelography. (4463698)
1974
38
Water-soluble contrast media and adhesive arachnoiditis. II. Reinvestigation of operated cases. (4362555)
1974
39
A case of chronic adhesive arachnoiditis after lumbar myelography with methiodal-sodium. (4363898)
1972
40
Diagnosis of spinal arachnoiditis by air myelography. (5807457)
1969
41
Spinal arachnoiditis. (5709930)
1968
42
Intrathecal steroid administration in postoperative arachnoiditis. (5240622)
1968
43
Experimental studies of pantopaque arachnoiditis. 3. Clinical studies in progress. (5915430)
1966
44
Experimental studies of pantopaque arachnoiditis. II. Laboratory studies. (5915429)
1966
45
Spinal arachnoiditis. (14466403)
1962
46
Chronic arachnoiditis and hydrocephalus in the surgical management of acoustic tumours; a plea for early operation. (13614392)
1958
47
Progressive course of arachnoiditis simulating syringomyelia. (13038821)
1952
48
Chronic adhesive arachnoiditis; probably due to virus of lymphogranuloma venereum. (18113373)
1949
49
Recurrent retrobulbar neuritis; chiasmal arachnoiditis. (18872486)
1948
50
Circumscribed spinal arachnoiditis with cavitation of the spinal cord; report of a case. (20285685)
1946

Genetic Variations for Arachnoiditis

Expression for genes affiliated with Arachnoiditis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for genes affiliated with Arachnoiditis

Compounds for genes affiliated with Arachnoiditis

Sources:
45Novoseek, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Arachnoiditis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1gestrinone4510.5GNRH1, PGR
2triphenylethylene4510.4PGR, DYT10
3estradiol benzoate4510.4PGR, GNRH1
4adenosine 3,5-cyclic monophosphorothioate4510.4DYT10, GNRH1
5nilutamide45 60 29 1113.4GNRH1, PGR, SACS
6leuprolide acetate4510.4PGR, GNRH1, GH1
7flutamide45 60 1112.4GNRH1, SACS, PGR
8clomiphene citrate4510.4PGR, GH1, GNRH1
9goserelin45 29 1112.4GNRH1, PGR
10progestins4510.4GNRH1, GH1, PGR
11raloxifene45 29 50 1113.4PGR, GNRH1, GH1
121-(5-isoquinolinylsulfonyl)-2-methylpiperazine4510.3DYT10, GNRH1
13allopregnanolone4510.3GNRH1, PGR
14octreotide45 60 29 1113.2GH1, GNRH1, SSTR1
15anastrozole45 1111.2PGR, GH1
16buserelin45 29 1112.2GNRH1, PGR
17estrone45 29 11 2413.1PGR, GNRH1, GH1
18gnrh4510.1PGR, DYT10, GNRH1, GH1
19ribonucleic acid4510.1SSTR1, GH1, GNRH1, PGR
20tamoxifen45 50 29 1113.0GNRH1, DYT10, GH1, PGR
21lanreotide45 2911.0SSTR1, GH1
22nifedipine45 50 29 1113.0GH1, DYT10, GNRH1
23testosterone45 60 11 2412.9PTGDS, PGR, GH1, SACS, GNRH1
24adenylate459.9DYT10, GH1, SSTR1, PGR, GNRH1
25verapamil45 50 29 11 2413.7GH1, DYT10, GNRH1

GO Terms for genes affiliated with Arachnoiditis

Products for genes affiliated with Arachnoiditis

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Sources for Arachnoiditis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet