MCID: ART021
MIFTS: 63

Arteriosclerosis malady

Cardiovascular category

Summaries for Arteriosclerosis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Arteriosclerosis refers to a thickening and hardening of arterial walls in the arteries.... more...

MalaCards: Arteriosclerosis, also known as arteriosclerotic vascular disease nos, is related to arteriosclerosis obliterans and atherosclerosis. An important gene associated with Arteriosclerosis is KL (klotho), and among its related pathways are Signaling by GPCR and TNF signaling pathway. The drugs isoxsuprine and epoprostenol and the compounds prostacyclin and atorvastatin have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are cardiovascular system and homeostasis/metabolism.

Aliases & Classifications for Arteriosclerosis

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

arteriosclerosis 8 45 61
arteriosclerotic vascular disease nos 8
arteriosclerotic vascular disease 8
arteriosclerosis nos 8


External Ids:

Disease Ontology8 DOID:2349
MeSH35 D001161
NCIt40 C34398

Related Diseases for Arteriosclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Arteriosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 229)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis obliterans31.5SELP, VCAM1, PTGIR, PF4, ICAM1, HGF
2atherosclerosis30.7CCL2, ICAM1, ADIPOQ, SELP, VCAM1, PTGIR
3vascular disease30.5MGP, SELP, PF4
4coronary artery disease,30.3CCL2, ADIPOQ, SELP, VCAM1, PF4, AHSP
5coronary heart disease30.1APOA1, APOB, MGP, EDN1, AHSP, PF4
6uremia30.1ADIPOQ, VCAM1, PF4
7vasculitis30.1CCL2, ICAM1, VCAM1, SELP
8hyperhomocysteinemia30.1SELP, VCAM1, CCL2
9intermittent claudication30.1PF4, SELP
10systemic lupus erythematosus30.1CCL2, ICAM1, CD2, VCAM1
11hypercholesterolemia30.0APOA1, APOB, EDN1, AHSP, VCAM1, SELP
12acute myocardial infarction30.0SELP, PF4, AHSP, EDN1, APOB, APOA1
13insulin resistance30.0CCL2, APOA1, APOB, EDN1, CD2, VCAM1
14peripheral vascular disease30.0CCL2, VCAM1, SELP
15antiphospholipid syndrome29.8PF4, VCAM1, SELP
16thromboembolism29.8SELP, PF4, APOA1
17arcus senilis29.7APOB, APOA1
18thrombophilia29.7PF4, SELP
19blood platelet disease29.7PF4, SELP
20cadasil29.7APOB, CD63, PF4, SELP
21cerebral arteriosclerosis10.9
22thromboangiitis obliterans10.3
23aortic aneurysm10.2
24homocysteinemia10.1
25cytomegalovirus infection10.1
26angina pectoris10.1
27coronary aneurysm10.1
28monckeberg arteriosclerosis10.1
29nephrosclerosis10.1
30cerebral amyloid angiopathy10.1
31coronary thrombosis10.1
32bronchopneumonia10.1
33aortic disease10.1
34coronary artery aneurysm10.1
35hypertensive encephalopathy10.0
36abdominal aortic aneurysm10.0
37hypervitaminosis a10.0
38n syndrome10.0
39aneurysm disease10.0
40char syndrome10.0
41fish-eye disease10.0
42pyridoxine deficiency10.0
43spinal cord infarction10.0
44lip disease10.0
45diabetes mellitus10.0ADIPOQ, SELP, VCAM1, PF4, EDN1, MGP
46essential hypertension10.0ADIPOQ, SELP, PF4, AHSP, CD2, EDN1
47rheumatoid arthritis10.0CCL2, ICAM1, APOA1, PF4, VCAM1, SELP
48myocardial infarction10.0ADIPOQ, SELP, PF4, AHSP, CD2, EDN1
49proliferative diabetic retinopathy10.0HGF, CCL2, ICAM1, EDN1, VCAM1, SELP
50hypertension10.0CCL2, VCAM1, PTGIR, EDN1, APOB, APOA1

Graphical network of the top 20 diseases related to Arteriosclerosis:



Diseases related to arteriosclerosis

Clinical Features for Arteriosclerosis

Drugs & Therapeutics for Arteriosclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arteriosclerosis

Drug clinical trials:

Search ClinicalTrials for Arteriosclerosis

Search NIH Clinical Center for Arteriosclerosis

Search CenterWatch for Arteriosclerosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Arteriosclerosis

Anatomical Context for Arteriosclerosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Arteriosclerosis:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Spleen, Bone marrow, Whole blood, Heart, Smooth muscle, Small intestine, Colon, Pancreas, Prostate, Monocytes, T cells, B cells, Endothelial, Cardiac myocytes

Animal Models for Arteriosclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Arteriosclerosis

Sources:
51PubMed
See all sources

Articles related to Arteriosclerosis:

(show top 50)    (show all 938)
idTitleAuthorsYear
1
A new synthetic FGF receptor antagonist inhibits arteriosclerosis in a mouse vein graft model and atherosclerosis in apolipoprotein E-deficient mice. (24224032)
2013
2
Atherosclerosis and arteriosclerosis parameters in stroke patients associate with paraoxonase polymorphism and esterase activities. (23305304)
2013
3
Feasibility of Microvascular Head and Neck Reconstruction in the Setting of Calcified Arteriosclerosis of the Vascular Pedicle. (23277100)
2012
4
Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. (22723442)
2012
5
Editorial comment on "can the occurrence of gi bleeding in non-pulsatile LVAD patients provide clues for the reversal of arteriosclerosis?". (22062217)
2011
6
Influence of serum high-molecular-weight and total adiponectin on arteriosclerosis in IgA nephropathy patients. (18332637)
2008
7
Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis. (18802315)
2008
8
Increased arterial augmentation and augmentation index as surrogate parameters for arteriosclerosis in subjects with diabetes mellitus and nondiabetic subjects with cardiovascular disease. (19888415)
2007
9
Efficacy of low-density lipoprotein apheresis in arteriosclerosis obliterans of the lower extremities: two cases with marked alleviation of clinical symptoms. (17610290)
2007
10
Effects of angiotensin II on connexin 43 of VSMCs in arteriosclerosis. (16845719)
2006
11
Synergistic suppression of rat neointimal hyperplasia by rapamycin and imatinib mesylate: implications for the prevention of accelerated arteriosclerosis. (16410681)
2006
12
Experimental models of graft arteriosclerosis. (16790861)
2006
13
Antisense ERK1/2 oligodeoxynucleotide gene therapy attenuates graft arteriosclerosis of aortic transplant in a rat model. (17175255)
2006
14
MMP-2 expression is associated with rapidly proliferative arteriosclerosis in the flexor tenosynovium and pain severity in carpal tunnel syndrome. (15685708)
2005
15
Allogenic immune response promotes the accumulation of host-derived smooth muscle cells in transplant arteriosclerosis. (15639493)
2005
16
Effect of pioglitazone on arteriosclerosis in comparison with that of glibenclamide. (15860237)
2005
17
Lipoprotein oxidation products and arteriosclerosis: theory and methods with applicability to the clinical chemistry laboratory. (15521187)
2004
18
Platelet activation markers, microparticles and soluble adhesion molecules are elevated in patients with arteriosclerosis obliterans: therapeutic effects by cilostazol and potentiation by dipyridamole. (15203718)
2004
19
Pravastatin decreases cold ischemia--but not alloantigen-dependent transplant arteriosclerosis. (14697993)
2003
20
Platelet scintigraphy in the diagnosis of arteriosclerosis obliterans. (12376783)
2002
21
Impairment of cytolytic activity in allograft environment affects early medial cell loss but does not alter outcome of allograft arteriosclerosis. (11250234)
2001
22
Fatal lipid embolism following intraarterial angiography at an early stage of arteriosclerosis. (11271906)
2000
23
Inducible expression of BTEB2, a member of the zinc-finger family of transcription factors, in cardiac allograft arteriosclerosis. (11120052)
2000
24
Homocysteine and arteriosclerosis: established risk factor or new illusion? (11304646)
2000
25
Arteriosclerosis in rat aortic allografts: early changes in endothelial integrity and smooth muscle phenotype. (10919577)
2000
26
Prevention of cardiac allograft arteriosclerosis by protein tyrosine kinase inhibitor selective for platelet-derived growth factor receptor. (10226096)
1999
27
Donor and recipient contributions of ICAM-1 and P-selectin in parenchymal rejection and graft arteriosclerosis: insights from double knockout mice. (10512519)
1999
28
Inhibitory effect of 15-deoxyspergualin on coronary arteriosclerosis in the transplanted heart. (10083050)
1999
29
An experimental model of ischemia-produced transplant arteriosclerosis. (9636412)
1998
30
Common pathways in allograft arteriosclerosis and experimental vascular injury: new potential sites of inhibition. (9595058)
1998
31
MRA imaging of arterial patency in undialyzed uremic patients with arteriosclerosis obliterans. (8771247)
1995
32
Beneficial results of pentoxifylline ('Trental') therapy in arteriosclerosis obliterans: possible mechanism of action. (3886306)
1985
33
Coronary artery ectasia--a variant of occlusive coronary arteriosclerosis. (646906)
1978
34
Ankle:arm systolic blood pressure ratio. Diagnostic significance in arteriosclerosis obliterans. (275614)
1978
35
Quantitative detection of cerebral arteriosclerosis by means of the pressure-velocity hysteresis technique. (966362)
1976
36
A comparison of three methods of detecting ventricular incoordination in man, and the relation of their results to the amount of coronary arteriosclerosis. (985338)
1976
37
The value of roentgenographic abdominal aortic calcification in predicting site of occlusion in arteriosclerosis obliterans. (5018613)
1972
38
Long-term management of symptoms of cerebral arteriosclerosis. (4253476)
1971
39
Paradoxical effect on peripheral blood flow after sympathetic blockades in patients with gangrene due to arteriosclerosis obliterans. (5122534)
1971
40
Basophil leukocytes in arteriosclerosis obliterans. (5727931)
1968
41
SIGNIFICANCE OF CORONARY ARTERIOSCLEROSIS IN THE INTRAMUSCULAR CORONARY ARTERIES. (14261244)
1965
42
The diagnosis of cerebral arteriosclerosis. (13989662)
1963
43
Accelerated thromboplastin generation in acute arterial occulusion complicating arteriosclerosis obliterans. (13915850)
1961
44
Experimental arteriosclerosis due to hypervitaminosis D. (13712151)
1960
45
The selection of patients for arterial grafting in peripheral arteriosclerosis obliterans. (13488194)
1957
46
Chronic subdural hematoma in the guise of cerebral arteriosclerosis. (13334834)
1956
47
Pathologic lesions in chronic cases of cerebral arteriosclerosis. (14368160)
1955
48
Cerebral arteriosclerosis and the so-called presenile scleroses. (13242345)
1955
49
The effect of nicotinic acid and pentylenetetrazol in the therapy of psychiatric symptoms of cerebral arteriosclerosis. (13236117)
1954
50
Sympathectomy for arteriosclerosis obliterans; rationale and results. (18934297)
1948

Genetic Variations for Arteriosclerosis

Expression for genes affiliated with Arteriosclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arteriosclerosis

Search GEO for disease gene expression data for Arteriosclerosis.

Pathways for genes affiliated with Arteriosclerosis

Sources:
54Reactome, 30KEGG, 52QIAGEN, 38NCBI BioSystems Database
See all sources

Pathways related to Arteriosclerosis according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5KL, CCL2, ICAM1, PDGFB, APOA1, APOB
210.5VCAM1, EDN1, ICAM1, CCL2
310.5SELP, VCAM1, CD2, ICAM1
410.5ICAM1, APOA1, VCAM1
5
Hide members
10.5HGF, CCL2, PDGFB, PTGIR, VCAM1
610.5CCL2, ICAM1, VCAM1
710.5CCL2, ICAM1, APOA1, APOB
810.5ICAM1, APOB, SELP
910.5SELP, CD2, APOB
10
Hide members
10.5CD2, PDGFB, HGF
11
Hide members
10.5SELP, PF4, CD63, APOA1, PDGFB, HGF
1210.5APOB, APOA1
13
Hide members
10.5HGF, PDGFB, APOA1, APOB, CD2, CD63
1410.5PTGIR

Compounds for genes affiliated with Arteriosclerosis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Arteriosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 178)
idCompoundScoreTop Affiliating Genes
1prostacyclin4511.0SELP, ADIPOQ, VCAM1, PTGIR, HGF, ICAM1
2atorvastatin45 50 29 11 2415.0ADIPOQ, VCAM1, APOB, EDN1, APOA1, ICAM1
3fibrinogen4511.0ADIPOQ, CCL2, PF4, ICAM1, APOA1, APOB
4fenofibrate45 50 1113.0APOB, ADIPOQ, SELP, ICAM1, APOA1, VCAM1
5pravastatin45 50 29 11 2415.0ICAM1, ADIPOQ, APOB, SELP, VCAM1, CCL2
6homocysteine45 2411.9VCAM1, APOB, AHSP, CCL2, APOA1, SELP
7aspirin45 50 29 2413.9APOB, SELP, PF4, DUSP2, CD63, HGF
8dextran sulfate4510.9HGF, ICAM1, APOA1, APOB, SELP, PF4
9lactate4510.9VCAM1, HGF, ICAM1, APOA1, APOB, CD63
10vegf4510.9ICAM1, VCAM1, KL, HGF, EDN1, CCL2
11lipid4510.9APOB, APOA1, HGF, CD2, CD63, AHSP
12simvastatin45 50 60 29 11 2415.9CCL2, ICAM1, APOB, VCAM1, SELP, ADIPOQ
13fluvastatin45 50 29 1113.9SELP, VCAM1, APOB, CCL2, ICAM1, APOA1
14cholesterol45 29 11 2413.9APOB, MGP, CD63, PF4, VCAM1, SELP
15pge24510.9PF4, AHSP
16histamine45 29 2412.9CCL2, SELP, VCAM1, PF4, AHSP, EDN1
17rantes4510.9PF4, ICAM1
18probucol45 1111.9VCAM1, EDN1, CCL2, APOA1, APOB
19losartan45 50 29 1113.9EDN1, HGF, VCAM1, CCL2, ADIPOQ, SELP
20cilostazol45 1111.9HGF, VCAM1, CCL2, PF4
21genistein45 29 60 2 11 2415.9ICAM1, CCL2, EDN1, HGF, APOB, VCAM1
228-isoprostane4510.9ADIPOQ, EDN1, ICAM1, CCL2, VCAM1
23sodium nitroprusside4510.9AHSP, SELP, VCAM1, ADIPOQ, HGF, EDN1
24norepinephrine45 11 2412.9AHSP
25iloprost45 60 29 1113.9PTGIR, SELP, EDN1, VCAM1, PF4
26thromboxane a245 2411.9PF4, PTGIR, SELP, EDN1, AHSP, CD63
27pdmp4510.9CD63, DUSP2, ICAM1, SELP
28fenofibric acid45 2911.9CCL2, APOB, ADIPOQ, APOA1
29polysaccharide4510.8HGF, CCL2, ICAM1, APOB, PF4, SELP
30dexamethasone45 50 29 1113.8ADIPOQ, PDGFB, HGF
31phosphatidylinositol4510.8DUSP2, ADIPOQ, HGF, CCL2, ICAM1, EDN1
32creatinine4510.8APOA1, APOB, SELP, ADIPOQ
33glucose4510.8CD63, APOA1, AHSP, PF4, CD2
34nitric oxide45 11 2412.8AHSP, ICAM1, PDGFB, EDN1, CD63, PTGIR
35thromboxane45 2411.8PF4, PTGIR, AHSP, EDN1, SELP
36adenylate4510.8APOB, HGF, PF4, PTGIR, VCAM1, SELP
37valsartan45 60 29 1113.8ADIPOQ, SELP, EDN1, CCL2
38isoproterenol45 1111.8AHSP, PTGIR, VCAM1, EDN1, APOB, CCL2
39wortmannin4510.8ADIPOQ, HGF, PF4, CD63, CD2, CCL2
40pioglitazone45 50 29 1113.7CCL2, ADIPOQ, VCAM1, APOA1, APOB
41tyrosine4510.7CD63, SELP, VCAM1, MCAM, CD2, DUSP2
42mdmp4510.7DUSP2, CD63, SELP
43calcium45 50 11 2413.7CD2, EDN1, DUSP2, MCAM, PF4, AHSP
44arachidonic acid45 29 11 2413.6PTGIR, PF4, AHSP, CD63, EDN1, HGF
45cuprophan4510.6ICAM1, VCAM1, SELP, PF4
46estrogen4510.5AHSP, MGP
47enalapril45 50 1112.5ADIPOQ, EDN1, HGF, APOA1
48cerivastatin45 50 29 1113.5APOB, APOA1, ICAM1, CCL2
49arginine4510.4AHSP, PF4, VCAM1, SELP, EDN1, CCL2
50sb 20358045 6011.2ICAM1, CCL2, EDN1, VCAM1, ADIPOQ, HGF

GO Terms for genes affiliated with Arteriosclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Arteriosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.7ADIPOQ, KL, HGF, CCL2, ICAM1, PDGFB
2extracellular regionGO:00557610.6PDGFB, CCL2, HGF, KL, APOA1, APOB
3plasma membraneGO:00588610.5ICAM1, APOA1, APOB, CD2, CD63, MCAM
4external side of plasma membraneGO:00989710.5ICAM1, CD2, MCAM, VCAM1, SELP
5platelet alpha granule lumenGO:03109310.4HGF, PDGFB, PF4
6platelet dense granule membraneGO:03108810.2SELP, CD63

Biological processes related to Arteriosclerosis according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1blood coagulationGO:00759610.9SELP, HGF, PDGFB, APOA1, APOB, CD2
2cellular response to tumor necrosis factorGO:07135610.9EDN1, APOB, ICAM1, CCL2
3response to hypoxiaGO:00166610.9CCL2, PDGFB, EDN1, VCAM1, ADIPOQ
4platelet degranulationGO:00257610.9HGF, PDGFB, APOA1, CD63, PF4, SELP
5platelet activationGO:03016810.9HGF, PDGFB, APOA1, CD63, PF4, SELP
6response to amino acid stimulusGO:04320010.9CCL2, ICAM1, EDN1
7leukocyte cell-cell adhesionGO:00715910.9ICAM1, VCAM1, SELP
8leukocyte migrationGO:05090010.9ICAM1, APOB, CD2, SELP
9response to lipopolysaccharideGO:03249610.9SELP, PTGIR, EDN1, APOB
10heterophilic cell-cell adhesionGO:00715710.9ICAM1, VCAM1, SELP
11cellular response to interleukin-1GO:07134710.8EDN1, ICAM1, CCL2
12organ regenerationGO:03110010.8HGF, CCL2, APOA1
13positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.8SELP, PDGFB, HGF
14lipoprotein biosynthetic processGO:04215810.8APOA1, APOB
15membrane to membrane dockingGO:02261410.8ICAM1, VCAM1
16cell adhesionGO:00715510.8SELP, VCAM1, MCAM, ICAM1, CCL2
17maternal process involved in parturitionGO:06013710.8CCL2, EDN1
18negative regulation of heterotypic cell-cell adhesionGO:03411510.8APOA1, ADIPOQ
19negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.8ADIPOQ, PTGIR
20negative regulation of tumor necrosis factor-mediated signaling pathwayGO:01080410.8ADIPOQ, APOA1
21cytokine-mediated signaling pathwayGO:01922110.7CCL2, ICAM1, PF4, VCAM1
22positive regulation of peptidyl-tyrosine phosphorylationGO:05073110.7HGF, PDGFB, ADIPOQ
23response to nutrientGO:00758410.7APOA1, VCAM1, ADIPOQ
24positive regulation of DNA biosynthetic processGO:200057310.7HGF, PDGFB
25low-density lipoprotein particle clearanceGO:03438310.7APOB, ADIPOQ
26response to ethanolGO:04547110.6ADIPOQ, ICAM1, CCL2
27negative regulation of hormone secretionGO:04688810.6ADIPOQ, EDN1
28leukocyte tethering or rollingGO:05090110.6VCAM1, SELP
29response to drugGO:04249310.5APOA1, PDGFB, ICAM1, CCL2
30cholesterol transportGO:03030110.5APOB, APOA1
31agingGO:00756810.4KL, CCL2, VCAM1
32acute inflammatory responseGO:00252610.2VCAM1, KL

Molecular functions related to Arteriosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heparin bindingGO:00820110.5SELP, PF4, APOB, CCL2
2cholesterol transporter activityGO:01712710.5APOB, APOA1
3sialic acid bindingGO:03369110.4SELP, ADIPOQ
4hormone activityGO:00517910.2ADIPOQ, EDN1, KL

Products for genes affiliated with Arteriosclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arteriosclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet