MCID: ART023
MIFTS: 54

Arthropathy malady

Bone diseases category

Summaries for Arthropathy

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Wikipedia:63 An arthropathy is a disease of a joint. more...

MalaCards based summary: Arthropathy, also known as ankylosis of joint of multiple sites, is related to hemochromatosis and osteoporosis. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The compounds pentosidine and hcc-1 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and t cells, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:9 A bone inflammation disease that is located in joint.

Aliases & Classifications for Arthropathy

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Sources:
9Disease Ontology, 11DISEASES, 43Novoseek, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 25ICD10
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Arthropathy, Aliases & Descriptions:

Name: Arthropathy 9 11 43 60
Ankylosis of Joint of Multiple Sites 9 60
Joint Ankylosis of the Pelvic Region and Thigh 9
Ankylosis of Joint of Pelvic Region and Thigh 9
Joint Ankylosis of the Ankle and/or Foot 9
Ankylosis of Joint of Ankle and/or Foot 9
Joint Ankylosis of the Shoulder Region 9
Joint Ankylosis of the Ankle and Foot 9
Ankylosis of Joint of Shoulder Region 9
Arthropathy Associated with Infection 60
Ankylosis of Ankle and Foot Joint 9
Joint Ankylosis of the Lower Leg 9
Joint Ankylosis of the Upper Arm 9
 
Ankylosis of Joint of Upper Arm 9
Ankylosis of Joint of Lower Leg 9
Joint Ankylosis of the Forearm 9
Ankylosis of Joint of Forearm 9
Ankylosis of Multiple Joints 9
Ankylosis of Lower Leg Joint 9
Ankylosis of Upper Arm Joint 9
Joint Ankylosis of the Hand 9
Ankylosis of Joint of Hand 9
Ankylosis of Forearm Joint 9
Ankylosis of Hand Joint 9
Infectious Arthropathy 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Related Diseases for Arthropathy

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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 244)
idRelated DiseaseScoreTop Affiliating Genes
1hemochromatosis30.7HFE, B2M
2osteoporosis30.4TNFRSF11B, TNFSF11
3amyloidosis30.1B2M, F9
4multiple myeloma30.1B2M, TNFSF11, TNFRSF11B
5myeloma30.0B2M, TNFSF11, TNFRSF11B
6psoriatic arthritis30.0TNFSF11, TNFRSF11B, COMP
7aneurysm29.9MMP2, TNFRSF11B
8gingivitis29.8TNFRSF11B, TNFSF11
9arthritis29.6B2M, WISP3, TNFSF11, TNFRSF11B, MMP2, COMP
10synovitis29.6B2M, TNFSF11, TNFRSF11B, PRG4, COMP
11osteoarthritis29.6TNFSF11, TNFRSF11B, MMP2, PRG4, COMP, HFE
12rheumatoid arthritis29.5B2M, TNFSF11, TNFRSF11B, MMP2, PRG4, COMP
13primary hyperoxaluria29.3B2M, TNFSF11, TNFRSF11B, HFE
14hemophilic arthropathy10.9
15camptodactyly-arthropathy-coxa vara-pericarditis syndrome10.6
16arthropathy, progressive pseudorheumatoid, of childhood10.5
17neurogenic arthropathy10.5
18multicentric osteolysis, nodulosis, and arthropathy10.5
19syringomyelia10.4
20lupus erythematosus10.4
21pericarditis10.4
22systemic lupus erythematosus10.4
23periapical granuloma10.4TNFSF11
24behcet's syndrome arthropathy10.4
25reactive arthritis10.4
26transient arthropathy10.4
27gout10.4
28enthesopathy10.3
29ochronosis10.3
30digital arthropathy-brachydactyly, familial10.3
31neuropathy10.3
32spondyloepiphyseal dysplasia tarda10.3
33cervicitis10.3
34psoriasis10.3
35hemophilia10.3
36alkaptonuria10.2
37hepatitis10.2
38acromegaly10.2
39inflammatory bowel disease10.2
40periodontal disease10.2MMP2, TNFSF11
41distal arthrogryposis10.2
42chondrocalcinosis 210.2
43chondrocalcinosis10.2
44juvenile rheumatoid arthritis10.2
45vasculitis10.2
46atlantoaxial subluxation10.2
47leukemia10.1
48hepatitis c10.1
49dermatomyositis10.1
50abdominal aortic aneurysm10.1MMP2, TNFRSF11B

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to arthropathy

Symptoms for Arthropathy

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Drugs & Therapeutics for Arthropathy

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Drug clinical trials:

Search ClinicalTrials for Arthropathy

Search NIH Clinical Center for Arthropathy

Genetic Tests for Arthropathy

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Anatomical Context for Arthropathy

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MalaCards organs/tissues related to Arthropathy:

31
Bone, T cells, Spinal cord, Heart, Liver, Lung, Skin, Bone marrow, Neutrophil, Eye, Ovary, Uterus, Testes, Cervix, Monocytes, Pituitary

FMA organs/tissues related to Arthropathy:

14
Joint

Animal Models for Arthropathy or affiliated genes

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MGI Mouse Phenotypes related to Arthropathy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFSF11, TNFRSF11B, PRG4, COMP, HFE
2MP:00053907.9TNFSF11, TNFRSF11B, MMP2, PRG4, COMP
3MP:00053767.8TRPV4, HFE, MMP2, TNFSF11, B2M, F9
4MP:00053857.7F9, B2M, TNFRSF11B, MMP2, PRG4, TRPV4
5MP:00053977.3F9, B2M, TNFSF11, TNFRSF11B, MMP2, HFE
6MP:00053787.1B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
7MP:00107687.1F9, B2M, TNFSF11, TNFRSF11B, MMP2, PRG4
8MP:00053877.0HFE, COMP, MMP2, TNFRSF11B, TNFSF11, B2M

Publications for Arthropathy

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Articles related to Arthropathy:

(show top 50)    (show all 817)
idTitleAuthorsYear
1
Estimation of tensile properties of the Achilles tendon in haemophilic arthropathy of the ankle: case study. (25622924)
2015
2
Charcot arthropathy of the elbow joint as a presenting feature of Chiari malformation with syringomyelia. (25076017)
2014
3
Progression of haemophilic arthropathy in children: a Lithuanian--Danish comparative study. (23167920)
2013
4
Primary knee arthrodesis for severe crystalline arthropathy. (24278911)
2013
5
Risk factors for dislocation arthropathy after Latarjet procedure: a long-term study. (23508865)
2013
6
Acute charcot arthropathy of the wrist in a diabetic patient. (22961091)
2013
7
Jaccoud's arthropathy. (23290493)
2013
8
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. (23623735)
2013
9
Rapidly destructive arthropathy of the hip joint in patients with rheumatoid arthritis. (22691675)
2012
10
Occult erosions in Jaccoud arthropathy. (22832301)
2012
11
Atypical case of hypertrophic osteo-arthropathy. (23029954)
2012
12
Reverse total shoulder arthroplasty for cuff tear arthropathy: the clinical effect of deltoid lengthening and center of rotation medialization. (22056324)
2012
13
Visualization of amyloid arthropathy in light-chain systemic amyloidosis on F-18 FDG PET/CT scan. (21157212)
2011
14
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
15
Usefulness of wireless capsule endoscopy for detecting inflammatory bowel disease in children presenting with arthropathy. (21643650)
2011
16
Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score. (21070482)
2011
17
Bypassing agent prophylaxis for preventing arthropathy in patients with inhibitors. (19702885)
2010
18
Midtarsal arthrodesis in the treatment of Charcot midfoot arthropathy. (19122082)
2009
19
Destructive arthropathy associated with dermatomyositis sine myositis positive for anti-Jo-1 and anti-cyclic citrullinated peptide antibodies. (19738232)
2009
20
Use of platelet-rich concentrate and bone marrow aspirate in high-risk patients with Charcot arthropathy of the foot. (19254506)
2009
21
Acute gouty arthropathy mimicking infection after total knee arthroplasty. (19627909)
2009
22
Refinement of a sonographic protocol for assessment of haemophilic arthropathy. (19493019)
2009
23
The outcome of cementless total hip arthroplasty in haemophilic hip arthropathy. (19444974)
2009
24
Complications in the management of Charcot spinal arthropathy. (19769521)
2009
25
Haemophilic arthropathy from A to Z. Introduction. (18494685)
2008
26
Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment. (19134026)
2008
27
Magnetic resonance imaging in early stage charcot arthropathy: correlation of imaging findings and clinical symptoms. (18948232)
2008
28
Charcot arthropathy risk elevation in the obese diabetic population. (18954849)
2008
29
Orthopaedic management of haemophilia arthropathy of the ankle. (18510538)
2008
30
The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy. (18612836)
2008
31
Sonography for assessment of haemophilic arthropathy in children: a systematic protocol. (17498079)
2007
32
Rotator cuff tear arthropathy. (17548883)
2007
33
Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. (17563703)
2007
34
Gouty arthropathy of the cervical spine in a young adult. (17475601)
2007
35
Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women. (16551465)
2006
36
Calcium pyrophosphate dihydrate-crystal induced arthropathy]. (14991274)
2004
37
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
38
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. (10782809)
2000
39
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
40
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
41
The arthropathy of the Muckle-Wells syndrome. (8000753)
1994
42
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
43
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
44
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
45
Resorptive arthropathy and rib erosions in mixed connective tissue disease. (2359089)
1990
46
Arthropathy in von Willebrand's disease. (2787227)
1989
47
Idiopathic neurogenic arthropathy. (4044822)
1985
48
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
49
Hemophilic arthropathy. (6048906)
1967
50
Hemophilic arthropathy. (13775889)
1960

Variations for Arthropathy

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Expression for genes affiliated with Arthropathy

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Search GEO for disease gene expression data for Arthropathy.

Pathways for genes affiliated with Arthropathy

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Compounds for genes affiliated with Arthropathy

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Compounds related to Arthropathy according to GeneCards Suite gene sharing:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pentosidine439.7B2M, COMP
2hcc-1439.5TNFRSF11B, TNFSF11
3denosumab43 1210.5TNFSF11, TNFRSF11B
4teriparatide43 1210.4TNFSF11, TNFRSF11B
5polyethylene439.4TNFRSF11B, TNFSF11
6hyaluronic acid43 2410.3B2M, MMP2, PRG4, COMP
7ibandronate43 1210.3TNFRSF11B, TNFSF11
8latex439.3F9, TNFSF11, PRG4
9zoledronic acid439.2TNFSF11, TNFRSF11B, MMP2
10alendronate43 49 1211.2MMP2, TNFRSF11B, TNFSF11
11ns 39843 5910.2TNFSF11, TNFRSF11B, MMP2
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide439.2TNFSF11, TNFRSF11B, MMP2
13hydroxyapatite439.2TNFSF11, TNFRSF11B, PRG4
14alginate439.2F9, MMP2, PRG4, COMP
15pamidronate43 49 1211.2TNFRSF11B, TNFSF11, B2M
16celecoxib43 59 28 49 24 1214.2MMP2, TNFRSF11B, TNFSF11
17pmma439.1TNFRSF11B, TNFSF11, B2M
1825-hydroxyvitamin d439.1B2M, TNFSF11, TNFRSF11B
19phosphorus439.1B2M, TNFSF11, TNFRSF11B
20azathioprine43 2 49 1212.1MMP2, TNFRSF11B, TNFSF11
21deoxypyridinoline439.0TNFSF11, TNFRSF11B, COMP
22etanercept43 49 1211.0TNFSF11, TNFRSF11B, COMP
23infliximab43 49 1211.0COMP, TNFRSF11B, TNFSF11
24p003438.9TNFRSF11B, COMP, HFE
25tgf beta1438.9COMP, MMP2, TNFRSF11B
26hydrocortisone43 2 59 1211.9MMP2, TNFRSF11B, F9
27vitamin k2438.8TNFRSF11B, TNFSF11
28ascorbic acid43 249.7TNFSF11, TNFRSF11B, MMP2, HFE
29procollagen438.7TNFSF11, TNFRSF11B, MMP2, COMP
30heparan sulfate43 249.7TNFRSF11B, TNFSF11, B2M
31genistein43 28 59 2 24 1213.7MMP2, TNFRSF11B, TNFSF11, B2M
32methotrexate49 43 1210.7COMP, MMP2, TNFRSF11B, TNFSF11
33pge2438.7B2M, TNFSF11, TNFRSF11B, MMP2
34alanine438.6F9, B2M, MMP2, HFE, TRPV4
35prednisolone43 28 1210.6F9, TNFRSF11B, MMP2, COMP
36vitamin d438.6COMP, TNFRSF11B, TNFSF11, B2M
37urea43 24 1210.5TNFRSF11B, TNFSF11, B2M, F9
38sodium43 249.5B2M, TNFSF11, TNFRSF11B, TRPV4
39vegf438.4B2M, WISP3, TNFSF11, TNFRSF11B, MMP2
40cyclosporin a43 28 5910.4F9, B2M, TNFSF11, TNFRSF11B
41cycloheximide438.4B2M, TNFSF11, TNFRSF11B, MMP2
42glucose437.9F9, B2M, TNFRSF11B, COMP, HFE
43aspartate437.8F9, B2M, TNFRSF11B, MMP2, COMP, HFE
44testosterone43 59 24 1210.8F9, B2M, TNFSF11, TNFRSF11B, MMP2, HFE
45estrogen437.8F9, B2M, TNFSF11, TNFRSF11B, MMP2, HFE
46creatinine437.7F9, B2M, TNFSF11, TNFRSF11B, MMP2, COMP
47tyrosine437.7F9, TNFSF11, TNFRSF11B, MMP2, HFE, TRPV4
48lipid437.4F9, TNFSF11, TNFRSF11B, COMP, HFE
49calcium43 49 24 1210.3F9, B2M, TNFSF11, TNFRSF11B, MMP2, COMP
50cysteine436.9HFE, F9, B2M, WISP3, TNFSF11, TNFRSF11B

GO Terms for genes affiliated with Arthropathy

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Cellular components related to Arthropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:00426129.3HFE, B2M
2proteinaceous extracellular matrixGO:00055788.8COMP, MMP2, TNFRSF11B
3extracellular spaceGO:00056157.2COMP, B2M, WISP3, TNFSF11, TNFRSF11B, MMP2
4extracellular regionGO:00055767.2F9, B2M, TNFSF11, TNFRSF11B, MMP2, COMP

Biological processes related to Arthropathy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell mediated cytotoxicityGO:00019169.5HFE, B2M
2immune responseGO:00069559.2HFE, PRG4, TNFSF11
3extracellular matrix organizationGO:00301988.5COMP, MMP2, TNFRSF11B

Products for genes affiliated with Arthropathy

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Sources for Arthropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet