MCID: ARC002
MIFTS: 45

Arachnoiditis

Categories: Rare diseases, Genetic diseases, Neuronal diseases

Aliases & Classifications for Arachnoiditis

MalaCards integrated aliases for Arachnoiditis:

Name: Arachnoiditis 12 72 49 50 41 14 69
Familial Spinal Arachnoiditis 69
Spinal Arachnoiditis 49

Classifications:



Summaries for Arachnoiditis

NIH Rare Diseases : 49 Arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. The inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. It may result in scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. In some people. it may affect the bladder, bowel, and sexual function. Very severe arachnoiditis can result in paralysis of the legs. Treatment aims to relieve pain and improve symptoms that impair function. Treatment may include pain medications, physical therapy, and psychotherapy. Surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue. Last updated: 8/17/2016

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to meningocele and epidural abscess, and has symptoms including hydrocephalus, tinnitus and hearing impairment. An important gene associated with Arachnoiditis is TSHZ1 (Teashirt Zinc Finger Homeobox 1). The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

NINDS : 50 Arachnoiditis is caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including chronic and persistent pain,  numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 72 Arachnoiditis is an inflammatory condition of the arachnoid mater or \'arachnoid\', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 254)
# Related Disease Score Top Affiliating Genes
1 meningocele 29.3 C2 MNX1
2 epidural abscess 29.1 MNX1 MRI1
3 arachnoid cysts 12.6
4 spinal intradural arachnoid cysts 12.4
5 tibia absent polydactyly arachnoid cyst 12.3
6 spinal arachnoiditis 12.2
7 arachnoid cysts, intracranial 12.1
8 pachygyria with mental retardation, seizures, and arachnoid cysts 12.1
9 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 11.9
10 meningioma, familial 11.4
11 syringomyelia 11.4
12 intracranial cysts 11.4
13 melanosis, neurocutaneous 11.3
14 meningitis 11.2
15 chudley-mccullough syndrome 11.2
16 retrocerebellar cyst 10.9
17 amyloidosis, hereditary, transthyretin-related 10.8
18 polycystic kidney disease 1 10.8
19 syringomyelia, noncommunicating isolated 10.8
20 acrocallosal syndrome 10.8
21 encephalocraniocutaneous lipomatosis 10.8
22 hydrocephalus 10.3
23 aneurysm 10.1
24 tuberculous meningitis 10.1
25 cauda equina syndrome 10.1
26 cervicitis 10.1
27 cerebritis 10.0
28 headache 10.0
29 episodic pain syndrome, familial, 1 10.0
30 spondyloarthropathy 1 9.9
31 inflammatory spondylopathy 9.9
32 spondylitis 9.9
33 communicating hydrocephalus 9.9
34 epilepsy 9.9
35 obstructive hydrocephalus 9.8
36 intracranial hypertension 9.8
37 bobble-head doll syndrome 9.8
38 glioma 9.8
39 fibrosis of extraocular muscles, congenital, 1 9.8
40 trigeminal neuralgia 9.8
41 hydrocephalus, normal-pressure 9.8
42 cranial nerve palsy 9.8
43 craniopharyngioma 9.8
44 optic nerve glioma 9.8
45 paraplegia 9.8
46 syringohydromyelia 9.8
47 distichiasis 9.7
48 hydrocephalus, nonsyndromic, autosomal recessive 1 9.7
49 aging 9.7
50 hydrocephalus, nonsyndromic, autosomal recessive 2 9.7

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

31 (show all 13)
# Description HPO Frequency HPO Source Accession
1 hydrocephalus 31 occasional (7.5%) HP:0000238
2 tinnitus 31 hallmark (90%) HP:0000360
3 hearing impairment 31 hallmark (90%) HP:0000365
4 abnormality of vision 31 hallmark (90%) HP:0000504
5 anhidrosis 31 frequent (33%) HP:0000970
6 hyporeflexia 31 hallmark (90%) HP:0001265
7 meningitis 31 hallmark (90%) HP:0001287
8 muscle weakness 31 hallmark (90%) HP:0001324
9 migraine 31 occasional (7.5%) HP:0002076
10 arthralgia 31 hallmark (90%) HP:0002829
11 urinary bladder sphincter dysfunction 31 occasional (7.5%) HP:0002839
12 paresthesia 31 hallmark (90%) HP:0003401
13 fatigue 31 occasional (7.5%) HP:0012378

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 BB 1101 Phase 4
10 Central Nervous System Depressants Phase 4
11 Dexamethasone acetate Phase 4 1177-87-3
12 Gastrointestinal Agents Phase 4
13 glucocorticoids Phase 4
14 HIV Protease Inhibitors Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Peripheral Nervous System Agents Phase 4
19
protease inhibitors Phase 4
20
Busulfan Approved, Investigational Phase 2 55-98-1 2478
21
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
22
Carmustine Approved, Investigational Phase 2 154-93-8 2578
23
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
24
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
25
Etoposide Approved Phase 2 33419-42-0 36462
26
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 657311 5754
27
Ifosfamide Approved Phase 2 3778-73-2 3690
28
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
29
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
30
rituximab Approved Phase 2 174722-31-7 10201696
31 Thiotepa Approved, Investigational Phase 2 52-24-4 5453
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
34 Angiogenesis Inhibitors Phase 2
35 Angiogenesis Modulating Agents Phase 2
36 Anti-Bacterial Agents Phase 2
37 Anti-Infective Agents Phase 2
38 Immunosuppressive Agents Phase 2
39 Alkylating Agents Phase 2
40 Antimetabolites Phase 2
41 Antimetabolites, Antineoplastic Phase 2
42 Antineoplastic Agents, Phytogenic Phase 2
43 Antirheumatic Agents Phase 2
44 Antiviral Agents Phase 2
45 Cortisol succinate Phase 2
46 Dermatologic Agents Phase 2
47 Etoposide phosphate Phase 2
48 Folic Acid Antagonists Phase 2
49 Hydrocortisone 17-butyrate 21-propionate Phase 2
50 Hydrocortisone acetate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
5 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

38
Spinal Cord, Brain, Bone, Pituitary, Temporal Lobe, B Cells, Skin

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 1202)
# Title Authors Year
1
Development of Neuromyelitis Optica Spectrum Disorder and Spinal Arachnoid Cysts in a Patient With Intractable Epilepsy. ( 29379967 )
2018
2
The Transcondylar Approach to Access Symptomatic Arachnoid Cysts of the Hypoglossal Canal. ( 29351690 )
2018
3
Surgical management of cerebellopontine angle arachnoid cysts associated with hearing deficit in pediatric patients. ( 29171799 )
2018
4
Hemorrhagic complications of arachnoid cysts: When, Why and Who? ( 29410376 )
2018
5
The tethered effect of the arachnoid in vago-glossopharyngeal neuralgia: a real associated alternative mechanism? ( 29075903 )
2018
6
In Reply to the Letter to the Editor Regarding "Anatomic Dissection of Arachnoid Membranes Encircling the Pituitary Stalk on Fresh Non-Formalin-Fixed Specimens: Anatomoradiologic Correlations and Clinical Applications in Craniopharyngioma Surgery". ( 29232814 )
2018
7
Spinal adhesive arachnoiditis following the rupture of an Adamkiewicz aneurysm: Literature review and a case illustration. ( 29433818 )
2018
8
Spontaneous repeated disappearance and recurrence of multiple spinal intradural arachnoid cysts in a child. ( 29325964 )
2018
9
Case Report: Neurobrucellosis with Plastered Spinal Arachnoiditis: A Magnetic Resonance Imaging-Based Report. ( 29345223 )
2018
10
Temporal arachnoid cysts: are they congenital? ( 29046949 )
2018
11
Letter to the Editor Regarding "Anatomic Dissection of Arachnoid Membranes Encircling the Pituitary Stalk on Fresh Non-Formalin-Fixed Specimens: Anatomoradiologic Correlations and Clinical Applications in Craniopharyngioma Surgery". ( 29232813 )
2018
12
Long-term endocrine outcome of suprasellar arachnoid cysts. ( 28338427 )
2017
13
Idiopathic intradural dorsal thoracic arachnoid cysts: A case series and review of the literature. ( 28318981 )
2017
14
The association of arachnoid cysts and focal epilepsy: Hospital based case control study. ( 28527977 )
2017
15
Bobble-head doll syndrome in an 80-year-old man, associated with a giant arachnoid cyst of the lamina quadrigemina, treated with endoscopic ventriculocystocisternotomy and cystoperitoneal shunt. ( 28488069 )
2017
16
Clinical and Radiologic Outcomes After Fenestration and Partial Wall Excision of Idiopathic Intradural Spinal Arachnoid Cysts Presenting with Myelopathy. ( 28578118 )
2017
17
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )
2017
18
Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. ( 28639826 )
2017
19
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
20
Sonographic diagnosis and prognosis of fetal arachnoid cysts. ( 28984371 )
2017
21
Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )
2017
22
Antenatally diagnosed pre-pontine arachnoid cysts with significant post-natal supratentorial progression: report of two cases. ( 28918519 )
2017
23
Endoscopic surgery for intraventricular arachnoid cysts in children: clinical presentation, radiological features, management, and outcomes over a 12-year period. ( 28717832 )
2017
24
Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )
2017
25
Adhesive arachnoiditis secondary to the use of intrathecal liposoluble contrast. ( 29269177 )
2017
26
Differentiation of idiopathic spinal cord herniation from dorsal arachnoid webs on MRI and CT myelography. ( 28338452 )
2017
27
A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts. ( 28327950 )
2017
28
Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. ( 28761511 )
2017
29
Author response: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416620 )
2017
30
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
31
Management of quadrigeminal arachnoid cyst associated with obstructive hydrocephalus: report on stereotactic ventricular - cystic stenting. ( 28643523 )
2017
32
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
33
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
34
Arachnoid Cysts And Adult Onset Epilepsy. ( 28246242 )
2017
35
Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction. ( 28842236 )
2017
36
Recovery of Tinnitus and Sensorineural Hearing Loss Due to Lysis of Arachnoid Adhesions in the Posterior Cranial Fossa: Is There a Novel Etiology in Neurotological Disorders? ( 28816700 )
2017
37
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416621 )
2017
38
Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. ( 28704911 )
2017
39
Endoscopic treatment of middle fossa arachnoid cysts. ( 28905234 )
2017
40
Spinal arachnoid cysts - our experience and review of literature. ( 28287894 )
2017
41
The Significance of Arachnoid Granulation in Patients With Idiopathic Intracranial Hypertension. ( 28937488 )
2017
42
Arachnoiditis ossificans associated with syringomyelia: a case report. ( 29092643 )
2017
43
Conus Medullaris Arachnoid Cyst Presenting as Cauda Equina Syndrome. ( 29114289 )
2017
44
Anatomic dissection of arachnoid membranes encircling the pituitary stalk on fresh non formalin fixed specimens: anatomo-radiologic correlations and clinical applications in craniopharyngioma surgery. ( 28774763 )
2017
45
Does subjective improvement in adults with intracranial arachnoid cysts justify surgical treatment? ( 28298013 )
2017
46
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27379494 )
2016
47
Cervicothoracic intradural arachnoid cyst with scoliosis and brachial plexopathy. ( 26882854 )
2016
48
Comparative analysis of bleeding risk by the location and shape of arachnoid cysts: a finite element model analysis. ( 27718069 )
2016
49
A Case of Lumbosacral Arachnoiditis Ossificans. ( 28663987 )
2016
50
Radiological diagnosis of spinal arachnoid cysts: A pictorial essay. ( 27160059 )
2016

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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