MCID: ART023
MIFTS: 63

Arthropathy malady

Bone diseases category
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Summaries for Arthropathy

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Sources:
8Disease Ontology, 65Wikipedia, 33MalaCards
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Wikipedia:65 An arthropathy is a disease of a joint. more...

MalaCards: Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to arthritis and hemochromatosis. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The compounds pentosidine and hcc-1 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and t cells, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:8 A bone inflammation disease that is located in joint.

Aliases & Classifications for Arthropathy

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 58SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

arthropathy 8 10 45 62
joint ankylosis of the pelvic region and thigh 8
ankylosis of joint of pelvic region and thigh 8
joint ankylosis of the ankle and/or foot 8
ankylosis of joint of ankle and/or foot 8
joint ankylosis of the shoulder region 8
joint ankylosis of the ankle and foot 8
ankylosis of joint of shoulder region 8
arthropathy associated with infection 62
ankylosis of joint of multiple sites 8
ankylosis of ankle and foot joint 8
joint ankylosis of the lower leg 8
joint ankylosis of the upper arm 8
ankylosis of joint of lower leg 8
ankylosis of joint of upper arm 8
joint ankylosis of the forearm 8
ankylosis of joint of forearm 8
ankylosis of lower leg joint 8
ankylosis of multiple joints 8
ankylosis of upper arm joint 8
joint ankylosis of the hand 8
ankylosis of joint of hand 8
ankylosis of forearm joint 8
ankylosis of hand joint 8
infectious arthropathy 8


Related Diseases for Arthropathy

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17GeneCards, 18GeneDecks
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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.5HFE, COMP, MMP2, TNFSF11, WISP3, B2M
2hemochromatosis30.5HFE, B2M
3rheumatoid arthritis30.4B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
4multiple myeloma30.2TNFRSF11B, TNFSF11, B2M
5myeloma30.2B2M, TNFSF11, TNFRSF11B
6osteoarthritis30.2HFE, TNFRSF11B, COMP, PRG4, MMP2, TNFSF11
7psoriatic arthritis30.1TNFSF11, COMP, TNFRSF11B
8amyloidosis30.1B2M, F9
9ankylosing spondylitis30.1TNFSF11, TNFRSF11B
10synovitis30.0TNFRSF11B, COMP, B2M, TNFSF11, PRG4
11aneurysm30.0MMP2, TNFRSF11B
12gingivitis29.7TNFRSF11B, TNFSF11
13primary hyperoxaluria29.6TNFSF11, HFE, TNFRSF11B, B2M
14hemophilic arthropathy10.9
15camptodactyly arthropathy coxa vara pericarditis syndrome10.6
16progressive pseudorheumatoid arthropathy of childhood10.5
17neurogenic arthropathy10.5
18torg winchester syndrome10.4
19lupus erythematosus10.4
20pericarditis10.4
21reactive arthritis10.4
22systemic lupus erythematosus10.4
23syringomyelia10.4
24behcet's syndrome arthropathy10.4
25pseudogout10.4
26transient arthropathy10.3
27enthesopathy10.3
28gout10.3
29ochronosis10.3
30neuropathy10.3
31cervicitis10.2
32psoriasis10.2
33hemophilia10.2
34acromegaly10.2
35diabetes mellitus10.2
36osteoporosis10.2
37distal arthrogryposis10.2
38alkaptonuria10.2
39juvenile rheumatoid arthritis10.2
40hepatitis10.2
41inflammatory bowel disease10.2
42digital arthropathy-brachydactyly, familial10.2
43atlantoaxial subluxation10.2
44leukemia10.1
45vasculitis10.1
46chondrocalcinosis 210.1
47periapical granuloma10.1TNFSF11
48ankylosis10.1
49hepatitis c10.1
50hidradenitis suppurativa10.1

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to arthropathy

Symptoms for Arthropathy

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Drugs & Therapeutics for Arthropathy

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Arthropathy

Search NIH Clinical Center for Arthropathy

Genetic Tests for Arthropathy

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Anatomical Context for Arthropathy

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Sources:
33MalaCards, 14FMA
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MalaCards organs/tissues related to Arthropathy:

33
Bone, T cells, Heart, Spinal cord, Lung, Liver, Skin, Bone marrow, Monocytes, Cervix, Testes, Uterus, Ovary, Pituitary, Eye

FMA organs/tissues related to Arthropathy:

14
Joint

Animal Models for Arthropathy or affiliated genes

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Sources:
37MGI
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MGI Mouse Phenotypes related to Arthropathy:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFSF11, TNFRSF11B, PRG4, COMP, HFE
2MP:00053907.9TNFSF11, TNFRSF11B, MMP2, PRG4, COMP
3MP:00053767.8TRPV4, HFE, MMP2, TNFSF11, B2M, F9
4MP:00053857.7F9, B2M, TNFRSF11B, MMP2, PRG4, TRPV4
5MP:00053977.3F9, B2M, TNFSF11, TNFRSF11B, MMP2, HFE
6MP:00053787.1B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
7MP:00107687.1F9, B2M, TNFSF11, TNFRSF11B, MMP2, PRG4
8MP:00053877.0HFE, COMP, MMP2, TNFRSF11B, TNFSF11, B2M

Publications for Arthropathy

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Sources:
52PubMed
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Articles related to Arthropathy:

(show top 50)    (show all 764)
idTitleAuthorsYear
1
Progression of haemophilic arthropathy in children: a Lithuanian--Danish comparative study. (23167920)
2013
2
Primary knee arthrodesis for severe crystalline arthropathy. (24278911)
2013
3
Risk factors for dislocation arthropathy after Latarjet procedure: a long-term study. (23508865)
2013
4
Acute charcot arthropathy of the wrist in a diabetic patient. (22961091)
2013
5
Jaccoud's arthropathy. (23290493)
2013
6
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. (23623735)
2013
7
Rapidly destructive arthropathy of the hip joint in patients with rheumatoid arthritis. (22691675)
2012
8
Occult erosions in Jaccoud arthropathy. (22832301)
2012
9
Atypical case of hypertrophic osteo-arthropathy. (23029954)
2012
10
Reverse total shoulder arthroplasty for cuff tear arthropathy: the clinical effect of deltoid lengthening and center of rotation medialization. (22056324)
2012
11
Joint distraction results in clinical and structural improvement of haemophilic ankle arthropathy: a series of three cases. (22530605)
2012
12
Visualization of amyloid arthropathy in light-chain systemic amyloidosis on F-18 FDG PET/CT scan. (21157212)
2011
13
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
14
Usefulness of wireless capsule endoscopy for detecting inflammatory bowel disease in children presenting with arthropathy. (21643650)
2011
15
Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score. (21070482)
2011
16
Charcot arthropathy of the knee. A case-based review. (21057837)
2011
17
Bypassing agent prophylaxis for preventing arthropathy in patients with inhibitors. (19702885)
2010
18
Midtarsal arthrodesis in the treatment of Charcot midfoot arthropathy. (19122082)
2009
19
Use of platelet-rich concentrate and bone marrow aspirate in high-risk patients with Charcot arthropathy of the foot. (19254506)
2009
20
Acute gouty arthropathy mimicking infection after total knee arthroplasty. (19627909)
2009
21
Refinement of a sonographic protocol for assessment of haemophilic arthropathy. (19493019)
2009
22
The outcome of cementless total hip arthroplasty in haemophilic hip arthropathy. (19444974)
2009
23
Complications in the management of Charcot spinal arthropathy. (19769521)
2009
24
Haemophilic arthropathy from A to Z. Introduction. (18494685)
2008
25
Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment. (19134026)
2008
26
Magnetic resonance imaging in early stage charcot arthropathy: correlation of imaging findings and clinical symptoms. (18948232)
2008
27
Charcot arthropathy risk elevation in the obese diabetic population. (18954849)
2008
28
Orthopaedic management of haemophilia arthropathy of the ankle. (18510538)
2008
29
The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy. (18612836)
2008
30
Sonography for assessment of haemophilic arthropathy in children: a systematic protocol. (17498079)
2007
31
Rotator cuff tear arthropathy. (17548883)
2007
32
Gouty arthropathy of the cervical spine in a young adult. (17475601)
2007
33
Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women. (16551465)
2006
34
Calcium pyrophosphate dihydrate-crystal induced arthropathy]. (14991274)
2004
35
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
36
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. (10782809)
2000
37
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
38
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
39
The arthropathy of the Muckle-Wells syndrome. (8000753)
1994
40
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
41
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
42
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
43
Radiographic and therapeutic aspects of neurogenic arthropathy. (1297567)
1992
44
Resorptive arthropathy and rib erosions in mixed connective tissue disease. (2359089)
1990
45
Arthropathy in von Willebrand's disease. (2787227)
1989
46
Idiopathic neurogenic arthropathy. (4044822)
1985
47
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
48
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. (6681882)
1983
49
Hemophilic arthropathy. (6048906)
1967
50
Hemophilic arthropathy. (13775889)
1960

Variations for Arthropathy

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Expression for genes affiliated with Arthropathy

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Pathways for genes affiliated with Arthropathy

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50PathCards, 38NCBI BioSystems Database, 60Thomson Reuters, 57SinoBiological, 54R&D Systems
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Compounds for genes affiliated with Arthropathy

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Sources:
45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 61Tocris Bioscience, 29IUPHAR, 3BitterDB
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Compounds related to Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pentosidine459.7B2M, COMP
2hcc-1459.5TNFSF11, TNFRSF11B
3denosumab45 1110.5TNFRSF11B, TNFSF11
4teriparatide45 1110.4TNFSF11, TNFRSF11B
5polyethylene459.4TNFSF11, TNFRSF11B
6hyaluronic acid45 2410.3B2M, COMP, PRG4, MMP2
7ibandronate45 1110.3TNFRSF11B, TNFSF11
8latex459.3PRG4, TNFSF11, F9
9zoledronic acid459.2TNFRSF11B, TNFSF11, MMP2
10alendronate45 51 1111.2TNFSF11, TNFRSF11B, MMP2
11ns 39845 6110.2MMP2, TNFRSF11B, TNFSF11
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide459.2MMP2, TNFRSF11B, TNFSF11
13hydroxyapatite459.2TNFRSF11B, PRG4, TNFSF11
14alginate459.2COMP, F9, MMP2, PRG4
15pamidronate45 51 1111.2TNFSF11, B2M, TNFRSF11B
16celecoxib45 61 29 51 24 1114.2MMP2, TNFRSF11B, TNFSF11
17pmma459.1TNFSF11, TNFRSF11B, B2M
1825-hydroxyvitamin d459.1TNFSF11, TNFRSF11B, B2M
19phosphorus459.1TNFSF11, B2M, TNFRSF11B
20azathioprine45 3 51 1112.1MMP2, TNFRSF11B, TNFSF11
21deoxypyridinoline459.0COMP, TNFRSF11B, TNFSF11
22etanercept45 51 1111.0COMP, TNFRSF11B, TNFSF11
23infliximab45 51 1111.0COMP, TNFSF11, TNFRSF11B
24p003458.9TNFRSF11B, HFE, COMP
25tgf beta1458.9TNFRSF11B, MMP2, COMP
26hydrocortisone45 3 61 1111.9TNFRSF11B, MMP2, F9
27vitamin k2458.8TNFRSF11B, TNFSF11
28ascorbic acid45 249.7TNFSF11, HFE, MMP2, TNFRSF11B
29procollagen458.7MMP2, TNFRSF11B, TNFSF11, COMP
30heparan sulfate45 249.7B2M, TNFRSF11B, TNFSF11
31genistein45 29 61 3 24 1113.7TNFSF11, MMP2, TNFRSF11B, B2M
32methotrexate51 45 1110.7TNFSF11, TNFRSF11B, MMP2, COMP
33pge2458.7TNFSF11, B2M, TNFRSF11B, MMP2
34alanine458.6B2M, TRPV4, MMP2, F9, HFE
35prednisolone45 29 1110.6MMP2, COMP, F9, TNFRSF11B
36vitamin d458.6TNFSF11, TNFRSF11B, COMP, B2M
37urea45 24 1110.5TNFRSF11B, B2M, F9, TNFSF11
38sodium45 249.5TRPV4, TNFSF11, B2M, TNFRSF11B
39vegf458.4MMP2, TNFRSF11B, WISP3, B2M, TNFSF11
40cyclosporin a45 29 6110.4TNFRSF11B, TNFSF11, B2M, F9
41cycloheximide458.4B2M, TNFSF11, TNFRSF11B, MMP2
42glucose457.9B2M, F9, TNFRSF11B, HFE, COMP
43aspartate457.8HFE, COMP, F9, B2M, MMP2, TNFRSF11B
44testosterone45 61 24 1110.8B2M, TNFSF11, F9, TNFRSF11B, MMP2, HFE
45estrogen457.8B2M, F9, TNFSF11, TNFRSF11B, MMP2, HFE
46creatinine457.7MMP2, F9, COMP, TNFRSF11B, TNFSF11, B2M
47tyrosine457.7TNFRSF11B, TRPV4, MMP2, TNFSF11, F9, HFE
48lipid457.4HFE, F9, TNFSF11, TNFRSF11B, COMP
49calcium45 51 24 1110.3COMP, MMP2, TNFRSF11B, TNFSF11, F9, B2M
50cysteine456.9HFE, F9, WISP3, TNFSF11, MMP2, B2M

GO Terms for genes affiliated with Arthropathy

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16Gene Ontology
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Cellular components related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.3HFE, B2M
2proteinaceous extracellular matrixGO:0055788.8COMP, MMP2, TNFRSF11B
3extracellular spaceGO:0056157.2COMP, B2M, WISP3, TNFSF11, TNFRSF11B, MMP2
4extracellular regionGO:0055767.2COMP, TNFSF11, MMP2, F9, B2M, TNFRSF11B

Biological processes related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell mediated cytotoxicityGO:0019169.5HFE, B2M
2immune responseGO:0069559.2HFE, PRG4, TNFSF11
3extracellular matrix organizationGO:0301988.5COMP, MMP2, TNFRSF11B

Products for genes affiliated with Arthropathy

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Sources for Arthropathy

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet