Aliases & Classifications for Arteriovenous Malformation

MalaCards integrated aliases for Arteriovenous Malformation:

Name: Arteriovenous Malformation 12 72 50 28 14
Arteriovenous Malformations 51 40
Arteriovenous Hemangioma 12 69
Congenital Arteriovenous Malformation 69
Racemose Hemangioma 12
Racemose Aneurysm 12
Cirsoid Aneurysm 12
Racemose Angioma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11294
ICD10 32 I77.0
NCIt 46 C2882

Summaries for Arteriovenous Malformation

MedlinePlus : 40 Arteriovenous malformations (AVMs) are defects in your vascular system. The vascular system includes arteries, veins, and capillaries. Arteries carry blood away from the heart to other organs; veins carry blood back to the heart. Capillaries connect the arteries and veins. An AVM is a snarled tangle of arteries and veins. They are connected to each other, with no capillaries. That interferes with the blood circulation in an organ. AVMs can happen anywhere, but they are more common in the brain or spinal cord. Most people with brain or spinal cord AVMs have few, if any, major symptoms. Sometimes they can cause seizures or headaches. AVMs are rare. The cause is not known, but they seem to develop during pregnancy or soon after birth. Doctors use imaging tests to detect them. Medicines can help with the symptoms from AVMs. The greatest danger is hemorrhage. Treatment for AVMs can include surgery or focused radiation therapy. Because surgery can be risky, you and your doctor need to make a decision carefully. NIH: National Institute of Neurological Disorders and Stroke

MalaCards based summary : Arteriovenous Malformation, also known as arteriovenous malformations, is related to capillary malformation-arteriovenous malformation and arteriovenous malformations of the brain, and has symptoms including sleeplessness, vertigo/dizziness and chronic pain. An important gene associated with Arteriovenous Malformation is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are GPCR Pathway and ERK Signaling. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related phenotypes are cardiovascular system and growth/size/body region

NINDS : 50 Arteriovenous malformations (AVMs) are abnormal, snarled tangles of blood vessels that cause multiple irregular connections between the arteries and veins.  These malformations most often occur in the spinal cord and in any part of the brain or on its surface, but can develop elsewhere in the body. AVMs can damage the brain and spinal cord by reducing the amount of oxygen reaching neurological tissues, bleeding into surrounding tissue (hemorrhage) that can cause stroke or brain damage, and by compressing or displacing parts of the brain or spinal cord.  Many people with an AVM experience few, if any, significant symptoms, which can include headache, weakness, seizures, pain, and problems with speech, vision, or movement.  Most often AVMs are congenital, but they can appear sporadically.  In some cases the AVM may be inherited, but it is more likely that other inherited conditions increase the risk of having an AVM.  The malformations tend to be discovered only incidentally, usually during treatment for an unrelated disorder or at autopsy.

Disease Ontology : 12 An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system.

Wikipedia : 72 Arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the... more...

Related Diseases for Arteriovenous Malformation

Diseases related to Arteriovenous Malformation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 333)
# Related Disease Score Top Affiliating Genes
1 capillary malformation-arteriovenous malformation 34.6 EPHB4 RASA1
2 arteriovenous malformations of the brain 34.4 ACVRL1 ENG IL6
3 pulmonary arteriovenous malformation 34.4 ACVRL1 ENG
4 hereditary hemorrhagic telangiectasia 31.8 ACVRL1 BMPR2 ENG VEGFA
5 arteriovenous fistula 30.8 IL6 RASA1
6 weber syndrome 30.8 ACVRL1 ENG RASA1
7 brain edema 30.2 IL6 MMP9 VEGFA
8 angiodysplasia 30.1 ACVRL1 ENG VEGFA
9 immune hydrops fetalis 29.9 EPHB4 RASA1
10 pulmonary hypertension, primary, 1 29.7 ACVRL1 BMPR2 ENG
11 malignant glioma 29.7 MMP9 PTEN VEGFA
12 astrocytoma 29.5 IL6 MMP9 PTEN VEGFA
13 pulmonary hypertension 29.2 ACVRL1 BMPR2 ENG IL6 VEGFA
14 myocardial infarction 28.9 ENG IL6 MMP3 MMP9 VEGFA
15 telangiectasis 28.7 ACVRL1 BMPR2 ENG RASA1 VEGFA
16 extracranial arteriovenous malformation 12.4
17 mandibular arteriovenous malformation 12.2
18 maxillary arteriovenous malformation 12.2
19 facial arteriovenous malformation 12.1
20 frontonasal arteriovenous malformation 12.1
21 segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome 12.1
22 vein of galen aneurysm 12.0
23 cobb syndrome 11.6
24 juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome 11.6
25 pulmonary arteriovenous fistulas 11.5
26 telangiectasia, hereditary hemorrhagic, type 1 11.5
27 telangiectasia, hereditary hemorrhagic, type 2 11.4
28 pulmonary arterio-veinous fistula 11.4
29 wyburn mason's syndrome 11.3
30 parkes weber syndrome 11.3
31 cerebral cavernous malformations 11.2
32 telangiectasia, hereditary hemorrhagic, type 5 11.2
33 congenital lipomatous overgrowth, vascular malformations, and epidermal nevi 11.1
34 dural sinus malformation 11.0
35 noonan syndrome 1 10.9
36 hemorrhage, intracerebral 10.9
37 paroxysmal hemicrania 10.9
38 superficial siderosis of the central nervous system 10.9
39 cerebritis 10.7
40 aneurysm 10.5
41 glomeruloid hemangioma 10.4 ENG VEGFA
42 skin hemangioma 10.4 RASA1 VEGFA
43 critical limb ischemia 10.4 IL6 VEGFA
44 sick building syndrome 10.4 MMP9 VEGFA
45 capillary hemangioma 10.4 RASA1 VEGFA
46 rheumatoid nodulosis 10.4 MMP3 MMP9
47 diabetic foot ulcers 10.4 IL6 MMP9
48 adamantinous craniopharyngioma 10.4 MMP9 VEGFA
49 acute transverse myelitis 10.4 IL6 MMP9
50 spinal disease 10.4 IL6 VEGFA

Graphical network of the top 20 diseases related to Arteriovenous Malformation:



Diseases related to Arteriovenous Malformation

Symptoms & Phenotypes for Arteriovenous Malformation

UMLS symptoms related to Arteriovenous Malformation:


sleeplessness, vertigo/dizziness, chronic pain, tremor, syncope, seizures, sciatica, pain, headache, edema, chest pain, back pain, angina pectoris

MGI Mouse Phenotypes related to Arteriovenous Malformation:

43 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.29 BMPR2 ENG EFNB2 ACVRL1 PTEN ITGB8
2 growth/size/body region MP:0005378 10.24 BMPR2 ENG EFNB2 ACVRL1 MMP9 IL6
3 digestive/alimentary MP:0005381 10.18 ENG EFNB2 ACVRL1 PTEN ITGB8 MMP9
4 behavior/neurological MP:0005386 10.16 ACVRL1 EFNB2 BMPR2 MMP9 IL6 ENG
5 embryo MP:0005380 10.16 BMPR2 ENG EFNB2 ACVRL1 PTEN ITGB8
6 homeostasis/metabolism MP:0005376 10.16 EFNB2 ENG BMPR2 ACVRL1 MMP9 IL6
7 mortality/aging MP:0010768 10.14 BMPR2 ENG EFNB2 ACVRL1 MMP9 IL6
8 hematopoietic system MP:0005397 10.13 BMPR2 ENG ACVRL1 EFNB2 MMP9 IL6
9 immune system MP:0005387 10.09 EFNB2 BMPR2 MMP9 IL6 MMP3 EPHB4
10 muscle MP:0005369 10.07 BMPR2 ENG EFNB2 ACVRL1 PTEN EPHB4
11 nervous system MP:0003631 10.06 BMPR2 ENG EFNB2 ACVRL1 IL6 PTEN
12 craniofacial MP:0005382 10.01 ACVRL1 EFNB2 ENG ITGB8 RASA1 VEGFA
13 normal MP:0002873 9.8 ACVRL1 EFNB2 BMPR2 ENG ITGB8 VEGFA
14 renal/urinary system MP:0005367 9.76 BMPR2 EFNB2 ACVRL1 IL6 PTEN EPHB4
15 respiratory system MP:0005388 9.56 BMPR2 ENG EFNB2 ACVRL1 MMP9 IL6
16 skeleton MP:0005390 9.23 BMPR2 EFNB2 MMP9 IL6 MMP3 RASA1

Drugs & Therapeutics for Arteriovenous Malformation

Drugs for Arteriovenous Malformation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 153)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 5311068 56032 68602
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Bupivacaine Approved, Investigational Phase 4 38396-39-3, 2180-92-9 2474
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Ethanol Approved Phase 4 64-17-5 702
6
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 46507594 772
7
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 10909430 439542
8
Tranexamic Acid Approved Phase 4 1197-18-8 5526
9
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
10
Ropivacaine Approved Phase 4 84057-95-4 175805 71273
11
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
12
Ethiodized oil Approved, Investigational Phase 4 8008-53-5
13
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
14 Adrenergic Agents Phase 4
15 Adrenergic Agonists Phase 4
16 Adrenergic alpha-2 Receptor Agonists Phase 4
17 Adrenergic alpha-Agonists Phase 4
18 Analgesics Phase 4
19 Analgesics, Non-Narcotic Phase 4
20 Anesthetics Phase 4
21 Anesthetics, General Phase 4
22 Anesthetics, Intravenous Phase 4
23 Central Nervous System Depressants Phase 4
24 Hypnotics and Sedatives Phase 4
25 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
26 Peripheral Nervous System Agents Phase 4
27 Anesthetics, Local Phase 4
28 Anti-Arrhythmia Agents Phase 4
29 Diuretics, Potassium Sparing Phase 4
30 Sodium Channel Blockers Phase 4
31 Anticoagulants Phase 4,Phase 2
32 calcium heparin Phase 4,Phase 2
33 Calcium, Dietary Phase 4,Phase 2,Phase 1
34 Fibrinolytic Agents Phase 4,Phase 2
35 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
36 Antifibrinolytic Agents Phase 4
37 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
38 Anti-Infective Agents, Local Phase 4
39 Coagulants Phase 4
40 Hemostatics Phase 4
41 Vasodilator Agents Phase 4
42 Pharmaceutical Solutions Phase 4,Phase 2
43 Adjuvants, Anesthesia Phase 4
44 Analgesics, Opioid Phase 4
45 Narcotics Phase 4
46 Ferrosoferric Oxide Phase 4
47 Hematinics Phase 4
48 Parenteral Nutrition Solutions Phase 4
49 Anesthetics, Inhalation Phase 4
50 Platelet Aggregation Inhibitors Phase 4

Interventional clinical trials:

(show top 50) (show all 184)

# Name Status NCT ID Phase Drugs
1 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4 Propofol;Dexmedetomidine
2 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4 Bupivacaine plus lidocaine;Bupivacaine 30 ml
3 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
4 Effects of Heparin on Arteriovenous Fistula Patency Completed NCT02493504 Phase 4 Heparin
5 Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients Completed NCT02106962 Phase 4 Topical Tranexamic Acid 5% with bacitracin
6 The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas Completed NCT01685710 Phase 4 GTN patch;placebo comparator
7 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery Recruiting NCT02552459 Phase 4 Sufentanil;dexmedetomidine 1;dexmedetomidine 2;dexmedetomidine 3
8 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Recruiting NCT02478346 Phase 4 Fluorescein Sodium
9 Evaluation of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. Recruiting NCT02625389 Phase 4 Lipiodol® Ultra Fluid with surgical glues
10 Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Recruiting NCT02729740 Phase 4
11 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Recruiting NCT02997046 Phase 4
12 The Feasibility of Propofol TCI in Hemodialysis Patients Undergoing Arteriovenous Shunt Surgery Recruiting NCT03311581 Phase 4 Propofol
13 Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study Active, not recruiting NCT02378883 Phase 4
14 Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Not yet recruiting NCT02079818 Phase 4
15 Functional Magnetic Resonance Imagine(fMRI)Navigation in Intracranial Arteriovenous Malformation Surgery Unknown status NCT01758211 Phase 3
16 A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation Completed NCT01677624 Phase 3
17 A Randomized Trial of Unruptured Brain AVMs Completed NCT00389181 Phase 3
18 Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD Completed NCT02363972 Phase 3
19 Safety and Efficacy Study of the Venous Window Needle Guide to Access Arteriovenous (AV)Fistulae Completed NCT01471041 Phase 2, Phase 3
20 Feasibility Study of Phase-contrast MRI for Flow in the External Carotid Branches Arteries Recruiting NCT02829190 Phase 3
21 BABH Study: Efficacy and Safety of Bevacizumab on Severe Bleedings Associated With Hemorrhagic Hereditary Telangiectasia (HHT). Recruiting NCT03227263 Phase 3 Bevacizumab;sodium chloride 0.9%
22 Paclitaxel-coated Balloon Angioplasty Versus Standard Angioplasty for the Treatment of Stenosis of Arteriovenous Fistula Recruiting NCT02753998 Phase 3
23 Primary Patency in Post-angioplasty Dysfunctional Arteriovenous Fistula in Renal Dialysis: Paclitaxel-releasing PTA Balloon Catheter vs PTA Balloon Recruiting NCT02565953 Phase 3
24 Trial to Evaluate the Sirolimus-Eluting Collagen Implant on AV Fistula Outcomes Recruiting NCT02513303 Phase 3 Sirolimus
25 A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2) Recruiting NCT02414841 Phase 3 vonapanitase;Placebo
26 Preoperative Arteriovenous Fistula Simulation Study (ShuntSimulationStudy) Recruiting NCT02453412 Phase 2, Phase 3
27 Study Comparing Lutonix AV Drug Coated Balloon vs Standard Balloon for Treatment of Dysfunctional AV Fistulae Active, not recruiting NCT02440022 Phase 3
28 A Study of PRT-201 Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-1) Active, not recruiting NCT02110901 Phase 3 PRT-201;Placebo
29 Arteriovenous Fistula: Conventional Angioplasty vs Drug Eluting Balloon-assisted Maturation Intervention Clinical Trial Not yet recruiting NCT03068845 Phase 3
30 Zero Ischemia Laparoscopic Partial Nephrectomy Withdrawn NCT02634385 Phase 2, Phase 3
31 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2 bevacuzimab spray
32 Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs) Completed NCT00857662 Phase 2
33 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2 Thalidomide
34 Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia Completed NCT01485224 Phase 2 Thalidomide
35 An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Creation of an Arteriovenous Fistula to Facilitate Hemodialysis Access Completed NCT01806545 Phase 2
36 A Phase 1-2 Study of PRT-201 Administered in Chronic Kidney Disease (CKD) Patients Completed NCT00679991 Phase 1, Phase 2 PRT-201;PRT-201
37 A Study of PRT-201 Administered Immediately After Arteriovenous Fistula Creation in Patients With Chronic Kidney Disease Completed NCT01305824 Phase 2 PRT-201;Placebo;PRT-201
38 Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Recruiting NCT02042326 Phase 2 Sirolimus
39 Proton Radiotherapy for Primary Central Nervous System Tumours in Adults Recruiting NCT02797366 Phase 2
40 A Safety and Efficacy Trial of Circumferential Anal Canal Radiofrequency Ablation for High-Grade Anal Intraepithelial Neoplasia Using the BARRX™ Anorectal Wand Recruiting NCT03302858 Phase 2
41 Delivery of Inhibitors of Lysyl Oxidase (LysoLox) on Serial Angioplasty and Time to Restenosis Recruiting NCT03106948 Phase 2 Placebo;Ascorbic Acid;Cuprimine Oral Product
42 Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis Recruiting NCT02335099 Phase 1, Phase 2 ticagrelor;Placebo
43 Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula Recruiting NCT01863914 Phase 2 Rosuvastatin
44 High-intensity Atorvastatin for Arteriovenous Fistula Failure (HAFF): A Feasibility Pilot Study Not yet recruiting NCT03188978 Phase 1, Phase 2 Atorvastatin 40mg
45 Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis Terminated NCT01382888 Phase 2 Heparin 2,400 IU /ml Cutaneous Spray;Placebo Cutaneous Spray
46 Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms Completed NCT00243893 Phase 1 minocycline;doxycycline
47 Influence of MMP on Brain AVM Hemorrhage Completed NCT00783523 Phase 1 Doxycycline or Placebo
48 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1 Marimastat
49 Bevacizumab Therapy for Brain Arteriovenous Malformation Recruiting NCT02314377 Phase 1 Bevacizumab
50 Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB Recruiting NCT02496013 Phase 1 68Ga-NEB

Search NIH Clinical Center for Arteriovenous Malformation

Genetic Tests for Arteriovenous Malformation

Genetic tests related to Arteriovenous Malformation:

# Genetic test Affiliating Genes
1 Arteriovenous Malformation 28

Anatomical Context for Arteriovenous Malformation

MalaCards organs/tissues related to Arteriovenous Malformation:

38
Brain, Spinal Cord, Heart, Testes, Endothelial, Kidney, Bone

Publications for Arteriovenous Malformation

Articles related to Arteriovenous Malformation:

(show top 50) (show all 1302)
# Title Authors Year
1
Management of pregnancy complicated with intracranial arteriovenous malformation. ( 29369471 )
2018
2
Surgical Treatment vs Nonsurgical Treatment for Brain Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia: A Retrospective Multicenter Consortium Study. ( 29281110 )
2018
3
External Ear Arteriovenous Malformation. ( 29342048 )
2018
4
Eyelid arteriovenous malformation treated with pre-surgical embolization: A case report. ( 29359613 )
2018
5
Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. ( 29303444 )
2018
6
Extensive uterine arteriovenous malformation with hemodynamic instability: Embolization for whole myometrium affection. ( 29395294 )
2018
7
Combined transarterial and transvenous embolization of a ruptured utero-ovarian arteriovenous malformation with ethylene vinyl alcohol copolymer (Onyx<sup>Ar</sup>). ( 29433830 )
2018
8
Somatic Activating KRAS Mutations in Arteriovenous Malformations of the Brain. ( 29298116 )
2018
9
Combined Endovascular and Microsurgical Treatment of a Premotor Arteriovenous Malformation: 2-Dimensional Operative Video. ( 29346607 )
2018
10
Dieulafoy's disease with mediastinal arteriovenous malformation. ( 29353256 )
2018
11
A tale of two cases of pulmonary arteriovenous malformation: How they fared after cardiac transplantation. ( 29277952 )
2018
12
Pseudoaneurysm formation and rupture after stereotactic radiotherapy for cerebral arteriovenous malformation: a case report and review of literature. ( 29433331 )
2018
13
RASA1 mutation in a family with capillary malformation-arteriovenous malformation syndrome: A discussion of the differential diagnosis. ( 29120072 )
2018
14
Varicocele due to renal arteriovenous malformation mimicking a renal tumor: a case report. ( 29304872 )
2018
15
First use of Micro Vascular Plugs in Australia: Endovascular treatment of pulmonary arteriovenous malformation. ( 28990732 )
2018
16
Conus medullaris arteriovenous malformation presenting with acute dysphagia and intractable hiccups. ( 29305117 )
2018
17
Somatic second hit mutation of RASA1 in vascular endothelial cells in capillary malformation-arteriovenous malformation. ( 29024832 )
2018
18
Development of three-dimensional brain arteriovenous malformation model for patient communication and young neurosurgeon education. ( 29334259 )
2018
19
Embolisation for pulmonary arteriovenous malformation. ( 29298459 )
2018
20
Early Hemodynamic Response Assessment of Stereotactic Radiosurgery for a Cerebral Arteriovenous Malformation Using 4D Flow MRI. ( 29371257 )
2018
21
Utility of second-generation single-energy metal artifact reduction in helical lung computed tomography for patients with pulmonary arteriovenous malformation after coil embolization. ( 29429141 )
2018
22
Predictors of intracranial hemorrhage volume and distribution in brain arteriovenous malformation. ( 29343148 )
2018
23
Role of time-resolved-CTA in intracranial arteriovenous malformation evaluation at 128-slice CT in comparison with digital subtraction angiography. ( 29366361 )
2018
24
Usefulness and Stability of Intraoperative Digital Subtraction Angiography Using the Transradial Route in Arteriovenous Malformation Surgery. ( 29309977 )
2018
25
Trans-venous embolization of a basal ganglia ruptured arteriovenous malformation with open surgical arterial control: a hybrid technique. ( 29410371 )
2018
26
Pulmonary Arteriovenous Malformation Causing Systemic Hypoxemia in Early Infancy. ( 28373920 )
2017
27
Unilateral moyamoya disease with co-existing arteriovenous malformation. ( 28084278 )
2017
28
Clinical outcomes and radiosurgical considerations for pediatric arteriovenous malformation: influence of clinical features on obliteration rate. ( 28871374 )
2017
29
Pulmonary arteriovenous malformations complicated by splenic infarction and abscess. ( 28736615 )
2017
30
DNA Methylation of the PDGFD Gene Promoter Increases the Risk for Intracranial Aneurysms and Brain Arteriovenous Malformations. ( 28346846 )
2017
31
Proteus Syndrome with Arteriovenous Malformation. ( 28401074 )
2017
32
Ascertaining the Value of Noninvasive Measures Obtained Using Color Duplex Ultrasound and Central Aortic Pressure Monitoring During the Management of Cerebral Arteriovenous Malformation Resection: Protocol for a Prospective, Case Control Pilot Study. ( 28860105 )
2017
33
Arteriovenous Malformations of the Brain. ( 28489992 )
2017
34
Meticulous observations essential before and after coil embolization of pulmonary arteriovenous malformation; lessons learned from two case. ( 28761454 )
2017
35
Transarterial Embolization and Transmucosal Sclerotherapy That Led to Successful Deliveries in a Patient With Symptomatic Arteriovenous Malformation of the Tongue. ( 28857995 )
2017
36
Brain infarction after embolization of a pulmonary arteriovenous malformation with metallic coils. ( 28377085 )
2017
37
Giant Chest Wall Arteriovenous Malformation: A Case Report and Literature Review. ( 28890056 )
2017
38
Pial Arteriovenous Fistula and Capillary Malformation-Arteriovenous Malformation Associated with RASA1 Mutation: 2 Pediatric Cases with Successful Surgical Management. ( 28558378 )
2017
39
Combined Endovascular and Microsurgical Management of an Unruptured Grade 2 Parietal Arteriovenous Malformation: 2-Dimensional Operative Video. ( 29300931 )
2017
40
Orthodeoxia without Platypnea in Hereditary Hemorrhagic Telangiectasia in the Presence of a Cerebral Abscess and Multiple Pulmonary Arteriovenous Malformations: Unusual Complications and Transcatheter Endovascular Treatment. ( 29158938 )
2017
41
An unusual combination of patent foramen ovale with pulmonary arteriovenous malformation in a young patient with stroke. ( 28681775 )
2017
42
Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation. ( 28190454 )
2017
43
Comprehensive Treatment of Primary Orbital Arteriovenous Malformation. ( 28841594 )
2017
44
Successful presurgical endovascular management of venous sinus thrombosis associated with high-grade cerebral arteriovenous malformation: A case report. ( 28893127 )
2017
45
Arteriovenous Malformations of the Brain. ( 28767347 )
2017
46
Pulmonary Arteriovenous Malformation Detected by Three-dimensional Computed Tomographic Angiography. ( 28400192 )
2017
47
EPHB4 Mutation Implicated in Capillary Malformation-Arteriovenous Malformation Syndrome: A Case Report. ( 28730721 )
2017
48
Germline Loss-of-Function Mutations in EPHB4 Cause a Second Form of Capillary Malformation-Arteriovenous Malformation (CM-AVM2) Deregulating RAS-MAPK Signaling. ( 28687708 )
2017
49
Hepatopulmonary syndrome with large pulmonary arteriovenous malformations: CT findings with emphasis on its association with a mosaic pattern of the lung parenchyma. ( 28480722 )
2017
50
Combined Transsylvian Transventricular Approach to a Hippocampal Arteriovenous Malformation: 3-Dimensional Operative Video. ( 28931259 )
2017

Variations for Arteriovenous Malformation

Expression for Arteriovenous Malformation

Search GEO for disease gene expression data for Arteriovenous Malformation.

Pathways for Arteriovenous Malformation

Pathways related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 EPHB4 IL6 ITGB8 MMP3 MMP9 RASA1
2
Show member pathways
13.44 ACVRL1 BMPR2 EPHB4 IL6 ITGB8 PTEN
3
Show member pathways
13.15 ACVRL1 BMPR2 EPHB4 IL6 ITGB8 PTEN
4
Show member pathways
13.14 ITGB8 MMP3 MMP9 PTEN VEGFA
5
Show member pathways
12.77 IL6 MMP3 MMP9 PTEN VEGFA
6
Show member pathways
12.52 ITGB8 MMP3 MMP9 PLOD2
7
Show member pathways
12.28 IL6 MMP9 PTEN VEGFA
8 12.21 BMPR2 MMP9 PTEN VEGFA
9
Show member pathways
12.2 EFNB2 EPHB4 MMP9 RASA1 VEGFA
10 11.97 IL6 MMP9 VEGFA
11 11.91 BMPR2 PTEN VEGFA
12 11.87 BMPR2 EFNB2 EPHB4 RASA1
13 11.86 BMPR2 MMP9 VEGFA
14 11.77 EFNB2 IL6 MMP9
15 11.69 IL6 MMP3 MMP9
16 11.53 IL6 MMP3 VEGFA
17 11.51 IL6 MMP3 MMP9 VEGFA
18 11.2 EFNB2 ENG MMP3 MMP9
19
Show member pathways
11.02 ACVRL1 BMPR2
20 11.02 EFNB2 EPHB4
21 10.94 MMP9 VEGFA
22
Show member pathways
10.72 IL6 MMP3 MMP9 VEGFA

GO Terms for Arteriovenous Malformation

Cellular components related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 ACVRL1 BMPR2 ENG ITGB8 VEGFA

Biological processes related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.92 IL6 MMP9 PTEN RASA1 VEGFA
2 response to hypoxia GO:0001666 9.84 ACVRL1 PLOD2 VEGFA
3 positive regulation of protein phosphorylation GO:0001934 9.83 ENG MMP9 VEGFA
4 positive regulation of angiogenesis GO:0045766 9.82 ACVRL1 ENG VEGFA
5 positive regulation of gene expression GO:0010628 9.8 ENG IL6 ITGB8 PTEN VEGFA
6 negative regulation of cell migration GO:0030336 9.79 ACVRL1 ENG PTEN
7 negative regulation of gene expression GO:0010629 9.78 ACVRL1 ENG ITGB8 VEGFA
8 BMP signaling pathway GO:0030509 9.77 ACVRL1 BMPR2 ENG
9 positive regulation of endothelial cell proliferation GO:0001938 9.73 ACVRL1 BMPR2 VEGFA
10 vasculogenesis GO:0001570 9.67 ENG RASA1 VEGFA
11 outflow tract septum morphogenesis GO:0003148 9.66 BMPR2 ENG
12 artery morphogenesis GO:0048844 9.65 ENG VEGFA
13 cardiac muscle tissue development GO:0048738 9.65 BMPR2 PTEN
14 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.64 ACVRL1 BMPR2
15 macrophage differentiation GO:0030225 9.63 MMP9 VEGFA
16 activin receptor signaling pathway GO:0032924 9.63 ACVRL1 BMPR2
17 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.63 ACVRL1 BMPR2 ENG
18 endocardial cushion morphogenesis GO:0003203 9.62 ACVRL1 ENG
19 negative regulation of focal adhesion assembly GO:0051895 9.61 ACVRL1 PTEN
20 negative regulation of DNA biosynthetic process GO:2000279 9.61 ACVRL1 BMPR2
21 lymphangiogenesis GO:0001946 9.6 ACVRL1 BMPR2
22 retina vasculature development in camera-type eye GO:0061298 9.58 ACVRL1 BMPR2
23 artery development GO:0060840 9.58 ACVRL1 BMPR2
24 dorsal aorta morphogenesis GO:0035912 9.57 ACVRL1 ENG
25 venous blood vessel morphogenesis GO:0048845 9.55 EFNB2 ENG
26 positive regulation of axon extension involved in axon guidance GO:0048842 9.54 BMPR2 VEGFA
27 lymphatic endothelial cell differentiation GO:0060836 9.51 ACVRL1 BMPR2
28 positive regulation of BMP signaling pathway GO:0030513 9.5 ACVRL1 BMPR2 ENG
29 ephrin receptor signaling pathway GO:0048013 9.46 EFNB2 EPHB4 MMP9 RASA1
30 venous blood vessel development GO:0060841 9.43 ACVRL1 BMPR2
31 blood vessel morphogenesis GO:0048514 9.43 ACVRL1 EFNB2 RASA1
32 endocardial cushion to mesenchymal transition GO:0090500 9.37 ACVRL1 ENG
33 angiogenesis GO:0001525 9.35 ACVRL1 ENG EPHB4 PTEN VEGFA
34 cell migration involved in sprouting angiogenesis GO:0002042 8.8 EFNB2 EPHB4 VEGFA

Molecular functions related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.4 ACVRL1 ENG
2 platelet-derived growth factor receptor binding GO:0005161 9.37 PTEN VEGFA
3 signal transducer, downstream of receptor, with serine/threonine kinase activity GO:0004702 9.32 ACVRL1 BMPR2
4 activin binding GO:0048185 9.26 ACVRL1 ENG
5 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.16 ACVRL1 BMPR2
6 BMP binding GO:0036122 8.96 BMPR2 ENG
7 BMP receptor activity GO:0098821 8.62 ACVRL1 BMPR2

Sources for Arteriovenous Malformation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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