MCID: ART008
MIFTS: 53

Arteriosclerosis Obliterans malady

Summaries for Arteriosclerosis Obliterans

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63Wikipedia, 32MalaCards
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Wikipedia:63 Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal... more...

MalaCards: Arteriosclerosis Obliterans is related to arteriosclerosis and hypertension. An important gene associated with Arteriosclerosis Obliterans is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Thromboxane A2 receptor signaling and Malaria. The drugs tolazoline and tolazoline hydrochloride and the compounds cycloheximide and losartan have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Arteriosclerosis Obliterans

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

arteriosclerosis obliterans 8 10 44 60


External Ids:

Disease Ontology8 DOID:5160
SNOMED-CT56 60625000, 361133006
MeSH34 D001162

Related Diseases for Arteriosclerosis Obliterans

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Arteriosclerosis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.9HGF, VCAM1, EDN1, ICAM1, ADIPOQ
2hypertension30.8ICAM1, VCAM1, PTGIR, ACE, EDN1
3diabetes mellitus30.7ADIPOQ, EDN1, SELP, ACE, PF4, VCAM1
4ischemia30.5FGF2, SELP, PF4, EDN1, ITGAL, ICAM1
5intermittent claudication30.4FGF2, PF4, SELP
6ischemic heart disease30.3PF4, EDN1, ACE, SELP
7myocardial infarction30.3ITGAL, ANXA5, CD2, PF4, ACE, SELP
8atherosclerosis30.3SELP, VCAM1, ACE, FGF2, PF4, ADIPOQ
9lupus erythematosus30.1ANXA5
10blood platelet disease30.1PF4, SELP
11peripheral vascular disease30.1SELP, VCAM1
12systemic lupus erythematosus30.1VCAM1, CD2, ANXA5, ITGA4, ICAM1, ITGAL
13essential hypertension30.1SELP, ADIPOQ, ACE, PF4, CD2, EDN1
14coronary artery disease30.1ACE, ICAM1, ADIPOQ, VCAM1, SELP, PF4
15type 2 diabetes mellitus30.1VCAM1, CD63, DUSP2, EDN1, ACE, ADIPOQ
16vascular disease30.1VCAM1, ACE, ADIPOQ, ICAM1, SELP, FGF2
17thromboangiitis obliterans10.5
18aortic aneurysm10.4
19coronary arteriosclerosis10.3
20cerebritis10.3
21aneurysm disease10.3
22aortic disease10.3
23wrinkles10.1
24coronary aneurysm10.1
25abdominal aortic aneurysm10.1
26heart aneurysm10.1
27purpura10.1
28ruptured aortic aneurysm10.1
29thrombophlebitis10.1
30venous insufficiency10.1
31peritonitis10.0SELP
32obesity10.0ADIPOQ
33hepatitis10.0HGF
34galactosemia10.0ICAM1
35biliary atresia10.0HGF
36myopathy10.0TPM1
37myeloid leukemia10.0ITGAL
38hypertrophic cardiomyopathy10.0TPM1
39proliferative glomerulonephritis10.0SELP
40polycystic ovary syndrome10.0ADIPOQ
41respiratory failure10.0ICAM1
42migraine10.0ITGAL
43severe pre-eclampsia10.0VCAM1
44hepatitis c10.0ANXA5
45sarcoma10.0ITGA4
46crohn's disease10.0ITGA4
47carotid stenosis10.0SELP
48thromboembolism10.0SELP, PF4
49acute leukemia10.0ITGA4
50coronary stenosis10.0SELP, ADIPOQ

Graphical network of the top 20 diseases related to Arteriosclerosis Obliterans:



Diseases related to arteriosclerosis obliterans

Clinical Features for Arteriosclerosis Obliterans

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Drugs & Therapeutics for Arteriosclerosis Obliterans

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Arteriosclerosis Obliterans

Drug clinical trials:

Search ClinicalTrials for Arteriosclerosis Obliterans

Search NIH Clinical Center for Arteriosclerosis Obliterans

Search CenterWatch for Arteriosclerosis Obliterans

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Arteriosclerosis Obliterans

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Anatomical Context for Arteriosclerosis Obliterans

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32MalaCards
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MalaCards organs/tissues related to Arteriosclerosis Obliterans:

32
Heart, Bone marrow, Bone, Skin, Spleen, Smooth muscle, Endothelial

Animal Models for Arteriosclerosis Obliterans or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Arteriosclerosis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5ICAM1, ITGAL, PTGIR
2MP:00053848.0ICAM1, ITGA4, ITGAL, CD44, FGF2, ACE
3MP:00053977.6CD44, ITGAL, ITGA4, ICAM1, HGF, PF4
4MP:00053857.5TPM1, HGF, ICAM1, EDN1, ITGA4, CD44
5MP:00107687.5HGF, ICAM1, EDN1, ITGA4, CD44, FGF2
6MP:00053877.3DUSP2, ANXA5, ITGAL, ITGA4, ICAM1, CD44
7MP:00053766.7CD63, CD44, ITGAL, EDN1, ICAM1, PF4

Publications for Arteriosclerosis Obliterans

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50PubMed
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Articles related to Arteriosclerosis Obliterans:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
The efficacy of oral beraprost sodium, a prostaglandin I2 analogue, for treating intermittent claudication in patients with arteriosclerosis obliterans. (20357749)
2010
2
Characteristics of revascularization treatment for arteriosclerosis obliterans in patients with and without hemodialysis. (20938099)
2010
3
Arteriosclerosis obliterans associated with anti-cardiolipin antibody/beta2-glycoprotein I antibodies as a strong risk factor for ischaemic heart disease in patients with systemic lupus erythematosus. (18375400)
2008
4
Randomised comparison of G-CSF-mobilized peripheral blood mononuclear cells versus bone marrow-mononuclear cells for the treatment of patients with lower limb arteriosclerosis obliterans. (18064333)
2007
5
Quality of life improvement and long-term effects of peripheral blood mononuclear cell transplantation for severe arteriosclerosis obliterans in diabetic patients on dialysis. (17652880)
2007
6
Three cases of ischemic ulcer due to arteriosclerosis obliterans responding to basic fibroblast growth factor spray. (15372302)
2004
7
Platelet activation markers, microparticles and soluble adhesion molecules are elevated in patients with arteriosclerosis obliterans: therapeutic effects by cilostazol and potentiation by dipyridamole. (15203718)
2004
8
Platelet-derived microparticles in patients with arteriosclerosis obliterans: enhancement of high shear-induced microparticle generation by cytokines. (10822072)
2000
9
The exercise pressor reflex and changes in radial arterial pressure and heart rate during walking in patients with arteriosclerosis obliterans. (10348424)
1999
10
Ruptured distal aortic arch aneurysm associated with arteriosclerosis obliterans. (10074572)
1999
11
Hemodynamic changes in the lower limbs during treadmill walking in normal subjects and in patients with arteriosclerosis obliterans. (9313629)
1997
12
Effect of elastase on primary graft patency after femoralpopliteal arterial bypass for arteriosclerosis obliterans: a randomized, controlled study. (9189814)
1997
13
A rare case of arteriosclerosis obliterans without prominent risk factors complicated by idiopathic thrombocytopenic purpura. A case report. (8619516)
1996
14
Six year experience with wrinkled ePTFE vascular prostheses for arteriosclerosis obliterans. (8268590)
1993
15
Arteriosclerosis obliterans in a rabbit model. (1473925)
1992
16
Beneficial effects of eicosapentaenoic acid for diabetic patients with arteriosclerosis obliterans. (1478154)
1992
17
Comparison of arteriosclerosis obliterans of lower limbs between China and Japan. (2225282)
1990
18
The effect of Etofibrate (Lipo-Merz) on "in vitro" cellular immune response and on lipid parameters of men with myocardial infarction and with arteriosclerosis obliterans. (2371944)
1990
19
Management alternatives of infrainguinal arteriosclerosis obliterans in the elderly. (3952603)
1986
20
The effect of HR (O-Beta-Hydroxyethylo-Rutoside, Venoruton) on the deformability of erythrocytes in patients with arteriosclerosis obliterans of lower limbs. (2581865)
1985
21
Systolic hypertension in arteriosclerosis obliterans of the lower limbs. (6811168)
1982
22
Arteriosclerosis obliterans and associated risk factors in insulin-dependent and non-insulin-dependent diabetes. (7429028)
1980
23
Successful therapy of advanced arteriosclerosis obliterans with prostacyclin. (86835)
1979
24
The correlation of arteriosclerosis obliterans with lipoproteins in insulin-dependent and non-insulin-dependent diabetes. (467809)
1979
25
Fibrinolysis and kinin system activity of venous and arterial blood in patients suffering from arteriosclerosis obliterans. (1231761)
1975
26
Saphenous vein bypass grafts for arteriosclerosis obliterans in the femoropopliteal region. (4695292)
1973
27
Cigarette smoking and arteriosclerosis obliterans: an epidemiologic approach. (5007359)
1972
28
The value of roentgenographic abdominal aortic calcification in predicting site of occlusion in arteriosclerosis obliterans. (5018613)
1972
29
Peripheral arterial insufficiency. An epidemiological study of 2,243 hospital admissions caused by arteriosclerosis obliterans, diabetes mellitus, thrombangitis obliterans and arterial embolism. (5291650)
1971
30
Basophil leukocytes in arteriosclerosis obliterans. (5727931)
1968
31
Lumbar sympathectomy: a procedure of questionable value in the treatment of arteriosclerosis obliterans of the legs. (4879511)
1968
32
A diagnostic aid for determining peripheral arteriosclerosis obliterans. (6058444)
1967
33
CLINICAL AND PLETHYSMOGRAPHIC OBSERVATIONS ON THE USE OF CYCLANDELATE IN ARTERIOSCLEROSIS OBLITERANS. (14124708)
1964
34
FEMOROPOPLITEAL ARTERIOSCLEROSIS OBLITERANS--ARTERIOGRAPHIC PATTERNS AND RATES OF PROGRESSION. (14114258)
1964
35
Lumbar sympathectomy for arteriosclerosis obliterans. (13971436)
1963
36
Studies on the peripheral circulation and metabolism in man. II. Oxygen utilization and lactate-pyruvate formation in the legs at rest and during exercise in patients with arteriosclerosis obliterans. (13876645)
1962
37
Treatment of diabetic ulcer with concomitant arteriosclerosis obliterans. (14424139)
1960
38
Arteriosclerosis obliterans: review of 520 cases with special reference to pathogenic and prognostic factors. (14408094)
1960
39
Arteriosclerosis obliterans of the lower extremity. (13620974)
1959
40
Oxygen utilization and lactic acid formation in the legs at rest and during exercise in normal subjects and in patients with arteriosclerosis obliterans. (13660772)
1959
41
Arteriosclerosis obliterans; its surgical repair. (13587281)
1958
42
The selection of patients for arterial grafting in peripheral arteriosclerosis obliterans. (13488194)
1957
43
Evaluation of thrombendarterectomy for arteriosclerosis obliterans of the femoral artery. (13433254)
1957
44
Coronary (ischaemic) heart disease in patients with arteriosclerosis obliterans. (13394194)
1956
45
An approach to the etiology, diagnosis and management of peripheral arteriosclerosis (arteriosclerosis obliterans). (13318639)
1956
46
Incidence of segmental occlusion in peripheral arteriosclerosis obliterans. (13212286)
1954
47
Arteriosclerosis obliterans involving the upper limbs: case report. (14815075)
1951
48
Arteriosclerosis obliterans as a cause of ulcer of the leg. (15398743)
1950
49
Management of arteriosclerosis obliterans in cold climates. (14774636)
1950
50
Histidine and ascorbic acid treatment of arteriosclerosis obliterans with radioactive isotope estimations of circulatory effects. (18890449)
1948

Genetic Variations for Arteriosclerosis Obliterans

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Expression for genes affiliated with Arteriosclerosis Obliterans

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arteriosclerosis Obliterans

Search GEO for disease gene expression data for Arteriosclerosis Obliterans.

Pathways for genes affiliated with Arteriosclerosis Obliterans

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Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN
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Pathways related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PTGIR
210.0ITGAL
39.8CD2, CD44, ITGA4
49.7EDN1, ANXA5, PTGIR
5
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9.7HGF, ICAM1, CD44, VCAM1
69.6ICAM1, ITGA4, CD44, VCAM1
79.6ICAM1, ITGAL, SELP
89.4VCAM1, ITGAL, ITGA4, ICAM1
99.4VCAM1, ITGAL, ITGA4, ICAM1
109.4ITGA4, ITGAL, CD2, SELP
11
Hide members
9.4HGF, FGF2, ACE, PTGIR, VCAM1
12
Hide members
9.3SELP, PF4, CD63, HGF
13
Hide members
9.3ITGA4, ITGAL, CD44, VCAM1
14
Hide members
9.1FGF2, CD2, ITGAL, ITGA4, HGF
15
Hide members
9.0ICAM1, ITGA4, ITGAL, PF4, VCAM1
169.0ICAM1, ITGA4, ITGAL, CD2, VCAM1, SELP
178.9HGF, MIR21, CD44, CD63, FGF2
18
Hide members
8.8ICAM1, ITGA4, ITGAL, CD44, FGF2, VCAM1
19
Hide members
8.8HGF, ICAM1, ITGA4, ITGAL, CD44, FGF2
20
Hide members
8.8HGF, ITGA4, ITGAL, CD44, FGF2, PTGIR
21
Hide members
8.8HGF, ITGA4, ITGAL, CD2, PF4, FGF2
22
Hide members
8.6HGF, ITGA4, ITGAL, CD2, CD63, PF4
23
Hide members
8.3ICAM1, EDN1, ITGA4, ITGAL, PF4, FGF2

Compounds for genes affiliated with Arteriosclerosis Obliterans

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
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Compounds related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5HGF
2losartan44 49 28 1113.2SELP, HGF, EDN1
3sele4410.0SELP, ACE, ICAM1, VCAM1
4pge2449.8PF4, CD44, ITGAL
5cilostazol44 1110.8HGF, PF4, VCAM1, SELP
6dermatan sulfate449.8FGF2, PF4, CD44, SELP
7valsartan44 59 28 1112.8EDN1, ACE, SELP, ADIPOQ
8slea449.7ITGA4, ICAM1, ITGAL, SELP
9tetramethylpyrazine449.7ICAM1, EDN1, ITGAL, SELP
10iloprost44 59 28 1112.7PTGIR, VCAM1, SELP, PF4, EDN1
11N,O6-Disulfo-Glucosamine119.7HGF, FGF2, ANXA5
12mdmp449.7ANXA5, DUSP2, CD63, SELP
13dextran sulfate449.7CD44, PF4, ICAM1, SELP, HGF
14pdmp449.5ICAM1, DUSP2, ANXA5, CD63, SELP
15cuprophan449.5ICAM1, PF4, VCAM1, ITGAL, SELP
16carbohydrates449.5ANXA5, CD44, FGF2, VCAM1, ADIPOQ, SELP
17fluvastatin44 49 28 1112.4ANXA5, SELP, VCAM1, ITGAL, ICAM1
18rantes449.4ICAM1, ITGA4, CD44, PF4, ITGAL
19slex449.4ITGA4, ICAM1, ITGAL, SELP, CD44, VCAM1
20pravastatin44 49 28 11 2413.4ADIPOQ, SELP, VCAM1, ITGAL, ICAM1
21sb 20358044 5910.3ANXA5, ICAM1, HGF, ADIPOQ, FGF2, EDN1
22simvastatin44 49 59 28 11 2414.3ADIPOQ, VCAM1, SELP, ANXA5, ICAM1, ITGAL
23dexamethasone44 49 28 1112.3FGF2, ANXA5, ITGAL, ITGA4, ADIPOQ, HGF
24polysaccharide449.2ICAM1, VCAM1, FGF2, SELP, PF4, CD44
25enalapril44 49 1111.2HGF, EDN1, ADIPOQ, ACE
26ly294002449.2ADIPOQ, CD44, SELP, VCAM1, FGF2, ANXA5
27thromboxane a244 2410.2CD63, SELP, PTGIR, PF4, EDN1
28cytochalasin d44 5910.2FGF2, ICAM1, ITGA4, ITGAL, VCAM1, CD44
29hyaluronic acid44 2410.2HGF, ICAM1, CD44, ITGAL, VCAM1, FGF2
30genistein44 28 59 2 11 2414.1ANXA5, FGF2, ITGA4, SELP, EDN1, ICAM1
31fmlp449.1ICAM1, ITGA4, ITGAL, PF4, VCAM1, SELP
32glucose449.0PF4, CD63, CD2, CD44, ITGA4
33adenylate448.9ADIPOQ, SELP, VCAM1, HGF, PTGIR, PF4
34heparin44 28 11 2411.8ADIPOQ, SELP, VCAM1, PF4, CD44, ANXA5
35actinomycin d448.7EDN1, ICAM1, FGF2, HGF, ADIPOQ, ITGAL
36lactate448.7ANXA5, ICAM1, SELP, HGF, PF4, CD44
37vegf448.7PF4, FGF2, ANXA5, SELP, CD44, VCAM1
38prostacyclin448.7ICAM1, EDN1, PF4, FGF2, ACE, PTGIR
39oxygen44 249.6ITGAL, ITGA4, ANXA5, CD44, PF4, ICAM1
40cyclosporin a44 28 5910.6SELP, FGF2, CD44, ANXA5, ITGAL, EDN1
41aspirin44 49 28 2411.4ADIPOQ, SELP, ACE, PF4, CD63, ITGAL
42retinoic acid44 249.4ADIPOQ, ITGA4, HGF, SELP, VCAM1, ICAM1
43wortmannin448.4ADIPOQ, VCAM1, PF4, ITGA4, HGF, ITGAL
44cholesterol44 28 11 2411.1SELP, ITGAL, PF4, CD63, ACE, VCAM1
45fibrinogen448.1SELP, CD63, DUSP2, PF4, ICAM1, VCAM1
46nitric oxide44 11 2410.1CD63, CD44, ITGAL, ITGA4, ICAM1, EDN1
47lipid447.8HGF, ACE, ADIPOQ, VCAM1, PTGIR, PF4
48phosphatidylinositol447.4DUSP2, HGF, ICAM1, ITGA4, ITGAL, EDN1
49tyrosine446.9MCAM, FGF2, HGF, ITGA4, ICAM1, ITGAL
50calcium44 49 11 249.7ITGA4, ITGAL, EDN1, PF4, ANXA5, TPM1

GO Terms for genes affiliated with Arteriosclerosis Obliterans

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16Gene Ontology
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Cellular components related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet dense granule membraneGO:0310889.6CD63, SELP
2cell surfaceGO:0099869.2ITGA4, CD44, CD63, VCAM1, ADIPOQ
3extracellular regionGO:0055768.7EDN1, CD2, PF4, FGF2, ACE, ADIPOQ
4extracellular spaceGO:0056158.5HGF, ICAM1, EDN1, PF4, FGF2, ACE
5external side of plasma membraneGO:0098977.9SELP, ICAM1, ITGA4, ITGAL, ANXA5, CD44
6plasma membraneGO:0058867.2ICAM1, ITGA4, ITGAL, CD44, CD2, CD63

Biological processes related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.3VCAM1, ICAM1
2negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.3ADIPOQ, PTGIR
3chorio-allantoic fusionGO:06071010.2VCAM1, ITGA4
4T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.0ICAM1, ITGAL
5hyaluronan catabolic processGO:03021410.0FGF2, CD44
6negative regulation of hormone secretionGO:0468889.9ADIPOQ, EDN1
7interferon-gamma-mediated signaling pathwayGO:0603339.9VCAM1, CD44, ICAM1
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8HGF, CD44, ADIPOQ
9leukocyte tethering or rollingGO:0509019.8SELP, VCAM1
10cytokine-mediated signaling pathwayGO:0192219.6ICAM1, CD44, PF4, VCAM1
11platelet degranulationGO:0025769.6HGF, CD63, PF4, SELP
12regulation of immune responseGO:0507769.6VCAM1, ITGAL, ITGA4, ICAM1
13platelet activationGO:0301689.5HGF, CD63, PF4, SELP
14leukocyte cell-cell adhesionGO:0071599.5ICAM1, ITGA4, ITGAL, VCAM1, SELP
15heterophilic cell-cell adhesionGO:0071579.5ICAM1, ITGA4, ITGAL, VCAM1, SELP
16leukocyte migrationGO:0509009.5SELP, CD2, ITGAL, ITGA4, ICAM1
17cell adhesionGO:0071559.2ICAM1, ITGAL, MCAM, VCAM1, SELP
18blood coagulationGO:0075968.3SELP, HGF, ITGA4, ITGAL, ANXA5, CD2

Molecular functions related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:03369110.1ADIPOQ, SELP
2protein bindingGO:0055156.6ADIPOQ, HGF, ICAM1, EDN1, ITGA4, ITGAL

Products for genes affiliated with Arteriosclerosis Obliterans

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arteriosclerosis Obliterans

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet