Arthritis malady

MedlinePlus: If you feel pain and stiffness in your body or have trouble moving around, you might have arthritis. most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. over time, a swollen joint can become severely damaged. some kinds of arthritis can also cause problems in your organs, such as your eyes or skin. one type of arthritis, osteoarthritis, is often related to aging or to an injury. other types occur when your immune system, which normally protects your body from infection, attacks your body's own tissues. rheumatoid arthritis is the most common form of this kind of arthritis. juvenile rheumatoid arthritis is a form of the disease that happens in children. infectious arthritis is an infection that has spread from another part of the body to the joint. nih: national institute of arthritis and musculoskeletal and skin diseases²³

MalaCards: Arthritis, also known as inflammatory joint disease, is related to carcinoma and leukemia. An important gene associated with Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Antioxidant Action of Vitamin-C and JAK-STAT Pathway. The drugs meclofenamate sodium and devils claw and the compounds serine and vegf have been mentioned in the context of this disorder. Affiliated tissues include joint, skin over the joint and bone marrow, and related mouse phenotypes are homeostasis/metabolism and cellular.

Disease Ontology: A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located in joint and/or redness located in skin over the joint.⁶

CDC: Arthritis is the most common cause of disability in the United States, limiting the activities of nearly 21 million adults. The CDC Arthritis Program is working to improve the quality of life for people affected by arthritis and other rheumatic conditions by working with states and other partners to increase awareness about appropriate arthritis self management activities and expanding the reach of programs proven to improve the quality of life for people with arthritis. See Arthritis Spotlights on Science >>²

Wikipedia: Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint...⁴⁴ more...

Aliases & Descriptions:

arthritis 6 17 8 32 23 43 inflammatory joint disease 32 43 inflammatory disorder of joint 6

inflammatory disorder 43

Diseases related to arthritis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 960)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	268.4	PIK3CD, PIK3CG, PIN1, LRP1, LRP2, LRP5
2	leukemia	245.1	PIK3CD, PIBF1, PIK3CG, PIN1, LRP1, LRP5
3	melanoma	187.1	PIK3CD, PIK3CG, LRP1, KL, KLF5, PDCD1
4	neuronitis	182.8	ZNF395, PIK3CD, PIK3CG, PIN1, LRP1, LRP2
5	lupus erythematosus	178.9	ZNF311, PIK3CD, PIK3CG, LRP2, SH2B3, PDCD1
6	thyroiditis	170.5	PIK3CG, PIN1, LRP1, LRP2, RFC1, PDCD5
7	fibrosis	158.5	PIK3CG, PIN1, LRP1, KL, NCF1, PDE4A
8	atherosclerosis	154.7	PIK3CG, LRP1, LRP2, LRP5, KL, KLF5
9	cervicitis	148.2	PIK3CG, PIN1, KL, RFC1, PDCD1, PDCD1LG2
10	hypoxia	145.2	PIK3CD, PIK3CG, LRP1, LRP5, KLF5, PDE4A
11	tuberculosis	142.4	PIK3CG, SH2D1A, NCF1, PDCD1, PDCD1LG2, RELA
12	psoriasis	138.2	ZNF750, LRP1, RFC1, PDE4A, RETN, CNR1
13	osteoarthritis	136.0	PIK3CG, LRP5, KL, PDE4A, RELA, RETN
14	prostatitis	135.6	ZNF750, PIK3CD, PIBF1, PIK3CG, PIN1, LRP1
15	diabetes mellitus	135.0	PIK3CD, PIK3CG, LRP5, SH2B3, PDCD1, PDCD1LG2
16	cerebritis	134.0	PIK3CG, LRP1, LRP2, NDEL1, NCF1, PDE4A
17	cholesterol	133.7	PIK3CD, PIK3CG, LRP1, LRP2, LRP5, KL
18	gonococcal synovitis	129.6	PIK3CG, LRP1, PDCD1, PDE4A, RECK, REL
19	sarcoma	129.0	ZNF395, PIK3CD, PIK3CG, PDE4A, RECK, RELA
20	pancreatitis	125.8	PIK3CD, PIK3CG, PIN1, LRP1, LRP2, LRP5
21	retinitis	124.6	PIK3CG, LRP1, LRP2, LRP5, PDE4A, CNBP
22	hypertension	124.2	PIK3CG, LRP1, LRP5, SH2B3, KL, KLF5
23	obesity	122.9	PIK3CG, LRP1, LRP5, RECK, RELA, RETN
24	pneumonia	121.8	KL, PDE4A, RELA, CNDP2, VTN, SFTPD
25	nephropathy	121.5	LRP1, LRP2, PDCD1, RELA, RETN, CNDP2
26	peritonitis	118.7	PIBF1, LRP1, RELA, RELB, CNTF, KIT
27	myocardial infarction	118.2	PIK3CG, LRP1, SH2B3, PDCD1, PDE4A, RECK
28	ischemia	117.5	PIK3CG, PDE4A, RELA, RETN, CNR1, CNR2
29	adenocarcinoma	114.0	PIK3CG, PIN1, LRP1, PDCD5, RECK, RELA
30	pulmonary disease	110.3	PIK3CG, PIN1, LRP5, PDE4A, RETN, VWF
31	colorectal cancer	108.6	PIK3CD, PIK3CG, PIN1, LRP2, LRP5, KL
32	anemia	107.9	SH2D1A, PDCD1, RELA, KIT, KITLG, VWF
33	dermatitis	106.0	ZNF750, PDE4A, REL, RELA, RELB, CNR1
34	hepatocellular carcinoma	105.7	PIK3CD, PIK3CG, PIN1, KL, PDCD1, PDCD1LG2
35	influenza	105.3	PIK3CD, PIK3CG, RECK, RELA, KIR2DL1, KIR2DL2
36	schizophrenia	101.5	PIK3CG, LRP2, KLF12, KLF5, NDEL1, PDE4A
37	cystic fibrosis	100.7	PIK3CG, PDE4A, RECK, VWF, SFTPD, PCNA
38	gingivitis	99.6	PIK3CG, CNR1, CNR2, PCNA, BTK, SELE
39	ovarian cancer	98.3	PIK3CD, PIK3CG, LRP1, NCF1, PDCD1, RECK
40	gastric cancer	96.9	PIK3CG, PIN1, KLF12, KLF5, RFC1, RECK
41	systemic lupus erythematosus	96.8	LRP2, PDCD1, RECK, CNBP, VWF, VTN
42	squamous cell carcinoma	94.3	PIN1, RECK, RELA, VTN, RDX, PCNA
43	insulin resistance	93.9	PIK3CG, LRP1, RELA, RETN, CNBP, CNR1
44	blindness	89.6	PIBF1, PIK3CG, LRP5, PDE4A, CNBP, CNR1
45	myeloma	89.6	PIK3CG, LRP1, LRP2, LRP5, PDCD5, PDE4A
46	alzheimer's disease	88.6	PIK3CD, PIK3CG, PIN1, LRP1, LRP2, RFC1
47	colon cancer	86.1	PIK3CG, KLF5, RFC1, PDE4A, RECK, RELA
48	esophagitis	84.8	PIK3CG, PIN1, KLF5, PDCD1LG2, PDCD5, PDE4A
49	glomerulonephritis	84.0	LRP1, LRP2, KIT, KITLG, VWF, VTN
50	herpes simplex	84.0	PILRA, PIK3CG, RECK, CNTN2, PCNA, GC

