MCID: ART023
MIFTS: 66

Arthropathy malady

Summaries for Arthropathy

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Wikipedia:63 An arthropathy is a disease of a joint. more...

MalaCards: Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to arthritis and rheumatoid arthritis. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are TNF Signaling and Collagen biosynthesis and modifying enzymes. The compounds cysteine and hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and t cells, and related mouse phenotypes are skeleton and limbs/digits/tail.

Disease Ontology:8 A bone inflammation disease that is located in joint.

Aliases & Classifications for Arthropathy

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt, 25ICD10
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Classifications:



Aliases & Descriptions:

arthropathy 8 10 44 60
joint ankylosis of the pelvic region and thigh 8
ankylosis of joint of pelvic region and thigh 8
joint ankylosis of the ankle and/or foot 8
ankylosis of joint of ankle and/or foot 8
joint ankylosis of the shoulder region 8
joint ankylosis of the ankle and foot 8
ankylosis of joint of shoulder region 8
arthropathy associated with infection 60
ankylosis of joint of multiple sites 8
ankylosis of ankle and foot joint 8
joint ankylosis of the lower leg 8
joint ankylosis of the upper arm 8
ankylosis of joint of upper arm 8
ankylosis of joint of lower leg 8
joint ankylosis of the forearm 8
ankylosis of joint of forearm 8
ankylosis of lower leg joint 8
ankylosis of multiple joints 8
ankylosis of upper arm joint 8
joint ankylosis of the hand 8
ankylosis of joint of hand 8
ankylosis of forearm joint 8
ankylosis of hand joint 8
infectious arthropathy 8


Related Diseases for Arthropathy

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17GeneCards, 18GeneDecks
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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.7VTN, MMP2, MMP13, CXCL10, CD69, HFE
2rheumatoid arthritis30.6MMP13, COMP, TNFRSF11A, CXCL10, CD69, HFE
3systemic lupus erythematosus30.5COMP, F8, CD69, CXCL10, VTN
4osteoarthritis30.4TNFSF11, TNFRSF11A, COMP, TNFRSF11B, HAS1, HAS2
5neuropathy30.3TRPV4
6psoriasis30.3VTN, CXCL10, CD69
7diabetes mellitus30.2F8, B2M, HFE, VTN
8osteoporosis30.2TNFRSF11A, TNFSF11, TNFRSF11B, MMP13
9synovitis30.2MMP13, CD69, PRG4, B2M, TNFRSF11B, TNFSF11
10myeloma30.2B2M, TNFRSF11B, TNFSF11, TNFRSF11A
11hepatitis30.2CXCL10, HFE, F8, F9
12psoriatic arthritis30.2TNFRSF11B, TNFSF11, COMP
13multiple myeloma30.2TNFSF11, VTN
14leukemia30.1F9, F8, B2M, HFE
15dermatomyositis30.1VTN
16amyloidosis30.0F9, B2M
17connective tissue disease30.0CD69
18sarcoidosis30.0CD69, CXCL10, VTN
19hepatitis c30.0CXCL10, CD69, HFE
20hepatitis b29.9F9, F8, HFE, CXCL10
21obesity29.9HFE, COMP
22sickle cell disease29.9F9
23hemarthrosis29.9F9, F8
24factor vii deficiency29.9F8, F9
25von willebrand's disease29.9F8, F9
26cystic fibrosis29.7F8, TNFRSF11B, F9
27sarcoma29.7F8
28chondrosarcoma29.7MMP13, COMP
29liver cirrhosis29.7F9, TNFRSF11B, HFE, CXCL10, VTN
30gingivitis29.7TNFSF11, TNFRSF11B, MMP13
31multiple sclerosis29.7VTN, CXCL10, CD69
32endometriosis29.7CD69, MMP2, VTN
33primary hyperoxaluria29.7TNFRSF11B, F8, MMP2
34osteomyelitis29.7TNFSF11
35hepatitis a29.6F8
36factor viii deficiency29.6F8, F9
37neurogenic arthropathy10.5
38camptodactyly arthropathy coxa vara pericarditis syndrome10.4
39progressive pseudorheumatoid arthropathy of childhood10.4
40lupus erythematosus10.4
41pericarditis10.4
42torg winchester syndrome10.4
43pseudogout10.3
44reactive arthritis10.3
45syringomyelia10.3
46behcet's syndrome arthropathy10.3
47transient arthropathy10.3
48enthesopathy10.3
49gout10.3
50hemochromatosis10.2

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to arthropathy

Clinical Features for Arthropathy

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Drugs & Therapeutics for Arthropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Arthropathy

Drug clinical trials:

Search ClinicalTrials for Arthropathy

Search NIH Clinical Center for Arthropathy

Search CenterWatch for Arthropathy

Genetic Tests for Arthropathy

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Anatomical Context for Arthropathy

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Arthropathy:

32
Bone, T cells, Heart, Spinal cord, Lung, Liver, Skin, Bone marrow, Monocytes, Cervix, Testes, Uterus, Ovary, Pituitary, Eye

FMA organs/tissues related to Arthropathy:

14
Joint

Animal Models for Arthropathy or affiliated genes

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36MGI
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Publications for Arthropathy

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50PubMed
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Articles related to Arthropathy:

(show top 50)    (show all 776)
idTitleAuthorsYear
1
Agonistic anti-human Fas monoclonal antibody induces fibroblast-like synoviocyte apoptosis in haemophilic arthropathy: potential therapeutic implications. (24308756)
2014
2
Early results with use of the midfoot fusion bolt in Charcot arthropathy. (23318099)
2013
3
IL-6 receptor antagonist as adjunctive therapy with clotting factor replacement to protect against bleeding-induced arthropathy in hemophilia. (23413986)
2013
4
Large joint destructive arthropathy and tumoral calcinosis associated to primary oxalosis: case report and literature review. (23570963)
2013
5
A comparative study of zoledronic acid and once weekly Alendronate in the management of acute Charcot arthropathy of foot in patients with diabetes mellitus. (23776862)
2013
6
HTLV-1-associated arthropathy treated with anti-TNF-alpha agent. (24289962)
2013
7
Treatment of severe cuff tear arthropathy with the humeral head resurfacing arthroplasty: two-year minimum follow-up. (22743073)
2013
8
Radiographic features of rhupus arthropathy. (24334598)
2013
9
Shoulder arthroplasty in alkaptonuric arthropathy: a clinical case report and literature review. (22447274)
2012
10
Comment on: arthropathy with infiltrate IgG4-positive plasma cells in synovium. (22826306)
2012
11
Inflammatory and noninflammatory arthropathy in patients with 18q deletion syndrome. (22157270)
2012
12
Rotator cuff tear arthropathy: evaluation, diagnosis, and treatment: AAOS exhibit selection. (22438007)
2012
13
Connective tissue diseases: SLE-associated arthropathy: truly a benign entity? (23147902)
2012
14
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
15
Haemophilic arthropathy: the usefulness of intra-articular oxytetracycline (synoviorthesis) in the treatment of chronic synovitis in children. (21070486)
2011
16
Modified Eden-Lange procedure for trapezius paralysis with ipsilateral rotator cuff-tear arthropathy: a case report. (22262391)
2011
17
Total knee replacement in patients with end-stage haemophilic arthropathy: 25-year results. (20675751)
2010
18
Charcot ankle arthropathy in CMT1A exacerbated by type 2 diabetes mellitus. (20481284)
2010
19
End-stage hemophilic arthropathy in a patient from a developing nation. (20808176)
2010
20
Increased bone resorption is implicated in the pathogenesis of bone loss in hemophiliacs: correlations with hemophilic arthropathy and HIV infection. (19488753)
2010
21
Importance of close surveillance for Charcot arthropathy in diabetic patients presenting to the emergency department with low-energy foot injuries. (20562154)
2010
22
Interdisciplinary management of total knee replacement in a haemophilia patient with high-titre inhibitor and severe arthropathy complicated by an aneurysmatic bone cyst. (19149863)
2009
23
Atherogenic serum lipid profile is an independent predictor for gouty flares in patients with gouty arthropathy. (19151029)
2009
24
Current approaches in haemophilic arthropathy of the hip. (19298385)
2009
25
Orthopaedic management of haemophilia arthropathy of the ankle. (18510538)
2008
26
Prevention of haemophilic arthropathy during childhood. May common orthopaedic management be extrapolated from patients without inhibitors to patients with inhibitors? (19134036)
2008
27
Prevention of haemophilic arthropathy in haemophilic children with inhibitors. (19134025)
2008
28
Acute gouty arthropathy after total knee arthroplasty. (18836601)
2008
29
Economic evaluation of major knee surgery with recombinant activated factor VII in hemophilia patients with high titer inhibitors and advanced knee arthropathy: exploratory results via literature-based modeling. (18234151)
2008
30
Arthropathy of neonatal onset multisystem inflammatory disease (NOMID/CINCA). (17136361)
2007
31
Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women. (16551465)
2006
32
The role of ring external fixation in Charcot foot arthropathy. (17097520)
2006
33
Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy. (15188380)
2004
34
Periarticular calcifications and arthropathy as the first manifestation of polymyositis. (14611132)
2003
35
Radiofrequency neurolysis for facet arthropathy: a retrospective case series and review of the literature. (17134469)
2002
36
Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies. (9566800)
1998
37
Proximal tibial valgus osteotomy for hemophilic arthropathy of the knee. (1538887)
1992
38
Radiocolloids in the management of hemophilic arthropathy in children and adolescents. (1997228)
1991
39
Complications of axial arthropathies. (2114600)
1990
40
Late presentation and microcrystalline arthropathy in primary hyperoxaluria. (2612083)
1989
41
Nonsteroidal anti-inflammatory drugs in the treatment of hemophilic arthropathy. (7072708)
1982
42
Arthrographic pseudoloosening of Marmor total knee in hemophilic arthropathy: report of a case. (7285410)
1981
43
Crystal-induced arthropathy. Gout and pseudogout. (490862)
1979
44
Cartilage in hemophilic arthropathy. Ultrastructural and microanalytical studies. (946396)
1976
45
Charcot arthropathy secondary to amyloid neuropathy. (946252)
1976
46
Arthrocentesis of the knee in acute hemophilic arthropathy. (1154758)
1975
47
A roentgenologically distinctive arthropathy in some patients with the pseudogout syndrome. (5431507)
1970
48
Inorganic pyrophosphate in plasma, urine, and synovial fluid of patients with pyrophosphate arthropathy (chondrocalcinosis or pseudogout). (4097282)
1970
49
Hemophilic arthropathy. (6048906)
1967
50
Acute hypertrophic osteo-arthropathy associated with subacute bacterial endocarditis. (13080911)
1953

Genetic Variations for Arthropathy

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Expression for genes affiliated with Arthropathy

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Pathways for genes affiliated with Arthropathy

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55SinoBiological, 52R&D Systems, 53Reactome, 51QIAGEN, 12EMD Millipore, 37NCBI BioSystems Database
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Pathways related to Arthropathy according to GeneCards/GeneDecks:

(show all 11)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.5B2M, TNFRSF11B, TNFSF11, TNFRSF11A
2
Hide members
10.5VTN, MMP2, MMP13, F8, F9, COMP
3
Hide members
10.5VTN, MMP2, MMP13, CXCL10, PRG4
4
Transcription Role of VDR in regulation of genes involved in osteoporosis
Hide members
10.5TNFRSF11A, TNFSF11, TNFRSF11B
5
Hide members
10.5TNFRSF11B, TNFSF11, TNFRSF11A
610.5TNFRSF11A, TNFSF11, TNFRSF11B
710.5TNFRSF11B, TNFSF11
8
Hide members
10.5MMP2, MMP13
9
Hide members
10.5HAS2, HAS1
1010.5HAS2, HAS1
11
Cell adhesion ECM remodeling
Hide members
10.5MMP13, MMP2, VTN

Compounds for genes affiliated with Arthropathy

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44Novoseek, 24HMDB, 49PharmGKB, 28IUPHAR, 11DrugBank, 2BitterDB, 59Tocris Bioscience
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Compounds related to Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 116)
idCompoundScoreTop Affiliating Genes
1cysteine4411.0WISP3, COMP, F9, TNFSF11, TNFRSF11B, B2M
2hyaluronic acid44 2412.0PRG4, HAS2, VTN, MMP2, B2M, COMP
3vegf4410.9B2M, WISP3, CXCL10, TNFRSF11A, TNFRSF11B, TNFSF11
4creatinine4410.9TNFSF11, MMP2, CXCL10, CD69, F8, TNFRSF11B
5pge24410.9VTN, HAS2, MMP2
6tyrosine4410.9MMP2, MMP13, CXCL10, F8, HAS2, TNFRSF11B
7hydroxyapatite4410.9TNFRSF11A, TNFSF11, TNFRSF11B, PRG4, VTN, MMP13
8alginate4410.9COMP, MMP13, F9, PRG4, MMP2
9dexamethasone44 49 28 1113.9TNFRSF11B, F8, HAS2, TNFSF11, MMP13, VTN
10procollagen4410.9ZMPSTE24, TNFSF11
11prednisolone44 28 1112.9F9, TNFRSF11B, COMP, F8, MMP13, MMP2
12lipid4410.9VTN, CXCL10, CD69, HFE, COMP, F9
13polyethylene4410.9VTN, TNFRSF11B, TNFSF11, TNFRSF11A
14hydrocortisone44 2 59 1113.9HAS2, F9, TNFRSF11B, HAS1, CXCL10, MMP2
15calcium44 49 11 2413.9F8, TNFRSF11B, TNFSF11, TNFRSF11A, F9, COMP
16estrogen4410.9F9, F8
17glycosaminoglycan4410.9HAS2, CXCL10, MMP13, VTN, HAS1, COMP
18aspartate4410.9COMP, VTN, HFE, F8, B2M
19tgf beta14410.9MMP13, HAS2, TNFRSF11B, COMP, MMP2, F8
20serine4410.9ZMPSTE24, TNFRSF11B, F8, B2M, TNFRSF11A, CD69
21pmma4410.9TNFSF11, TNFRSF11B, VTN, B2M
22cholesterol44 28 11 2413.9F9, TNFRSF11B, F8, B2M, ZMPSTE24, HFE
23cycloheximide4410.9CXCL10
24genistein44 28 59 2 11 2415.9CXCL10, MMP13, MMP2, CD69, TNFRSF11B, B2M
25latex4410.9VTN, PRG4, F8, TNFSF11, F9
26denosumab44 1111.9TNFSF11, TNFRSF11A, TNFRSF11B
27alendronate44 49 1112.8TNFSF11, MMP2, TNFRSF11B, MMP13
28phosphatidylinositol4410.8CXCL10, VTN, CD69, MMP2, TNFRSF11B, MMP13
29urea44 11 2412.8F9, VTN, B2M, TNFSF11, TNFRSF11B
30alanine4410.8F8, TRPV4, HFE, B2M, MMP2, CXCL10
31heparin44 28 11 2413.8VTN, F9, TNFSF11, CD69, MMP13, TNFRSF11B
32nitric oxide44 11 2412.8MMP13, TNFRSF11B, TNFRSF11A, TNFSF11, F8, TRPV4
33infliximab44 49 1112.8CXCL10, TNFSF11, TNFRSF11B, COMP
34heparan sulfate44 2411.8VTN, CXCL10, B2M, TNFRSF11B, TNFSF11
35retinoic acid44 2411.8MMP2, MMP13, CXCL10, B2M, HAS2, VTN
36cyclosporin a44 28 5912.8CD69, B2M, F8, F9, TNFSF11, TNFRSF11B
37glucose4410.8COMP, HAS2
38methotrexate44 49 1112.8CD69, TNFSF11, TNFRSF11B, MMP2, COMP
39pamidronate44 49 1112.7TNFRSF11B, TNFSF11, B2M
40chondroitin sulfate44 2411.7VTN, MMP13, TNFRSF11B, COMP
41chloroquine44 2 49 28 1114.7F9, B2M, CXCL10, VTN
42zinc44 2411.7HFE, MMP13, MMP2, F9, HAS2, TNFSF11
43clodronate44 49 1112.7TNFSF11, MMP13, TNFRSF11B
44matrigel4410.6HAS2, VTN, MMP13, CXCL10
45cyanogen bromide4410.6F9, VTN, MMP13
46ascorbic acid44 2411.6MMP13, TNFSF11, TNFRSF11B, HFE, MMP2
47vitamin d4410.5TNFSF11, TNFRSF11B, B2M, CXCL10, COMP
48silicone4410.5F9, MMP2, VTN
49hcc-14410.4TNFRSF11B, TNFSF11
50hydroxamate4410.2ZMPSTE24, MMP2, MMP13

GO Terms for genes affiliated with Arthropathy

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16Gene Ontology
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Cellular components related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.6MMP2, MMP13, CXCL10, PRG4, B2M, F8
2extracellular regionGO:00557610.5VTN, B2M, TNFRSF11B, TNFSF11, F9, COMP
3MHC class I protein complexGO:04261210.5HFE, B2M
4proteinaceous extracellular matrixGO:00557810.4MMP13, VTN, MMP2, COMP, TNFRSF11B
5external side of plasma membraneGO:00989710.2TNFRSF11A, B2M, CD69, CXCL10

Biological processes related to Arthropathy according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1extracellular matrix organizationGO:03019810.7TNFRSF11B, MMP2, VTN, COMP, MMP13
2positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signalingGO:07184810.7TNFSF11, TNFRSF11A
3TNFSF11-mediated signaling pathwayGO:07184710.7TNFRSF11A, TNFSF11
4positive regulation of fever generation by positive regulation of prostaglandin secretionGO:07181210.7TNFRSF11A, TNFSF11
5immune responseGO:00695510.6TNFSF11, PRG4, HFE, CXCL10, VTN
6extracellular polysaccharide biosynthetic processGO:04522610.6HAS1, HAS2
7cellular response to platelet-derived growth factor stimulusGO:03612010.5HAS1, HAS2
8extracellular matrix assemblyGO:08502910.5HAS2, HAS1
9monocyte chemotaxisGO:00254810.5TNFRSF11A, TNFSF11
10hyaluronan biosynthetic processGO:03021310.4HAS1, HAS2
11mammary gland alveolus developmentGO:06074910.2TNFRSF11A, TNFSF11

Molecular functions related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1metalloendopeptidase activityGO:00422210.5MMP2, MMP13, ZMPSTE24
2hyaluronan synthase activityGO:05050110.4HAS2, HAS1
3polysaccharide bindingGO:03024710.2VTN, PRG4

Products for genes affiliated with Arthropathy

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Sources for Arthropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet