MCID: ARG005
MIFTS: 43

Argyrophilic Grain Disease malady

Neuronal diseases, Rare diseases categories
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Summaries for Argyrophilic Grain Disease

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65Wikipedia, 33MalaCards
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Wikipedia:65 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

MalaCards: Argyrophilic Grain Disease, also known as braak disease, is related to tauopathy and dementia. An important gene associated with Argyrophilic Grain Disease is STH (saitohin), and among its related pathways are Response to elevated platelet cytosolic Ca2+ and Lipoprotein metabolism. The compounds memantine and tmao have been mentioned in the context of this disorder. Affiliated tissues include brain, amygdala and hypothalamus, and related mouse phenotypes are other and taste/olfaction.

Aliases & Classifications for Argyrophilic Grain Disease

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49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
argyrophilic grain disease:
Age of onset: Adulthood


Aliases & Descriptions:

argyrophilic grain disease 49
braak disease 49


External Ids:

ICD10 via Orphanet26 G31.8

Related Diseases for Argyrophilic Grain Disease

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17GeneCards, 18GeneDecks
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Diseases related to Argyrophilic Grain Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1tauopathy30.9APP, STH, SNCA, MAPT
2dementia30.8APOE, APP, STH, SNCA, MAPT, TARDBP
3alzheimer's disease30.7APOE, APP, STH, SNCA, MAPT, A2M
4lateral sclerosis30.6SNCA, MAPT
5parkinson's disease30.5APOE, SNCA, MAPT
6amyotrophic lateral sclerosis30.5APP, SNCA, MAPT, TARDBP
7progressive supranuclear palsy30.4MAPT, SNCA, APP, APOE
8pick's disease30.4APOE, APP, SNCA, MAPT, TARDBP
9frontotemporal dementia30.3TARDBP, MAPT, SNCA, STH, APP, APOE
10neuronitis10.6
11delusional disorder10.2
12schizophrenia10.2
13semantic dementia10.1MAPT
14hereditary cerebral amyloid angiopathy10.1APP
15inclusion body myositis10.1APP
16aphasia10.0TARDBP, MAPT
17prion disease10.0MAPT, APP
18parkinson disease type 310.0MAPT, SNCA
19brain ischemia10.0MAPT, APP
20spinocerebellar ataxia10.0SNCA, MAPT
21movement disease10.0MAPT, SNCA
22central nervous system disease10.0MAPT, APP
23multiple system atrophy10.0SNCA, MAPT
24stroke, hemorrhagic10.0APOE, APP
25binswanger's disease10.0APOE, APP
26toxic encephalopathy10.0MAPT, APP
27hemorrhage, intracerebral10.0APP, APOE
28niemann-pick disease10.0APP, SNCA, MAPT
29motor neuron disease10.0TARDBP, MAPT, SNCA
30myositis10.0MAPT, SNCA, APP
31brain disease10.0APP, SNCA, MAPT
32teratocarcinoma10.0MAPT, SNCA, APP
33cerebrovascular disease10.0APP, APOE
34huntington's disease10.0APP, SNCA, MAPT
35alzheimer disease type 210.0APOE, APP, MAPT
36cerebral amyloid angiopathy10.0MAPT, APP, APOE
37amyloid tumor10.0MAPT, APP, APOE
38malignant glioma9.9MAPT, SNCA, APP
39nephrotic syndrome9.9A2M, APOE
40lewy body dementia9.9APOE, APP, SNCA, MAPT
41vascular dementia9.9APOE, APP, SNCA, MAPT
42creutzfeldt-jakob disease9.9APOE, APP, SNCA, MAPT
43memory impairment9.9APOE, APP, SNCA, MAPT
44amyloidosis9.9MAPT, SNCA, APP, APOE
45down syndrome9.9MAPT, SNCA, APP, APOE

Graphical network of the top 20 diseases related to Argyrophilic Grain Disease:



Diseases related to argyrophilic grain disease

Symptoms for Argyrophilic Grain Disease

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Drugs & Therapeutics for Argyrophilic Grain Disease

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Sources:
42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Argyrophilic Grain Disease

Search NIH Clinical Center for Argyrophilic Grain Disease

Genetic Tests for Argyrophilic Grain Disease

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Anatomical Context for Argyrophilic Grain Disease

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33MalaCards
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MalaCards organs/tissues related to Argyrophilic Grain Disease:

33
Brain, Amygdala, Hypothalamus, Cortex, Subthalamic nucleus

Animal Models for Argyrophilic Grain Disease or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Argyrophilic Grain Disease:

37 (show all 11)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053958.9MAPT, APP, APOE
2MP:00053948.8APOE, SNCA, MAPT
3MP:00053698.3TARDBP, MAPT, APP, APOE
4MP:00030127.8TARDBP, MAPT, SNCA, APP, APOE
5MP:00107717.8APOE, APP, SNCA, MAPT
6MP:00053867.8APOE, APP, SNCA, MAPT, TARDBP
7MP:00053877.7TARDBP, MAPT, SNCA, APP, APOE
8MP:00053847.7APOE, APP, SNCA, MAPT, TARDBP
9MP:00036317.6APOE, APP, SNCA, MAPT, TARDBP
10MP:00107687.6TARDBP, MAPT, SNCA, APP, APOE
11MP:00053787.5APOE, APP, SNCA, MAPT, TARDBP

Publications for Argyrophilic Grain Disease

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52PubMed
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Articles related to Argyrophilic Grain Disease:

(show top 50)    (show all 53)
idTitleAuthorsYear
1
Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease. (24337498)
2014
2
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
3
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. (23371364)
2013
4
Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene. (24385851)
2013
5
Prominent psychiatric symptoms in patients with Parkinson's disease and concomitant argyrophilic grain disease. (24046066)
2013
6
Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis. (21702760)
2012
7
Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. (21157025)
2011
8
Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease. (21412174)
2011
9
Argyrophilic grain disease with delusions and hallucinations: a pathological study. (20738810)
2010
10
Neuropathological asymmetry in argyrophilic grain disease. (20535032)
2010
11
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease. (19039597)
2009
12
Tracing of temporo-entorhinal connections in the human brain: cognitively impaired argyrophilic grain disease cases show dendritic alterations but no axonal disconnection of temporo-entorhinal association neurons. (18075746)
2008
13
Argyrophilic grain disease. (18631777)
2008
14
Argyrophilic grain disease. (18234698)
2008
15
Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease. (17707587)
2007
16
Clinical characteristics of dementia associated with argyrophilic grain disease. (17693705)
2007
17
Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala. (18021374)
2007
18
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. (16783170)
2006
19
Argyrophilic grain disease: case report of the first two cases in the Czech Republic and review of the literature. (16715630)
2006
20
Argyrophilic grain disease: frequency and neuropathology in centenarians. (16525805)
2006
21
Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology. (16006341)
2005
22
The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology. (15885064)
2005
23
Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms. (16319301)
2005
24
Argyrophilic grain disease presenting with frontotemporal dementia: a neuropsychological and pathological study of an autopsied case with presenile onset. (15875911)
2005
25
Increased frequency of argyrophilic grain disease in Alzheimer disease with 4R tau-specific immunohistochemistry. (15804052)
2005
26
Molecular evolution and genetics of the Saitohin gene and tau haplotype in Alzheimer's disease and argyrophilic grain disease. (15030402)
2004
27
Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. (15641585)
2004
28
Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease. (14517683)
2003
29
Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. (12580546)
2003
30
Argyrophilic grain disease: molecular genetic difference to other four-repeat tauopathies. (14513264)
2003
31
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes. (12175343)
2002
32
Pathological tau proteins in argyrophilic grain disease. (12849422)
2002
33
The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. (11849769)
2002
34
Argyrophilic grain disease is a sporadic 4-repeat tauopathy. (12071638)
2002
35
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. (12368187)
2002
36
Argyrophilic grain disease: neuropathology, frequency in a dementia brain bank and lack of relationship with apolipoprotein E. (11770901)
2002
37
Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. (12200631)
2002
38
Ballooned neurons in progressive supranuclear palsy are usually due to concurrent argyrophilic grain disease. (12070664)
2002
39
Argyrophilic grain disease mimicking temporal Pick's disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years. (11563637)
2001
40
Argyrophilic grain disease. A frequent dementing disorder in aged patients. (11403164)
2001
41
Astrocytes expressing hyperphosphorylated tau protein without glial fibrillary tangles in argyrophilic grain disease. (10483782)
1999
42
Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease. (10476046)
1999
43
Dementia with grains (argyrophilic grain disease). (9546294)
1998
44
Ballooned neurons expressing alphaB-crystallin as a constant feature of the amygdala in argyrophilic grain disease. (9792618)
1998
45
Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria. (9869320)
1998
46
Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain disease. (9845289)
1998
47
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele. (9754952)
1998
48
Apolipoprotein E allele frequencies in argyrophilic grain disease. (9754953)
1998
49
Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. (9144586)
1997
50
Argyrophilic grain disease: distribution of grains in patients with and without dementia. (9341936)
1997

Variations for Argyrophilic Grain Disease

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Expression for genes affiliated with Argyrophilic Grain Disease

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Argyrophilic Grain Disease

Search GEO for disease gene expression data for Argyrophilic Grain Disease.

Pathways for genes affiliated with Argyrophilic Grain Disease

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Sources:
50PathCards, 55Reactome, 53QIAGEN, 54R&D Systems, 30KEGG, 38NCBI BioSystems Database, 5Cell Signaling Technology
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Compounds for genes affiliated with Argyrophilic Grain Disease

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45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB, 61Tocris Bioscience
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Compounds related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

(show top 50)    (show all 54)
idCompoundScoreTop Affiliating Genes
1memantine45 29 51 1112.9MAPT, APP
2tmao459.8SNCA, MAPT
3valproate459.8MAPT, APP
4methionine sulfoxide45 24 1111.7SNCA, APP
5metrifonate459.5APOE, APP
66-hydroxydopamine459.5APP, SNCA
724s-hydroxy-cholesterol459.5APP, APOE
8spec-t459.5APOE, MAPT
9guanidine45 24 1111.5APOE, MAPT
10c2ceramide459.4MAPT, APP
11atropine45 29 1111.4SNCA, APP
12silver459.4MAPT, SNCA
13thioflavin459.4MAPT, SNCA, APP
14carbachol45 29 1111.3MAPT, SNCA, APP
15vitamin b12459.3APOE, MAPT
16choline45 24 1111.3APP, SNCA, MAPT
17tacrine45 1110.2APOE, APP, MAPT
18donepezil45 51 24 1112.2MAPT, APP, APOE
19galantamine45 51 1111.1APOE, APP, MAPT
20chloroquine45 3 51 29 1113.1MAPT, APP, APOE
21ibuprofen45 29 51 24 1113.1APOE, APP
22folate459.1APOE, APP, MAPT
23nicotine45 29 51 1112.1MAPT, APP, APOE
24nmda45 2910.0MAPT, APP, APOE
25actinomycin d459.0APOE, APP, MAPT
26cyclosporin a45 29 6111.0APOE, APP, MAPT
27thioflavin t459.0SNCA, APP, APOE
28n acetylcysteine458.9MAPT, SNCA, APOE
29creatinine458.9MAPT, APP, APOE
30paraffin458.9MAPT, SNCA, APOE
31aspartate458.9APOE, APP, MAPT
32guanidine hydrochloride458.7SNCA, APOE
33thioflavine s458.6MAPT, SNCA, APP, APOE
34formate458.5APOE, APP, SNCA, MAPT
354-hydroxynonenal45 249.5APOE, APP, SNCA, MAPT
36lactacystin458.5APOE, APP, SNCA, MAPT
37sodium dodecylsulfate458.5APOE, APP, SNCA, MAPT
38valine458.5MAPT, SNCA, APP, APOE
39acetylcholine45 51 29 24 1112.5APOE, APP, SNCA, MAPT
40glutamine458.5APOE, APP, SNCA, MAPT
41dopamine45 29 24 1111.5APOE, APP, SNCA, MAPT
42h2o2458.5APOE, APP, SNCA, MAPT
43testosterone45 61 24 1111.5APOE, APP, SNCA, MAPT
44arginine458.4APOE, APP, SNCA, MAPT
45glutamate458.4APOE, APP, SNCA, MAPT
46alanine458.4APOE, APP, SNCA, MAPT
47cholesterol45 29 24 1111.4A2M, SNCA, APP, APOE
48cysteine458.4APOE, APP, SNCA, MAPT
49heparin45 29 24 1111.1A2M, MAPT, SNCA, APP, APOE
50serine458.0APOE, APP, SNCA, MAPT, A2M

GO Terms for genes affiliated with Argyrophilic Grain Disease

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16Gene Ontology
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Cellular components related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth coneGO:0304269.4MAPT, SNCA
2platelet alpha granule lumenGO:0310939.4A2M, APP
3axonGO:0304248.9MAPT, SNCA, APP
4extracellular regionGO:0055767.8APOE, APP, SNCA, A2M

Biological processes related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:0080889.7MAPT, APP
2platelet degranulationGO:0025769.4A2M, APP
3adult locomotory behaviorGO:0083449.4SNCA, APP
4positive regulation of axon extensionGO:0457739.4MAPT, APOE
5negative regulation of endopeptidase activityGO:0109519.2A2M, APP
6cholesterol metabolic processGO:0082039.1APOE, APP
7agingGO:0075689.0SNCA, APOE

Molecular functions related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serine-type endopeptidase inhibitor activityGO:0048679.5APP, A2M
2lipoprotein particle bindingGO:0718139.4APOE, MAPT
3tau protein bindingGO:0481569.0APOE, SNCA
4phospholipid bindingGO:0055438.7APOE, SNCA
5identical protein bindingGO:0428028.1APP, SNCA, TARDBP, APOE
6protein bindingGO:0055157.0APP, SNCA, MAPT, A2M, TARDBP, APOE

Products for genes affiliated with Argyrophilic Grain Disease

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Sources for Argyrophilic Grain Disease

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet