MCID: ARC002
MIFTS: 47

Arachnoiditis malady

Categories: Genetic diseases, Rare diseases, Neuronal diseases

Aliases & Classifications for Arachnoiditis

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 46NINDS, 12DISEASES, 51Orphanet, 36MeSH, 65UMLS, 27ICD10, 42NCIt, 59SNOMED-CT, 37MESH via Orphanet, 66UMLS via Orphanet, 61The Human Phenotype Ontology
See all MalaCards sources

Aliases & Descriptions for Arachnoiditis:

Name: Arachnoiditis 10 45 46 12 51 36 65
Adhesive Arachnoiditis 51 65
Familial Spinal Arachnoiditis 65
 
Chronic Arachnoiditis 51
Other Meningitis Nos 10
Spinal Arachnoiditis 45

Characteristics:

Orphanet epidemiological data:

51
arachnoiditis:
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy


Classifications:



External Ids:

Disease Ontology10 DOID:12156
ICD1027 G03
MeSH36 D001100
NCIt42 C37913
Orphanet51 137817
MESH via Orphanet37 D001100
UMLS via Orphanet66 C0003708
UMLS65 C0003708, C1710146, C0270617

Summaries for Arachnoiditis

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NIH Rare Diseases:45 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord. the arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures. inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. adhesive arachnoiditis is the most severe form, characterized by debilitating, intractable neurogenic back and limb pain and a range of other neurological problems. arachnoiditis is difficult to treat and long-term outcomes are unpredictable. a regimen of pain management, physiotheraphy, exercise, and psychotheraphy is often recommended. surgical treatment seem to offer only short-term relief. last updated: 9/18/2015

MalaCards based summary: Arachnoiditis, also known as adhesive arachnoiditis, is related to aseptic meningitis and arachnoid cysts, and has symptoms including paresthesia, arthralgia and muscle weakness. An important gene associated with Arachnoiditis is NEXN (Nexilin F-Actin Binding Protein). Affiliated tissues include spinal cord, brain and bone.

NINDS:46 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.

Wikipedia:68 Arachnoiditis is an inflammatory condition of the arachnoid mater or \'arachnoid\', one of the membranes... more...

Related Diseases for Arachnoiditis

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Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to arachnoiditis

Symptoms for Arachnoiditis

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Symptoms:

 51 (show all 16)
  • anomalies of eyes and vision
  • anomalies of ear and hearing
  • tinnitus
  • hearing loss/hypoacusia/deafness
  • meningitis/meningeal syndrome
  • motor deficit/trouble
  • areflexia/hyporeflexia
  • sensitive trouble/deficit
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • muscle weakness/flaccidity
  • articular/joint pain/arthralgia
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • hydrocephaly
  • facial pain/cephalalgia/migraine
  • sphincter dysfunction
  • asthenia/fatigue/weakness

HPO human phenotypes related to Arachnoiditis:

(show all 14)
id Description Frequency HPO Source Accession
1 paresthesia hallmark (90%) HP:0003401
2 arthralgia hallmark (90%) HP:0002829
3 muscle weakness hallmark (90%) HP:0001324
4 reduced tendon reflexes hallmark (90%) HP:0001315
5 meningitis hallmark (90%) HP:0001287
6 abnormality of the eye hallmark (90%) HP:0000478
7 hearing impairment hallmark (90%) HP:0000365
8 tinnitus hallmark (90%) HP:0000360
9 hypohidrosis typical (50%) HP:0000966
10 migraine occasional (7.5%) HP:0002076
11 hydrocephalus occasional (7.5%) HP:0000238
12 spastic paraparesis HP:0002313
13 abnormality of metabolism/homeostasis HP:0001939
14 abnormality of the skeletal system HP:0000924

UMLS symptoms related to Arachnoiditis:


agitation postoperative

Drugs & Therapeutics for Arachnoiditis

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Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Bupivacaineapproved, investigationalPhase 49642180-92-92474
Synonyms:
( inverted exclamation markA)-bupivacaine
(+-)-Bupivacaine
(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
(RS)-bupivacaine
1-Butyl-2',6'-pipecoloxylidide
1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide
1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide
15233-43-9
2180-92-9
38396-39-3
AB00053674
AC-2096
AC1L1DRE
AC1Q5LX4
AH 250
AKOS001637202
AR-1A0242
Anekain
BPBio1_000298
BRD-A01636364-003-05-2
BSPBio_000270
BSPBio_002607
Bio-0886
Bloqueina
Bucaine
Bucaine (TN)
Bupivacaina
Bupivacaina [INN-Spanish]
Bupivacaine
Bupivacaine (INN)
Bupivacaine Carbonate
Bupivacaine HCL
Bupivacaine HCL KIT
Bupivacaine Hydrochloride
Bupivacaine Monohydrochloride, Monohydrate
Bupivacaine [INN:BAN]
Bupivacainum
Bupivacainum [INN-Latin]
Bupivan
C07529
C18H28N2O
CBupivacaine
CHEBI:3215
CHEMBL1098
CID2474
Carbostesin
D07552
DB00297
DL-Bupivacaine
DUR-843
DepoBupivacaine
 
DivK1c_000758
EINECS 218-553-3
EINECS 253-911-2
Exparel
HMS2090F12
IDI1_000758
KBio1_000758
KBio2_002004
KBio2_004572
KBio2_007140
KBio3_001827
KBioGR_001516
KBioSS_002004
KST-1A4609
L000695
LAC-43
LS-109841
LS-2222
MLS001361336
Marcaina
Marcaine
Marcaine HCL
Marcaine Spinal
MolPort-004-955-820
NCGC00178579-01
NCGC00178579-02
NINDS_000758
NSC119660
Prestwick0_000305
Prestwick1_000305
Prestwick2_000305
Prestwick3_000305
Racemic bupivacaine
SMR000058218
SPBio_001558
SPBio_002489
Sensorcaine
Sensorcaine-MPF
Sensorcaine-MPF Spinal
Spectrum2_001589
Spectrum3_000974
Spectrum4_001098
Spectrum5_001483
Spectrum_001524
Transdur-Bupivacaine
UNII-Y8335394RO
Vivacaine
Win 11318
Win 11318 HCl
bupivacaine
cBupivacaine
dl-1-Butyl-2',6'-pipecoloxylidide
2
Dexamethasoneapproved, investigationalPhase 4190950-02-25743
Synonyms:
(3H)-Dexamethasone
.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol
.gamma.corten
1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone
1-Dehydro-16alpha -methyl-9alpha -fluorohydrocortisone
1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone
1-Dehydro-16α-methyl-9α-fluorohydrocortisone
137098-19-2
16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol
16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone
16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone
16-alpha-Methyl-9-alpha-fluoroprednisolone
16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol
16.alpha.-Methyl-9.alpha.-fluoroprednisolone
16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol
16alpha -Methyl-9alpha -fluoroprednisolone
16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol
16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone
16alpha-Methyl-9alpha-fluoroprednisolone
16α-Methyl-9α-fluoro-1-dehydrocortisol
23495-06-9
31375_FLUKA
46165_FLUKA
46165_RIEDEL
50-02-2
8054-59-9
9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9-Fluoro-11alpha -methylpregna-1,4-diene-3,20-dione
9-Fluoro-16-methylprednisolone
9-alpha-Fluoro-16-alpha-methylprednisolone
9.alpha.-Fluoro-16.alpha.-methylprednisolone
906422-84-2
9A-FLUORO-16BETA-METHYLPREDNISOLONE
9alpha -Fluoro-16alpha -methylprednisolone
9alpha-Fluoro-16alpha-methylprednisolone
9alpha-fluoro-16alpha-methyl-Prednisolone
9α-Fluoro-16α-methylprednisolone
AC-11056
AC1L1L1H
AC1Q29DM
AI3-50934
Adexone
Aeroseb-D
Aeroseb-Dex
Aeroseb-dex
Ak Dex Oph Otic Soln 0.1%
Alcon Brand of Dexamethasone
Anaflogistico
Aphtasolon
Aphthasolone
Apo-dexamethasone
Auxiron
Azimycin (veterinary)
Azium
Azium (Veterinary)
Azium (veterinary)
BIDD:ER0494
BIDD:PXR0060
BRD-K38775274-001-02-3
BRD-K38775274-001-06-4
BSPBio_000995
Baycadron
Bisu DS
Bisu Ds
C15643
C22H29FO5
CCRIS 7067
CHEBI:41879
CHEMBL384467
CID5743
CPD-10549
CPD001227192
Calonat
Corson
Corsone
Cortisumman
D00292
D003907
D1756_SIGMA
D4902_SIGMA
D6645_SIGMA
D8893_SIGMA
D9184_SIGMA
DB01234
DEX
DEXA
DEXONE 0.5
DEXONE 0.75
DEXONE 1.5
DEXONE 4
DXM
DXMS
Decacort
Decacortin
Decaderm
Decadron
Decadron (TN)
Decadron Tablets, Elixir
Decadron, Dexamethasone
Decadron-LA
Decadron-La
Decagel
Decaject
Decaject L.A.
Decaject-L.A.
Decalix
Decameth
Decasone
Decaspray
Dectancyl
Dekacort
Delta1-9alpha-Fluoro-16alpha-methylcortisol
Deltafluorene
Dergramin
Deronil
Desadrene
Desametasone
Desametasone [DCIT]
Desametasone [Dcit]
Desamethasone
Desameton
Deseronil
Dex-Ide
Dex-ide
Dexa
Dexa Mamallet
Dexa mamallet
Dexa-Cortidelt
Dexa-Cortisyl
Dexa-Mamallet
Dexa-Scheroson
Dexa-Sine
Dexa-cortidelt
Dexa-cortisyl
Dexa-scheroson
Dexa-sine
Dexacen-4
Dexacidin
Dexacort
Dexacortal
Dexacortin
Dexadeltone
Dexafarma
Dexair
Dexalona
Dexaltin
Dexametasona
Dexametasona [INN-Spanish]
Dexametasone
Dexameth
Dexamethansone
 
Dexamethasone
Dexamethasone (JP15/USP/INN)
Dexamethasone Acetate
Dexamethasone Alcohol
Dexamethasone Base
Dexamethasone Intensol
Dexamethasone Sodium Phosphate
Dexamethasone [INN:BAN:JAN]
Dexamethasone acetate
Dexamethasone alcohol
Dexamethasone base
Dexamethasone intensol
Dexamethasone sodium phosphate
Dexamethasone-omega
Dexamethasonum
Dexamethasonum [INN-Latin]
Dexamethazone
Dexamethsone
Dexamonozon
Dexapolcort
Dexapos
Dexaprol
Dexason
Dexasone
Dexasone 0.5mg
Dexasone 0.75mg
Dexasone 4mg
Dexasporin
Dexinolon
Dexinoral
Dexone
Dexone 0.5
Dexone 0.75
Dexone 1.5
Dexone 4
Dexonium
Dexpak
Dextelan
Dezone
Dinormon
Dxms
ECR Brand of Dexamethasone
EINECS 200-003-9
FT-0080377
Fluormethylprednisolone
Fluormone
Fluorocort
Fortecortin
Foy Brand of Dexamethasone
Gammacorten
HL-dex
HMS1792A17
HMS1990A17
HMS2089N13
HSDB 3053
Hexadecadrol
Hexadrol
Hexadrol Elixir
Hexadrol Tablets
Hexadrol elixir
Hl-Dex
Hl-dex
I06-1196
ICN Brand of Dexamethasone
IontoDex
Isopto-Dex
Isopto-dex
LS-7300
Lokalison F
Lokalison f
Loverine
Luxazone
MK 125
MLS001055412
MLS001332507
MLS001332508
Maxidex
Maxidex Ont 0.1%
Maxidex Sus 0.1%
Maxitrol
Mediamethasone
Merck Brand of Dexamethasone
Merz Brand 1 of Dexamethasone
Merz Brand 2 of Dexamethasone
Methylfluorprednisolone
Mexidex
Millicorten
MolMap_000018
MolPort-003-846-433
Mymethasone
NCGC00091019-01
NCGC00091019-02
NCGC00091019-03
NCGC00091019-04
NCGC00091019-05
NCI60_003067
NSC 34521
NSC34521
Naquasone (veterinary)
Neomycin and polymyxin b sulfates and dexamethasone
Neomycin and polymyxin b sulphates and dexamethasone
OTO-104
Ocu-Trol
Ocu-trol
Oradexon
Ozurdex
PHL-dexamethasone
PMS-dexamethasone
Pet Derm III
Pet Derm Iii
Pet derm III
Pet-Derm Iii
Pms Dexamethasone Elixir 0.5mg/5ml
Policort
Posurdex
Prednisolon F
Prednisolon f
Prednisolone F
Prednisolone f
Prodex
S1322_Selleck
SAM002548948
SGCUT00126
SK-Dexamethasone
SK-dexamethasone
SMP1_000092
SMR000857119
SMR001227192
ST50307091
Sandoz dexamethasone
Sk-Dexamethasone
Spectrum5_002019
Spoloven
Sunia Sol D
Sunia sol D
Superprednol
TL8003317
Tobradex
Tobramycin and dexamethasone
Tresaderm (veterinary)
Turbinaire
UNII-7S5I7G3JQL
Visumetazone
WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1
ZINC03875332
alpha -Fluoro-16-alpha -methylcortisol
delta(Sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol
delta1-9alpha-Fluoro-16alpha-methylcortisol
dexamethasone
nchembio809-comp2
to_000038
3AnestheticsPhase 47385
4HIV Protease InhibitorsPhase 44558
5Hormone AntagonistsPhase 410002
6HormonesPhase 411748
7Protease InhibitorsPhase 44558
8Peripheral Nervous System AgentsPhase 418510
9Hormones, Hormone Substitutes, and Hormone AntagonistsPhase 49988
10Gastrointestinal AgentsPhase 46401
11glucocorticoidsPhase 43896
12Anti-Inflammatory AgentsPhase 48478
13Dexamethasone acetatePhase 419091177-87-3
14Anesthetics, LocalPhase 42347
15Antineoplastic Agents, HormonalPhase 44256
16AntiemeticsPhase 43213
17BB 1101Phase 41909
18Dexamethasone 21-phosphatePhase 41909
19Central Nervous System DepressantsPhase 410016
20Immunologic FactorsPhase 218483
21Immunosuppressive AgentsPhase 210422
22Anti-Infective AgentsPhase 217220
23Angiogenesis Modulating AgentsPhase 23611
24Angiogenesis InhibitorsPhase 23688
25Anti-Bacterial AgentsPhase 29140

Interventional clinical trials:

idNameStatusNCT IDPhase
1Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb SurgeriesCompletedNCT02576782Phase 4
2Use of Thalidomide in Patients With ArachnoiditisCompletedNCT00284505Phase 2
3Study and Surgical Treatment of SyringomyeliaCompletedNCT00011245
4Spinal Cord Stimulation (SCS) Therapy StudyWithdrawnNCT02371122

Search NIH Clinical Center for Arachnoiditis


Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

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Anatomical Context for Arachnoiditis

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MalaCards organs/tissues related to Arachnoiditis:

33
Spinal cord, Brain, Bone, Heart, Lung, T cells, Eye

Animal Models for Arachnoiditis or affiliated genes

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Publications for Arachnoiditis

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Articles related to Arachnoiditis:

(show top 50)    (show all 1131)
idTitleAuthorsYear
1
Episodic Headache and Arachnoid Cyst Related Subdural Hematoma. (27197943)
2016
2
Prevalence and symptoms of intracranial arachnoid cysts: a population-based study. (26860092)
2016
3
Surgical management of intracranial arachnoid cysts: clinical and radiological outcome. (23546896)
2013
4
Arachnoiditis ossificans after revision adolescent idiopathic scoliosis surgery: a 22-year follow-up and review. (23722605)
2013
5
Endonasal management of sellar arachnoid cysts: simple cyst obliteration technique. (22283187)
2012
6
Spinal arachnoiditis and cyst formation with subarachnoid haemorrhage. (22299598)
2012
7
Should we resect all multiple intraspinal extradural arachnoid cysts? A case report. (22843467)
2012
8
Syringomyelia associated with arachnoid septum at the craniovertebral junction, contradicting the currently prevailing theory of syringomyelia formation. (22052474)
2012
9
Transient paraplegia after accidental insertion of an epidural catheter into an arachnoid cyst. (21897183)
2011
10
Cauda equina syndrome after spinal anaesthesia in a patient with asymptomatic tubercular arachnoiditis. (22013254)
2011
11
Endoscopic treatment of suprasellar arachnoid cysts in children. (21721882)
2011
12
Arachnoid cysts of the fourth ventricle - short illustrated review. (19387540)
2010
13
Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)
2010
14
Spinal cord compression caused by idiopathic intradural arachnoid cysts of the spine: review of the literature and illustrated case. (19763637)
2010
15
CSF overdrainage in shunted intracranial arachnoid cysts: a series and review. (19452154)
2009
16
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. (18400590)
2008
17
Adhesive arachnoiditis following percutaneous cervical cordotomy--may we still use lipiodol? (18823752)
2008
18
A case with giant arachnoid cysts manifested as migraine. (19116706)
2008
19
Intrasacral extradural arachnoid cysts. (18497497)
2008
20
Regression of syringomyelia and tonsillar herniation after posterior fossa arachnoid cyst excision. Case report and literature review. (17622461)
2007
21
Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. Case report and review of the literature. (16302620)
2005
22
Aneurysmal sub-arachnoid haemorrhage in patients with Noonan syndrome: a report of two cases and review of neurovascular presentations in this syndrome. (15034699)
2004
23
Neurologic deficits and arachnoiditis following neuroaxial anesthesia. (12492790)
2003
24
Do quiescent arachnoid cysts alter CNS functional organization?: A fMRI and morphometric study. (12499486)
2002
25
Arachnoiditis ossificans: MR imaging features in five patients. (11461883)
2001
26
A case report of caudal regression syndrome associated with an intraspinal arachnoid cyst. (10705931)
1999
27
Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. (9065498)
1997
28
Bilateral arachnoid cysts, seizures and severe encephalopathy: case report. (8208351)
1994
29
Nontraumatic intradiploic arachnoid cysts--report of five cases. (1282679)
1992
30
Endoscopic treatment of suprasellar arachnoid cysts. (1481755)
1992
31
Do arachnoid cysts grow? A retrospective CT volumetric study. (1922751)
1991
32
Intermittent downbeat nystagmus secondary to vermian arachnoid cyst with associated obstructive hydrocephalus. (1838553)
1991
33
A variant of the syndrome of spinal arachnoid cysts with multiple congenital defects. (2021437)
1991
34
Middle fossa arachnoid cysts. (2583835)
1989
35
MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. (2505512)
1989
36
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
37
Arachnoid cysts of the sylvian fissure. Evidence of fluid secretion. (6231356)
1984
38
Arachnoid cysts of the posterior fossa. Report of three cases. (6858736)
1983
39
Spinal intradural arachnoid cysts. (7110485)
1982
40
Multiple spinal arachnoid cysts: the role of oily contrast medium. (6264636)
1981
41
"Arachnoid cysts" of the sylvian fissure versus "temporal lobe agenesis" syndrome. (464549)
1979
42
Posterior fossa arachnoid cysts. (501222)
1979
43
The dysraphic state of the posterior fossa. Clinical review of the Dandy-Walker syndrome and the so-called arachnoid cysts. (536750)
1979
44
A clinical and radiological study of chronic lower spinal arachnoiditis. (1161142)
1975
45
Optochiasmatic arachnoiditis in multiple sclerosis. (1138685)
1975
46
Infratentorial arachnoid cysts. (4542573)
1973
47
Adhesive arachnoiditis after lumbar myelography with meglumine iothalamate (Conray). (5021465)
1972
48
Experimental studies of pantopaque arachnoiditis. 3. Clinical studies in progress. (5915430)
1966
49
Roentgen therapy in chronic spinal arachnoiditis. (13891940)
1962
50

Variations for Arachnoiditis

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Expression for genes affiliated with Arachnoiditis

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Search GEO for disease gene expression data for Arachnoiditis.

Pathways for genes affiliated with Arachnoiditis

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GO Terms for genes affiliated with Arachnoiditis

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Sources for Arachnoiditis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet