MCID: ART023
MIFTS: 64

Arthropathy malady

Bone diseases category
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Summaries for Arthropathy

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Wikipedia:65 An arthropathy is a disease of a joint. more...

MalaCards based summary: Arthropathy, also known as ankylosis of joint of multiple sites, is related to hemochromatosis and amyloidosis. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The compounds pentosidine and hcc-1 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and t cells, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that is located in joint.

Aliases & Classifications for Arthropathy

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 57SNOMED-CT, 34MeSH, 27ICD9CM, 39NCIt, 25ICD10
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Arthropathy, Aliases & Descriptions:

Name: Arthropathy 8 10 44 62
Ankylosis of Joint of Multiple Sites 8 62
Joint Ankylosis of the Pelvic Region and Thigh 8
Ankylosis of Joint of Pelvic Region and Thigh 8
Joint Ankylosis of the Ankle and/or Foot 8
Ankylosis of Joint of Ankle and/or Foot 8
Joint Ankylosis of the Shoulder Region 8
Joint Ankylosis of the Ankle and Foot 8
Ankylosis of Joint of Shoulder Region 8
Arthropathy Associated with Infection 62
Ankylosis of Ankle and Foot Joint 8
Joint Ankylosis of the Upper Arm 8
Joint Ankylosis of the Lower Leg 8
 
Ankylosis of Joint of Upper Arm 8
Ankylosis of Joint of Lower Leg 8
Joint Ankylosis of the Forearm 8
Ankylosis of Joint of Forearm 8
Ankylosis of Multiple Joints 8
Ankylosis of Lower Leg Joint 8
Ankylosis of Upper Arm Joint 8
Joint Ankylosis of the Hand 8
Ankylosis of Joint of Hand 8
Ankylosis of Forearm Joint 8
Ankylosis of Hand Joint 8
Infectious Arthropathy 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Related Diseases for Arthropathy

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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis30.7HFE, B2M
2amyloidosis30.1B2M, F9
3ankylosing spondylitis30.1TNFSF11, TNFRSF11B
4multiple myeloma30.1TNFRSF11B, TNFSF11, B2M
5psoriatic arthritis30.0TNFSF11, COMP, TNFRSF11B
6myeloma30.0B2M, TNFSF11, TNFRSF11B
7aneurysm30.0MMP2, TNFRSF11B
8gingivitis29.8TNFRSF11B, TNFSF11
9arthritis29.6HFE, COMP, MMP2, TNFSF11, WISP3, B2M
10synovitis29.6TNFRSF11B, COMP, B2M, TNFSF11, PRG4
11osteoarthritis29.5HFE, TNFRSF11B, COMP, PRG4, MMP2, TNFSF11
12rheumatoid arthritis29.5B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
13primary hyperoxaluria29.3TNFSF11, HFE, TNFRSF11B, B2M
14hemophilic arthropathy10.9
15camptodactyly arthropathy coxa vara pericarditis syndrome10.6
16neurogenic arthropathy10.5
17progressive pseudorheumatoid arthropathy of childhood10.5
18torg winchester syndrome10.5
19lupus erythematosus10.4
20pericarditis10.4
21systemic lupus erythematosus10.4
22syringomyelia10.4
23reactive arthritis10.4
24periapical granuloma10.4TNFSF11
25behcet's syndrome arthropathy10.4
26pseudogout10.4
27gout10.4
28distal arthrogryposis10.3
29transient arthropathy10.3
30enthesopathy10.3
31ochronosis10.3
32neuropathy10.3
33cervicitis10.3
34psoriasis10.3
35hemophilia10.3
36diabetes mellitus10.2
37hepatitis10.2
38osteoporosis10.2
39acromegaly10.2
40periodontal disease10.2MMP2, TNFSF11
41juvenile rheumatoid arthritis10.2
42alkaptonuria10.2
43vasculitis10.2
44digital arthropathy-brachydactyly, familial10.2
45inflammatory bowel disease10.2
46atlantoaxial subluxation10.2
47leukemia10.1
48hepatitis c10.1
49dermatomyositis10.1
50chondrocalcinosis 210.1

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to arthropathy

Symptoms for Arthropathy

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Drugs & Therapeutics for Arthropathy

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Drug clinical trials:

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Search NIH Clinical Center for Arthropathy

Genetic Tests for Arthropathy

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Anatomical Context for Arthropathy

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MalaCards organs/tissues related to Arthropathy:

32
Bone, T cells, Heart, Spinal cord, Liver, Lung, Skin, Bone marrow, Neutrophil, Eye, Ovary, Uterus, Testes, Cervix, Monocytes, Pituitary

FMA organs/tissues related to Arthropathy:

14
Joint

Animal Models for Arthropathy or affiliated genes

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MGI Mouse Phenotypes related to Arthropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFSF11, TNFRSF11B, PRG4, COMP, HFE
2MP:00053907.9TNFSF11, TNFRSF11B, MMP2, PRG4, COMP
3MP:00053767.8TRPV4, HFE, MMP2, TNFSF11, B2M, F9
4MP:00053857.7F9, B2M, TNFRSF11B, MMP2, PRG4, TRPV4
5MP:00053977.3F9, B2M, TNFSF11, TNFRSF11B, MMP2, HFE
6MP:00053787.1B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
7MP:00107687.1F9, B2M, TNFSF11, TNFRSF11B, MMP2, PRG4
8MP:00053877.0HFE, COMP, MMP2, TNFRSF11B, TNFSF11, B2M

Publications for Arthropathy

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Articles related to Arthropathy:

(show top 50)    (show all 797)
idTitleAuthorsYear
1
Charcot arthropathy of the elbow joint as a presenting feature of Chiari malformation with syringomyelia. (25076017)
2014
2
Progression of haemophilic arthropathy in children: a Lithuanian--Danish comparative study. (23167920)
2013
3
Primary knee arthrodesis for severe crystalline arthropathy. (24278911)
2013
4
Risk factors for dislocation arthropathy after Latarjet procedure: a long-term study. (23508865)
2013
5
Acute charcot arthropathy of the wrist in a diabetic patient. (22961091)
2013
6
Jaccoud's arthropathy. (23290493)
2013
7
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. (23623735)
2013
8
Rapidly destructive arthropathy of the hip joint in patients with rheumatoid arthritis. (22691675)
2012
9
Occult erosions in Jaccoud arthropathy. (22832301)
2012
10
Atypical case of hypertrophic osteo-arthropathy. (23029954)
2012
11
Reverse total shoulder arthroplasty for cuff tear arthropathy: the clinical effect of deltoid lengthening and center of rotation medialization. (22056324)
2012
12
Visualization of amyloid arthropathy in light-chain systemic amyloidosis on F-18 FDG PET/CT scan. (21157212)
2011
13
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
14
Usefulness of wireless capsule endoscopy for detecting inflammatory bowel disease in children presenting with arthropathy. (21643650)
2011
15
Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score. (21070482)
2011
16
Bypassing agent prophylaxis for preventing arthropathy in patients with inhibitors. (19702885)
2010
17
Midtarsal arthrodesis in the treatment of Charcot midfoot arthropathy. (19122082)
2009
18
Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies. (19738232)
2009
19
Use of platelet-rich concentrate and bone marrow aspirate in high-risk patients with Charcot arthropathy of the foot. (19254506)
2009
20
Acute gouty arthropathy mimicking infection after total knee arthroplasty. (19627909)
2009
21
Refinement of a sonographic protocol for assessment of haemophilic arthropathy. (19493019)
2009
22
The outcome of cementless total hip arthroplasty in haemophilic hip arthropathy. (19444974)
2009
23
Complications in the management of Charcot spinal arthropathy. (19769521)
2009
24
Haemophilic arthropathy from A to Z. Introduction. (18494685)
2008
25
Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment. (19134026)
2008
26
Magnetic resonance imaging in early stage charcot arthropathy: correlation of imaging findings and clinical symptoms. (18948232)
2008
27
Charcot arthropathy risk elevation in the obese diabetic population. (18954849)
2008
28
Orthopaedic management of haemophilia arthropathy of the ankle. (18510538)
2008
29
The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy. (18612836)
2008
30
Sonography for assessment of haemophilic arthropathy in children: a systematic protocol. (17498079)
2007
31
Rotator cuff tear arthropathy. (17548883)
2007
32
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. (17563703)
2007
33
Gouty arthropathy of the cervical spine in a young adult. (17475601)
2007
34
Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women. (16551465)
2006
35
Calcium pyrophosphate dihydrate-crystal induced arthropathy]. (14991274)
2004
36
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
37
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. (10782809)
2000
38
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
39
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
40
The arthropathy of the Muckle-Wells syndrome. (8000753)
1994
41
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
42
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
43
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
44
Radiographic and therapeutic aspects of neurogenic arthropathy. (1297567)
1992
45
Resorptive arthropathy and rib erosions in mixed connective tissue disease. (2359089)
1990
46
Arthropathy in von Willebrand's disease. (2787227)
1989
47
Idiopathic neurogenic arthropathy. (4044822)
1985
48
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
49
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. (6681882)
1983
50
Hemophilic arthropathy. (13775889)
1960

Variations for Arthropathy

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Expression for genes affiliated with Arthropathy

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Expression patterns in normal tissues for genes affiliated with Arthropathy

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Pathways for genes affiliated with Arthropathy

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Compounds for genes affiliated with Arthropathy

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Compounds related to Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pentosidine449.7B2M, COMP
2hcc-1449.5TNFSF11, TNFRSF11B
3denosumab44 1110.5TNFRSF11B, TNFSF11
4teriparatide44 1110.4TNFSF11, TNFRSF11B
5polyethylene449.4TNFSF11, TNFRSF11B
6hyaluronic acid44 2410.3B2M, COMP, PRG4, MMP2
7ibandronate44 1110.3TNFRSF11B, TNFSF11
8latex449.3PRG4, TNFSF11, F9
9zoledronic acid449.2TNFRSF11B, TNFSF11, MMP2
10alendronate44 50 1111.2TNFSF11, TNFRSF11B, MMP2
11ns 39844 6110.2MMP2, TNFRSF11B, TNFSF11
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide449.2MMP2, TNFRSF11B, TNFSF11
13hydroxyapatite449.2TNFRSF11B, PRG4, TNFSF11
14alginate449.2COMP, F9, MMP2, PRG4
15pamidronate44 50 1111.2TNFSF11, B2M, TNFRSF11B
16celecoxib44 61 28 50 24 1114.2MMP2, TNFRSF11B, TNFSF11
17pmma449.1TNFSF11, TNFRSF11B, B2M
1825-hydroxyvitamin d449.1TNFSF11, TNFRSF11B, B2M
19phosphorus449.1TNFSF11, B2M, TNFRSF11B
20azathioprine44 2 50 1112.1MMP2, TNFRSF11B, TNFSF11
21deoxypyridinoline449.0COMP, TNFRSF11B, TNFSF11
22etanercept44 50 1111.0COMP, TNFRSF11B, TNFSF11
23infliximab44 50 1111.0COMP, TNFSF11, TNFRSF11B
24p003448.9TNFRSF11B, HFE, COMP
25tgf beta1448.9TNFRSF11B, MMP2, COMP
26hydrocortisone44 2 61 1111.9TNFRSF11B, MMP2, F9
27vitamin k2448.8TNFRSF11B, TNFSF11
28ascorbic acid44 249.7TNFSF11, HFE, MMP2, TNFRSF11B
29procollagen448.7MMP2, TNFRSF11B, TNFSF11, COMP
30heparan sulfate44 249.7B2M, TNFRSF11B, TNFSF11
31genistein44 28 61 2 24 1113.7TNFSF11, MMP2, TNFRSF11B, B2M
32methotrexate50 44 1110.7TNFSF11, TNFRSF11B, MMP2, COMP
33pge2448.7TNFSF11, B2M, TNFRSF11B, MMP2
34alanine448.6B2M, TRPV4, MMP2, F9, HFE
35prednisolone44 28 1110.6MMP2, COMP, F9, TNFRSF11B
36vitamin d448.6TNFSF11, TNFRSF11B, COMP, B2M
37urea44 24 1110.5TNFRSF11B, B2M, F9, TNFSF11
38sodium44 249.5TRPV4, TNFSF11, B2M, TNFRSF11B
39vegf448.4MMP2, TNFRSF11B, WISP3, B2M, TNFSF11
40cyclosporin a44 28 6110.4TNFRSF11B, TNFSF11, B2M, F9
41cycloheximide448.4B2M, TNFSF11, TNFRSF11B, MMP2
42glucose447.9B2M, F9, TNFRSF11B, HFE, COMP
43aspartate447.8HFE, COMP, F9, B2M, MMP2, TNFRSF11B
44testosterone44 61 24 1110.8B2M, TNFSF11, F9, TNFRSF11B, MMP2, HFE
45estrogen447.8B2M, F9, TNFSF11, TNFRSF11B, MMP2, HFE
46creatinine447.7MMP2, F9, COMP, TNFRSF11B, TNFSF11, B2M
47tyrosine447.7TNFRSF11B, TRPV4, MMP2, TNFSF11, F9, HFE
48lipid447.4HFE, F9, TNFSF11, TNFRSF11B, COMP
49calcium44 50 24 1110.3COMP, MMP2, TNFRSF11B, TNFSF11, F9, B2M
50cysteine446.9HFE, F9, WISP3, TNFSF11, MMP2, B2M

GO Terms for genes affiliated with Arthropathy

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Cellular components related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.3HFE, B2M
2proteinaceous extracellular matrixGO:0055788.8COMP, MMP2, TNFRSF11B
3extracellular spaceGO:0056157.2COMP, B2M, WISP3, TNFSF11, TNFRSF11B, MMP2
4extracellular regionGO:0055767.2F9, B2M, TNFSF11, TNFRSF11B, MMP2, COMP

Biological processes related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell mediated cytotoxicityGO:0019169.5HFE, B2M
2immune responseGO:0069559.2HFE, PRG4, TNFSF11
3extracellular matrix organizationGO:0301988.5COMP, MMP2, TNFRSF11B

Products for genes affiliated with Arthropathy

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Sources for Arthropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet