AVM
MCID: ART005
MIFTS: 66

Arteriovenous Malformation (AVM) malady

Categories: Genetic diseases, Cancer diseases

Aliases & Classifications for Arteriovenous Malformation

Aliases & Descriptions for Arteriovenous Malformation:

Name: Arteriovenous Malformation 12 51 14
Arteriovenous Malformations 24 29 52 41
Arteriovenous Hemangioma 12 69
Congenital Arteriovenous Malformation 69
Cerebral Arteriovenous Malformations 24
Arteriovenous Malformations Cerebral 52
Racemose Hemangioma 12
Racemose Aneurysm 12
Cirsoid Aneurysm 12
Racemose Angioma 12
Avm 24

Classifications:



External Ids:

Disease Ontology 12 DOID:11294
ICD10 33 I77.0
NCIt 47 C2882
UMLS 69 C0334533

Summaries for Arteriovenous Malformation

MedlinePlus : 41 arteriovenous malformations (avms) are defects in your vascular system. the vascular system includes arteries, veins, and capillaries. arteries carry blood away from the heart to other organs; veins carry blood back to the heart. capillaries connect the arteries and veins. an avm is a snarled tangle of arteries and veins. they are connected to each other, with no capillaries. that interferes with the blood circulation in an organ. avms can happen anywhere, but they are more common in the brain or spinal cord. most people with brain or spinal cord avms have few, if any, major symptoms. sometimes they can cause seizures or headaches. avms are rare. the cause is not known, but they seem to develop during pregnancy or soon after birth. doctors use imaging tests to detect them. medicines can help with the symptoms from avms. the greatest danger is hemorrhage. treatment for avms can include surgery or focused radiation therapy. because surgery can be risky, you and your doctor need to make a decision carefully. nih: national institute of neurological disorders and stroke

MalaCards based summary : Arteriovenous Malformation, also known as arteriovenous malformations, is related to retinal degeneration and myocardial infarction, and has symptoms including angina pectoris, back pain and chest pain. An important gene associated with Arteriovenous Malformation is RASA1 (RAS P21 Protein Activator 1), and among its related pathways/superpathways are Signaling by GPCR and ERK Signaling. The drugs Dexmedetomidine and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and heart, and related phenotypes are Decreased viability and cardiovascular system

NINDS : 51 Arteriovenous malformations (AVMs) are abnormal, snarled tangles of blood vessels that cause multiple irregular connections between the arteries and veins.  These malformations most often occur in the spinal cord and in any part of the brain or on its surface, but can develop elsewhere in the body. AVMs can damage the brain and spinal cord by reducing the amount of oxygen reaching neurological tissues, bleeding into surrounding tissue (hemorrhage) that can cause stroke or brain damage, and by compressing or displacing parts of the brain or spinal cord.  Many people with an AVM experience few, if any, significant symptoms, which can include headache, weakness, seizures, pain, and problems with speech, vision, or movement.  Most often AVMs are congenital, but they can appear sporadically.  In some cases the AVM may be inherited, but it is more likely that other inherited conditions increase the risk of having an AVM.  The malformations tend to be discovered only incidentally, usually during treatment for an unrelated disorder or at autopsy.

Disease Ontology : 12 An anomalous configuration of blood vessels that shunts arterial blood directly into veins by bypassing the capillary system.

Wikipedia : 71 Arteriovenous malformation (AVM) is an abnormal connection between arteries and veins, bypassing the... more...

Related Diseases for Arteriovenous Malformation

Diseases related to Arteriovenous Malformation via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 309)
id Related Disease Score Top Affiliating Genes
1 retinal degeneration 29.3 ENG IL6 TEK VEGFA
2 myocardial infarction 29.0 IL6 MMP3 MMP9 TGFB1 VEGFA
3 capillary malformation-arteriovenous malformation 12.5
4 pulmonary arteriovenous malformation 12.3
5 extracranial arteriovenous malformation 12.3
6 mandibular arteriovenous malformation 12.1
7 maxillary arteriovenous malformation 12.1
8 intracranial hemorrhage in brain cerebrovascular malformations 12.0
9 facial arteriovenous malformation 12.0
10 frontonasal arteriovenous malformation 12.0
11 segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome 11.9
12 vein of galen aneurysm 11.9
13 hereditary hemorrhagic telangiectasia 11.4
14 cobb syndrome 11.4
15 pulmonary arteriovenous fistulas 11.2
16 wyburn mason's syndrome 11.2
17 telangiectasia, hereditary hemorrhagic, type 1 11.1
18 telangiectasia, hereditary hemorrhagic, type 5 11.1
19 clove syndrome, somatic 11.0
20 telangiectasia, hereditary hemorrhagic, type 2 11.0
21 dural sinus malformation 10.9
22 cerebral cavernous malformations-1 10.8
23 noonan syndrome 1 10.8
24 hemorrhage, intracerebral 10.8
25 superficial siderosis of the central nervous system 10.8
26 juvenile polyposis/hereditary hemorrhagic telangiectasia syndrome 10.8
27 vascular malformation 10.8
28 cerebritis 10.6
29 aneurysm 10.4
30 pulmonary surfactant protein b, deficiency of 10.3 ACVRL1 ENG
31 solitary osseous plasmacytoma 10.2 PTEN VEGFA
32 right atrium familial dilatation 10.2 MMP3 MMP9
33 weyers ulnar ray/oligodactyly syndrome 10.2 ACVRL1 ENG RASA1
34 tooth erosion 10.2 ACVRL1 ENG VEGFA
35 pancreatitis 10.2
36 kidney osteogenic sarcoma 10.2 MMP9 RASA1 VEGFA
37 kleptomania 10.2 MMP3 MMP9
38 hepatitis 10.2
39 endotheliitis 10.2
40 central nervous system adult germ cell tumor 10.2 MMP3 MMP9
41 epididymis cancer 10.2 ENG TGFB1
42 urinary bladder posterior wall cancer 10.2 ACVRL1 IL6 VEGFA
43 atherosclerosis 10.2 IL6 RASA1
44 neonatal hypoxic and ischemic brain injury 10.2 IL6 MMP9
45 laryngeal adenoid cystic carcinoma 10.2 ENG VEGFA
46 hyperinsulinism 10.2 ANGPT2 VEGFA
47 leukoplakia of vagina 10.2 IL6 MMP9 VEGFA
48 vesiculobullous skin disease 10.1 RASA1 TEK VEGFA
49 marginal zone b-cell lymphoma 10.1 MMP9 PTEN VEGFA
50 submucous uterine fibroid 10.1 ANGPT2 VEGFA

Graphical network of the top 20 diseases related to Arteriovenous Malformation:



Diseases related to Arteriovenous Malformation

Symptoms & Phenotypes for Arteriovenous Malformation

UMLS symptoms related to Arteriovenous Malformation:


angina pectoris, back pain, chest pain, edema, headache, pain, sciatica, seizures, syncope, tremor, chronic pain, vertigo/dizziness, sleeplessness

GenomeRNAi Phenotypes related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.4 BMPR2
2 Decreased viability GR00221-A-1 9.4 ACVRL1 BMPR2
3 Decreased viability GR00221-A-2 9.4 ACVRL1
4 Decreased viability GR00221-A-3 9.4 ACVRL1 BMPR2 RASA1 TEK
5 Decreased viability GR00221-A-4 9.4 ACVRL1 BMPR2
6 Decreased viability GR00301-A 9.4 BMPR2
7 Decreased viability GR00381-A-1 9.4 RASA1

MGI Mouse Phenotypes related to Arteriovenous Malformation:

44 (show all 18)
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.35 RASA1 TEK TGFB1 THBS1 VEGFA ACVRL1
2 homeostasis/metabolism MP:0005376 10.29 ACVRL1 ANGPT2 BMPR2 ENG IL6 MMP3
3 growth/size/body region MP:0005378 10.28 RASA1 TEK TGFB1 THBS1 VEGFA ACVRL1
4 digestive/alimentary MP:0005381 10.26 ACVRL1 ANGPT2 ENG IL6 MMP9 PTEN
5 hematopoietic system MP:0005397 10.26 MMP3 MMP9 PTEN TEK TGFB1 THBS1
6 cellular MP:0005384 10.22 ANGPT2 BMPR2 IL6 MMP9 PTEN RASA1
7 mortality/aging MP:0010768 10.21 ACVRL1 ANGPT2 BMPR2 ENG IL6 MMP9
8 immune system MP:0005387 10.19 ANGPT2 BMPR2 IL6 MMP3 MMP9 PTEN
9 embryo MP:0005380 10.15 ACVRL1 BMPR2 ENG PTEN RASA1 TEK
10 muscle MP:0005369 10.14 ACVRL1 BMPR2 ENG IL6 MMP9 PTEN
11 integument MP:0010771 10.08 ANGPT2 ENG IL6 MMP9 PTEN TGFB1
12 nervous system MP:0003631 10.06 TGFB1 VEGFA ACVRL1 BMPR2 ENG IL6
13 liver/biliary system MP:0005370 9.93 ACVRL1 IL6 PTEN TGFB1 THBS1 VEGFA
14 renal/urinary system MP:0005367 9.86 ACVRL1 BMPR2 IL6 MMP9 PTEN TGFB1
15 neoplasm MP:0002006 9.85 IL6 MMP9 PTEN TGFB1 THBS1 VEGFA
16 respiratory system MP:0005388 9.85 ACVRL1 ANGPT2 BMPR2 ENG IL6 MMP9
17 skeleton MP:0005390 9.61 BMPR2 IL6 MMP3 MMP9 PTEN RASA1
18 vision/eye MP:0005391 9.23 THBS1 VEGFA ANGPT2 IL6 MMP9 PTEN

Drugs & Therapeutics for Arteriovenous Malformation

Drugs for Arteriovenous Malformation (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 147)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
2
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
3
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
4
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
5
Bacitracin Approved, Vet_approved Phase 4 1405-87-4 439542 10909430
6
Tranexamic Acid Approved Phase 4 1197-18-8 5526
7
Ethanol Approved Phase 4 64-17-5 702
8
Heparin Approved, Investigational Phase 4,Phase 2 9005-49-6 772 46507594
9
Nitroglycerin Approved, Investigational Phase 4 55-63-0 4510
10
Sufentanil Approved, Investigational Phase 4 56030-54-7 41693
11
Ethiodized oil Approved Phase 4 8008-53-5
12 Adrenergic Agents Phase 4
13 Adrenergic Agonists Phase 4
14 Adrenergic alpha-2 Receptor Agonists Phase 4
15 Adrenergic alpha-Agonists Phase 4
16 Analgesics Phase 4
17 Analgesics, Non-Narcotic Phase 4
18 Anesthetics Phase 4
19 Anesthetics, General Phase 4
20 Anesthetics, Intravenous Phase 4
21 Central Nervous System Depressants Phase 4
22 Hypnotics and Sedatives Phase 4
23 Neurotransmitter Agents Phase 4,Phase 1,Phase 2
24 Peripheral Nervous System Agents Phase 4
25 Anesthetics, Local Phase 4
26 Anti-Arrhythmia Agents Phase 4
27 Diuretics, Potassium Sparing Phase 4
28 Sodium Channel Blockers Phase 4
29 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Phase 1
30 Antifibrinolytic Agents Phase 4
31 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Anti-Infective Agents, Local Phase 4
33 Coagulants Phase 4
34 Hemostatics Phase 4
35 Anticoagulants Phase 4,Phase 2
36 calcium heparin Phase 4,Phase 2
37 Calcium, Dietary Phase 4,Phase 2
38 Fibrinolytic Agents Phase 4,Phase 2
39 Vasodilator Agents Phase 4
40 Pharmaceutical Solutions Phase 4,Phase 2
41 Adjuvants, Anesthesia Phase 4
42 Analgesics, Opioid Phase 4
43 Narcotics Phase 4
44 Ferrosoferric Oxide Phase 4
45 Hematinics Phase 4
46 Parenteral Nutrition Solutions Phase 4
47
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
48
Bevacizumab Approved, Investigational Phase 2, Phase 3,Phase 1 216974-75-3
49
Everolimus Approved Phase 3,Phase 2 159351-69-6 6442177
50
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 2 22916-47-8 4189

Interventional clinical trials:

(show top 50) (show all 162)
id Name Status NCT ID Phase
1 Dexmedetomidine and Propofol As Sole Sedative Agent for Patients Undergoing Arteriovenous Fistula Surgery Unknown status NCT02447796 Phase 4
2 2% Lidocaine Plus 0.5% Bupivacaine Versus 0.5% Bupivacaine in Brachial Block for Creation of Arteriovenous (AV) Fistula Unknown status NCT00993746 Phase 4
3 Use of Topical Tranexamic Acid and Bacitracin in Dialysis Patients Unknown status NCT02106962 Phase 4
4 A Prospective Study Comparing Contour SE™ Microspheres to Embosphere® Microspheres for Treating Symptomatic Uterine Fibroids With Uterine Fibroid Embolization (UFE) Completed NCT00628901 Phase 4
5 Effects of Heparin on Arteriovenous Fistula Patency Completed NCT02493504 Phase 4
6 The Use of Glyceryl Trinitrate Patches in Arteriovenous Fistulas Completed NCT01685710 Phase 4
7 Effect of Dexmedetomidine Combined With Sufentanil for Postoperative Intravenous Analgesia in Neurosurgery Recruiting NCT02552459 Phase 4
8 Yellow 560 Microscope for Intraoperative Visualization of Fluorescein Stained Intracranial Lesions Recruiting NCT02478346 Phase 4
9 Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Recruiting NCT02729740 Phase 4
10 Ferumoxytol Enhanced Magnetic Resonance Angiography in Chronic Kidney Disease Recruiting NCT02997046 Phase 4
11 Apollo™ Onyx™ Delivery Micro Catheter Post Market Safety Study Active, not recruiting NCT02378883 Phase 4
12 Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Not yet recruiting NCT02079818 Phase 4
13 Evaluation of Lipiodol® Ultra Fluid in Association With Surgical Glues During Vascular Embolization. Not yet recruiting NCT02625389 Phase 4
14 Functional Magnetic Resonance Imagine(fMRI)Navigation in Intracranial Arteriovenous Malformation Surgery Unknown status NCT01758211 Phase 3
15 A Multicenter, Open-label Study for E7040 in Japanese Subjects With Hypervascular Tumor and Subjects With Arteriovenous Malformation Completed NCT01677624 Phase 3
16 A Randomized Trial of Unruptured Brain AVMs Completed NCT00389181 Phase 3
17 Safety and Efficacy Study of the Venous Window Needle Guide to Access Arteriovenous (AV)Fistulae Completed NCT01471041 Phase 2, Phase 3
18 Percutaneous Less Invasive AV Fistula for Vascular Access in ESRD Completed NCT02363972 Phase 3
19 Feasibility Study of Phase-contrast MRI for Flow in the External Carotid Branches Arteries Recruiting NCT02829190 Phase 3
20 Paclitaxel-coated Balloon Angioplasty Versus Standard Angioplasty for the Treatment of Stenosis of Arteriovenous Fistula Recruiting NCT02753998 Phase 3
21 Primary Patency in Post-angioplasty Dysfunctional Arteriovenous Fistula in Renal Dialysis: Paclitaxel-releasing PTA Balloon Catheter vs PTA Balloon Recruiting NCT02565953 Phase 3
22 A Study of Vonapanitase (PRT-201) Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-2) Recruiting NCT02414841 Phase 3
23 Preoperative Arteriovenous Fistula Simulation Study (ShuntSimulationStudy) Recruiting NCT02453412 Phase 2, Phase 3
24 Safety and Efficacy of the Sirolimus-Eluting Collagen Implant to Assess AV Fistula Outcomes in Patients on Hemodialysis Recruiting NCT02513303 Phase 3
25 Study Comparing Lutonix AV Drug Coated Balloon vs Standard Balloon for Treatment of Dysfunctional AV Fistulae Active, not recruiting NCT02440022 Phase 3
26 A Study of PRT-201 Administered Immediately After Radiocephalic Arteriovenous Fistula(AVF) Creation in Patients With Chronic Kidney Disease (CKD) (PATENCY-1) Active, not recruiting NCT02110901 Phase 3
27 Arteriovenous Fistula: Conventional Angioplasty vs Drug Eluting Balloon-assisted Maturation Intervention Clinical Trial Not yet recruiting NCT03068845 Phase 3
28 Efficacy of a Bevacizumab Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) Terminated NCT02106520 Phase 2, Phase 3
29 Zero Ischemia Laparoscopic Partial Nephrectomy Withdrawn NCT02634385 Phase 2, Phase 3
30 Treatment of Hereditary Hemorrhagic Telangiectasia of the Nasal Mucosa by Intranasal Bevacizumab : Search for Effective Dose Unknown status NCT02157987 Phase 1, Phase 2
31 Study Comparing Onyx and TRUFILL in Brain Arteriovenous Malformations (AVMs) Completed NCT00857662 Phase 2
32 Thalidomide Reduces Arteriovenous Malformation Related Gastrointestinal Bleeding Completed NCT00389935 Phase 2
33 An Efficacy and Safety Study of SRM003 in the Treatment of Subjects Undergoing Creation of an Arteriovenous Fistula to Facilitate Hemodialysis Access Completed NCT01806545 Phase 2
34 A Study of PRT-201 Administered Immediately After Arteriovenous Fistula Creation in Patients With Chronic Kidney Disease Completed NCT01305824 Phase 2
35 A Phase 1-2 Study of PRT-201 Administered in Chronic Kidney Disease (CKD) Patients Completed NCT00679991 Phase 1, Phase 2
36 Prospective Evaluation of the Efficacy of Sirolimus (Rapamune®) in the Treatment of Severe Arteriovenous Malformations Recruiting NCT02042326 Phase 2
37 Proton Radiotherapy for Primary Central Nervous System Tumours in Adults Recruiting NCT02797366 Phase 2
38 Delivery of Inhibitors of Lysyl Oxidase (LysoLox) on Serial Angioplasty and Time to Restenosis Recruiting NCT03106948 Phase 2
39 Vascular Protective Effect of Rosuvastatin in Arteriovenous Fistula Recruiting NCT01863914 Phase 2
40 Determine the Safety/Efficacy of Ticagrelor for Maintaining Patency of Arterio-Venous Fistulae Created for Hemodialysis Recruiting NCT02335099 Phase 1, Phase 2
41 Efficacy of Thalidomide in the Treatment of Hereditary Hemorrhagic Telangiectasia Active, not recruiting NCT01485224 Phase 2
42 Efficacy and Local Tolerability of Topically Applied Heparin on the Suitability of Newly Constructed Primary Arteriovenous Fistulas in Patients Planned for Haemodialysis Terminated NCT01382888 Phase 2
43 Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms Completed NCT00243893 Phase 1
44 Influence of MMP on Brain AVM Hemorrhage Completed NCT00783523 Phase 1
45 Phase I Drug Trial for S/E of Marimastat in Disabling Malformations When no Other Options. Completed NCT00261391 Phase 1
46 Bevacizumab Therapy for Brain Arteriovenous Malformation Recruiting NCT02314377 Phase 1
47 Clinical Translation of a Novel Albumin-Binding PET Radiotracer 68Ga-NEB Recruiting NCT02496013 Phase 1
48 Autologous Adipose Derived Mesenchymal Stem Cells (AMSC) in Reducing Hemodialysis Arteriovenous Fistula Failure Not yet recruiting NCT02808208 Phase 1
49 Nationwide Treatment Survey of Intracranial Arteriovenous Malformation in China Unknown status NCT01803685
50 Identification of Genetic and Cellular Markers Associated With Vascular Endothelial Modifications in Cutaneous Arteriovenous Malformations Unknown status NCT01774916

Search NIH Clinical Center for Arteriovenous Malformation

Genetic Tests for Arteriovenous Malformation

Genetic tests related to Arteriovenous Malformation:

id Genetic test Affiliating Genes
1 Arteriovenous Malformation 29
2 Arteriovenous Malformations 24

Anatomical Context for Arteriovenous Malformation

MalaCards organs/tissues related to Arteriovenous Malformation:

39
Brain, Spinal Cord, Heart, Testes, Endothelial, Lung, Bone

Publications for Arteriovenous Malformation

Articles related to Arteriovenous Malformation:

(show top 50) (show all 1204)
id Title Authors Year
1
A Survey of Pulmonary Arteriovenous Malformation Screening, Management, and Follow-Up in Hereditary Hemorrhagic Telangiectasia Centers of Excellence. ( 28188364 )
2017
2
Unilateral moyamoya disease with co-existing arteriovenous malformation. ( 28084278 )
2017
3
5q14.3 Microdeletions: A Contiguous Gene Syndrome with Capillary Malformation-Arteriovenous Malformation Syndrome and Neurologic Findings. ( 28297145 )
2017
4
Somatic MAP2K1 Mutations Are Associated with Extracranial Arteriovenous Malformation. ( 28190454 )
2017
5
Arteriovenous malformation and thyroid metastasis from underlying renal cell carcinoma, an unusual presentation of malignancy: A case report. ( 28521439 )
2017
6
Spontaneous occlusion of cerebral arteriovenous malformation following partial embolization with Onyx. ( 28059672 )
2016
7
Embolosclerotherapy by the Transvenous Approach for Lower Extremity Arteriovenous Malformation in Cowden Syndrome: A Case Report. ( 27087878 )
2016
8
Hypervascular glioblastoma multiforme or arteriovenous malformation associated Glioma? A diagnostic and therapeutic challenge: A case report. ( 27999714 )
2016
9
Regarding "Amplatzer Vascular Plugs Versus Coils for Embolization of Pulmonary Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia". ( 27501797 )
2016
10
Giant scalp arteriovenous malformation. ( 28001255 )
2016
11
Three-Dimensional Printed Modeling of an Arteriovenous Malformation Including Blood Flow. ( 27060520 )
2016
12
EP29.13: Diagnosis and management of congenital uterine arteriovenous malformation (UAVM): case report. ( 27647652 )
2016
13
Immunohistochemical Analysis of Sox17 Associated Pathway in Brain Arteriovenous Malformations. ( 26463399 )
2016
14
Uterine arteriovenous malformation: A rare cause of abnormal uterine bleeding in a post-menopausal female. ( 28050115 )
2016
15
EP29.14: Colour Doppler diagnosis of cervical arteriovenous malformation case report. ( 27647669 )
2016
16
Developmental venous anomaly, capillary telangiectasia, cavernous malformation, and arteriovenous malformation: spectrum of a common pathological entity? ( 26743915 )
2016
17
Chronic Encapsulated Expanding Thalamic Hematoma Associated with Obstructive Hydrocephalus following Radiosurgery for a Cerebral Arteriovenous Malformation: A Case Report and Literature Review. ( 26904328 )
2016
18
Brain Edema after Repeat Gamma Knife Radiosurgery for a Large Arteriovenous Malformation: A Case Report. ( 27574486 )
2016
19
Stomach arteriovenous malformation resected by laparoscopy-assisted surgery: A case report. ( 27117962 )
2016
20
Total temporary occlusion of blood flow for several hours to treat a giant deep arteriovenous malformation: A series of multiple operations to save a young life. ( 27625889 )
2016
21
Amplatzer Vascular Plugs Versus Coils for Embolization of Pulmonary Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia. ( 27150804 )
2016
22
Vascular Integrity in the Pathogenesis of Brain Arteriovenous Malformation. ( 26463919 )
2016
23
Comparative analysis of arteriovenous malformation grading scales in predicting outcomes after stereotactic radiosurgery. ( 27058199 )
2016
24
Pulmonary arteriovenous malformation in chronic thromboembolic pulmonary hypertension. ( 27413264 )
2016
25
Cerebral Arteriovenous Malformation in Wyburn-Mason Syndrome. ( 27112169 )
2016
26
Brain Arteriovenous Malformation Recurrence-Recanalization or Rebirth? ( 27530717 )
2016
27
Salvage pneumonectomy for pulmonary arteriovenous malformation in a 12-year-old boy with brain abscess and hemiparesis: A fatal outcome. ( 27051111 )
2016
28
Delayed presentation of an arteriovenous malformation after cerebellar hemangioblastoma resection-Case report. ( 27086272 )
2016
29
Application of fluorescein sodium videoangiography in surgery for spinal arteriovenous malformation. ( 28049610 )
2016
30
Subsequent haemorrhage in children with untreated brain arteriovenous malformation: Higher risk with unbalanced inflow and outflow angioarchitecture. ( 27900505 )
2016
31
EP10.03: Twins discordant for an arteriovenous malformation between celiac trunk and intrahepatic umbilical vein. ( 27645373 )
2016
32
Management of a large diffuse maxillofacial arteriovenous malformation previously treated with ligation of ipsilateral arterial supply. ( 27540624 )
2016
33
Letter regarding: Absence of skin discoloration after transarterial embolization of a subcutaneous auricular arteriovenous malformation with PHIL. ( 27941133 )
2016
34
Molecular Imaging in Neurovascular Diseases: The Use of Ferumoxytol to Assess Cerebral Aneurysms and Arteriovenous Malformations. ( 27049242 )
2016
35
Arteriovenous malformation of the maxillary sinus: a rare clinical entity. ( 27595923 )
2016
36
RASA1 somatic mutation and variable expressivity in capillary malformation/arteriovenous malformation (CM/AVM) syndrome. ( 26969842 )
2016
37
Arteriovenous malformation of the inferior mesenteric artery presenting as ischemic colitis. ( 27138349 )
2016
38
Reply to Letter Regarding "Amplatzer Vascular Plugs Versus Coils for Embolization of Pulmonary Arteriovenous Malformations in Patients with Hereditary Hemorrhagic Telangiectasia". ( 27506772 )
2016
39
In Reply: Lower Risk of Intracranial Arteriovenous Malformation Hemorrhage in Patients With Hereditary Hemorrhagic Telangiectasia. ( 27580480 )
2016
40
Treatment of a giant arteriovenous malformation associated with intracranial aneurysm rupture during pregnancy: A case report. ( 27588055 )
2016
41
Comparing monomodality treatments of low-grade intracranial arteriovenous malformation at Hospital Kuala Lumpur between 2008 and 2011: A retrospective study. ( 26889274 )
2016
42
Ruptured Aneurysm Associated with Bronchial Arteriovenous Malformation. ( 27041178 )
2016
43
Sex-dichotomous effects of NOS1AP promoter DNA methylation on intracranial aneurysm and brain arteriovenous malformation. ( 27080431 )
2016
44
Transcatheter embolization of pancreatic arteriovenous malformation associated with recurrent acute pancreatitis. ( 27081231 )
2016
45
Acute Hemarthrosis of the Knee Caused by Arteriovenous Malformation. ( 27231206 )
2016
46
Pulmonary hypertension associated with Parkes-Weber syndrome (a rare congenital arteriovenous malformation). ( 27707981 )
2016
47
Spinal Glomus Arteriovenous Malformation Manifesting with a Subarachnoid Hemorrhage. ( 27923749 )
2016
48
Hereditary hemorrhagic telangiectasia patient presenting with brain abscess due to silent pulmonary arteriovenous malformation. ( 28292107 )
2016
49
RETINAL ARTERIOVENOUS MALFORMATION. ( 27533644 )
2016
50
Regression of a Pulmonary Arteriovenous Malformation after Acute Interstitial Nephritis. ( 27250058 )
2016

Variations for Arteriovenous Malformation

Expression for Arteriovenous Malformation

Search GEO for disease gene expression data for Arteriovenous Malformation.

Pathways for Arteriovenous Malformation

Pathways related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

(show all 41)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 BMPR2 IL6 MMP3 MMP9 PTEN RASA1
2
Show member pathways
13.71 ACVRL1 ANGPT2 BMPR2 IL6 PTEN RASA1
3
Show member pathways
13.54 ACVRL1 ANGPT2 BMPR2 IL6 TEK TGFB1
4
Show member pathways
13.3 MMP3 MMP9 PTEN TGFB1 THBS1 VEGFA
5
Show member pathways
13.27 ACVRL1 ANGPT2 BMPR2 IL6 PTEN TEK
6
Show member pathways
13.19 IL6 MMP3 MMP9 RASA1 TEK TGFB1
7
Show member pathways
13.1 ACVRL1 ANGPT2 BMPR2 IL6 PTEN TEK
8
Show member pathways
12.61 ANGPT2 RASA1 TEK THBS1 VEGFA
9 12.5 IL6 MMP9 PTEN TGFB1 VEGFA
10
Show member pathways
12.48 ANGPT2 IL6 RASA1 TEK
11 12.33 BMPR2 MMP9 PTEN THBS1 VEGFA
12 12.27 ANGPT2 IL6 PTEN TEK THBS1 VEGFA
13 12.21 MMP9 TGFB1 THBS1 VEGFA
14 12.04 IL6 MMP9 TGFB1 VEGFA
15
Show member pathways
12.03 IL6 PTEN TGFB1
16 12 BMPR2 MMP9 VEGFA
17
Show member pathways
11.99 IL6 PTEN TGFB1
18 11.98 IL6 TGFB1 VEGFA
19 11.92 IL6 MMP9 TGFB1
20 11.86 IL6 MMP3 MMP9
21 11.82 ACVRL1 ENG TGFB1
22 11.81 IL6 TGFB1 VEGFA
23 11.79 ENG IL6 TGFB1
24 11.73 BMPR2 TGFB1 THBS1
25 11.73 IL6 PTEN TGFB1 THBS1
26 11.66 MMP9 THBS1 VEGFA
27 11.66 ANGPT2 IL6 TEK VEGFA
28 11.61 MMP9 TGFB1 VEGFA
29 11.61 IL6 MMP3 MMP9 TGFB1 VEGFA
30 11.59 IL6 MMP9 TGFB1
31 11.54 ENG TGFB1 THBS1
32 11.46 IL6 TGFB1 VEGFA
33 11.42 IL6 TGFB1 THBS1
34
Show member pathways
11.42 IL6 MMP3 MMP9 VEGFA
35 11.4 IL6 TGFB1 VEGFA
36 11.31 IL6 MMP3 TEK TGFB1 VEGFA
37 11.11 ANGPT2 ENG MMP3 MMP9 TEK TGFB1
38
Show member pathways
11.08 ACVRL1 BMPR2 TGFB1
39 10.99 MMP9 TEK VEGFA
40 10.9 MMP9 TGFB1
41 10.83 IL6 TGFB1

GO Terms for Arteriovenous Malformation

Cellular components related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 ANGPT2 IL6 MMP3 MMP9 PTEN TEK
2 proteinaceous extracellular matrix GO:0005578 9.71 MMP3 MMP9 TGFB1 VEGFA
3 extracellular matrix GO:0031012 9.67 MMP3 MMP9 TGFB1 THBS1
4 extracellular space GO:0005615 9.61 ANGPT2 BMPR2 ENG IL6 MMP3 MMP9
5 secretory granule GO:0030141 9.5 TGFB1 THBS1 VEGFA
6 platelet alpha granule lumen GO:0031093 9.43 TGFB1 THBS1 VEGFA
7 cell surface GO:0009986 9.17 ACVRL1 BMPR2 ENG TEK TGFB1 THBS1

Biological processes related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

(show top 50) (show all 70)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.99 ENG IL6 PTEN TGFB1 VEGFA
2 heart development GO:0007507 9.97 ENG PTEN TEK TGFB1
3 response to drug GO:0042493 9.97 ENG IL6 PTEN TGFB1 THBS1
4 leukocyte migration GO:0050900 9.95 ANGPT2 MMP9 TEK TGFB1
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.93 IL6 PTEN TEK TGFB1
6 positive regulation of cell migration GO:0030335 9.92 MMP9 TGFB1 THBS1 VEGFA
7 regulation of cell shape GO:0008360 9.91 IL6 RASA1 VEGFA
8 platelet degranulation GO:0002576 9.9 TGFB1 THBS1 VEGFA
9 negative regulation of cell growth GO:0030308 9.9 ACVRL1 BMPR2 TGFB1
10 negative regulation of cell migration GO:0030336 9.89 ACVRL1 ENG PTEN
11 response to organic substance GO:0010033 9.88 PTEN TEK TGFB1
12 response to organic cyclic compound GO:0014070 9.88 ANGPT2 IL6 PTEN TGFB1
13 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.87 IL6 TGFB1 VEGFA
14 negative regulation of apoptotic process GO:0043066 9.87 IL6 MMP9 PTEN RASA1 TEK THBS1
15 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 IL6 TGFB1 VEGFA
16 response to mechanical stimulus GO:0009612 9.85 ANGPT2 IL6 THBS1
17 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 9.85 IL6 THBS1 VEGFA
18 positive regulation of epithelial cell proliferation GO:0050679 9.84 IL6 TGFB1 VEGFA
19 BMP signaling pathway GO:0030509 9.84 ACVRL1 BMPR2 ENG TGFB1
20 negative regulation of angiogenesis GO:0016525 9.83 ANGPT2 TEK THBS1
21 positive regulation of protein kinase B signaling GO:0051897 9.83 IL6 TEK TGFB1 THBS1
22 positive regulation of protein phosphorylation GO:0001934 9.83 ENG MMP9 TEK TGFB1 VEGFA
23 cellular response to growth factor stimulus GO:0071363 9.82 ANGPT2 TGFB1 THBS1
24 response to glucose GO:0009749 9.8 ANGPT2 PTEN TGFB1 THBS1
25 positive regulation of endothelial cell proliferation GO:0001938 9.78 ACVRL1 BMPR2 TEK VEGFA
26 positive regulation of BMP signaling pathway GO:0030513 9.77 ACVRL1 BMPR2 ENG
27 vasculogenesis GO:0001570 9.76 ENG RASA1 TGFB1 VEGFA
28 positive regulation of focal adhesion assembly GO:0051894 9.74 TEK VEGFA
29 outflow tract septum morphogenesis GO:0003148 9.74 BMPR2 ENG
30 cardiac muscle tissue development GO:0048738 9.74 BMPR2 PTEN
31 artery morphogenesis GO:0048844 9.74 ENG VEGFA
32 blood vessel morphogenesis GO:0048514 9.74 ACVRL1 ANGPT2 RASA1
33 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.73 ACVRL1 BMPR2
34 regulation of transforming growth factor beta receptor signaling pathway GO:0017015 9.73 ENG TGFB1
35 positive regulation of branching involved in ureteric bud morphogenesis GO:0090190 9.73 TGFB1 VEGFA
36 negative regulation of endothelial cell migration GO:0010596 9.73 ACVRL1 THBS1
37 endothelial cell proliferation GO:0001935 9.73 BMPR2 TEK
38 sprouting angiogenesis GO:0002040 9.73 ENG TEK THBS1
39 angiogenesis GO:0001525 9.73 ACVRL1 ANGPT2 ENG PTEN TEK VEGFA
40 macrophage differentiation GO:0030225 9.72 MMP9 VEGFA
41 activin receptor signaling pathway GO:0032924 9.72 ACVRL1 BMPR2
42 endocardial cushion morphogenesis GO:0003203 9.72 ACVRL1 ENG
43 negative regulation of cell-matrix adhesion GO:0001953 9.72 RASA1 THBS1
44 positive regulation of blood vessel endothelial cell migration GO:0043536 9.72 TGFB1 THBS1 VEGFA
45 negative regulation of DNA biosynthetic process GO:2000279 9.71 ACVRL1 BMPR2
46 lymphangiogenesis GO:0001946 9.71 ACVRL1 BMPR2
47 positive regulation of fibroblast migration GO:0010763 9.71 TGFB1 THBS1
48 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.71 ACVRL1 BMPR2 ENG TGFB1
49 positive regulation of chemotaxis GO:0050921 9.7 TGFB1 THBS1
50 negative regulation of phagocytosis GO:0050765 9.7 PTEN TGFB1

Molecular functions related to Arteriovenous Malformation according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.97 ACVRL1 ANGPT2 BMPR2 ENG IL6 MMP3
2 platelet-derived growth factor receptor binding GO:0005161 9.48 PTEN VEGFA
3 transmembrane receptor protein serine/threonine kinase activity GO:0004675 9.46 ACVRL1 BMPR2
4 activin binding GO:0048185 9.43 ACVRL1 ENG
5 glycoprotein binding GO:0001948 9.43 RASA1 TGFB1 THBS1
6 type I transforming growth factor beta receptor binding GO:0034713 9.4 ENG TGFB1
7 BMP binding GO:0036122 9.37 BMPR2 ENG
8 type II transforming growth factor beta receptor binding GO:0005114 9.32 ENG TGFB1
9 BMP receptor activity GO:0098821 8.96 ACVRL1 BMPR2
10 transforming growth factor beta binding GO:0050431 8.8 ACVRL1 ENG THBS1

Sources for Arteriovenous Malformation

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
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37 KEGG
38 LifeMap
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42 MeSH
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44 MGI
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48 NDF-RT
51 NINDS
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54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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