MCID: ART022
MIFTS: 75

Arthritis malady

Bone diseases, Skin diseases categories

Summaries for Arthritis

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Sources:
9Disease Ontology, 35MedlinePlus, 4CDC, 66Wikipedia, 34MalaCards
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MedlinePlus:35 If you feel pain and stiffness in your body or have trouble moving around, you might have arthritis. most kinds of arthritis cause pain and swelling in your joints. joints are places where two bones meet, such as your elbow or knee. over time, a swollen joint can become severely damaged. some kinds of arthritis can also cause problems in your organs, such as your eyes or skin. types of arthritis include osteoarthritis is the most common type of arthritis. it's often related to aging or to an injury. autoimmune arthritis happens when your body's immune system attacks healthy cells in your body by mistake. rheumatoid arthritis is the most common form of this kind of arthritis. juvenile rheumatoid arthritis is a form of the disease that happens in children. infectious arthritis is an infection that has spread from another part of the body to the joint. psoriatic arthritis affects people with psoriasis. gout is a painful type of arthritis that happens when too much uric acid builds up in the body. it often starts in the big toe. nih: national institute of arthritis and musculoskeletal and skin diseases

MalaCards: Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and psoriatic arthritis. An important gene associated with Arthritis is SERPINH1 (serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)), and among its related pathways are Syndecan-1-mediated signaling events and Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs meclofenamate sodium and salsalate and the compounds ilomastat and pentoxifylline have been mentioned in the context of this disorder. Affiliated tissues include skin over the joint, joint and bone, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:9 A bone inflammation disease that involves a response to irritation or injury, characterized by joint pain, swelling, stiffness located in joint and/or redness located in skin over the joint.

CDC:4 Arthritis affects 52.5 million U.S. adults, more than 1 in 5. It is the nation’s most common cause of disability. Learn more about arthritis, the proven ways to manage it and the resources available to public health professionals.

Wikipedia:66 Arthritis (from Greek arthro-, joint + -itis, inflammation; plural: arthritides) is a form of joint... more...

Aliases & Classifications for Arthritis

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Sources:
9Disease Ontology, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 41NCIt, 59SNOMED-CT, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases, Skin diseases


Aliases & Descriptions:

arthritis 9 11 46 35 63
inflammatory joint disease 46 63
inflammatory disorder of joint 9


External Ids:

Disease Ontology9 DOID:848
NCIt41 C2883
MeSH36 D001168
ICD1026 M13.8, M13.9

Related Diseases for Arthritis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Arthritis family:

Transient Arthritis

Diseases related to Arthritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 1041)
idRelated DiseaseScoreTop Affiliating Genes
1rheumatoid arthritis32.4MMP3, MMP11, MMP8, MMP19, MMP1, IL10
2psoriatic arthritis31.9PTPN22, MMP3, MMP1, IL1A
3juvenile rheumatoid arthritis31.8LTA, IL1A, IL6
4psoriasis31.4IL10, LTA, IL1A, MMP19, PTPN22, IL6
5osteoarthritis31.4MMP9, MMP12, MMP2, MMP3, MMP8, MMP1
6systemic lupus erythematosus31.4IL10, MMP3, PTPN22, IL6, LTA, SERPINH1
7synovitis31.3MMP13, MMP3, MMP11, MMP8, MMP1, IL6
8uveitis31.2IL1A, LTA, IL10
9pneumonia31.0IL6, IL10, MMP8, MMP12
10periodontitis31.0MMP9, IL1A, MMP8
11osteoporosis30.9MMP3, MMP13, MMP8, IL6
12arthropathy30.8MMP1, MMP3, MMP13
13atherosclerosis30.8MMP3, MMP10, MMP8, MMP1, MMP12, MMP2
14connective tissue disease30.8IL10, PTPN22, IL6
15periodontal disease30.6IL6, MMP1, MMP2, MMP3
16meningitis30.5MMP9, IL6
17diabetes mellitus30.5PTPN22, IL6, MMP3, MMP9
18asthma30.5MMP12, IL10, MMP8, MMP3, MMP9
19ulcerative colitis30.5IL1A, IL10, MMP13, MMP3, MMP1, LTA
20gingivitis30.4MMP13, MMP1, MMP8, IL1A
21aggressive periodontitis30.4IL1A, MMP1, MMP8
22multiple sclerosis30.4MMP9, MMP12, LTA, MMP8, IL6, IL10
23kawasaki disease30.4MMP3, MMP9
24sepsis30.4IL1A, IL10, LTA, IL6
25pulmonary fibrosis30.3SERPINH1, MMP1, MMP2, MMP9, MMP13
26vascular disease30.3MMP3, IL1A, IL6, MMP2, IL10
27skin disease30.3MMP1, IL10, IL1A
28visceral leishmaniasis30.3IL10, LTA
29lymphopenia30.3IL10, PTPN22, IL6
30inflammatory bowel disease30.3PTPN22, MMP13, MMP3, MMP1, IL10, IL6
31tonsillitis30.2IL1A, LTA
32graves' disease30.2IL1A, PTPN22, LTA
33melanoma30.2MMP13, MMP1, MMP11, MMP2, IL1A, MMP12
34aneurysm30.1MMP12, MMP2, MMP3, MMP8, MMP9
35systemic scleroderma30.1IL1A, PTPN22, SERPINH1, MMP3, MMP1, MMP12
36atopic dermatitis30.1LTA, IL10, IL1A
37encephalomyelitis30.1MMP12, LTA, IL10
38dermatitis herpetiformis30.1MMP3, MMP12
39breast cancer30.0MMP13, MMP2, MMP9, MMP1, MMP11, MMP17
40septic shock29.9LTA, IL6, IL10, IL1A
41cerebrovascular disease29.9MMP8, MMP13, MMP12, LTA
42bladder carcinoma29.9MMP9, MMP12, MMP2, MMP13, LTA
43adenocarcinoma29.8MMP15, MMP10, MMP11, MMP2, MMP13, MMP12
44diverticulitis29.7MMP13
45thoracic aortic aneurysm29.7MMP1, MMP2
46lepromatous leprosy29.7IL10, LTA
47bacterial vaginosis29.7IL1A, SERPINH1
48idiopathic pulmonary fibrosis29.7IL1A, MMP1, MMP9, SERPINH1
49keratoconus29.7MMP3, MMP10, MMP1, MMP8, MMP2
50ovarian cancer29.7IL1A, MMP2, MMP9, MMP13

Graphical network of the top 20 diseases related to Arthritis:



Diseases related to arthritis

Symptoms for Arthritis

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Drugs & Therapeutics for Arthritis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arthritis

Drug clinical trials:

Search ClinicalTrials for Arthritis

Search NIH Clinical Center for Arthritis

Search CenterWatch for Arthritis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Arthritis

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Anatomical Context for Arthritis

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Arthritis:

34
Bone, T cells, Monocytes, Endothelial, Skin, B cells, Lung, Testes, Bone marrow, Eye, Heart, Myeloid, Liver, Thyroid, Pituitary, Whole blood, Kidney, Breast, Lymph node, Spleen, Spinal cord, Tonsil, Colon, Nk cells, Salivary gland, Brain, Tongue, Thymus, Small intestine, Cervix, Prostate, Placenta, Retina, Smooth muscle, Skeletal muscle

FMA organs/tissues related to Arthritis:

15
Skin over the joint, Joint

Animal Models for Arthritis or affiliated genes

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Sources:
38MGI
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Publications for Arthritis

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Sources:
53PubMed
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Articles related to Arthritis:

(show top 50)    (show all 11029)
idTitleAuthorsYear
1
JAK/STAT/PKCI' molecular pathways in synovial fluid T lymphocytes reflect the in vivo T helper-17 expansion in psoriatic arthritis. (24385089)
2014
2
Three Cases of Postoperative Septic Arthritis Caused by Mycobacterium conceptionense in Shoulder Joints of Immunocompetent Patients. (24391195)
2014
3
Risk of venous thromboembolism in patients with rheumatoid arthritis: a systematic review and meta-analysis. (24424839)
2014
4
Periarticular bone gain at proximal interphalangeal joints and changes in bone turnover markers in response to tumor necrosis factor inhibitors in rheumatoid and psoriatic arthritis. (23457381)
2013
5
Rituximab and abatacept but not tocilizumab impair antibody response to pneumococcal conjugate vaccine in patients with rheumatoid arthritis. (24286269)
2013
6
Psoriasis and psoriatic arthritis video project: an update from the 2012 GRAPPA annual meeting. (23908546)
2013
7
Impact of temporomandibular joint pain in rheumatoid arthritis. (24363501)
2013
8
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles. (24297382)
2013
9
The when and how of biologic agent withdrawal in rheumatoid arthritis: learning from large randomised controlled trials. (24129131)
2013
10
Presentation of psoriatic arthritis in the literature: a twenty-year bibliometric evaluation. (22451035)
2013
11
Enhanced HMGB1 expression may contribute to Th17 cells activation in rheumatoid arthritis. (22110531)
2012
12
Pyogenic arthritis, pyoderma gangrenosum, and acne syndrome (PAPA syndrome) with E250K mutation in CD2BP1 gene treated with the tumor necrosis factor inhibitor adalimumab. (22513199)
2012
13
Tumor necrosis factor promoter polymorphism TNF*-857 is a risk allele for psoriatic arthritis independent of the PSORS1 locus. (22127698)
2011
14
Interleukin-18: a mediator of inflammation and angiogenesis in rheumatoid arthritis. (21864160)
2011
15
An endocrinologist's view on relative adrenocortical insufficiency in rheumatoid arthritis. (20398019)
2010
16
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
17
Investigation of genetic variants within candidate genes of the TNFRSF1B signalling pathway on the response to anti-TNF agents in a UK cohort of rheumatoid arthritis patients. (19262425)
2009
18
Purpura fulminans in a patient with rheumatoid arthritis. (19997707)
2009
19
Update on the management of pain in arthritis and the use of cyclooxygenase-2 inhibitors. (19889287)
2009
20
Genetic loci contributing to hemophagocytic lymphohistiocytosis do not confer susceptibility to systemic-onset juvenile idiopathic arthritis. (18311812)
2008
21
Overexpression of toll-like receptors 3 and 4 in synovial tissue from patients with early rheumatoid arthritis: toll-like receptor expression in early and longstanding arthritis. (19035519)
2008
22
Analysis of factors influencing prognosis in foals with septic arthritis. (21851707)
2008
23
Large pericardial effusion requiring pericardiocentesis as cardinal sign of macrophage activation syndrome in systemic onset-juvenile idiopathic arthritis. (17160383)
2007
24
What is after cytokine-blocking therapy, a novel therapeutic target-- synovial Epstein-Barr virus for rheumatoid arthritis. (17289546)
2007
25
Interleukin-15 selectively expands CD57+ CD28- CD4+ T cells, which are increased in active rheumatoid arthritis. (17644042)
2007
26
High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis. (17393419)
2007
27
Interleukin-1beta influences the effect of infliximab on temporomandibular joint pain in rheumatoid arthritis. (16766364)
2006
28
New immunoserological tests and pathogenesis for rheumatoid arthritis]. (16190360)
2005
29
TNF inhibitors for inflammatory arthritis in New Zealand. (16258581)
2005
30
Synthesis and activity of substituted 4-(indazol-3-yl)phenols as pathway-selective estrogen receptor ligands useful in the treatment of rheumatoid arthritis. (15588074)
2004
31
Novel approaches to gene expression analysis of active polyarticular juvenile rheumatoid arthritis. (14979934)
2004
32
Streptococcal toxic shock syndrome and sepsis manifesting in a patient with chronic rheumatoid arthritis. (15347489)
2004
33
Twenty eight joint count disease activity score in recent onset rheumatoid arthritis using C reactive protein instead of erythrocyte sedimentation rate. (12810437)
2003
34
Lack of association between juvenile idiopathic arthritis and fas gene polymorphism. (11824955)
2002
35
Expression of interleukin-18 and its monokine-directed function in rheumatoid arthritis. (11285378)
2001
36
Blau syndrome (familial granulomatous arthritis, iritis, and rash) in an african-american family. (19078446)
2000
37
What's new in the diagnosis and treatment of juvenile rheumatoid arthritis. (10912594)
2000
38
Genetic association between rheumatoid arthritis and estrogen receptor microsatellite polymorphism. (10914844)
2000
39
Juvenile rheumatoid arthritis in a Canadian First Nations (aboriginal) population: onset subtypes and HLA associations. (9558186)
1998
40
Heat shock proteins as potential targets in the therapy of inflammatory arthritis. (9559974)
1998
41
Geographic choroiditis and retinal vasculitis in rheumatoid arthritis. (9537875)
1998
42
Cross-reactivity between Borrelia burgdorferi and "arthrogenic" bacteria in sera from patients with reactive arthritis. (8673811)
1996
43
Complement components C1q, C1r/C1s, and C1INH in rheumatoid arthritis. Correlation of in situ hybridization and northern blot results with function and protein concentration in synovium and primary cell cultures. (7718002)
1995
44
Cytokine levels in serum and synovial fluid of patients with juvenile rheumatoid arthritis. (7699643)
1994
45
New directions for biological therapy in rheumatoid arthritis. (8199454)
1994
46
Circulating concentrations and production of cytokines and soluble receptors in rheumatoid arthritis patients: effects of a single dose methotrexate. (7981988)
1994
47
The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis]. (1887430)
1991
48
Studies on the metabolism of D-penicillamine and its interaction with probenecid in cystinuria and rheumatoid arthritis. (6481720)
1984
49
Alkaptonuria, ochronosis, and arthritis in a Cypriot woman. (13938285)
1963
50
Intestinal perforation and widespread arteritis in rheumatoid arthritis during treatment with cortisone. (13629041)
1959

Variations for Arthritis

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Expression for genes affiliated with Arthritis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arthritis

Search GEO for disease gene expression data for Arthritis.

Pathways for genes affiliated with Arthritis

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 55R&D Systems, 54QIAGEN, 61Thomson Reuters, 31KEGG, 13EMD Millipore
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Pathways related to Arthritis according to GeneCards/GeneDecks:

(show all 33)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.3MMP1, MMP9
210.3MMP1, MMP2
310.3MMP9, MMP2
410.2LTA, IL10
510.2MMP1, MMP3, MMP9
6
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
10.2MMP1, MMP3, MMP13
710.2MMP9, MMP13, SERPINH1
810.2MMP9, MMP2, IL6
910.2MMP9, MMP2, IL6
1010.2MMP2, MMP9, MMP13
11
Show member pathways
IL23-mediated signaling events39
Immune response IL 10 signaling pathway61
Angiopoietin receptor Tie2-mediated signaling39
Development PDGF signaling via STATs and NF kB61
Development Angiopoietin Tie2 signaling61
10.2IL6, IL10, MMP2
12
Show member pathways
Apoptosis and survival TNFR1 signaling pathway61
TWEAK Signaling Pathway39
Apoptosis Modulation by HSP7039
HIV-1 Nef- Negative effector of Fas and TNF-alpha39
10.1LTA, IL6, MMP9
1310.1MMP9, IL6, IL1A
14
Show member pathways
IL27-mediated signaling events39
10.1LTA, IL6, IL10
1510.1IL10, IL6, IL1A
1610.1IL1A, IL6, IL10
1710.1IL1A, IL6, IL10
1810.1IL1A, IL6, IL10
19
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
10.1IL6, IL1A, LTA
20
Show member pathways
10.1SERPINH1, MMP13, MMP9, MMP3
2110.1IL6, MMP1, MMP2, MMP9
2210.1IL6, MMP1, MMP2, MMP9
2310.1MMP3, MMP1, IL6, IL1A
2410.1MMP9, MMP3, IL6, LTA
25
Show member pathways
10.0LTA, IL1A, IL6, IL10
2610.0IL10, IL6, IL1A, LTA
27
Show member pathways
9.9LTA, IL1A, IL6, IL10, PTPN22
289.8MMP9, MMP12, MMP2, MMP11, MMP1, IL6
29
Show member pathways
9.3MMP2, MMP12, MMP9, MMP13, MMP3, MMP11
30
Show member pathways
9.2MMP13, MMP9, MMP12, MMP2, MMP3, MMP11
31
Show member pathways
9.2MMP13, MMP15, MMP1, MMP19, MMP8, MMP10
32
Show member pathways
9.0MMP17, MMP3, MMP2, MMP12, MMP9, MMP13
33
Show member pathways
8.9MMP15, MMP1, MMP19, MMP8, MMP10, MMP11

Compounds for genes affiliated with Arthritis

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 30IUPHAR, 25HMDB, 62Tocris Bioscience, 3BitterDB
See all sources

Compounds related to Arthritis according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1ilomastat4610.4MMP9, MMP1, MMP3, MMP2
2pentoxifylline46 1211.4IL10, IL6, IL1A, LTA
3latanoprost46 1211.4MMP9, MMP2, MMP3, MMP1
4clodronate46 52 1212.3MMP1, IL6, IL10, MMP8, MMP13
5cgs-27023a4610.3MMP9, MMP2, MMP1
6alendronate46 52 1212.3MMP8, MMP3, MMP2, MMP13, MMP1
7rantes4610.2IL1A, IL10, MMP1, MMP3, MMP9, MMP13
8etanercept46 52 1212.2MMP3, MMP12, LTA, IL6, IL10, MMP1
9doxycycline46 1211.2MMP13, MMP3, MMP9, MMP2, MMP8, MMP1
10hydroxamate4610.2MMP13, MMP9, MMP12, MMP2, MMP3, MMP1
11infliximab46 52 1212.2IL6, IL10, MMP1, LTA, MMP3
12ivig4610.2LTA, MMP2, IL1A, MMP9, IL6, IL10
13procollagen4610.2MMP3, MMP2, MMP9, SERPINH1, IL1A, MMP1
14(4-aminophenyl)mercuric acetate4610.2MMP13, MMP9, MMP2, MMP8, MMP1, MMP10
15ibuprofen46 30 52 25 1214.2IL10, MMP1, MMP2, IL6, MMP3
16tetracycline46 1211.2IL1A, MMP8, MMP2, MMP9, MMP1, MMP13
17glycosaminoglycan4610.1MMP13, MMP9, MMP3, MMP8, MMP1, IL1A
18aprotinin46 1211.1MMP13, MMP9, IL10, MMP2, MMP1, IL6
19n-isobutyl-n-[4-methoxyphenylsulfonyl]glycyl hydroxamic acid46 1211.1MMP10, MMP3, MMP12
20prednisolone46 30 1212.1MMP1, LTA, IL6, IL10, MMP13, MMP2
21egcg4610.1MMP3, MMP1, IL1A, MMP2, MMP13, MMP9
22pdtc4610.1MMP9, MMP2, MMP1, IL6, IL1A
23curcumin4610.1IL6, MMP13, MMP2, MMP3, MMP1, MMP9
24herbimycin a46 6211.1MMP9, MMP2, MMP13, MMP1, IL1A, LTA
25tgf beta14610.1LTA, IL6, MMP1, MMP3, MMP13, MMP2
26hyaluronic acid46 2511.0IL1A, MMP13, MMP9, MMP2, MMP3, LTA
27prostaglandin4610.0IL1A, MMP1, MMP9, MMP3, MMP13, IL6
28sb 20358046 6211.0IL1A, MMP13, MMP3, IL6, MMP2, MMP9
29matrigel4610.0MMP13, MMP9, MMP12, MMP2, MMP3, MMP10
30genistein46 30 62 3 25 1214.9MMP12, MMP13, MMP9, MMP2, MMP3, MMP8
31cyclosporin a46 30 6211.9IL1A, IL6, IL10, MMP1, MMP8, MMP3
32paraffin469.9MMP2, MMP9, LTA, IL10, MMP1, MMP13
33methotrexate52 46 1211.9IL10, IL6, MMP2, MMP9, MMP3, MMP1
34cycloheximide469.9MMP3, MMP9, MMP2, MMP1, IL10, IL6
3512-o-tetradecanoylphorbol 13-acetate469.9MMP13, MMP9, MMP2, MMP3, LTA, IL1A
36pge2469.8MMP2, MMP3, MMP9, MMP13, MMP8, MMP1
37dexamethasone46 52 30 1212.8MMP9, MMP12, MMP3, MMP1, IL10, IL6
38progesterone46 30 62 25 1213.8IL1A, MMP8, MMP2, MMP3, MMP11, LTA
39lactate469.7IL6, MMP1, MMP8, MMP3, MMP2, MMP9
40pravastatin46 52 30 25 1213.7MMP1, MMP2, MMP3, IL6, IL1A
41retinoic acid46 2510.6MMP13, LTA, MMP9, IL1A, BST1, IL6
42oligonucleotide469.6MMP13, MMP1, MMP8, SERPINH1, MMP10, LTA
43gi 254023x629.5MMP8, MMP19, MMP1, MMP15, MMP3, MMP13
44gm 6001629.5MMP19, MMP1, MMP15, MMP8, MMP10, MMP13
45serine469.5IL1A, MMP2, MMP1, MMP8, MMP10, MMP11
46marimastat46 62 1211.5MMP13, MMP9, MMP12, MMP2, MMP3, MMP17
47batimastat46 62 1211.5MMP15, MMP1, MMP19, MMP9, MMP12, MMP2
48uk 383367629.5MMP13, MMP12, MMP2, MMP3, MMP17, MMP11
49vegf469.3MMP8, MMP10, MMP11, MMP3, MMP2, MMP12
50calcium46 52 25 1212.2MMP3, LTA, BST1, MMP13, MMP9, MMP12

GO Terms for genes affiliated with Arthritis

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Sources:
17Gene Ontology
See all sources

Cellular components related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.1MMP3, MMP2, MMP12, MMP9, MMP11, MMP10
2proteinaceous extracellular matrixGO:0055789.1MMP1, MMP13, MMP9, MMP12, MMP2, MMP3
3extracellular spaceGO:0056159.0MMP2, MMP9, MMP13, SERPINH1, MMP3, MMP10

Biological processes related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1negative regulation of growth of symbiont in hostGO:04413010.2LTA, IL10
2humoral immune responseGO:0069599.8LTA, IL6, BST1
3proteolysisGO:0065089.4MMP13, MMP9, MMP12, MMP2, MMP3, MMP11
4collagen catabolic processGO:0305749.2MMP12, MMP2, MMP3, MMP11, MMP10, MMP8
5extracellular matrix disassemblyGO:0226179.2MMP13, MMP9, MMP12, MMP2, MMP3, MMP11
6extracellular matrix organizationGO:0301989.0MMP12, MMP2, MMP3, MMP11, MMP10, MMP8

Molecular functions related to Arthritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.0LTA, IL1A, IL6, IL10
2metalloendopeptidase activityGO:0042229.0MMP15, MMP13, MMP9, MMP12, MMP2, MMP3
3calcium ion bindingGO:0055098.9MMP13, MMP12, MMP3, MMP17, MMP11, MMP10
4zinc ion bindingGO:0082708.9MMP3, MMP2, MMP12, MMP9, MMP13, MMP17

Products for genes affiliated with Arthritis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arthritis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet