MCID: ARC002
MIFTS: 41

Arachnoiditis

Categories: Rare diseases, Neuronal diseases

Aliases & Classifications for Arachnoiditis

Summaries for Arachnoiditis

NIH Rare Diseases : 50 arachnoiditis is a pain disorder caused by inflammation of the arachnoid, one of the membranes that surrounds and protects the nerves of the spinal cord. the inflammation may occur due to irritation from chemicals; infection; direct injury to the spine; chronic compression of spinal nerves; or complications from spinal surgery or other spinal procedures. it may result in scar tissue and adhesions, which cause the spinal nerves to “stick” together. if arachnoiditis affects the function of nerves, it can cause symptoms such as numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs. in some people. it may affect the bladder, bowel, and sexual function. very severe arachnoiditis can result in paralysis of the legs. treatment aims to relieve pain and improve symptoms that impair function. treatment may include pain medications, physical therapy, and psychotherapy. surgical treatment is controversial because it offers only short-term relief and may increase formation of scar tissue. last updated: 8/17/2016

MalaCards based summary : Arachnoiditis, also known as familial spinal arachnoiditis, is related to arachnoid cysts and spinal intradural arachnoid cysts, and has symptoms including hyporeflexia, migraine and hydrocephalus. An important gene associated with Arachnoiditis is TSHZ1 (Teashirt Zinc Finger Homeobox 1). The drugs Bupivacaine and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and bone.

NINDS : 51 Arachnoiditis describes a pain disorder caused by the inflammation of the arachnoid, one of the membranes that surround and protect the nerves of the spinal cord.  The arachnoid can become inflamed because of an irritation from chemicals, infection from bacteria or viruses, as the result of direct injury to the spine, chronic compression of spinal nerves, or complications from spinal surgery or other invasive spinal procedures.  Inflammation can sometimes lead to the formation of scar tissue and adhesions, which cause the spinal nerves to “stick” together. If arachnoiditis begins to interfere with the function of one or more of these nerves, it can cause a number of symptoms, including numbness, tingling, and a characteristic stinging and burning pain in the lower back or legs.  Some people with arachnoiditis will have debilitating muscle cramps, twitches, or spasms.  It may also affect bladder, bowel, and sexual function.  In severe cases, arachnoiditis may cause paralysis of the lower limbs.

Wikipedia : 72 Arachnoiditis is an inflammatory condition of the arachnoid mater or \'arachnoid\', one of the membranes... more...

Related Diseases for Arachnoiditis

Diseases related to Arachnoiditis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 212)
id Related Disease Score Top Affiliating Genes
1 arachnoid cysts 12.5
2 spinal intradural arachnoid cysts 12.2
3 tibia absent polydactyly arachnoid cyst 12.1
4 spinal arachnoiditis 12.0
5 pachygyria with mental retardation, seizures, and arachnoid cysts 12.0
6 tibia, absence or hypoplasia of, with polydactyly, retrocerebellar arachnoid cyst, and other anomalies 11.8
7 syringomyelia 11.3
8 intracranial cysts 11.3
9 meningitis 11.1
10 chudley-mccullough syndrome 11.1
11 autosomal dominant polycystic kidney disease 11.0
12 meningioma, familial 11.0
13 neurocutaneous melanosis, somatic 10.9
14 retrocerebellar cyst 10.8
15 amyloidosis, hereditary, transthyretin-related 10.7
16 encephalocraniocutaneous lipomatosis 10.7
17 acrocallosal syndrome 10.7
18 hydrocephalus 10.2
19 aneurysm 10.0
20 tuberculous meningitis 10.0
21 cervicitis 10.0
22 cauda equina syndrome 9.9
23 cerebritis 9.9
24 headache 9.9
25 pulmonary edema 9.9 MNX1 MRI1
26 spondylitis 9.8
27 communicating hydrocephalus 9.8
28 epilepsy 9.8
29 intracranial hypertension 9.7
30 obstructive hydrocephalus 9.7
31 glioma 9.7
32 bobble-head doll syndrome 9.7
33 paraplegia 9.7
34 syringohydromyelia 9.7
35 cranial nerve palsy 9.7
36 normal pressure hydrocephalus 9.7
37 trigeminal neuralgia 9.7
38 optic nerve glioma 9.7
39 hand, foot and mouth disease 9.7 C2 MNX1
40 hemifacial spasm 9.6
41 lymphedema 9.6
42 neuroma 9.6
43 spasticity 9.6
44 meningocele 9.6
45 intracranial aneurysm 9.6
46 adenoma 9.6
47 radiculopathy 9.6
48 peritonitis 9.6
49 distichiasis 9.6
50 choroiditis 9.6

Graphical network of the top 20 diseases related to Arachnoiditis:



Diseases related to Arachnoiditis

Symptoms & Phenotypes for Arachnoiditis

Human phenotypes related to Arachnoiditis:

32 (show all 13)
id Description HPO Frequency HPO Source Accession
1 hyporeflexia 32 hallmark (90%) HP:0001265
2 migraine 32 occasional (7.5%) HP:0002076
3 hydrocephalus 32 occasional (7.5%) HP:0000238
4 anhidrosis 32 frequent (33%) HP:0000970
5 fatigue 32 occasional (7.5%) HP:0012378
6 muscle weakness 32 hallmark (90%) HP:0001324
7 tinnitus 32 hallmark (90%) HP:0000360
8 arthralgia 32 hallmark (90%) HP:0002829
9 hearing impairment 32 hallmark (90%) HP:0000365
10 meningitis 32 hallmark (90%) HP:0001287
11 paresthesia 32 hallmark (90%) HP:0003401
12 abnormality of vision 32 hallmark (90%) HP:0000504
13 urinary bladder sphincter dysfunction 32 occasional (7.5%) HP:0002839

Drugs & Therapeutics for Arachnoiditis

Drugs for Arachnoiditis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 56)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4 50-02-2 5743
3 Anesthetics Phase 4
4 Anesthetics, Local Phase 4
5 Antiemetics Phase 4
6 Anti-Inflammatory Agents Phase 4
7 Antineoplastic Agents, Hormonal Phase 4
8 Autonomic Agents Phase 4
9 BB 1101 Phase 4
10 Central Nervous System Depressants Phase 4
11 Dexamethasone acetate Phase 4 1177-87-3
12 Gastrointestinal Agents Phase 4
13 glucocorticoids Phase 4
14 HIV Protease Inhibitors Phase 4
15 Hormone Antagonists Phase 4
16 Hormones Phase 4
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
18 Peripheral Nervous System Agents Phase 4
19
protease inhibitors Phase 4
20
Busulfan Approved, Investigational Phase 2 55-98-1 2478
21
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
22
Carmustine Approved Phase 2 154-93-8 2578
23
Clonazepam Approved, Illicit Phase 2 1622-61-3 2802
24
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
25
Etoposide Approved Phase 2 33419-42-0 36462
26
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754 657311
27
Ifosfamide Approved Phase 2 3778-73-2 3690
28
Mechlorethamine Approved Phase 2 51-75-2 4033
29
Methotrexate Approved Phase 2 1959-05-2, 59-05-2 126941
30
rituximab Approved Phase 2 174722-31-7 10201696
31 Thiotepa Approved Phase 2 52-24-4 5453
32
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
33
leucovorin Approved, Nutraceutical Phase 2 58-05-9 143 6006
34 Angiogenesis Inhibitors Phase 2
35 Angiogenesis Modulating Agents Phase 2
36 Anti-Bacterial Agents Phase 2
37 Anti-Infective Agents Phase 2
38 Immunosuppressive Agents Phase 2
39 Alkylating Agents Phase 2
40 Antimetabolites Phase 2
41 Antimetabolites, Antineoplastic Phase 2
42 Antineoplastic Agents, Phytogenic Phase 2
43 Antirheumatic Agents Phase 2
44 Antiviral Agents Phase 2
45 Cortisol succinate Phase 2
46 Dermatologic Agents Phase 2
47 Etoposide phosphate Phase 2
48 Folic Acid Antagonists Phase 2
49 Hydrocortisone 17-butyrate 21-propionate Phase 2
50 Hydrocortisone acetate Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Dexamethasone & Bupivacaine vs Bupivacaine Alone in Combined Femoral and Sciatic Nerve Block for Perioperative Analgesia in Patients Undergoing Lower Limb Surgeries Completed NCT02576782 Phase 4 Perineural Dexamethasone and bupivacaine;Systemic Dexamethasone plus perineural bupivacaine;intravenous saline plus perineural bupivacaine
2 Use of Thalidomide in Patients With Arachnoiditis Completed NCT00284505 Phase 2 thalidomide
3 New Combination of Chemoimmunotherapy for Systemic B-cell Lymphoma With Central Nervous System Involvement Recruiting NCT02329080 Phase 2 Methotrexate;Rituximab;Cytarabine;Thiotepa;liposomial cytarabine;Etoposide;Ifosfamide;Carmustine
4 Study and Surgical Treatment of Syringomyelia Completed NCT00011245
5 Spinal Cord Stimulation (SCS) Therapy Study Withdrawn NCT02371122

Search NIH Clinical Center for Arachnoiditis

Cochrane evidence based reviews: arachnoiditis

Genetic Tests for Arachnoiditis

Anatomical Context for Arachnoiditis

MalaCards organs/tissues related to Arachnoiditis:

39
Spinal Cord, Brain, Bone, Temporal Lobe, Pituitary, B Cells, Skin

Publications for Arachnoiditis

Articles related to Arachnoiditis:

(show top 50) (show all 1184)
id Title Authors Year
1
Patterns of chronic inflammation in extensively treated patients with arachnoiditis and chronic intractable pain. ( 27929717 )
2017
2
Letter re: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416619 )
2017
3
Endoscopic treatment of middle fossa arachnoid cysts. ( 28905234 )
2017
4
Arachnoid Cysts And Adult Onset Epilepsy. ( 28246242 )
2017
5
Antenatally diagnosed pre-pontine arachnoid cysts with significant post-natal supratentorial progression: report of two cases. ( 28918519 )
2017
6
Spinal Arachnoiditis as a Complication of Cryptococcal Meningoencephalitis in Non-HIV Previously Healthy Adults. ( 28011613 )
2017
7
Clinical and Radiologic Outcomes After Fenestration and Partial Wall Excision of Idiopathic Intradural Spinal Arachnoid Cysts Presenting with Myelopathy. ( 28578118 )
2017
8
The association of arachnoid cysts and focal epilepsy: Hospital based case control study. ( 28527977 )
2017
9
Spinal arachnoid cysts - our experience and review of literature. ( 28287894 )
2017
10
Bobble-head doll syndrome in an 80-year-old man, associated with a giant arachnoid cyst of the lamina quadrigemina, treated with endoscopic ventriculocystocisternotomy and cystoperitoneal shunt. ( 28488069 )
2017
11
Late-Onset Non-HLH Presentations of Growth Arrest, Inflammatory Arachnoiditis, and Severe Infectious Mononucleosis, in Siblings with Hypomorphic Defects in UNC13D. ( 28848550 )
2017
12
Does subjective improvement in adults with intracranial arachnoid cysts justify surgical treatment? ( 28298013 )
2017
13
Management of quadrigeminal arachnoid cyst associated with obstructive hydrocephalus: report on stereotactic ventricular - cystic stenting. ( 28643523 )
2017
14
Intradural Extramedullary Capillary Hemangioma In the Upper Thoracic Spine with Simultaneous Extensive Arachnoiditis. ( 28704911 )
2017
15
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
16
Surgical Management of Syringomyelia Associated with Spinal Adhesive Arachnoiditis, a Late Complication of Tuberculous Meningitis: A Case Report. ( 28512616 )
2017
17
Anatomic dissection of arachnoid membranes encircling the pituitary stalk on fresh non formalin fixed specimens: anatomo-radiologic correlations and clinical applications in craniopharyngioma surgery. ( 28774763 )
2017
18
Endoscopic surgery for intraventricular arachnoid cysts in children: clinical presentation, radiological features, management, and outcomes over a 12-year period. ( 28717832 )
2017
19
Imaging Appearance of Advanced Chronic Adhesive Arachnoiditis: A Retrospective Review. ( 28639826 )
2017
20
Differentiation of idiopathic spinal cord herniation from dorsal arachnoid webs on MRI and CT myelography. ( 28338452 )
2017
21
The Significance of Arachnoid Granulation in Patients With Idiopathic Intracranial Hypertension. ( 28937488 )
2017
22
Author response: Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416620 )
2017
23
Idiopathic intradural dorsal thoracic arachnoid cysts: A case series and review of the literature. ( 28318981 )
2017
24
Recovery of Tinnitus and Sensorineural Hearing Loss Due to Lysis of Arachnoid Adhesions in the Posterior Cranial Fossa: Is There a Novel Etiology in Neurotological Disorders? ( 28816700 )
2017
25
Tuberculous optochiasmatic arachnoiditis and vision loss. ( 28416621 )
2017
26
Treatment of syringomyelia in patients with arachnoiditis at the cranio-cervical junction. ( 28842236 )
2017
27
A New Classification for Pathologies of Spinal Meninges-Part 2: Primary and Secondary Intradural Arachnoid Cysts. ( 28327950 )
2017
28
Long-term endocrine outcome of suprasellar arachnoid cysts. ( 28338427 )
2017
29
Intrathecal hematoma and arachnoiditis mimicking bacterial meningitis after an epidural blood patch. ( 28689621 )
2017
30
Genetic associations of intracranial aneurysm formation and sub-arachnoid hemorrhage. ( 28761511 )
2017
31
Supraorbital Keyhole Microsurgical Fenestration of Symptomatic Temporal Arachnoid Cysts in Children: Advantages and Limitations. ( 27873293 )
2016
32
Episodic Headache and Arachnoid Cyst Related Subdural Hematoma. ( 27197943 )
2016
33
Surgery for intracranial arachnoid cysts in children-a prospective long-term study. ( 27000761 )
2016
34
Motor Speech Apraxia in a 70-Year-Old Man with Left Dorsolateral Frontal Arachnoid Cyst: A [(18)F]FDG PET-CT Study. ( 28003922 )
2016
35
Adhesive arachnoiditis in mixed connective tissue disease: a rare neurological manifestation. ( 27986694 )
2016
36
Low-Cost Interactive Image-Based Virtual Endoscopy for the Diagnosis and Surgical Planning of Suprasellar Arachnoid Cysts. ( 26732948 )
2016
37
Intramedullary cyst formation after removal of multiple intradural spinal arachnoid cysts: A case report. ( 27512608 )
2016
38
Pediatric intraventricular arachnoid cysts in the body of lateral ventricle: surgical outcome and its embryologic background. ( 27492334 )
2016
39
The Acetazolamide Challenge: A Tool for Surgical Decision Making and Predicting Surgical Outcome in Patients with Arachnoid Cysts. ( 27415592 )
2016
40
Transsacrococcygeal approach to ganglion impar block for treatment of chronic coccygodynia after spinal arachnoid cyst removal: A case report. ( 27684866 )
2016
41
Retrocerebellar arachnoid cyst resulting in syringomyelia in a patient without tonsillar herniation: successful surgical treatment with reconstruction of CSF flow in the foramen magnum region. ( 26728365 )
2016
42
Treatment of Middle Cranial Fossa Arachnoid Cysts: A Systematic Review and Meta-Analysis. ( 27319312 )
2016
43
Acquired Chiari malformation secondary to tuberculous arachnoiditis of the lumbar spine. ( 27625266 )
2016
44
Arachnoid cyst: a further anomaly associated with Kallmann syndrome? ( 27379494 )
2016
45
Transfrontal Transaqueductal, Transtrigonal, and Suboccipital Infratentorial Supracerebellar Endoscopic Fenestration of Posterior Fossa Arachnoid Cysts: Three Surgical Cases. ( 26968147 )
2016
46
Sports participation with arachnoid cysts. ( 26636254 )
2016
47
Spinal extradural arachnoid cyst: A rare cause of neurogenic bladder. ( 27365974 )
2016
48
Digital Subtraction Cystography for Detection of Communicating Holes of Spinal Extradural Arachnoid Cysts. ( 26798223 )
2016
49
Assessment of endoscopic treatment for quadrigeminal cistern arachnoid cysts: A 7-year experience with 28 cases. ( 26590025 )
2016
50
Prevalence and symptoms of intracranial arachnoid cysts: a population-based study. ( 26860092 )
2016

Variations for Arachnoiditis

Expression for Arachnoiditis

Search GEO for disease gene expression data for Arachnoiditis.

Pathways for Arachnoiditis

GO Terms for Arachnoiditis

Sources for Arachnoiditis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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