MCID: ART022
MIFTS: 65

Arthritis malady

Bone diseases, Skin diseases categories

Aliases & Classifications for Arthritis

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Aliases & Descriptions for Arthritis:

Name: Arthritis 30 8 10 44 32 2 61
Inflammatory Joint Disease 44 61
 
Inflammatory Disorder of Joint 8


Classifications:



External Ids:

Disease Ontology8 DOID:848
NCIt39 C2883
MeSH33 D001168
ICD1025 M13.8, M13.9

Summaries for Arthritis

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MedlinePlus:32 If you feel pain and stiffness in your body or have trouble moving around, you might have arthritis. most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. over time, a swollen joint can become severely damaged. some kinds of arthritis can also cause problems in your organs, such as your eyes or skin. types of arthritis include osteoarthritis is the most common type of arthritis. it's often related to aging or to an injury. autoimmune arthritis happens when your body's immune system attacks healthy cells in your body by mistake. rheumatoid arthritis is the most common form of this kind of arthritis. juvenile rheumatoid arthritis is a form of the disease that happens in children. infectious arthritis is an infection that has spread from another part of the body to the joint. psoriatic arthritis affects people with psoriasis. gout is a painful type of arthritis that happens when too much uric acid builds up in the body. it often starts in the big toe. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards based summary: Arthritis, also known as inflammatory joint disease, is related to psoriatic arthritis and juvenile rheumatoid arthritis. An important gene associated with Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Syndecan-1-mediated signaling events and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs meclofenamate sodium and salsalate and the compounds ilomastat and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include joint, skin over the joint and bone, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located in joint and/or redness located in skin over the joint.

CDC:2 Arthritis affects 52.5 million U.S. adults, more than 1 in 5. It is the nation’s most common cause of disability. Learn more about arthritis, the proven ways to manage it and the resources available to public health professionals.

Wikipedia:64 Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint... more...

Related Diseases for Arthritis

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Diseases in the Arthritis family:

Transient Arthritis

Diseases related to Arthritis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 1030)
idRelated DiseaseScoreTop Affiliating Genes
1psoriatic arthritis32.5PTPN22, MMP3, MMP1, IL1A
2juvenile rheumatoid arthritis32.4LTA, IL1A, IL6
3rheumatoid arthritis32.3LTA, IL1A, IL6, IL10, MMP1, MMP19
4psoriasis31.9PTPN22, MMP19, IL10, IL6, IL1A, LTA
5systemic lupus erythematosus31.8PTPN22, SERPINH1, MMP3, IL10, IL6, LTA
6uveitis31.7IL10, IL1A, LTA
7synovitis31.7IL1A, IL6, MMP1, MMP8, MMP11, MMP3
8osteoarthritis31.6MMP13, MMP9, MMP12, MMP2, LTA, IL1A
9periodontitis31.6MMP9, MMP8, IL1A
10pneumonia31.6MMP12, MMP8, IL10, IL6
11arthropathy31.5MMP1, MMP3, MMP13
12osteoporosis31.4IL6, MMP8, MMP3, MMP13
13connective tissue disease31.4PTPN22, IL10, IL6
14periodontal disease31.2MMP2, MMP3, MMP1, IL6
15meningitis31.2IL6, MMP9
16gingivitis31.0MMP13, MMP8, MMP1, IL1A
17aggressive periodontitis31.0MMP8, MMP1, IL1A
18atherosclerosis31.0MMP9, MMP12, MMP2, MMP3, MMP10, MMP8
19asthma31.0MMP9, MMP12, MMP3, MMP8, IL10
20lymphopenia30.9PTPN22, IL10, IL6
21kawasaki disease30.9MMP3, MMP9
22pulmonary fibrosis30.9SERPINH1, MMP13, MMP9, MMP2, MMP1
23visceral leishmaniasis30.9LTA, IL10
24inflammatory bowel disease30.9PTPN22, MMP13, MMP3, MMP1, IL10, IL6
25ulcerative colitis30.8MMP13, MMP3, MMP1, IL10, IL6, IL1A
26vascular disease30.8MMP2, MMP3, IL10, IL6, IL1A
27tonsillitis30.8IL1A, LTA
28graves' disease30.7PTPN22, IL1A, LTA
29skin disease30.7IL1A, IL10, MMP1
30aneurysm30.7MMP9, MMP12, MMP2, MMP3, MMP8
31dermatitis herpetiformis30.7MMP12, MMP3
32atopic dermatitis30.6LTA, IL1A, IL10
33melanoma30.5MMP13, MMP9, MMP12, MMP2, MMP11, MMP1
34systemic scleroderma30.5PTPN22, SERPINH1, MMP12, MMP3, MMP1, IL1A
35breast cancer30.5MMP13, MMP9, MMP2, MMP3, MMP17, MMP11
36diverticulitis30.4MMP13
37thoracic aortic aneurysm30.4MMP2, MMP1
38tongue cancer30.4MMP9, MMP2, MMP8
39chorioamnionitis30.4IL6, MMP8, SERPINH1
40lepromatous leprosy30.3IL10, LTA
41bacterial vaginosis30.3SERPINH1, IL1A
42keratoconus30.2MMP2, MMP3, MMP10, MMP8, MMP1
43adenocarcinoma30.2MMP13, MMP9, MMP12, MMP2, MMP11, MMP10
44coronary artery disease30.1LTA, IL6, MMP8
45hepatocellular carcinoma30.1MMP9, MMP12, MMP2, MMP15, IL6
46septic arthritis11.1
47reactive arthritis11.1
48lupus erythematosus10.9
49spondylitis10.8
50systemic onset juvenile idiopathic arthritis10.8

Graphical network of the top 20 diseases related to Arthritis:



Diseases related to arthritis

Symptoms for Arthritis

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Drugs & Therapeutics for Arthritis

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Drug clinical trials:

Search ClinicalTrials for Arthritis

Search NIH Clinical Center for Arthritis

Inferred drug relations via UMLS61/NDF-RT40:

Genetic Tests for Arthritis

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Anatomical Context for Arthritis

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MalaCards organs/tissues related to Arthritis:

31
Bone, T cells, Monocytes, Endothelial, Skin, Neutrophil, B cells, Lung, Testes, Bone marrow, Eye, Heart, Myeloid, Thyroid, Liver, Whole blood, Pituitary, Kidney, Breast, Lymph node, Spleen, Spinal cord, Tonsil, Colon, Nk cells, Tongue, Brain, Salivary gland, Thymus, Small intestine, Retina, Smooth muscle, Skeletal muscle, Placenta, Prostate, Cervix

FMA organs/tissues related to Arthritis:

14
Joint, Skin over the joint

Animal Models for Arthritis or affiliated genes

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Publications for Arthritis

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Articles related to Arthritis:

(show top 50)    (show all 11437)
idTitleAuthorsYear
1
Association of neopterin as a marker of immune system activation and juvenile rheumatoid arthritis activity. (25727025)
2015
2
JAK/STAT/PKCI' molecular pathways in synovial fluid T lymphocytes reflect the in vivo T helper-17 expansion in psoriatic arthritis. (24385089)
2014
3
Does Socioeconomic Status Affect Outcomes in Early Inflammatory Arthritis? Data from a Canadian Multisite Suspected Rheumatoid Arthritis Inception Cohort. (25399388)
2014
4
Three Cases of Postoperative Septic Arthritis Caused by Mycobacterium conceptionense in Shoulder Joints of Immunocompetent Patients. (24391195)
2014
5
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
6
Periarticular bone gain at proximal interphalangeal joints and changes in bone turnover markers in response to tumor necrosis factor inhibitors in rheumatoid and psoriatic arthritis. (23457381)
2013
7
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
2013
8
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
9
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
2013
10
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
2013
11
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
12
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. (22513199)
2012
13
Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus. (22127698)
2011
14
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
2011
15
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
2010
16
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
17
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
2009
18
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
19
Defective phosphorylation of interleukin-18 receptor beta causes impaired natural killer cell function in systemic-onset juvenile idiopathic arthritis. (19714583)
2009
20
Update on the management of pain in arthritis and the use of cyclooxygenase-2 inhibitors. (19889287)
2009
21
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. (18311812)
2008
22
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
2008
23
Analysis of factors influencing prognosis in foals with septic arthritis. (21851707)
2008
24
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
25
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
26
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
2007
27
High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis. (17393419)
2007
28
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
2006
29
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
30
TNF inhibitors for inflammatory arthritis in New Zealand. (16258581)
2005
31
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
2004
32
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
33
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
34
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
2003
35
Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. (11824955)
2002
36
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
2001
37
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. (19078446)
2000
38
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
39
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
2000
40
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
41
Heat shock proteins as potential targets in the therapy of inflammatory arthritis. (9559974)
1998
42
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
43
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
1995
44
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
45
New directions for biological therapy in rheumatoid arthritis. (8199454)
1994
46
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
1994
47
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
1991
48
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
1984
49
Alkaptonuria, ochronosis, and arthritis in a Cypriot woman. (13938285)
1963
50
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959

Variations for Arthritis

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Expression for genes affiliated with Arthritis

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Search GEO for disease gene expression data for Arthritis.

Pathways for genes affiliated with Arthritis

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Pathways related to Arthritis according to GeneCards Suite gene sharing:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3MMP1, MMP9
210.3MMP2, MMP1
310.3MMP2, MMP9
410.2LTA, IL10
510.2MMP1, MMP9, MMP3
6
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells59
Oncostatin M Signaling Pathway36
10.2MMP13, MMP1, MMP3
710.2MMP9, MMP13, SERPINH1
810.2MMP9, MMP2, IL6
910.2MMP9, IL6, MMP2
1010.2MMP9, MMP2, MMP13
11
Show member pathways
IL23-mediated signaling events36
Immune response IL 10 signaling pathway59
Angiopoietin receptor Tie2-mediated signaling36
Development PDGF signaling via STATs and NF kB59
Development Angiopoietin Tie2 signaling59
10.2MMP2, IL6, IL10
12
Show member pathways
Apoptosis and survival TNFR1 signaling pathway59
TWEAK Signaling Pathway36
Apoptosis Modulation by HSP7036
HIV-1 Nef- Negative effector of Fas and TNF-alpha36
10.1LTA, IL6, MMP9
1310.1IL1A, IL6, MMP9
14
Show member pathways
IL27-mediated signaling events36
10.1LTA, IL6, IL10
1510.1IL10, IL6, IL1A
1610.1IL10, IL1A, IL6
1710.1IL1A, IL10, IL6
1810.1IL1A, IL6, IL10
19
Show member pathways
Transcription NF kB signaling pathway59
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response59
10.1IL1A, IL6, LTA
20
Show member pathways
10.1MMP9, MMP13, SERPINH1, MMP3
2110.1MMP2, MMP9, MMP1, IL6
2210.1MMP9, IL6, MMP2, MMP1
2310.1MMP3, MMP1, IL6, IL1A
2410.1LTA, MMP9, MMP3, IL6
25
Show member pathways
10.0IL10, LTA, IL1A, IL6
2610.0IL10, IL6, LTA, IL1A
27
Show member pathways
9.9IL1A, PTPN22, LTA, IL10, IL6
289.8MMP9, MMP12, MMP2, MMP11, MMP1, IL6
29
Show member pathways
9.3MMP12, MMP9, MMP2, MMP13, MMP3, MMP11
30
Show member pathways
9.2MMP13, MMP2, MMP8, MMP19, MMP1, MMP10
31
Show member pathways
Metalloproteases in connective tissue degradation
9.2MMP15, MMP2, MMP12, MMP9, MMP13, MMP1
32
Show member pathways
9.0MMP15, MMP1, MMP19, MMP8, MMP10, MMP11
33
Show member pathways
8.9MMP15, MMP1, MMP19, SERPINH1, MMP13, MMP9

Compounds for genes affiliated with Arthritis

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Compounds related to Arthritis according to GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1ilomastat4410.4MMP9, MMP1, MMP3, MMP2
2pentoxifylline44 1111.4IL10, IL6, IL1A, LTA
3latanoprost44 1111.4MMP9, MMP2, MMP3, MMP1
4clodronate44 50 1112.3MMP1, IL6, IL10, MMP8, MMP13
5cgs-27023a4410.3MMP9, MMP2, MMP1
6alendronate44 50 1112.3MMP8, MMP3, MMP2, MMP13, MMP1
7rantes4410.2IL1A, IL10, MMP1, MMP3, MMP9, MMP13
8etanercept44 50 1112.2MMP3, MMP12, LTA, IL6, IL10, MMP1
9doxycycline44 1111.2MMP13, MMP3, MMP9, MMP2, MMP8, MMP1
10hydroxamate4410.2MMP13, MMP9, MMP12, MMP2, MMP3, MMP1
11infliximab44 50 1112.2IL6, IL10, MMP1, LTA, MMP3
12ivig4410.2LTA, MMP2, IL1A, MMP9, IL6, IL10
13procollagen4410.2MMP3, MMP2, MMP9, SERPINH1, IL1A, MMP1
14(4-aminophenyl)mercuric acetate4410.2MMP13, MMP9, MMP2, MMP8, MMP1, MMP10
15ibuprofen44 28 50 24 1114.2IL10, MMP1, MMP2, IL6, MMP3
16tetracycline44 1111.2IL1A, MMP8, MMP2, MMP9, MMP1, MMP13
17glycosaminoglycan4410.1MMP13, MMP9, MMP3, MMP8, MMP1, IL1A
18aprotinin44 1111.1MMP13, MMP9, IL10, MMP2, MMP1, IL6
19n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid44 1111.1MMP10, MMP3, MMP12
20prednisolone44 28 1112.1MMP1, LTA, IL6, IL10, MMP13, MMP2
21egcg4410.1MMP3, MMP1, IL1A, MMP2, MMP13, MMP9
22pdtc4410.1MMP9, MMP2, MMP1, IL6, IL1A
23curcumin4410.1IL6, MMP13, MMP2, MMP3, MMP1, MMP9
24herbimycin a44 6011.1MMP9, MMP2, MMP13, MMP1, IL1A, LTA
25tgf beta14410.1LTA, IL6, MMP1, MMP3, MMP13, MMP2
26hyaluronic acid44 2411.0IL1A, MMP13, MMP9, MMP2, MMP3, LTA
27prostaglandin4410.0IL1A, MMP1, MMP9, MMP3, MMP13, IL6
28sb 20358044 6011.0IL1A, MMP13, MMP3, IL6, MMP2, MMP9
29matrigel4410.0MMP13, MMP9, MMP12, MMP2, MMP3, MMP10
30genistein44 28 60 1 24 1114.9MMP12, MMP13, MMP9, MMP2, MMP3, MMP8
31cyclosporin a44 28 6011.9IL1A, IL6, IL10, MMP1, MMP8, MMP3
32paraffin449.9MMP2, MMP9, LTA, IL10, MMP1, MMP13
33methotrexate50 44 1111.9IL10, IL6, MMP2, MMP9, MMP3, MMP1
34cycloheximide449.9MMP3, MMP9, MMP2, MMP1, IL10, IL6
3512-o-tetradecanoylphorbol 13-acetate449.9MMP13, MMP9, MMP2, MMP3, LTA, IL1A
36pge2449.8MMP2, MMP3, MMP9, MMP13, MMP8, MMP1
37dexamethasone44 50 28 1112.8MMP9, MMP12, MMP3, MMP1, IL10, IL6
38progesterone44 28 60 24 1113.8IL1A, MMP8, MMP2, MMP3, MMP11, LTA
39lactate449.7IL6, MMP1, MMP8, MMP3, MMP2, MMP9
40pravastatin44 50 28 24 1113.7MMP1, MMP2, MMP3, IL6, IL1A
41retinoic acid44 2410.6MMP13, LTA, MMP9, IL1A, BST1, IL6
42oligonucleotide449.6MMP13, MMP1, MMP8, SERPINH1, MMP10, LTA
43gi 254023x609.5MMP8, MMP19, MMP1, MMP15, MMP3, MMP13
44gm 6001609.5MMP19, MMP1, MMP15, MMP8, MMP10, MMP13
45serine449.5IL1A, MMP2, MMP1, MMP8, MMP10, MMP11
46marimastat44 60 1111.5MMP13, MMP9, MMP12, MMP2, MMP3, MMP17
47batimastat44 60 1111.5MMP15, MMP1, MMP19, MMP9, MMP12, MMP2
48uk 383367609.5MMP13, MMP12, MMP2, MMP3, MMP17, MMP11
49vegf449.3MMP8, MMP10, MMP11, MMP3, MMP2, MMP12
50calcium44 50 24 1112.2MMP3, LTA, BST1, MMP13, MMP9, MMP12

GO Terms for genes affiliated with Arthritis

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Cellular components related to Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.1MMP3, MMP2, MMP12, MMP9, MMP11, MMP10
2proteinaceous extracellular matrixGO:00055789.1MMP1, MMP13, MMP9, MMP12, MMP2, MMP3
3extracellular spaceGO:00056159.0MMP2, MMP9, MMP13, SERPINH1, MMP3, MMP10

Biological processes related to Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:004413010.2LTA, IL10
2humoral immune responseGO:00069599.8LTA, IL6, BST1
3proteolysisGO:00065089.4MMP13, MMP9, MMP12, MMP2, MMP3, MMP11
4collagen catabolic processGO:00305749.2MMP12, MMP2, MMP3, MMP11, MMP10, MMP8
5extracellular matrix disassemblyGO:00226179.2MMP13, MMP9, MMP12, MMP2, MMP3, MMP11
6extracellular matrix organizationGO:00301989.0MMP12, MMP2, MMP3, MMP11, MMP10, MMP8

Molecular functions related to Arthritis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.0LTA, IL1A, IL6, IL10
2metalloendopeptidase activityGO:00042229.0MMP15, MMP13, MMP9, MMP12, MMP2, MMP3
3calcium ion bindingGO:00055098.9MMP13, MMP12, MMP3, MMP17, MMP11, MMP10
4zinc ion bindingGO:00082708.9MMP3, MMP2, MMP12, MMP9, MMP13, MMP17

Sources for Arthritis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet