MCID: ART023
MIFTS: 65

Arthropathy malady

Summaries for Arthropathy

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Wikipedia:64 An arthropathy is a disease of a joint. more...

MalaCards: Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to arthritis and systemic lupus erythematosus. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are TNF Signaling and Collagen biosynthesis and modifying enzymes. The compounds cysteine and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include joint, skin and ovary, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:8 A bone inflammation disease that is located in joint.

Aliases & Classifications for Arthropathy

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt, 25ICD10
See all sources

Classifications:



Aliases & Descriptions:

arthropathy 8 10 45 61
joint ankylosis of the pelvic region and thigh 8
ankylosis of joint of pelvic region and thigh 8
joint ankylosis of the ankle and/or foot 8
ankylosis of joint of ankle and/or foot 8
joint ankylosis of the shoulder region 8
joint ankylosis of the ankle and foot 8
ankylosis of joint of shoulder region 8
arthropathy associated with infection 61
ankylosis of joint of multiple sites 8
ankylosis of ankle and foot joint 8
joint ankylosis of the lower leg 8
joint ankylosis of the upper arm 8
ankylosis of joint of upper arm 8
ankylosis of joint of lower leg 8
joint ankylosis of the forearm 8
ankylosis of joint of forearm 8
ankylosis of lower leg joint 8
ankylosis of multiple joints 8
ankylosis of upper arm joint 8
joint ankylosis of the hand 8
ankylosis of joint of hand 8
ankylosis of forearm joint 8
ankylosis of hand joint 8
infectious arthropathy 8


Related Diseases for Arthropathy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Arthropathy family:

transient arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 274)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.8VTN, MMP2, MMP13, CXCL10, CD69, HFE
2systemic lupus erythematosus30.6CXCL10, CD69, F8, COMP, VTN
3osteoarthritis30.4MMP2, MMP13, HAS1, TNFRSF11B, TNFSF11, TNFRSF11A
4osteoporosis30.3TNFSF11, TNFRSF11B, MMP13, TNFRSF11A
5synovitis30.2MMP13, CD69, PRG4, B2M, TNFRSF11B, TNFSF11
6psoriatic arthritis30.2TNFRSF11B, COMP, TNFSF11
7hepatitis c30.2CXCL10, CD69, HFE
8hepatitis a30.2F8
9amyloidosis30.1B2M, F9
10sickle cell disease29.9F9
11thalassemia29.9HFE
12hemarthrosis29.9F9, F8
13cystic fibrosis29.7F8, F9, TNFRSF11B
14nephritis29.7VTN, B2M
15primary hyperoxaluria29.7MMP2, TNFRSF11B, F8
16factor xi deficiency29.7F8, F9
17factor xii deficiency29.7F9
18hemophilic arthropathy10.9
19camptodactyly arthropathy coxa vara pericarditis syndrome10.6
20neurogenic arthropathy10.5
21torg winchester syndrome10.4
22progressive pseudorheumatoid arthropathy of childhood10.4
23gout10.4
24pseudogout10.4
25syringomyelia10.4
26behcet's syndrome arthropathy10.3
27transient arthropathy10.3
28hemophilia10.3
29hemochromatosis10.3
30ochronosis10.3
31jaccoud's syndrome10.2
32acromegaly10.2
33digital arthropathy-brachydactyly, familial10.2
34distal arthrogryposis10.2
35alkaptonuria10.2
36juvenile rheumatoid arthritis10.2
37reactive arthritis10.2
38n syndrome10.2
39atlantoaxial subluxation10.2
40hemophilia b10.1
41vasculitis10.1
42ankylosing spondylitis10.0
43ankylosis10.0
44tabes dorsalis10.0
45hidradenitis suppurativa10.0
46polyarteritis nodosa10.0
47hepatitis d10.0
48hypermobility syndrome10.0
49spondylitis10.0
50t-cell leukemia10.0

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to arthropathy

Clinical Features for Arthropathy

Drugs & Therapeutics for Arthropathy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Arthropathy

Drug clinical trials:

Search ClinicalTrials for Arthropathy

Search NIH Clinical Center for Arthropathy

Search CenterWatch for Arthropathy

Genetic Tests for Arthropathy

Anatomical Context for Arthropathy

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Arthropathy:

33
Skin, Ovary, Liver, Spinal cord, Lung, Uterus, Bone marrow, Heart, Skeletal muscle, Cervix, Monocytes, T cells, B cells, Pituitary

FMA organs/tissues related to Arthropathy:

14
Joint

Animal Models for Arthropathy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Arthropathy

Sources:
51PubMed
See all sources

Articles related to Arthropathy:

(show top 50)    (show all 742)
idTitleAuthorsYear
1
Ferritin in dialysis-related arthropathy: could it be a possible biochemical indicator of articular chronic pain? (24407897)
2013
2
Treatment of severe cuff tear arthropathy with the humeral head resurfacing arthroplasty: two-year minimum follow-up. (22743073)
2013
3
Evaluation of cartilage degeneration in a rat model of rotator cuff tear arthropathy. (23664745)
2013
4
Impact of ankle osteoarthritis on the energetics and mechanics of gait: the case of hemophilic arthropathy. (22381586)
2012
5
Salvage arthrodesis for charcot arthropathy. (22243574)
2012
6
Nonsteroidal antiinflammatory drugs (NSAID) versus NSAID with hydroxychloroquine in treatment of chemotherapy-related arthropathy: open-label multicenter pilot study. (22942309)
2012
7
Pituitary function: arthropathy in acromegaly. (22710365)
2012
8
Comment on: arthropathy with infiltrate IgG4-positive plasma cells in synovium. (22826306)
2012
9
Outcome of total knee arthroplasty combined patelloplasty for end-stage type A hemophilic arthropathy. (21342764)
2012
10
Adjacent level degeneration and facet arthropathy after disc prosthesis surgery or rehabilitation in patients with chronic low back pain and degenerative disc: second report of a randomized study. (22706091)
2012
11
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
12
Prosthetic valve, fever and arthropathy--Still a difficult diagnosis. (22147921)
2011
13
Precision of foot alignment measures in Charcot arthropathy. (22097162)
2011
14
What do standard radiography and clinical examination tell about the shoulder with cuff tear arthropathy? (21208449)
2011
15
High incidence of ankle arthropathy in mild and moderate haemophilia A. (21057696)
2011
16
Validation of a radiographic scoring system for haemochromatosis arthropathy. (20679473)
2010
17
Magnetic resonance imaging of Jaccoud's arthropathy in systemic lupus erythematosus. (20356775)
2010
18
Hemophilic arthropathy. (21623422)
2010
19
Hepatitis C-related arthropathy: Diagnostic and treatment considerations. (21625299)
2010
20
Arthropathy in acromegaly. (21092848)
2010
21
Blood-induced joint disease: the pathophysiology of hemophilic arthropathy. (20586922)
2010
22
Midtarsal arthrodesis in the treatment of Charcot midfoot arthropathy. (19122082)
2009
23
Refinement of a sonographic protocol for assessment of haemophilic arthropathy. (19493019)
2009
24
Use of bioabsorbable knotless suture anchors and associated accelerated shoulder arthropathy: report of 3 cases. (19329785)
2009
25
Clonality of Enterococcus faecalis associated with amyloid arthropathy in chickens evaluated by multilocus sequence typing (MLST). (18819760)
2009
26
Devastating ochronotic arthropathy with successful bilateral hip and knee arthroplasties. (19300282)
2009
27
Quinolone-induced arthropathy: an update focusing on new mechanistic and clinical data. (18835137)
2009
28
Midterm results of cementless total hip replacement in rapidly destructive arthropathy and a review of the literature. (20041382)
2009
29
Orthopaedic management of haemophilia arthropathy of the ankle. (18510538)
2008
30
Prevention of haemophilic arthropathy during childhood. May common orthopaedic management be extrapolated from patients without inhibitors to patients with inhibitors? (19134036)
2008
31
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. (18234151)
2008
32
Hypocomplementemic urticarial vasculitis with Jaccoud's arthropathy and valvular heart disease: case report and review of the literature. (18755866)
2008
33
Atraumatic scapular fractures in the setting of chronic rotator cuff tear arthropathy: a report of two cases. (17931910)
2008
34
CT-guided percutaneous steroid injection for management of inflammatory arthropathy of the temporomandibular joint in children. (17179362)
2007
35
Total knee replacement in haemophilic arthropathy. (17322432)
2007
36
Cytokine-induced osteoclastic bone resorption in charcot arthropathy: an immunohistochemical study. (17054880)
2006
37
Synovial pathology in camptodactyly-arthropathy-coxa vara-pericarditis syndrome. (15702367)
2005
38
Total knee arthroplasty in hemophilic arthropathy. (14716652)
2004
39
Radiological evaluation of hemophilic arthropathy. (12640564)
2003
40
Hemophilic arthropathy of the elbow. (8543615)
1995
41
Serum alpha-1-antitrypsin in hemodialysis patients with dialysis arthropathy. (8314633)
1993
42
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
43
Radiographic and therapeutic aspects of neurogenic arthropathy. (1297567)
1992
44
Treatment of psoriatic arthropathy. (1626281)
1992
45
Surgical management of advanced hemophilic arthropathy. (2408056)
1990
46
Surgical management of hemophilic arthropathy. (2495331)
1989
47
Atlantoaxial subluxation and spinal cord compression in psoriatic arthropathy. (3355253)
1988
48
Human parvovirus B19 arthropathy in two adults after contact with childhood erythema infectiosum. (2821807)
1987
49
Synoviorthesis with colloidal 32P chromic phosphate for hemophilic arthropathy: clinical follow-up. (4062528)
1985
50
Papular mucinosis, destructive arthropathy, median neuropathy, and sicca complex. (6236018)
1983

Genetic Variations for Arthropathy

Expression for genes affiliated with Arthropathy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Pathways for genes affiliated with Arthropathy

Sources:
56SinoBiological, 53R&D Systems, 54Reactome, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database
See all sources

Pathways related to Arthropathy according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5B2M, TNFRSF11B, TNFSF11, TNFRSF11A
2
Hide members
10.5VTN, MMP2, MMP13, F8, F9, COMP
3
Hide members
10.5VTN, MMP2, MMP13, CXCL10, PRG4
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5TNFRSF11A, TNFSF11, TNFRSF11B
5
Hide members
10.5TNFRSF11B, TNFSF11, TNFRSF11A
610.5TNFRSF11A, TNFSF11, TNFRSF11B
710.5TNFRSF11B, TNFSF11
8
Hide members
10.5MMP2, MMP13
9
Hide members
10.5HAS2, HAS1
1010.5HAS2, HAS1
11
Cell adhesion ECM remodeling
Hide members
10.5MMP13, MMP2, VTN

Compounds for genes affiliated with Arthropathy

Sources:
45Novoseek, 24HMDB, 50PharmGKB, 29IUPHAR, 11DrugBank, 2BitterDB, 60Tocris Bioscience
See all sources

Compounds related to Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cysteine4511.0WISP3, COMP, F9, TNFSF11, TNFRSF11B, B2M
2hyaluronic acid45 2412.0PRG4, HAS2, VTN, MMP2, B2M, COMP
3vegf4510.9B2M, WISP3, CXCL10, TNFRSF11A, TNFRSF11B, TNFSF11
4creatinine4510.9TNFSF11, MMP2, CXCL10, CD69, F8, TNFRSF11B
5pge24510.9VTN, HAS2, MMP2
6tyrosine4510.9MMP2, MMP13, CXCL10, F8, HAS2, TNFRSF11B
7hydroxyapatite4510.9TNFRSF11A, TNFSF11, TNFRSF11B, PRG4, VTN, MMP13
8alginate4510.9COMP, MMP13, F9, PRG4, MMP2
9dexamethasone45 50 29 1113.9TNFRSF11B, F8, HAS2, TNFSF11, MMP13, VTN
10procollagen4510.9ZMPSTE24, TNFSF11
11prednisolone45 29 1112.9F9, TNFRSF11B, COMP, F8, MMP13, MMP2
12lipid4510.9VTN, CXCL10, CD69, HFE, COMP, F9
13polyethylene4510.9VTN, TNFRSF11B, TNFSF11, TNFRSF11A
14hydrocortisone45 2 60 1113.9HAS2, F9, TNFRSF11B, HAS1, CXCL10, MMP2
15calcium45 50 11 2413.9F8, TNFRSF11B, TNFSF11, TNFRSF11A, F9, COMP
16estrogen4510.9F9, F8
17glycosaminoglycan4510.9HAS2, CXCL10, MMP13, VTN, HAS1, COMP
18aspartate4510.9COMP, VTN, HFE, F8, B2M
19tgf beta14510.9MMP13, HAS2, TNFRSF11B, COMP, MMP2, F8
20serine4510.9ZMPSTE24, TNFRSF11B, F8, B2M, TNFRSF11A, CD69
21pmma4510.9TNFSF11, TNFRSF11B, VTN, B2M
22cholesterol45 29 11 2413.9F9, TNFRSF11B, F8, B2M, ZMPSTE24, HFE
23cycloheximide4510.9CXCL10
24genistein45 29 60 2 11 2415.9CXCL10, MMP13, MMP2, CD69, TNFRSF11B, B2M
25latex4510.9VTN, PRG4, F8, TNFSF11, F9
26denosumab45 1111.9TNFSF11, TNFRSF11A, TNFRSF11B
27alendronate45 50 1112.8TNFSF11, MMP2, TNFRSF11B, MMP13
28phosphatidylinositol4510.8CXCL10, VTN, CD69, MMP2, TNFRSF11B, MMP13
29urea45 11 2412.8F9, VTN, B2M, TNFSF11, TNFRSF11B
30alanine4510.8F8, TRPV4, HFE, B2M, MMP2, CXCL10
31heparin45 29 11 2413.8VTN, F9, TNFSF11, CD69, MMP13, TNFRSF11B
32nitric oxide45 11 2412.8MMP13, TNFRSF11B, TNFRSF11A, TNFSF11, F8, TRPV4
33infliximab45 50 1112.8CXCL10, TNFSF11, TNFRSF11B, COMP
34heparan sulfate45 2411.8VTN, CXCL10, B2M, TNFRSF11B, TNFSF11
35retinoic acid45 2411.8MMP2, MMP13, CXCL10, B2M, HAS2, VTN
36cyclosporin a45 29 6012.8CD69, B2M, F8, F9, TNFSF11, TNFRSF11B
37glucose4510.8COMP, HAS2
38methotrexate45 50 1112.8CD69, TNFSF11, TNFRSF11B, MMP2, COMP
39pamidronate45 50 1112.7TNFRSF11B, TNFSF11, B2M
40chondroitin sulfate45 2411.7VTN, MMP13, TNFRSF11B, COMP
41chloroquine45 2 50 29 1114.7F9, B2M, CXCL10, VTN
42zinc45 2411.7HFE, MMP13, MMP2, F9, HAS2, TNFSF11
43clodronate45 50 1112.7TNFSF11, MMP13, TNFRSF11B
44matrigel4510.6HAS2, VTN, MMP13, CXCL10
45cyanogen bromide4510.6F9, VTN, MMP13
46ascorbic acid45 2411.6MMP13, TNFSF11, TNFRSF11B, HFE, MMP2
47vitamin d4510.5TNFSF11, TNFRSF11B, B2M, CXCL10, COMP
48silicone4510.5F9, MMP2, VTN
49hcc-14510.4TNFRSF11B, TNFSF11
50hydroxamate4510.2ZMPSTE24, MMP2, MMP13

GO Terms for genes affiliated with Arthropathy

Sources:
16Gene Ontology
See all sources

Cellular components related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.6MMP2, MMP13, CXCL10, PRG4, B2M, F8
2extracellular regionGO:00557610.5VTN, B2M, TNFRSF11B, TNFSF11, F9, COMP
3MHC class I protein complexGO:04261210.5HFE, B2M
4proteinaceous extracellular matrixGO:00557810.4MMP13, VTN, MMP2, COMP, TNFRSF11B
5external side of plasma membraneGO:00989710.2TNFRSF11A, B2M, CD69, CXCL10

Biological processes related to Arthropathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.7VTN, MMP2, MMP13, TNFRSF11B, COMP
2positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.7TNFRSF11A, TNFSF11
3TNFSF11-mediated signaling pathwayGO:07184710.7TNFRSF11A, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFRSF11A, TNFSF11
5immune responseGO:00695510.6TNFSF11, PRG4, HFE, CXCL10, VTN
6cellular response to platelet-derived growth factor stimulusGO:03612010.6HAS2, HAS1
7extracellular polysaccharide biosynthetic processGO:04522610.5HAS2, HAS1
8extracellular matrix assemblyGO:08502910.5HAS1, HAS2
9monocyte chemotaxisGO:00254810.5TNFSF11, TNFRSF11A
10hyaluronan biosynthetic processGO:03021310.4HAS1, HAS2
11mammary gland alveolus developmentGO:06074910.2TNFSF11, TNFRSF11A

Molecular functions related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.5MMP2, MMP13, ZMPSTE24
2hyaluronan synthase activityGO:05050110.4HAS2, HAS1
3polysaccharide bindingGO:03024710.2VTN, PRG4

Products for genes affiliated with Arthropathy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arthropathy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet