MCID: ART005
MIFTS: 62

Arteriovenous Malformation malady

Summaries for Arteriovenous Malformation

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
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MedlinePlus:34 Arteriovenous malformations (avms) are defects in your vascular system. the vascular system includes arteries, veins, and capillaries. arteries carry blood away from the heart to other organs; veins carry blood back to the heart. capillaries connect the arteries and veins. an avm is a snarled tangle of arteries and veins. they are connected to each other, with no capillaries. that interferes with the blood circulation in an organ. avms can happen anywhere, but they are more common in the brain or spinal cord. most people with brain or spinal cord avms have few, if any, major symptoms. sometimes they can cause seizures or headaches. avms are rare. the cause is not known, but they seem to develop during pregnancy or soon after birth. doctors use imaging tests to detect them. medicines can help with the symptoms from avms. the greatest danger is hemorrhage. treatment for avms can include surgery or focused radiation therapy. because surgery can be risky, you and your doctor need to make a decision carefully. nih: national institute of neurological disorders and stroke

MalaCards: Arteriovenous Malformation, also known as arteriovenous malformations, is related to hereditary hemorrhagic telangiectasia and intracranial aneurysm. An important gene associated with Arteriovenous Malformation is RASA1 (RAS p21 protein activator (GTPase activating protein) 1), and among its related pathways are p70S6K Signaling and HIF-2-alpha transcription factor network. The compounds zd6474 and axitinib have been mentioned in the context of this disorder. Affiliated tissues include whole blood, brain and cerebellum, and related mouse phenotypes are embryogenesis and nervous system.

Wikipedia:64 Arteriovenous malformation or AVM is an abnormal connection between arteries and veins, bypassing the... more...

Aliases & Classifications for Arteriovenous Malformation

Sources:
8Disease Ontology, 20GeneTests, 44NINDS, 10DISEASES, 61UMLS, 45Novoseek, 34MedlinePlus, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

arteriovenous malformation 8 20 44 10 61
arteriovenous malformations 45 34
arteriovenous hemangioma 8
racemose hemangioma 8
racemose aneurysm 8
cirsoid aneurysm 8
racemose angioma 8


External Ids:

Disease Ontology8 DOID:11294
NCIt40 C4297

Related Diseases for Arteriovenous Malformation

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Arteriovenous Malformation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 292)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary hemorrhagic telangiectasia31.3TGFBR1, ENG, ACVRL1
2intracranial aneurysm30.6ENG
3klippel-trenaunay syndrome30.6RASA1, FLT4
4adenoma30.4FLT4, FLT1, VEGFB, SLC2A1, ENG, SMAD4
5intracranial hemorrhage in brain cerebrovascular malformations30.3FLT1, KDR, ACVRL1, TEK, ENG
6cerebral cavernous malformation30.3PECAM1, KDR
7astrocytoma30.2ENG, TEK, SLC2A1, KDR, HIF1A, FLT1
8angiodysplasia30.2ACVRL1, ENG
9hemangioendothelioma30.0FLT4
10hepatopulmonary syndrome30.0ALB, HMOX1
11gastrointestinal stromal tumor30.0KDR
12vasculitis30.0ALB
13pyogenic granuloma30.0FLT4, SLC2A1, TEK, PECAM1
14primary pulmonary hypertension30.0FLT1, HIF1A, ACVRL1, TEK
15cadasil30.0NGB, MMP12, SLC2A1, ENG, PECAM1
16telangiectasis30.0ENG, ACVRL1
17pulmonary arteriovenous malformation11.2
18intracranial arteriovenous malformation11.0
19capillary malformation-arteriovenous malformation syndrome10.7
20mandibular arteriovenous malformation10.6
21weber syndrome10.6
22cerebral aneurysms10.5
23cavernous malformation10.4
24trigeminal neuralgia10.4
25hemorrhage, intracerebral10.4
26obstructive hydrocephalus10.3
27cobb syndrome10.3
28moyamoya disease10.3
29brain edema10.3
30n syndrome10.3
31maxillary arteriovenous malformation10.3
32duodenal ulcer10.2
33exophthalmos10.2
34siderosis10.2
35brain disease10.2
36vein of galen aneurysm10.2
37sturge-weber syndrome10.2
38lipomyelomeningocele10.2
39heterotaxy10.2
40headache10.2
41stroke, hemorrhagic10.2
42segmental outgrowth - lipomatosis - arteriovenous malformation - epidermal nevus10.2
43superficial siderosis10.2
44dural sinus malformation10.2
45stroke, ischemic10.1
46pulmonary tuberculosis10.1
47syringomyelia10.1
48bannayan-riley-ruvalcaba syndrome10.1
49cauda equina syndrome10.1
50pleomorphic xanthoastrocytoma10.1

Graphical network of the top 20 diseases related to Arteriovenous Malformation:



Diseases related to arteriovenous malformation

Clinical Features for Arteriovenous Malformation

Drugs & Therapeutics for Arteriovenous Malformation

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arteriovenous Malformation

Drug clinical trials:

Search ClinicalTrials for Arteriovenous Malformation

Search NIH Clinical Center for Arteriovenous Malformation

Search CenterWatch for Arteriovenous Malformation

Genetic Tests for Arteriovenous Malformation

Sources:
20GeneTests
See all sources

Genetic tests related to Arteriovenous Malformation:

id Genetic test Affiliating Genes
1 Arteriovenous Malformations20

Anatomical Context for Arteriovenous Malformation

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Arteriovenous Malformation:

33
Whole blood, Brain, Cerebellum, Spinal cord, Heart, Small intestine, Colon, Kidney, Liver, Lung, Pancreas, Thyroid, Adrenal gland, Breast, Uterus, Placenta, T cells, Endothelial, Fetal brain, Temporal lobe, Occipital lobe, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pineal, Pituitary, Uterus corpus

Animal Models for Arteriovenous Malformation or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Arteriovenous Malformation

Sources:
51PubMed
See all sources

Articles related to Arteriovenous Malformation:

(show top 50)    (show all 993)
idTitleAuthorsYear
1
Brainstem arteriovenous malformation presenting with dyspraxic handwriting in a young girl. (23911278)
2013
2
Editorial: arteriovenous malformation. (23530832)
2013
3
CobraPLA-guided tracheal intubation for airway rescue in a child with large orofacial arteriovenous malformation. (23968664)
2013
4
Cerebral arteriovenous malformation presenting late in life. (23466020)
2013
5
The origin of idiopathic renal arteriovenous malformation with giant twin aneurysms. (23249874)
2013
6
Prevalence of pulmonary arteriovenous malformations in children versus adults with hereditary hemorrhagic telangiectasia. (23522378)
2013
7
The coexistence of pleomorphic xanthoastrocytoma and arteriovenous malformation. A case report. (24114645)
2013
8
Uses and limitations of indocyanine green videoangiography for flow analysis in arteriovenous malformation surgery. (23277126)
2013
9
Hydrocephalus after arteriovenous malformation rupture. (23634915)
2013
10
Glioblastoma mimicking an arteriovenous malformation. (24137154)
2013
11
Capillary malformation-arteriovenous malformation: a clinical review of 45 patients. (24168113)
2013
12
Doppler sonographic evaluation of arteriovenous shunt flow in a fetus with dural sinus malformation. (23551661)
2013
13
Temporary alopecia after embolization of an arteriovenous malformation. (23031381)
2012
14
Contralateral decubitus positioning enhances computed tomographic angiographic evaluation of pulmonary vasculature in a patient with a pulmonary arteriovenous malformation. (22437510)
2012
15
The rs9509 polymorphism of MMP-9 is associated with risk of hemorrhage in brain arteriovenous malformations. (22796276)
2012
16
Brain arteriovenous malformations associated with hereditary hemorrhagic telangiectasia: gene-phenotype correlations. (22991266)
2012
17
An invasive mole presenting with large arteriovenous malformation. (23372297)
2012
18
Persistent hiccup after surgical resection of a brainstem arteriovenous malformation: a case successfully treated with gabapentin during rehabilitation. Case report. (22083264)
2012
19
Ruptured aneurysm of intercostal arteriovenous malformation associated with neurofibromatosis type 1: a case report. (20711836)
2011
20
Occlusion of an intraosseous arteriovenous malformation with percutaneous injection of polymethylmethacrylate. (20945068)
2011
21
Transcatheter embolization of uterine arteriovenous malformation: report of 2 cases and review of literature. (22024270)
2011
22
Hemostasis and obliteration of mandibular arteriovenous malformation through direct hydroxyapatite cement injection into the molar cavity. (21990799)
2011
23
Arteriovenous malformation: a rare manifestation of PHACE syndrome. (21504447)
2011
24
Three-dimensional magnetic resonance imaging based on time-of-flight magnetic resonance angiography for superficial cerebral arteriovenous malformation--technical note. (21358166)
2011
25
Microsurgical glue embolectomy of the middle cerebral artery following embolization of a maxillofacial arteriovenous malformation. (21985743)
2011
26
Arteriovenous malformation of the stomach: a rare cause of upper gastrointestinal bleeding. (22106696)
2011
27
Reversible hemianopsia caused by mechanical compression of the visual pathway by the dilated draining vein of an arteriovenous malformation--case report. (20587972)
2010
28
Treatment of giant cerebral arteriovenous malformation: hypofractionated stereotactic radiation as the first stage. (20948400)
2010
29
Arteriovenous Malformation in a Child with Extensive Involvement of the Mandible and Maxilla. (20671863)
2010
30
Brain edema associated with unruptured brain arteriovenous malformations. (19219601)
2009
31
Spinal root arteriovenous malformations and same-segment cord cavernous malformation in familial cerebral cavernous malformation. Case report. (18928219)
2008
32
Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity. (17392703)
2007
33
Symptomatic superficial siderosis due to an intracranial arteriovenous malformation. (17803045)
2007
34
Transpleural ultrasound diagnosis of a pulmonary arteriovenous malformation. (15238412)
2004
35
Complete obliteration of intracranial arteriovenous malformation with endovascular cyanoacrylate embolization: initial success and rate of permanent cure. (15313697)
2004
36
Telangiectatic pulmonary arteriovenous malformation. (12700489)
2003
37
Duodenal ulcer and pancreatitis associated with pancreatic arteriovenous malformation. (11984154)
2002
38
Leber's hereditary optic neuropathy with intracranial arteriovenous malformation: a case report. (12161905)
2002
39
Intramedullary hemorrhage caused by arteriovenous malformation: a case of mixed lateral and medial medullary syndrome. (17903797)
2001
40
Abnormal pattern of Tie-2 and vascular endothelial growth factor receptor expression in human cerebral arteriovenous malformations. (11014431)
2000
41
Diagnosis, management, and pathophysiology of post-Fontan hypoxaemia secondary to Glenn shunt related pulmonary arteriovenous malformation. (10490576)
1999
42
Headaches and papilledema secondary to dural arteriovenous malformation. (11398307)
1998
43
Reversal of pulmonary arteriovenous malformation after diversion of anomalous hepatic drainage. (9527235)
1998
44
Diffuse pulmonary arteriovenous malformation in a child with polysplenia syndrome. (8597833)
1995
45
Arteriovenous malformation in meningothelial meningioma: case report. (1870670)
1991
46
Association of a ganglioneuroma with an arteriovenous malformation: case report. (3309712)
1987
47
Intracranial arteriovenous malformation and migraine. (6498934)
1984
48
Pulmonary arteriovenous malformation: an uncommon cause for cyanosis in the newborn. (6646888)
1983
49
Orthocyanosis: a sign of pulmonary arteriovenous malformation. (7170687)
1982
50
Method for detecting intracranial arteriovenous malformation with an ultrasonic transducer using the Doppler phenomenon. (6020021)
1967

Genetic Variations for Arteriovenous Malformation

Expression for genes affiliated with Arteriovenous Malformation

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arteriovenous Malformation

Search GEO for disease gene expression data for Arteriovenous Malformation.

Pathways for genes affiliated with Arteriovenous Malformation

Sources:
52QIAGEN, 38NCBI BioSystems Database, 56SinoBiological, 4Cell Signaling Technology, 50PharmGKB, 60Tocris Bioscience, 54Reactome, 53R&D Systems, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TIMP4
210.4SLC2A1, FLT1
310.4ACVRL1, ENG, TGFBR1
410.4TGFBR1, SMAD4, ENG
510.4ENG, SMAD4, TGFBR1
610.4ACVRL1, SMAD4, TGFBR1
7
Hide members
10.3FLT4, FLT1, KDR
810.3KDR, VEGFB, FLT4
9
Hide members
10.3VEGFB, PECAM1, ALB
1010.3TGFBR1, SMAD4, ENG, ACVRL1
1110.3ACVRL1, ENG, SMAD4, TGFBR1
1210.3VEGFB, HIF1A, SLC2A1
13
Hide members
10.3FLT4, FLT1, KDR, TGFBR1
1410.3FLT4, FLT1, KDR, TEK
15
Hide members
10.3TEK, KDR, FLT1, FLT4
1610.3FLT1, KDR, ACVRL1, SMAD4
1710.3FLT1, HIF1A, KDR, TEK
18
Hide members
10.3KDR, VEGFB, FLT1, FLT4
19
Hide members
10.3KDR, VEGFB, FLT1, FLT4
20
Hide members
10.3FLT4, FLT1, VEGFB, KDR
21
Hide members
10.3FLT4, FLT1, VEGFB, KDR
22
Hide members
10.3KDR, VEGFB, FLT1, FLT4
2310.3HIF1A, HMOX1, SLC2A1, ENG, SMAD4
2410.2TEK, KDR, VEGFB, FLT1, FLT4
2510.2FLT1, HIF1A, HMOX1, SLC2A1, TEK
2610.2VEGFB, HIF1A, SLC2A1, SMAD4, TGFBR1
27
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, TEK
28
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR
29
Hide members
10.2FLT4, FLT1, VEGFB, KDR, ACVRL1, TEK
30
Hide members
10.2FLT4, FLT1, VEGFB, HIF1A, RASA1, KDR
31
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR, TGFBR1
32
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR, TGFBR1
33
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR, TEK
34
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, TEK
35
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, TEK
36
Hide members
10.1FLT4, FLT1, VEGFB, HIF1A, RASA1, KDR
37
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, ACVRL1
38
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, SLC2A1
39
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, MMP12, RASA1
4010.0TGFBR1, FLT4, FLT1, VEGFB, HIF1A, HMOX1
41
Hide members
10.0TIMP4, FLT4, FLT1, VEGFB, HIF1A, RASA1

Compounds for genes affiliated with Arteriovenous Malformation

Sources:
45Novoseek, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 29IUPHAR, 24HMDB, 2BitterDB
See all sources

Compounds related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1zd64744510.8KDR, FLT1, FLT4
2axitinib45 60 1112.7KDR, FLT1, FLT4
3su54164510.7FLT4, FLT1, HIF1A, KDR
4Regorafenib1110.7FLT4, FLT1, KDR, TEK
5Pazopanib1110.7KDR, FLT1, FLT4
6sunitinib45 50 1112.7KDR, HIF1A, FLT1, FLT4
7cobalt chloride4510.7SLC2A1, HMOX1, HIF1A
8heparin45 29 11 2413.7FLT1, SLC2A1, PECAM1, TGFBR1
9ki 87516010.7FLT1, FLT4
10zm 323881 hydrochloride6010.7FLT1, FLT4
11zm 306416 hydrochloride6010.7FLT1, FLT4
12tgf beta14510.7FLT1, KDR, ACVRL1, ENG, SMAD4, TGFBR1
13dmh46010.7FLT4, FLT1
14vegfe2910.7FLT4, KDR
15agar4510.6HIF1A, KDR, SLC2A1, ENG, PECAM1, SMAD4
16matrigel4510.6FLT4, FLT1, HIF1A, KDR, TEK, PECAM1
17vegfa2910.6FLT1, KDR
18dexamethasone45 50 29 1113.6HIF1A, MMP12, KDR, SLC2A1, ENG, TGFBR1
19vegfc2910.6FLT4, KDR
20ly2940024510.6FLT4, HIF1A, HMOX1, KDR, SLC2A1, TGFBR1
21adp45 29 2412.6FLT4, ACVRL1, TEK, PECAM1, TGFBR1
22ribonucleic acid4510.6FLT1, SLC2A1, TEK, PECAM1, TGFBR1
23rapamycin4510.6FLT4, FLT1, HIF1A, KDR, SLC2A1, PECAM1
24glucose4510.6FLT1, HIF1A, NGB, SLC2A1, SMAD4, TGFBR1
25doxorubicin45 50 1112.6FLT1, HIF1A, ABCC5, HMOX1, KDR, ENG
26genistein45 29 60 2 11 2415.6FLT1, HIF1A, MMP12, KDR, SLC2A1, TGFBR1
27lactate4510.6HIF1A, HMOX1, KDR, SLC2A1, SMAD4, ALB
28ascorbic acid45 2411.6HIF1A, HMOX1, SLC2A1, ENG, ALB
29thymidine45 2411.6FLT1, HIF1A, KDR, TEK, PECAM1, SMAD4
30cisplatin45 50 60 1113.5FLT1, HIF1A, ABCC5, HMOX1, KDR, SLC2A1
31azd 21714510.5KDR, FLT4
32threonine4510.5HIF1A, ACVRL1, TEK, ENG, PECAM1, SMAD4
33serine4510.5FLT1, MMP12, RASA1, SLC2A1, ACVRL1, TEK
34phosphatidylinositol4510.5FLT1, HIF1A, MMP12, RASA1, KDR, SLC2A1
35p0024510.5FLT1, TEK, ENG, PECAM1
36paraffin4510.5FLT4, FLT1, HIF1A, KDR, SLC2A1, TEK
37alanine4510.5HIF1A, RASA1, HMOX1, SLC2A1, SMAD4, ALB
38nitric oxide45 11 2412.4FLT1, HIF1A, NGB, MMP12, HMOX1, KDR
39cysteine4510.4ANGPTL4, HIF1A, NGB, HMOX1, KDR, SLC2A1
40mg 13245 6011.4HIF1A, HMOX1, KDR, SMAD4
41oxygen45 2411.4FLT4, FLT1, VEGFB, HIF1A, NGB, MMP12
42lipid4510.4FLT1, ANGPTL4, NGB, MMP12, ENG, PECAM1
43wogonin4510.4KDR, FLT1
44dihydrotestosterone45 29 11 2413.4HIF1A, ENG, SMAD4, TGFBR1
45h2o24510.4FLT1, HIF1A, NGB, HMOX1, KDR, PECAM1
46tyrosine4510.3MMP12, HIF1A, VEGFB, FLT1, FLT4, RASA1
47rotenone4510.3SLC2A1, HMOX1, HIF1A
48vegf4510.3TGFBR1, FLT4, FLT1, VEGFB, HIF1A, MMP12
49oligonucleotide4510.1HIF1A, MMP12, ACVRL1, ENG, SMAD4, TGFBR1
50prostacyclin4510.0FLT1, HMOX1, KDR, PECAM1

GO Terms for genes affiliated with Arteriovenous Malformation

Sources:
16Gene Ontology
See all sources

Cellular components related to Arteriovenous Malformation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.2FLT1, ABCC5, KDR, ACVRL1, TEK, FLT4
2transforming growth factor beta receptor homodimeric complexGO:07002210.1TGFBR1, ENG
3extracellular spaceGO:00561510.1ALB, TIMP4, FLT1, VEGFB, ANGPTL4, HMOX1
4extracellular regionGO:00557610.0TIMP4, FLT4, VEGFB, ANGPTL4, MMP12, KDR

Biological processes related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein phosphorylationGO:00193410.8KDR, FLT4
2cellular response to vascular endothelial growth factor stimulusGO:03592410.7FLT4, FLT1, KDR
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086210.7ACVRL1, ENG, SMAD4, TGFBR1
4positive regulation of BMP signaling pathwayGO:03051310.7SMAD4, ENG, ACVRL1
5sprouting angiogenesisGO:00204010.7TEK, FLT1, FLT4
6negative regulation of endothelial cell proliferationGO:00193710.7TGFBR1, ENG, ACVRL1
7positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.7HIF1A, VEGFB, FLT1
8peptidyl-tyrosine phosphorylationGO:01810810.7TEK, KDR, FLT1, FLT4
9regulation of transforming growth factor beta2 productionGO:03290910.7SMAD4, HIF1A
10transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.7FLT4, FLT1, KDR, TEK
11positive regulation of endothelial cell migrationGO:01059510.7FLT4, KDR, TEK
12vascular endothelial growth factor receptor signaling pathwayGO:04801010.7KDR, VEGFB, FLT1, FLT4
13regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.7HIF1A, HMOX1
14transforming growth factor beta receptor signaling pathwayGO:00717910.7ACVRL1, ENG, SMAD4, TGFBR1
15positive regulation of ERK1 and ERK2 cascadeGO:07037410.7FLT4, VEGFB, KDR, TEK
16negative regulation of neuron apoptotic processGO:04352410.7VEGFB, HIF1A, RASA1, HMOX1
17BMP signaling pathwayGO:03050910.7SMAD4, ENG, ACVRL1
18positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.7TEK, KDR, FLT1
19vasculogenesisGO:00157010.6ENG, KDR, RASA1
20retina vasculature development in camera-type eyeGO:06129810.6ACVRL1, HIF1A
21protein autophosphorylationGO:04677710.6FLT4, FLT1, KDR, TEK
22positive regulation of endothelial cell proliferationGO:00193810.6FLT4, VEGFB, HIF1A, KDR, ACVRL1, TEK
23response to hypoxiaGO:00166610.6SMAD4, ENG, HIF1A, ANGPTL4
24lymph vessel developmentGO:00194510.6KDR, FLT4
25positive regulation of MAPK cascadeGO:04341010.6FLT4, FLT1, KDR
26positive regulation of angiogenesisGO:04576610.6FLT1, ANGPTL4, HIF1A, HMOX1, KDR, TEK
27wound healing, spreading of epidermal cellsGO:03531310.6MMP12, ACVRL1
28positive regulation of protein kinase B signaling cascadeGO:05189710.6TGFBR1, TEK, VEGFB
29positive regulation of SMAD protein import into nucleusGO:06039110.6TGFBR1, SMAD4
30negative regulation of apoptotic processGO:04306610.6FLT4, VEGFB, ANGPTL4, KDR, TEK, ALB
31angiogenesisGO:00152510.5TGFBR1, VEGFB, ANGPTL4, HIF1A, HMOX1, KDR
32platelet degranulationGO:00257610.5ALB, PECAM1, VEGFB
33lymphangiogenesisGO:00194610.5ACVRL1, FLT4
34negative regulation of endothelial cell apoptotic processGO:200035210.4KDR, TEK
35blood vessel morphogenesisGO:04851410.4FLT1, FLT4
36signal transductionGO:00716510.4HIF1A, RASA1, ACVRL1, TEK, PECAM1, TGFBR1
37positive regulation of focal adhesion assemblyGO:05189410.3KDR, TEK
38endothelial cell proliferationGO:00193510.1HMOX1, TEK

Molecular functions related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:05043110.6TGFBR1, ENG, ACVRL1
2vascular endothelial growth factor-activated receptor activityGO:00502110.6FLT4, FLT1, KDR
3growth factor bindingGO:01983810.6TGFBR1, KDR, FLT1, FLT4
4transforming growth factor beta receptor activity, type IGO:00502510.6TGFBR1, ACVRL1
5transmembrane receptor protein tyrosine kinase activityGO:00471410.6TEK, KDR, FLT1, FLT4
6transforming growth factor beta-activated receptor activityGO:00502410.6ACVRL1, ENG, TGFBR1
7type II transforming growth factor beta receptor bindingGO:00511410.6TGFBR1, ENG
8transmembrane receptor protein serine/threonine kinase activityGO:00467510.5ACVRL1, TGFBR1
9I-SMAD bindingGO:07041110.5TGFBR1, SMAD4
10protein binding transcription factor activityGO:00098810.4SMAD4, HIF1A
11RNA polymerase II transcription factor binding transcription factor activityGO:00107610.3SMAD4, HIF1A
12ATP bindingGO:00552410.2FLT4, FLT1, ABCC5, KDR, ACVRL1, TEK
13activin bindingGO:04818510.1ENG, ACVRL1
14protein bindingGO:00551510.0RASA1, HIF1A, ANGPTL4, VEGFB, FLT1, FLT4

Products for genes affiliated with Arteriovenous Malformation

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arteriovenous Malformation

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet