MCID: ARG005
MIFTS: 36

Argyrophilic Grain Disease malady

Neuronal category

Summaries for Argyrophilic Grain Disease

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

MalaCards: Argyrophilic Grain Disease, also known as braak disease, is related to alzheimer's disease and brain disease. An important gene associated with Argyrophilic Grain Disease is STH (saitohin), and among its related pathways are Reelin Pathway (Cajal-Retzius cells) and A-beta Uptake & Degradation. The compounds cyclosporin a and memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and hypothalamus, and related mouse phenotypes are taste/olfaction and other.

Aliases & Classifications for Argyrophilic Grain Disease

Sources:
49Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Characteristics (Orphanet epidemiological data):

49
argyrophilic grain disease:
Age of onset: Adulthood


Aliases & Descriptions:

argyrophilic grain disease 49
braak disease 49


External Ids:

ICD10 via Orphanet26 G31.8

Related Diseases for Argyrophilic Grain Disease

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Argyrophilic Grain Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 53)
idRelated DiseaseScoreTop Affiliating Genes
1alzheimer's disease30.8APP, APOE, A2M, STH, SNCA, MAPT
2brain disease30.7APP, SNCA, MAPT
3tauopathy30.7APP, STH, SNCA, MAPT
4lateral sclerosis30.6SNCA, MAPT
5amyotrophic lateral sclerosis30.6APP, SNCA, MAPT, TARDBP
6progressive supranuclear palsy30.5APP, APOE, SNCA, MAPT
7pick's disease30.5APP, APOE, SNCA, MAPT, TARDBP
8frontotemporal dementia30.5TARDBP, APP, APOE, STH, SNCA, MAPT
9parkinson's disease30.3APP, APOE, STH, SNCA, MAPT
10hemoglobin d disease10.3
11lip disease10.3
12semantic dementia10.0MAPT
13scrapie10.0MAPT
14hydrocephalus10.0MAPT
15myopathy10.0APP
16hereditary cerebral amyloid angiopathy10.0APP
17spinocerebellar ataxia type 310.0SNCA
18essential tremor10.0SNCA
19malaria10.0MAPT
20vascular dementia10.0APOE
21aphasia10.0TARDBP, MAPT
22multiple sclerosis10.0APOE
23encephalitis10.0APP
24inclusion body myositis10.0MAPT, APP
25age related macular degeneration10.0APOE
26prion disease10.0MAPT, APP
27parkinson disease type 310.0MAPT, SNCA
28multiple system atrophy10.0SNCA, MAPT
29mental retardation10.0APP, MAPT
30spinocerebellar ataxia10.0SNCA, MAPT
31movement disease10.0MAPT, SNCA
32astrocytoma10.0SNCA, APP
33central nervous system disease10.0MAPT, APP
34ischemia10.0MAPT, SNCA
35binswanger's disease10.0APP, APOE
36stroke, hemorrhagic10.0APP, APOE
37cerebrovascular disease10.0APOE, APP
38hemorrhage, intracerebral10.0APOE, APP
39myositis10.0MAPT, SNCA, APP
40diabetes mellitus10.0APOE
41niemann-pick disease10.0MAPT, SNCA, APP
42motor neuron disease10.0SNCA, MAPT, TARDBP
43huntington's disease10.0APP, SNCA, MAPT
44teratocarcinoma10.0MAPT, SNCA, APP
45cerebral amyloid angiopathy10.0MAPT, APOE, APP
46alzheimer disease type 210.0APP, APOE, MAPT
47amyloid tumor10.0MAPT, APOE, APP
48lewy body dementia10.0APOE, SNCA, MAPT
49creutzfeldt-jakob syndrome10.0APP, APOE, SNCA, MAPT
50memory impairment10.0MAPT, SNCA, APOE, APP

Graphical network of the top 20 diseases related to Argyrophilic Grain Disease:



Diseases related to argyrophilic grain disease

Clinical Features for Argyrophilic Grain Disease

Drugs & Therapeutics for Argyrophilic Grain Disease

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Argyrophilic Grain Disease

Drug clinical trials:

Search ClinicalTrials for Argyrophilic Grain Disease

Search NIH Clinical Center for Argyrophilic Grain Disease

Search CenterWatch for Argyrophilic Grain Disease

Genetic Tests for Argyrophilic Grain Disease

Anatomical Context for Argyrophilic Grain Disease

Sources:
33MalaCards
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MalaCards organs/tissues related to Argyrophilic Grain Disease:

33
Brain, Cortex, Hypothalamus, Subthalamic nucleus, Amygdala

Animal Models for Argyrophilic Grain Disease or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Argyrophilic Grain Disease:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.5SNCA, MAPT, APOE
2MP:00053958.4MAPT, APOE, APP
3MP:00030127.6APOE, APP, TARDBP, MAPT, SNCA
4MP:00053867.6APP, APOE, SNCA, MAPT, TARDBP

Publications for Argyrophilic Grain Disease

Sources:
51PubMed
See all sources

Articles related to Argyrophilic Grain Disease:

(show top 50)    (show all 54)
idTitleAuthorsYear
1
Argyrophilic grains are reliable disease-specific features of corticobasal degeneration. (24335531)
2014
2
Neuropathological characterization of two siblings carrying the MAPT S305S mutation demonstrates features resembling argyrophilic grain disease. (24337498)
2014
3
Argyrophilic grain disease as a neurodegenerative substrate in late-onset schizophrenia and delusional disorders. (24272318)
2013
4
Argyrophilic grain disease differs from other tauopathies by lacking tau acetylation. (23371364)
2013
5
Germline DNA copy number variation in individuals with Argyrophilic grain disease reveals CTNS as a plausible candidate gene. (24385851)
2013
6
Prominent psychiatric symptoms in patients with Parkinson's disease and concomitant argyrophilic grain disease. (24046066)
2013
7
Co-occurrence of argyrophilic grain disease in sporadic amyotrophic lateral sclerosis. (21702760)
2012
8
Neuronal hemoglobin is reduced in Alzheimer's disease, argyrophilic grain disease, Parkinson's disease, and dementia with Lewy bodies. (21157025)
2011
9
Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease. (21412174)
2011
10
Argyrophilic grain disease with delusions and hallucinations: a pathological study. (20738810)
2010
11
Neuropathological asymmetry in argyrophilic grain disease. (20535032)
2010
12
Accumulation of phosphorylated TDP-43 in brains of patients with argyrophilic grain disease. (19039597)
2009
13
Tracing of temporo-entorhinal connections in the human brain: cognitively impaired argyrophilic grain disease cases show dendritic alterations but no axonal disconnection of temporo-entorhinal association neurons. (18075746)
2008
14
Argyrophilic grain disease. (18234698)
2008
15
MAPT S305I mutation: implications for argyrophilic grain disease. (18066559)
2008
16
Expression levels of adenosine receptors in hippocampus and frontal cortex in argyrophilic grain disease. (17707587)
2007
17
Clinical characteristics of dementia associated with argyrophilic grain disease. (17693705)
2007
18
Coexistence of amyotrophic lateral sclerosis and argyrophilic grain disease: a non-demented autopsy case showing circumscribed temporal atrophy and involvement of the amygdala. (18021374)
2007
19
Argyrophilic grain disease in demented subjects presenting initially with amnestic mild cognitive impairment. (16783170)
2006
20
Argyrophilic grain disease: case report of the first two cases in the Czech Republic and review of the literature. (16715630)
2006
21
Argyrophilic grain disease: frequency and neuropathology in centenarians. (16525805)
2006
22
Late-onset frontotemporal dementia associated with progressive supranuclear palsy/argyrophilic grain disease/Alzheimer's disease pathology. (16006341)
2005
23
The impact of argyrophilic grain disease on the development of dementia and its relationship to concurrent Alzheimer's disease-related pathology. (15885064)
2005
24
Clinical features of argyrophilic grain disease: a retrospective survey of cases with neuropsychiatric symptoms. (16319301)
2005
25
Argyrophilic grain disease presenting with frontotemporal dementia: a neuropsychological and pathological study of an autopsied case with presenile onset. (15875911)
2005
26
Increased frequency of argyrophilic grain disease in Alzheimer disease with 4R tau-specific immunohistochemistry. (15804052)
2005
27
Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies. (15641585)
2004
28
Diffuse form of argyrophilic grain disease: a new variant of four-repeat tauopathy different from limbic argyrophilic grain disease. (14517683)
2003
29
Phosphorylated protein kinases associated with neuronal and glial tau deposits in argyrophilic grain disease. (12580546)
2003
30
Argyrophilic grain disease: molecular genetic difference to other four-repeat tauopathies. (14513264)
2003
31
Genetic association of argyrophilic grain disease with polymorphisms in alpha-2 macroglobulin and low-density lipoprotein receptor-related protein genes. (12175343)
2002
32
Pathological tau proteins in argyrophilic grain disease. (12849422)
2002
33
The subthalamic nucleus has neurofibrillary tangles in argyrophilic grain disease and advanced Alzheimer's disease. (11849769)
2002
34
Argyrophilic grain disease is a sporadic 4-repeat tauopathy. (12071638)
2002
35
Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. (12368187)
2002
36
Argyrophilic grain disease: neuropathology, frequency in a dementia brain bank and lack of relationship with apolipoprotein E. (11770901)
2002
37
Argyrophilic grain disease and Alzheimer's disease are distinguished by their different distribution of tau protein isoforms. (12200631)
2002
38
Ballooned neurons in progressive supranuclear palsy are usually due to concurrent argyrophilic grain disease. (12070664)
2002
39
Severe involvement of the ambient gyrus in a case of dementia with argyrophilic grain disease. (11959159)
2002
40
Argyrophilic grain disease mimicking temporal Pick's disease: a clinical, radiological, and pathological study of an autopsy case with a clinical course of 15 years. (11563637)
2001
41
Argyrophilic grain disease. A frequent dementing disorder in aged patients. (11403164)
2001
42
Astrocytes expressing hyperphosphorylated tau protein without glial fibrillary tangles in argyrophilic grain disease. (10483782)
1999
43
Low amyloid (Abeta) plaque load and relative predominance of diffuse plaques distinguish argyrophilic grain disease from Alzheimer's disease. (10476046)
1999
44
Dementia with grains (argyrophilic grain disease). (9546294)
1998
45
Ballooned neurons expressing alphaB-crystallin as a constant feature of the amygdala in argyrophilic grain disease. (9792618)
1998
46
Cytoskeletal alterations in the human tuberal hypothalamus related to argyrophilic grain disease. (9845289)
1998
47
Argyrophilic grain disease is associated with apolipoprotein E epsilon 2 allele. (9754952)
1998
48
Apolipoprotein E allele frequencies in argyrophilic grain disease. (9754953)
1998
49
Argyrophilic grain disease: widespread hyperphosphorylation of tau protein in limbic neurons. (9144586)
1997
50
Argyrophilic grain disease: distribution of grains in patients with and without dementia. (9341936)
1997

Genetic Variations for Argyrophilic Grain Disease

Expression for genes affiliated with Argyrophilic Grain Disease

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Argyrophilic Grain Disease

Search GEO for disease gene expression data for Argyrophilic Grain Disease.

Pathways for genes affiliated with Argyrophilic Grain Disease

Sources:
52QIAGEN, 53R&D Systems, 54Reactome, 30KEGG, 38NCBI BioSystems Database, 4Cell Signaling Technology
See all sources

Compounds for genes affiliated with Argyrophilic Grain Disease

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1cyclosporin a45 29 6012.1APP
2memantine45 29 1111.9APP, MAPT
3tmao459.9SNCA, MAPT
4valproate459.7MAPT, APP
5methionine sulfoxide45 11 2411.7APP, SNCA
6metrifonate459.5APP, APOE
724s-hydroxy-cholesterol459.5APP, APOE
8guanidine45 11 2411.5APOE, MAPT
9spec-t459.5APOE, MAPT
106-hydroxydopamine459.5SNCA, APP
11atropine45 29 1111.4APP, SNCA
12thioflavin459.4MAPT, SNCA, APP
13carbachol45 29 1111.3APP, SNCA, MAPT
14choline45 11 2411.3MAPT, SNCA, APP
15vitamin b12459.2MAPT, APOE
16c2ceramide459.2MAPT, APP
17tacrine45 1110.2APP, APOE, MAPT
18donepezil45 11 2411.2MAPT, APOE, APP
19galantamine45 50 1111.1MAPT, APOE, APP
20chloroquine45 2 50 29 1113.1MAPT, APOE, APP
21folate459.1MAPT, APOE, APP
22nicotine45 50 29 1112.1APP, APOE, MAPT
23ibuprofen45 29 50 11 2413.0APOE, APP
24guanidine hydrochloride459.0SNCA, APOE
25nmda45 2910.0APP, APOE, MAPT
26thioflavin t458.9SNCA, APOE, APP
27actinomycin d458.9APP, APOE, MAPT
28n acetylcysteine458.9MAPT, SNCA, APOE
29paraffin458.8APOE, SNCA, MAPT
30thioflavine s458.5MAPT, SNCA, APOE, APP
31formate458.5APP, APOE, SNCA, MAPT
324-hydroxynonenal45 249.5APP, APOE, SNCA, MAPT
33lactacystin458.5APP, APOE, SNCA, MAPT
34sodium dodecylsulfate458.5APP, APOE, SNCA, MAPT
35valine458.5MAPT, SNCA, APOE, APP
36acetylcholine45 50 29 11 2412.5APP, APOE, SNCA, MAPT
37glutamine458.5APP, APOE, SNCA, MAPT
38dopamine45 29 11 2411.5MAPT, SNCA, APOE, APP
39h2o2458.5MAPT, SNCA, APOE, APP
40testosterone45 60 11 2411.5APP, APOE, SNCA, MAPT
41arginine458.4APP, APOE, SNCA, MAPT
42glutamate458.4MAPT, SNCA, APOE, APP
43alanine458.4APP, APOE, SNCA, MAPT
44cholesterol45 29 11 2411.4SNCA, A2M, APOE, APP
45cysteine458.3MAPT, SNCA, APOE, APP
46heparin45 29 11 2411.1APP, APOE, A2M, SNCA, MAPT
47serine458.0MAPT, SNCA, A2M, APOE, APP

GO Terms for genes affiliated with Argyrophilic Grain Disease

Sources:
16Gene Ontology
See all sources

Cellular components related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5A2M, APP
2axonGO:0304248.6MAPT, SNCA, APP

Biological processes related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:0080889.5MAPT, APP
2positive regulation of axon extensionGO:0457739.1MAPT, APOE
3cholesterol metabolic processGO:0082039.1APOE, APP
4adult locomotory behaviorGO:0083449.0SNCA, APP

Molecular functions related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.1MAPT, APOE
2tau protein bindingGO:0481568.7SNCA, APOE
3identical protein bindingGO:0428028.0TARDBP, SNCA, APOE, APP

Products for genes affiliated with Argyrophilic Grain Disease

  • Antibodies
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Sources for Argyrophilic Grain Disease

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet