MCID: ART008
MIFTS: 53

Arteriosclerosis Obliterans malady

Summaries for Arteriosclerosis Obliterans

About this section
Sources:
63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:63 Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal... more...

MalaCards: Arteriosclerosis Obliterans is related to arteriosclerosis and hypertension. An important gene associated with Arteriosclerosis Obliterans is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Thromboxane A2 receptor signaling and Malaria. The drugs tolazoline and tolazoline hydrochloride and the compounds cycloheximide and losartan have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and bone, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Arteriosclerosis Obliterans

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH
See all sources

Aliases & Descriptions:

arteriosclerosis obliterans 8 10 44 60


External Ids:

Disease Ontology8 DOID:5160
SNOMED-CT56 60625000, 361133006
MeSH34 D001162

Related Diseases for Arteriosclerosis Obliterans

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Arteriosclerosis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.9HGF, VCAM1, EDN1, ICAM1, ADIPOQ
2hypertension30.8ICAM1, VCAM1, PTGIR, ACE, EDN1
3diabetes mellitus30.7ADIPOQ, EDN1, SELP, ACE, PF4, VCAM1
4ischemia30.5FGF2, SELP, PF4, EDN1, ITGAL, ICAM1
5intermittent claudication30.4FGF2, PF4, SELP
6ischemic heart disease30.3PF4, EDN1, ACE, SELP
7myocardial infarction30.3ITGAL, ANXA5, CD2, PF4, ACE, SELP
8atherosclerosis30.3SELP, VCAM1, ACE, FGF2, PF4, ADIPOQ
9lupus erythematosus30.1ANXA5
10blood platelet disease30.1PF4, SELP
11peripheral vascular disease30.1SELP, VCAM1
12systemic lupus erythematosus30.1VCAM1, CD2, ANXA5, ITGA4, ICAM1, ITGAL
13essential hypertension30.1SELP, ADIPOQ, ACE, PF4, CD2, EDN1
14coronary artery disease30.1ACE, ICAM1, ADIPOQ, VCAM1, SELP, PF4
15type 2 diabetes mellitus30.1VCAM1, CD63, DUSP2, EDN1, ACE, ADIPOQ
16vascular disease30.1VCAM1, ACE, ADIPOQ, ICAM1, SELP, FGF2
17thromboangiitis obliterans10.5
18aortic aneurysm10.4
19coronary arteriosclerosis10.3
20cerebritis10.3
21aneurysm disease10.3
22aortic disease10.3
23wrinkles10.1
24coronary aneurysm10.1
25abdominal aortic aneurysm10.1
26heart aneurysm10.1
27purpura10.1
28ruptured aortic aneurysm10.1
29thrombophlebitis10.1
30venous insufficiency10.1
31peritonitis10.0SELP
32obesity10.0ADIPOQ
33hepatitis10.0HGF
34galactosemia10.0ICAM1
35biliary atresia10.0HGF
36myopathy10.0TPM1
37myeloid leukemia10.0ITGAL
38hypertrophic cardiomyopathy10.0TPM1
39proliferative glomerulonephritis10.0SELP
40polycystic ovary syndrome10.0ADIPOQ
41respiratory failure10.0ICAM1
42migraine10.0ITGAL
43severe pre-eclampsia10.0VCAM1
44hepatitis c10.0ANXA5
45sarcoma10.0ITGA4
46crohn's disease10.0ITGA4
47carotid stenosis10.0SELP
48thromboembolism10.0SELP, PF4
49acute leukemia10.0ITGA4
50coronary stenosis10.0SELP, ADIPOQ

Graphical network of the top 20 diseases related to Arteriosclerosis Obliterans:



Diseases related to arteriosclerosis obliterans

Clinical Features for Arteriosclerosis Obliterans

About this section

Drugs & Therapeutics for Arteriosclerosis Obliterans

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arteriosclerosis Obliterans

Drug clinical trials:

Search ClinicalTrials for Arteriosclerosis Obliterans

Search NIH Clinical Center for Arteriosclerosis Obliterans

Search CenterWatch for Arteriosclerosis Obliterans

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Arteriosclerosis Obliterans

About this section

Anatomical Context for Arteriosclerosis Obliterans

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Arteriosclerosis Obliterans:

32
Heart, Skin, Bone, Bone marrow, Spleen, Endothelial, Smooth muscle

Animal Models for Arteriosclerosis Obliterans or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Arteriosclerosis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.5ICAM1, ITGAL, PTGIR
2MP:00053848.0ICAM1, ITGA4, ITGAL, CD44, FGF2, ACE
3MP:00053977.6CD44, ITGAL, ITGA4, ICAM1, HGF, PF4
4MP:00053857.5TPM1, HGF, ICAM1, EDN1, ITGA4, CD44
5MP:00107687.5HGF, ICAM1, EDN1, ITGA4, CD44, FGF2
6MP:00053877.3DUSP2, ANXA5, ITGAL, ITGA4, ICAM1, CD44
7MP:00053766.7CD63, CD44, ITGAL, EDN1, ICAM1, PF4

Publications for Arteriosclerosis Obliterans

About this section
Sources:
50PubMed
See all sources

Articles related to Arteriosclerosis Obliterans:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients. (23749750)
2013
2
Study design of SEASON registry: prospective Surveillance of cardiovascular Events in an Antiplatelet-treated arterioSclerosis Obliterans patients in JapaN )SEASON). (20966606)
2010
3
Current status of the medical expenses for the treatment of arteriosclerosis obliterans in Japan. (20357751)
2010
4
Changes in the activities of daily living (ADL) in relation to the level of amputation of patients undergoing lower extremity amputation for arteriosclerosis obliterans (ASO). (18724029)
2008
5
Detecting vulnerable plaque of arteriosclerosis obliterans by multidetector-row computed tomography--comparing with VH (virtual histology)-intravascular ultrasound. (17512620)
2008
6
Effects of selective LDL apheresis on plasma concentrations of ICAM-1, VCAM-1 and P-selectin in diabetic patients with arteriosclerosis obliterans and receiving maintenance hemodialysis. (17126824)
2007
7
Efficacy of low-density lipoprotein apheresis in arteriosclerosis obliterans of the lower extremities: two cases with marked alleviation of clinical symptoms. (17610290)
2007
8
Effect of the serotonin blocker sarpogrelate on circulating interleukin-18 levels in patients with diabetes and arteriosclerosis obliterans. (15080020)
2004
9
A case of arteriosclerosis obliterans with monitored regional oxygen saturation during treatment with a lumbar sympathetic ganglion block. (14556145)
2003
10
Platelet scintigraphy in the diagnosis of arteriosclerosis obliterans. (12376783)
2002
11
Effects of sarpogrelate hydrochloride on adenosine diphosphate- or collagen-induced platelet responses in arteriosclerosis obliterans. (11505083)
2001
12
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. (9698948)
1998
13
Dipyridamole thallium-201 single-photon emission computed tomography for prediction of perioperative cardiac events in patients with arteriosclerosis obliterans undergoing vascular surgery. (9583461)
1998
14
Heparin and exercise treatment in a patient with arteriosclerosis obliterans. (9276778)
1997
15
Enhancement of nitric oxide production after arterial reconstruction in patients with arteriosclerosis obliterans. (9357468)
1997
16
Removal of LDL from plasma by adsorption reduces adhesion molecules on mononuclear cells in patients with arteriosclerosis obliterans. (7488336)
1995
17
Observation of atherosclerotic lesions by an intravascular microscope in patients with arteriosclerosis obliterans. (7484744)
1995
18
Dipyridamole thallium-201 scintigraphy in patients with arteriosclerosis obliterans. Increased accuracy in identifying cardiac risk. (1296184)
1992-1993
19
Lipid and lipoprotein abnormalities in lower-extremity arteriosclerosis obliterans. (1468132)
1992
20
Therapeutic effects of nitrendipine (Bayotensin) in patients with arteriosclerosis obliterans of lower limbs. (2678132)
1989
21
Some haemorheological factors in patients with arteriosclerosis obliterans after treatment of trental. (2446996)
1987
22
Regional compliance of brachial artery and saline infusion in patients with arteriosclerosis obliterans. (3966910)
1985
23
Thromboxane B2, 6-keto-PGF1 alpha, PGE2, PGF2 alpha, and PGA1 plasma levels in arteriosclerosis obliterans: relationship to clinical manifestations, risk factors, and arterial pathoanatomy. (6581715)
1984
24
Clinical experience with prostaglandin E1 in the treatment of arteriosclerosis obliterans. A preliminary report. (6577118)
1983
25
Prevalence of severe arteriosclerosis obliterans in patients with diabetes mellitus. Relation to smoking and form of therapy. (7052035)
1982
26
Systemic arterial compliance in patients with arteriosclerosis obliterans of the lower limbs. Observations on the effect of intravenous propranolol. (7092715)
1982
27
Lumbar sympathectomy in arteriosclerosis obliterans: a clinical and ultrasound study. (604464)
1977
28
Applications of ultrasound to the study of arteriosclerosis obliterans. (1090218)
1975
29
Arteriosclerosis obliterans of the lower extremities in non-diabetic men: survival and causes of death. (1139967)
1975
30
Problems of aging: diagnosing and treating leg pain due to arteriosclerosis obliterans. (1099566)
1975
31
Blood zinc levels in patients with arteriosclerosis obliterans, thromboangiitis obliterans and Takayasu's disease. (241871)
1975
32
Endarteritis obliterans or arteriosclerosis obliterans. (1228578)
1975
33
Vital capillary microscopy. A clinical method for studying changes of the nutritional skin capillaries in legs with arteriosclerosis obliterans. (4767567)
1973
34
ABO blood type and arteriosclerosis obliterans. (5012694)
1972
35
Auto-amputation in arteriosclerosis obliterans. (5022706)
1972
36
Peripheral hemodynamics in patients with coarctation, normotensive and hypertensive arteriosclerosis obliterans of the lower limbs. (5091548)
1971
37
Mofette therapy and CO2 waterbaths for arteriosclerosis obliterans. (5432000)
1970
38
Pulse morphological plethysmography of the forefoot in arteriosclerosis obliterans. (6056910)
1967
39
Arteriographic changes in femoropopliteal arteriosclerosis obliterans. A five-year follow-up study. (17926375)
1966
40
The significance of an autograft of the great saphenous vein in the treatment of arteriosclerosis obliterans of the thigh. (13803883)
1960
41
Muscle blood flow in patients with arteriosclerosis obliterans. (13559561)
1958
42
Observations in the management of late arteriosclerosis obliterans with gangrene. (13435661)
1957
43
Arteriosclerosis obliterans. I. Plethysmographic studies of peripheral circulation following administration of vasodilators. (14350291)
1955
44
Use of vasodilator drugs in the treatment of diabetic arteriosclerosis obliterans. (13162729)
1954
45
CLINICAL pathologic conference: diabetes mellitus with complications, including generalized arteriosclerosis, cerebral arteriosclerosis, coronary arteriosclerosis, hypertensive cardiovascular disease and arteriosclerosis obliterans of the extremities. (13011459)
1952
46
Some limitations of lumbar sympathectomy in arteriosclerosis obliterans; early results in one hundred consecutive cases. (14877405)
1952
47
Endarteriectomy, or surgical restoration of the lumen of an obstructed artery in arteriosclerosis obliterans; a preliminary report. (14926051)
1952
48
Lumbar sympathectomy in the treatment of peripheral arteriosclerosis obliterans. (14940915)
1952
49
Tetraethyl ammonium chloride in the treatment of arteriosclerosis obliterans; preliminary report. (18145997)
1949
50
Arteriosclerosis obliterans of the abdominal aorta. (20999992)
1946

Genetic Variations for Arteriosclerosis Obliterans

About this section

Expression for genes affiliated with Arteriosclerosis Obliterans

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arteriosclerosis Obliterans

Search GEO for disease gene expression data for Arteriosclerosis Obliterans.

Pathways for genes affiliated with Arteriosclerosis Obliterans

About this section
Sources:
37NCBI BioSystems Database, 29KEGG, 53Reactome, 4Cell Signaling Technology, 12EMD Millipore, 51QIAGEN
See all sources

Pathways related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PTGIR
210.0ITGAL
39.8CD2, CD44, ITGA4
49.7EDN1, ANXA5, PTGIR
5
Hide members
9.7HGF, ICAM1, CD44, VCAM1
69.6ICAM1, ITGA4, CD44, VCAM1
79.6ICAM1, ITGAL, SELP
89.4VCAM1, ITGAL, ITGA4, ICAM1
99.4VCAM1, ITGAL, ITGA4, ICAM1
109.4ITGA4, ITGAL, CD2, SELP
11
Hide members
9.4HGF, FGF2, ACE, PTGIR, VCAM1
12
Hide members
9.3SELP, PF4, CD63, HGF
13
Hide members
9.3ITGA4, ITGAL, CD44, VCAM1
14
Hide members
9.1FGF2, CD2, ITGAL, ITGA4, HGF
15
Hide members
9.0ICAM1, ITGA4, ITGAL, PF4, VCAM1
169.0ICAM1, ITGA4, ITGAL, CD2, VCAM1, SELP
178.9HGF, MIR21, CD44, CD63, FGF2
18
Hide members
8.8ICAM1, ITGA4, ITGAL, CD44, FGF2, VCAM1
19
Hide members
8.8HGF, ICAM1, ITGA4, ITGAL, CD44, FGF2
20
Hide members
8.8HGF, ITGA4, ITGAL, CD44, FGF2, PTGIR
21
Hide members
8.8HGF, ITGA4, ITGAL, CD2, PF4, FGF2
22
Hide members
8.6HGF, ITGA4, ITGAL, CD2, CD63, PF4
23
Hide members
8.3ICAM1, EDN1, ITGA4, ITGAL, PF4, FGF2

Compounds for genes affiliated with Arteriosclerosis Obliterans

About this section
Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 59Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1cycloheximide4410.5HGF
2losartan44 49 28 1113.2SELP, HGF, EDN1
3sele4410.0SELP, ACE, ICAM1, VCAM1
4pge2449.8PF4, CD44, ITGAL
5cilostazol44 1110.8HGF, PF4, VCAM1, SELP
6dermatan sulfate449.8FGF2, PF4, CD44, SELP
7valsartan44 59 28 1112.8EDN1, ACE, SELP, ADIPOQ
8slea449.7ITGA4, ICAM1, ITGAL, SELP
9tetramethylpyrazine449.7ICAM1, EDN1, ITGAL, SELP
10iloprost44 59 28 1112.7PTGIR, VCAM1, SELP, PF4, EDN1
11N,O6-Disulfo-Glucosamine119.7HGF, FGF2, ANXA5
12mdmp449.7ANXA5, DUSP2, CD63, SELP
13dextran sulfate449.7CD44, PF4, ICAM1, SELP, HGF
14pdmp449.5ICAM1, DUSP2, ANXA5, CD63, SELP
15cuprophan449.5ICAM1, PF4, VCAM1, ITGAL, SELP
16carbohydrates449.5ANXA5, CD44, FGF2, VCAM1, ADIPOQ, SELP
17fluvastatin44 49 28 1112.4ANXA5, SELP, VCAM1, ITGAL, ICAM1
18rantes449.4ICAM1, ITGA4, CD44, PF4, ITGAL
19slex449.4ITGA4, ICAM1, ITGAL, SELP, CD44, VCAM1
20pravastatin44 49 28 11 2413.4ADIPOQ, SELP, VCAM1, ITGAL, ICAM1
21sb 20358044 5910.3ANXA5, ICAM1, HGF, ADIPOQ, FGF2, EDN1
22simvastatin44 49 59 28 11 2414.3ADIPOQ, VCAM1, SELP, ANXA5, ICAM1, ITGAL
23dexamethasone44 49 28 1112.3FGF2, ANXA5, ITGAL, ITGA4, ADIPOQ, HGF
24polysaccharide449.2ICAM1, VCAM1, FGF2, SELP, PF4, CD44
25enalapril44 49 1111.2HGF, EDN1, ADIPOQ, ACE
26ly294002449.2ADIPOQ, CD44, SELP, VCAM1, FGF2, ANXA5
27thromboxane a244 2410.2CD63, SELP, PTGIR, PF4, EDN1
28cytochalasin d44 5910.2FGF2, ICAM1, ITGA4, ITGAL, VCAM1, CD44
29hyaluronic acid44 2410.2HGF, ICAM1, CD44, ITGAL, VCAM1, FGF2
30genistein44 28 59 2 11 2414.1ANXA5, FGF2, ITGA4, SELP, EDN1, ICAM1
31fmlp449.1ICAM1, ITGA4, ITGAL, PF4, VCAM1, SELP
32glucose449.0PF4, CD63, CD2, CD44, ITGA4
33adenylate448.9ADIPOQ, SELP, VCAM1, HGF, PTGIR, PF4
34heparin44 28 11 2411.8ADIPOQ, SELP, VCAM1, PF4, CD44, ANXA5
35actinomycin d448.7EDN1, ICAM1, FGF2, HGF, ADIPOQ, ITGAL
36lactate448.7ANXA5, ICAM1, SELP, HGF, PF4, CD44
37vegf448.7PF4, FGF2, ANXA5, SELP, CD44, VCAM1
38prostacyclin448.7ICAM1, EDN1, PF4, FGF2, ACE, PTGIR
39oxygen44 249.6ITGAL, ITGA4, ANXA5, CD44, PF4, ICAM1
40cyclosporin a44 28 5910.6SELP, FGF2, CD44, ANXA5, ITGAL, EDN1
41aspirin44 49 28 2411.4ADIPOQ, SELP, ACE, PF4, CD63, ITGAL
42retinoic acid44 249.4ADIPOQ, ITGA4, HGF, SELP, VCAM1, ICAM1
43wortmannin448.4ADIPOQ, VCAM1, PF4, ITGA4, HGF, ITGAL
44cholesterol44 28 11 2411.1SELP, ITGAL, PF4, CD63, ACE, VCAM1
45fibrinogen448.1SELP, CD63, DUSP2, PF4, ICAM1, VCAM1
46nitric oxide44 11 2410.1CD63, CD44, ITGAL, ITGA4, ICAM1, EDN1
47lipid447.8HGF, ACE, ADIPOQ, VCAM1, PTGIR, PF4
48phosphatidylinositol447.4DUSP2, HGF, ICAM1, ITGA4, ITGAL, EDN1
49tyrosine446.9MCAM, FGF2, HGF, ITGA4, ICAM1, ITGAL
50calcium44 49 11 249.7ITGA4, ITGAL, EDN1, PF4, ANXA5, TPM1

GO Terms for genes affiliated with Arteriosclerosis Obliterans

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet dense granule membraneGO:0310889.6CD63, SELP
2cell surfaceGO:0099869.2ITGA4, CD44, CD63, VCAM1, ADIPOQ
3extracellular regionGO:0055768.7EDN1, CD2, PF4, FGF2, ACE, ADIPOQ
4extracellular spaceGO:0056158.5HGF, ICAM1, EDN1, PF4, FGF2, ACE
5external side of plasma membraneGO:0098977.9SELP, ICAM1, ITGA4, ITGAL, ANXA5, CD44
6plasma membraneGO:0058867.2ICAM1, ITGA4, ITGAL, CD44, CD2, CD63

Biological processes related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.3VCAM1, ICAM1
2negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.3ADIPOQ, PTGIR
3chorio-allantoic fusionGO:06071010.2VCAM1, ITGA4
4T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.0ICAM1, ITGAL
5hyaluronan catabolic processGO:03021410.0FGF2, CD44
6negative regulation of hormone secretionGO:0468889.9ADIPOQ, EDN1
7interferon-gamma-mediated signaling pathwayGO:0603339.9VCAM1, CD44, ICAM1
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8HGF, CD44, ADIPOQ
9leukocyte tethering or rollingGO:0509019.8SELP, VCAM1
10cytokine-mediated signaling pathwayGO:0192219.6ICAM1, CD44, PF4, VCAM1
11platelet degranulationGO:0025769.6HGF, CD63, PF4, SELP
12regulation of immune responseGO:0507769.6VCAM1, ITGAL, ITGA4, ICAM1
13platelet activationGO:0301689.5HGF, CD63, PF4, SELP
14leukocyte cell-cell adhesionGO:0071599.5ICAM1, ITGA4, ITGAL, VCAM1, SELP
15heterophilic cell-cell adhesionGO:0071579.5ICAM1, ITGA4, ITGAL, VCAM1, SELP
16leukocyte migrationGO:0509009.5SELP, CD2, ITGAL, ITGA4, ICAM1
17cell adhesionGO:0071559.2ICAM1, ITGAL, MCAM, VCAM1, SELP
18blood coagulationGO:0075968.3SELP, HGF, ITGA4, ITGAL, ANXA5, CD2

Molecular functions related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:03369110.1ADIPOQ, SELP
2protein bindingGO:0055156.6ADIPOQ, HGF, ICAM1, EDN1, ITGA4, ITGAL

Products for genes affiliated with Arteriosclerosis Obliterans

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arteriosclerosis Obliterans

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet