MCID: ARC002
MIFTS: 57

Arachnoiditis malady

Neuronal diseases category

Summaries for Arachnoiditis

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Sources:
42NIH Rare Diseases, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord. the arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures. inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. arachnoiditis is difficult to treat and long-term outcomes are unpredictable. last updated: 2/12/2010

MalaCards: Arachnoiditis, also known as adhesive arachnoiditis, is related to meningioma and adenoma, and has symptoms including tinnitus, meningitis/meningeal syndrome and sphincter dysfunction. An important gene associated with Arachnoiditis is FOXC2 (forkhead box C2 (MFH-1, mesenchyme forkhead 1)). The compounds gestrinone and triphenylethylene have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and temporal lobe, and related mouse phenotypes are nervous system and reproductive system.

NINDS:43 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.

Wikipedia:63 Arachnoiditis is inflammation of the arachnoid, one of the membranes known as meninges that surround and... more...

Description from OMIM:46 182950

Aliases & Classifications for Arachnoiditis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 43NINDS, 48Orphanet, 46OMIM, 60UMLS, 39NCIt, 56SNOMED-CT, 34MeSH, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
arachnoiditis:
Inheritance: Sporadic; Age of onset: Variable; Age of death: Normal


Aliases & Descriptions:

arachnoiditis 8 42 43 48 46 60
adhesive arachnoiditis 48 60
chronic arachnoiditis 48
other meningitis nos 8
spinal arachnoiditis 42


External Ids:

Disease Ontology8 DOID:12156
NCIt39 C37913
MeSH34 D001100
SNOMED-CT via Orphanet57 8217007
UMLS via Orphanet61 C0003708
OMIM46 182950
MESH via Orphanet35 D001100

Related Diseases for Arachnoiditis

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17GeneCards, 18GeneDecks
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Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1meningioma30.6PGR, PTGDS
2adenoma30.0SSTR1, GH1, GNRH1
3pituitary adenoma29.9GNRH1, GH1, SSTR1
4syringomyelia10.7
5hydrocephalus10.5
6meningitis10.5
7arachnoid cysts10.5
8cervicitis10.4
9cauda equina syndrome10.3
10cerebritis10.3
11tibia absent polydactyly arachnoid cyst10.3
12ankylosing spondylitis10.3
13spondylitis10.3
14spinal intradural arachnoid cysts10.2
15communicating hydrocephalus10.2
16obstructive hydrocephalus10.1
17hypertension10.1
18intracranial hypertension10.1
19paraplegia10.1
20intracranial cysts10.1
21normal pressure hydrocephalus10.0
22choroiditis10.0
23intracranial hypotension10.0
24meningocele10.0
25spinal stenosis10.0
26trigeminal neuralgia10.0
27lymphedema10.0
28neuroma10.0
29optic nerve glioma10.0
30peritonitis10.0
31pituitary apoplexy10.0GNRH1
32endolymphatic hydrops10.0MIP
33hyperprolactinemia10.0GH1, GNRH1
34hypothalamic disease10.0GNRH1, GH1
35gonadal disease10.0GH1, GNRH1
36azoospermia10.0GNRH1, PTGDS
37obesity10.0MIP, GH1, FOXC2
38pituitary gland disease10.0GNRH1, GH1
39polycystic ovary syndrome10.0GH1, GNRH1
40gigantism10.0GH1
41pituitary tumors10.0SSTR1, GH1, GNRH1
42prolactinoma10.0SSTR1, GH1, GNRH1
43choriocarcinoma10.0GH1, GNRH1
44diabetes mellitus10.0GH1, FOXC2, DYT10
45acromegaly10.0SSTR1, GH1, GNRH1
46insulin resistance10.0MIP, GH1, FOXC2, DYT10
47foster-kennedy syndrome10.0
48dandy-walker syndrome10.0
49pseudotumor cerebri10.0
50sensorineural hearing loss10.0

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to arachnoiditis

Clinical Features for Arachnoiditis

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46OMIM, 48Orphanet
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Clinical features from OMIM:

182950

Clinical synopsis from OMIM:

182950

Symptoms:

48 (show all 16)
  • tinnitus
  • meningitis/meningeal syndrome
  • sphincter dysfunction
  • hydrocephaly
  • muscle weakness/flaccidity
  • hearing loss/hypoacusia/deafness
  • asthenia/fatigue/weakness
  • articular/joint pain/arthralgia
  • anomalies of eyes and vision
  • sensitive trouble/deficit
  • anomalies of ear and hearing
  • hypohidrosis/decreased sweating/thermoregulation disorder/heat intolerance
  • areflexia/hyporeflexia
  • facial pain/cephalalgia/migraine
  • paresthesia/dysesthesia/hypoesthesia/anesthesia/numbness
  • motor deficit/trouble

Drugs & Therapeutics for Arachnoiditis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Arachnoiditis

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Anatomical Context for Arachnoiditis

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32MalaCards
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MalaCards organs/tissues related to Arachnoiditis:

32
Spinal cord, Brain, Temporal lobe, Eye, Pituitary, Skin, Cingulate cortex, Bone, Kidney, Spleen, Cerebellum, Testis, Endothelial, Cortex, Testes

Animal Models for Arachnoiditis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Arachnoiditis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00036319.1GNRH1, FOXC2, CRLF1, GH1, SSTR1, MAP3K9
2MP:00053898.9SPAST, COL4A1, GNRH1, GH1, MAP3K9, RICTOR

Publications for Arachnoiditis

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50PubMed
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Articles related to Arachnoiditis:

(show top 50)    (show all 1035)
idTitleAuthorsYear
1
Benign extracerebral fluid collection in infancy as a risk factor for the development of de novo intracranial arachnoid cysts. (24093592)
2013
2
Aspergillus arachnoiditis post intrathecal baclofen pump insertion. (23685108)
2013
3
Multiple intracranial arachnoid cysts. (23198386)
2012
4
Intrapleural migration of a spinal catheter in a patient with arachnoiditis and extensive epidural scarring after tethered cord release: a case report and review of literature. (22329419)
2012
5
Extrapontine myelinolysis of osmotic demyelination syndrome in a case of postoperative suprasellar arachnoid cyst. (23326275)
2012
6
Complete resolution of medically refractory temporal lobe epilepsy after arachnoid cyst fenestration. (22649891)
2011
7
Arachnoid cysts of the fourth ventricle - short illustrated review. (19387540)
2010
8
Analysis of therapeutic choices for slit ventricle syndrome after cyst-peritoneal shunting for temporal arachnoid cysts in children. (21039172)
2010
9
Lumbar arachnoiditis and thecaloscopy: brief review and proposed treatment algorithm. (20027540)
2010
10
Nerve root prolapse into a spinal arachnoid cyst--an unusual cause of radiculopathy. (19185984)
2009
11
Treatment option for arachnoid cysts. (19536550)
2009
12
Delayed Medullar Syndrome after Aneurysmal Subarachnoid Haemorrhage. A Case report of Cystic Arachnoiditis! (20566150)
2007
13
Proteus syndrome with syringohydromyelia and arachnoid cyst. (17593376)
2007
14
Quadrigeminal cistern arachnoid cyst in a patient with Kabuki syndrome. (16765828)
2006
15
An unusual spinal arachnoiditis. (16257113)
2006
16
Thoracic arachnoiditis, arachnoid cyst and syrinx formation secondary to myelography with Myodil, 30 years previously. (16944225)
2006
17
Multiple extradural arachnoid cysts at the spinal cord and cauda equina levels in the young. (16010273)
2006
18
Clinical features and pathomechanisms of syringomyelia associated with spinal arachnoiditis. (15808720)
2005
19
Radiologic differentiation of intracranial epidermoids from arachnoid cysts. (11773853)
2002
20
Arachnoiditis ossificans of the cauda equina. Case report and review of the literature. (12296687)
2002
21
Lateral intrathoracic meningocele associated with a spinal intradural arachnoid cyst. (11549923)
2001
22
Endoscopic surgery for large posterior fossa arachnoid cysts. (11409307)
2001
23
Endoscopic treatment of prepontine arachnoid cysts. (11478058)
2001
24
The role of endoscopic fenestration procedures for cerebral arachnoid cysts. (10485626)
1999
25
Surgical management of symptomatic intrasellar arachnoid cysts--two case reports. (10658457)
1999
26
Paroxysmal kinesigenic choreoathetosis associated with frontotemporal arachnoid cyst--case report. (10193153)
1999
27
Middle cranial fossa arachnoid cysts: not always a benign entity. (9659139)
1998
28
Twins with different temporal lobe malformations: schizencephaly and arachnoid cyst. (10029345)
1998
29
MRI demonstration of arachnoiditis in cauda equina syndrome of ankylosing spondylitis. (8837094)
1996
30
Bilateral arachnoid cysts, seizures and severe encephalopathy: case report. (8208351)
1994
31
Pseudotumor syndrome in treated arachnoid cysts. (1394252)
1992
32
Hyaluronidase as an adjuvant in the management of tuberculous spinal arachnoiditis. (1856727)
1991
33
MR imaging of middle cranial fossa arachnoid cysts: temporal lobe agenesis syndrome revisited. (2505512)
1989
34
Magnetic resonance imaging of arachnoid cysts. (2598110)
1989
35
Arachnoid cysts: diagnosis and treatment. (2497116)
1989
36
Intrasellar arachnoid cysts. (3603351)
1987
37
Empty sella syndrome caused by syphilitic arachnoiditis. (3951113)
1986
38
Intrathecal hyaluronidase therapy in tuberculous spinal arachnoiditis. (3793698)
1986
39
Fluid secretion in arachnoid cysts as a clue to cerebrospinal fluid absorption at the arachnoid granulation. (3772452)
1986
40
Intravenous contrast-enhanced CT of the postoperative lumbar spine: improved identification of recurrent disk herniation, scar, arachnoiditis, and diskitis. (6332496)
1984
41
Arachnoid cysts--report of two adult cases in the interhemispheric fissure and over the cerebral convexity. (6176896)
1982
42
Intraspinal arachnoid cysts. (7102373)
1982
43
Microscopic lysis of lumbar adhesive arachnoiditis. (644390)
1978
44
Visual loss from optochiasmatic arachnoiditis after tuberculous meningitis. Case report. (845636)
1977
45
Arachnoiditis and VECP change. (1018222)
1976
46
Clinico-electroencephalographic correlations in patients with cerebral arachnoiditis. (4186763)
1969
47
The varying expressions of embryonal atresia of the fourth ventricle in adults: Arnold-Chiari malformation, Dandy-Walker syndrome, arachnoid cyst of the cerebellum, and syringomyelia. (13476218)
1957
48
Benign arachnoid cysts of the posterior fossa. (14946581)
1952
49
Optochiasmatic arachnoiditis; report of a case. (18143826)
1949
50
Etiology of optochiasmatic arachnoiditis. (18861099)
1948

Genetic Variations for Arachnoiditis

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Expression for genes affiliated with Arachnoiditis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arachnoiditis

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Pathways for genes affiliated with Arachnoiditis

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Compounds for genes affiliated with Arachnoiditis

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Sources:
44Novoseek, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Arachnoiditis according to GeneCards/GeneDecks:

(show all 25)
idCompoundScoreTop Affiliating Genes
1gestrinone4410.5GNRH1, PGR
2triphenylethylene4410.4DYT10, PGR
3estradiol benzoate4410.4PGR, GNRH1
4adenosine 3,5-cyclic monophosphorothioate4410.4DYT10, GNRH1
5nilutamide44 59 28 1113.4PGR, SACS, GNRH1
6leuprolide acetate4410.4GNRH1, GH1, PGR
7flutamide44 59 1112.4PGR, SACS, GNRH1
8clomiphene citrate4410.4PGR, GH1, GNRH1
9goserelin44 28 1112.4GNRH1, PGR
10progestins4410.4PGR, GH1, GNRH1
11raloxifene44 28 49 1113.4GNRH1, GH1, PGR
121-(5-isoquinolinylsulfonyl)-2-methylpiperazine4410.3GNRH1, DYT10
13allopregnanolone4410.3GNRH1, PGR
14octreotide44 59 28 1113.2GNRH1, GH1, SSTR1
15anastrozole44 1111.2PGR, GH1
16buserelin44 28 1112.2GNRH1, PGR
17estrone44 28 11 2413.1PGR, GH1, GNRH1
18gnrh4410.1PGR, GH1, DYT10, GNRH1
19ribonucleic acid4410.1GNRH1, GH1, SSTR1, PGR
20tamoxifen44 49 28 1113.0GNRH1, DYT10, GH1, PGR
21lanreotide44 2811.0GH1, SSTR1
22nifedipine44 49 28 1113.0GH1, DYT10, GNRH1
23testosterone44 59 11 2412.9PTGDS, PGR, GH1, SACS, GNRH1
24adenylate449.9PGR, SSTR1, GH1, DYT10, GNRH1
25verapamil44 49 28 11 2413.7GH1, DYT10, GNRH1

GO Terms for genes affiliated with Arachnoiditis

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Products for genes affiliated with Arachnoiditis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arachnoiditis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet