MCID: ARG005
MIFTS: 31

Argyrophilic Grain Disease malady

Neuronal diseases category

Summaries for Argyrophilic Grain Disease

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63Wikipedia, 32MalaCards
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Wikipedia:63 Tauopathies are a class of neurodegenerative diseases associated with the pathological aggregation of... more...

MalaCards: Argyrophilic Grain Disease, also known as braak disease, is related to dementia and alzheimer's disease. An important gene associated with Argyrophilic Grain Disease is STH (saitohin), and among its related pathways are Reelin Pathway (Cajal-Retzius cells) and A-beta Uptake & Degradation. The compounds cyclosporin a and memantine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are taste/olfaction and other.

Aliases & Classifications for Argyrophilic Grain Disease

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48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
argyrophilic grain disease:
Age of onset: Adulthood


Aliases & Descriptions:

argyrophilic grain disease 48
braak disease 48


External Ids:

ICD10 via Orphanet26 G31.8

Related Diseases for Argyrophilic Grain Disease

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Argyrophilic Grain Disease via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1dementia31.0APP, APOE, STH, SNCA, MAPT, TARDBP
2alzheimer's disease30.9APP, APOE, A2M, STH, SNCA, MAPT
3tauopathy30.9APP, STH, SNCA, MAPT
4brain disease30.6APP, SNCA, MAPT
5lateral sclerosis30.5SNCA, MAPT
6amyotrophic lateral sclerosis30.5APP, SNCA, MAPT, TARDBP
7progressive supranuclear palsy30.5APP, APOE, SNCA, MAPT
8parkinson's disease30.5APP, APOE, STH, SNCA, MAPT
9pick's disease30.5APP, APOE, SNCA, MAPT, TARDBP
10frontotemporal dementia30.5TARDBP, APP, APOE, STH, SNCA, MAPT
11lewy body dementia30.3APOE, SNCA, MAPT
12neuronitis10.6
13delusional disorder10.2
14schizophrenia10.2
15semantic dementia10.0MAPT
16scrapie10.0MAPT
17hydrocephalus10.0MAPT
18myopathy10.0APP
19hereditary cerebral amyloid angiopathy10.0APP
20spinocerebellar ataxia type 310.0SNCA
21essential tremor10.0SNCA
22malaria10.0MAPT
23vascular dementia10.0APOE
24aphasia10.0TARDBP, MAPT
25multiple sclerosis10.0APOE
26encephalitis10.0APP
27inclusion body myositis10.0MAPT, APP
28age related macular degeneration10.0APOE
29prion disease10.0MAPT, APP
30parkinson disease type 310.0MAPT, SNCA
31multiple system atrophy10.0SNCA, MAPT
32mental retardation10.0APP, MAPT
33spinocerebellar ataxia10.0SNCA, MAPT
34movement disease10.0MAPT, SNCA
35astrocytoma10.0SNCA, APP
36central nervous system disease10.0MAPT, APP
37ischemia10.0MAPT, SNCA
38binswanger's disease10.0APP, APOE
39stroke, hemorrhagic10.0APP, APOE
40cerebrovascular disease10.0APOE, APP
41hemorrhage, intracerebral10.0APOE, APP
42myositis10.0MAPT, SNCA, APP
43diabetes mellitus10.0APOE
44niemann-pick disease10.0MAPT, SNCA, APP
45motor neuron disease10.0SNCA, MAPT, TARDBP
46huntington's disease10.0APP, SNCA, MAPT
47teratocarcinoma10.0MAPT, SNCA, APP
48cerebral amyloid angiopathy10.0MAPT, APOE, APP
49alzheimer disease type 210.0APP, APOE, MAPT
50amyloid tumor10.0MAPT, APOE, APP

Graphical network of the top 20 diseases related to Argyrophilic Grain Disease:



Diseases related to argyrophilic grain disease

Clinical Features for Argyrophilic Grain Disease

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Drugs & Therapeutics for Argyrophilic Grain Disease

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Argyrophilic Grain Disease

Drug clinical trials:

Search ClinicalTrials for Argyrophilic Grain Disease

Search NIH Clinical Center for Argyrophilic Grain Disease

Search CenterWatch for Argyrophilic Grain Disease

Genetic Tests for Argyrophilic Grain Disease

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Anatomical Context for Argyrophilic Grain Disease

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32MalaCards
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MalaCards organs/tissues related to Argyrophilic Grain Disease:

32
Brain

Animal Models for Argyrophilic Grain Disease or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Argyrophilic Grain Disease:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053948.5MAPT, SNCA, APOE
2MP:00053958.4APP, APOE, MAPT
3MP:00030127.6TARDBP, MAPT, SNCA, APOE, APP
4MP:00053867.6TARDBP, MAPT, SNCA, APOE, APP

Publications for Argyrophilic Grain Disease

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Genetic Variations for Argyrophilic Grain Disease

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Expression for genes affiliated with Argyrophilic Grain Disease

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Argyrophilic Grain Disease

Search GEO for disease gene expression data for Argyrophilic Grain Disease.

Pathways for genes affiliated with Argyrophilic Grain Disease

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Sources:
51QIAGEN, 52R&D Systems, 53Reactome, 29KEGG, 37NCBI BioSystems Database, 4Cell Signaling Technology
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Compounds for genes affiliated with Argyrophilic Grain Disease

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

(show all 47)
idCompoundScoreTop Affiliating Genes
1cyclosporin a44 28 5912.1APP
2memantine44 28 1111.9APP, MAPT
3tmao449.9SNCA, MAPT
4valproate449.7MAPT, APP
5methionine sulfoxide44 11 2411.7APP, SNCA
6metrifonate449.5APP, APOE
724s-hydroxy-cholesterol449.5APP, APOE
8guanidine44 11 2411.5APOE, MAPT
9spec-t449.5APOE, MAPT
106-hydroxydopamine449.5SNCA, APP
11atropine44 28 1111.4APP, SNCA
12thioflavin449.4MAPT, SNCA, APP
13carbachol44 28 1111.3APP, SNCA, MAPT
14choline44 11 2411.3MAPT, SNCA, APP
15vitamin b12449.2MAPT, APOE
16c2ceramide449.2MAPT, APP
17tacrine44 1110.2APP, APOE, MAPT
18donepezil44 11 2411.2MAPT, APOE, APP
19galantamine44 49 1111.1MAPT, APOE, APP
20chloroquine44 2 49 28 1113.1MAPT, APOE, APP
21folate449.1MAPT, APOE, APP
22nicotine44 49 28 1112.1APP, APOE, MAPT
23ibuprofen44 28 49 11 2413.0APOE, APP
24guanidine hydrochloride449.0SNCA, APOE
25nmda44 2810.0APP, APOE, MAPT
26thioflavin t448.9SNCA, APOE, APP
27actinomycin d448.9APP, APOE, MAPT
28n acetylcysteine448.9MAPT, SNCA, APOE
29paraffin448.8APOE, SNCA, MAPT
30thioflavine s448.5MAPT, SNCA, APOE, APP
31formate448.5APP, APOE, SNCA, MAPT
324-hydroxynonenal44 249.5APP, APOE, SNCA, MAPT
33lactacystin448.5APP, APOE, SNCA, MAPT
34sodium dodecylsulfate448.5APP, APOE, SNCA, MAPT
35valine448.5MAPT, SNCA, APOE, APP
36acetylcholine44 49 28 11 2412.5APP, APOE, SNCA, MAPT
37glutamine448.5APP, APOE, SNCA, MAPT
38dopamine44 28 11 2411.5MAPT, SNCA, APOE, APP
39h2o2448.5MAPT, SNCA, APOE, APP
40testosterone44 59 11 2411.5APP, APOE, SNCA, MAPT
41arginine448.4APP, APOE, SNCA, MAPT
42glutamate448.4MAPT, SNCA, APOE, APP
43alanine448.4APP, APOE, SNCA, MAPT
44cholesterol44 28 11 2411.4SNCA, A2M, APOE, APP
45cysteine448.3MAPT, SNCA, APOE, APP
46heparin44 28 11 2411.1APP, APOE, A2M, SNCA, MAPT
47serine448.0MAPT, SNCA, A2M, APOE, APP

GO Terms for genes affiliated with Argyrophilic Grain Disease

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Sources:
16Gene Ontology
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Cellular components related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet alpha granule lumenGO:0310939.5A2M, APP
2axonGO:0304248.6MAPT, SNCA, APP

Biological processes related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1axon cargo transportGO:0080889.5MAPT, APP
2positive regulation of axon extensionGO:0457739.1MAPT, APOE
3cholesterol metabolic processGO:0082039.1APOE, APP
4adult locomotory behaviorGO:0083449.0SNCA, APP

Molecular functions related to Argyrophilic Grain Disease according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipoprotein particle bindingGO:0718139.1MAPT, APOE
2tau protein bindingGO:0481568.7SNCA, APOE
3identical protein bindingGO:0428028.0TARDBP, SNCA, APOE, APP

Products for genes affiliated with Argyrophilic Grain Disease

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Argyrophilic Grain Disease

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet