MCID: ART022
MIFTS: 75

Arthritis malady

Summaries for Arthritis

About this section
Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:33 If you feel pain and stiffness in your body or have trouble moving around, you might have arthritis. most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. over time, a swollen joint can become severely damaged. some kinds of arthritis can also cause problems in your organs, such as your eyes or skin. types of arthritis include osteoarthritis is the most common type of arthritis. it's often related to aging or to an injury. autoimmune arthritis happens when your body's immune system attacks healthy cells in your body by mistake. rheumatoid arthritis is the most common form of this kind of arthritis. juvenile rheumatoid arthritis is a form of the disease that happens in children. infectious arthritis is an infection that has spread from another part of the body to the joint. psoriatic arthritis affects people with psoriasis. gout is a painful type of arthritis that happens when too much uric acid builds up in the body. it often starts in the big toe. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and psoriatic arthritis. An important gene associated with Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Collagen biosynthesis and modifying enzymes and Matrix Metalloproteinases. The drugs meclofenamate sodium and salsalate and the compounds vegf and calcium have been mentioned in the context of this disorder. Affiliated tissues include skin over the joint, joint and bone, and related mouse phenotypes are immune system and cardiovascular system.

Disease Ontology:8 A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located in joint and/or redness located in skin over the joint.

CDC:3 Arthritis affects 52.5 million U.S. adults, more than 1 in 5. It is the nation’s most common cause of disability. Learn more about arthritis, the proven ways to manage it and the resources available to public health professionals.

Wikipedia:63 Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint... more...

Aliases & Classifications for Arthritis

About this section
Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

arthritis 8 10 44 33 60
inflammatory joint disease 44 60
inflammatory disorder of joint 8


External Ids:

Disease Ontology8 DOID:848
NCIt39 C2883
MeSH34 D001168
ICD1025 M13.8, M13.9

Related Diseases for Arthritis

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Arthritis family:

Transient Arthritis

Diseases related to Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 909)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis32.4SERPINH1, PTPN22, MMP9, MMP1, MMP11, MMP19
2psoriatic arthritis31.7IL1A, MMP3, MMP1, PTPN22
3juvenile rheumatoid arthritis31.6IL6, IL1A, LTA
4osteoarthritis31.3LTA, IL1A, IL6, MMP13, MMP3, MMP2
5psoriasis31.2LTA, IL10, IL1A, IL6, MMP19, PTPN22
6systemic lupus erythematosus31.2SERPINH1, PTPN22, MMP3, IL6, IL10, LTA
7synovitis31.1MMP1, MMP11, MMP8, MMP3, MMP13, IL6
8uveitis30.9IL1A, IL10, LTA
9pneumonia30.8MMP12, MMP8, IL6, IL10
10tuberculosis30.7IL10
11atherosclerosis30.7MMP13, IL6, IL1A, IL10, MMP3, MMP10
12periodontitis30.7MMP9, MMP8, IL1A
13glomerulonephritis30.7SERPINH1
14hepatitis30.7LTA
15dermatitis30.7IL1A
16interstitial lung disease30.6MMP9
17osteoporosis30.6IL6, MMP13, MMP3, MMP8
18leukemia30.6BST1, LTA, IL1A, IL6
19connective tissue disease30.6IL10, IL6, PTPN22
20arthropathy30.6MMP13, MMP3, MMP1
21thyroiditis30.4PTPN22
22myositis30.4IL1A
23vascular disease30.4IL10, IL1A, IL6, MMP3, MMP2
24periodontal disease30.4IL6, MMP3, MMP2, MMP1
25hepatitis c30.4IL10
26asthma30.3IL10, MMP3, MMP8, MMP12, MMP9
27diabetes mellitus30.3IL6, MMP3, MMP9, PTPN22
28obesity30.3MMP3, IL6
29ulcerative colitis30.3LTA, IL10, IL1A, IL6, MMP13, MMP3
30skin disease30.2MMP9, IL6, IL1A
31meningitis30.2MMP9, IL6
32hepatitis b30.2MMP3
33multiple sclerosis30.2LTA, IL10, IL6, MMP8, MMP12, MMP19
34gingivitis30.2MMP1, MMP8, MMP13, IL1A
35bronchiolitis obliterans30.2MMP8
36systemic scleroderma30.2IL1A, MMP3, MMP12, MMP1, PTPN22, SERPINH1
37myeloma30.2MMP8, IL6, LTA
38kawasaki disease30.2MMP9, MMP3
39sarcoma30.2MMP11
40leishmaniasis30.2IL10
41toxic shock syndrome30.2LTA
42inflammatory bowel disease30.2LTA, IL10, IL6, MMP13, MMP3, MMP1
43aggressive periodontitis30.1IL1A, MMP8, MMP1
44celiac disease30.1MMP12, PTPN22
45hypertension30.1MMP9
46pulmonary fibrosis30.1MMP13, MMP2, MMP1, MMP9, SERPINH1
47pancreatitis30.1IL6, IL10
48sarcoidosis30.1IL1A, LTA
49keratitis30.1MMP9, MMP2
50lymphopenia30.1IL6, PTPN22, IL10

Graphical network of the top 20 diseases related to Arthritis:



Diseases related to arthritis

Clinical Features for Arthritis

About this section

Drugs & Therapeutics for Arthritis

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arthritis

Drug clinical trials:

Search ClinicalTrials for Arthritis

Search NIH Clinical Center for Arthritis

Search CenterWatch for Arthritis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Arthritis

About this section

Anatomical Context for Arthritis

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Arthritis:

32
Bone, T cells, Monocytes, Endothelial, Skin, B cells, Lung, Testes, Bone marrow, Eye, Heart, Myeloid, Liver, Thyroid, Pituitary, Whole blood, Kidney, Breast, Lymph node, Spleen, Spinal cord, Tonsil, Colon, Nk cells, Salivary gland, Brain, Tongue, Thymus, Small intestine, Cervix, Prostate, Placenta, Retina, Smooth muscle, Skeletal muscle

FMA organs/tissues related to Arthritis:

14
Skin over the joint, Joint

Animal Models for Arthritis or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Arthritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.1IL6, IL1A, IL10, LTA, BST1, MMP3
2MP:000538512.5SERPINH1, LTA, IL10, IL1A, MMP15, MMP13
3MP:000537812.5LTA, IL10, IL6, MMP15, MMP13, MMP2
4MP:000537612.0LTA, MMP13, MMP12, MMP19, MMP11, MMP17
5MP:000538811.8LTA, IL6, MMP10, MMP2, MMP9, SERPINH1
6MP:000200611.6IL10, IL6, MMP8, MMP19, MMP11, MMP9
7MP:000539011.5IL6, MMP13, MMP3, SERPINH1, LTA

Publications for Arthritis

About this section
Sources:
50PubMed
See all sources

Articles related to Arthritis:

(show top 50)    (show all 11128)
idTitleAuthorsYear
1
Septic Arthritis caused by Group A Streptococcus in Newborn: An Unusual Presentation. (23905122)
2013
2
Osteoporosis in rheumatoid arthritis. (24340522)
2013
3
Rheumatoid arthritis: Testing the inflammation-insulin resistance link in clinical trials. (24247367)
2013
4
Incremental effects of comorbidity on quality of life in patients with psoriatic arthritis. (23772076)
2013
5
CD56+ monocytes have a dysregulated cytokine response to lipopolysaccharide and accumulate in rheumatoid arthritis and immunosenescence. (24286519)
2013
6
Indirect comparison of etanercept, infliximab, and adalumimab for psoriatic arthritis: mixed treatment comparison using placebo as common comparator. (22005889)
2012
7
The level of serum visfatin (PBEF) is associated with total number of B cells in patients with rheumatoid arthritis and decreases following B cell depletion therapy. (21524918)
2011
8
Reactive arthritis induced by tonsillitis: a type of 'focal infection'. (21865696)
2011
9
Minimally invasive washout of the shoulder for septic arthritis in children: a new technique. (21929923)
2011
10
Mucin from rheumatoid arthritis synovial fluid enhances interleukin-6 production by human peripheral blood mononuclear cells. (21195737)
2011
11
Clinical and radiological outcomes of postoperative septic arthritis after anterior cruciate ligament reconstruction. (20358332)
2010
12
Daptomycin in synovial fluid during treatment of methicillin-resistant Staphylococcus aureus septic arthritis. (20382723)
2010
13
Tocilizumab for the treatment of rheumatoid arthritis. (20477048)
2008
14
A role for the aryl hydrocarbon receptor and the dioxin TCDD in rheumatoid arthritis. (18617548)
2008
15
A novel predictor of clinical response to methotrexate in patients with rheumatoid arthritis: a pilot study of in vitro T cell cytokine suppression. (18464312)
2008
16
Pharmacogenetic study of 5,10-methylenetetrahydrofolate reductase C677T and thymidylate synthase 3R/2R gene polymorphisms and methotrexate-related toxicity in Chinese Han patients with inflammatory arthritis. (18621970)
2008
17
Disseminated cryptococcosis initially presenting as cellulitis in a rheumatoid arthritis patient. (17591585)
2007
18
Cysteine and serine proteases of synovial tissue in rheumatoid arthritis and osteoarthritis. (17963167)
2007
19
Combined technique for draining septic arthritis of the pediatric hip. (17461400)
2007
20
Drug Therapy for Psoriatic Arthritis in Adults: Comparative Effectiveness (23285485)
2007
21
Development of an ex vivo cellular model of rheumatoid arthritis: critical role of CD14-positive monocyte/macrophages in the development of pannus tissue. (17763413)
2007
22
Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells. (16410834)
2006
23
Functional characterization of a soluble gp130 isoform and its therapeutic capacity in an experimental model of inflammatory arthritis. (16646038)
2006
24
Natural resistance-associated macrophage protein 1 gene polymorphisms in rheumatoid arthritis. (16125248)
2006
25
PSORS2 markers are not associated with psoriatic arthritis in the Italian population. (16733365)
2006
26
Frequency of anti-hsp60, -65 and -70 antibodies in sera of patients with juvenile idiopathic arthritis. (16934956)
2006
27
Hypersensitivity reaction against influenza vaccine in a patient with rheumatoid arthritis after the initiation of etanercept injections. (17039318)
2006
28
Synovial fluid leukocyte apoptosis is inhibited in patients with very early rheumatoid arthritis. (16859518)
2006
29
Deficient expression of interleukin-10 receptor alpha chain in rheumatoid arthritis synovium: limitation of animal models of inflammation. (16200606)
2005
30
Cytokine and chemokine receptor profile of peripheral blood mononuclear cells during treatment with infliximab in patients with active rheumatoid arthritis. (15140775)
2004
31
Simultaneous, clonally identical T cell expansion in tonsil and synovium in a patient with rheumatoid arthritis and chronic tonsillitis. (13130467)
2003
32
Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritis. (11673556)
2001
33
Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines. (11037875)
2000
34
Fibroblast biology. Development and differentiation of synovial fibroblasts in arthritis. (11094446)
2000
35
Bacillus Calmette-GuAcrin induced reactive arthritis. (10405959)
1999
36
Rheumatoid arthritis associated with renal amyloidosis and crescentic glomerulonephritis. (9510410)
1998
37
Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2). (9870877)
1998
38
Soluble interleukin-2 receptor and interleukin-6 levels: evaluation during cyclosporin A and methotrexate treatment in psoriatic arthritis. (9586691)
1998
39
Inflammatory cytokines and cytokine antagonists in whole blood cultures of patients with systemic juvenile chronic arthritis. (9651086)
1998
40
The matrix metalloproteinase RASI-1 is expressed in synovial blood vessels of a rheumatoid arthritis patient. (9232430)
1997
41
Arthritis associated with circulating immune complexes following administration of intravenous immunoglobulin therapy in a patient with chronic inflammatory demyelinating polyneuropathy. (8926503)
1996
42
C3b receptor (CR1) genomic polymorphism in rheumatoid arthritis. Low receptor levels on erythrocytes are an acquired phenomenon. (7897264)
1994
43
The putative oncoprotein DEK, part of a chimera protein associated with acute myeloid leukaemia, is an autoantigen in juvenile rheumatoid arthritis. (8252804)
1993
44
Severe progressive erosive arthritis in multicentric reticulohistiocytosis: possible involvement of cytokines in synovial proliferation. (1464883)
1992
45
Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis? (1531747)
1992
46
IL-1 receptor antagonist protein production and gene expression in rheumatoid arthritis and osteoarthritis synovium. (1386092)
1992
47
Inhibition of 5-lipoxygenase product formation and polymorphonuclear cell degranulation by tenidap sodium in patients with rheumatoid arthritis. (1847289)
1991
48
Treatment of rheumatoid arthritis with an anti-CD4 monoclonal antibody. (1994909)
1991
49
Synovitis in angioimmunoblastic lymphadenopathy with dysproteinemia simulating rheumatoid arthritis. (2328036)
1990
50
Oral low-dose methotrexate (MTX) to be efficient in refractory rheumatoid arthritis and adult-onset Still's disease. (2741938)
1989

Genetic Variations for Arthritis

About this section

Expression for genes affiliated with Arthritis

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arthritis

Search GEO for disease gene expression data for Arthritis.

Pathways for genes affiliated with Arthritis

About this section
Sources:
53Reactome, 37NCBI BioSystems Database, 51QIAGEN, 12EMD Millipore, 29KEGG, 52R&D Systems
See all sources

Pathways related to Arthritis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
13.2MMP10, MMP2, MMP8, MMP12, MMP19, MMP11
2
Hide members
13.0MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
3
Hide members
12.8MMP10, MMP3, MMP13, IL6, MMP2, MMP8
4
Cell adhesion ECM remodeling
Hide members
12.8MMP10, MMP2, MMP8, MMP12, MMP19, MMP17
5
Hide members
12.6MMP2, MMP10, MMP3, MMP13, MMP8, MMP12
6
Hide members
12.6MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
711.7IL6, MMP2, MMP12, MMP11, MMP1, MMP9
811.3IL6, MMP2, MMP1, MMP9
911.3LTA, IL6, MMP3, MMP9
1011.3IL6, IL1A, IL10, LTA
11
Hide members
11.3IL6, IL1A, IL10, LTA
12
Cell adhesion Cell-matrix glycoconjugates
Hide members
11.1MMP3, MMP1, MMP9
13
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.1MMP1, MMP3, MMP13
1411.1MMP13, MMP9, SERPINH1
1511.1MMP9, MMP2, IL6
1611.1MMP9, MMP2, IL6
17
Hide members
11.1MMP2, MMP3, MMP13
1811.1MMP13, MMP2, MMP9
1911.1IL6, IL1A, IL10
2011.1IL10, IL1A, IL6
21
Hide members
11.1LTA, IL10, IL6
22
Hide members
10.9PTPN22, LTA

Compounds for genes affiliated with Arthritis

About this section
Sources:
44Novoseek, 49PharmGKB, 11DrugBank, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 2BitterDB
See all sources

Compounds related to Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1vegf4413.9SERPINH1, MMP9, MMP1, LTA, IL10, IL1A
2calcium44 49 11 2416.8MMP9, MMP13, MMP15, MMP8, BST1, MMP3
3gi 254023x5913.5MMP10, MMP2, MMP8, MMP12, MMP19, MMP11
4gm 60015913.5MMP10, MMP2, MMP8, MMP12, MMP11, MMP17
5marimastat44 59 1115.5MMP11, MMP19, MMP15, MMP13, MMP3, MMP10
6batimastat44 59 1115.5MMP1, MMP17, MMP11, MMP19, MMP12, MMP8
7uk 3833675913.5MMP15, MMP1, MMP17, MMP13, MMP3, MMP10
8retinoic acid44 2414.2LTA, BST1, MMP8, MMP9, MMP11, MMP1
9serine4412.9MMP3, MMP1, MMP12, LTA, IL1A, MMP13
1012-o-tetradecanoylphorbol 13-acetate4412.8MMP1, LTA, IL1A, MMP13, MMP3, MMP10
11genistein44 28 59 2 11 2417.8MMP8, MMP2, MMP3, IL6, IL1A, MMP12
12tgf beta14412.6MMP13, IL6, MMP3, MMP2, MMP1, MMP9
13hyaluronic acid44 2413.6IL1A, LTA, IL6, MMP13, MMP2, MMP1
14sb 20358044 5913.6IL1A, MMP1, MMP2, MMP3, MMP9, MMP13
15paraffin4412.5MMP3, MMP1, MMP9, MMP11, IL10, LTA
16hydroxamate4412.4MMP9, MMP1, MMP12, MMP8, MMP2, MMP3
17progesterone44 59 28 11 2416.4LTA, IL1A, MMP2, MMP11, MMP15, MMP1
18prednisolone44 28 1114.4IL6, MMP1, MMP2, MMP3, MMP13, IL10
19herbimycin a44 5913.3IL6, MMP13, MMP1, LTA, MMP2, MMP9
20curcumin4412.3IL6, MMP13, MMP3, MMP1, MMP9, IL1A
21etanercept44 49 1114.2MMP1, LTA, MMP12, MMP3, IL6, IL10
22doxycycline44 1113.1MMP8, MMP1, MMP9, MMP3, MMP13, MMP2
23tetracycline44 1113.1MMP9, MMP1, MMP8, MMP2, MMP13, IL1A
24oligonucleotide4412.1MMP1, MMP11, MMP12, SERPINH1, MMP10, MMP13
25glycosaminoglycan4412.1MMP13, IL1A, MMP3, MMP8, MMP1, MMP9
26lactate4412.0MMP9, IL6, MMP3, MMP2, MMP8, MMP1
27clodronate44 49 1113.9MMP13, IL10, MMP1, MMP8, IL6
28alendronate44 49 1113.9MMP8, MMP2, MMP13, MMP1, MMP3
29dexamethasone44 49 28 1114.8MMP12, LTA, MMP9, IL6, MMP13
30infliximab44 49 1113.8LTA, IL10, IL6, MMP3, MMP1
31ibuprofen44 28 49 11 2415.8MMP1, MMP2, IL6, IL10, MMP3
32(4-aminophenyl)mercuric acetate4411.8MMP8, MMP10, MMP13, MMP3
33methotrexate44 49 1113.7MMP1, MMP3, MMP2, IL6, IL10, MMP9
34matrigel4411.7MMP13, MMP3, MMP10, MMP1
35cyclosporin a44 28 5913.7SERPINH1, MMP8, MMP1, LTA
36pdtc4411.7IL1A, MMP9, MMP1, MMP2, IL6
37ilomastat4411.7MMP2, MMP9, MMP1, MMP3
38latanoprost44 1112.6MMP1, MMP3, MMP2, MMP9
39pravastatin44 49 28 11 2415.6IL1A, MMP3, MMP1, IL6, MMP2
40aprotinin44 1112.5MMP2, MMP13, MMP1
41rantes4411.5IL6, IL1A, LTA
42pentoxifylline44 1112.5MMP2, LTA, MMP1
43cgs-27023a4411.4MMP2, MMP1, MMP9
44prostaglandin4411.3MMP1, MMP3, IL1A
45pge24411.3MMP9, MMP2
46thps4411.3MMP13, MMP2, MMP1
47n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1112.2MMP3, MMP10, MMP12
48ivig4411.1IL1A
49cycloheximide4411.0LTA
50zoledronic acid4411.0MMP9, MMP1, IL6, MMP2

GO Terms for genes affiliated with Arthritis

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557613.0MMP10, MMP3, MMP13, IL6, MMP2, MMP8
2proteinaceous extracellular matrixGO:00557812.7MMP9, MMP13, MMP3, MMP10, MMP2, MMP8
3extracellular spaceGO:00561512.5IL6, IL1A, IL10, LTA, MMP13, MMP3

Biological processes related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019812.9MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
2collagen catabolic processGO:03057412.9MMP15, MMP9, MMP13, MMP3, MMP10, MMP2
3extracellular matrix disassemblyGO:02261712.8MMP3, MMP10, MMP2, MMP8, MMP12, MMP19
4proteolysisGO:00650812.7MMP3, MMP10, MMP2, MMP8, MMP12, MMP19
5humoral immune responseGO:00695911.1IL6, LTA, BST1

Molecular functions related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422213.0MMP9, MMP15, MMP13, MMP3, MMP10, MMP2
2zinc ion bindingGO:00827012.9MMP2, MMP10, MMP3, MMP13, MMP15, MMP8
3calcium ion bindingGO:00550912.3MMP15, MMP13, MMP3, MMP10, MMP8, MMP12
4cytokine activityGO:00512511.3IL6, IL1A, IL10, LTA

Products for genes affiliated with Arthritis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arthritis

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet