MCID: ART022
MIFTS: 75

Arthritis malady

Summaries for Arthritis

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 64Wikipedia, 33MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
MedlinePlus:34 If you feel pain and stiffness in your body or have trouble moving around, you might have arthritis. most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. over time, a swollen joint can become severely damaged. some kinds of arthritis can also cause problems in your organs, such as your eyes or skin. types of arthritis include osteoarthritis is the most common type of arthritis. it's often related to aging or to an injury. autoimmune arthritis happens when your body's immune system attacks healthy cells in your body by mistake. rheumatoid arthritis is the most common form of this kind of arthritis. juvenile rheumatoid arthritis is a form of the disease that happens in children. infectious arthritis is an infection that has spread from another part of the body to the joint. psoriatic arthritis affects people with psoriasis. gout is a painful type of arthritis that happens when too much uric acid builds up in the body. it often starts in the big toe. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Arthritis, also known as inflammatory joint disease, is related to psoriatic arthritis and juvenile rheumatoid arthritis. An important gene associated with Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Collagen biosynthesis and modifying enzymes and Matrix Metalloproteinases. The drugs meclofenamate sodium and salsalate and the compounds vegf and calcium have been mentioned in the context of this disorder. Affiliated tissues include joint, skin over the joint and skin, and related mouse phenotypes are immune system and cardiovascular system.

Disease Ontology:8 A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located in joint and/or redness located in skin over the joint.

CDC:3 Arthritis is the most common cause of disability in the United States, limiting the activities of nearly 21 million adults. The CDC Arthritis Program is working to improve the quality of life for people affected by arthritis and other rheumatic conditions by working with states and other partners to increase awareness about appropriate arthritis self management activities and expanding the reach of programs proven to improve the quality of life for people with arthritis. See Arthritis Spotlights on Science >>

Wikipedia:64 Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint... more...

Aliases & Classifications for Arthritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

arthritis 8 10 45 34 61
inflammatory joint disease 45 61
inflammatory disorder of joint 8


External Ids:

Disease Ontology8 DOID:848
NCIt40 C2883
MeSH35 D001168
ICD1025 M13.8, M13.9

Related Diseases for Arthritis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Arthritis family:

transient arthritis

Diseases related to Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 963)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis31.7MMP1, IL1A, PTPN22, MMP3
2juvenile rheumatoid arthritis31.6LTA, IL1A, IL6
3osteoarthritis31.3MMP9, MMP1, IL6, IL1A, MMP13, LTA
4systemic lupus erythematosus31.2MMP3, IL6, SERPINH1, IL10, LTA, PTPN22
5synovitis31.1IL1A, IL6, MMP13, MMP1, MMP11, MMP8
6uveitis30.9IL1A, LTA, IL10
7tuberculosis30.8IL10
8atherosclerosis30.7MMP3, MMP9, MMP1, MMP12, MMP8, MMP2
9osteoporosis30.7MMP13, IL6, MMP3, MMP8
10arthropathy30.6MMP13, MMP1, MMP3
11hepatitis c30.5IL10
12vascular disease30.4MMP2, IL10, IL1A, IL6, MMP3
13asthma30.4MMP8, IL10, MMP3, MMP9, MMP12
14ulcerative colitis30.3LTA, MMP13, IL10, IL6, IL1A, MMP1
15thyroiditis30.3PTPN22
16nephritis30.2LTA
17bronchiolitis obliterans30.2MMP8
18systemic scleroderma30.2MMP12, PTPN22, MMP3, IL1A, SERPINH1, MMP1
19kawasaki disease30.2MMP3, MMP9
20toxic shock syndrome30.2LTA
21aggressive periodontitis30.2MMP1, MMP8, IL1A
22sepsis30.2LTA, IL6, IL10, IL1A
23celiac disease30.2PTPN22, MMP12
24lupus nephritis30.1IL10, LTA
25visceral leishmaniasis30.1LTA, IL10
26graves' disease30.0IL1A, PTPN22, LTA
27kaposi's sarcoma30.0IL6
28thrombocytopenia29.9IL1A, IL6
29hepatitis b29.9MMP3
30vitiligo29.9PTPN22
31septic shock29.9LTA, IL10, IL1A, IL6
32bronchiectasis29.8MMP8
33bladder carcinoma29.8LTA
34adenocarcinoma29.7MMP15, MMP13, MMP9, MMP11, MMP12, MMP2
35pulmonary disease, chronic obstructive29.7IL6, MMP8, MMP1, MMP9, MMP12
36atopy29.7LTA, IL10
37acute pancreatitis29.7IL6, IL10
38pemphigus vulgaris29.7IL1A
39alopecia areata29.7IL1A
40coronary artery disease,29.5IL6, MMP13, MMP12, MMP3, MMP9
41idiopathic pulmonary fibrosis29.5SERPINH1, MMP1, MMP9, IL1A
42fibromatosis, gingival29.5SERPINH1, MMP1, MMP2
43squamous cell carcinoma29.5MMP12, MMP19, MMP10
44acute myocardial infarction29.5MMP8, MMP9
45bacterial vaginosis29.5SERPINH1, IL1A
46thoracic aortic aneurysm29.5MMP2, MMP1
47adenoma29.5MMP11
48lepromatous leprosy29.5LTA, IL10
49adult t-cell leukemia29.5SERPINH1
50hypertensive heart disease29.5MMP1

Graphical network of the top 20 diseases related to Arthritis:



Diseases related to arthritis

Clinical Features for Arthritis

Drugs & Therapeutics for Arthritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arthritis

Drug clinical trials:

Search ClinicalTrials for Arthritis

Search NIH Clinical Center for Arthritis

Search CenterWatch for Arthritis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Arthritis

Anatomical Context for Arthritis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Arthritis:

33
Skin, Liver, Tongue, Spinal cord, Brain, Kidney, Lymph node, Lung, Spleen, Bone marrow, Whole blood, Thymus, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Thyroid, Salivary gland, Adrenal gland, Breast, Placenta, Prostate, Cervix, Tonsil, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Fetal liver, Fetal lung, Fetal thyroid, Pancreatic islet, Pituitary

FMA organs/tissues related to Arthritis:

14
Joint, Skin over the joint

Animal Models for Arthritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Arthritis

Sources:
51PubMed
See all sources

Articles related to Arthritis:

(show top 50)    (show all 11130)
idTitleAuthorsYear
1
Age impacts on the independent relationships of leptin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: a cross-sectional study. (24399454)
2014
2
Preclinical to clinical translation of tofacitinib, a janus kinase inhibitor, in rheumatoid arthritis. (24218541)
2014
3
The concomitant use of meloxicam and methotrexate does not clearly increase the risk of silent kidney and liver damages in patients with rheumatoid arthritis. (24362788)
2013
4
Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions. (23144698)
2012
5
Increased levels of interleukin-33 associated with bone erosion and interstitial lung diseases in patients with rheumatoid arthritis. (22239947)
2012
6
Rheumatoid arthritis and pneumoconiosis. (22550214)
2012
7
Chronic calcium pyrophosphate crystal inflammatory arthritis induced by extreme hypomagnesemia in short bowel syndrome. (22998213)
2012
8
Sweet's syndrome in a patient with rheumatoid arthritis, SjAPgren's syndrome and lymph node tuberculosis. (22714601)
2011
9
Septic arthritis due to Cellulosimicrobium cellulans. (21998421)
2011
10
Salmonella enteritidis bacteremia with septic arthritis of the sacroiliac joint in a patient with systemic lupus erythematosus: case report and review of the literature. (22746014)
2011
11
MRI evaluation of the temporomandibular joints in juvenile rheumatoid arthritis: a retrospective review. (24059900)
2011
12
Chikungunya virus arthritis in adult wild-type mice. (20519386)
2010
13
Specifically modified osteopontin in rheumatoid arthritis fibroblast-like synoviocytes supports interaction with B cells and enhances production of interleukin-6. (19950274)
2009
14
Cytokine gene polymorphisms associated with rheumatoid arthritis and periodontitis in Japanese adults. (19405833)
2009
15
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis. (19116933)
2009
16
Medical treatment of juvenile idiopathic arthritis]. (18831464)
2008
17
Antibodies against mutated citrullinated vimentin are a better predictor of disease activity at 24 months in early rheumatoid arthritis than antibodies against cyclic citrullinated peptides. (18398946)
2008
18
Alopecia areata universalis during treatment of rheumatoid arthritis with anti-TNF-alpha antibody (adalimumab). (18849606)
2008
19
Association of allograft inflammatory factor-1 gene polymorphism with rheumatoid arthritis. (18721278)
2008
20
GDF5 Polymorphism associated with osteoarthritis: risk for rheumatoid arthritis. (18697781)
2008
21
Mutual antagonistic relationship between prostaglandin E(2) and IFN-gamma: Implications for rheumatoid arthritis. (18506884)
2008
22
The inflammatory disease-associated variants in IL12B and IL23R are not associated with rheumatoid arthritis. (18512797)
2008
23
Generalized pustulosis induced by adalimumab in a patient with rheumatoid arthritis - a therapeutic challenge. (18986481)
2008
24
HLA-DRB1 and persistent chronic inflammation contribute to cardiovascular events and cardiovascular mortality in patients with rheumatoid arthritis. (17266100)
2007
25
Apoptosis is not the major death mechanism induced by celecoxib on rheumatoid arthritis synovial fibroblasts. (18076767)
2007
26
Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in lewis rats by suppression of tumor necrosis factor-alpha in T lymphocytes and macrophages. (17065367)
2007
27
Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis. (18084706)
2007
28
Significance of citrullinated collagen type II and its antibodies in rheumatoid arthritis]. (17156630)
2006
29
The T cells specific for the carboxyl-terminal determinants of self (rat) heat-shock protein 65 escape tolerance induction and are involved in regulation of autoimmune arthritis. (14978079)
2004
30
RANK signaling is not required for TNFalpha-mediated increase in CD11(hi) osteoclast precursors but is essential for mature osteoclast formation in TNFalpha-mediated inflammatory arthritis. (14969390)
2004
31
Differential effects of leflunomide and methotrexate on cytokine production in rheumatoid arthritis. (15115713)
2004
32
Bone loss in inflammatory arthritis: mechanisms and treatment strategies. (15201606)
2004
33
HLA-B27-associated reactive arthritis: pathogenetic and clinical considerations. (15084505)
2004
34
Manganese superoxide dismutase gene polymorphisms in psoriatic arthritis. (15266664)
2003-2004
35
Spironolactone inhibits production of proinflammatory cytokines, including tumour necrosis factor-alpha and interferon-gamma, and has potential in the treatment of arthritis. (12974768)
2003
36
Dynamic changes in cytokine levels in serum and synovial fluid following filtration leukocytapheresis therapy in patients with rheumatoid arthritis. (11746532)
2001
37
Multipoint linkage analysis of a candidate gene locus in rheumatoid arthritis demonstrates significant evidence of linkage and association with the corticotropin-releasing hormone genomic region. (10943856)
2000
38
Effects of combinations of anti-rheumatic drugs on the production of vascular endothelial growth factor and basic fibroblast growth factor in cultured synoviocytes and patients with rheumatoid arthritis. (11085806)
2000
39
Classification criteria for reactive arthritis. (10381032)
1999
40
Intensified-dose (4 gm/m2) cyclophosphamide and granulocyte colony-stimulating factor administration for hematopoietic stem cell mobilization in refractory rheumatoid arthritis. (10555020)
1999
41
Linkage of cytokine genes to rheumatoid arthritis. Evidence of genetic heterogeneity. (9771211)
1998
42
Immunohistochemical detection of factor XIIIa and factor XIIIs in synovial membranes of patients with rheumatoid arthritis or osteoarthritis. (8783420)
1996
43
Blood prolactin under the effect of protirelin in spondylarthropathies. Treatment trial of 4 cases of reactive arthritis and 2 cases of psoriatic arthritis with bromocriptine]. (8763085)
1996
44
Posttraumatic reflex sympathetic dystrophy anteceding inverse psoriasis and psoriatic arthritis. (7791184)
1995
45
Interleukin-2 production in early rheumatoid arthritis. (8358999)
1993
46
Sex hormones and bone metabolism in postmenopausal rheumatoid arthritis treated with two different glucocorticoids. (1294736)
1992
47
T cell reactivity to an epitope of the mycobacterial 65-kDa heat-shock protein (hsp 65) corresponds with arthritis susceptibility in rats and is regulated by hsp 65-specific cellular responses. (1709871)
1991
48
Drug treatment of progressive rheumatoid arthritis. (2029152)
1991
49
DQw7 and the C4B null allele in rheumatoid arthritis and Felty's syndrome. (2270969)
1990
50
Whipple disease. Occurrence in a 76-year-old man with a 20-year prodrome of arthritis. (48564)
1975

Genetic Variations for Arthritis

Expression for genes affiliated with Arthritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arthritis

Search GEO for disease gene expression data for Arthritis.

Pathways for genes affiliated with Arthritis

Sources:
54Reactome, 38NCBI BioSystems Database, 52QIAGEN, 12EMD Millipore, 30KEGG, 53R&D Systems
See all sources

Pathways related to Arthritis according to GeneCards/GeneDecks:

(show all 22)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
13.2MMP13, MMP3, MMP10, MMP2, MMP8, MMP12
2
Hide members
13.0MMP12, MMP15, MMP13, MMP3, MMP10, MMP2
3
Hide members
12.8MMP2, MMP9, MMP1, IL6, MMP19, MMP11
4
Cell adhesion ECM remodeling
Hide members
12.8MMP15, MMP13, MMP12, MMP19, MMP17, MMP9
5
Hide members
12.6MMP3, MMP10, MMP12, MMP2, MMP13, MMP8
6
Hide members
12.6MMP8, MMP13, MMP15, MMP3, MMP10, MMP11
711.7MMP1, MMP9, MMP11, MMP12, IL6, MMP2
811.3MMP1, MMP9, IL6, MMP2
911.3MMP3, IL6, LTA, MMP9
1011.3IL10, IL6, IL1A, LTA
11
Hide members
11.3IL1A, LTA, IL10, IL6
12
Cell adhesion Cell-matrix glycoconjugates
Hide members
11.1MMP9, MMP1, MMP3
13
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.1MMP1, MMP3, MMP13
1411.1SERPINH1, MMP13, MMP9
1511.1IL6, MMP9, MMP2
1611.1MMP9, MMP2, IL6
17
Hide members
11.1MMP3, MMP13, MMP2
1811.1MMP2, MMP9, MMP13
1911.1IL1A, IL6, IL10
2011.1IL1A, IL10, IL6
21
Hide members
11.1IL6, LTA, IL10
22
Hide members
10.9LTA, PTPN22

Compounds for genes affiliated with Arthritis

Sources:
45Novoseek, 50PharmGKB, 11DrugBank, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 2BitterDB
See all sources

Compounds related to Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 140)
idCompoundScoreTop Affiliating Genes
1vegf4513.9SERPINH1, MMP9, MMP1, LTA, IL10, IL1A
2calcium45 50 11 2416.8MMP9, MMP13, MMP15, MMP8, BST1, MMP3
3gi 254023x6013.5MMP10, MMP2, MMP8, MMP12, MMP19, MMP11
4gm 60016013.5MMP10, MMP2, MMP8, MMP12, MMP11, MMP17
5marimastat45 60 1115.5MMP11, MMP19, MMP15, MMP13, MMP3, MMP10
6batimastat45 60 1115.5MMP1, MMP17, MMP11, MMP19, MMP12, MMP8
7uk 3833676013.5MMP15, MMP1, MMP17, MMP13, MMP3, MMP10
8retinoic acid45 2414.2LTA, BST1, MMP8, MMP9, MMP11, MMP1
9serine4512.9MMP3, MMP1, MMP12, LTA, IL1A, MMP13
1012-o-tetradecanoylphorbol 13-acetate4512.8MMP1, LTA, IL1A, MMP13, MMP3, MMP10
11genistein45 29 60 2 11 2417.8MMP8, MMP2, MMP3, IL6, IL1A, MMP12
12tgf beta14512.6MMP13, IL6, MMP3, MMP2, MMP1, MMP9
13hyaluronic acid45 2413.6IL1A, LTA, IL6, MMP13, MMP2, MMP1
14sb 20358045 6013.6IL1A, MMP1, MMP2, MMP3, MMP9, MMP13
15paraffin4512.5MMP3, MMP1, MMP9, MMP11, IL10, LTA
16hydroxamate4512.4MMP9, MMP1, MMP12, MMP8, MMP2, MMP3
17progesterone45 60 29 11 2416.4LTA, IL1A, MMP2, MMP11, MMP15, MMP1
18prednisolone45 29 1114.4IL6, MMP1, MMP2, MMP3, MMP13, IL10
19herbimycin a45 6013.3IL6, MMP13, MMP1, LTA, MMP2, MMP9
20curcumin4512.3IL6, MMP13, MMP3, MMP1, MMP9, IL1A
21etanercept45 50 1114.2MMP1, LTA, MMP12, MMP3, IL6, IL10
22doxycycline45 1113.1MMP8, MMP1, MMP9, MMP3, MMP13, MMP2
23tetracycline45 1113.1MMP9, MMP1, MMP8, MMP2, MMP13, IL1A
24oligonucleotide4512.1MMP1, MMP11, MMP12, SERPINH1, MMP10, MMP13
25glycosaminoglycan4512.1MMP13, IL1A, MMP3, MMP8, MMP1, MMP9
26lactate4512.0MMP9, IL6, MMP3, MMP2, MMP8, MMP1
27clodronate45 50 1113.9MMP13, IL10, MMP1, MMP8, IL6
28alendronate45 50 1113.9MMP8, MMP2, MMP13, MMP1, MMP3
29dexamethasone45 50 29 1114.8MMP12, LTA, MMP9, IL6, MMP13
30infliximab45 50 1113.8LTA, IL10, IL6, MMP3, MMP1
31ibuprofen45 29 50 11 2415.8MMP1, MMP2, IL6, IL10, MMP3
32(4-aminophenyl)mercuric acetate4511.8MMP8, MMP10, MMP13, MMP3
33methotrexate45 50 1113.7MMP1, MMP3, MMP2, IL6, IL10, MMP9
34matrigel4511.7MMP13, MMP3, MMP10, MMP1
35cyclosporin a45 29 6013.7SERPINH1, MMP8, MMP1, LTA
36pdtc4511.7IL1A, MMP9, MMP1, MMP2, IL6
37ilomastat4511.7MMP2, MMP9, MMP1, MMP3
38latanoprost45 1112.6MMP1, MMP3, MMP2, MMP9
39pravastatin45 50 29 11 2415.6IL1A, MMP3, MMP1, IL6, MMP2
40aprotinin45 1112.5MMP2, MMP13, MMP1
41rantes4511.5IL6, IL1A, LTA
42pentoxifylline45 1112.5MMP2, LTA, MMP1
43cgs-27023a4511.4MMP2, MMP1, MMP9
44prostaglandin4511.3MMP1, MMP3, IL1A
45pge24511.3MMP9, MMP2
46thps4511.3MMP13, MMP2, MMP1
47n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid45 1112.2MMP3, MMP10, MMP12
48ivig4511.1IL1A
49cycloheximide4511.0LTA
50zoledronic acid4511.0MMP9, MMP1, IL6, MMP2

GO Terms for genes affiliated with Arthritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557613.0MMP1, MMP11, MMP19, MMP12, MMP8, MMP2
2proteinaceous extracellular matrixGO:00557812.7MMP12, MMP9, MMP1, MMP17, MMP11, MMP19
3extracellular spaceGO:00561512.5MMP9, IL10, IL1A, IL6, MMP13, MMP3

Biological processes related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019812.9MMP15, MMP13, MMP3, MMP10, MMP2, MMP8
2collagen catabolic processGO:03057412.9MMP15, MMP9, MMP13, MMP3, MMP10, MMP2
3extracellular matrix disassemblyGO:02261712.8MMP3, MMP10, MMP2, MMP8, MMP12, MMP19
4proteolysisGO:00650812.7MMP3, MMP10, MMP2, MMP8, MMP12, MMP19
5humoral immune responseGO:00695911.1IL6, LTA, BST1

Molecular functions related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422213.0MMP9, MMP15, MMP13, MMP3, MMP10, MMP2
2zinc ion bindingGO:00827012.9MMP2, MMP10, MMP3, MMP13, MMP15, MMP8
3calcium ion bindingGO:00550912.3MMP15, MMP13, MMP3, MMP10, MMP8, MMP12
4cytokine activityGO:00512511.3IL6, IL1A, IL10, LTA

Products for genes affiliated with Arthritis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arthritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet