MCID: ARC002
MIFTS: 44

Arachnoiditis malady

Rare diseases, Neuronal diseases categories
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Summaries for Arachnoiditis

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NIH Rare Diseases:42 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord. the arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures. inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. arachnoiditis is difficult to treat and long-term outcomes are unpredictable. last updated: 2/12/2010

MalaCards based summary: Arachnoiditis, also known as adhesive arachnoiditis, is related to arachnoid cysts and syringomyelia, and has symptoms including anomalies of eyes and vision, anomalies of ear and hearing and tinnitus. Affiliated tissues include spinal cord, brain and temporal lobe.

NINDS:43 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.

Wikipedia:65 Arachnoiditis is inflammation of the arachnoid, one of the membranes known as meninges that surround and... more...

Description from OMIM:46 182950

Aliases & Classifications for Arachnoiditis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 48Orphanet, 46OMIM, 62UMLS, 39NCIt, 57SNOMED-CT, 34MeSH, 35MESH via Orphanet, 63UMLS via Orphanet
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Arachnoiditis, Aliases & Descriptions:

Name: Arachnoiditis 8 42 43 48 46 62
Adhesive Arachnoiditis 48 62
Spinal Arachnoiditis 42 62
 
Chronic Arachnoiditis 48
Other Meningitis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
arachnoiditis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


External Ids:

Disease Ontology8 DOID:12156
NCIt39 C37913
MeSH34 D001100
OMIM46 182950
MESH via Orphanet35 D001100
UMLS via Orphanet63 C0003708

Related Diseases for Arachnoiditis

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Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to arachnoiditis

Symptoms for Arachnoiditis

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Symptoms by clinical synopsis from OMIM:

182950

Clinical features from OMIM:

182950

Symptoms:

48 (show all 16)
  • anomalies of eyes and vision
  • anomalies of ear and hearing
  • tinnitus
  • hearing loss/hypoacusia/deafness
  • meningitis/meningeal syndrome
  • motor deficit/trouble
  • areflexia/hyporeflexia
  • sensitive trouble/deficit
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • muscle weakness/flaccidity
  • articular/joint pain/arthralgia
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • hydrocephaly
  • facial pain/cephalalgia/migraine
  • sphincter dysfunction
  • asthenia/fatigue/weakness

HPO human phenotypes related to Arachnoiditis:

(show all 15)
id Description Frequency HPO Source Accession
1 tinnitus hallmark (90%) HP:0000360
2 hearing impairment hallmark (90%) HP:0000365
3 abnormality of the eye hallmark (90%) HP:0000478
4 meningitis hallmark (90%) HP:0001287
5 reduced tendon reflexes hallmark (90%) HP:0001315
6 muscle weakness hallmark (90%) HP:0001324
7 arthralgia hallmark (90%) HP:0002829
8 paresthesia hallmark (90%) HP:0003401
9 hypohidrosis typical (50%) HP:0000966
10 hydrocephalus occasional (7.5%) HP:0000238
11 migraine occasional (7.5%) HP:0002076
12 autosomal dominant inheritance HP:0000006
13 abnormality of the skeletal system HP:0000924
14 abnormality of metabolism/homeostasis HP:0001939
15 spastic paraparesis HP:0002313

Drugs & Therapeutics for Arachnoiditis

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Drug clinical trials:

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Search NIH Clinical Center for Arachnoiditis

Genetic Tests for Arachnoiditis

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Anatomical Context for Arachnoiditis

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MalaCards organs/tissues related to Arachnoiditis:

32
Spinal cord, Brain, Temporal lobe, Eye, Pituitary, Skin, Bone, Spleen, Cortex, Cerebellum, Kidney, Testis, Testes, Endothelial, Cingulate cortex

Animal Models for Arachnoiditis or affiliated genes

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Publications for Arachnoiditis

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Articles related to Arachnoiditis:

(show top 50)    (show all 1060)
idTitleAuthorsYear
1
Surgical management of intracranial arachnoid cysts: clinical and radiological outcome. (23546896)
2013
2
Arachnoiditis ossificans after revision adolescent idiopathic scoliosis surgery: a 22-year follow-up and review. (23722605)
2013
3
Endonasal management of sellar arachnoid cysts: simple cyst obliteration technique. (22283187)
2012
4
Spinal arachnoiditis and cyst formation with subarachnoid haemorrhage. (22299598)
2012
5
Should we resect all multiple intraspinal extradural arachnoid cysts? A case report. (22843467)
2012
6
Syringomyelia associated with arachnoid septum at the craniovertebral junction, contradicting the currently prevailing theory of syringomyelia formation. (22052474)
2012
7
Surgical management strategies of intracranial arachnoid cysts: a single institution experience of 75 cases. (23015336)
2012
8
Transient paraplegia after accidental insertion of an epidural catheter into an arachnoid cyst. (21897183)
2011
9
Cauda equina syndrome after spinal anaesthesia in a patient with asymptomatic tubercular arachnoiditis. (22013254)
2011
10
Endoscopic treatment of suprasellar arachnoid cysts in children. (21721882)
2011
11
Arachnoid cysts of the fourth ventricle - short illustrated review. (19387540)
2010
12
Use of the arachnoid membrane of the cerebellopontine angle to transpose the superior cerebellar artery in microvascular decompression for trigeminal neuralgia: technical note. (20173576)
2010
13
Spinal cord compression caused by idiopathic intradural arachnoid cysts of the spine: review of the literature and illustrated case. (19763637)
2010
14
Guidelines for the management of obstructive hydrocephalus from suprasellar-prepontine arachnoid cysts using endoscopic third ventriculocystocisternostomy. (20688773)
2010
15
Multiple extradural spinal arachnoid cysts: a case report and review of the literature. (19829999)
2009
16
Prenatal sonographic and magnetic resonance imaging demonstration of a right midline arachnoid cyst associated with ventriculomegaly, colpocephaly, dilation of the third ventricle, absence of cavum septi pellucidi, agenesis of the corpus callosum and mega cisterna magna. (18400590)
2008
17
Adhesive arachnoiditis following percutaneous cervical cordotomy--may we still use lipiodol? (18823752)
2008
18
A case with giant arachnoid cysts manifested as migraine. (19116706)
2008
19
Intrasacral extradural arachnoid cysts. (18497497)
2008
20
Regression of syringomyelia and tonsillar herniation after posterior fossa arachnoid cyst excision. Case report and literature review. (17622461)
2007
21
Pediatric orbital multifocal cavernous hemangiomas associated with bilateral arachnoid cysts of the middle cranial fossa. Case report and review of the literature. (16302620)
2005
22
Aneurysmal sub-arachnoid haemorrhage in patients with Noonan syndrome: a report of two cases and review of neurovascular presentations in this syndrome. (15034699)
2004
23
Neurologic deficits and arachnoiditis following neuroaxial anesthesia. (12492790)
2003
24
Do quiescent arachnoid cysts alter CNS functional organization?: A fMRI and morphometric study. (12499486)
2002
25
Syringomyelia associated with foramen magnum arachnoiditis. (12408385)
2002
26
Arachnoiditis ossificans: MR imaging features in five patients. (11461883)
2001
27
A case report of caudal regression syndrome associated with an intraspinal arachnoid cyst. (10705931)
1999
28
Prostaglandin D synthase (beta-trace) in human arachnoid and meningioma cells: roles as a cell marker or in cerebrospinal fluid absorption, tumorigenesis, and calcification process. (9065498)
1997
29
Expression of NF2 gene product merlin in arachnoid villi and meningiomas. (8958521)
1996
30
Bilateral arachnoid cysts, seizures and severe encephalopathy: case report. (8208351)
1994
31
Nontraumatic intradiploic arachnoid cysts--report of five cases. (1282679)
1992
32
Endoscopic treatment of suprasellar arachnoid cysts. (1481755)
1992
33
Do arachnoid cysts grow? A retrospective CT volumetric study. (1922751)
1991
34
Intermittent downbeat nystagmus secondary to vermian arachnoid cyst with associated obstructive hydrocephalus. (1838553)
1991
35
A variant of the syndrome of spinal arachnoid cysts with multiple congenital defects. (2021437)
1991
36
Middle fossa arachnoid cysts. (2583835)
1989
37
MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. (2505512)
1989
38
Outcome of implanted spinal cord stimulation in the treatment of chronic pain: arachnoiditis versus single nerve root injury and mononeuropathy. Brief clinical note. (2520402)
1989
39
Arachnoid cysts of the sylvian fissure. Evidence of fluid secretion. (6231356)
1984
40
Arachnoid cysts of the posterior fossa. Report of three cases. (6858736)
1983
41
Spinal intradural arachnoid cysts. (7110485)
1982
42
Multiple spinal arachnoid cysts: the role of oily contrast medium. (6264636)
1981
43
"Arachnoid cysts" of the sylvian fissure versus "temporal lobe agenesis" syndrome. (464549)
1979
44
Posterior fossa arachnoid cysts. (501222)
1979
45
A clinical and radiological study of chronic lower spinal arachnoiditis. (1161142)
1975
46
Optochiasmatic arachnoiditis in multiple sclerosis. (1138685)
1975
47
Infratentorial arachnoid cysts. (4542573)
1973
48
Adhesive arachnoiditis after lumbar myelography with meglumine iothalamate (Conray). (5021465)
1972
49
Experimental studies of pantopaque arachnoiditis. 3. Clinical studies in progress. (5915430)
1966
50
Roentgen therapy in chronic spinal arachnoiditis. (13891940)
1962

Variations for Arachnoiditis

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Expression for genes affiliated with Arachnoiditis

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Search GEO for disease gene expression data for Arachnoiditis.

Pathways for genes affiliated with Arachnoiditis

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Compounds for genes affiliated with Arachnoiditis

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GO Terms for genes affiliated with Arachnoiditis

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Products for genes affiliated with Arachnoiditis

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  • Antibodies
  • Proteins
  • Lysates

Sources for Arachnoiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet