MCID: ARG005
MIFTS: 33

Argyrophilic Grain Disease malady

Neuronal diseases, Rare diseases categories

Aliases & Classifications for Argyrophilic Grain Disease

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Sources:
51Orphanet, 28ICD10 via Orphanet
See all sources

Aliases & Descriptions for Argyrophilic Grain Disease:

Name: Argyrophilic Grain Disease 51
 
Braak Disease 51


Classifications:



Characteristics (Orphanet epidemiological data):

51
argyrophilic grain disease:
Age of onset: Adult


External Ids:

Orphanet51 97342
ICD10 via Orphanet28 G31.8

Summaries for Argyrophilic Grain Disease

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Wikipedia:68 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

MalaCards based summary: Argyrophilic Grain Disease, also known as braak disease, is related to alzheimer disease and dementia. An important gene associated with Argyrophilic Grain Disease is MAPT (Microtubule-Associated Protein Tau), and among its related pathways are Nongenotropic Androgen signaling and Nifedipine Activity. Affiliated tissues include brain, amygdala and subthalamic nucleus, and related mouse phenotypes are taste/olfaction and adipose tissue.

Related Diseases for Argyrophilic Grain Disease

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Diseases related to Argyrophilic Grain Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer disease28.8A2M, APOE, LRP1, MAPK1, MAPK8, MAPT
2dementia10.8
3neuronitis10.7
4tauopathy10.7
5lateral sclerosis10.4
6schizophrenia10.3
7creutzfeldt-jakob disease10.3
8kuru10.3
9delusional disorder10.3
10tumoral calcinosis10.2APOE, MAPT
11n-acetylglutamate synthase deficiency10.2MAPT, STH
12birdshot chorioretinopathy10.2APOE, MAPT
13lipoprotein glomerulopathy10.1APOE, MAPT
14teeth hard tissue disease10.1APOE, MAPT, STH
15gastrointestinal tularemia10.0MAPK1, MAPK8
16bradyopsia10.0MAPT, TARDBP
17hereditary angioedema10.0APOE, TARDBP
18corticosteroid-sensitive aseptic abscesses10.0MAPT, TARDBP
19carotid stenosis10.0MAPT, TARDBP
20bladder urachal squamous cell carcinoma10.0MAPT, TARDBP
21basophil adenoma10.0MAPT, TARDBP
22pigmentary cirrhosis9.9APOE, TARDBP
233mc syndrome9.9MAPT, TARDBP
24benign ependymoma9.9MAPT, TARDBP
25semmekrot haraldsson weemaes syndrome9.9APOE, MAPT, TARDBP
26dementia, lewy body9.9APOE, MAPT, TARDBP
27testicular leydig cell tumor9.9APOE, MAPT, TARDBP
28peripheral vascular disease9.9APOE, MAPT, TARDBP
29cardiomyopathy, dilated, 1u9.9APOE, MAPT, TARDBP
30demyelinating disease9.9APOE, MAPT, TARDBP
31mast syndrome9.8MAPT, TARDBP
32macular degeneration, age-related, 119.8A2M, APOE, LRP1, MAPT
33parkinson disease, late-onset9.8APOE, MAPK8, MAPT, STH
34central nervous system germ cell tumor9.8APOE, MAPT, TARDBP
35actinobacillosis9.8MAPT, TARDBP
36pick disease9.7APOE, MAPT, STH, TARDBP
37abri amyloidosis8.7A2M, APOE, LRP1, MAP2K1, MAPK1, MAPK8

Graphical network of the top 20 diseases related to Argyrophilic Grain Disease:



Diseases related to argyrophilic grain disease

Symptoms for Argyrophilic Grain Disease

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Drugs & Therapeutics for Argyrophilic Grain Disease

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Argyrophilic Grain Disease

Genetic Tests for Argyrophilic Grain Disease

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Anatomical Context for Argyrophilic Grain Disease

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MalaCards organs/tissues related to Argyrophilic Grain Disease:

33
Brain, Amygdala, Subthalamic nucleus, Hypothalamus, Cortex

Animal Models for Argyrophilic Grain Disease or affiliated genes

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MGI Mouse Phenotypes related to Argyrophilic Grain Disease:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000539410.0APOE, MAPK1, MAPT
2MP:00053758.6APOE, LRP1, MAPK8, TARDBP
3MP:00053697.7APOE, LRP1, MAPK1, MAPK8, MAPT, TARDBP
4MP:00053977.4APOE, LRP1, MAPK1, MAPK8, MAPT, TARDBP
5MP:00053787.3APOE, LRP1, MAP2K1, MAPK1, MAPK8, MAPT
6MP:00036317.2APOE, LRP1, MAP2K1, MAPK1, MAPK8, MAPT

Publications for Argyrophilic Grain Disease

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Articles related to Argyrophilic Grain Disease:

(show top 50)    (show all 56)
idTitleAuthorsYear
1
The Relationship Between Development of Neuronal and Astrocytic Tau Pathologies in Subcortical Nuclei and Progression of Argyrophilic Grain Disease. (26439704)
2015
2
Atypical sporadic CJD-MM phenotype with white matter kuru plaques associated with intranuclear inclusion body and argyrophilic grain disease. (25783686)
2015
3
Coexistence of mixed phenotype Creutzfeldt-Jakob disease, Lewy body disease and argyrophilic grain disease plus histological features of possible Alzheimer's disease: A multi-protein disorder in an autopsy case. (25186620)
2014
4
Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease. (24337498)
2014
5
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
6
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. (23371364)
2013
7
Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene. (24385851)
2013
8
Prominent psychiatric symptoms in patients with Parkinson's disease and concomitant argyrophilic grain disease. (24046066)
2013
9
Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis. (21702760)
2012
10
Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. (21157025)
2011
11
Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease. (21412174)
2011
12
Argyrophilic grain disease with delusions and hallucinations: a pathological study. (20738810)
2010
13
Neuropathological asymmetry in argyrophilic grain disease. (20535032)
2010
14
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease. (19039597)
2009
15
Tracing of temporo-entorhinal connections in the human brain: cognitively impaired argyrophilic grain disease cases show dendritic alterations but no axonal disconnection of temporo-entorhinal association neurons. (18075746)
2008
16
Argyrophilic grain disease. (18631777)
2008
17
Argyrophilic grain disease. (18234698)
2008
18
Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease. (17707587)
2007
19
Clinical characteristics of dementia associated with argyrophilic grain disease. (17693705)
2007
20
Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala. (18021374)
2007
21
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. (16783170)
2006
22
Argyrophilic grain disease: case report of the first two cases in the Czech Republic and review of the literature. (16715630)
2006
23
Argyrophilic grain disease: frequency and neuropathology in centenarians. (16525805)
2006
24
Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology. (16006341)
2005
25
The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology. (15885064)
2005
26
Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms. (16319301)
2005
27
Argyrophilic grain disease presenting with frontotemporal dementia: a neuropsychological and pathological study of an autopsied case with presenile onset. (15875911)
2005
28
Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. (15030402)
2004
29
Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. (15641585)
2004
30
Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease. (14517683)
2003
31
Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. (12580546)
2003
32
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes. (12175343)
2002
33
Pathological tau proteins in argyrophilic grain disease. (12849422)
2002
34
The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. (11849769)
2002
35
Argyrophilic grain disease is a sporadic 4-repeat tauopathy. (12071638)
2002
36
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. (12368187)
2002
37
Argyrophilic grain disease: neuropathology, frequency in a dementia brain bank and lack of relationship with apolipoprotein E. (11770901)
2002
38
Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. (12200631)
2002
39
Ballooned neurons in progressive supranuclear palsy are usually due to concurrent argyrophilic grain disease. (12070664)
2002
40
Argyrophilic grain disease mimicking temporal Pick's disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years. (11563637)
2001
41
Astrocytes expressing hyperphosphorylated tau protein without glial fibrillary tangles in argyrophilic grain disease. (10483782)
1999
42
Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease. (10476046)
1999
43
Dementia with grains (argyrophilic grain disease). (9546294)
1998
44
Ballooned neurons expressing alphaB-crystallin as a constant feature of the amygdala in argyrophilic grain disease. (9792618)
1998
45
Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria. (9869320)
1998
46
Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain disease. (9845289)
1998
47
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele. (9754952)
1998
48
Apolipoprotein E allele frequencies in argyrophilic grain disease. (9754953)
1998
49
Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. (9144586)
1997
50
Argyrophilic grain disease: distribution of grains in patients with and without dementia. (9341936)
1997

Variations for Argyrophilic Grain Disease

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Expression for genes affiliated with Argyrophilic Grain Disease

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Search GEO for disease gene expression data for Argyrophilic Grain Disease.

Pathways for genes affiliated with Argyrophilic Grain Disease

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Pathways related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5MAP2K1, MAPK1
29.5MAP2K1, MAPK1
39.5MAP2K1, MAPK1
49.5MAP2K1, MAPK1
59.5MAP2K1, MAPK1
69.3MAPK1, MAPK8
79.2APOE, MAPK8, MAPT
89.1A2M, APOE, LRP1
98.9MAP2K1, MAPK1, MAPK8
108.9MAP2K1, MAPK1, MAPK8
11
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
128.9MAP2K1, MAPK1, MAPK8
138.9MAP2K1, MAPK1, MAPK8
14
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
158.9MAP2K1, MAPK1, MAPK8
16
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
17
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
18
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
19
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
208.9MAP2K1, MAPK1, MAPK8
218.9MAP2K1, MAPK1, MAPK8
22
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
238.9MAP2K1, MAPK1, MAPK8
24
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
25
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
26
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
278.9MAP2K1, MAPK1, MAPK8
28
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
298.9MAP2K1, MAPK1, MAPK8
308.9MAP2K1, MAPK1, MAPK8
318.9MAP2K1, MAPK1, MAPK8
328.9MAP2K1, MAPK1, MAPK8
338.9MAP2K1, MAPK1, MAPK8
348.9MAP2K1, MAPK1, MAPK8
358.9MAP2K1, MAPK1, MAPK8
36
TGF-beta Signaling Pathway (sino)
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
378.9MAP2K1, MAPK1, MAPK8
388.9MAP2K1, MAPK1, MAPK8
39
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
40
VEGF Pathway (Tocris)
Show member pathways
8.9MAP2K1, MAPK1, MAPK8
418.9MAP2K1, MAPK1, MAPK8
42
Show member pathways
8.6MAP2K1, MAPK1, MAPK8, MAPT
43
Show member pathways
8.6MAP2K1, MAPK1, MAPK8, MAPT
448.6MAP2K1, MAPK1, MAPK8, MAPT
458.6MAP2K1, MAPK1, MAPK8, MAPT
468.6MAP2K1, MAPK1, MAPK8, MAPT
478.6MAP2K1, MAPK1, MAPK8, MAPT
48
Show member pathways
8.4LRP1, MAP2K1, MAPK1, MAPK8
498.3A2M, APOE, LRP1, MAPK1, MAPT
50
Show member pathways
8.1APOE, LRP1, MAPK1, MAPK8, MAPT

GO Terms for genes affiliated with Argyrophilic Grain Disease

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Cellular components related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dendrite cytoplasmGO:003283910.3MAP2K1, MAPK1
2early endosomeGO:00057699.5APOE, MAP2K1, MAPK1
3axonGO:00304249.5MAP2K1, MAPK1, MAPT
4dendriteGO:00304259.3APOE, LRP1, MAP2K1, MAPT
5cytoplasmGO:00057376.5APOE, LRP1, MAP2K1, MAPK1, MAPK8, MAPT

Biological processes related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

(show all 23)
idNameGO IDScoreTop Affiliating Genes
1trachea formationGO:006044010.2MAP2K1, MAPK1
2regulation of Golgi inheritanceGO:009017010.2MAP2K1, MAPK1
3regulation of stress-activated MAPK cascadeGO:003287210.2MAP2K1, MAPK1
4positive regulation of cholesterol effluxGO:001087510.2APOE, LRP1
5lipoprotein metabolic processGO:004215710.1APOE, LRP1
6regulation of early endosome to late endosome transportGO:200064110.1MAP2K1, MAPK1
7lung morphogenesisGO:006042510.1MAP2K1, MAPK1
8ERK1 and ERK2 cascadeGO:007037110.0MAP2K1, MAPK1
9regulation of sequence-specific DNA binding transcription factor activityGO:00510909.8MAPK1, MAPK8
10peptidyl-threonine phosphorylationGO:00181079.7MAPK1, MAPK8
11toll-like receptor signaling pathwayGO:00022249.2MAP2K1, MAPK1, MAPK8
12MyD88-dependent toll-like receptor signaling pathwayGO:00027559.2MAP2K1, MAPK1, MAPK8
13MyD88-independent toll-like receptor signaling pathwayGO:00027569.2MAP2K1, MAPK1, MAPK8
14toll-like receptor 2 signaling pathwayGO:00341349.1MAP2K1, MAPK1, MAPK8
15toll-like receptor 3 signaling pathwayGO:00341389.1MAP2K1, MAPK1, MAPK8
16toll-like receptor 4 signaling pathwayGO:00341429.1MAP2K1, MAPK1, MAPK8
17toll-like receptor 5 signaling pathwayGO:00341469.1MAP2K1, MAPK1, MAPK8
18toll-like receptor 9 signaling pathwayGO:00341629.0MAP2K1, MAPK1, MAPK8
19toll-like receptor 10 signaling pathwayGO:00341669.0MAP2K1, MAPK1, MAPK8
20TRIF-dependent toll-like receptor signaling pathwayGO:00356668.9MAP2K1, MAPK1, MAPK8
21stress-activated MAPK cascadeGO:00514038.9MAP2K1, MAPK1, MAPK8
22toll-like receptor TLR1:TLR2 signaling pathwayGO:00381238.8MAP2K1, MAPK1, MAPK8
23toll-like receptor TLR6:TLR2 signaling pathwayGO:00381248.6MAP2K1, MAPK1, MAPK8

Molecular functions related to Argyrophilic Grain Disease according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:00718139.8APOE, MAPT
2apolipoprotein bindingGO:00341859.5LRP1, MAPT
3MAP kinase activityGO:00047079.4MAPK1, MAPK8
4mitogen-activated protein kinase kinase kinase bindingGO:00314359.2MAP2K1, MAPK1

Sources for Argyrophilic Grain Disease

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet