MCID: ART008
MIFTS: 50

Arteriosclerosis Obliterans malady

Cardiovascular diseases category

Summaries for Arteriosclerosis Obliterans

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66Wikipedia, 34MalaCards
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Wikipedia:66 Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal... more...

MalaCards: Arteriosclerosis Obliterans is related to arteriosclerosis and diabetes mellitus. An important gene associated with Arteriosclerosis Obliterans is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Spinal Cord Injury and amb2 Integrin signaling. The drugs tolazoline and tolazoline hydrochloride and the compounds thiolutin and heparin sodium salt have been mentioned in the context of this disorder. Affiliated tissues include heart, skin and bone, and related mouse phenotypes are immune system and cellular.

Aliases & Classifications for Arteriosclerosis Obliterans

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 36MeSH
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

arteriosclerosis obliterans 9 11 46 63


External Ids:

Disease Ontology9 DOID:5160
SNOMED-CT59 361133006, 60625000
MeSH36 D001162

Related Diseases for Arteriosclerosis Obliterans

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Arteriosclerosis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.9HGF, VCAM1, ADIPOQ, ICAM1
2diabetes mellitus30.8SELP, ADIPOQ, ICAM1, VCAM1
3ischemia30.5HGF, SELP, ICAM1
4atherosclerosis30.4ICAM1, VCAM1, SELP, ADIPOQ
5peripheral vascular disease30.3VCAM1, SELP
6essential hypertension30.2ADIPOQ, SELP
7coronary artery disease30.2VCAM1, SELP, ADIPOQ
8type 2 diabetes mellitus30.2VCAM1, SELP, ADIPOQ
9vascular disease30.1ICAM1, ADIPOQ, VCAM1, SELP
10hypertension10.6
11thromboangiitis obliterans10.5
12aneurysm10.5
13aortic aneurysm10.4
14cerebritis10.3
15intermittent claudication10.3
16artery disease10.3
17myocardial infarction10.3
18wrinkles10.2
19chronic venous insufficiency10.2
20peripheral artery disease10.2
21abdominal aortic aneurysm10.2
22systemic lupus erythematosus10.2
23lupus erythematosus10.2
24purpura10.2
25thrombophlebitis10.2
26venous insufficiency10.2
27light chain deposition disease10.2
28cerebral arteriosclerosis10.2
29insulin resistance10.2
30blindness10.2
31endotheliitis10.2
32common cold10.1ICAM1
33malaria10.1ICAM1
34galactosemia10.1ICAM1
35antiphospholipid syndrome10.1VCAM1, SELP
36sickle cell disease10.0SELP, VCAM1
37immunoglobulin a vasculitis10.0ICAM1, VCAM1
38inclusion body myositis10.0VCAM1, ICAM1
39hyperhomocysteinemia10.0SELP, VCAM1
40rheumatoid vasculitis10.0ICAM1, VCAM1
41leukostasis10.0VCAM1, ICAM1
42oral lichen planus10.0ICAM1, VCAM1
43vernal keratoconjunctivitis10.0VCAM1, ICAM1
44monocytic leukemia10.0SELP, VCAM1
45coronary stenosis10.0ADIPOQ, SELP
46rhinitis10.0VCAM1, ICAM1
47lupus nephritis10.0ICAM1, VCAM1
48dermatomyositis10.0ICAM1, VCAM1
49polymyositis10.0ICAM1, VCAM1
50myositis10.0VCAM1, ICAM1

Graphical network of the top 20 diseases related to Arteriosclerosis Obliterans:



Diseases related to arteriosclerosis obliterans

Symptoms for Arteriosclerosis Obliterans

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Drugs & Therapeutics for Arteriosclerosis Obliterans

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Arteriosclerosis Obliterans

Drug clinical trials:

Search ClinicalTrials for Arteriosclerosis Obliterans

Search NIH Clinical Center for Arteriosclerosis Obliterans

Search CenterWatch for Arteriosclerosis Obliterans

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Arteriosclerosis Obliterans

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Anatomical Context for Arteriosclerosis Obliterans

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34MalaCards
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MalaCards organs/tissues related to Arteriosclerosis Obliterans:

34
Heart, Skin, Bone, Bone marrow, Spleen, Smooth muscle, Endothelial

Animal Models for Arteriosclerosis Obliterans or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Arteriosclerosis Obliterans:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1SELP, VCAM1, ADIPOQ, ICAM1
2MP:00053848.1HGF, ICAM1, ADIPOQ, SELP
3MP:00053857.6HGF, ICAM1, ADIPOQ, VCAM1, SELP
4MP:00053977.6SELP, VCAM1, ADIPOQ, ICAM1, HGF
5MP:00053787.5SELP, VCAM1, ADIPOQ, ICAM1, HGF
6MP:00107687.4HGF, ICAM1, ADIPOQ, VCAM1, SELP

Publications for Arteriosclerosis Obliterans

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53PubMed
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Articles related to Arteriosclerosis Obliterans:

(show top 50)    (show all 229)
idTitleAuthorsYear
1
Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients. (23749750)
2013
2
Retrograde perfusion of the hind leg in diabetic patients suffering from arteriosclerosis obliterans: theoretical considerations of oxygen supply and lymphatic flow based on rat models. (22259111)
2012
3
A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol. (23097651)
2012
4
Study design of SEASON registry: prospective Surveillance of cardiovascular Events in an Antiplatelet-treated arterioSclerosis Obliterans patients in JapaN )SEASON). (20966606)
2010
5
Long-term follow-up of Symphony nitinol stents in iliac arteriosclerosis obliterans. (18270875)
2008
6
Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans. (18175063)
2008
7
Cost-effectiveness of Liple (LipoPGE1) for arteriosclerosis obliterans patients in Japan: an economic evaluation using the EQ-5D instrument. (16763534)
2006
8
Low-density lipoprotein apheresis in a patient with arteriosclerosis obliterans and light chain deposition disease. (15224807)
2004
9
Three cases of ischemic ulcer due to arteriosclerosis obliterans responding to basic fibroblast growth factor spray. (15372302)
2004
10
Effect of the serotonin blocker sarpogrelate on circulating interleukin-18 levels in patients with diabetes and arteriosclerosis obliterans. (15080020)
2004
11
Estimating the stenosis probabilities in arteriosclerosis obliterans using generalized estimating equations. (12820280)
2003
12
A case of arteriosclerosis obliterans with monitored regional oxygen saturation during treatment with a lumbar sympathetic ganglion block. (14556145)
2003
13
Usefulness of the Symphony Nitinol Stent for arteriosclerosis obliterans. (12419929)
2002
14
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. (9698948)
1998
15
Insulin resistance and arteriosclerosis obliterans in patients with NIDDM. (9353618)
1997
16
Hemodynamic changes in the lower limbs during treadmill walking in normal subjects and in patients with arteriosclerosis obliterans. (9313629)
1997
17
Comparison of arteriosclerosis obliterans of lower limbs between China and Japan. (2225282)
1990
18
Dipyridamole and aspirin in arteriosclerosis obliterans of the lower limbs. (3159212)
1985
19
beta-Pyridylcarbinol (Ronicol) releases a prostacyclin-like substance into arterial blood of patients with arteriosclerosis obliterans. (6346344)
1983
20
Prevalence of severe arteriosclerosis obliterans in patients with diabetes mellitus. Relation to smoking and form of therapy. (7052035)
1982
21
Lack of effect of ischemia and dipyridamole on prostacyclin production in arteriosclerosis obliterans. (7041195)
1981
22
Successful therapy of advanced arteriosclerosis obliterans with prostacyclin. (86835)
1979
23
Serum lipids and lipoproteins in arteriosclerosis obliterans of the lower extremities. (750857)
1978
24
Factors influenced on prognosis of reconstructive surgery for peripheral arterial occlusion: comparative study between arteriosclerosis obliterans and thromboangiitis obliterans. (599159)
1977
25
Applications of ultrasound to the study of arteriosclerosis obliterans. (1090218)
1975
26
Double-blind crossoer clinical trial of pyridinolcarbamate in peripheral arterial disease (arteriosclerosis obliterans). (4570447)
1973
27
Saphenous vein bypass grafts for arteriosclerosis obliterans in the femoropopliteal region. (4695292)
1973
28
Cigarette smoking and arteriosclerosis obliterans: an epidemiologic approach. (5007359)
1972
29
Lumbar sympathectomy for arteriosclerosis obliterans. (5419582)
1970
30
The natural course of peripheral arteriosclerosis obliterans evaluated by flow measurements. (5802451)
1969
31
A diagnostic aid for determining peripheral arteriosclerosis obliterans. (6058444)
1967
32
Pulse morphological plethysmography of the forefoot in arteriosclerosis obliterans. (6056910)
1967
33
Thromboangiitis obliterans and arteriosclerosis obliterans. (5833515)
1965
34
LUMBAR SYMPATHECTOMY IN ARTERIOSCLEROSIS OBLITERANS. (14179033)
1964
35
THROMBOANGIITIS OBLITERANS AND ARTERIOSCLEROSIS OBLITERANS. CLINICAL AND PROGNOSTIC DIFFERENCES. (14065946)
1963
36
A COMPARISON OF THE NATURAL HISTORY OF ARTERIOSCLEROSIS OBLITERANS WITH THE RESULTS OF ARTERIAL RECONSTRUCTION. (14053194)
1963
37
A CLINICAL EVALUATION OF DIETHANOLAMINE SALT OF P-TOLYLMETHYLCARBINOL CAMPHORIC ACID (GALLOGEN) IN ARTERIOSCLEROSIS OBLITERANS. (14047141)
1963
38
Severe ischemia of lower extremity due to arteriosclerosis obliterans. (13955713)
1963
39
Treatment of diabetic ulcer with concomitant arteriosclerosis obliterans. (14424139)
1960
40
Iliofemoropopliteal arterial reconstructions for arteriosclerosis obliterans; factors influencing late patency. (13622959)
1959
41
Arteriosclerosis obliterans of the lower extremity. (13620974)
1959
42
Oxygen utilization and lactic acid formation in the legs at rest and during exercise in normal subjects and in patients with arteriosclerosis obliterans. (13660772)
1959
43
Arteriosclerosis obliterans. (13640435)
1959
44
Muscle blood flow in patients with arteriosclerosis obliterans. (13559561)
1958
45
Coronary (ischaemic) heart disease in patients with arteriosclerosis obliterans. (13394194)
1956
46
An approach to the etiology, diagnosis and management of peripheral arteriosclerosis (arteriosclerosis obliterans). (13318639)
1956
47
Use of vasodilator drugs in the treatment of diabetic arteriosclerosis obliterans. (13162729)
1954
48
CLINICAL pathologic conference: diabetes mellitus with complications, including generalized arteriosclerosis, cerebral arteriosclerosis, coronary arteriosclerosis, hypertensive cardiovascular disease and arteriosclerosis obliterans of the extremities. (13011459)
1952
49
An evaluation of roniacol tartrate in arteriosclerosis obliterans. (14843421)
1951
50
Arteriosclerosis obliterans of the abdominal aorta. (20999992)
1946

Variations for Arteriosclerosis Obliterans

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Expression for genes affiliated with Arteriosclerosis Obliterans

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arteriosclerosis Obliterans

Search GEO for disease gene expression data for Arteriosclerosis Obliterans.

Pathways for genes affiliated with Arteriosclerosis Obliterans

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Sources:
51PathCards, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology, 56Reactome, 54QIAGEN, 61Thomson Reuters
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Pathways related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5SELP, ICAM1
29.5ICAM1, SELP
39.5SELP, ICAM1
49.4ICAM1, VCAM1
59.4VCAM1, ICAM1
69.4ICAM1, VCAM1
7
Show member pathways
RANKL/RANK Signaling Pathway39
Apoptosis and survival APRIL and BAFF signaling61
9.4VCAM1, ICAM1
89.4ICAM1, VCAM1
99.4VCAM1, ICAM1
10
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
9.4VCAM1, ICAM1
119.4ICAM1, VCAM1
129.4VCAM1, ICAM1
139.4VCAM1, ICAM1
149.4ICAM1, VCAM1
159.4VCAM1, ICAM1
169.4VCAM1, ICAM1
17
Show member pathways
9.2HGF, SELP
189.0VCAM1, SELP, ICAM1
19
Show member pathways
8.6HGF, VCAM1, ICAM1
208.2ICAM1, SELP, VCAM1, HGF

Compounds for genes affiliated with Arteriosclerosis Obliterans

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Sources:
62Tocris Bioscience, 30IUPHAR, 46Novoseek, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB
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Compounds related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1thiolutin629.8SELP, ICAM1
2heparin sodium salt629.7SELP, ICAM1
3echistatin, alpha1 isoform629.7SELP, ICAM1
4rgds peptide629.7SELP, ICAM1
5sarpogrelate30 4610.7SELP, ADIPOQ
6ac2-26629.7ICAM1, SELP
7tetramethylpyrazine469.6SELP, ICAM1
8slea469.5ICAM1, SELP
9sele469.4ICAM1, VCAM1, SELP
10cuprophan469.4SELP, VCAM1, ICAM1
11slex469.4ICAM1, VCAM1, SELP
12budesonide46 52 1211.4SELP, ICAM1, VCAM1
13pentoxifylline46 1210.3ICAM1, SELP, VCAM1
14fluvastatin46 52 30 1212.3SELP, ICAM1, VCAM1
15mannitol46 1210.2SELP, ICAM1, VCAM1
16gliclazide46 52 1211.2VCAM1, ADIPOQ, ICAM1
17pdmp469.2ICAM1, SELP
188-isoprostane469.2VCAM1, ADIPOQ, ICAM1
19homocysteine46 2510.2ADIPOQ, SELP, VCAM1
20cilostazol46 1210.1HGF, VCAM1, SELP
21dextran sulfate469.0HGF, SELP, ICAM1
22cocaine46 1210.0VCAM1, ADIPOQ, SELP
23troglitazone46 30 62 1212.0ADIPOQ, ICAM1, VCAM1
24pdtc468.9ICAM1, VCAM1, HGF
25sp 60012546 629.9ICAM1, VCAM1, HGF
26carbohydrates468.9VCAM1, SELP, ADIPOQ
27fenofibrate46 52 1210.8ADIPOQ, VCAM1, ICAM1, SELP
28pravastatin46 52 30 25 1212.8SELP, ICAM1, VCAM1, ADIPOQ
29atorvastatin46 52 30 25 1212.8ADIPOQ, ICAM1, SELP, VCAM1
30simvastatin46 52 62 30 25 1213.8SELP, VCAM1, ADIPOQ, ICAM1
31rantes468.8SELP, VCAM1, ADIPOQ, ICAM1
32fibrinogen468.7SELP, VCAM1, ADIPOQ, ICAM1
33n acetylcysteine468.6HGF, ICAM1, SELP, VCAM1
34polysaccharide468.5ICAM1, VCAM1, HGF, SELP
35histamine46 30 2510.5VCAM1, SELP, ICAM1, HGF
36herbimycin a46 629.5ICAM1, HGF, VCAM1
37genistein46 30 62 3 25 1213.5VCAM1, ICAM1, HGF, SELP
38losartan46 52 30 1211.5HGF, ADIPOQ, VCAM1, SELP
39sodium nitroprusside468.5VCAM1, ADIPOQ, HGF, SELP
40norepinephrine46 25 1210.4HGF, VCAM1, SELP, ADIPOQ
41aspartate468.4HGF, SELP, VCAM1, ADIPOQ
42sb 20358046 629.4VCAM1, ICAM1, ADIPOQ, HGF
43heparin46 30 25 1211.4SELP, HGF, ADIPOQ, VCAM1
44adenylate468.4HGF, ADIPOQ, SELP, VCAM1
45prostacyclin468.0ADIPOQ, ICAM1, HGF, SELP, VCAM1
46ly294002468.0SELP, VCAM1, ADIPOQ, HGF, ICAM1
47pge2468.0VCAM1, ADIPOQ, ICAM1, HGF, SELP
48lactate468.0ADIPOQ, HGF, SELP, ICAM1, VCAM1
49dexamethasone46 52 30 1211.0SELP, VCAM1, ADIPOQ, ICAM1, HGF
50retinoic acid46 258.9HGF, SELP, ICAM1, ADIPOQ, VCAM1

GO Terms for genes affiliated with Arteriosclerosis Obliterans

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17Gene Ontology
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Cellular components related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0ICAM1, VCAM1, SELP
2extracellular spaceGO:0056157.2HGF, ICAM1, ADIPOQ, VCAM1, SELP

Biological processes related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:0509019.8VCAM1, SELP
2membrane to membrane dockingGO:0226149.7ICAM1, VCAM1
3cellular response to glucose stimulusGO:0713339.7ICAM1, VCAM1
4response to ionizing radiationGO:0102129.7VCAM1, ICAM1
5cellular response to tumor necrosis factorGO:0713569.6ICAM1, VCAM1
6interferon-gamma-mediated signaling pathwayGO:0603339.5VCAM1, ICAM1
7response to lipopolysaccharideGO:0324969.5VCAM1, SELP
8response to nutrientGO:0075849.4ADIPOQ, VCAM1
9positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4HGF, SELP
10cell chemotaxisGO:0603269.3VCAM1, HGF
11regulation of immune responseGO:0507769.3VCAM1, ICAM1
12leukocyte cell-cell adhesionGO:0071599.3SELP, VCAM1, ICAM1
13heterophilic cell-cell adhesionGO:0071579.3ICAM1, VCAM1, SELP
14cell adhesionGO:0071559.2SELP, ICAM1, VCAM1
15platelet degranulationGO:0025769.2HGF, SELP
16leukocyte migrationGO:0509009.2SELP, ICAM1
17response to ethanolGO:0454719.1VCAM1, ADIPOQ, ICAM1
18positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8ADIPOQ, ICAM1, HGF

Molecular functions related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.4ICAM1, VCAM1
2sialic acid bindingGO:0336919.1ADIPOQ, SELP

Products for genes affiliated with Arteriosclerosis Obliterans

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arteriosclerosis Obliterans

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet