Arterial Occlusive Disease malady

Wikipedia: Peripheral vascular disease (PVD), commonly referred to as peripheral arterial disease (PAD) or...⁴⁴ more...

MalaCards: Arterial Occlusive Disease, also known as arterial occlusive diseases, is related to peripheral arterial occlusive disease and thrombosis. An important gene associated with Arterial Occlusive Disease is PAOD1 (Peripheral arterial occlusive disease 1), and among its related pathways are Cell adhesion molecules (CAMs) and RAR-Gamma-RXR-Alpha Degradation. The drugs alteplase,recombinant and papaverine and the compounds nicotine and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and skeletal muscle, and related mouse phenotypes are skeleton and endocrine/exocrine gland.

Aliases & Descriptions:

arterial occlusive disease 6 8 arterial occlusive diseases 32 43

Diseases related to arterial occlusive disease by text searches and GeneDecks gene sharing:

(show top 50)    (show all 760)

id	Related Disease	Score	Top Affiliating Genes
1	peripheral arterial occlusive disease	31.3	VWF, SELE, SELP, SERPINE1, VCAM1, PAFAH2
2	thrombosis	30.1	MTHFR, F5, F2
3	peripheral vascular disease	29.9	VWF, SELE, SELP, SERPINE1, VCAM1, ACE
4	carotid artery occlusion	29.8	APOH, THBD, CX3CR1
5	vascular disease	29.6	KL, NOTCH3, NOTCH4
6	protein c deficiency	27.7	SERPINC1, SERPINE1, MTHFR, FGA, APOH, F5
7	cerebral artery occlusion	27.7	SELP, SERPINE1, APOH, ICAM1, CRP, PLAT
8	protein s deficiency	27.2	SERPINC1, SERPINE1, MTHFR, FGA, APOH, F5
9	thrombophilia	26.1	VWF, SELE, SELP, SERPINC1, SERPINE1, MTHFR
10	type 2 diabetes mellitus	25.9	VWF, SELE, SELP, SERPINE1, VCAM1, MTHFR
11	hyperhomocysteinemia	25.6	VWF, SELE, SELP, SERPINC1, SERPINE1, VCAM1
12	homocysteine	23.1	VWF, PCNA, SELE, SELP, SERPINC1, SERPINE1
13	abdominal aortic aneurysm	22.3	VWF, SELE, SERPINC1, SERPINE1, MTHFR, CD40LG
14	aortic aneurysm	21.8	VWF, SELE, SERPINC1, SERPINE1, MTHFR, CD40LG
15	diabetes mellitus	19.7	VWF, SELE, SELP, SERPINC1, SERPINE1, VCAM1
16	atherosclerosis	19.2	KL, VWF, PCNA, SELE, SELP, SERPINC1
17	cerebritis	16.8	VWF, PCNA, SELE, SELP, SERPINC1, SERPINE1
18	genee-wiedemann syndrome	13.8	PLAT, THBD
19	coronary artery disease, modifier of	13.7	CCL2, ACE
20	malignant spiradenoma	13.7	CD40LG, CD40
21	chronic pulmonary heart disease	13.7	EDN1, ADIPOQ
22	hemarthrosis	13.6	VWF, F3, F2
23	achenbach syndrome	13.6	F3, F2, PLAT
24	lymphocytic vasculitis	13.6	SELE, VCAM1, ICAM1
25	diabetic angiopathy	13.6	SELE, EDN1, THBD, ADM
26	rheumatoid vasculitis	13.6	SELE, VCAM1, ICAM1
27	leukostasis	13.6	SELE, VCAM1, ICAM1
28	central serous chorioretinopathy	13.6	SERPINE1, PLAT
29	acute poststreptococcal glomerulonephritis	13.6	CCL2, HP, EDN1
30	factor xii deficiency	13.6	F5, F3, F2
31	mthfr deficiency	13.6	MTHFR, CBS
32	lymphoplasmacytic lymphoma	13.6	CD40LG, F3, F2
33	factor x deficiency	13.6	F5, F3, F2
34	type 3 von willebrand disease	13.6	VWF, PLAT
35	essential thrombocythemia	13.6	VWF, SELP, THBD
36	factor v deficiency	13.6	F5, F3, F2
37	stroke, ischemic	13.6	F5, F2
38	angiodysplasia	13.6	VWF, SERPINE1, F3
39	rheumatoid nodulosis	13.6	SELE, VCAM1
40	african tick-bite fever	13.6	VWF, SELE, CD40LG, GPT
41	renal hypertension	13.6	EDN1, ACE, ADM
42	dengue disease	13.6	VCAM1, ICAM1, F3
43	afibrinogenemia	13.6	VWF, FGA, F3, F2
44	vascular malformations	13.6	VWF, CCL2, F3, F2
45	autoimmune thrombocytopenic purpura	13.6	SELP, CD40LG, CD40
46	acquired von willebrand syndrome	13.6	VWF, CD40LG, F3, F2
47	bernard-soulier syndrome	13.6	VWF, FGA, F2
48	hemophilia b	13.6	VWF, F3, F2
49	ariboflavinosis	13.5	MTHFR, GSR
50	eisenmenger syndrome	13.5	VWF, EDN1, ACE, THBD

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alteplase,recombinant, papaverine, papaverine hydrochloride, streptokinase

Cell-based therapeutics:

MalaCards organs/tissues related to arterial occlusive disease:

²²

MGI Mouse Phenotypes related to arterial occlusive disease:

²⁵ (show all 21)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	skeleton phenotype	MP:0005390	9.7	PLAT, IL6, FGA, MTHFR
2	endocrine/exocrine gland phenotype	MP:0005379	9.6	KL, CD40LG
3	renal/urinary system phenotype	MP:0005367	9.6	ADM, NOTCH3, CBS, SELP, KL
4	respiratory system phenotype	MP:0005388	9.5	NOTCH3, CYBA, CBS, SELP, KL
5	embryogenesis phenotype	MP:0005380	9.3	SERPINC1, F2, CBS, NOTCH4
6	hematopoietic system phenotype	MP:0005397	9.3	PCNA, NOTCH3, CX3CR1
7	reproductive system phenotype	MP:0005389	9.0	ADIPOQ, NOTCH3, CBS, CCR5, CCL2, IL6
8	integument phenotype	MP:0010771	8.9	CX3CR1, PROS1, OSM, CBS, F2, F3
9	immune system phenotype	MP:0005387	8.8	CBS, CYBA, PLAT, NOTCH3, ADM, ADIPOQ
10	liver/biliary system phenotype	MP:0005370	8.6	ADM, PROS1, CBS, CCR5, IL6, FGA
11	digestive/alimentary phenotype	MP:0005381	8.3	CX3CR1, EDN1, PLAT, F2, CCR5, CCL2
12	tumorigenesis	MP:0002006	7.8	HP, NOTCH3, ACE, ADIPOQ, F3, ICAM1
13	vision/eye phenotype	MP:0005391	7.5	CCR5, ICAM1, F3, CBS, PLAT, CX3CR1
14	muscle phenotype	MP:0005369	7.5	PLAT, NOTCH3, EDN1, CX3CR1, ADM, ADIPOQ
15	growth/size phenotype	MP:0005378	7.4	PLAT, NOTCH3, NOTCH4, ACE, THBD, CX3CR1
16	behavior/neurological phenotype	MP:0005386	7.3	HSPA4, CYBA, PLAT, ACE, OSM, CX3CR1
17	nervous system phenotype	MP:0003631	7.3	HSPA4, NOTCH4, EDN1, THBD, OSM, PROS1
18	cellular phenotype	MP:0005384	5.2	PLAT, HP, HSPA4, CBS, F2, NOTCH3
19	cardiovascular system phenotype	MP:0005385	3.9	SERPINE1, F3, F2, CBS, HP, CRP
20	mortality/aging	MP:0010768	3.3	HP, HSPA4, CBS, F2, F3, ICAM1
21	homeostasis/metabolism phenotype	MP:0005376	2.9	KL, FGA, IL18, IL1B, IL6, APOH

Articles related to arterial occlusive disease:

(show top 50)    (show all 51)

id	Title	Authors	Year	Affiliating Genes
1	The role of oxidative stress and antioxidant defenses in Buerger disease and atherosclerotic peripheral arterial occlusive disease. (19128930)	Arslan C.... Denli S.	2010	GSR, PON1
2	Effect of cilostazol treatment on adiponectin and sol uble CD40 ligand levels in diabetic patients with peripheral arterial occlusion disease. (19282610)	Hsieh C.J.... Wang P.W.	2009	CD40LG, ADIPOQ
3	Thrombophilias and peripheral arterial occlusive disease (18554834)	le Hello C.... Constans J.	2008	F5
4	No effect of homocysteine-lowering therapy on vascular inflammation and haemostasis in peripheral arterial occlusive disease. (16634837)	Schernthaner G.H.... Schernthaner G.	2006	CCL2, IL18, F3
5	Markers of vascular inflammation are associated with the extent of atherosclerosis assessed as angiographic score and treadmill walking distances in patients with peripheral arterial occlusive disease. (16669409)	Nylaende M.... Seljeflot I.	2006	IL6, CCL2
6	A single nucleotide polymorphism in the plasma PAF acetylhydrolase gene and risk of atherosclerosis in Japanese patients with peripheral artery occlusive disease. (16650870)	Unno N.... Konno H.	2006	PLA2G7, PAFAH2
7	Adiponectin and inflammatory markers in peripheral arterial occlusive disease. (16321391)	Iwashima Y.... Kawano Y.	2006	ADIPOQ
8	Double jeopardy: how soluble P-selectin activates leukocytes in peripheral arterial occlusive disease. (16397153)	Galkina E.... Ley K.	2006	SELP
9	Mutation in factor II and factor V gene in patients with peripheral arterial occlusive disease (16906235)	Abukishe A.... Bruhn H.D.	2006	F2, F5
10	Raised plasma soluble P-selectin in peripheral arterial occlusive disease enhances leukocyte adhesion. (16339486)	Woollard K.J.... Chin-Dusting J.	2006	SELP
11	Interleukin-1beta C+3953T gene polymorphism and peripheral arterial occlusive disease in Polish population (16541711)	Potaczek D.P.... Sanak M.	2005	IL1B
12	LDL-apheresis improves peripheral arterial occlusive disease with an implication for anti-inflammatory effects. (15880405)	Kobayashi S.... Ohtake T.	2005	CCL2
13	Lack of an association between angiotensin converting enzyme gene polymorphism and peripheral arterial occlusive disease. (15675183)	Karagiannis A.... Zamboulis C.	2004	ACE
14	Plasma adrenomedullin concentration is increased in patients with peripheral arterial occlusive disease associated with vascular inflammation. (14759562)	Suzuki Y.... Kawano Y.	2004	ADM
15	Reteplase monotherapy and reteplase/abciximab combination therapy in peripheral arterial occlusive disease: results from the RELAX trial. (15028807)	Ouriel K.... Duda S.	2004	PLAT
16	Clot lysis in a primate model of peripheral arterial occlusive disease with use of systemic or intraarterial reteplase: addition of abciximab results in improved vessel reperfusion. (14963184)	Nakada M.T.... Jordan R.E.	2004	PLAT
17	Genetic risk factor characterizes abdominal aortic aneurysm from arterial occlusive disease in human beings: CCR5 Delta 32 deletion. (15557916)	Ghilardi G.... Scorza R.	2004	CCR5
18	Internal carotid artery occlusive disease and polymorphisms of fractalkine receptor CX3CR1: a genetic risk factor. (15118174)	Ghilardi G.... Scorza R.	2004	CX3CR1
19	Use of abciximab and tirofiban in patients with perip heral arterial occlusive disease and arterial thrombosis. (12678189)	Schweizer J.... Forkmann L.	2003	F3
20	C-reactive protein predicts further ischemic events in first-ever transient ischemic attack or stroke patients with intracranial large-artery occlusive disease. (14500938)	Arenillas J.F.... Quintana M.	2003	CRP
21	The K469E polymorphism of the ICAM-1 gene is a risk factor for peripheral arterial occlusive disease. (12192299)	Gaetani E.... Pola P.	2002	ICAM1
22	Localization of a gene for peripheral arterial occlusive disease to chromosome 1p31. (11833003)	Gudmundsson G.... Stefansson K.	2002	PAOD1
23	HSP70 expression in skeletal muscle of patients with peripheral arterial occlusive disease. (12217291)	Liu Y.... Steinacker J.M.	2002	HSPA4
24	Initial experience with the combination of reteplase and abciximab for thrombolytic therapy in peripheral arterial occlusive disease: a pilot study. (11788692)	Drescher P.... Rilling W.S.	2002	PLAT
25	The -174 G/C polymorphism of the interleukin-6 gene promoter is associated with peripheral artery occlusive disease. (12217290)	Flex A.... Pola P.	2002	IL6
26	Relationship between antiphospholipid antibodies and progression of lower extremity arterial occlusive disease after lower extremity bypass operations. (11331837)	Lam E.Y.... Moneta G.L.	2001	APOH
27	Factor II G20210A and factor V G1691A gene mutations and peripheral arterial occlusive disease. (10669148)	Renner W.... Pilger E.	2000	F2, F5
28	Platelets and cytokines in concert with endothelial activation in patients with peripheral arterial occlusive disease. (10759010)	Tsakiris D.A.... Marbet G.A.	2000	CD40LG, VCAM1, CD40
29	C242T polymorphism of the p22 phox gene is not associated with peripheral arterial occlusive disease. (10996353)	Renner W.... Pilger E.	2000	CYBA
30	Atrophy of the corpus callosum associated with a decrease in cortical benzodiazepine receptor in large cerebral arterial occlusive diseases. (10675213)	Yamauchi H.... Shio H.	2000	TSPO
31	Contribution of the cystathionine beta-synthase gene (844ins68) polymorphism to the risk of early-onset venous and arterial occlusive disease and of fasting hyperhomocysteinemia. (11057853)	de Franchis R.... D'Angelo A.	2000	CBS, MTHFR
32	Chronic peripheral arterial occlusive disease, platelet glycoproteins GPIIb-IIIa and GP Ib-IX, plasma von Willebrand factor and plasma fibrinogen concentrations in patients with type 2 diabetes mellitus (11236240)	Gosk-Bierska I.... Ciosek W.	2000	VWF
33	Elevated levels of soluble E-selectin in diabetic patients with severe symptomatic peripheral arterial occlusive disease requiring angioplasty. A possible role in diabetic vascular disease? (10905802)	Elhadd T.A.... Belch J.J.	2000	SELE
34	Angiotensin-converting enzyme gene insertion/deletion polymorphism and carotid artery wall thickness in patients with peripheral arterial occlusive disease. (11305733)	Taute B.M.... Podhaisky H.	2000	ACE
35	Treadmill exercise-induced release of endothelin-1 in patients with peripheral arterial occlusive disease at Fontaine stage IIb. (10853680)	Mangiafico R.A.... Attina T.	2000	EDN1
36	Thrombolytic therapy with use of alteplase (rt-PA) in peripheral arterial occlusive disease: review of the clinical literature. The Advisory Panel. (10716384)	Semba C.P.... Matalon T.A.	2000	PLAT
37	Haptoglobin polymorphism and peripheral arterial occlusive disease. (10488955)	Delanghe J.... Clement D.	1999	HP
38	Circulating cell adhesion molecules and endothelial markers before and after transluminal angioplasty in peripheral arterial occlusive disease. (9920521)	Tsakiris D.A.... Marbet G.A.	1999	VWF, SELP, SELE
39	Alteration of the fibrinolytic system in patients with peripheral arterial occlusive disease. (10409921)	Poredos P.... Gacnik A.	1999	PLAT
40	Analysis of 45 episodes of arterial occlusive disease in Japanese patients with congenital protein C deficiency. (10230891)	Sakata T.... Miyata T.	1999	SERPINC1
41	Changes in the fibrinolytic system in patients with peripheral arterial occlusive disease undergoing percutaneous transluminal angioplasty. (10336240)	Roller R.E.... Wojta J.	1999	SERPINE1
42	Decrease in P-selectin levels in patients with hypercholesterolaemia and peripheral arterial occlusive disease after lipid-lowering treatment. (10355866)	Kirk G.... Belch J.J.	1999	SELP
43	Plasma endothelin-1 levels in patients with peripheral arterial occlusive disease at different Fontaine's stages. (10230252)	Mangiafico R.A.... Santangelo B.	1999	EDN1
44	Angiotensin-converting enzyme gene insertion/deletion polymorphism and peripheral arterial occlusive disease. (9747149)	Taute B.M.... Podhaisky H.	1998	ACE
45	Human homocysteine catabolism: three major pathways and their relevance to development of arterial occlusive disease. (8642474)	Dudman N.P.... Wilcken D.E.	1996	CBS
46	Instrumental and metabolic evaluation of patients affected by peripheral arterial occlusive disease (PAOD) following surgical revascularization surgery. (9287278)	Pastoris O.... Dossena M.	1996	CS, GPT
47	Prevalence of moderate hyperhomocysteinemia in patients with early-onset venous and arterial occlusive disease. (7574192)	Fermo I.... D'Angelo A.	1995	SERPINC1, F5
48	Human transluminally placed endovascular stented grafts: preliminary histopathologic analysis of healing grafts in aortoiliac and femoral artery occlusive disease. (7535869)	Marin M.L.... Wengerter K.R.	1995	PCNA
49	D-dimer in local thrombolytic therapy with low doses of recombinant human tissue-type plasminogen activator (rt-PA) in patients with peripheral arterial occlusive disease. (2125370)	Koppensteiner R.... Ehringer H.	1990	PLAT
50	Hereditary protein S deficiency in young adults with arterial occlusive disease. (2148653)	Allaart C.F.... Briet E.	1990	SERPINC1, PROS1

Genes related to arterial occlusive disease according to GeneCards:

(show all 46)

id	Symbol	Description	Score	GeneCards Section Context
1	PAOD1	Peripheral arterial occlusive disease 1	11.1	Publications, Aliases & Descriptions
2	PLAT	plasminogen activator, tissue	11.0	Publications
3	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
4	SELE	selectin E	11.0	Publications
5	F3	coagulation factor III (thromboplastin, tissue factor)	11.0	Publications
6	VWF	von Willebrand factor	11.0	Publications
7	THBD	thrombomodulin	11.0	Publications
8	VCAM1	vascular cell adhesion molecule 1	11.0	Publications
9	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications
10	PAFAH2	platelet-activating factor acetylhydrolase 2, 40kDa	11.0	Publications
11	CBS	cystathionine-beta-synthase	11.0	Publications
12	OSM	oncostatin M	11.0	Publications
13	FGA	fibrinogen alpha chain	11.0	Publications
14	ADM	adrenomedullin	11.0	Publications
15	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
16	CS	citrate synthase	11.0	Publications
17	CYBA	cytochrome b-245, alpha polypeptide	11.0	Publications
18	HP	haptoglobin	11.0	Publications
19	PON1	paraoxonase 1	11.0	Publications
20	IL18	interleukin 18 (interferon-gamma-inducing factor)	11.0	Publications
21	ADIPOQ	adiponectin, C1Q and collagen domain containing	11.0	Publications
22	CD40LG	CD40 ligand	11.0	Publications
23	CD40	CD40 molecule, TNF receptor superfamily member 5	11.0	Publications
24	EDN1	endothelin 1	11.0	Publications
25	F5	coagulation factor V (proaccelerin, labile factor)	11.0	Publications
26	GPT	glutamic-pyruvate transaminase (alanine aminotransferase)	11.0	Publications
27	GSR	glutathione reductase	11.0	Publications
28	HSPA4	heat shock 70kDa protein 4	11.0	Publications
29	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
30	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications
31	F2	coagulation factor II (thrombin)	11.0	Publications
32	ICAM1	intercellular adhesion molecule 1	11.0	Publications
33	IL1B	interleukin 1, beta	11.0	Publications
34	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
35	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
36	CX3CR1	chemokine (C-X3-C motif) receptor 1	11.0	Publications
37	TSPO	translocator protein (18kDa)	11.0	Publications
38	NOTCH4	notch 4	11.0
39	PROS1	protein S (alpha)	11.0	Publications
40	KL	klotho	11.0
41	NOTCH3	notch 3	11.0
42	APOH	apolipoprotein H (beta-2-glycoprotein I)	11.0	Publications
43	SERPINC1	serpin peptidase inhibitor, clade C (antithrombin), member 1	11.0	Publications
44	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
45	PCNA	proliferating cell nuclear antigen	11.0	Publications
46	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to arterial occlusive disease according to GeneDecks:

(show all 28)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion molecules (CAMs)20	10.5	SELP, CD40
2	RAR-Gamma-RXR-Alpha Degradation36	10.3	OSM
3	LDL Oxidation in Atherogenesis36	10.1	VCAM1, IL1B, CCL2, ICAM1
4	Immune System38	10.1	VCAM1, CD40, IL18, ICAM1
5	NOD-like receptor signaling pathway20	9.9	IL18, IL1B, IL6, CCL2
6	MIF Mediated Glucocorticoid Regulation36	9.9	OSM, CCL2, IL6, IL1B, IL18
7	Immune response IL-1 signaling pathway10	9.8	EDN1, F3, IL6, IL1B, SERPINE1
8	Endothelin-1 Signaling Pathway36	9.8	OSM, EDN1, IL6, IL1B, IL18
9	Immune response_IL-1 signaling pathway41	9.8	EDN1, F3, IL6, IL1B, SERPINE1
10	MIF Regulation of Innate Immune Cells36	9.8	OSM, CCL2, IL6, IL1B, IL18
11	Rheumatoid arthritis20	9.8	ICAM1, CCL2, IL6, IL1B, IL18
12	African trypanosomiasis20	9.8	ICAM1, IL6, IL1B, IL18, VCAM1, SELE
13	Chagas disease (American trypanosomiasis)20	9.7	ACE, CCL2, IL6, IL1B, SERPINE1
14	Selected targets of GCR-alpha10	9.7	THBD, NOTCH4, IL6, IL1B
15	all-trans-Retinoic Acid Signaling in Brain36	9.7	OSM, CCL2, IL6, IL1B, IL18
16	PEDF Induced Signaling36	9.6	OSM, CCL2, IL6, IL1B, IL18
17	Molecular Mechanisms of Cancer36	9.6	IL6, NOTCH4, OSM, CX3CR1
18	Influenza A20	9.5	IL18, IL1B, IL6, CCL2, ICAM1
19	Intrinsic Prothrombin Activation Pathway36	9.3	PROS1, THBD, F2, F5, FGA, SERPINC1
20	Malaria20	9.3	SELE, ICAM1, SELP, VCAM1, CD40LG, CD40
21	Extrinsic Prothrombin Activation Pathway36	9.3	PROS1, THBD, F2, F3, F5, FGA
22	Blood Coagulation Cascade36	9.3	PROS1, THBD, F2, F3, F5, FGA
23	Blood Coagulation Signaling Pathways37	9.0	SERPINC1, SERPINE1, F5, F3, F2, PLAT
24	STAT3 Pathway36	9.0	CX3CR1, OSM, CCR5, CCL2, IL6, IL1B
25	Complement and coagulation cascades20	8.9	PROS1, THBD, PLAT, F2, F3, F5
26	Antioxidant Action of Vitamin-C36	8.9	CX3CR1, OSM, PLA2G7, CCR5, CCL2, IL6
27	Cytokine-cytokine receptor interaction20	8.7	CX3CR1, OSM, CCR5, CCL2, IL6, IL1B
28	p38 Signaling36	8.4	CX3CR1, OSM, CCR5, CCL2, IL6, IL1B

Compounds related to arterial occlusive disease according to GeneDecks:

(show top 50)    (show all 377)

id	Compound	Score	Top Affiliating Genes
1	nicotine32 34 9 9	13.6	GPT
2	cyclophosphamide32 34 9 9	13.3	APOH
3	hirudin32	10.0	THBD, F5, FGA, SERPINC1
4	polyethylene glycol32	9.9	PON1, THBD, HP, SERPINC1, SELE
5	clopidogrel32 34 9 18 9	13.8	ACE, CD40, CD40LG, SERPINC1
6	pge232	9.7	ADIPOQ, ADM, OSM, EDN1, PLA2G7, HP
7	epinephrine32 9 18 9	12.7	HP, F2, F3, F5, FGA, GSR
8	abciximab32 9 9	11.6	CD40, CD40LG, VWF, CRP, F2, F3
9	ascorbic acid32 18	10.6	CD40LG, PCNA, HSPA4, CS
10	ivig32	9.6	PLA2G7, CRP, CCR5, VWF
11	aprotinin32 9 9	11.5	THBD, PLAT, F2, F5, FGA, SERPINC1
12	bivalirudin32 9 9	11.5	THBD, PLAT, F2, F3, F5, FGA
13	11-dehydrothromboxane b232	9.5	F2, APOH, FGA, SERPINE1, SELP, VWF
14	iloprost32 42 9 9	12.5	PLAT, F3, VCAM1, SERPINC1, SELP, SELE
15	desmopressin32 42 9 9	12.3	THBD, PLAT, F2, F3, F5, SERPINE1
16	sb 20358032 42	10.2	EDN1, CRP, HSPA4, IL6, VCAM1, SELE
17	heparin32 9 18 9	12.1	VWF, ADIPOQ, PROS1, HP, F2, F3
18	tirofiban32 9 9	11.1	PLAT, CRP, F2, F3, CD40LG, SERPINC1
19	fluvastatin32 34 9 9	11.9	IL6, CD40, VCAM1, SERPINE1, SELP, VWF
20	pravastatin32 34 9 18 9	12.9	ADIPOQ, THBD, CRP, CCL2, IL6, IL18
21	aspartate32	8.6	PCNA, THBD, HP, F2, F5, IL18
22	vitamin-e32	8.5	GPT, CCR5, GSR, CD40, VCAM1, F5
23	kininogen32	8.5	SERPINC1, SELP, VWF, SERPINE1, APOH, THBD
24	vitamin b1232	8.5	VWF, PCNA, MTHFR, PON1, HP, CBS
25	norepinephrine32 9 18 9	11.3	ADIPOQ, ADM, TSPO, ACE, EDN1, CRP
26	p00232	8.3	PLAT, PLA2G7, CRP, HP, CBS, F5
27	8-isoprostane32	8.2	ADIPOQ, SERPINE1, SELE, VCAM1, IL6, PON1
28	cocaine32 9 9	10.2	GPT, CCR5, APOH, GSR, CD40LG, VCAM1
29	dextran sulfate32	8.2	CCR5, APOH, IL6, CD40LG, SERPINC1, SELP
30	rantes32	8.1	ADIPOQ, CX3CR1, OSM, ICAM1, CCR5, CCL2
31	atorvastatin32 34 9 18 9	12.1	ADIPOQ, IL18, CD40, CD40LG, VCAM1, SELP
32	polysaccharide32	8.0	HP, SELE, SELP, SERPINC1, F3, ICAM1
33	losartan32 34 9 9	11.0	ADIPOQ, ADM, THBD, ACE, EDN1, PLAT
34	cycloheximide32	7.8	F3, ICAM1, CCL2, IL6, IL1B, IL18
35	folate32	7.6	HP, CBS, F5, APOH, IL18, GSR
36	simvastatin32 34 42 9 18 9	12.2	ADIPOQ, PON1, THBD, PLAT, CD40, VCAM1
37	homocysteine32 18	8.0	PLAT, VCAM1, SERPINE1, SERPINC1, SELP, SELE
38	lipid32	6.8	IL6, IL18, FGA, GSR, CD40, VCAM1
39	estrogen32	6.7	THBD, TSPO, PLA2G7, HP, F2, APOH
40	histamine32 18	7.7	CD40, CD40LG, VCAM1, SELP, SELE, PCNA
41	prostacyclin32	6.6	CRP, F3, ICAM1, F5, CCL2, APOH
42	alanine32	6.4	CCR5, IL6, IL18, CD40LG, VCAM1, SERPINC1
43	arginine32	6.2	PROS1, THBD, TSPO, EDN1, NOTCH3, CBS
44	serine32	6.0	ADIPOQ, F2, F3, F5, CCR5, CCL2
45	cyclosporin a32 42	6.9	CS, THBD, TSPO, EDN1, PLAT, HP
46	aspirin32 34 18	7.8	MTHFR, SERPINE1, SERPINC1, SELP, SELE, PCNA
47	lactate32	5.7	PCNA, VWF, ADIPOQ, APOH, IL6, IL18
48	dexamethasone32 42 34 9 9	9.4	ADIPOQ, ADM, CS, PROS1, IL1B, IL18
49	creatinine32	5.0	PROS1, APOH, IL18, FGA, CD40, CD40LG
50	vegf32	4.2	CCL2, SELE, PCNA, VWF, KL, SELP

Cellular components related to arterial occlusive disease according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	platelet alpha granule lumen	GO:031093	9.5	PROS1, F5, FGA, SERPINE1, VWF
2	extracellular matrix	GO:031012	9.3	PLAT, F3, APOH, SERPINE1, VWF
3	cell surface	GO:009986	8.8	VCAM1, APOH, CCR5, PLAT, NOTCH4, THBD
4	external side of plasma membrane	GO:009897	8.8	ACE, ICAM1, CCR5, FGA, CD40, CD40LG
5	plasma membrane	GO:005886	5.9	ICAM1, F3, F2, NOTCH3, NOTCH4, ACE
6	extracellular region	GO:005576	5.5	CRP, PLA2G7, PLAT, NOTCH3, NOTCH4, EDN1
7	extracellular space	GO:005615	5.3	KL, F3, F2, HP, CRP, PLAT

Biological processes related to arterial occlusive disease according to GeneDecks:

(show all 33)

id	Name	GO ID	Score	Top Affiliating Genes
1	leukocyte tethering or rolling	GO:050901	10.5	SELE, SELP, VCAM1
2	negative regulation of hormone secretion	GO:046888	10.3	EDN1, OSM, ADIPOQ
3	heterophilic cell-cell adhesion	GO:007157	10.3	SELE, SELP, VCAM1, ICAM1
4	leukocyte cell-cell adhesion	GO:007159	10.2	ICAM1, CD40LG, VCAM1, SELP, SELE
5	response to lipopolysaccharide	GO:032496	10.2	ADM, THBD, EDN1, F3, SELP, SELE
6	defense response to Gram-negative bacterium	GO:050829	10.2	SELP, SERPINE1, IL6
7	cellular response to tumor necrosis factor	GO:071356	10.1	EDN1, ICAM1, CCL2, IL18
8	response to amino acid stimulus	GO:043200	10.1	EDN1, ICAM1, CCL2
9	positive regulation of monocyte chemotactic protein-1 production	GO:071639	10.1	IL1B, ADIPOQ
10	response to heat	GO:009408	10.1	OSM, HSPA4, CCL2, IL1B
11	positive regulation of interleukin-8 production	GO:032757	10.1	SERPINE1, IL18, IL1B, ADIPOQ
12	response to wounding	GO:009611	10.0	ADM, CX3CR1, F2, VWF
13	cellular response to hydrogen peroxide	GO:070301	10.0	F3, IL6, IL18
14	fibrinolysis	GO:042730	10.0	PROS1, PLAT, F2, SERPINE1
15	negative regulation of blood coagulation	GO:030195	9.9	SERPINE1, APOH, EDN1, THBD
16	blood coagulation, intrinsic pathway	GO:007597	9.9	F2, APOH, VWF
17	positive regulation of blood coagulation	GO:030194	9.9	F2, APOH, SERPINE1
18	negative regulation of fibrinolysis	GO:051918	9.9	SERPINE1, APOH, F2, THBD
19	positive regulation of angiogenesis	GO:045766	9.9	ADM, CX3CR1, F3, IL1B, SERPINE1
20	platelet degranulation	GO:002576	9.8	PROS1, F5, FGA, SERPINE1, SELP, VWF
21	regulation of vascular endothelial growth factor production	GO:010574	9.8	IL6, CCL2
22	positive regulation of protein phosphorylation	GO:001934	9.8	ADIPOQ, F2, IL1B, CD40
23	leukocyte migration	GO:050900	9.8	PROS1, THBD, F2, ICAM1, SELP
24	response to glucocorticoid stimulus	GO:051384	9.7	ADIPOQ, ADM, PLAT, CCL2, IL6, IL1B
25	MAPK cascade	GO:000165	9.5	IL18, IL1B, CCL2, CCR5
26	aging	GO:007568	9.5	ADM, TSPO, F3, CCL2, IL1B, VCAM1
27	cell adhesion	GO:007155	9.5	CX3CR1, ICAM1, F5, CCL2, VCAM1, SELP
28	chemokine-mediated signaling pathway	GO:070098	9.4	CX3CR1, CCR5, CCL2
29	response to hypoxia	GO:001666	9.2	ADIPOQ, ADM, EDN1, PLAT, CRP, CCL2
30	cellular response to lipopolysaccharide	GO:071222	9.1	CX3CR1, TSPO, ICAM1, CCR5, CCL2, SERPINE1
31	platelet activation	GO:030168	9.1	IL6, F5, F2, PROS1, FGA, CD40
32	blood coagulation	GO:007596	8.8	PROS1, THBD, PLAT, F2, F3, F5
33	inflammatory response	GO:006954	8.4	SELE, CRP, CYBA, CCR5, CCL2, IL6

Molecular functions related to arterial occlusive disease according to GeneDecks:

(show all 7)

id	Name	GO ID	Score	Top Affiliating Genes
1	sialic acid binding	GO:033691	10.2	ADIPOQ, SELP, SELE
2	oligosaccharide binding	GO:070492	10.0	SELE, SELP
3	eukaryotic cell surface binding	GO:043499	9.7	SELP, FGA, APOH, ADIPOQ
4	receptor binding	GO:005102	9.6	ADM, F2, CCL2, FGA, SERPINE1, ADIPOQ
5	protease binding	GO:002020	9.6	SERPINC1, SERPINE1, F3
6	cytokine activity	GO:005125	9.4	CD40LG, ADIPOQ, OSM, EDN1, IL6, IL1B
7	protein binding	GO:005515	4.3	CRP, PLAT, NOTCH3, NOTCH4, ACE, THBD