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 devils claw, meclofenamate, meclofenamate sodium, salsalate

Cell-based therapeutics:

MalaCards organs/tissues related to arthritis:

²²

FMA organs/tissues related to arthritis:

¹¹

MGI Mouse Phenotypes related to arthritis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism phenotype	MP:0005376	105.4	PIK3CD, PIK3CG, LRP1, LRP2, LRP5, KL
2	cellular phenotype	MP:0005384	101.3	PIK3CD, PIK3CG, PIN1, LRP2, LRP5, SH2B3
3	mortality/aging	MP:0010768	89.3	LRP1, LRP5, KL, KLF5, NDEL1, NCF1C
4	cardiovascular system phenotype	MP:0005385	73.2	PIK3CD, PIK3CG, LRP1, LRP5, KL, KLF5
5	growth/size phenotype	MP:0005378	70.9	PIK3CG, PIN1, LRP1, LRP2, KL, KLF5
6	immune system phenotype	MP:0005387	69.4	PIK3CD, LRP1, LRP5, SH2D1A, SH2D2A, KL
7	hematopoietic system phenotype	MP:0005397	62.0	SH2B3, SH2D1A, SH2D2A, PDCD1, PDCD1LG2, CNTF
8	behavior/neurological phenotype	MP:0005386	54.7	LRP1, LRP2, LRP5, KL, NCF1C, RELB
9	nervous system phenotype	MP:0003631	53.8	LRP1, LRP5, KL, NDEL1, NCF1C, PDCD1
10	normal phenotype	MP:0002873	49.0	LRP1, LRP5, KLF5, RELA, VTCN1, VTN
11	skeleton phenotype	MP:0005390	45.6	PIK3CD, PIK3CG, LRP1, LRP2, NCF1C, RECK
12	integument phenotype	MP:0010771	44.7	PIK3CG, PIN1, KL, NCF1C, RECK, REL
13	tumorigenesis	MP:0002006	43.4	PDCD1LG2, KIT, KITLG, BTK, RB1, RBPJ
14	digestive/alimentary phenotype	MP:0005381	42.6	LRP2, KL, KLF5, REL, RELB, RELN
15	muscle phenotype	MP:0005369	42.1	PIK3CG, LRP1, KL, KLF5, NCF1C, PDCD1
16	vision/eye phenotype	MP:0005391	39.8	PIN1, LRP2, LRP5, PDCD1, RELA, RELN
17	liver/biliary system phenotype	MP:0005370	32.9	LRP5, NCF1C, RECK, REL, RELB, RETN
18	renal/urinary system phenotype	MP:0005367	32.9	LRP2, KL, PDCD1, KIT, RBPJ, SELP
19	no phenotypic analysis	MP:0003012	32.0	PIK3CD, LRP2, PDCD1LG2, CNR1, SFRP1, PCNA
20	embryogenesis phenotype	MP:0005380	32.0	LRP5, KLF5, NDEL1, RECK, REL, CNBP
21	limbs/digits/tail phenotype	MP:0005371	29.6	LRP5, KL, RECK, RELA, RELB, KIT
22	reproductive system phenotype	MP:0005389	29.4	VIP, VEGFA, VDR, BMP2, BMP7, RAG2
23	adipose tissue phenotype	MP:0005375	28.6	LRP1, KL, RETN, CNR1, SFRP1, RB1
24	respiratory system phenotype	MP:0005388	27.9	LRP2, KL, KLF5, NCF1C, REL, RELB
25	hearing/vestibular/ear phenotype	MP:0005377	23.6	LRP2, KIT, KITLG, RDX, RB1, NAGLU
26	craniofacial phenotype	MP:0005382	23.3	LRP2, LRP5, CNBP, KIT, KITLG, NAGLU
27	endocrine/exocrine gland phenotype	MP:0005379	23.0	LRP2, LRP5, KL, KLF5, NCF1C, RELB
28	other phenotype	MP:0005395	18.9	SH2B3, KL, RECK, RELB, CNR1, SERPINH1
29	pigmentation phenotype	MP:0001186	16.8	LRP5, KIT, KITLG, RB1, RBPJ, SEMA3C

Articles related to arthritis:

(show top 50)    (show all 5861)

id	Title	Authors	Year	Affiliating Genes
1	Subtype specific genetic associations for juvenile id iopathic arthritis: ERAP1 with the enthesitis related arthritis subtype and IL2 3R with juvenile psoriatic arthritis. (21281511)	Hinks A.... Thomson W.	2011	ERAP1, IL23R
2	Predicting arthritis outcomes--what can be learned fr om the Leiden Early Arthritis Clinic? (20639266)	de Rooy D.P.... van der Helm-van Mil A.H.	2011	HLA-DRB1
3	Golimumab: A novel anti-TNF-alpha human monoclonal an tibody for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis . (20200692)	Campas-Moya C.	2010	TNF
4	The role of rheumatoid arthritis genetic susceptibili ty markers in the prediction of erosive disease in patients with early inflamma tory polyarthritis: results from the Norfolk Arthritis Register. (20219786)	Plant D.... Barton A.	2010	PRKCQ, IL2RA, IL2
5	Apolipoprotein A-I and cholesterol in synovial fluid of patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritis. (19327233)	Oliviero F.... Punzi L.	2009	APOA1, LPA
6	Interleukin 11 and paired immunoglobulin-like type 2 receptor alpha expression correlates with the number of joints with active arthritis in systemic juvenile idiopathic arthritis. (19139207)	Mima T.... Nishimoto N.	2009	PILRA
7	Soluble neuropilin-2, a nerve repellent receptor, is increased in rheumatoid arthritis synovium and aggravates sympathetic fiber rep ulsion and arthritis. (19790074)	Fassold A.... Straub R.H.	2009	NRP2, SEMA3F
8	Peritonitis and cervical arthritis as presenting manifestations of systemic juvenile idiopathic arthritis. (19032844)	Vaz A.... Salgado M.	2008	CCL2
9	The comparative one-year performance of anti-tumor necrosis factor alpha drugs in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis: results from a longitudinal, observational, multicenter study. (18240258)	Heiberg M.S.... Kvien T.K.	2008	TNF
10	Efficacy and tolerability of anti-tumour necrosis factor therapy in psoriatic arthritis patients: results from the South Swedish Arthritis Treatment Group register. (17644547)	Kristensen L.E.... Geborek P.	2008	TNF, CRP
11	Adiponectin mitigates the severity of arthritis in mice with collagen-induced arthritis. (18612926)	Lee S.W.... Lee S.K.	2008	ADIPOQ
12	Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis. (18838388)	Harrison P.... Wordsworth B.P.	2008	IL1B, IL1A, HLA-DRB1
13	Investigating the role of the HLA-Cw*06 and HLA-DRB1 genes in susceptibility to psoriatic arthritis: comparison with psoriasis and undifferentiated inflammatory arthritis. (17728335)	Ho P.Y.... Bruce I.N.	2008	HLA-DRB1, HLA-C
14	The future of the IL-1 receptor antagonist anakinra: from rheumatoid arthritis to adult-onset Still's disease and systemic-onset juvenile idiopathic arthritis. (18321234)	Kalliolias G.D.... Liossis S.N.	2008	TNF, IL1RN, IL1RAPL2
15	Association of DRB1 shared epitope genotypes with early mortality in rheumatoid arthritis: results of eighteen years of followup from the early rheumatoid arthritis study. (17469097)	Mattey D.L.... Young A.	2007	HLA-DRB1
16	Polymorphisms within the IL-1 gene cluster: effects on cytokine profiles in peripheral blood and whole blood cell cultures of patients with aggressive periodontitis, juvenile idiopathic arthritis, and rheumatoid arthritis. (17335371)	Havemose-Poulsen A.... Holmstrup P.	2007	TNF, IL1B, IL1A
17	Angiotensin II type 1 receptor as a novel therapeutic target in rheumatoid arthritis: in vivo analyses in rodent models of arthritis and ex vivo analyses in human inflammatory synovitis. (17265479)	Price A.... Sturrock R.D.	2007	AGTR1
18	Assessment of upper gastrointestinal safety of etoric oxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) progra mme: a randomised comparison. (17292766)	Laine L.... Cannon C.P.	2007	PTGS2
19	The FCRL3 -169T>C polymorphism is associated with rheumatoid arthritis and shows suggestive evidence of involvement with juvenile idiopathic arthritis in a Scandinavian panel of autoimmune diseases. (18065500)	Eike M.C.... Lie B.A.	2007	PTPN22, FCRL3
20	Risk: benefit profile of etanercept in elderly patien ts with rheumatoid arthritis, ankylosing spondylitis or psoriatic arthritis. (17362051)	Fleischmann R.... Iqbal I.	2007	TNF
21	Identification of arthritis-related gene clusters by microarray analysis of two independent mouse models for rheumatoid arthritis. (16805906)	Fujikado N.... Iwakura Y.	2006	IL1R1
22	Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis. (17038468)	Koenders M.I.... van den Berg W.B.	2006	TNF, IL17A
23	Expression of Jak3, STAT1, STAT4, and STAT6 in inflammatory arthritis: unique Jak3 and STAT4 expression in dendritic cells in seropositive rheumatoid arthritis. (16096332)	Walker J.G.... Smith M.D.	2006	JAK3, STAT1, STAT6
24	Enumeration and phenotypical analysis of distinct dendritic cell subsets in psoriatic arthritis and rheumatoid arthritis. (16507115)	Jongbloed S.L.... McInnes I.B.	2006	TLR2, IL10, TLR9
25	Elevated concentrations of monocyte derived cytokines in synovial fluid of children with enthesitis related arthritis and polyarticular types of juvenile idiopathic arthritis. (15996076)	Saxena N.... Misra R.	2005	IL6, IL2, IL8
26	SLC22A4 polymorphisms implicated in rheumatoid arthritis and Crohn's disease are not associated with rheumatoid arthritis in a Canadian Caucasian population. (15693005)	Newman B.... Siminovitch K.A.	2005	SLC22A4
27	Cellular and humoral markers of systemic inflammation in acute reactive arthritis and early rheumatoid arthritis. (15124937)	Kuuliala A.... Repo H.	2004	SELE, ITGAM
28	Serum levels of cartilage oligomeric matrix protein are elevated in rheumatoid arthritis, but not in inflammatory rheumatic diseases such as psoriatic arthritis, reactive arthritis, Raynaud's syndrome, scleroderma, systemic lupus erythematosus, vasculitis and SjAPgren's syndrome. (15059267)	Skoumal M.... Dunky A.	2004	COMP
29	Anti-tumor necrosis factor alpha switching in rheumat oid arthritis and juvenile chronic arthritis. (15077278)	Favalli E.G.... Pontikaki I.	2004	TNF
30	Heat shock protein 60 and adjuvant arthritis: a model for T cell regulation in human arthritis. (12904891)	Prakken B.J.... van Eden W.	2003	HSPD1
31	HLA-DRB1*0402 (DW10) transgene protects collagen-induced arthritis-susceptible H2Aq and DRB1*0401 (DW4) transgenic mice from arthritis. (14530370)	Taneja V.... David C.S.	2003	HLA-DRB1
32	Inadequately low serum levels of steroid hormones in relation to interleukin-6 and tumor necrosis factor in untreated patients with early rheumatoid arthritis and reactive arthritis. (11920401)	Straub R.H.... Leirisalo-Repo M.	2002	IL6
33	Mass spectrometric proteome analyses of synovial fluids and plasmas from patients suffering from rheumatoid arthritis and comparison to reactive arthritis or osteoarthritis. (12373775)	Sinz A.... Glocker M.O.	2002	S100A12
34	Matrix metalloproteinase 9 (MMP-9) in patients with psoriatic arthritis and rheumatoid arthritis. (11791658)	Alenius G.M.... RantapAoAo Dahlqvist S.	2001	MMP9
35	Genetic anticipation in rheumatoid arthritis in Europe. European Consortium on Rheumatoid Arthritis Families. (11361223)	Radstake T.R.... van Riel P.L.	2001	HLA-DRA
36	The immunoglobulin (IgG) antibody response to OspA and OspB correlates with severe and prolonged Lyme arthritis and the IgG response to P35 correlates with mild and brief arthritis. (9864212)	Akin E.... Steere A.C.	1999	CDK5R1
37	Pentosidine in synovial fluid in osteoarthritis and rheumatoid arthritis: relationship with disease activity in rheumatoid arthritis. (9858442)	Chen J.R.... Inoue T.	1998	CRP
38	HLA-DRB1 genes and disease severity in rheumatoid arthritis. The MIRA Trial Group. Minocycline in Rheumatoid Arthritis. (8912501)	Reveille J.D.... Tilley B.	1996	HLA-DRB1
39	Interleukin-2 is found in the synovium of psoriatic arthritis and spondyloarthritis, not in rheumatoid arthritis. (8792801)	Wong W.M.... Smith J.L.	1996	IL2
40	Dose-range and dose-frequency study of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. The IL-1Ra Arthritis Study Group. (8670316)	Campion G.V.... Catalano M.	1996	IL1R1, IL1RN
41	Juvenile chronic arthritis: T cell reactivity to human HSP60 in patients with a favorable course of arthritis. (7883993)	De Graeff-Meeder E.R.... Zegers B.J.	1995	HSPD1
42	Collagen-induced arthritis as a model of rheumatoid arthritis. (7923907)	Durie F.H.... Noelle R.J.	1994	CD96
43	Prolactin response to protirelin in reactive arthritis and ankylosing spondyloarthritis. Failure of treatment of 4 reactive arthritis with bromocriptine (7858584)	Eulry F.... Lechevalier D.	1994	TRH
44	Reduced synovial membrane macrophage numbers, ELAM-1 expression, and lining layer hyperplasia in psoriatic arthritis as compared with rheumatoid arthritis. (7686370)	Veale D.... FitzGerald O.	1993	SELE
45	IL-1 receptor antagonist in arthritis and arthritis m odels. (8324943)	Thompson R.C.	1993	IL1RAPL2
46	Plasma interleukin-6 and renin substrate in reactive arthritis, rheumatoid arthritis, and systemic lupus erythematosus. (1384103)	MetsAorinne K.P.... Fyhrquist F.Y.	1992	IL6, CRP
47	Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha. (2026869)	Alvaro-Gracia J.M.... Firestein G.S.	1991	CSF2
48	Osteocalcin in rheumatoid arthritis--a marker for accelerated bone turnover in late-onset rheumatoid arthritis? (2060966)	Marhoffer W.... Federlin K.	1991	BGLAP
49	Endothelial cells and the pathogenesis of rheumatoid arthritis in humans and streptococcal cell wall arthritis in Lewis rats. (2055944)	Wilder R.L.... Yocum D.E.	1991	FOS
50	IL-6 gene polymorphism in rheumatoid arthritis, pauciarticular juvenile rheumatoid arthritis, systemic lupus erythematosus, and in healthy Danes. (2577114)	Fugger L.... Svejgaard A.	1989	IL6

Genes related to arthritis according to GeneCards:

(show top 50)    (show all 1641)

id	Symbol	Description	Score	GeneCards Section Context
1	SERPINH1	serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)	11.1	Publications, Aliases & Descriptions, Summaries
2	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications, Pathways & Interactions, Summaries
3	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0	Publications, Pathways & Interactions, Summaries
4	MMP9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)	11.0	Publications, UniProt Related, Summaries
5	IL10	interleukin 10	11.0	Publications, Summaries
6	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications, Pathways & Interactions, Summaries
7	MMP8	matrix metallopeptidase 8 (neutrophil collagenase)	11.0	Publications, Summaries
8	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.0	Publications, Summaries
9	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0	Publications, Functions, Summaries
10	MMP12	matrix metallopeptidase 12 (macrophage elastase)	11.0	Publications, Functions, Summaries
11	PTPN22	protein tyrosine phosphatase, non-receptor type 22 (lymphoid)	11.0	Publications, Summaries
12	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications, Summaries
13	CIITA	class II, major histocompatibility complex, transactivator	11.0	Publications, Summaries
14	IL1A	interleukin 1, alpha	11.0	Publications, Pathways & Interactions, Summaries
15	MMP19	matrix metallopeptidase 19	11.0	Publications, Summaries
16	BST1	bone marrow stromal cell antigen 1	11.0	Summaries, Publications
17	MMP10	matrix metallopeptidase 10 (stromelysin 2)	11.0	Publications, Summaries
18	MMP15	matrix metallopeptidase 15 (membrane-inserted)	11.0	Publications, Summaries
19	MMP17	matrix metallopeptidase 17 (membrane-inserted)	11.0	Publications, Summaries
20	TNIP1	TNFAIP3 interacting protein 1	11.0	Summaries, Publications
21	MMP11	matrix metallopeptidase 11 (stromelysin 3)	11.0	Publications, Summaries
22	MMP14	matrix metallopeptidase 14 (membrane-inserted)	11.0	Publications, Summaries
23	IL17A	interleukin 17A	11.0	Publications, Pathways & Interactions, Summaries
24	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications, Summaries
25	MMP20	matrix metallopeptidase 20	11.0	Publications, Summaries
26	MMP7	matrix metallopeptidase 7 (matrilysin, uterine)	11.0	Publications, Summaries
27	MMP16	matrix metallopeptidase 16 (membrane-inserted)	11.0	Publications, Summaries
28	STAT4	signal transducer and activator of transcription 4	11.0	Publications, Summaries
29	CCL2	chemokine (C-C motif) ligand 2	11.0	Publications, Functions, Pathways & Interactions, Summaries
30	FCRL3	Fc receptor-like 3	11.0	Publications, Summaries
31	CTSK	cathepsin K	11.0	Publications, Pathways & Interactions, Summaries
32	NR4A2	nuclear receptor subfamily 4, group A, member 2	11.0	Publications, Summaries
33	VCAM1	vascular cell adhesion molecule 1	11.0	Publications, Summaries
34	MMP23B	matrix metallopeptidase 23B	11.0	Summaries
35	MMP25	matrix metallopeptidase 25	11.0	Summaries
36	MMP26	matrix metallopeptidase 26	11.0	Summaries
37	MMP27	matrix metallopeptidase 27	11.0	Summaries
38	MMP24	matrix metallopeptidase 24 (membrane-inserted)	11.0	Summaries
39	SAA1	serum amyloid A1	11.0	Publications, Functions, Summaries
40	TNFAIP6	tumor necrosis factor, alpha-induced protein 6	11.0	Expressions, Publications, Summaries
41	IL17RA	interleukin 17 receptor A	11.0	Publications, Summaries
42	C5AR1	complement component 5a receptor 1	11.0	Publications, Summaries
43	CTSL1	cathepsin L1	11.0	Publications, Pathways & Interactions, Summaries
44	PTGES	prostaglandin E synthase	11.0	Publications, Summaries
45	C3	complement component 3	11.0	Publications, Summaries
46	DDX39B	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	11.0	Publications, Summaries
47	C5	complement component 5	11.0	Publications, Summaries
48	CARD8	caspase recruitment domain family, member 8	11.0	Publications, Summaries
49	FSTL1	follistatin-like 1	11.0	Expressions, Publications, Summaries
50	HAS1	hyaluronan synthase 1	11.0	Publications, Summaries

Pathways related to arthritis according to GeneDecks:

(show top 50)    (show all 276)

id	Pathway	Score	Top Affiliating Genes
1	Antioxidant Action of Vitamin-C36	45.9	NCF1, NCF4, KIT, KITLG, BTK, VEGFB
2	JAK-STAT Pathway36	37.0	KIT, KITLG, BTK, VEGFB, VEGFC, MYC
3	ERK Signaling36	36.3	KIT, KITLG, BTK, BRAF, VEGFB, VEGFC
4	Transendothelial Migration of Leukocytes36	30.8	NCF1, NCF4, RDX, BTK, VCAM1, MYO3A
5	all-trans-Retinoic Acid Signaling in Brain36	27.6	BTK, BMP2, BMP4, BMP5, BMP6, BMP7
6	Endothelin-1 Signaling Pathway36	26.9	KIT, BTK, BRAF, MYC, BMP2, BMP4
7	Phospholipase-C Pathway36	26.1	KIT, KITLG, BTK, VEGFB, VEGFC, BMP2
8	Phagosome20	24.0	NCF1, NCF4, SFTPD, RAC1, CLEC7A, MSR1
9	MAPK signaling pathway20	23.4	RELA, RELB, BRAF, MYC, RAP1A, RASGRF1
10	UPA-UPAR Pathway36	21.8	VTN, SERPINE1, JUN, JAK1, JAK2, ITGA1
11	Rac1 Pathway36	21.3	KITLG, VEGFB, BMP4, BMP5, BMP6, BMP7
12	DHA Signaling36	21.2	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP4
13	Jak-STAT signaling pathway20	21.1	PIK3CD, PIK3CG, CNTF, MYC, LIFR, CLCF1
14	PPAR Pathway36	20.8	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP4
15	Paxillin Interactions36	20.6	KIT, KITLG, VEGFB, VEGFC, BMP2, BMP4
16	Natural killer cell mediated cytotoxicity20	19.6	PIK3CD, PIK3CG, SH2D1A, KIR2DS3, KIR2DL1, KIR2DL3
17	Colorectal Cancer Metastasis36	19.1	LRP5, BRAF, MYC, BIRC5, BCL2L1, BAX
18	Nanog in Mammalian ESC Pluripotency36	19.0	KIT, KITLG, BRAF, VEGFB, VEGFC, BMP2
19	Intestinal immune network for IgA production20	18.7	CD28, CD86, CD40LG, CD80, CD40, ITGA4
20	Staphylococcus aureus infection20	18.1	SELP, CFB, CFD, CFH, CFI, ITGAL
21	Antigen processing and presentation20	17.9	KIR2DS3, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, KIR2DS1
22	T cell receptor signaling pathway20	17.5	PIK3CD, PIK3CG, PDCD1, RELA, RAF1, CHUK
23	Lymphocyte Signaling3	17.5	SH2D1A, NCF1, NCF4, KIT, KITLG, BTK
24	PKC-Theta Pathway36	17.5	RAC1, CHUK, ZAP70, LCK, LAT, JUN
25	Th17 Differentiation37	17.4	JAK1, JAK2, CD28, CD86, CD4, CD80
26	Cytokine production by Th17 cells in CF41	17.2	REL, RELA, RELB, MYD88, CHUK, LBP
27	Immune response IL-12-induced IFN-gamma production10	17.2	REL, RELA, RELB, CHUK, ATF2, JUN
28	Integrin Pathway36	17.2	BRAF, MYC, RAF1, RAC1, JUN, ITGA1
29	CREB Pathway36	17.1	KIT, KITLG, VEGFB, BMP2, BMP4, BMP5
30	TREM1 Pathway36	16.8	BRAF, MYD88, RAF1, BID, CHUK, BAX
31	Immune response CD16 signaling in NK cells10	16.8	PIK3CD, RAF1, RAC1, ZAP70, LCK, LAT
32	Mucin expression in CF via TLRs, EGFR signaling pathways41	16.8	REL, RELA, RELB, MYD88, RAF1, CHUK
33	Th1 Differentiation37	16.7	JUN, JAK1, JAK2, CD28, CD86, CD4
34	Transcription NF-kB signaling pathway10	16.6	REL, RELA, RELB, MYD88, CHUK, LBP
35	Neurotrophin signaling pathway20	16.3	PIK3CD, PIK3CG, SH2B3, RELA, BRAF, RAP1A
36	Phagocytosis of Microbes36	16.2	VTN, RAC1, MSR1, ITGA1, ITGA2, ITGA4
37	Sertoli-Sertoli Cell Junction Dynamics36	16.0	BRAF, RAF1, RAC1, CLDN11, MPP6, JAM3
38	Development_VEGF signaling via VEGFR2 - generic cascades41	16.0	PIK3CD, SH2D2A, RELA, VEGFA, RAF1, RAC1
39	LPS Stimulated MAPK Signaling36	15.6	RAF1, RAC1, CHUK, LBP, ATF2, JUN
40	Immune response_MIF-mediated glucocorticoid regulation41	15.5	REL, RELA, RELB, VCAM1, CHUK, JUN
41	Apoptosis and survival TNFR1 signaling pathway10	15.3	REL, RELA, RELB, BID, BCL2, CHUK
42	G-protein signaling_N-RAS regulation pathway41	14.8	BRAF, RASGRF1, RAF1, ZAP70, LCK, LAT
43	G-protein signaling N-RAS regulation pathway10	14.8	BRAF, RASGRF1, RAF1, ZAP70, LCK, LAT
44	Development_VEGF signaling and activation41	14.7	REL, RELA, RELB, SELE, VEGFA, VCAM1
45	LT-BetaR Pathway36	14.7	RELA, RELB, CHUK, MAP3K14, MAPK3, MAPK1
46	Actin-Based Motility by Rho Family GTPases36	14.6	BMP4, BMP5, BMP7, BDNF, ITGA4, ITGA6
47	Immune response Oncostatin M signaling via MAPK in human cells10	14.6	RAF1, RAC1, LIFR, CEBPB, ATF2, JUN
48	Signal transduction_AKT signaling41	14.2	PIK3CD, REL, RELA, RELB, PCNA, MYC
49	Fc epsilon RI signaling pathway20	14.0	PIK3CD, PIK3CG, BTK, RAC1, LAT, IL4
50	TNF-Induced Apoptosis Implicating Sphingolipids36	13.5	RAF1, BAX, FADD, MAPK8, MAP2K6, MAP2K3

Compounds related to arthritis according to GeneDecks:

(show top 50)    (show all 472)

id	Compound	Score	Top Affiliating Genes
1	serine32	98.1	PIK3CD, PIK3CG, PIN1, LRP1, LRP2, KLF5
2	vegf32	63.3	PIK3CG, LRP1, SH2D2A, KL, PDE4A, RECK
3	estrogen32	48.4	LRP5, KLF5, RETN, VWF, RDX, PCNA
4	cyclosporin a32 42	47.2	PIK3CG, PIN1, PDE4A, RECK, REL, CNTN2
5	cisplatin32 34 9 9	42.8	CNR2, KITLG, VTN, PCNA, RB1, SETD2
6	h2o232	38.8	PIK3CG, PDE4A, CNTF, CNTN2, KITLG, VWF
7	polysaccharide32	33.2	RECK, KITLG, VTN, SFTPD, SELE, SELL
8	doxorubicin32 34 9 9	32.9	PIK3CG, RECK, KIT, KITLG, SELE, SETD2
9	prostaglandin32	28.4	PDE4A, CNTF, KITLG, VIM, VIP, VEGFC
10	tacrolimus32 34 9 9	31.1	PIN1, REL, VTN, PCNA, SERPINE1, NAGLU
11	phospholipid32	26.3	LRP2, PDE4A, VWF, SFTPD, SERPINA1, LPAR1
12	ly29400232	26.2	PIK3CG, RETN, VTN, SELE, VEGFA, LEP
13	chloramphenicol32 9 9	27.8	REL, CNTN2, GC, RBP3, SELE, SERPINC1
14	etoposide32 42 9 9	28.1	PIK3CG, RECK, CNTN2, PCNA, RB1, SELE
15	magnesium32 9 18 9	26.6	LRP2, PDE4A, GC, NAGLU, BPI, RAG1
16	p00232	22.2	RETN, KIT, RB1, SERPINB5, BRAF, LPA
17	glycerol32 9 18 9	24.5	PDE4A, VWF, PCNA, SERPINC1, LPAR1, LPL
18	cocaine32 9 9	23.3	PDE4A, CNR1, CNTF, SELE, SELP, VIM
19	alpha tocopherol32	21.3	SEC14L2, LPL, VCAM1, LIF, BGLAP, LEP
20	procollagen32	20.1	PCNA, SERPINH1, VIM, BMP2, BMP6, BGLAP
21	allergens32	20.0	LRP2, PDCD1, SFTPD, BLZF1, SCG5, LGALS3
22	sodium dodecylsulfate32	19.6	LRP1, VWF, VTN, SERPINA7, SERPINF2, SERPINE1
23	chondroitin sulfate32 18	20.6	VTN, GC, VIM, BMP6, CHST3, UGDH
24	thalidomide32 42 9 9	22.5	PDE4A, VTN, SELL, VEGFA, BIRC5, KDR
25	mg 13232 42	20.5	PIK3CG, PCNA, VDR, MYC, BLZF1, BID
26	celecoxib32 42 34 9 18 9	24.3	PIK3CG, PCNA, VEGFA, BIRC5, PARP1, KDR
27	corticosterone32 18	20.1	CNR1, SERPINA7, SERPINA6, VIP, LIF, BGLAP
28	camptothecin32 42 9 9	21.9	PIK3CG, CNTN2, PCNA, RB1, SETD2, MYC
29	vitamin-e32	18.8	CNTF, SERPINB2, SEC14L2, NAGLU, LPA, VCAM1
30	ifn-alpha32	18.6	LIF, PARK2, CISH, MX1, JAK1, CDK2
31	manganese superoxide32	17.7	REL, SERPINB2, VCAM1, BCL2L1, XRCC1, ATM
32	guanidine hydrochloride32	17.5	CNTF, VWF, SERPINA3, LPL, BMP2, BMP4
33	sialic acid32	17.5	RECK, SELL, SERPINA7, SERPINF2, SERPINA6, SERPINA3
34	8-isoprostane32	17.0	RETN, SELE, SERPINE1, VCAM1, LEP, SAA4
35	gefitinib32 34 9 9	20.0	PIK3CG, KIT, SFTPD, SELP, VIM, VEGFA
36	mitomycin c32	16.7	VWF, PCNA, RB1, VCAM1, BIRC5, XIAP
37	fluvastatin32 34 9 9	19.6	VWF, SELP, SERPINE1, LPL, VCAM1, BMP2
38	phenylalanine32	16.2	BTK, SERPINA7, BLZF1, BEST1, BDNF, SCG5
39	neomycin32	15.8	KITLG, VIM, BMP2, CDKN2A, GUSB, GRP
40	anti-fungal32	15.7	REL, SFTPD, BPI, CHGA, CD79A, CDKN2A
41	dermatan sulfate32	15.5	VWF, VTN, SELP, SERPINC1, BMP6, CD36
42	rotenone32	15.2	PIK3CG, PARP1, PARK2, BCL2, BCL2L1, XDH
43	pravastatin32 34 9 18 9	19.1	SELE, SELP, SERPINE1, LPA, BMP2, RAC1
44	pd 16679342	14.8	MMP1, MMP10, MMP11, MMP12, MMP14, MMP15
45	mitoxantrone32 9 9	16.3	BIRC5, BCL2, MTOR, ATM, MPO, IL3
46	silicone32	14.3	CNTF, VTN, SELE, SERPINC1, VIM, CD79A
47	tpck32	14.2	PIK3CG, PARP1, BCL2L1, BAK1, JUN, IL1B
48	25-hydroxyvitamin d32	14.0	GC, SEC14L2, VDR, BGLAP, PAX5, SCG5
49	depsipeptide32	13.6	KITLG, RB1, SERPINB5, BRAF, MYC, RAF1
50	levonorgestrel32 9 9	15.6	SERPINC1, SERPINA7, SERPINA6, MMP1, MMP3, AR

Cellular components related to arthritis according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	plasma membrane	GO:005886	77.2	PIK3CD, PILRA, PIK3CG, LRP2, LRP5, KL
2	extracellular region	GO:005576	67.3	PILRA, KL, PDCD1LG2, RETN, KITLG, VWF
3	extracellular space	GO:005615	64.4	LRP2, KL, RELN, CNTF, KIT, KITLG
4	cytoplasm	GO:005737	60.4	ZNF395, PIP4K2C, PIK3CG, PIN1, LRP1, SH2D1A
5	cytosol	GO:005829	52.9	PIK3CD, PIK3CG, SH2B3, NDEL1, NCF1, NCF4
6	integral to plasma membrane	GO:005887	45.1	LRP1, KL, CNR1, CNR2, CNTN2, KIR2DS3
7	external side of plasma membrane	GO:009897	26.9	KIT, VWF, BTLA, SELL, SELP, SEMA7A
8	cell surface	GO:009986	25.6	CNTN2, SFRP1, BST2, VEGFA, LPAR1, LPL
9	membrane	GO:016020	25.2	PIP4K2C, PIK3CG, NCF4, PDE4A, RECK, CNTN1
10	proteinaceous extracellular matrix	GO:005578	20.5	RELN, VWF, SFRP1, SERPINA1, VEGFA, BMP4
11	extracellular matrix	GO:031012	17.8	VWF, VTN, SFRP1, SERPINE1, LPL, RARRES2
12	membrane raft	GO:045121	17.1	BTK, SELE, BSG, BST2, UMOD, LCK
13	endosome membrane	GO:010008	16.8	MYD88, USP8, UBC, ATP6V0D1, ATP6V0E2, ATP6V0A4
14	platelet alpha granule lumen	GO:031093	14.8	VWF, SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFB

Biological processes related to arthritis according to GeneDecks:

(show top 50)    (show all 83)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	46.2	PIK3CD, PILRA, SH2D2A, PDCD1, PDE4A, CNTF
2	immune response	GO:006955	43.3	NCF4, PDCD1LG2, CNR2, KIR2DL1, KIR2DL3, KIR3DS1
3	inflammatory response	GO:006954	40.1	PIK3CD, PIK3CG, RELA, CNR2, KIT, SELE
4	apoptotic process	GO:006915	29.6	PDCD1, PDCD5, BTK, RBM5, VIM, BOK
5	blood coagulation	GO:007596	27.8	PIK3CG, SH2B3, KIF5A, VWF, SELL, SELP
6	proteolysis	GO:006508	27.4	RELN, CNDP2, RBP3, SENP1, LPA, LAP3
7	cell-cell signaling	GO:007267	26.7	SH2D1A, BST2, NAMPT, BMP2, CHST4, S100A9
8	cell adhesion	GO:007155	25.5	RELN, CNTN1, CNTN2, KITLG, VWF, VTN
9	response to drug	GO:042493	23.8	LRP2, PDE4A, SFRP1, SEMA3C, SERPINA7, VEGFC
10	virus-host interaction	GO:019048	23.3	PILRA, RELA, RB1, VIM, VCAM1, CLEC5A
11	cytokine-mediated signaling pathway	GO:019221	23.2	PIN1, RELA, KIT, VCAM1, MYD88, LIFR
12	negative regulation of apoptotic process	GO:043066	21.9	PIK3CG, RELA, SFRP1, SERPINE1, BRAF, VEGFA
13	anti-apoptosis	GO:006916	21.9	RELA, SERPINB2, BRAF, VEGFB, MYD88, BIRC5
14	platelet activation	GO:030168	21.2	PIK3CG, VWF, SELP, SERPINF2, SERPINA1, SERPINE1
15	response to lipopolysaccharide	GO:032496	20.8	CNR1, CNR2, SELE, SELP, SERPINA1, LBP
16	cell surface receptor signaling pathway	GO:007166	20.8	BSG, MYD88, LIFR, CLCF1, CLEC4A, SAG
17	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	20.5	REL, RELA, BST2, LPAR1, MYD88, PARK2
18	positive regulation of apoptotic process	GO:043065	20.0	CNR1, SFRP1, RBM5, LPAR1, BMP2, BMP4
19	positive regulation of NF-kappaB transcription factor activity	GO:051092	18.5	RELA, BTK, MYD88, CLU, CHUK, UBC
20	Toll signaling pathway	GO:008063	17.9	RELA, BTK, MYD88, CHUK, UBC, LBP
21	induction of apoptosis	GO:006917	17.9	PDCD5, BOK, BCL2L11, MX1, BBC3, LCK
22	aging	GO:007568	17.8	LRP2, KL, CNR1, SERPINA7, VDR, VCAM1
23	positive regulation of cell migration	GO:030335	17.7	VEGFA, BMP2, KDR, JAK2, CDH13, ITGAV
24	leukocyte migration	GO:050900	17.7	SELL, SELP, BSG, LCK, B4GALT1, MSN
25	toll-like receptor 4 signaling pathway	GO:034142	17.7	RELA, BTK, MYD88, CHUK, UBC, ATF2
26	regulation of immune response	GO:050776	17.6	KIR2DL1, KIR2DL3, KIR3DL1, KIR2DS2, KIR2DS1, KIR2DL2
27	MyD88-dependent toll-like receptor signaling pathway	GO:002755	17.5	RELA, BTK, MYD88, CHUK, UBC, ATF2
28	T cell costimulation	GO:031295	17.5	PDCD1, PDCD1LG2, BTLA, RAC1, LCK, MTOR
29	platelet degranulation	GO:002576	17.4	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
30	toll-like receptor signaling pathway	GO:002224	17.1	RELA, BTK, MYD88, CHUK, UBC, ATF2
31	toll-like receptor 3 signaling pathway	GO:034138	16.8	RELA, CHUK, UBC, ATF2, JUN, CD14
32	response to organic cyclic compound	GO:014070	16.7	SFRP1, SELP, SERPINA1, BMP4, BAK1, P2RX7
33	TRIF-dependent toll-like receptor signaling pathway	GO:035666	16.7	RELA, CHUK, UBC, ATF2, JUN, CD14
34	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	16.5	RELN, KITLG, VTN, VEGFA, VEGFB, LIF
35	MyD88-independent toll-like receptor signaling pathway	GO:002756	16.4	RELA, CHUK, UBC, ATF2, JUN, FOS
36	cellular iron ion homeostasis	GO:006879	16.2	MYC, ATP6V1G1, ATP6V1B1, ATP6V0D1, ATP6V1C2, ATP6V0E2
37	T cell receptor signaling pathway	GO:050852	16.1	PIK3CD, RELA, CHUK, ZAP70, UBC, LCK
38	positive regulation of T cell proliferation	GO:042102	15.7	PDCD1LG2, VCAM1, CD276, CD28, CD1D, ITGAL
39	positive regulation of inflammatory response	GO:050729	15.7	SERPINE1, JAK2, IL12B, IL15, IL18, IL1RL1
40	positive regulation of protein phosphorylation	GO:001934	15.7	PIN1, VEGFA, BMP2, BMP4, MTOR, CD40
41	positive regulation of endothelial cell proliferation	GO:001938	15.5	VEGFA, VEGFB, BMP2, BMP4, BMP6, KDR
42	response to estradiol stimulus	GO:032355	15.4	GC, SERPINA1, VDR, BMP4, BID, UCN
43	negative regulation of inflammatory response	GO:050728	15.3	CNR2, SERPINC1, ZFP36, MVK, SAA1, CD276
44	cellular defense response	GO:006968	15.3	SH2D1A, NCF1, RELA, KIR2DS3, CLEC5A, LGALS3BP
45	humoral immune response	GO:006959	15.1	SH2D1A, PDCD1, BST1, BST2, PAX5, BCL2
46	defense response to virus	GO:051607	15.0	RELA, BST2, LILRB1, BCL2, UNC13D, CD86
47	positive regulation of protein kinase B signaling cascade	GO:051897	14.9	PIK3CG, VEGFB, CHI3L1, MTOR, AXL, MST1R
48	positive regulation of interleukin-6 production	GO:032755	14.8	MYD88, UCN, LBP, P2RX7, CD36, FIGF
49	interaction with host	GO:051701	14.2	NCF1, NCF4, ATP6V1G1, ATP6V1B1, ATP6V0D1, ATP6V1C2
50	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	GO:035872	14.1	BCL2, BCL2L1, CHUK, UBC, P2RX7, ITCH

Molecular functions related to arthritis according to GeneDecks:

(show all 12)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	106.2	PIK3CD, PILRA, PIK3CG, PIN1, LRP1, LRP2
2	protein homodimerization activity	GO:042803	27.8	KIT, VWF, SERPINF2, BST2, VEGFA, VEGFB
3	cytokine activity	GO:005125	26.4	CNTF, KITLG, NAMPT, VEGFA, BMP2, BMP4
4	receptor binding	GO:005102	23.6	SERPINE1, LPL, BMP2, RARRES2, LIF, CLCF1
5	growth factor activity	GO:008083	20.9	CNTF, KITLG, VEGFA, VEGFB, VEGFC, BMP2
6	receptor activity	GO:004872	20.0	LRP1, KIR2DL1, KIR2DL3, BTLA, SEMA3C, SEMA7A
7	heparin binding	GO:008201	19.4	VTN, SFRP1, SELL, SELP, SERPINC1, VEGFA
8	identical protein binding	GO:042802	19.2	PIP4K2C, RELA, CNTN2, SFRP1, PCNA, BTK
9	protein heterodimerization activity	GO:046982	18.6	BRAF, VEGFA, VEGFB, BOK, MYC, BMP2
10	chemokine activity	GO:008009	17.4	XCL1, IL8, CCL8, CCL4, CCL15, CCL7
11	transmembrane signaling receptor activity	GO:004888	16.8	KIR2DS2, KIR2DS1, SELE, CLEC4A, CD79A, CD27
12	tumor necrosis factor receptor binding	GO:005164	14.0	CD70, CD40LG, FASLG, FADD, CASP8, ERAP1