MCID: ART022
MIFTS: 75

Arthritis malady

Summaries for Arthritis

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
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MedlinePlus:33 If you feel pain and stiffness in your body or have trouble moving around, you might have arthritis. most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. over time, a swollen joint can become severely damaged. some kinds of arthritis can also cause problems in your organs, such as your eyes or skin. types of arthritis include osteoarthritis is the most common type of arthritis. it's often related to aging or to an injury. autoimmune arthritis happens when your body's immune system attacks healthy cells in your body by mistake. rheumatoid arthritis is the most common form of this kind of arthritis. juvenile rheumatoid arthritis is a form of the disease that happens in children. infectious arthritis is an infection that has spread from another part of the body to the joint. psoriatic arthritis affects people with psoriasis. gout is a painful type of arthritis that happens when too much uric acid builds up in the body. it often starts in the big toe. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and psoriatic arthritis. An important gene associated with Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Collagen biosynthesis and modifying enzymes and Matrix Metalloproteinases. The drugs meclofenamate sodium and salsalate and the compounds vegf and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin over the joint, joint and bone, and related mouse phenotypes are immune system and cardiovascular system.

Disease Ontology:8 A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located in joint and/or redness located in skin over the joint.

CDC:3 Arthritis affects 52.5 million U.S. adults, more than 1 in 5. It is the nation’s most common cause of disability. Learn more about arthritis, the proven ways to manage it and the resources available to public health professionals.

Wikipedia:63 Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint... more...

Aliases & Classifications for Arthritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
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Classifications:



Aliases & Descriptions:

arthritis 8 10 44 33 60
inflammatory joint disease 44 60
inflammatory disorder of joint 8


External Ids:

Disease Ontology8 DOID:848
NCIt39 C2883
MeSH34 D001168
ICD1025 M13.8, M13.9

Related Diseases for Arthritis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Arthritis family:

Transient Arthritis

Diseases related to Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 909)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis32.4SERPINH1, PTPN22, MMP9, MMP1, MMP11, MMP19
2psoriatic arthritis31.7IL1A, MMP3, MMP1, PTPN22
3juvenile rheumatoid arthritis31.6IL6, IL1A, LTA
4osteoarthritis31.3LTA, IL1A, IL6, MMP13, MMP3, MMP2
5psoriasis31.2LTA, IL10, IL1A, IL6, MMP19, PTPN22
6systemic lupus erythematosus31.2SERPINH1, PTPN22, MMP3, IL6, IL10, LTA
7synovitis31.1MMP1, MMP11, MMP8, MMP3, MMP13, IL6
8uveitis30.9IL1A, IL10, LTA
9pneumonia30.8MMP12, MMP8, IL6, IL10
10tuberculosis30.7IL10
11atherosclerosis30.7MMP13, IL6, IL1A, IL10, MMP3, MMP10
12periodontitis30.7MMP9, MMP8, IL1A
13glomerulonephritis30.7SERPINH1
14hepatitis30.7LTA
15dermatitis30.7IL1A
16interstitial lung disease30.6MMP9
17osteoporosis30.6IL6, MMP13, MMP3, MMP8
18leukemia30.6BST1, LTA, IL1A, IL6
19connective tissue disease30.6IL10, IL6, PTPN22
20arthropathy30.6MMP13, MMP3, MMP1
21thyroiditis30.4PTPN22
22myositis30.4IL1A
23vascular disease30.4IL10, IL1A, IL6, MMP3, MMP2
24periodontal disease30.4IL6, MMP3, MMP2, MMP1
25hepatitis c30.4IL10
26asthma30.3IL10, MMP3, MMP8, MMP12, MMP9
27diabetes mellitus30.3IL6, MMP3, MMP9, PTPN22
28obesity30.3MMP3, IL6
29ulcerative colitis30.3LTA, IL10, IL1A, IL6, MMP13, MMP3
30skin disease30.2MMP9, IL6, IL1A
31meningitis30.2MMP9, IL6
32hepatitis b30.2MMP3
33multiple sclerosis30.2LTA, IL10, IL6, MMP8, MMP12, MMP19
34gingivitis30.2MMP1, MMP8, MMP13, IL1A
35bronchiolitis obliterans30.2MMP8
36systemic scleroderma30.2IL1A, MMP3, MMP12, MMP1, PTPN22, SERPINH1
37myeloma30.2MMP8, IL6, LTA
38kawasaki disease30.2MMP9, MMP3
39sarcoma30.2MMP11
40leishmaniasis30.2IL10
41toxic shock syndrome30.2LTA
42inflammatory bowel disease30.2LTA, IL10, IL6, MMP13, MMP3, MMP1
43aggressive periodontitis30.1IL1A, MMP8, MMP1
44celiac disease30.1MMP12, PTPN22
45hypertension30.1MMP9
46pulmonary fibrosis30.1MMP13, MMP2, MMP1, MMP9, SERPINH1
47pancreatitis30.1IL6, IL10
48sarcoidosis30.1IL1A, LTA
49keratitis30.1MMP9, MMP2
50lymphopenia30.1IL6, PTPN22, IL10

Graphical network of the top 20 diseases related to Arthritis:



Diseases related to arthritis

Clinical Features for Arthritis

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Drugs & Therapeutics for Arthritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Arthritis

Drug clinical trials:

Search ClinicalTrials for Arthritis

Search NIH Clinical Center for Arthritis

Search CenterWatch for Arthritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Arthritis

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Anatomical Context for Arthritis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Arthritis:

32
Bone, T cells, Monocytes, Endothelial, Skin, B cells, Lung, Testes, Bone marrow, Eye, Heart, Myeloid, Liver, Thyroid, Pituitary, Whole blood, Kidney, Breast, Lymph node, Spleen, Spinal cord, Tonsil, Colon, Nk cells, Salivary gland, Brain, Tongue, Thymus, Small intestine, Cervix, Prostate, Placenta, Retina, Smooth muscle, Skeletal muscle

FMA organs/tissues related to Arthritis:

14
Skin over the joint, Joint

Animal Models for Arthritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.1PTPN22, MMP9, MMP12, MMP8, MMP2, MMP10
2MP:000538512.5SERPINH1, LTA, IL10, IL1A, MMP15, MMP13
3MP:000537812.5LTA, IL10, IL6, MMP15, MMP13, MMP2
4MP:000537612.0MMP13, MMP19, PTPN22, MMP17, LTA, MMP11
5MP:000538811.8SERPINH1, IL6, MMP10, MMP2, MMP9, LTA
6MP:000200611.6MMP9, MMP11, MMP8, IL10, MMP19, IL6
7MP:000539011.5MMP3, LTA, IL6, MMP13, SERPINH1

Publications for Arthritis

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Sources:
50PubMed
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Articles related to Arthritis:

(show top 50)    (show all 11128)
idTitleAuthorsYear
1
Novel Phosphoinositide 3-Kinase I',I^ Inhibitor: Potent Anti-Inflammatory Effects and Joint Protection in Models of Rheumatoid Arthritis. (24244039)
2014
2
Abatacept inhibits radiographic progression in patients with rheumatoid arthritis: a retrospective analysis of 6 months of abatacept treatment in routine clinical practice. The ALTAIR study. (24261758)
2014
3
Predicting the severity of joint damage in rheumatoid arthritis; the contribution of genetic factors. (24431388)
2014
4
A genetic variant in granzyme B is associated with progression of joint destruction in rheumatoid arthritis. (23440692)
2013
5
Beyond anti-TNF-I+ agents in psoriatic arthritis. (23730881)
2013
6
Safe surgical technique: reconstruction of the sternoclavicular joint for posttraumatic arthritis after posterior sternoclavicular dislocation. (24378156)
2013
7
Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease. (23127549)
2013
8
Neutrophilic cholangitis in psoriasis vulgaris and psoriatic arthritis. (22971251)
2013
9
Septic arthritis of the elbow in a child due to Pseudomonas aeruginosa: a case report. (24248431)
2013
10
Psoriatic arthritis: treatment strategies using biologic agents. (22690388)
2012
11
Hepatic steatosis, carotid plaques and achieving MDA in psoriatic arthritis patients starting TNF-I+ blockers treatment: a prospective study. (23036698)
2012
12
Anti-TNFI+ therapy may lead to blood pressure reductions through improved endothelium-dependent microvascular function in patients with rheumatoid arthritis. (21525886)
2011
13
Amyloid A amyloidosis secondary to rheumatoid arthritis: pathophysiology and treatments. (22011672)
2011
14
Lyme disease and the orthopaedic implications of lyme arthritis. (21292932)
2011
15
Folate pathway enzyme gene polymorphisms and the efficacy and toxicity of methotrexate in psoriatic arthritis. (20472929)
2010
16
Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis. (19690516)
2009
17
Variants in TNFAIP3, STAT4, and C12orf30 loci associated with multiple autoimmune diseases are also associated with juvenile idiopathic arthritis. (19565500)
2009
18
Atherosclerosis in rheumatoid arthritis and systemic lupus erythematosus. (18607179)
2008
19
Disseminated histoplasmosis associated with the treatment of rheumatoid arthritis with anticytokine therapy. (18936512)
2008
20
Juvenile psoriatic arthritis carrying familial Mediterranean fever gene mutations in a 14-year-old Turkish girl. (17408446)
2007
21
Thioredoxin protects against joint destruction in a murine arthritis model. (16678011)
2006
22
Oncostatin M induces angiogenesis and cartilage degradation in rheumatoid arthritis synovial tissue and human cartilage cocultures. (17009243)
2006
23
A selective p38 alpha mitogen-activated protein kinase inhibitor reverses cartilage and bone destruction in mice with collagen-induced arthritis. (16597712)
2006
24
Polymorphisms within interleukin 15 are associated with juvenile idiopathic arthritis. (16762172)
2006
25
Does systemic-onset juvenile idiopathic arthritis belong under juvenile idiopathic arthritis? (15956091)
2005
26
Cataract surgery and intraocular lens implantation in children with juvenile rheumatoid arthritis associated uveitis. (16193679)
2005
27
Expression of IL-17 homologs and their receptors in the synovial cells of rheumatoid arthritis patients. (15879699)
2005
28
Cleavage of p53-vimentin complex enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis of rheumatoid arthritis synovial fibroblasts. (16127151)
2005
29
The effect of interferon-gamma in collagen-induced arthritis in mice shows a mechanism of expanding Mac-1+ blood cells during its pathogenesis]. (16089294)
2005
30
Assessing the cost-effectiveness of COX-2 specific inhibitors for arthritis in the Veterans Health Administration. (15881475)
2005
31
Interleukin-1 receptor antagonist gene polymorphism and rheumatoid arthritis. (14872281)
2004
32
Interstitial granulomatous dermatitis with arthritis. (15257555)
2004
33
Detection of antibodies against glucose 6-phosphate isomerase in synovial fluid of rheumatoid arthritis using surface plasmon resonance (BIAcore). (14508072)
2003
34
Altered levels of soluble adhesion molecules in patients with rheumatoid arthritis complicated by peripheral neuropathy. (11824972)
2002
35
TNF involvement and anti-TNF therapy of reactive and unclassified arthritis. (12463463)
2002
36
Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8. (11178119)
2001
37
IL-1B and IL-1Ra gene polymorphisms and disease severity in rheumatoid arthritis: interaction with their plasma levels. (11477478)
2001
38
Gastroduodenal lesions in children with juvenile rheumatoid arthritis. (10370653)
1999
39
Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. (10510398)
1999
40
The effect of methotrexate on the temporomandibular joint in polyarticular juvenile rheumatoid arthritis patients. (19078423)
1999
41
MPO antibody-positive vasculitis in a patient with psoriatic arthritis and gold-induced membranous glomerulonephritis. (9719174)
1998
42
Circulating levels of interleukin 10 and other cytokines in rheumatoid arthritis treated with cyclosporin A or combination therapy. (9779838)
1998
43
Outcome and predictive factors in juvenile rheumatoid arthritis and juvenile spondyloarthropathy. (9489836)
1998
44
Combined elevation of IgM and IgA rheumatoid factor has high diagnostic specificity for rheumatoid arthritis. (9833253)
1998
45
Destructive corneal and scleral disease associated with rheumatoid arthritis. Medical and surgical management. (7671613)
1995
46
Generalized secondary amyloidosis in rheumatoid arthritis. (1365773)
1992
47
"Yellow nail syndrome" and rheumatoid arthritis. (1820660)
1991
48
Relapsing polychondritis syndrome associated with pustular psoriasis, spondylitis and arthritis mutilans. (3572919)
1987
49
A study of the response of the leukopenia of rheumatoid arthritis to gold salt therapy. (6795350)
1981
50
A case of insulin autoimmune syndrome associated with small insulinomas and rheumatoid arthritis. (6266819)
1980

Genetic Variations for Arthritis

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Expression for genes affiliated with Arthritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthritis

Search GEO for disease gene expression data for Arthritis.

Pathways for genes affiliated with Arthritis

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Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems
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Pathways related to Arthritis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
13.2MMP10, MMP2, MMP8, MMP12, MMP19, MMP11
2
Hide members
13.0MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
3
Hide members
12.8MMP10, MMP3, MMP13, IL6, MMP2, MMP8
4
Cell adhesion ECM remodeling
Hide members
12.8MMP10, MMP2, MMP8, MMP12, MMP19, MMP17
5
Hide members
12.6MMP2, MMP10, MMP3, MMP13, MMP8, MMP12
6
Hide members
12.6MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
711.7IL6, MMP2, MMP12, MMP11, MMP1, MMP9
811.3IL6, MMP2, MMP1, MMP9
911.3LTA, IL6, MMP3, MMP9
1011.3IL6, IL1A, IL10, LTA
11
Hide members
11.3IL6, IL1A, IL10, LTA
12
Cell adhesion Cell-matrix glycoconjugates
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11.1MMP3, MMP1, MMP9
13
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.1MMP1, MMP3, MMP13
1411.1MMP13, MMP9, SERPINH1
1511.1MMP9, MMP2, IL6
1611.1MMP9, MMP2, IL6
17
Hide members
11.1MMP2, MMP3, MMP13
1811.1MMP13, MMP2, MMP9
1911.1IL6, IL1A, IL10
2011.1IL10, IL1A, IL6
21
Hide members
11.1LTA, IL10, IL6
22
Hide members
10.9PTPN22, LTA

Compounds for genes affiliated with Arthritis

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Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
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Compounds related to Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1vegf4413.9SERPINH1, MMP9, MMP1, LTA, IL10, IL1A
2calcium44 49 11 2416.8MMP9, MMP13, MMP15, MMP8, BST1, MMP3
3gi 254023x5913.5MMP10, MMP2, MMP8, MMP12, MMP19, MMP11
4gm 60015913.5MMP10, MMP2, MMP8, MMP12, MMP11, MMP17
5marimastat44 59 1115.5MMP11, MMP19, MMP15, MMP13, MMP3, MMP10
6batimastat44 59 1115.5MMP1, MMP17, MMP11, MMP19, MMP12, MMP8
7uk 3833675913.5MMP15, MMP1, MMP17, MMP13, MMP3, MMP10
8retinoic acid44 2414.2LTA, BST1, MMP8, MMP9, MMP11, MMP1
9serine4412.9MMP3, MMP1, MMP12, LTA, IL1A, MMP13
1012-o-tetradecanoylphorbol 13-acetate4412.8MMP1, LTA, IL1A, MMP13, MMP3, MMP10
11genistein44 28 59 2 11 2417.8MMP8, MMP2, MMP3, IL6, IL1A, MMP12
12tgf beta14412.6MMP13, IL6, MMP3, MMP2, MMP1, MMP9
13hyaluronic acid44 2413.6IL1A, LTA, IL6, MMP13, MMP2, MMP1
14sb 20358044 5913.6IL1A, MMP1, MMP2, MMP3, MMP9, MMP13
15paraffin4412.5MMP3, MMP1, MMP9, MMP11, IL10, LTA
16hydroxamate4412.4MMP9, MMP1, MMP12, MMP8, MMP2, MMP3
17progesterone44 59 28 11 2416.4LTA, IL1A, MMP2, MMP11, MMP15, MMP1
18prednisolone44 28 1114.4IL6, MMP1, MMP2, MMP3, MMP13, IL10
19herbimycin a44 5913.3IL6, MMP13, MMP1, LTA, MMP2, MMP9
20curcumin4412.3IL6, MMP13, MMP3, MMP1, MMP9, IL1A
21etanercept44 49 1114.2MMP1, LTA, MMP12, MMP3, IL6, IL10
22doxycycline44 1113.1MMP8, MMP1, MMP9, MMP3, MMP13, MMP2
23tetracycline44 1113.1MMP9, MMP1, MMP8, MMP2, MMP13, IL1A
24oligonucleotide4412.1MMP1, MMP11, MMP12, SERPINH1, MMP10, MMP13
25glycosaminoglycan4412.1MMP13, IL1A, MMP3, MMP8, MMP1, MMP9
26lactate4412.0MMP9, IL6, MMP3, MMP2, MMP8, MMP1
27clodronate44 49 1113.9MMP13, IL10, MMP1, MMP8, IL6
28alendronate44 49 1113.9MMP8, MMP2, MMP13, MMP1, MMP3
29dexamethasone44 49 28 1114.8MMP12, LTA, MMP9, IL6, MMP13
30infliximab44 49 1113.8LTA, IL10, IL6, MMP3, MMP1
31ibuprofen44 28 49 11 2415.8MMP1, MMP2, IL6, IL10, MMP3
32(4-aminophenyl)mercuric acetate4411.8MMP8, MMP10, MMP13, MMP3
33methotrexate44 49 1113.7MMP1, MMP3, MMP2, IL6, IL10, MMP9
34matrigel4411.7MMP13, MMP3, MMP10, MMP1
35cyclosporin a44 28 5913.7SERPINH1, MMP8, MMP1, LTA
36pdtc4411.7IL1A, MMP9, MMP1, MMP2, IL6
37ilomastat4411.7MMP2, MMP9, MMP1, MMP3
38latanoprost44 1112.6MMP1, MMP3, MMP2, MMP9
39pravastatin44 49 28 11 2415.6IL1A, MMP3, MMP1, IL6, MMP2
40aprotinin44 1112.5MMP2, MMP13, MMP1
41rantes4411.5IL6, IL1A, LTA
42pentoxifylline44 1112.5MMP2, LTA, MMP1
43cgs-27023a4411.4MMP2, MMP1, MMP9
44prostaglandin4411.3MMP1, MMP3, IL1A
45pge24411.3MMP9, MMP2
46thps4411.3MMP13, MMP2, MMP1
47n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1112.2MMP3, MMP10, MMP12
48ivig4411.1IL1A
49cycloheximide4411.0LTA
50zoledronic acid4411.0MMP9, MMP1, IL6, MMP2

GO Terms for genes affiliated with Arthritis

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16Gene Ontology
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Cellular components related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557613.0MMP1, MMP11, MMP19, MMP12, MMP8, MMP2
2proteinaceous extracellular matrixGO:00557812.7MMP12, MMP9, MMP1, MMP17, MMP11, MMP19
3extracellular spaceGO:00561512.5MMP9, IL10, IL1A, IL6, MMP13, MMP3

Biological processes related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019813.0MMP3, MMP10, MMP2, MMP8, MMP12, MMP19
2collagen catabolic processGO:03057412.9MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
3proteolysisGO:00650812.7MMP13, MMP3, MMP10, MMP2, MMP8, MMP12
4extracellular matrix disassemblyGO:02261712.7MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
5humoral immune responseGO:00695911.1BST1, LTA, IL6

Molecular functions related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422213.0MMP9, MMP15, MMP13, MMP3, MMP10, MMP2
2zinc ion bindingGO:00827012.9MMP2, MMP10, MMP3, MMP13, MMP15, MMP8
3calcium ion bindingGO:00550912.3MMP15, MMP13, MMP3, MMP10, MMP8, MMP12
4cytokine activityGO:00512511.3IL6, IL1A, IL10, LTA

Products for genes affiliated with Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arthritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet