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Arteriosclerosis Obliterans malady
2 drugs, 20 genes, 4 tissues, 322 related diseases, 7 phenotypes, 13 articles, clinical trials.

Summaries for Arteriosclerosis Obliterans

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44Wikipedia, 22MalaCards
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Wikipedia: Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal...44 more...

MalaCards: Arteriosclerosis Obliterans, also known as arteriosclerosis obliterans (disorder), is related to ischemic heart disease and arteriosclerosis. An important gene associated with Arteriosclerosis Obliterans is PF4 (platelet factor 4), and among its related pathways are Staphylococcus aureus infection and Akt Signaling. The drugs tolazoline hydrochloride and tolazoline and the compounds tetramethylpyrazine and sele have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and smooth muscle, and related mouse phenotypes are hematopoietic system and immune system.

Aliases & Descriptions for Arteriosclerosis Obliterans

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6Disease Ontology, 8DISEASES, 32Novoseek , 43UMLS, 40SNOMED-CT, 24MeSH
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Aliases & Descriptions:

arteriosclerosis obliterans 6 8 32 43
arteriosclerosis obliterans (disorder) 6

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Related Diseases for Arteriosclerosis Obliterans

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13GeneCards, 14GeneDecks
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Diseases related to arteriosclerosis obliterans by text searches and GeneDecks gene sharing:

(show top 50)    (show all 319)
idRelated DiseaseScoreTop Affiliating Genes
1ischemic heart disease29.1SELP, PF4, EDN1, ACE
2arteriosclerosis26.6SELP, VCAM1, CD2, CD63, CD44, ITGA4
3hypertension22.5SELP, VCAM1, CD2, CD63, CD44, ITGAL
4mitral valve stenosis13.5SELP, PF4
5alcoholic hepatitis13.5ICAM1, HGF
6adult dermatomyositis13.5VCAM1, ICAM1
7lymphocytic vasculitis13.4VCAM1, ICAM1
8henoch-schoenlein purpura13.4VCAM1, ICAM1
9hyperlipoproteinemia type iii13.4VCAM1, ICAM1, PF4
10inclusion body myositis13.4VCAM1, ICAM1
11cerebral malaria13.3SELP, VCAM1, ICAM1
12severe pre-eclampsia13.3SELP, VCAM1, ADIPOQ
13von willebrand's disease13.3SELP, CD63, PF4
14blood platelet disease13.2SELP, PF4
15hypertensive retinopathy13.2ACE, ADIPOQ
16rheumatoid vasculitis13.2VCAM1, ICAM1
17idiopathic myopathy13.2VCAM1, MCAM, ICAM1
18chronic pulmonary heart disease13.2EDN1, ADIPOQ
19arterial occlusive disease13.2SELP, VCAM1
20hemorrhagic fever with renal syndrome13.2VCAM1, ITGA4, ICAM1
21mitral valve disease13.2SELP, ACE
22membranoproliferative glomerulonephritis type 213.2VCAM1, ITGAL, ICAM1
23leukostasis13.1VCAM1, ICAM1
24atopic dermatitis13.1SELP, VCAM1, ICAM1, PF4
25adult-onset still's disease13.1ANXA5, ICAM1, HGF
26carotid intimal medial thickness13.1ICAM1, ACE, ADIPOQ
27serous glue ear13.1VCAM1, ITGAL, ICAM1
28neurocirculatory asthenia13.1SELP, PF4, ACE
29allergic conjunctivitis13.0ITGA4, ITGAL, ICAM1
30mastocytosis13.0CD2, CD63, PF4
31immune-complex glomerulonephritis13.0SELP, VCAM1, ITGAL, ICAM1
32colorectal adenoma and carcinoma13.0CD44, ADIPOQ, HGF
33fabry disease13.0VCAM1, ICAM1, ACE
34carotid stenosis13.0SELP, DUSP2, ACE
35allergic encephalomyelitis13.0ITGA4, ITGAL, ICAM1
36thromboangiitis obliterans13.0VCAM1, ICAM1, EDN1
37deep vein thrombosis13.0SELP, ACE, HGF
38cerebral artery occlusion12.9SELP, ICAM1, EDN1
39peripheral vascular disease12.9SELP, VCAM1, PF4, ACE
40wheat allergic reaction12.9VCAM1, ITGA4, ICAM1
41sleep disorder12.9VCAM1, ICAM1, ACE, ADIPOQ
42polycythemia vera12.9SELP, PF4, ACE, HGF
43allergic contact dermatitis of eyelid12.9SELP, VCAM1, ICAM1, ACE
44leukocyte-adhesion deficiency syndrome12.9SELP, ITGA4, ITGAL, ICAM1
45contact dermatitis12.8SELP, VCAM1, ICAM1, ACE
46lichen sclerosus12.8CD44, ITGAL, ICAM1
47hyperuricemia12.8SELP, MCAM, ACE
48crescentic glomerulonephritis12.8VCAM1, ITGA4, ITGAL, ICAM1
49takayasu's arteritis12.8SELP, VCAM1, ICAM1, EDN1
50plasmodium falciparum malaria12.8SELP, ICAM1, EDN1

Graphical network of the top 20 diseases related to arteriosclerosis obliterans:



Graphical network of diseases related to arteriosclerosis obliterans

Clinical Features for Arteriosclerosis Obliterans

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Drugs & Therapeutics for Arteriosclerosis Obliterans

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for arteriosclerosis obliterans

Drug clinical trials:

Search ClinicalTrials for arteriosclerosis obliterans

Search NIH Clinical Center for arteriosclerosis obliterans

Search CenterWatch for arteriosclerosis obliterans

Inferred drug relations via UMLS/NDF-RT:

43 28 tolazoline, tolazoline hydrochloride

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for arteriosclerosis obliterans:
Bone marrow derived CD133+ or monoucleated cells for treatment of peripheral artery disease

Genetic Tests for Arteriosclerosis Obliterans

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Anatomical Context for Arteriosclerosis Obliterans

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22MalaCards
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MalaCards organs/tissues related to arteriosclerosis obliterans:

22
Bone marrow, Heart, Smooth muscle, Endothelial

Phenotypes for genes affiliated with Arteriosclerosis Obliterans

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25MGI
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MGI Mouse Phenotypes related to arteriosclerosis obliterans:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1hematopoietic system phenotypeMP:00053979.5FGF2, PTGIR, HGF
2immune system phenotypeMP:00053879.1ADIPOQ, DUSP2, ITGAL, ITGA4, SELP
3mortality/agingMP:00107687.7ACE, EDN1, PTGIR, TPM1, ITGA4, VCAM1
4tumorigenesisMP:00020067.3ADIPOQ, ACE, PTGIR, ICAM1, FGF2, ITGAL
5cellular phenotypeMP:00053846.7ADIPOQ, ACE, ICAM1, FGF2, ITGAL, ITGA4
6cardiovascular system phenotypeMP:00053856.3HGF, ADIPOQ, ACE, EDN1, PTGIR, ICAM1
7homeostasis/metabolism phenotypeMP:00053766.0ADIPOQ, ACE, EDN1, PF4, PTGIR, ICAM1

Publications for genes affiliated with Arteriosclerosis Obliterans

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35PubMed
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Articles related to arteriosclerosis obliterans:

(show all 13)
idTitleAuthorsYearAffiliating Genes
1MicroRNA-21 regulates vascular smooth muscle cell fun ction via targeting tropomyosin 1 in arteriosclerosis obliterans of lower extre mities. (21817107)Wang M.... Wang S.M.2011TPM1, MIR21
2Tc-99m-MIBI scintigraphy in evaluating the effect of hepatocyte growth factor gene therapy for peripheral arteriosclerosis obliterans. (19225945)Yamagami T.... Nishimura T.2009HGF
3Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans. (18175063)Saito O.... Kusano E.2008ICAM1, VCAM1, ADIPOQ
4Effects of selective LDL apheresis on plasma concentrations of ICAM-1, VCAM-1 and P-selectin in diabetic patients with arteriosclerosis obliterans and receiving maintenance hemodialysis. (17126824)Utsumi K.... Katayama Y.2007ICAM1, SELP, VCAM1
5Angiotensin I-converting enzyme inhibitor improves reactive hyperemia in elderly hypertensives with arteriosclerosis obliterans. (17249520)Okuro M.... Matsumoto M.2006ACE
6Close association of hypoadiponectinemia with arteriosclerosis obliterans and ischemic heart disease. (15877296)Kawano T.... Ishikawa S.E.2005ADIPOQ
7Three cases of ischemic ulcer due to arteriosclerosis obliterans responding to basic fibroblast growth factor spray. (15372302)Noguchi M.... Hazama S.2004FGF2
8Platelet activation markers, microparticles and soluble adhesion molecules are elevated in patients with arteriosclerosis obliterans: therapeutic effects by cilostazol and potentiation by dipyridamole. (15203718)Nomura S.... Liu Y.2004SELP, ANXA5, CD63
9Effect of low-density lipoprotein apheresis on plasma endothelin-1 levels in diabetic hemodialysis patients with arteriosclerosis obliterans. (14583180)Nakamura T.... Koide H.2003EDN1
10A novel serotonin blocker, sarpogrelate, increases circulating adiponectin levels in diabetic patients with arteriosclerosis obliterans. (12882890)Yamakawa J.... Kanda T.2003ADIPOQ
11Effects of sarpogrelate hydrochloride on adenosine diphosphate- or collagen-induced platelet responses in arteriosclerosis obliterans. (11505083)Nakamura K.... Yamada K.2001SELP
12Blood coagulation disorders observed in arteriosclerosis obliterans (8808808)Ishimaru S.1996PF4
13Removal of LDL from plasma by adsorption reduces adhesion molecules on mononuclear cells in patients with arteriosclerosis obliterans. (7488336)Uno H.... Yano K.1995ITGA4, CD44, ITGAL

Expression for genes affiliated with Arteriosclerosis Obliterans

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Arteriosclerosis Obliterans

Pathways for genes affiliated with Arteriosclerosis Obliterans

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20KEGG, 36QIAGEN, 41Thomson Reuters, 10EMD Millipore, 38Reactome, 3Cell Signaling Technology
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Pathways related to arteriosclerosis obliterans according to GeneDecks:

(show all 22)
idPathwayScoreTop Affiliating Genes
1Staphylococcus aureus infection209.8ICAM1, ITGAL, SELP
2Akt Signaling369.7CD2, ITGAL, PF4, HGF
3Malaria209.6SELP, VCAM1, ITGAL, ICAM1, HGF
4Immune response_Role of integrins in NK cells cytotoxicity419.6ICAM1, ITGAL, ITGA4, VCAM1
5Immune response Role of integrins in NK cells cytotoxicity109.6ICAM1, ITGAL, ITGA4, VCAM1
6Actin-Based Motility by Rho Family GTPases369.6ITGA4, ITGAL
7Leukocyte transendothelial migration209.5ICAM1, ITGAL, ITGA4, VCAM1
8Cell adhesion molecules (CAMs)209.5ITGAL, ITGA4, CD2, SELP
9Regulation of eIF4 and p70S6K369.5CD2, ITGA4, ITGAL
10Cell surface interactions at the vascular wall389.5SELP, CD2, ITGA4, ITGAL
11ERK Signaling369.4CD2, ITGA4, ITGAL, PF4
12Endothelin-1 Signaling Pathway369.3HGF, EDN1, PF4, CD2
13Transendothelial Migration of Leukocytes369.3VCAM1, ITGA4, ITGAL, ICAM1, PF4
14PPAR Pathway369.1PTGIR, FGF2, ITGAL, ITGA4
15Adhesion39.0ICAM1, ITGA4, CD44
16Renin-Angiotensin Pathway368.9HGF, ACE, PTGIR, FGF2, VCAM1
17Tec Kinases Signaling368.8HGF, FGF2, ITGAL, ITGA4, CD2
18Rho Family GTPases368.6HGF, PF4, FGF2, ITGAL, ITGA4, CD2
19Paxillin Interactions368.6FGF2, ITGAL, ITGA4, HGF
20Molecular Mechanisms of Cancer368.5HGF, PF4, FGF2, ITGAL, ITGA4, CD2
21Glioma Invasiveness368.4HGF, FGF2, ITGAL, ITGA4, CD44
22Rac1 Pathway368.3HGF, FGF2, ITGAL, ITGA4, CD44

Compounds for genes affiliated with Arteriosclerosis Obliterans

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32Novoseek , 34PharmGKB, 9DrugBank, 18HMDB, 42Tocris Bioscience
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Compounds related to arteriosclerosis obliterans according to GeneDecks:

(show top 50)    (show all 146)
idCompoundScoreTop Affiliating Genes
1tetramethylpyrazine32 10.7SELP
2sele32 10.1ACE, SELP
3pravastatin32 34 9 18 9 13.8SELP, ITGAL, ADIPOQ
4cilostazol32 42 9 9 12.7HGF, VCAM1, SELP, PF4
5cuprophan32 9.7ICAM1, ITGAL, VCAM1, SELP, PF4
6slea32 9.7SELP, ICAM1, ITGAL, ITGA4
7mdmp32 9.7DUSP2, ANXA5, CD63, SELP
8dermatan sulfate32 9.6SELP, FGF2, PF4, HGF
9pdmp32 9.5ICAM1, ANXA5, CD63, SELP, DUSP2
10iloprost32 42 9 9 12.4EDN1, PF4, SELP, PTGIR, VCAM1
11fluvastatin32 34 9 9 12.4VCAM1, ICAM1, ANXA5, ITGAL, SELP
12heparin32 9 18 9 12.2HGF, ADIPOQ, ANXA5, ITGA4, ITGAL
13valsartan32 42 9 9 12.2EDN1, SELP, ACE, ADIPOQ
14N,O6-Disulfo-Glucosamine9 9 10.2HGF, FGF2, ANXA5
15dextran sulfate32 9.2ICAM1, HGF, CD44, SELP, PF4
16vegf32 9.1ICAM1, PF4, HGF, FGF2, VCAM1, SELP
17simvastatin32 34 42 9 18 9 14.1ICAM1, ADIPOQ, ANXA5, ITGAL, VCAM1, SELP
18fmlp32 9.1SELP, ICAM1, VCAM1, PF4, ITGAL, ITGA4
19thromboxane a232 18 10.1CD63, SELP, PTGIR, PF4, EDN1
20losartan32 34 9 9 12.0VCAM1, SELP, ACE, ADIPOQ, HGF, EDN1
21hyaluronic acid32 18 9.9FGF2, ITGAL, CD44
22lacidipine32 8.9EDN1, ACE, VCAM1
23enalapril32 9 9 10.9EDN1, ACE, ADIPOQ, HGF
24slex32 8.7VCAM1, ITGAL, ITGA4, CD44, SELP, ICAM1
25pge232 8.7EDN1, PF4, VCAM1, ADIPOQ, FGF2, HGF
26norepinephrine32 9 18 9 11.6ACE, HGF, SELP, VCAM1, PF4, EDN1
27aspirin32 34 18 10.6HGF, ADIPOQ, ACE, PF4, ITGAL, CD63
28ly29400232 8.5ICAM1, FGF2, ANXA5, CD44, ADIPOQ
29sb 20358032 42 9.4VCAM1, ICAM1, FGF2, HGF, ADIPOQ, ANXA5
30polysaccharide32 8.3FGF2, VCAM1, PF4, CD44, HGF, ICAM1
31adenylate32 8.3HGF, VCAM1, DUSP2, ADIPOQ, PF4, PTGIR
32wortmannin32 42 9.2ANXA5, PF4, ADIPOQ, HGF, ITGAL, CD63
33carbohydrates32 8.2FGF2, CD44, ANXA5, ADIPOQ, VCAM1, SELP
34cytochalasin d32 42 9.2FGF2, ITGA4, CD44, VCAM1, ITGAL, ICAM1
35fibrinogen32 8.1ADIPOQ, PF4, DUSP2, ICAM1, ANXA5, ITGAL
36lactate32 8.0ICAM1, SELP, PF4, ADIPOQ, HGF, VCAM1
37genistein32 9 18 9 11.0EDN1, ICAM1, SELP, VCAM1, ITGA4, FGF2
38prostacyclin32 7.7ACE, ADIPOQ, EDN1, PF4, PTGIR, ICAM1
39rantes32 7.7CD63, CD44, ITGA4, ADIPOQ, PF4, DUSP2
40cholesterol32 9 18 9 10.6PF4, ITGAL, CD44, ACE, ADIPOQ, SELP
41actinomycin d32 7.4EDN1, ITGAL, HGF, ADIPOQ, ICAM1, ANXA5
42cyclosporin a32 42 8.2HGF, EDN1, FGF2, CD44, ANXA5, ITGAL
43dexamethasone32 42 34 9 9 11.1ITGAL, ITGA4, ANXA5, ICAM1, ADIPOQ, SELP
44retinoic acid32 42 18 9.1ITGA4, CD44, SELP, VCAM1, ITGAL, FGF2
45cycloheximide32 7.1EDN1, ICAM1, ANXA5, FGF2, ITGAL, ITGA4
46nitric oxide32 9 18 9 10.0SELP, VCAM1, CD63, CD44, ITGA4, ITGAL
47lipid32 6.9VCAM1, CD2, CD63, CD44, ADIPOQ, HGF
48tyrosine32 6.1ITGA4, ITGAL, DUSP2, ICAM1, ANXA5, MCAM
49phosphatidylinositol32 6.0FGF2, CD63, VCAM1, ITGA4, ITGAL, ANXA5
50calcium32 9 18 9 8.6ITGA4, TPM1, MCAM, ANXA5, CD44, DUSP2

GO Terms for genes affiliated with Arteriosclerosis Obliterans

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12Gene Ontology
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Cellular components related to arteriosclerosis obliterans according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet dense granule membraneGO:0310889.6CD63, SELP
2extracellular spaceGO:0056157.5HGF, ADIPOQ, ACE, EDN1, PF4, ICAM1
3external side of plasma membraneGO:0098976.7SELP, ACE, ICAM1, ANXA5, MCAM, ITGAL
4plasma membraneGO:0058866.6PTGIR, ICAM1, MCAM, ITGAL, ITGA4, CD44

Biological processes related to arteriosclerosis obliterans according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.3ICAM1, VCAM1
2T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.2ICAM1, ITGAL
3negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.1PTGIR, ADIPOQ
4chorio-allantoic fusionGO:06071010.1ITGA4, VCAM1
5platelet degranulationGO:0025769.8HGF, PF4, CD63, SELP
6positive regulation of cell adhesionGO:0457859.8SELP, CD63, TPM1
7leukocyte tethering or rollingGO:0509019.7SELP, VCAM1
8negative regulation of hormone secretionGO:0468889.7EDN1, ADIPOQ
9platelet activationGO:0301689.6HGF, PF4, CD63, SELP
10regulation of immune responseGO:0507769.5VCAM1, ITGA4, ITGAL, ICAM1
11leukocyte cell-cell adhesionGO:0071599.4SELP, VCAM1, ITGA4, ITGAL, ICAM1
12positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.4CD44, ADIPOQ, HGF
13heterophilic cell-cell adhesionGO:0071579.4ICAM1, ITGAL, ITGA4, VCAM1, SELP
14cell adhesionGO:0071559.3ICAM1, MCAM, ITGAL, VCAM1, SELP
15leukocyte migrationGO:0509009.3ICAM1, ITGAL, ITGA4, CD2, SELP
16interferon-gamma-mediated signaling pathwayGO:0603339.2ICAM1, CD44, VCAM1
17cytokine-mediated signaling pathwayGO:0192219.0PF4, ICAM1, CD44, VCAM1
18blood coagulationGO:0075968.0HGF, PF4, PTGIR, ANXA5, ITGAL, ITGA4

Molecular functions related to arteriosclerosis obliterans according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:03369110.0SELP, ADIPOQ
2eukaryotic cell surface bindingGO:0434999.0SELP, CD2, ANXA5, ADIPOQ

Sources for Arteriosclerosis Obliterans

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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