MCID: ARG005
MIFTS: 38

Argyrophilic Grain Disease malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Argyrophilic Grain Disease

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Sources:
48Orphanet, 26ICD10 via Orphanet
See all sources

Aliases & Descriptions for Argyrophilic Grain Disease:

Name: Argyrophilic Grain Disease 48
 
Braak Disease 48


Classifications:



Characteristics (Orphanet epidemiological data):

48
argyrophilic grain disease:
Age of onset: Adult


External Ids:

Orphanet48 97342
ICD10 via Orphanet26 G31.8

Summaries for Argyrophilic Grain Disease

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Wikipedia:64 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

MalaCards based summary: Argyrophilic Grain Disease, also known as braak disease, is related to dementia and lateral sclerosis. An important gene associated with Argyrophilic Grain Disease is STH (saitohin), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Lipoprotein metabolism. The compounds memantine and tmao have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and cortex, and related mouse phenotypes are other and taste/olfaction.

Related Diseases for Argyrophilic Grain Disease

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Diseases related to Argyrophilic Grain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.0APOE, APP, MAPT
2lateral sclerosis30.8SNCA, MAPT
3tauopathy30.7APP, STH, SNCA, MAPT
4creutzfeldt-jakob disease29.8APOE, APP, SNCA, MAPT
5alzheimer disease28.9APOE, APP, STH, SNCA, MAPT, A2M
6neuronitis10.7
7semantic dementia10.5MAPT
8hereditary cerebral amyloid angiopathy10.4APP
9inclusion body myositis10.4APP
10schizophrenia10.3
11kuru10.3
12delusional disorder10.3
13aphasia10.2TARDBP, MAPT
14prion disease10.2MAPT, APP
15parkinson disease type 310.1MAPT, SNCA
16brain ischemia10.1MAPT, APP
17spinocerebellar ataxia10.1SNCA, MAPT
18movement disease10.1MAPT, SNCA
19central nervous system disease10.1MAPT, APP
20multiple system atrophy10.1SNCA, MAPT
21toxic encephalopathy10.1MAPT, APP
22binswanger's disease10.0APOE, APP
23alcohol dependence10.0MAPT, SNCA
24hemorrhage, intracerebral10.0APP, APOE
25niemann-pick disease, type c110.0APP, SNCA, MAPT
26motor neuron disease9.9TARDBP, MAPT, SNCA
27cerebrovascular disease9.9APP, APOE
28myositis9.9MAPT, SNCA, APP
29brain disease9.9APP, SNCA, MAPT
30teratocarcinoma9.9MAPT, SNCA, APP
31huntington disease9.9APP, SNCA, MAPT
32alzheimer disease-29.9APOE, APP, MAPT
33cerebral amyloid angiopathy9.9MAPT, APP, APOE
34nephrotic syndrome9.9A2M, APOE
35parkinson disease, late-onset9.8APOE, SNCA, MAPT
36amyotrophic lateral sclerosis 19.7APP, SNCA, MAPT, TARDBP
37malignant glioma9.7MAPT, SNCA, APP
38supranuclear palsy, progressive9.6MAPT, SNCA, APP, APOE
39dementia, lewy body9.6APOE, APP, SNCA, MAPT
40vascular dementia9.6APOE, APP, SNCA, MAPT
41amyloidosis9.6MAPT, SNCA, APP, APOE
42down syndrome9.6MAPT, SNCA, APP, APOE
43pick disease9.4APOE, APP, SNCA, MAPT, TARDBP
44dementia, frontotemporal9.2TARDBP, MAPT, SNCA, STH, APP, APOE

Graphical network of the top 20 diseases related to Argyrophilic Grain Disease:



Diseases related to argyrophilic grain disease

Symptoms for Argyrophilic Grain Disease

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Drugs & Therapeutics for Argyrophilic Grain Disease

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Drug clinical trials:

Search ClinicalTrials for Argyrophilic Grain Disease

Search NIH Clinical Center for Argyrophilic Grain Disease

Genetic Tests for Argyrophilic Grain Disease

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Anatomical Context for Argyrophilic Grain Disease

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MalaCards organs/tissues related to Argyrophilic Grain Disease:

31
Brain, Amygdala, Cortex, Hypothalamus, Subthalamic nucleus

Animal Models for Argyrophilic Grain Disease or affiliated genes

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MGI Mouse Phenotypes related to Argyrophilic Grain Disease:

35 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.9MAPT, APP, APOE
2MP:00053948.8APOE, SNCA, MAPT
3MP:00053698.3TARDBP, MAPT, APP, APOE
4MP:00030127.8TARDBP, MAPT, SNCA, APP, APOE
5MP:00107717.8APOE, APP, SNCA, MAPT
6MP:00053867.8APOE, APP, SNCA, MAPT, TARDBP
7MP:00053877.7TARDBP, MAPT, SNCA, APP, APOE
8MP:00053847.7APOE, APP, SNCA, MAPT, TARDBP
9MP:00036317.6APOE, APP, SNCA, MAPT, TARDBP
10MP:00107687.6TARDBP, MAPT, SNCA, APP, APOE
11MP:00053787.5APOE, APP, SNCA, MAPT, TARDBP

Publications for Argyrophilic Grain Disease

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Articles related to Argyrophilic Grain Disease:

(show top 50)    (show all 55)
idTitleAuthorsYear
1
Atypical sporadic CJD-MM phenotype with white matter kuru plaques associated with intranuclear inclusion body and argyrophilic grain disease. (25783686)
2015
2
Coexistence of mixed phenotype Creutzfeldt-Jakob disease, Lewy body disease and argyrophilic grain disease plus histological features of possible Alzheimer's disease: A multi-protein disorder in an autopsy case. (25186620)
2014
3
Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease. (24337498)
2014
4
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
5
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. (23371364)
2013
6
Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene. (24385851)
2013
7
Prominent psychiatric symptoms in patients with Parkinson's disease and concomitant argyrophilic grain disease. (24046066)
2013
8
Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis. (21702760)
2012
9
Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. (21157025)
2011
10
Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease. (21412174)
2011
11
Argyrophilic grain disease with delusions and hallucinations: a pathological study. (20738810)
2010
12
Neuropathological asymmetry in argyrophilic grain disease. (20535032)
2010
13
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease. (19039597)
2009
14
Tracing of temporo-entorhinal connections in the human brain: cognitively impaired argyrophilic grain disease cases show dendritic alterations but no axonal disconnection of temporo-entorhinal association neurons. (18075746)
2008
15
Argyrophilic grain disease. (18631777)
2008
16
Argyrophilic grain disease. (18234698)
2008
17
Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease. (17707587)
2007
18
Clinical characteristics of dementia associated with argyrophilic grain disease. (17693705)
2007
19
Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala. (18021374)
2007
20
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. (16783170)
2006
21
Argyrophilic grain disease: case report of the first two cases in the Czech Republic and review of the literature. (16715630)
2006
22
Argyrophilic grain disease: frequency and neuropathology in centenarians. (16525805)
2006
23
Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology. (16006341)
2005
24
The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology. (15885064)
2005
25
Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms. (16319301)
2005
26
Argyrophilic grain disease presenting with frontotemporal dementia: a neuropsychological and pathological study of an autopsied case with presenile onset. (15875911)
2005
27
Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. (15030402)
2004
28
Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. (15641585)
2004
29
Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease. (14517683)
2003
30
Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. (12580546)
2003
31
Argyrophilic grain disease: molecular genetic difference to other four-repeat tauopathies. (14513264)
2003
32
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes. (12175343)
2002
33
Pathological tau proteins in argyrophilic grain disease. (12849422)
2002
34
The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. (11849769)
2002
35
Argyrophilic grain disease is a sporadic 4-repeat tauopathy. (12071638)
2002
36
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. (12368187)
2002
37
Argyrophilic grain disease: neuropathology, frequency in a dementia brain bank and lack of relationship with apolipoprotein E. (11770901)
2002
38
Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. (12200631)
2002
39
Ballooned neurons in progressive supranuclear palsy are usually due to concurrent argyrophilic grain disease. (12070664)
2002
40
Argyrophilic grain disease mimicking temporal Pick's disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years. (11563637)
2001
41
Astrocytes expressing hyperphosphorylated tau protein without glial fibrillary tangles in argyrophilic grain disease. (10483782)
1999
42
Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease. (10476046)
1999
43
Dementia with grains (argyrophilic grain disease). (9546294)
1998
44
Ballooned neurons expressing alphaB-crystallin as a constant feature of the amygdala in argyrophilic grain disease. (9792618)
1998
45
Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria. (9869320)
1998
46
Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain disease. (9845289)
1998
47
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele. (9754952)
1998
48
Apolipoprotein E allele frequencies in argyrophilic grain disease. (9754953)
1998
49
Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. (9144586)
1997
50
Argyrophilic grain disease: distribution of grains in patients with and without dementia. (9341936)
1997

Variations for Argyrophilic Grain Disease

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Expression for genes affiliated with Argyrophilic Grain Disease

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Search GEO for disease gene expression data for Argyrophilic Grain Disease.

Pathways for genes affiliated with Argyrophilic Grain Disease

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Compounds for genes affiliated with Argyrophilic Grain Disease

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Compounds related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1memantine44 28 50 1112.9APP, MAPT
2tmao449.8MAPT, SNCA
3valproate449.8MAPT, APP
4methionine sulfoxide44 24 1111.7SNCA, APP
5metrifonate449.5APP, APOE
66-hydroxydopamine449.5SNCA, APP
724s-hydroxy-cholesterol449.5APP, APOE
8spec-t449.5MAPT, APOE
9guanidine44 24 1111.5APOE, MAPT
10atropine44 28 1111.4APP, SNCA
11silver449.4MAPT, SNCA
12c2ceramide449.4APP, MAPT
13thioflavin449.4SNCA, MAPT, APP
14carbachol44 28 1111.3APP, MAPT, SNCA
15choline44 24 1111.3APP, MAPT, SNCA
16vitamin b12449.2APOE, MAPT
17ibuprofen44 28 50 24 1113.2APOE, APP
18tacrine44 1110.2APOE, MAPT, APP
19donepezil44 50 24 1112.2APP, APOE, MAPT
20galantamine44 50 1111.1APP, MAPT, APOE
21chloroquine44 1 50 28 1113.1APP, MAPT, APOE
22folate449.1APOE, APP, MAPT
23nicotine44 28 50 1112.1MAPT, APP, APOE
24nmda44 2810.0APOE, MAPT, APP
25actinomycin d449.0APOE, APP, MAPT
26cyclosporin a44 28 6011.0APOE, APP, MAPT
27thioflavin t449.0SNCA, APP, APOE
28n acetylcysteine448.9APOE, MAPT, SNCA
29creatinine448.9MAPT, APP, APOE
30paraffin448.9APOE, MAPT, SNCA
31aspartate448.9MAPT, APP, APOE
32guanidine hydrochloride448.7SNCA, APOE
33thioflavine s448.6MAPT, APOE, APP, SNCA
34formate448.5APOE, APP, MAPT, SNCA
354-hydroxynonenal44 249.5SNCA, APP, APOE, MAPT
36lactacystin448.5MAPT, APOE, APP, SNCA
37sodium dodecylsulfate448.5APP, APOE, MAPT, SNCA
38valine448.5APOE, MAPT, APP, SNCA
39acetylcholine44 50 28 24 1112.5SNCA, APP, APOE, MAPT
40glutamine448.5APOE, APP, MAPT, SNCA
41dopamine44 28 24 1111.5APOE, SNCA, APP, MAPT
42h2o2448.5SNCA, APOE, APP, MAPT
43testosterone44 60 24 1111.5MAPT, SNCA, APOE, APP
44arginine448.4SNCA, APP, APOE, MAPT
45glutamate448.4APOE, MAPT, SNCA, APP
46alanine448.4APP, APOE, SNCA, MAPT
47cholesterol44 28 24 1111.4SNCA, APP, APOE, A2M
48cysteine448.4APP, SNCA, APOE, MAPT
49heparin44 28 24 1111.1A2M, APP, MAPT, APOE, SNCA
50serine448.0A2M, MAPT, APOE, APP, SNCA

GO Terms for genes affiliated with Argyrophilic Grain Disease

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Cellular components related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:00304269.4MAPT, SNCA
2platelet alpha granule lumenGO:00310939.4A2M, APP
3axonGO:00304248.9MAPT, SNCA, APP
4extracellular regionGO:00055767.8APOE, APP, SNCA, A2M

Biological processes related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:00080889.7MAPT, APP
2platelet degranulationGO:00025769.4A2M, APP
3adult locomotory behaviorGO:00083449.4SNCA, APP
4positive regulation of axon extensionGO:00457739.4MAPT, APOE
5negative regulation of endopeptidase activityGO:00109519.2A2M, APP
6cholesterol metabolic processGO:00082039.1APOE, APP
7agingGO:00075689.0SNCA, APOE

Molecular functions related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:00048679.5A2M, APP
2lipoprotein particle bindingGO:00718139.4MAPT, APOE
3tau protein bindingGO:00481569.0SNCA, APOE
4phospholipid bindingGO:00055438.7SNCA, APOE
5identical protein bindingGO:00428028.1APOE, APP, SNCA, TARDBP
6protein bindingGO:00055157.0APOE, APP, SNCA, MAPT, A2M, TARDBP

Sources for Argyrophilic Grain Disease

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet