MCID: ART005
MIFTS: 63

Arteriovenous Malformation malady

Summaries for Arteriovenous Malformation

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33MedlinePlus, 63Wikipedia, 32MalaCards
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MedlinePlus:33 Arteriovenous malformations (avms) are defects in your vascular system. the vascular system includes arteries, veins, and capillaries. arteries carry blood away from the heart to other organs; veins carry blood back to the heart. capillaries connect the arteries and veins. an avm is a snarled tangle of arteries and veins. they are connected to each other, with no capillaries. that interferes with the blood circulation in an organ. avms can happen anywhere, but they are more common in the brain or spinal cord. most people with brain or spinal cord avms have few, if any, major symptoms. sometimes they can cause seizures or headaches. avms are rare. the cause is not known, but they seem to develop during pregnancy or soon after birth. doctors use imaging tests to detect them. medicines can help with the symptoms from avms. the greatest danger is hemorrhage. treatment for avms can include surgery or focused radiation therapy. because surgery can be risky, you and your doctor need to make a decision carefully. nih: national institute of neurological disorders and stroke

MalaCards: Arteriovenous Malformation, also known as arteriovenous malformations, is related to hereditary hemorrhagic telangiectasia and pancreatitis. An important gene associated with Arteriovenous Malformation is RASA1 (RAS p21 protein activator (GTPase activating protein) 1), and among its related pathways are p70S6K Signaling and HIF-2-alpha transcription factor network. The compounds zd6474 and axitinib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related mouse phenotypes are embryogenesis and nervous system.

Wikipedia:63 Arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the... more...

Aliases & Classifications for Arteriovenous Malformation

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Sources:
8Disease Ontology, 20GeneTests, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt
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Aliases & Descriptions:

arteriovenous malformation 8 20 43 10 60
arteriovenous malformations 44 33
arteriovenous hemangioma 8
racemose hemangioma 8
racemose aneurysm 8
cirsoid aneurysm 8
racemose angioma 8


External Ids:

Disease Ontology8 DOID:11294
NCIt39 C4297

Related Diseases for Arteriovenous Malformation

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17GeneCards, 18GeneDecks
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Diseases related to Arteriovenous Malformation via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 301)
idRelated DiseaseScoreTop Affiliating Genes
1hereditary hemorrhagic telangiectasia31.2TGFBR1, ACVRL1, ENG
2pancreatitis30.8SMAD4, ALB
3hypertension30.6ALB
4intracranial aneurysm30.6ENG
5klippel-trenaunay syndrome30.5FLT4, RASA1
6intracranial hemorrhage in brain cerebrovascular malformations30.3FLT1, ENG, KDR, TEK, ACVRL1
7oligodendroglioma30.2FLT1, KDR
8hemangioma30.2SLC2A1, PECAM1, FLT4, TEK, KDR
9ischemia30.2ANGPTL4, VEGFB, FLT1, HIF1A, NGB, TGFBR1
10malignant glioma30.1FLT1, HIF1A, KDR
11hemangioblastoma30.1KDR, FLT1, SLC2A1, HIF1A
12meningioma30.1SLC2A1, MMP12, FLT1
13liver cirrhosis30.1ALB
14astrocytoma30.1HIF1A, FLT1, KDR, SLC2A1, TEK, ENG
15angiodysplasia30.1ENG, ACVRL1
16lung cancer30.1SMAD4, FLT1, HIF1A, MMP12, ABCC5, KDR
17peritonitis29.9PECAM1, ALB
18hepatopulmonary syndrome29.9HMOX1, ALB
19myocardial infarction29.9HIF1A, PECAM1, ENG
20gastrointestinal stromal tumor29.9KDR
21vasculitis29.9ALB
22lymphangioma29.9FLT4, PECAM1
23pituitary adenoma29.9TGFBR1
24primary pulmonary hypertension29.9ACVRL1, HIF1A, TEK, FLT1
25neuropathy29.9ALB
26adenoma29.9TGFBR1, SMAD4, VEGFB, ENG, SLC2A1, FLT1
27cadasil29.9PECAM1, NGB, MMP12, SLC2A1, ENG
28telangiectasis29.9ACVRL1, ENG
29breast cancer29.9ENG, TEK, SLC2A1, ABCC5, HMOX1, HIF1A
30cerebritis11.0
31pulmonary embolism10.7
32hepatitis10.6
33capillary malformation-arteriovenous malformation syndrome10.5
34arteriovenous fistula10.4
35extracranial arteriovenous malformation10.4
36hydrocephalus10.4
37migraine10.4
38pulmonary arteriovenous malformation10.4
39intracranial arteriovenous malformation10.4
40trigeminal neuralgia10.3
41retinitis10.3
42duodenitis10.3
43obstructive hydrocephalus10.3
44hepatitis a10.3
45intracranial hypertension10.3
46papilledema10.3
47moyamoya disease10.2
48intracranial embolism10.2
49brain edema10.2
50cervicitis10.2

Graphical network of the top 20 diseases related to Arteriovenous Malformation:



Diseases related to arteriovenous malformation

Clinical Features for Arteriovenous Malformation

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Drugs & Therapeutics for Arteriovenous Malformation

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Arteriovenous Malformation

Drug clinical trials:

Search ClinicalTrials for Arteriovenous Malformation

Search NIH Clinical Center for Arteriovenous Malformation

Search CenterWatch for Arteriovenous Malformation

Genetic Tests for Arteriovenous Malformation

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20GeneTests
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Genetic tests related to Arteriovenous Malformation:

id Genetic test Affiliating Genes
1 Arteriovenous Malformations20

Anatomical Context for Arteriovenous Malformation

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32MalaCards
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MalaCards organs/tissues related to Arteriovenous Malformation:

32
Brain, Spinal cord, Heart, Testes, Endothelial, Lung, Bone, Liver, Colon, Pancreas, Placenta, Pineal, Temporal lobe, Small intestine, Pituitary, Breast, Thyroid, Cerebellum, Uterus, Kidney, Occipital lobe

Animal Models for Arteriovenous Malformation or affiliated genes

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36MGI
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Publications for Arteriovenous Malformation

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50PubMed
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Articles related to Arteriovenous Malformation:

(show top 50)    (show all 992)
idTitleAuthorsYear
1
Transseptal guidewire stabilization for device closure of a large pulmonary arteriovenous malformation. (22806247)
2013
2
Management of Pulmonary Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia Patients. (24436569)
2013
3
Cerebral arteriovenous malformation: complex 3D hemodynamics and 3D blood flow alterations during staged embolization. (24027116)
2013
4
Massive per rectal bleeding in a child due to caecal arteriovenous malformation treated successfully by embolisation. (23966457)
2013
5
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
6
Intra-arterial injection of indocyanine green in cerebral arteriovenous malformation surgery. (24101318)
2013
7
Onyx embolization of an extensive mandibular arteriovenous malformation via a dual lumen balloon catheter: a technical case report. (22248630)
2013
8
Parkes weber syndrome and spinal arteriovenous malformations. (23928137)
2013
9
Paraspinal arteriovenous malformation Onyx embolization via an Ascent balloon. (23524491)
2013
10
Seizure during embolization of arteriovenous malformation. (22412799)
2012
11
Arteriovenous malformation radiosurgery: now you see it, now you don't. (22120288)
2012
12
Spinal arteriovenous malformation associated with spinal metameric syndrome: a treatable cause of long-term paraplegia? (22225485)
2012
13
Macrophage migration inhibitory factor reduces apoptosis in cerebral arteriovenous malformations. (22206839)
2012
14
Giant non-traumatic arteriovenous malformation of the scalp. (22639692)
2012
15
Brain arteriovenous malformation diagnosis: value of time-resolved contrast-enhanced MR angiography at 3.0T compared to DSA. (22407410)
2012
16
Arteriovenous malformation-associated intracerebral hemorrhage. (22370207)
2012
17
Corpus callosum arteriovenous malformation with persistent trigeminal artery. (21501055)
2011
18
Pulmonary arteriovenous malformation in Osler-Weber-Rendu syndrome. (22100937)
2011
19
Gastrointestinal stromal tumor mimicking arteriovenous malformation of the jejunum. (22110415)
2011
20
Arteriovenous malformation identification after conservative management of placenta percreta with uterine artery embolization and adjunctive therapy. (21349491)
2011
21
Intraoperative magnetic resonance imaging in the successful surgical treatment of an arteriovenous malformation--case report. (21785246)
2011
22
Complication risk of endovascular embolization for cerebral arteriovenous malformation. (20950972)
2011
23
Re: "Comparison of 2 approaches for determining the natural history risk of brain arteriovenous malformation rupture". (21616929)
2011
24
Recurrent cerebral arteriovenous malformation with a posterior inferior cerebellar artery aneurysm. (22194138)
2011
25
Hepatic arteriovenous malformation with hyperammonemia in Rendu-Osler-Weber syndrome. (21961107)
2011
26
Hemothorax due to rupture of pulmonary arteriovenous malformation: an interventional emergency. (20202952)
2010
27
Uterine arteriovenous malformation diagnosed with multislice computed tomography: a case report. (20506681)
2010
28
Mixed pial-dural arteriovenous malformation in the anterior cranial fossa--two case reports. (20587971)
2010
29
Bilateral heterochronic spontaneous hemothorax caused by pulmonary arteriovenous malformation in a gravid: a case report. (21034516)
2010
30
Familial brain arteriovenous malformation maps to 5p13-q14, 15q11-q13 or 18p11: linkage analysis with clipped fingernail DNA on high-density SNP array. (20601259)
2010
31
Report of a scalp arteriovenous malformation spontaneously hemorrhaging into a preauricular sinus. (19224470)
2009
32
The role of echocardiography in prenatal diagnosis of pulmonary arteriovenous malformation. (19340823)
2009
33
Onyx, a new liquid embolic material for peripheral interventions: preliminary experience in aneurysm, pseudoaneurysm, and pulmonary arteriovenous malformation embolization. (17205359)
2007
34
Pulmonary arteriovenous malformation treated with embolotherapy: systemic collateral supply at multidetector CT angiography after 2-20-year follow-up. (17116729)
2007
35
Spontaneous regression of a cerebral arteriovenous malformation in a child with hereditary hemorrhagic telangiectasia. Case report. (17328270)
2006
36
Interleukin-6 involvement in brain arteriovenous malformations. (16278864)
2006
37
Osseous regeneration after embolization of mandibular arteriovenous malformation. (15008331)
2003
38
Hemoptysis from an unusual pulmonary arteriovenous malformation. (14602328)
2003
39
Spontaneous regression of cerebral arteriovenous malformation in hereditary hemorrhagic telangiectasia. (12063239)
2002
40
Renal arteriovenous malformation requiring surgery in Rendu-Osler-Weber disease (hereditary hemorrhagic telangiectasia). (10992384)
2000
41
Diffuse pulmonary arteriovenous malformation: unusual cause of cyanosis in infancy. (17322714)
2000
42
Acquired cerebral arteriovenous malformation induced by an anaplastic astrocytoma: an interesting case. (10935219)
2000
43
Neuroradiology case of the day. Multiple cerebral abscesses associated with isolated pulmonary arteriovenous malformation. (9207557)
1997
44
Resolution of cavopulmonary shunt-associated pulmonary arteriovenous malformation after heart transplantation. (9436140)
1997
45
Spontaneous regression of intracranial arteriovenous malformation on PET. (8862306)
1996
46
Acute hemothorax owing to pulmonary arteriovenous malformation in pregnancy. (1554132)
1992
47
The management of caesarean section in a patient with an intracranial arteriovenous malformation. (2667389)
1989
48
Superior mesenteric artery syndrome after resection of an arteriovenous malformation in the cervical cord. (3631039)
1987
49
Non-communicating hydrocephalus caused by dural arteriovenous malformation. (316203)
1979
50
Cerebral abscess secondary to pulmonary arteriovenous malformation. (4656363)
1972

Genetic Variations for Arteriovenous Malformation

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Expression for genes affiliated with Arteriovenous Malformation

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arteriovenous Malformation

Search GEO for disease gene expression data for Arteriovenous Malformation.

Pathways for genes affiliated with Arteriovenous Malformation

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51QIAGEN, 37NCBI BioSystems Database, 55SinoBiological, 4Cell Signaling Technology, 49PharmGKB, 59Tocris Bioscience, 53Reactome, 52R&D Systems, 12EMD Millipore, 29KEGG
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Pathways related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show all 41)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TIMP4
210.4SLC2A1, FLT1
310.4ACVRL1, ENG, TGFBR1
410.4TGFBR1, SMAD4, ENG
510.4ENG, SMAD4, TGFBR1
610.4ACVRL1, SMAD4, TGFBR1
7
Hide members
10.3FLT4, FLT1, KDR
810.3KDR, VEGFB, FLT4
9
Hide members
10.3VEGFB, PECAM1, ALB
1010.3TGFBR1, SMAD4, ENG, ACVRL1
1110.3ACVRL1, ENG, SMAD4, TGFBR1
1210.3VEGFB, HIF1A, SLC2A1
13
Hide members
10.3FLT4, FLT1, KDR, TGFBR1
1410.3FLT4, FLT1, KDR, TEK
15
Hide members
10.3TEK, KDR, FLT1, FLT4
1610.3FLT1, KDR, ACVRL1, SMAD4
1710.3FLT1, HIF1A, KDR, TEK
18
Hide members
10.3KDR, VEGFB, FLT1, FLT4
19
Hide members
10.3KDR, VEGFB, FLT1, FLT4
20
Hide members
10.3FLT4, FLT1, VEGFB, KDR
21
Hide members
10.3FLT4, FLT1, VEGFB, KDR
22
Hide members
10.3KDR, VEGFB, FLT1, FLT4
2310.3HIF1A, HMOX1, SLC2A1, ENG, SMAD4
2410.2TEK, KDR, VEGFB, FLT1, FLT4
2510.2FLT1, HIF1A, HMOX1, SLC2A1, TEK
2610.2VEGFB, HIF1A, SLC2A1, SMAD4, TGFBR1
27
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, TEK
28
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR
29
Hide members
10.2FLT4, FLT1, VEGFB, KDR, ACVRL1, TEK
30
Hide members
10.2FLT4, FLT1, VEGFB, HIF1A, RASA1, KDR
31
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR, TGFBR1
32
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR, TGFBR1
33
Hide members
10.2TIMP4, FLT4, FLT1, VEGFB, KDR, TEK
34
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, TEK
35
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, TEK
36
Hide members
10.1FLT4, FLT1, VEGFB, HIF1A, RASA1, KDR
37
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, ACVRL1
38
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, KDR, SLC2A1
39
Hide members
10.1TIMP4, FLT4, FLT1, VEGFB, MMP12, RASA1
4010.0TGFBR1, FLT4, FLT1, VEGFB, HIF1A, HMOX1
41
Hide members
10.0TIMP4, FLT4, FLT1, VEGFB, HIF1A, RASA1

Compounds for genes affiliated with Arteriovenous Malformation

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44Novoseek, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 28IUPHAR, 24HMDB, 2BitterDB
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Compounds related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1zd64744410.8KDR, FLT1, FLT4
2axitinib44 59 1112.7KDR, FLT1, FLT4
3su54164410.7FLT4, FLT1, HIF1A, KDR
4Regorafenib1110.7FLT4, FLT1, KDR, TEK
5Pazopanib1110.7KDR, FLT1, FLT4
6sunitinib44 49 1112.7KDR, HIF1A, FLT1, FLT4
7cobalt chloride4410.7SLC2A1, HMOX1, HIF1A
8heparin44 28 11 2413.7FLT1, SLC2A1, PECAM1, TGFBR1
9ki 87515910.7FLT1, FLT4
10zm 323881 hydrochloride5910.7FLT1, FLT4
11zm 306416 hydrochloride5910.7FLT1, FLT4
12tgf beta14410.7FLT1, KDR, ACVRL1, ENG, SMAD4, TGFBR1
13dmh45910.7FLT4, FLT1
14vegfe2810.7FLT4, KDR
15agar4410.6HIF1A, KDR, SLC2A1, ENG, PECAM1, SMAD4
16matrigel4410.6FLT4, FLT1, HIF1A, KDR, TEK, PECAM1
17vegfa2810.6FLT1, KDR
18dexamethasone44 49 28 1113.6HIF1A, MMP12, KDR, SLC2A1, ENG, TGFBR1
19vegfc2810.6FLT4, KDR
20ly2940024410.6FLT4, HIF1A, HMOX1, KDR, SLC2A1, TGFBR1
21adp44 28 2412.6FLT4, ACVRL1, TEK, PECAM1, TGFBR1
22ribonucleic acid4410.6FLT1, SLC2A1, TEK, PECAM1, TGFBR1
23rapamycin4410.6FLT4, FLT1, HIF1A, KDR, SLC2A1, PECAM1
24glucose4410.6FLT1, HIF1A, NGB, SLC2A1, SMAD4, TGFBR1
25doxorubicin44 49 1112.6FLT1, HIF1A, ABCC5, HMOX1, KDR, ENG
26genistein44 28 59 2 11 2415.6FLT1, HIF1A, MMP12, KDR, SLC2A1, TGFBR1
27lactate4410.6HIF1A, HMOX1, KDR, SLC2A1, SMAD4, ALB
28ascorbic acid44 2411.6HIF1A, HMOX1, SLC2A1, ENG, ALB
29thymidine44 2411.6FLT1, HIF1A, KDR, TEK, PECAM1, SMAD4
30cisplatin44 49 59 1113.5FLT1, HIF1A, ABCC5, HMOX1, KDR, SLC2A1
31azd 21714410.5KDR, FLT4
32threonine4410.5HIF1A, ACVRL1, TEK, ENG, PECAM1, SMAD4
33serine4410.5FLT1, MMP12, RASA1, SLC2A1, ACVRL1, TEK
34phosphatidylinositol4410.5FLT1, HIF1A, MMP12, RASA1, KDR, SLC2A1
35p0024410.5FLT1, TEK, ENG, PECAM1
36paraffin4410.5FLT4, FLT1, HIF1A, KDR, SLC2A1, TEK
37alanine4410.5HIF1A, RASA1, HMOX1, SLC2A1, SMAD4, ALB
38nitric oxide44 11 2412.4FLT1, HIF1A, NGB, MMP12, HMOX1, KDR
39cysteine4410.4ANGPTL4, HIF1A, NGB, HMOX1, KDR, SLC2A1
40mg 13244 5911.4HIF1A, HMOX1, KDR, SMAD4
41oxygen44 2411.4FLT4, FLT1, VEGFB, HIF1A, NGB, MMP12
42lipid4410.4FLT1, ANGPTL4, NGB, MMP12, ENG, PECAM1
43wogonin4410.4KDR, FLT1
44dihydrotestosterone44 28 11 2413.4HIF1A, ENG, SMAD4, TGFBR1
45h2o24410.4FLT1, HIF1A, NGB, HMOX1, KDR, PECAM1
46tyrosine4410.3MMP12, HIF1A, VEGFB, FLT1, FLT4, RASA1
47rotenone4410.3SLC2A1, HMOX1, HIF1A
48vegf4410.3TGFBR1, FLT4, FLT1, VEGFB, HIF1A, MMP12
49oligonucleotide4410.1HIF1A, MMP12, ACVRL1, ENG, SMAD4, TGFBR1
50prostacyclin4410.0FLT1, HMOX1, KDR, PECAM1

GO Terms for genes affiliated with Arteriovenous Malformation

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16Gene Ontology
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Cellular components related to Arteriovenous Malformation according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588710.2FLT1, ABCC5, KDR, ACVRL1, TEK, FLT4
2transforming growth factor beta receptor homodimeric complexGO:07002210.1TGFBR1, ENG
3extracellular spaceGO:00561510.1ALB, TIMP4, FLT1, VEGFB, ANGPTL4, HMOX1
4extracellular regionGO:00557610.0TIMP4, FLT4, VEGFB, ANGPTL4, MMP12, KDR

Biological processes related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show all 38)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of protein phosphorylationGO:00193410.8KDR, FLT4
2cellular response to vascular endothelial growth factor stimulusGO:03592410.7FLT4, FLT1, KDR
3positive regulation of pathway-restricted SMAD protein phosphorylationGO:01086210.7ACVRL1, ENG, SMAD4, TGFBR1
4positive regulation of BMP signaling pathwayGO:03051310.7SMAD4, ENG, ACVRL1
5sprouting angiogenesisGO:00204010.7TEK, FLT1, FLT4
6negative regulation of endothelial cell proliferationGO:00193710.7TGFBR1, ENG, ACVRL1
7positive regulation of vascular endothelial growth factor receptor signaling pathwayGO:03094910.7HIF1A, VEGFB, FLT1
8peptidyl-tyrosine phosphorylationGO:01810810.7TEK, KDR, FLT1, FLT4
9regulation of transforming growth factor beta2 productionGO:03290910.7SMAD4, HIF1A
10transmembrane receptor protein tyrosine kinase signaling pathwayGO:00716910.7FLT4, FLT1, KDR, TEK
11positive regulation of endothelial cell migrationGO:01059510.7FLT4, KDR, TEK
12vascular endothelial growth factor receptor signaling pathwayGO:04801010.7KDR, VEGFB, FLT1, FLT4
13regulation of transcription from RNA polymerase II promoter in response to oxidative stressGO:04361910.7HIF1A, HMOX1
14transforming growth factor beta receptor signaling pathwayGO:00717910.7ACVRL1, ENG, SMAD4, TGFBR1
15positive regulation of ERK1 and ERK2 cascadeGO:07037410.7FLT4, VEGFB, KDR, TEK
16negative regulation of neuron apoptotic processGO:04352410.7VEGFB, HIF1A, RASA1, HMOX1
17BMP signaling pathwayGO:03050910.7SMAD4, ENG, ACVRL1
18positive regulation of phosphatidylinositol 3-kinase cascadeGO:01406810.7TEK, KDR, FLT1
19vasculogenesisGO:00157010.6ENG, KDR, RASA1
20retina vasculature development in camera-type eyeGO:06129810.6ACVRL1, HIF1A
21protein autophosphorylationGO:04677710.6FLT4, FLT1, KDR, TEK
22positive regulation of endothelial cell proliferationGO:00193810.6FLT4, VEGFB, HIF1A, KDR, ACVRL1, TEK
23response to hypoxiaGO:00166610.6SMAD4, ENG, HIF1A, ANGPTL4
24lymph vessel developmentGO:00194510.6KDR, FLT4
25positive regulation of MAPK cascadeGO:04341010.6FLT4, FLT1, KDR
26positive regulation of angiogenesisGO:04576610.6FLT1, ANGPTL4, HIF1A, HMOX1, KDR, TEK
27wound healing, spreading of epidermal cellsGO:03531310.6MMP12, ACVRL1
28positive regulation of protein kinase B signaling cascadeGO:05189710.6TGFBR1, TEK, VEGFB
29positive regulation of SMAD protein import into nucleusGO:06039110.6TGFBR1, SMAD4
30negative regulation of apoptotic processGO:04306610.6FLT4, VEGFB, ANGPTL4, KDR, TEK, ALB
31angiogenesisGO:00152510.5TGFBR1, VEGFB, ANGPTL4, HIF1A, HMOX1, KDR
32platelet degranulationGO:00257610.5ALB, PECAM1, VEGFB
33lymphangiogenesisGO:00194610.5ACVRL1, FLT4
34negative regulation of endothelial cell apoptotic processGO:200035210.4KDR, TEK
35blood vessel morphogenesisGO:04851410.4FLT1, FLT4
36signal transductionGO:00716510.4HIF1A, RASA1, ACVRL1, TEK, PECAM1, TGFBR1
37positive regulation of focal adhesion assemblyGO:05189410.3KDR, TEK
38endothelial cell proliferationGO:00193510.1HMOX1, TEK

Molecular functions related to Arteriovenous Malformation according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1transforming growth factor beta bindingGO:05043110.6TGFBR1, ENG, ACVRL1
2vascular endothelial growth factor-activated receptor activityGO:00502110.6FLT4, FLT1, KDR
3growth factor bindingGO:01983810.6TGFBR1, KDR, FLT1, FLT4
4transforming growth factor beta receptor activity, type IGO:00502510.6TGFBR1, ACVRL1
5transmembrane receptor protein tyrosine kinase activityGO:00471410.6TEK, KDR, FLT1, FLT4
6transforming growth factor beta-activated receptor activityGO:00502410.6ACVRL1, ENG, TGFBR1
7type II transforming growth factor beta receptor bindingGO:00511410.6TGFBR1, ENG
8transmembrane receptor protein serine/threonine kinase activityGO:00467510.5ACVRL1, TGFBR1
9I-SMAD bindingGO:07041110.5TGFBR1, SMAD4
10protein binding transcription factor activityGO:00098810.4SMAD4, HIF1A
11RNA polymerase II transcription factor binding transcription factor activityGO:00107610.3SMAD4, HIF1A
12ATP bindingGO:00552410.2FLT4, FLT1, ABCC5, KDR, ACVRL1, TEK
13activin bindingGO:04818510.1ENG, ACVRL1
14protein bindingGO:00551510.0RASA1, HIF1A, ANGPTL4, VEGFB, FLT1, FLT4

Products for genes affiliated with Arteriovenous Malformation

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  • Antibodies
  • Proteins
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  • Antibodies

Sources for Arteriovenous Malformation

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet