MCID: ARC002
MIFTS: 57

Arachnoiditis malady

Neuronal diseases category

Summaries for Arachnoiditis

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Sources:
42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord. the arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures. inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. arachnoiditis is difficult to treat and long-term outcomes are unpredictable. last updated: 2/12/2010

MalaCards: Arachnoiditis, also known as adhesive arachnoiditis, is related to meningioma and adenoma, and has symptoms including asthenia/fatigue/weakness, sphincter dysfunction and anomalies of ear and hearing. An important gene associated with Arachnoiditis is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)). The compounds gestrinone and triphenylethylene have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related mouse phenotypes are nervous system and reproductive system.

NINDS:43 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.

Wikipedia:63 Arachnoiditis is inflammation of the arachnoid, one of the membranes known as meninges that surround and... more...

Description from OMIM:46 182950

Aliases & Classifications for Arachnoiditis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 48Orphanet, 46OMIM, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
arachnoiditis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

arachnoiditis 8 42 43 48 46 60
adhesive arachnoiditis 48 60
chronic arachnoiditis 48
other meningitis nos 8
spinal arachnoiditis 42


External Ids:

Disease Ontology8 DOID:12156
NCIt39 C37913
MeSH34 D001100
SNOMED-CT via Orphanet57 8217007
UMLS via Orphanet61 C0003708
OMIM46 182950
MESH via Orphanet35 D001100

Related Diseases for Arachnoiditis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma30.6PGR, PTGDS
2adenoma30.0SSTR1, GH1, GNRH1
3pituitary adenoma29.9GNRH1, GH1, SSTR1
4syringomyelia10.7
5hydrocephalus10.5
6meningitis10.5
7arachnoid cysts10.5
8cervicitis10.4
9cauda equina syndrome10.3
10cerebritis10.3
11tibia absent polydactyly arachnoid cyst10.3
12ankylosing spondylitis10.3
13spondylitis10.3
14spinal intradural arachnoid cysts10.2
15communicating hydrocephalus10.2
16obstructive hydrocephalus10.1
17hypertension10.1
18intracranial hypertension10.1
19paraplegia10.1
20intracranial cysts10.1
21normal pressure hydrocephalus10.0
22choroiditis10.0
23intracranial hypotension10.0
24meningocele10.0
25spinal stenosis10.0
26trigeminal neuralgia10.0
27lymphedema10.0
28neuroma10.0
29optic nerve glioma10.0
30peritonitis10.0
31pituitary apoplexy10.0GNRH1
32endolymphatic hydrops10.0MIP
33hyperprolactinemia10.0GH1, GNRH1
34hypothalamic disease10.0GNRH1, GH1
35gonadal disease10.0GH1, GNRH1
36azoospermia10.0GNRH1, PTGDS
37obesity10.0MIP, GH1, FOXC2
38pituitary gland disease10.0GNRH1, GH1
39polycystic ovary syndrome10.0GH1, GNRH1
40gigantism10.0GH1
41pituitary tumors10.0SSTR1, GH1, GNRH1
42prolactinoma10.0SSTR1, GH1, GNRH1
43choriocarcinoma10.0GH1, GNRH1
44diabetes mellitus10.0GH1, FOXC2, DYT10
45acromegaly10.0SSTR1, GH1, GNRH1
46insulin resistance10.0MIP, GH1, FOXC2, DYT10
47foster-kennedy syndrome10.0
48dandy-walker syndrome10.0
49pseudotumor cerebri10.0
50sensorineural hearing loss10.0

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to arachnoiditis

Clinical Features for Arachnoiditis

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46OMIM, 48Orphanet
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Clinical features from OMIM:

182950

Clinical synopsis from OMIM:

182950

Symptoms:

48 (show all 16)
  • asthenia/fatigue/weakness
  • sphincter dysfunction
  • anomalies of ear and hearing
  • tinnitus
  • hearing loss/hypoacusia/deafness
  • meningitis/meningeal syndrome
  • motor deficit/trouble
  • areflexia/hyporeflexia
  • sensitive trouble/deficit
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • muscle weakness/flaccidity
  • articular/joint pain/arthralgia
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • hydrocephaly
  • facial pain/cephalalgia/migraine
  • anomalies of eyes and vision

Drugs & Therapeutics for Arachnoiditis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Arachnoiditis

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Anatomical Context for Arachnoiditis

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32MalaCards
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MalaCards organs/tissues related to Arachnoiditis:

32
Spinal cord, Brain, Temporal lobe, Eye, Pituitary, Skin, Testis, Bone, Spleen, Cingulate cortex, Cortex, Cerebellum, Endothelial, Testes, Kidney

Animal Models for Arachnoiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Arachnoiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.1GNRH1, FOXC2, CRLF1, GH1, SSTR1, MAP3K9
2MP:00053898.9SPAST, COL4A1, GNRH1, GH1, MAP3K9, RICTOR

Publications for Arachnoiditis

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50PubMed
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Articles related to Arachnoiditis:

(show top 50)    (show all 1035)
idTitleAuthorsYear
1
Arachnoiditis ossificans after revision adolescent idiopathic scoliosis surgery: a 22-year follow-up and review. (23722605)
2013
2
Cluster headache and arachnoid cyst. (23419954)
2013
3
An unresolved relationship--treated arachnoid cysts and idiopathic intracranial hypertension. (23333476)
2013
4
Intracranial arachnoid cysts: impairment of higher cognitive functions and postoperative improvement. (23985219)
2013
5
Arachnoiditis: are we accusing the wrong agent(s)? (23488838)
2013
6
Surgical management of an optic nerve glioma with perineural arachnoidal gliomatosis growth pattern. (23149617)
2013
7
Should we resect all multiple intraspinal extradural arachnoid cysts? A case report. (22843467)
2012
8
The specific sagittal magnetic resonance imaging of intradural extra-arachnoid lumbar disc herniation. (22431932)
2012
9
Tuberculous lumbar arachnoiditis mimicking conus cauda tumor: A case report and review of literature. (21716842)
2011
10
Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)
2010
11
Conversion disorder in a patient with posterior fossa arachnoid cyst. (20160225)
2010
12
Complications following large-volume epidural blood patches for postdural puncture headache. Lumbar subdural hematoma and arachnoiditis: initial cause or final effect? (19700281)
2009
13
Quadrigeminal arachnoid cysts in a kitten and a dog. (19737770)
2009
14
Nummular headache associated to arachnoid cysts. (19238510)
2009
15
Arachnoid cyst with growth hormone deficiency. (17401272)
2007
16
Intracystic pressure in patients with temporal arachnoid cysts: a prospective study of preoperative complaints and postoperative outcome. (17158556)
2007
17
Apparently novel genetic syndrome of pachygyria, mental retardation, seizure, and arachnoid cysts. (17343267)
2007
18
Multiple extradural arachnoid cysts: report of two operated cousin cases. (17873800)
2007
19
Post-lumbar puncture arachnoiditis. The need for directed questioning. (15797502)
2005
20
The treatment of large supratentorial arachnoid cysts in infants with cyst-peritoneal shunting and Hakim programmable valve. (12644868)
2003
21
Picture of the month. Diagnosis of arachnoid cysts. (10624002)
1999
22
Panhypopituitarism associated with diabetes insipidus in a girl with a suprasellar arachnoid cyst. (10640898)
1999
23
Dynamic CSF flow study in the pathophysiology of syringomyelia associated with arachnoid cysts of the posterior fossa. (11013645)
1998
24
Intracranial arachnoid cysts in children: related signs and associated anomalies. (9744627)
1998
25
Treatment of syringomyelia associated with arachnoid scarring caused by arachnoiditis or trauma. (9010425)
1997
26
Neurosurgical care of spinal epidural, subdural, and intramedullary abscesses and arachnoiditis. (8539043)
1996
27
Arachnoid cysts in adults: experience with internal shunts to the subdural compartment. (9190692)
1996
28
Arachnoid cysts of the left temporal fossa: impaired preoperative cognition and postoperative improvement. (7673959)
1995
29
Disappearance of arachnoid cysts after head injury. (7791985)
1995
30
Tuberculous radiculomyelitis (arachnoiditis): myelographic (and CT myelographic) appearances. (8147791)
1994
31
Syringomyelia as a complication of spinal arachnoiditis. (7855688)
1994
32
Transventricular endoscopic investigation and treatment of suprasellar arachnoid cysts. (1454143)
1992
33
Toward a rational therapeutic strategy for arachnoiditis. A possible role for d-penicillamine. (2011771)
1991
34
Intradural arachnoid cysts of the spinal canal associated with intramedullary cysts. (3280748)
1988
35
Ultrasound case of the day. Bilateral arachnoid cysts, diagnosed in utero. (3283870)
1988
36
MR imaging of lumbar arachnoiditis. (3499773)
1987
37
Diagnosis of perineurial arachnoid cysts using computed tomography: technical and clinical considerations. (3009674)
1986
38
Optochiasmatic arachnoiditis with treatment by surgical lysis of adhesions, corticosteroids, and cyclophosphamide: report of a case. (3748328)
1986
39
Steroid-induced arachnoiditis. (6700461)
1984
40
Relapsing polyradiculopathy in association with tubercular spinal meningitis (arachnoiditis). (7184930)
1982
41
Bacterial meningitis complicated by spinal arachnoiditis: diagnostic contribution of Tc-99m-inulin myeloscintigraphy. (7379425)
1980
42
Clinical analysis of arachnoid cysts in the middle fossa. (514432)
1979
43
Microsurgical intradural lysis and Silastic dural patch grafting in lumbar adhesive arachnoiditis. (534087)
1979
44
Arachnoid cysts of the middle cranial fossa. (1265637)
1976
45
Tuberculous arachnoiditis. (1111686)
1975
46
Experimental pantopaque arachnoiditis in the monkey. (4994136)
1971
47
Spinal arachnoiditis. (5709930)
1968
48
Tuberculous opticochiasmatic arachnoiditis; report of a case. (14851018)
1951
49
Optochiasmatic arachnoiditis. (20997753)
1946
50
Chiasmal Arachnoiditis. (19992601)
1943

Genetic Variations for Arachnoiditis

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Expression for genes affiliated with Arachnoiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arachnoiditis

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Pathways for genes affiliated with Arachnoiditis

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Compounds for genes affiliated with Arachnoiditis

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44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Arachnoiditis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1gestrinone4410.5GNRH1, PGR
2triphenylethylene4410.4DYT10, PGR
3estradiol benzoate4410.4PGR, GNRH1
4adenosine 3,5-cyclic monophosphorothioate4410.4DYT10, GNRH1
5nilutamide44 59 28 1113.4PGR, SACS, GNRH1
6leuprolide acetate4410.4GNRH1, GH1, PGR
7flutamide44 59 1112.4PGR, SACS, GNRH1
8clomiphene citrate4410.4PGR, GH1, GNRH1
9goserelin44 28 1112.4GNRH1, PGR
10progestins4410.4PGR, GH1, GNRH1
11raloxifene44 28 49 1113.4GNRH1, GH1, PGR
121-(5-isoquinolinylsulfonyl)-2-methylpiperazine4410.3GNRH1, DYT10
13allopregnanolone4410.3GNRH1, PGR
14octreotide44 59 28 1113.2GNRH1, GH1, SSTR1
15anastrozole44 1111.2PGR, GH1
16buserelin44 28 1112.2GNRH1, PGR
17estrone44 28 11 2413.1PGR, GH1, GNRH1
18gnrh4410.1PGR, GH1, DYT10, GNRH1
19ribonucleic acid4410.1GNRH1, GH1, SSTR1, PGR
20tamoxifen44 49 28 1113.0GNRH1, DYT10, GH1, PGR
21lanreotide44 2811.0GH1, SSTR1
22nifedipine44 49 28 1113.0GH1, DYT10, GNRH1
23testosterone44 59 11 2412.9PTGDS, PGR, GH1, SACS, GNRH1
24adenylate449.9PGR, SSTR1, GH1, DYT10, GNRH1
25verapamil44 49 28 11 2413.7GH1, DYT10, GNRH1

GO Terms for genes affiliated with Arachnoiditis

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Products for genes affiliated with Arachnoiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arachnoiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet