MCID: ART008
MIFTS: 50

Arteriosclerosis Obliterans malady

Summaries for Arteriosclerosis Obliterans

Sources:
64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Wikipedia:64 Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal... more...

MalaCards: Arteriosclerosis Obliterans is related to arteriosclerosis and intermittent claudication. An important gene associated with Arteriosclerosis Obliterans is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Thromboxane A2 receptor signaling and Malaria. The drugs tolazoline and tolazoline hydrochloride and the compounds cycloheximide and losartan have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are tumorigenesis and cellular.

Aliases & Classifications for Arteriosclerosis Obliterans

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

arteriosclerosis obliterans 8 10 45 61


External Ids:

Disease Ontology8 DOID:5160
SNOMED-CT57 60625000, 361133006
MeSH35 D001162

Related Diseases for Arteriosclerosis Obliterans

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Arteriosclerosis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.9ADIPOQ, HGF, ICAM1, EDN1, VCAM1
2intermittent claudication30.4SELP, FGF2, PF4
3atherosclerosis30.4ADIPOQ, SELP, VCAM1, PTGIR, ACE, FGF2
4peripheral vascular disease30.2VCAM1, SELP
5blood platelet disease30.2PF4, SELP
6insulin resistance30.2EDN1, CD2, ACE, VCAM1, ADIPOQ
7systemic lupus erythematosus30.2ICAM1, ITGA4, ITGAL, ANXA5, CD2, VCAM1
8coronary artery disease,30.2ICAM1, EDN1, PF4, ACE, VCAM1, SELP
9coronary heart disease30.2EDN1, ITGAL, PF4, ACE, VCAM1, SELP
10vascular disease30.2ICAM1, EDN1, FGF2, ACE, VCAM1, SELP
11thromboangiitis obliterans10.5
12aortic aneurysm10.4
13aneurysm disease10.3
14aortic disease10.3
15cerebral arteriosclerosis10.3
16coronary aneurysm10.1
17abdominal aortic aneurysm10.1
18heart aneurysm10.1
19thrombophlebitis10.1
20venous insufficiency10.1
21coronary artery aneurysm10.1
22light chain deposition disease10.1
23chronic pain10.1
24lip disease10.1
25peritonitis10.0SELP
26obesity10.0ADIPOQ
27hepatitis10.0HGF
28galactosemia10.0ICAM1
29biliary atresia10.0HGF
30myopathy10.0TPM1
31myeloid leukemia10.0ITGAL
32hypertrophic cardiomyopathy10.0TPM1
33proliferative glomerulonephritis10.0SELP
34polycystic ovary syndrome10.0ADIPOQ
35respiratory failure10.0ICAM1
36migraine10.0ITGAL
37severe pre-eclampsia10.0VCAM1
38hepatitis c10.0ANXA5
39sarcoma10.0ITGA4
40lupus erythematosus10.0ANXA5
41crohn's disease10.0ITGA4
42carotid stenosis10.0SELP
43thromboembolism10.0SELP, PF4
44acute leukemia10.0ITGA4
45coronary stenosis10.0ADIPOQ, SELP
46myelodysplastic syndromes10.0ANXA5
47rhinitis10.0ICAM1, VCAM1
48hypertriglyceridemia10.0ADIPOQ, VCAM1
49severe combined immunodeficiency10.0ITGA4
50cholangiocarcinoma10.0HGF

Graphical network of the top 20 diseases related to Arteriosclerosis Obliterans:



Diseases related to arteriosclerosis obliterans

Clinical Features for Arteriosclerosis Obliterans

Drugs & Therapeutics for Arteriosclerosis Obliterans

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arteriosclerosis Obliterans

Drug clinical trials:

Search ClinicalTrials for Arteriosclerosis Obliterans

Search NIH Clinical Center for Arteriosclerosis Obliterans

Search CenterWatch for Arteriosclerosis Obliterans

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Arteriosclerosis Obliterans

Anatomical Context for Arteriosclerosis Obliterans

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Arteriosclerosis Obliterans:

33
Bone marrow, Whole blood, Spleen, Heart, Smooth muscle, Skin, Endothelial

Animal Models for Arteriosclerosis Obliterans or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Arteriosclerosis Obliterans

Sources:
51PubMed
See all sources

Articles related to Arteriosclerosis Obliterans:

(show top 50)    (show all 233)
idTitleAuthorsYear
1
Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients. (23749750)
2013
2
A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol. (23097651)
2012
3
Current status of the medical expenses for the treatment of arteriosclerosis obliterans in Japan. (20357751)
2010
4
Intractable wounds caused by arteriosclerosis obliterans with end-stage renal disease treated by aggressive debridement and epidermal grafting. (17637445)
2007
5
Serum levels of S-glutathionylated proteins as a risk-marker for arteriosclerosis obliterans. (17186986)
2007
6
Autoperipheral blood mononuclear cell transplantation improved giant ulcers due to chronic arteriosclerosis obliterans. (16865304)
2006
7
Low-density lipoprotein apheresis in a patient with arteriosclerosis obliterans and light chain deposition disease. (15224807)
2004
8
Prevalence of asymptomatic arteriosclerosis obliterans and its relationship with risk factors in inhabitants of rural communities in Japan: Tanno-Sobetsu study. (15488869)
2004
9
Clinical application of bone marrow implantation in patients with arteriosclerosis obliterans, and the association between efficacy and the number of implanted bone marrow cells. (15564705)
2004
10
Peripheral macrohemodynamics in patients with lower limb arteriosclerosis obliterans and type II diabetes mellitus. (12811388)
2003
11
Percutaneous transluminal angioplasty against arteriosclerosis obliterans in dialysis patients. (12579341)
2003
12
Effects of prostaglandin E1 infusion on limb hemodynamics and vasodilatory response in patients with arteriosclerosis obliterans. (9310272)
1997
13
The clinical features and treatment of arteriosclerosis obliterans with diabetes. (8674871)
1996
14
Improved skin blood flow and cutaneous temperature in the foot of a patient with arteriosclerosis obliterans by vasopressin V1 antagonist (OPC21268). A case report. (7486224)
1995
15
Arteriosclerosis obliterans. Diagnostic and nonoperative treatment options. (7479455)
1995
16
MRA imaging of arterial patency in undialyzed uremic patients with arteriosclerosis obliterans. (8771247)
1995
17
Screening of patients with ischemic heart disease by transesophageal atrial pacing and the selection of surgical therapy: in patients with arteriosclerosis obliterans and aortic aneurysm. (7721927)
1995
18
Perioperative changes in coagulative and fibrinolytic function during surgical treatment of abdominal aortic aneurysm and arteriosclerosis obliterans. (7737753)
1994
19
Coronary artery disease in patients with arteriosclerosis obliterans of the lower extremities or aortic aneurysm. (1477473)
1992
20
Therapeutic effects of nitrendipine (Bayotensin) in patients with arteriosclerosis obliterans of lower limbs. (2678132)
1989
21
Effects of ketanserin on blood pressure, peripheral circulation and haemocoagulative parameters in essential hypertensives with or without arteriosclerosis obliterans of the lower limbs. (2943685)
1986
22
Dipyridamole and aspirin in arteriosclerosis obliterans of the lower limbs. (3159212)
1985
23
Hemodynamic effect of cilostazol on increasing peripheral blood flow in arteriosclerosis obliterans. (4074434)
1985
24
Fibrinolytic activity and the effects of beta-pyridylcarbinol (Ronicol) in patients with arteriosclerosis obliterans. (6364447)
1983
25
Erythrocyte deformability in patients with arteriosclerosis obliterans of lower limbs. (6679687)
1983
26
Effect of prostacyclin on fibrinolytic activity in patients with arteriosclerosis obliterans. (7048622)
1982
27
Lack of effect of ischemia and dipyridamole on prostacyclin production in arteriosclerosis obliterans. (7041195)
1981
28
Podiatric manifestations of aortoiliac arteriosclerosis obliterans. (7240635)
1981
29
Survival after arterial reconstruction in arteriosclerosis obliterans of the lower limbs. Follow-up after 10-20 years. (654831)
1978
30
Double-blind crossoer clinical trial of pyridinolcarbamate in peripheral arterial disease (arteriosclerosis obliterans). (4570447)
1973
31
Paradoxical effect on peripheral blood flow after sympathetic blockades in patients with gangrene due to arteriosclerosis obliterans. (5122534)
1971
32
Lumbar sympathectomy for arteriosclerosis obliterans. (5419582)
1970
33
The natural course of peripheral arteriosclerosis obliterans evaluated by flow measurements. (5802451)
1969
34
Below-the-knee amputation for arteriosclerosis obliterans, with and without diabetes mellitus. (5782884)
1969
35
Arteriosclerosis obliterans. Manner and rate of progression. (5952180)
1966
36
LUMBAR SYMPATHECTOMY IN ARTERIOSCLEROSIS OBLITERANS. (14179033)
1964
37
THROMBOANGIITIS OBLITERANS AND ARTERIOSCLEROSIS OBLITERANS. CLINICAL AND PROGNOSTIC DIFFERENCES. (14065946)
1963
38
A COMPARISON OF THE NATURAL HISTORY OF ARTERIOSCLEROSIS OBLITERANS WITH THE RESULTS OF ARTERIAL RECONSTRUCTION. (14053194)
1963
39
The management of the patient with arteriosclerosis obliterans. (13736768)
1961
40
Management of arteriosclerosis obliterans of the extremities. (13654008)
1959
41
Muscle blood flow in patients with arteriosclerosis obliterans. (13559561)
1958
42
Arteriosclerosis obliterans. (13596335)
1958
43
Technique of serial long film angiography in arteriosclerosis obliterans. (13362691)
1956
44
Follow-up studies of iliofemoral arterial reconstruction in arteriosclerosis obliterans. (13280042)
1956
45
Treatment of arteriosclerosis obliterans of the legs with continuous intra-arterial medication; discussion]. (14389460)
1955
46
Use of vasodilator drugs in the treatment of diabetic arteriosclerosis obliterans. (13162729)
1954
47
The restoration of main vessel patency in arteriosclerosis obliterans. (13150271)
1954
48
Arteriosclerosis obliterans of the lower extremities; its segmental nature and surgical implications. (13143253)
1954
49
Arteriosclerosis obliterans. (14807851)
1951
50
Sympathectomy for arteriosclerosis obliterans; rationale and results. (18934297)
1948

Genetic Variations for Arteriosclerosis Obliterans

Expression for genes affiliated with Arteriosclerosis Obliterans

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arteriosclerosis Obliterans

Search GEO for disease gene expression data for Arteriosclerosis Obliterans.

Pathways for genes affiliated with Arteriosclerosis Obliterans

Sources:
38NCBI BioSystems Database, 30KEGG, 54Reactome, 4Cell Signaling Technology, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 23)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3PTGIR
210.0ITGAL
39.8CD2, CD44, ITGA4
49.7EDN1, ANXA5, PTGIR
5
Hide members
9.7HGF, ICAM1, CD44, VCAM1
69.6ICAM1, ITGA4, CD44, VCAM1
79.6ICAM1, ITGAL, SELP
89.4VCAM1, ITGAL, ITGA4, ICAM1
99.4VCAM1, ITGAL, ITGA4, ICAM1
109.4ITGA4, ITGAL, CD2, SELP
11
Hide members
9.4HGF, FGF2, ACE, PTGIR, VCAM1
12
Hide members
9.3SELP, PF4, CD63, HGF
13
Hide members
9.3ITGA4, ITGAL, CD44, VCAM1
14
Hide members
9.1FGF2, CD2, ITGAL, ITGA4, HGF
15
Hide members
9.0ICAM1, ITGA4, ITGAL, PF4, VCAM1
169.0ICAM1, ITGA4, ITGAL, CD2, VCAM1, SELP
178.9HGF, MIR21, CD44, CD63, FGF2
18
Hide members
8.8ICAM1, ITGA4, ITGAL, CD44, FGF2, VCAM1
19
Hide members
8.8HGF, ICAM1, ITGA4, ITGAL, CD44, FGF2
20
Hide members
8.8HGF, ITGA4, ITGAL, CD44, FGF2, PTGIR
21
Hide members
8.8HGF, ITGA4, ITGAL, CD2, PF4, FGF2
22
Hide members
8.6HGF, ITGA4, ITGAL, CD2, CD63, PF4
23
Hide members
8.3ICAM1, EDN1, ITGA4, ITGAL, PF4, FGF2

Compounds for genes affiliated with Arteriosclerosis Obliterans

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 60Tocris Bioscience, 24HMDB, 2BitterDB
See all sources

Compounds related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 168)
idCompoundScoreTop Affiliating Genes
1cycloheximide4510.5HGF
2losartan45 50 29 1113.2SELP, HGF, EDN1
3sele4510.0SELP, ACE, ICAM1, VCAM1
4pge2459.8PF4, CD44, ITGAL
5cilostazol45 1110.8HGF, PF4, VCAM1, SELP
6dermatan sulfate459.8FGF2, PF4, CD44, SELP
7valsartan45 60 29 1112.8EDN1, ACE, SELP, ADIPOQ
8slea459.7ITGA4, ICAM1, ITGAL, SELP
9tetramethylpyrazine459.7ICAM1, EDN1, ITGAL, SELP
10iloprost45 60 29 1112.7PTGIR, VCAM1, SELP, PF4, EDN1
11N,O6-Disulfo-Glucosamine119.7HGF, FGF2, ANXA5
12mdmp459.7ANXA5, DUSP2, CD63, SELP
13dextran sulfate459.7CD44, PF4, ICAM1, SELP, HGF
14pdmp459.5ICAM1, DUSP2, ANXA5, CD63, SELP
15cuprophan459.5ICAM1, PF4, VCAM1, ITGAL, SELP
16carbohydrates459.5ANXA5, CD44, FGF2, VCAM1, ADIPOQ, SELP
17fluvastatin45 50 29 1112.4ANXA5, SELP, VCAM1, ITGAL, ICAM1
18rantes459.4ICAM1, ITGA4, CD44, PF4, ITGAL
19slex459.4ITGA4, ICAM1, ITGAL, SELP, CD44, VCAM1
20pravastatin45 50 29 11 2413.4ADIPOQ, SELP, VCAM1, ITGAL, ICAM1
21sb 20358045 6010.3ANXA5, ICAM1, HGF, ADIPOQ, FGF2, EDN1
22simvastatin45 50 60 29 11 2414.3ADIPOQ, VCAM1, SELP, ANXA5, ICAM1, ITGAL
23dexamethasone45 50 29 1112.3FGF2, ANXA5, ITGAL, ITGA4, ADIPOQ, HGF
24polysaccharide459.2ICAM1, VCAM1, FGF2, SELP, PF4, CD44
25enalapril45 50 1111.2HGF, EDN1, ADIPOQ, ACE
26ly294002459.2ADIPOQ, CD44, SELP, VCAM1, FGF2, ANXA5
27thromboxane a245 2410.2CD63, SELP, PTGIR, PF4, EDN1
28cytochalasin d45 6010.2FGF2, ICAM1, ITGA4, ITGAL, VCAM1, CD44
29hyaluronic acid45 2410.2HGF, ICAM1, CD44, ITGAL, VCAM1, FGF2
30genistein45 29 60 2 11 2414.1ANXA5, FGF2, ITGA4, SELP, EDN1, ICAM1
31fmlp459.1ICAM1, ITGA4, ITGAL, PF4, VCAM1, SELP
32glucose459.0PF4, CD63, CD2, CD44, ITGA4
33adenylate458.9ADIPOQ, SELP, VCAM1, HGF, PTGIR, PF4
34heparin45 29 11 2411.8ADIPOQ, SELP, VCAM1, PF4, CD44, ANXA5
35actinomycin d458.7EDN1, ICAM1, FGF2, HGF, ADIPOQ, ITGAL
36lactate458.7ANXA5, ICAM1, SELP, HGF, PF4, CD44
37vegf458.7PF4, FGF2, ANXA5, SELP, CD44, VCAM1
38prostacyclin458.7ICAM1, EDN1, PF4, FGF2, ACE, PTGIR
39oxygen45 249.6ITGAL, ITGA4, ANXA5, CD44, PF4, ICAM1
40cyclosporin a45 29 6010.6SELP, FGF2, CD44, ANXA5, ITGAL, EDN1
41aspirin45 50 29 2411.4ADIPOQ, SELP, ACE, PF4, CD63, ITGAL
42retinoic acid45 249.4ADIPOQ, ITGA4, HGF, SELP, VCAM1, ICAM1
43wortmannin458.4ADIPOQ, VCAM1, PF4, ITGA4, HGF, ITGAL
44cholesterol45 29 11 2411.1SELP, ITGAL, PF4, CD63, ACE, VCAM1
45fibrinogen458.1SELP, CD63, DUSP2, PF4, ICAM1, VCAM1
46nitric oxide45 11 2410.1CD63, CD44, ITGAL, ITGA4, ICAM1, EDN1
47lipid457.8HGF, ACE, ADIPOQ, VCAM1, PTGIR, PF4
48phosphatidylinositol457.4DUSP2, HGF, ICAM1, ITGA4, ITGAL, EDN1
49tyrosine456.9MCAM, FGF2, HGF, ITGA4, ICAM1, ITGAL
50calcium45 50 11 249.7ITGA4, ITGAL, EDN1, PF4, ANXA5, TPM1

GO Terms for genes affiliated with Arteriosclerosis Obliterans

Sources:
16Gene Ontology
See all sources

Cellular components related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1platelet dense granule membraneGO:0310889.6CD63, SELP
2cell surfaceGO:0099869.2ITGA4, CD44, CD63, VCAM1, ADIPOQ
3extracellular regionGO:0055768.7EDN1, CD2, PF4, FGF2, ACE, ADIPOQ
4extracellular spaceGO:0056158.5HGF, ICAM1, EDN1, PF4, FGF2, ACE
5external side of plasma membraneGO:0098977.9SELP, ICAM1, ITGA4, ITGAL, ANXA5, CD44
6plasma membraneGO:0058867.2ICAM1, ITGA4, ITGAL, CD44, CD2, CD63

Biological processes related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1membrane to membrane dockingGO:02261410.3VCAM1, ICAM1
2negative regulation of platelet-derived growth factor receptor signaling pathwayGO:01064210.3ADIPOQ, PTGIR
3chorio-allantoic fusionGO:06071010.2VCAM1, ITGA4
4T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cellGO:00229110.0ICAM1, ITGAL
5hyaluronan catabolic processGO:03021410.0FGF2, CD44
6negative regulation of hormone secretionGO:0468889.9ADIPOQ, EDN1
7interferon-gamma-mediated signaling pathwayGO:0603339.9VCAM1, CD44, ICAM1
8positive regulation of peptidyl-tyrosine phosphorylationGO:0507319.8HGF, CD44, ADIPOQ
9leukocyte tethering or rollingGO:0509019.8SELP, VCAM1
10cytokine-mediated signaling pathwayGO:0192219.6ICAM1, CD44, PF4, VCAM1
11platelet degranulationGO:0025769.6HGF, CD63, PF4, SELP
12regulation of immune responseGO:0507769.6VCAM1, ITGAL, ITGA4, ICAM1
13platelet activationGO:0301689.5HGF, CD63, PF4, SELP
14leukocyte cell-cell adhesionGO:0071599.5ICAM1, ITGA4, ITGAL, VCAM1, SELP
15heterophilic cell-cell adhesionGO:0071579.5ICAM1, ITGA4, ITGAL, VCAM1, SELP
16leukocyte migrationGO:0509009.5SELP, CD2, ITGAL, ITGA4, ICAM1
17cell adhesionGO:0071559.2ICAM1, ITGAL, MCAM, VCAM1, SELP
18blood coagulationGO:0075968.3SELP, HGF, ITGA4, ITGAL, ANXA5, CD2

Molecular functions related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sialic acid bindingGO:03369110.1ADIPOQ, SELP
2protein bindingGO:0055156.6ADIPOQ, HGF, ICAM1, EDN1, ITGA4, ITGAL

Products for genes affiliated with Arteriosclerosis Obliterans

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arteriosclerosis Obliterans

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet