MCID: ART008
MIFTS: 50

Arteriosclerosis Obliterans malady

Cardiovascular diseases category

Summaries for Arteriosclerosis Obliterans

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Wikipedia:64 Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal... more...

MalaCards based summary: Arteriosclerosis Obliterans is related to arteriosclerosis and peripheral vascular disease. An important gene associated with Arteriosclerosis Obliterans is SELP (selectin P (granule membrane protein 140kDa, antigen CD62)), and among its related pathways are Spinal Cord Injury and amb2 Integrin signaling. The drugs tolazoline and tolazoline hydrochloride and the compounds thiolutin and heparin sodium salt have been mentioned in the context of this disorder. Affiliated tissues include heart, bone marrow and bone, and related mouse phenotypes are immune system and cellular.

Aliases & Classifications for Arteriosclerosis Obliterans

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Arteriosclerosis Obliterans, Aliases & Descriptions:

Name: Arteriosclerosis Obliterans 9 11 44 61


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:5160
SNOMED-CT56 361133006, 60625000
MeSH34 D001162

Related Diseases for Arteriosclerosis Obliterans

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Diseases related to Arteriosclerosis Obliterans via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 88)
idRelated DiseaseScoreTop Affiliating Genes
1arteriosclerosis31.4VCAM1, ADIPOQ, ICAM1, HGF
2peripheral vascular disease30.6SELP, VCAM1
3diabetes mellitus30.5ICAM1, ADIPOQ, VCAM1, SELP
4ischemia30.4SELP, ICAM1, HGF
5essential hypertension30.3ADIPOQ, SELP
6type 2 diabetes mellitus30.2ADIPOQ, VCAM1, SELP
7atherosclerosis30.1SELP, VCAM1, ADIPOQ, ICAM1
8vascular disease29.9SELP, VCAM1, ADIPOQ, ICAM1
9hypertension10.6
10thromboangiitis obliterans10.5
11aneurysm10.5
12common cold10.4ICAM1
13malaria10.4ICAM1
14aortic aneurysm10.4
15galactosemia10.3ICAM1
16intermittent claudication10.3
17ischemic heart disease10.3
18myocardial infarction10.3
19cerebritis10.3
20artery disease10.3
21antiphospholipid syndrome10.2VCAM1, SELP
22immunoglobulin a vasculitis10.2ICAM1, VCAM1
23sickle cell disease10.2SELP, VCAM1
24inclusion body myositis10.2VCAM1, ICAM1
25hyperhomocysteinemia10.2VCAM1, SELP
26rheumatoid vasculitis10.2ICAM1, VCAM1
27leukostasis10.2ICAM1, VCAM1
28oral lichen planus10.2ICAM1, VCAM1
29vernal keratoconjunctivitis10.2VCAM1, ICAM1
30monocytic leukemia10.2SELP, VCAM1
31coronary stenosis10.2ADIPOQ, SELP
32rhinitis10.2ICAM1, VCAM1
33lupus nephritis10.2VCAM1, ICAM1
34dermatomyositis10.2VCAM1, ICAM1
35polymyositis10.2ICAM1, VCAM1
36myositis10.2VCAM1, ICAM1
37synovitis10.2ICAM1, VCAM1
38systemic lupus erythematosus10.2
39wrinkles10.2
40abdominal aortic aneurysm10.2
41peripheral artery disease10.2
42lupus erythematosus10.2
43purpura10.2
44light chain deposition disease10.2
45cerebral arteriosclerosis10.2
46insulin resistance10.2
47blindness10.2
48endotheliitis10.2
49diabetic retinopathy10.2ICAM1, VCAM1
50connective tissue disease10.2VCAM1, ICAM1

Graphical network of the top 20 diseases related to Arteriosclerosis Obliterans:



Diseases related to arteriosclerosis obliterans

Symptoms for Arteriosclerosis Obliterans

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Drugs & Therapeutics for Arteriosclerosis Obliterans

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Drug clinical trials:

Search ClinicalTrials for Arteriosclerosis Obliterans

Search NIH Clinical Center for Arteriosclerosis Obliterans

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Arteriosclerosis Obliterans

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Anatomical Context for Arteriosclerosis Obliterans

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MalaCards organs/tissues related to Arteriosclerosis Obliterans:

32
Heart, Bone marrow, Bone, Skin, Spleen, Smooth muscle, T cells, Endothelial

Animal Models for Arteriosclerosis Obliterans or affiliated genes

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MGI Mouse Phenotypes related to Arteriosclerosis Obliterans:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053878.1SELP, VCAM1, ADIPOQ, ICAM1
2MP:00053848.1HGF, ICAM1, ADIPOQ, SELP
3MP:00053857.6HGF, ICAM1, ADIPOQ, VCAM1, SELP
4MP:00053977.6SELP, VCAM1, ADIPOQ, ICAM1, HGF
5MP:00053787.5SELP, VCAM1, ADIPOQ, ICAM1, HGF
6MP:00107687.4HGF, ICAM1, ADIPOQ, VCAM1, SELP

Publications for Arteriosclerosis Obliterans

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Articles related to Arteriosclerosis Obliterans:

(show top 50)    (show all 227)
idTitleAuthorsYear
1
MiR-142-3p attenuates the migration of CD4a8_ T cells through regulating actin cytoskeleton via RAC1 and ROCK2 in arteriosclerosis obliterans. (24743945)
2014
2
Long-term effects of beraprost sodium on arteriosclerosis obliterans: a single-center retrospective study of Japanese patients. (23749750)
2013
3
Retrograde perfusion of the hind leg in diabetic patients suffering from arteriosclerosis obliterans: theoretical considerations of oxygen supply and lymphatic flow based on rat models. (22259111)
2012
4
A randomized, open-label, multicentre study to evaluate plasma atherosclerotic biomarkers in patients with type 2 diabetes mellitus and arteriosclerosis obliterans when treated with Probucol and Cilostazol. (23097651)
2012
5
Study design of SEASON registry: prospective Surveillance of cardiovascular Events in an Antiplatelet-treated arterioSclerosis Obliterans patients in JapaN )SEASON). (20966606)
2010
6
Long-term follow-up of Symphony nitinol stents in iliac arteriosclerosis obliterans. (18270875)
2008
7
Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans. (18175063)
2008
8
Cost-effectiveness of Liple (LipoPGE1) for arteriosclerosis obliterans patients in Japan: an economic evaluation using the EQ-5D instrument. (16763534)
2006
9
Low-density lipoprotein apheresis in a patient with arteriosclerosis obliterans and light chain deposition disease. (15224807)
2004
10
Three cases of ischemic ulcer due to arteriosclerosis obliterans responding to basic fibroblast growth factor spray. (15372302)
2004
11
Effect of the serotonin blocker sarpogrelate on circulating interleukin-18 levels in patients with diabetes and arteriosclerosis obliterans. (15080020)
2004
12
Estimating the stenosis probabilities in arteriosclerosis obliterans using generalized estimating equations. (12820280)
2003
13
A case of arteriosclerosis obliterans with monitored regional oxygen saturation during treatment with a lumbar sympathetic ganglion block. (14556145)
2003
14
Usefulness of the Symphony Nitinol Stent for arteriosclerosis obliterans. (12419929)
2002
15
The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. (9698948)
1998
16
Insulin resistance and arteriosclerosis obliterans in patients with NIDDM. (9353618)
1997
17
Hemodynamic changes in the lower limbs during treadmill walking in normal subjects and in patients with arteriosclerosis obliterans. (9313629)
1997
18
Comparison of arteriosclerosis obliterans of lower limbs between China and Japan. (2225282)
1990
19
beta-Pyridylcarbinol (Ronicol) releases a prostacyclin-like substance into arterial blood of patients with arteriosclerosis obliterans. (6346344)
1983
20
Prevalence of severe arteriosclerosis obliterans in patients with diabetes mellitus. Relation to smoking and form of therapy. (7052035)
1982
21
Lack of effect of ischemia and dipyridamole on prostacyclin production in arteriosclerosis obliterans. (7041195)
1981
22
Successful therapy of advanced arteriosclerosis obliterans with prostacyclin. (86835)
1979
23
Serum lipids and lipoproteins in arteriosclerosis obliterans of the lower extremities. (750857)
1978
24
Factors influenced on prognosis of reconstructive surgery for peripheral arterial occlusion: comparative study between arteriosclerosis obliterans and thromboangiitis obliterans. (599159)
1977
25
Applications of ultrasound to the study of arteriosclerosis obliterans. (1090218)
1975
26
Double-blind crossoer clinical trial of pyridinolcarbamate in peripheral arterial disease (arteriosclerosis obliterans). (4570447)
1973
27
Saphenous vein bypass grafts for arteriosclerosis obliterans in the femoropopliteal region. (4695292)
1973
28
Cigarette smoking and arteriosclerosis obliterans: an epidemiologic approach. (5007359)
1972
29
Lumbar sympathectomy for arteriosclerosis obliterans. (5419582)
1970
30
The natural course of peripheral arteriosclerosis obliterans evaluated by flow measurements. (5802451)
1969
31
A diagnostic aid for determining peripheral arteriosclerosis obliterans. (6058444)
1967
32
Pulse morphological plethysmography of the forefoot in arteriosclerosis obliterans. (6056910)
1967
33
Thromboangiitis obliterans and arteriosclerosis obliterans. (5833515)
1965
34
LUMBAR SYMPATHECTOMY IN ARTERIOSCLEROSIS OBLITERANS. (14179033)
1964
35
THROMBOANGIITIS OBLITERANS AND ARTERIOSCLEROSIS OBLITERANS. CLINICAL AND PROGNOSTIC DIFFERENCES. (14065946)
1963
36
A COMPARISON OF THE NATURAL HISTORY OF ARTERIOSCLEROSIS OBLITERANS WITH THE RESULTS OF ARTERIAL RECONSTRUCTION. (14053194)
1963
37
A CLINICAL EVALUATION OF DIETHANOLAMINE SALT OF P-TOLYLMETHYLCARBINOL CAMPHORIC ACID (GALLOGEN) IN ARTERIOSCLEROSIS OBLITERANS. (14047141)
1963
38
Severe ischemia of lower extremity due to arteriosclerosis obliterans. (13955713)
1963
39
Treatment of diabetic ulcer with concomitant arteriosclerosis obliterans. (14424139)
1960
40
Iliofemoropopliteal arterial reconstructions for arteriosclerosis obliterans; factors influencing late patency. (13622959)
1959
41
Arteriosclerosis obliterans of the lower extremity. (13620974)
1959
42
Oxygen utilization and lactic acid formation in the legs at rest and during exercise in normal subjects and in patients with arteriosclerosis obliterans. (13660772)
1959
43
Arteriosclerosis obliterans. (13640435)
1959
44
Muscle blood flow in patients with arteriosclerosis obliterans. (13559561)
1958
45
Coronary (ischaemic) heart disease in patients with arteriosclerosis obliterans. (13394194)
1956
46
An approach to the etiology, diagnosis and management of peripheral arteriosclerosis (arteriosclerosis obliterans). (13318639)
1956
47
Use of vasodilator drugs in the treatment of diabetic arteriosclerosis obliterans. (13162729)
1954
48
CLINICAL pathologic conference: diabetes mellitus with complications, including generalized arteriosclerosis, cerebral arteriosclerosis, coronary arteriosclerosis, hypertensive cardiovascular disease and arteriosclerosis obliterans of the extremities. (13011459)
1952
49
An evaluation of roniacol tartrate in arteriosclerosis obliterans. (14843421)
1951
50
Arteriosclerosis obliterans of the abdominal aorta. (20999992)
1946

Variations for Arteriosclerosis Obliterans

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Expression for genes affiliated with Arteriosclerosis Obliterans

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Expression patterns in normal tissues for genes affiliated with Arteriosclerosis Obliterans

Search GEO for disease gene expression data for Arteriosclerosis Obliterans.

Pathways for genes affiliated with Arteriosclerosis Obliterans

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Pathways related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5ICAM1, SELP
29.5ICAM1, SELP
39.5SELP, ICAM1
49.4VCAM1, ICAM1
59.4VCAM1, ICAM1
69.4ICAM1, VCAM1
7
Show member pathways
RANKL/RANK Signaling Pathway37
Apoptosis and survival APRIL and BAFF signaling59
9.4ICAM1, VCAM1
89.4ICAM1, VCAM1
99.4VCAM1, ICAM1
10
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades59
9.4ICAM1, VCAM1
119.4ICAM1, VCAM1
129.4ICAM1, VCAM1
139.4ICAM1, VCAM1
149.4VCAM1, ICAM1
159.4ICAM1, VCAM1
169.4ICAM1, VCAM1
17
Show member pathways
9.2HGF, SELP
189.0SELP, VCAM1, ICAM1
19
Show member pathways
8.6VCAM1, ICAM1, HGF
208.2HGF, ICAM1, VCAM1, SELP

Compounds for genes affiliated with Arteriosclerosis Obliterans

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Compounds related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1thiolutin609.8SELP, ICAM1
2heparin sodium salt609.7SELP, ICAM1
3echistatin, alpha1 isoform609.7SELP, ICAM1
4rgds peptide609.7SELP, ICAM1
5sarpogrelate29 4410.7SELP, ADIPOQ
6ac2-26609.7ICAM1, SELP
7tetramethylpyrazine449.6SELP, ICAM1
8slea449.5ICAM1, SELP
9sele449.4ICAM1, VCAM1, SELP
10cuprophan449.4SELP, VCAM1, ICAM1
11slex449.4ICAM1, VCAM1, SELP
12budesonide44 50 1211.4SELP, ICAM1, VCAM1
13pentoxifylline44 1210.3ICAM1, SELP, VCAM1
14fluvastatin44 50 29 1212.3SELP, ICAM1, VCAM1
15mannitol44 1210.2SELP, ICAM1, VCAM1
16gliclazide44 50 1211.2VCAM1, ADIPOQ, ICAM1
17pdmp449.2ICAM1, SELP
188-isoprostane449.2VCAM1, ADIPOQ, ICAM1
19homocysteine44 2510.2ADIPOQ, SELP, VCAM1
20cilostazol44 1210.1HGF, VCAM1, SELP
21dextran sulfate449.0HGF, SELP, ICAM1
22cocaine44 1210.0VCAM1, ADIPOQ, SELP
23troglitazone44 29 60 1212.0ADIPOQ, ICAM1, VCAM1
24pdtc448.9ICAM1, VCAM1, HGF
25sp 60012544 609.9ICAM1, VCAM1, HGF
26carbohydrates448.9VCAM1, SELP, ADIPOQ
27fenofibrate44 50 1210.8ADIPOQ, VCAM1, ICAM1, SELP
28pravastatin44 50 29 25 1212.8SELP, ICAM1, VCAM1, ADIPOQ
29atorvastatin44 50 29 25 1212.8ADIPOQ, ICAM1, SELP, VCAM1
30simvastatin44 50 60 29 25 1213.8SELP, VCAM1, ADIPOQ, ICAM1
31rantes448.8SELP, VCAM1, ADIPOQ, ICAM1
32fibrinogen448.7SELP, VCAM1, ADIPOQ, ICAM1
33n acetylcysteine448.6HGF, ICAM1, SELP, VCAM1
34polysaccharide448.5ICAM1, VCAM1, HGF, SELP
35histamine44 29 2510.5VCAM1, SELP, ICAM1, HGF
36herbimycin a44 609.5ICAM1, HGF, VCAM1
37genistein44 29 60 3 25 1213.5VCAM1, ICAM1, HGF, SELP
38losartan44 50 29 1211.5HGF, ADIPOQ, VCAM1, SELP
39sodium nitroprusside448.5VCAM1, ADIPOQ, HGF, SELP
40norepinephrine44 25 1210.4HGF, VCAM1, SELP, ADIPOQ
41aspartate448.4HGF, SELP, VCAM1, ADIPOQ
42sb 20358044 609.4VCAM1, ICAM1, ADIPOQ, HGF
43heparin44 29 25 1211.4SELP, HGF, ADIPOQ, VCAM1
44adenylate448.4HGF, ADIPOQ, SELP, VCAM1
45prostacyclin448.0ADIPOQ, ICAM1, HGF, SELP, VCAM1
46ly294002448.0SELP, VCAM1, ADIPOQ, HGF, ICAM1
47pge2448.0VCAM1, ADIPOQ, ICAM1, HGF, SELP
48lactate448.0ADIPOQ, HGF, SELP, ICAM1, VCAM1
49dexamethasone44 50 29 1211.0SELP, VCAM1, ADIPOQ, ICAM1, HGF
50retinoic acid44 258.9HGF, SELP, ICAM1, ADIPOQ, VCAM1

GO Terms for genes affiliated with Arteriosclerosis Obliterans

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Cellular components related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.0ICAM1, VCAM1, SELP
2extracellular spaceGO:0056157.2HGF, ICAM1, ADIPOQ, VCAM1, SELP

Biological processes related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1leukocyte tethering or rollingGO:0509019.8VCAM1, SELP
2membrane to membrane dockingGO:0226149.7ICAM1, VCAM1
3cellular response to glucose stimulusGO:0713339.7ICAM1, VCAM1
4response to ionizing radiationGO:0102129.7ICAM1, VCAM1
5cellular response to tumor necrosis factorGO:0713569.6ICAM1, VCAM1
6interferon-gamma-mediated signaling pathwayGO:0603339.5VCAM1, ICAM1
7response to lipopolysaccharideGO:0324969.5VCAM1, SELP
8response to nutrientGO:0075849.4ADIPOQ, VCAM1
9positive regulation of phosphatidylinositol 3-kinase signalingGO:0140689.4SELP, HGF
10cell chemotaxisGO:0603269.3HGF, VCAM1
11regulation of immune responseGO:0507769.3VCAM1, ICAM1
12leukocyte cell-cell adhesionGO:0071599.3ICAM1, VCAM1, SELP
13heterophilic cell-cell adhesionGO:0071579.3SELP, VCAM1, ICAM1
14cell adhesionGO:0071559.2SELP, VCAM1, ICAM1
15platelet degranulationGO:0025769.2HGF, SELP
16leukocyte migrationGO:0509009.2ICAM1, SELP
17response to ethanolGO:0454719.1VCAM1, ADIPOQ, ICAM1
18positive regulation of peptidyl-tyrosine phosphorylationGO:0507318.8HGF, ICAM1, ADIPOQ

Molecular functions related to Arteriosclerosis Obliterans according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integrin bindingGO:0051789.4ICAM1, VCAM1
2sialic acid bindingGO:0336919.1ADIPOQ, SELP

Products for genes affiliated with Arteriosclerosis Obliterans

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Sources for Arteriosclerosis Obliterans

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
29IUPHAR
30KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet