Arthropathy malady

Wikipedia: An arthropathy is a disease of a joint.⁴⁴ more...

MalaCards: Arthropathy, also known as joint ankylosis of the pelvic region and thigh (disorder), is related to progressive pseudorheumatoid arthropathy of childhood and hemophilic arthropathy. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are Cell adhesion_ECM remodeling and Cell adhesion ECM remodeling. The drugs cloxacillin sodium and loracarbef and the compounds cyclophosphamide and glycosaminoglycan have been mentioned in the context of this disorder. Affiliated tissues include joint, liver and monocytes, and related mouse phenotypes are respiratory system and craniofacial.

Disease Ontology: A bone inflammation disease that is located in joint.⁶

Aliases & Descriptions:

arthropathy 6 7 8 32 43 joint ankylosis of the pelvic region and thigh (disorder) 6 joint ankylosis of the ankle and/or foot (disorder) 6 ankylosis of joint of ankle and/or foot (disorder) 6 joint ankylosis of the shoulder region (disorder) 6 ankylosis of joint of shoulder region (disorder) 6 ankylosis of joint of multiple sites (disorder) 6 joint ankylosis of the pelvic region and thigh 6 ankylosis of joint of pelvic region and thigh 6 joint ankylosis of the upper arm (disorder) 6 joint ankylosis of the lower leg (disorder) 6 ankylosis of joint of lower leg (disorder) 6 ankylosis of joint of upper arm (disorder) 6 joint ankylosis of the forearm (disorder) 6 ankylosis of joint of forearm (disorder) 6 joint ankylosis of the shoulder region 6 arthropathy associated with infection 43

joint ankylosis of the ankle and foot 6 ankylosis of joint of shoulder region 6 ankylosis of joint of hand (disorder) 6 ankylosis of joint of multiple sites 6 ankylosis of ankle and foot joint 6 joint ankylosis of the upper arm 6 joint ankylosis of the lower leg 6 joint ankylosis of the forearm 6 ankylosis of multiple joints 6 ankylosis of upper arm joint 6 ankylosis of lower leg joint 6 joint ankylosis of the hand 6 ankylosis of forearm joint 6 ankylosis of hand joint 6 infectious arthropathy 6 ankylosis 43

Diseases related to arthropathy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 969)

id	Related Disease	Score	Top Affiliating Genes
1	progressive pseudorheumatoid arthropathy of childhood	33.3	IGF1, SRF, WISP3
2	hemophilic arthropathy	32.7	F9, F8, PTGS2, COMP, HFE
3	spondyloepiphyseal dysplasia tarda	31.2	IGF1, TRAPPC2, SRF, COL2A1, WISP3
4	reactive arthritis	30.1	BPI, CD79A, IFNB1, HLA-B, CRP, COMP
5	arthritis	29.7	MMP3, IL1B, IL6, IL8, TNF, TNFSF11
6	hemochromatosis	29.1	B2M, HLA-B, HFE, TF, TFR2, HAMP
7	pericarditis	28.8	VTN, IL1B, IL2, IL6, IL8, HSPG2
8	joint disorders	28.6	MMP3, IL1R1, IL1RAPL2, IL1RN, IL6, TNF
9	pseudogout	28.3	MMP1, IL1RAPL2, ANKH
10	ankylosing spondylitis	28.2	BGLAP, CD79A, MMP3, IL1R1, IL1RAPL2, IL1RN
11	rheumatoid arthritis	28.0	CIITA, MICA, MIF, IL10, IL1B, IL1RN
12	calcinosis	27.7	KITLG, LMNA, ZMPSTE24, FGF23, ANKH, ALPL
13	ankylosis	27.5	BMP2, ANKH, HLA-B, TNFRSF11B
14	hepatitis	26.9	FAS, IFNB1, F2, KRT18, HFE, TF
15	carpal tunnel syndrome	26.6	B2M, IL1B, IL2, IL6, CCL3, TAC1
16	psoriatic arthritis	26.2	IL10, IL1B, IL1RAPL2, IL1RN, IL6, TNF
17	familial adenomatous polyposis	26.0	BMP6, CD79A, IL2, ALPPL2, HSPG2, PTGS2
18	multiple sclerosis	26.0	MICA, IL1B, IL1RN, IL2RA, IL4R, IFNG
19	iron overload	26.0	BMP6, B2M, FTH1, FTL, F2, ALPP
20	periodontitis	25.7	MMP1, MMP13, MMP3, IL10, IL1B, IL1R1
21	tuberculosis	25.6	IL10, IL1B, IL1RN, IL4, IFNG, TNF
22	paralysis	25.5	MIF, IL10, IL1B, ANKH, F2, HSPG2
23	collagen disease	25.1	IL10, IL2RA, IL6, IFNG, TNF, CTLA4
24	human t-cell leukemia virus type 1	25.1	IL15, IL1B, IL2, IL2RA, IL6, FAS
25	hepatitis b	25.1	IL10, IL2RA, IFNG, F2, TRB@, CTLA4
26	gout	25.0	BCKDHA, UMOD, S100A9, CD79A, IL1B, IL1R1
27	hemophilia	23.2	CIITA, IL10, IL1B, IL4, IL6, IFNG
28	schistosomiasis	22.9	BMP6, CHI3L1, CD79A, MMP2, IL10, IL2
29	neutropenia	22.2	KITLG, CD79A, IL10, IL1B, IL1R1, IL1RN
30	inflammatory bowel disease	21.1	RETN, BPI, BMP7, BGLAP, CIITA, CHI3L1
31	dermatomyositis	20.8	VTN, BMP6, S100A8, S100A9, MICA, IL10
32	spondylitis	20.0	BMP2, BMP6, BMP7, BGLAP, CHI3L1, S100A8
33	osteoarthritis	20.0	RETN, VTN, BPI, BMP2, BMP6, BMP7
34	polyposis	20.0	KITLG, LMNA, BMP2, BMP6, CD79A, MMP1
35	systemic lupus erythematosus	18.7	VTN, CIITA, CHI3L1, S100A8, S100A9, CD79A
36	t-cell leukemia	18.5	KITLG, BMP6, B2M, CD79A, IL10, IL15
37	psoriasis	17.7	RETN, KITLG, VTN, BGLAP, CIITA, CHI3L1
38	lupus erythematosus	15.1	RETN, VTN, BMP6, BGLAP, CIITA, CHI3L1
39	bullous keratopathy	14.0	BMP2, MMP2, IGF1, TIMP1, DCN
40	keratopathy	14.0	BMP2, MMP2, IGF1, TIMP1, TAC1, DCN
41	erythema nodosum, idiopathic	14.0	S100A8, S100A9, TNF, NOD2
42	spondylarthropathy	13.9	S100A8, S100A9, B2M, IL1RAPL2, TNF, CRP
43	refractive error	13.9	MMP1, MMP13, MMP2, MMP3, TIMP1
44	hyperferritinemia-cataract syndrome	13.9	FTL, CRP, HFE, TF
45	aortic valve stenosis	13.9	BMP2, TNFRSF11B, TNFSF11, HGD
46	chronic apical periodontitis	13.9	TNFRSF11B, TNFSF11, CRP
47	odontogenic myxoma	13.9	MMP1, MMP2, ACAN, DCN
48	siderosis	13.9	FTH1, IGF1, HFE, TF
49	aneurysm disease	13.9	MMP1, MMP2, MMP3, ALOX5, TNFRSF11B, CRP
50	keratoconus	13.9	BMP2, MMP1, MMP2, MMP3, IL1B, IGF1

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cloxacillin, cloxacillin sodium, loracarbef

MalaCards organs/tissues related to arthropathy:

²²

FMA organs/tissues related to arthropathy:

¹¹

MGI Mouse Phenotypes related to arthropathy:

²⁵ (show all 26)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	respiratory system phenotype	MP:0005388	10.5	IVNS1ABP, FGF23, ANKH, ALPL, TRD@, TRPV4
2	craniofacial phenotype	MP:0005382	10.0	ACAN, COL2A1, HSPG2, ALPL, ANKH, ZMPSTE24
3	renal/urinary system phenotype	MP:0005367	9.8	NLRP3, COL2A1, TGM2, TAC1, DCN, HGD
4	hematopoietic system phenotype	MP:0005397	9.3	MIF, TFR2, HAMP, TGM2, NOD2, TNFSF11
5	hearing/vestibular/ear phenotype	MP:0005377	9.2	HSPG2, TRPV4, TNFRSF11B, COL2A1, IGF1, ANKH
6	no phenotypic analysis	MP:0003012	9.0	HAS2, TFR2, TGM2, SRF, PTGS2, TRG@
7	adipose tissue phenotype	MP:0005375	9.0	ALPL, GH1, TNF, TNFRSF1B, PTGS2, ALOX5
8	endocrine/exocrine gland phenotype	MP:0005379	8.9	SLC26A3, LTA, PHB2, CTLA4, HOXD9, IFNG
9	limbs/digits/tail phenotype	MP:0005371	8.6	HOXD9, TNFRSF11B, TNFSF11, COMP, COL2A1, LTA
10	nervous system phenotype	MP:0003631	8.2	HOXD9, HLA-C, TRPV4, TRB@, TNFRSF1B, COL2A1
11	digestive/alimentary phenotype	MP:0005381	8.1	KITLG, TRB@, CTLA4, NOD2, COL2A1, ACAN
12	skeleton phenotype	MP:0005390	8.0	KITLG, LMNA, BMP2, BMP6, BMP7, ZMPSTE24
13	liver/biliary system phenotype	MP:0005370	7.7	HSPG2, GH1, TRD@, TRB@, CTLA4, NLRP3
14	integument phenotype	MP:0010771	7.6	TRG@, TRB@, TNFRSF1B, TNFSF11, CTLA4, NLRP3
15	muscle phenotype	MP:0005369	7.6	HOXD9, TRPV4, TNF, TNFRSF1B, PTGS2, SRF
16	reproductive system phenotype	MP:0005389	7.1	GH1, ALPP, ALPL, IDO1, TNF, TNFSF11
17	tumorigenesis	MP:0002006	6.9	IFNG, TRD@, TRB@, TNF, TNFRSF1B, PTGS2
18	vision/eye phenotype	MP:0005391	6.6	IFNG, HSPG2, TNF, TNFRSF1B, PTGS2, COL2A1
19	normal phenotype	MP:0002873	6.6	CTLA4, SRF, TRB@, TRG@, HMGCR, NLRP3
20	homeostasis/metabolism phenotype	MP:0005376	6.2	B2M, IGF1, IFNB1, F9, F8, IDO1
21	growth/size phenotype	MP:0005378	6.1	NLRP3, HAS2, HGD, HAMP, SLC26A3, DCN
22	mortality/aging	MP:0010768	5.9	KITLG, LMNA, BMP2, BMP7, ANKH, CCL3
23	immune system phenotype	MP:0005387	5.9	LMNA, IFNB1, IFNG, F9, F8, F2
24	behavior/neurological phenotype	MP:0005386	5.9	LTA, PHB2, COL2A1, COMP, SRF, PTGS2
25	cardiovascular system phenotype	MP:0005385	5.6	FGF23, IL10, IL15, IL1B, IL1R1, IL1RN
26	cellular phenotype	MP:0005384	3.2	ALPL, CTLA4, NOD2, PHB2, LTA, ACP1

Articles related to arthropathy:

(show top 50)    (show all 85)

id	Title	Authors	Year	Affiliating Genes
1	A novel deletion mutation in proteoglycan-4 underlies camptodactyly-arthropathy-coxa-vara-pericarditis syndrome in a consanguineous pakistani family. (21565623)	Basit S.... Ahmad W.	2011	PRG4
2	Mutations in TRPV4 cause an inherited arthropathy of hands and feet. (21964574)	LamandAc S.R.... Bateman J.F.	2011	TRPV4
3	A homozygous recurring mutation in WISP3 causing prog ressive pseudorheumatoid arthropathy. (21528827)	Temiz F.... Topaloglu A.K.	2011	WISP3
4	Precocious bilateral hip joint osteoarthritis is a 'form-fruste' of the arthropathy of hereditary haemochromatosis. (19942354)	Carroll G.J.	2010	HFE
5	Effect of anakinra on arthropathy in CINCA/NOMID synd rome. (20230645)	Miyamae T.... Yokokta S.	2010	IL1RAPL2
6	Familial Aicardi-GoutiA"res syndrome due to SAMHD1 mut ations is associated with chronic arthropathy and contractures. (20358604)	Dale R.C.... Crow Y.J.	2010	SAMHD1
7	The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy. (19116938)	Jansen N.W.... Lafeber F.P.	2009	COMP
8	Investigations on possible role of MIF gene polymorphism in progression of chikungunya infection into cases of acute flaccid paralysis and chronic arthropathy. (19417556)	Fulsundar S.R.... Vijayachari P.	2009	MIF
9	Prevention of arthropathy: may it be extrapolated from patients without inhibitors to patients with inhibitors? (19134030)	Hedner U.	2008	F9, F8
10	Characteristics of T-cell large granular lymphocyte proliferations associated with neutropenia and inflammatory arthropathy. (18474096)	Prochorec-Sobieszek M.... Maryniak R.	2008	TRB@, TRD@, TRG@
11	Contribution of anti-cyclic citrullinated peptide antibody and rheumatoid factor to the diagnosis of arthropathy in haemochromatosis. (17456529)	Aigner E.... Datz C.	2007	HFE
12	Cuff tear arthropathy: evidence of functional variation in pyrophosphate metabolism genes. (17563703)	Peach C.A.... Carr A.J.	2007	ALPL, ANKH
13	Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies. (16846531)	Proost P.... Van Damme J.	2006	IL1B, IL8, IFNB1
14	Anti-tumour necrosis factor-alpha therapy for rheumat oid and other inflammatory arthropathies: update on safety in older patients. (17109564)	Ornetti P.... Maillefert J.F.	2006	TNF
15	Crystal-induced arthropathies: recent investigative advances. (16582687)	Ellman M.H.... Becker M.A.	2006	UMOD
16	Evaluation of the efficacy and safety of etoricoxib i n the treatment of hemophilic arthropathy. (16291600)	Tsoukas C.... Melian A.	2006	PTGS2
17	Proliferation, differentiation, and gene expression profile of osteoblast of patient with spondyloepiphyseal dysplasia tarda with progressive arthropathy (16029628)	Zhou H.D.... Liao E.Y.	2005	WISP3
18	HFE mutations in the pathobiology of hemophilic arthropathy. (15802547)	Cruz E.... De Sousa M.	2005	HFE
19	The acromegalic arthropathy. (16323826)	Colao A.... Lombardi G.	2005	GH1
20	Gene symbol: WISP3. Disease: spondyloepihyseal dysplasia tarda with progressive arthropathy. (15300987)	Liao E.Y.... Ni J.D.	2004	WISP3
21	Pathology and molecular pathogenesis of spondyloepiphyseal dysplasia tarda with progressive arthropathy caused by compound CCN6 heterogeneous gene mutations (15631777)	Peng Y.Q.... Fang T.Y.	2004	WISP3
22	Biologicals in treatment of rheumatoid arthritis and other inflammatory arthropathies (12924105)	Sautner J.... Leeb B.F.	2003	IL1R1
23	Concentrations of cartilage oligomeric matrix protein in dogs with naturally developing and experimentally induced arthropathy. (11939326)	Misumi K.... Sakamoto H.	2002	COMP
24	CD69 expression on lymphocytes and interleukin-15 levels in synovial fluids from different inflammatory arthropathies. (11958434)	Ortiz A.M.... Gonzalez-Alvaro I.	2002	IL15, CD69
25	Anti-tissue transglutaminase antibodies in inflammatory and degenerative arthropathies (12563369)	Spadaro A.... Taccari E.	2002	TGM2
26	Celecoxib: a new option in the treatment of arthropathies and familial adenomatous polyposis. (11336575)	Davies N.M.... de Leeuw M.A.	2001	PTGS2, CPOX
27	Arthropathy in hereditary hemochromatosis. (11148720)	von Kempis J.	2001	HFE
28	Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. (10782809)	Yin W.... Nishioka K.	2000	TNF
29	Haemophilic arthropathy resembles degenerative rather than inflammatory joint disease. (10064394)	Roosendaal G.... Bijlsma J.W.	1999	TNF, IL6
30	Overexpression of monocyte-derived cytokines in active psoriasis: a relation to coexistent arthropathy. (10468194)	Nishibu A.... Kaneko F.	1999	IL6, IL1B, IL8
31	CACP, encoding a secreted proteoglycan, is mutated in camptodactyly- arthropathy-coxa vara-pericarditis syndrome. (10545950)	Marcelino J.... Warman M.L.	1999	VTN, PRG4
32	The development of autoimmune inflammatory arthropathy in mice transgenic for the human T cell leukemia virus type-1 env-pX region is not dependent on H-2 haplotypes and modified by the expression levels of Fas antigen. (9862686)	Iwakura Y.... Saijo S.	1998	FAS
33	Suppression of IL-6 biological activities by activin A and implications for inflammatory arthropathies. (9566800)	Yu E.W.... Yu J.	1998	BMP6
34	The camptodactyly-arthropathy-coxa vara-pericarditis syndrome: clinical features and genetic mapping to human chromosome 1. (9550484)	Bahabri S.A.... Warman M.L.	1998	PRG4
35	Antibodies to cytokeratins in inflammatory arthropathies. (9431591)	Borg A.A.	1997	KRT18, CD79A
36	Severe destructive beta 2-microglobulin arthropathy after 28 years of hemodialysis. (9125253)	Appel H.... Braun J.	1997	B2M
37	Carpal-tunnel syndrome with beta 2-microglobulin amyloid deposits and erosive arthropathy of the wrist and spine in a uraemic patient before chronic haemodialysis. (7753473)	Kessler M.... Gaucher A.	1995	B2M
38	Dialysis arthropathy: outcome after renal transplantation. (7653483)	Bardin T.... Kuntz D.	1995	B2M
39	Study of interleukin-2 receptor in schistosomiasis mansoni and its analogous changes in collagen diseases and schistosomal arthropathy. (7665927)	Khalil H.M.... el Baz H.G.	1995	IL2RA
40	Interrelationships between interleukin (IL)-1, IL-6 and IL-8 in synovial fluid of various arthropathies. (8079829)	Bertazzolo N.... Todesco S.	1994	IL6, IL1B, IL8
41	Serum alpha-1-antitrypsin in hemodialysis patients with dialysis arthropathy. (8314633)	Docci D.... Feletti C.	1993	B2M
42	Spondyloepiphyseal dysplasia tarda with progressive arthropathy: 2 siblings affected (1449627)	DA-az-Mares L.... Carnevale A.	1992	SRF
43	Patients with systemic lupus erythematosus and Jaccoud's arthropathy: a clinical subset with an increased C reactive protein response? (1575582)	Spronk P.E.... Kallenberg C.G.	1992	CRP
44	Treatment of psoriatic arthropathy. (1626281)	Goupille P.... Valat J.P.	1992	IFNG
45	Detection of IL-2 at mRNA and protein levels in synovial infiltrates from inflammatory arthropathies using biotinylated oligonucleotide probes in situ. (1747947)	Howell W.M.... Smith J.L.	1991	IL2
46	Deforming arthropathy complicating primary biliary ci rrhosis. (2066957)	Clark M.... Sack K.	1991	SRF
47	Two cases of HTLV-I associated myelopathy (HAM) complicated with SjAPgren's syndrome, T-lymphocyte alveolitis and arthropathy (2242631)	Ijichi T.... Osame M.	1990	HSPG2
48	Destructive beta 2-microglobulin amyloid arthropathy of the cervico-occipital hinge in a hemodialyzed patient. (2183807)	Kessler M.... Gaucher A.	1990	B2M
49	Dialysis arthropathy: a clinical, biochemical, radiol ogical and histological study of 36 patients. (2267282)	Sethi D.... Gower P.E.	1990	B2M
50	Complications of axial arthropathies. (2114600)	Westmark K.D.... Weissman B.N.	1990	B2M

Genes related to arthropathy according to GeneCards:

(show top 50)    (show all 109)

id	Symbol	Description	Score	GeneCards Section Context
1	PRG4	proteoglycan 4	11.1	Publications, Aliases & Descriptions, Summaries
2	MMP2	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)	11.1	Summaries
3	HAS1	hyaluronan synthase 1	11.0	Summaries
4	HAS2	hyaluronan synthase 2	11.0	Summaries
5	WISP3	WNT1 inducible signaling pathway protein 3	11.0	Publications
6	B2M	beta-2-microglobulin	11.0	Publications
7	COMP	cartilage oligomeric matrix protein	11.0	Publications
8	HFE	hemochromatosis	11.0	Publications
9	F9	coagulation factor IX	11.0	Publications
10	F8	coagulation factor VIII, procoagulant component	11.0	Publications
11	IGF1	insulin-like growth factor 1 (somatomedin C)	11.0	Publications
12	HGD	homogentisate 1,2-dioxygenase	11.0	Publications
13	ZMPSTE24	zinc metallopeptidase STE24 homolog (S. cerevisiae)	11.0	Publications
14	SRF	serum response factor (c-fos serum response element-binding transcription factor)	11.0	Publications
15	ANKH	ankylosis, progressive homolog (mouse)	11.0	Publications
16	IVNS1ABP	influenza virus NS1A binding protein	11.0
17	CD69	CD69 molecule	11.0	Publications
18	CHI3L1	chitinase 3-like 1 (cartilage glycoprotein-39)	11.0
19	DCN	decorin	11.0
20	OSM	oncostatin M	11.0
21	NLRP3	NLR family, pyrin domain containing 3	11.0
22	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
23	FGF23	fibroblast growth factor 23	11.0
24	MMP13	matrix metallopeptidase 13 (collagenase 3)	11.0
25	ANPEP	alanyl (membrane) aminopeptidase	11.0
26	VTN	vitronectin	11.0	Publications
27	BPI	bactericidal/permeability-increasing protein	11.0
28	TAC1	tachykinin, precursor 1	11.0
29	S100A9	S100 calcium binding protein A9	11.0
30	COL2A1	collagen, type II, alpha 1	11.0
31	RETN	resistin	11.0
32	IL15	interleukin 15	11.0	Publications
33	NOD2	nucleotide-binding oligomerization domain containing 2	11.0
34	TNFRSF11B	tumor necrosis factor receptor superfamily, member 11b	11.0	Publications
35	BMP7	bone morphogenetic protein 7	11.0
36	CTLA4	cytotoxic T-lymphocyte-associated protein 4	11.0	Publications
37	S100A8	S100 calcium binding protein A8	11.0
38	MMP1	matrix metallopeptidase 1 (interstitial collagenase)	11.0
39	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
40	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0
41	IL1B	interleukin 1, beta	11.0	Publications
42	TNFSF11	tumor necrosis factor (ligand) superfamily, member 11	11.0
43	ALOX5	arachidonate 5-lipoxygenase	11.0
44	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0
45	BMP2	bone morphogenetic protein 2	11.0
46	TF	transferrin	11.0	Publications
47	KITLG	KIT ligand	11.0
48	TIMP1	TIMP metallopeptidase inhibitor 1	11.0
49	IL1RAPL2	interleukin 1 receptor accessory protein-like 2	11.0	Publications
50	TNF	tumor necrosis factor	11.0	Publications

Pathways related to arthropathy according to GeneDecks:

(show top 50)    (show all 131)

id	Pathway	Score	Top Affiliating Genes
1	Cell adhesion_ECM remodeling41	10.3	MMP2, COL2A1, IGF1, IL8, MMP3, MMP13
2	Cell adhesion ECM remodeling10	10.3	MMP2, MMP3, IGF1, VTN, IL8, MMP1
3	RAR-Gamma-RXR-Alpha Degradation36	10.0	BMP2, BMP7, IL15, IL2, CCL3, LTA
4	IL-15 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.9	CCL3, IL2RA, IL2, IL15
5	Glioma Invasiveness36	9.7	BMP6, TIMP1, KITLG, VTN, BMP2, BMP7
6	Graft-versus-host disease20	9.6	IL2, HLA-B, HLA-C
7	ILK Signaling36	9.5	BMP2, BMP7, FGF23, IGF1, HSPG2, PTGS2
8	NFAT Signaling and Lymphocyte Interactions36	9.1	BMP7, BMP6, CCL3, IL4, IL2, IL15
9	Transcription_Role of VDR in regulation of genes involved in osteoporosis41	9.0	IL6, TNFSF11, TNFRSF11B, TNF, IFNG, IGF1
10	PPAR Pathway36	9.0	KITLG, IL2, IL2RA, IL6, BMP2, IGF1
11	Rheumatoid arthritis20	9.0	CTLA4, CCL3, IL8, TNF, IL1B, IL15
12	Pancreatic Adenocarcinoma36	8.8	MMP2, BMP2, BMP6, BMP7, MMP1, MMP13
13	IL-6 Pathway36	8.7	BMP2, BMP6, BMP7, IL10, IL4, IL8
14	Regulation of eIF4 and p70S6K36	8.6	BMP2, FGF23, IL15, IL4, IL6, CCL3
15	Immune response_MIF-mediated glucocorticoid regulation41	8.6	MMP1, MIF, IL2, IL6, IL8, IFNG
16	Immune response MIF-mediated glucocorticoid regulation10	8.6	PTGS2, TNF, MMP1, MIF, IL2, IL6
17	JNK Pathway36	8.5	KITLG, BMP6, BMP7, IL1R1, IL2, IL2RA
18	NF-KappaB (p50-p65) Pathway36	8.5	GH1, IL6, TIMP1, BMP7, LTA, TNFRSF1B
19	Apoptotic Pathways in Synovial Fibroblasts36	8.5	TIMP1, KITLG, BMP7, LTA, TNFRSF1B, TNF
20	NF-KappaB Family Pathway36	8.5	TIMP1, KITLG, BMP2, BMP6, BMP7, FGF23
21	Molecular Mechanisms of Cancer36	8.4	LTA, TIMP1, OSM, PRG4, COL2A1, TNFSF11
22	DHA Signaling36	8.4	IL2RA, IL6, IGF1, GH1, TIMP1, IL1B
23	PGC1Alpha Pathway36	8.4	IL8, IL4R, IL4, IL2, IL1R1, IL1B
24	Akt Signaling36	8.1	FGF23, CXCL10, OSM, LTA, IL10, IL15
25	Endothelin-1 Signaling Pathway36	8.1	IL4, IL6, CCL3, TNFSF11, OSM, IL2
26	Type I diabetes mellitus20	8.1	IL2, IFNG, HLA-B, HLA-C, TNF, LTA
27	MAPK Signaling36	7.9	KITLG, TNF, IL6, PRG4, OSM, TIMP1
28	Phospholipase-C Pathway36	7.9	BMP6, PRG4, TGM2, COL2A1, GH1, HSPG2
29	p70S6K Signaling36	7.8	GH1, F2, IL6, IL4R, IGF1, IL4
30	Chagas disease (American trypanosomiasis)20	7.8	IFNG, CCL3, IL10, IL1B, IL6, FAS
31	SOCS Pathway36	7.8	IL15, BMP6, BMP7, FGF23, IL4, IL10
32	THC Differentiation Pathway36	7.8	IL10, TNFRSF1B, TNF, IL4, IFNG, IL4R
33	ERK Signaling36	7.7	IL2, CXCL10, PRG4, IL4, IL6, CCL3
34	PEDF Induced Signaling36	7.7	SRF, LTA, OSM, CXCL10, TNFSF11, TNF
35	all-trans-Retinoic Acid Signaling in Brain36	7.6	BMP2, BMP6, BMP7, IL10, IL15, IL1B
36	Cytokine Network36	7.5	LTA, TNF, IFNG, IFNB1, IL8, IL6
37	MIF Regulation of Innate Immune Cells36	7.4	MIF, IL2, IL4, BMP2, BMP6, BMP7
38	MIF Mediated Glucocorticoid Regulation36	7.4	BMP2, BMP6, TNF, TNFSF11, PTGS2, LTA
39	Rho Family GTPases36	7.3	KITLG, GH1, TNFSF11, COL2A1, LTA, TIMP1
40	Allograft rejection20	7.3	HLA-C, FAS, IL4, TNF, IL10, IFNG
41	Glucocorticoid Receptor Signaling36	7.2	IL10, IL6, IL4R, TNFRSF1B, BMP2, BMP6
42	PAK Pathway36	7.1	CXCL10, IL4, IL6, IL8, CCL3, IGF1
43	Tec Kinases Signaling36	7.1	IL6, IL4R, IL4, IL2RA, IL2, IL15
44	STAT3 Pathway36	7.0	BMP2, BMP6, BMP7, IL10, IL15, OSM
45	TGF-Beta Pathway36	6.9	IL4, IL2RA, IL2, IL1R1, IL1B, IL15
46	MAPK Family Pathway36	6.7	BMP2, CCL3, IGF1, GH1, TNF, TNFRSF1B
47	p38 Signaling36	6.6	IL2RA, IL4, IL4R, IL6, IL8, CCL3
48	Antioxidant Action of Vitamin-C36	6.6	IL15, IL1B, IL1R1, IL2, IL2RA, IL4
49	Cytokine-cytokine receptor interaction20	5.7	CXCL10, OSM, LTA, IL4, IL2RA, IL2
50	JAK-STAT Pathway36	5.5	IL6, IL8, CCL3, IGF1, IFNB1, IFNG

Compounds related to arthropathy according to GeneDecks:

(show top 50)    (show all 411)

id	Compound	Score	Top Affiliating Genes
1	cyclophosphamide32 34 9 9	13.7	F9, F8, TRB@, TAC1
2	glycosaminoglycan32	10.5	VTN, BMP2, MMP13, IL1RAPL2, SRF, COMP
3	latex32	9.6	KITLG, VTN, FTH1, IL1RN, CCL3, F9
4	alginate32	9.6	BMP2, BMP7, BGLAP, CD79A, MMP13, MMP2
5	hyaluronic acid32 18	10.5	VTN, BMP6, CHI3L1, B2M, MMP1, MMP13
6	endotoxin32	9.5	RETN, BPI, CIITA, S100A8, S100A9, MIF
7	n acetylcysteine32	9.5	CD79A, MMP1, MMP2, MMP3, IL1R1, IL2RA
8	curcumin32	9.4	VTN, MMP1, MMP13, MMP2, MMP3, MIF
9	alendronate32 9 9	11.3	BMP2, BGLAP, MMP1, MMP13, MMP2, MMP3
10	prostaglandin32	9.2	KITLG, MMP1, MMP13, MMP3, IL1B, IL1R1
11	gp 13032	9.1	BMP6, IL15, IL1R1, IL2RA, IL4R, FAS
12	iron32 18	10.1	KITLG, B2M, FTH1, FTL, MMP3, IL1R1
13	procollagen32	9.0	BMP2, BMP6, ZMPSTE24, BGLAP, MMP1, MMP13
14	rituximab32 34 9 9	11.8	CD79A, IL10, IL15, IL1R1, IL2, IL2RA
15	epinephrine32 9 18 9	11.7	KITLG, VTN, BMP6, CD79A, CD69, MMP1
16	aspartate32	8.7	RETN, VTN, BMP6, B2M, MMP2, ANPEP
17	estrogen32	8.7	RETN, BMP2, BMP7, BGLAP, CHI3L1, MMP1
18	cysteine32	8.6	VTN, BPI, BGLAP, UMOD, S100A8, CD79A
19	ly29400232	8.6	RETN, VTN, CD69, MMP2, IL10, IL1B
20	ascorbic acid32 18	9.5	BMP2, BMP7, BGLAP, FTH1, MMP13, MMP2
21	h2o232	8.4	KITLG, BGLAP, S100A9, FTH1, FTL, CD79A
22	lipoteichoic acid32	8.2	BPI, IL10, IL1B, IL1R1, IL1RN, IL6
23	aspirin32 34 18	10.1	KITLG, VTN, BMP6, CD79A, MMP1, MMP2
24	thyroxine32 18	9.0	RETN, BGLAP, CIITA, B2M, CD79A, IL10
25	azathioprine32 34 9 9	11.0	BMP2, BGLAP, CD79A, MMP2, IL10, IL2
26	poly(i-c)32	7.9	CD69, IL15, IL1B, IL4, IL6, IL8
27	tgf beta132	7.9	KITLG, BMP6, BMP7, MMP1, MMP13, MMP2
28	norepinephrine32 9 18 9	10.9	RETN, KITLG, BMP6, CD79A, MMP1, MMP2
29	vegf32	7.8	RETN, KITLG, VTN, BPI, BMP2, BMP7
30	cholesterol32 9 18 9	10.8	RETN, KITLG, VTN, BPI, LMNA, BMP2
31	histamine32 18	8.7	KITLG, BMP6, BGLAP, S100A8, CD79A, IL15
32	pd 98,05932	7.6	KITLG, VTN, BMP2, BMP6, CD69, MMP1
33	calcium32 9 18 9	10.6	RETN, KITLG, VTN, LMNA, BMP2, BMP7
34	lipid32	7.5	RETN, KITLG, VTN, BPI, LMNA, BMP2
35	ibuprofen32 9 18 9	10.5	BMP6, MMP1, MMP2, MMP3, IL10, IL1B
36	chloroquine32 34 9 9	10.3	VTN, BMP6, CIITA, B2M, FTL, CD79A
37	methotrexate32 34 42 9 9	11.1	KITLG, BMP6, S100A8, S100A9, CD79A, CD69
38	creatinine32	6.9	RETN, KITLG, BPI, LMNA, BMP2, BMP6
39	polyinosinic-polycytidylic acid32	6.7	CIITA, IL10, IL15, IL2, IL4, IL6
40	paraffin32	6.6	KITLG, BGLAP, S100A8, B2M, CD79A, MMP1
41	tacrolimus32 34 9 9	9.6	VTN, BMP2, BMP6, CD79A, CD69, IL10
42	lactate32	6.4	KITLG, VTN, BPI, BMP2, BMP6, B2M
43	alanine32	6.1	RETN, KITLG, VTN, BPI, LMNA, BMP2
44	actinomycin d32	6.1	RETN, KITLG, BPI, BMP2, CIITA, CD69
45	neopterin32	6.0	B2M, CD79A, IL10, IL1B, IL1R1, IL1RAPL2
46	rantes32	5.4	KITLG, BMP6, CIITA, MMP1, MMP13, MMP3
47	prednisolone32 9 9	7.3	KITLG, BMP6, BGLAP, CD79A, MMP1, MMP13
48	indomethacin32 9 9	7.3	BMP2, BMP6, B2M, CD79A, MMP1, MMP13
49	retinoic acid32 42 18	6.6	KITLG, VTN, BPI, LMNA, BMP2, BMP6
50	dexamethasone32 42 34 9 9	6.1	RETN, KITLG, VTN, BMP2, BMP6, BMP7

Cellular components related to arthropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	proteinaceous extracellular matrix	GO:005578	10.1	ACAN, COMP, TNFRSF11B, MMP3, MMP2, MMP13
2	MHC class I protein complex	GO:042612	9.8	HFE, HLA-C, HLA-B, MICA, B2M
3	integral to plasma membrane	GO:005887	9.3	HLA-C, TNF, TNFSF11, CTLA4, HFE, TFR2
4	Golgi lumen	GO:005796	9.2	DCN, ACAN, HSPG2, F2, F7, F9
5	external side of plasma membrane	GO:009897	8.5	IFNG, TNF, CTLA4, CXCL10, ANPEP, FAS
6	extracellular region	GO:005576	4.8	RETN, IL15, IL1B, IL1R1, IL2, IL4R
7	extracellular space	GO:005615	4.1	WISP3, KITLG, MMP2, MMP3, MICA, MIF

Biological processes related to arthropathy according to GeneDecks:

(show top 50)    (show all 60)

id	Name	GO ID	Score	Top Affiliating Genes
1	chronic inflammatory response to antigenic stimulus	GO:002439	10.8	IL1RN, IL1B
2	extracellular matrix disassembly	GO:022617	10.7	TIMP1, MMP3, MMP2, MMP13, MMP1
3	positive regulation of heterotypic cell-cell adhesion	GO:034116	10.7	TNF, IL1B, BMP7
4	hyaluronan biosynthetic process	GO:030213	10.7	HAS2, HAS1, IL1B
5	collagen catabolic process	GO:030574	10.7	MMP3, MMP2, MMP13, MMP1
6	extracellular matrix organization	GO:030198	10.6	TIMP1, COL2A1, TNFRSF11B, TNF, MMP3, MMP2
7	iron ion transport	GO:006826	10.6	TFR2, HFE, FTL, FTH1
8	cellular iron ion homeostasis	GO:006879	10.5	HAMP, TFR2, TF, HFE, FTL, FTH1
9	response to vitamin D	GO:033280	10.5	CXCL10, PTGS2, ALPL, IL1B, BGLAP
10	cellular response to organic cyclic compound	GO:071407	10.5	TNF, ALPL, CCL3, IL1B, BMP2
11	positive regulation of fever generation	GO:031622	10.4	IL1B, TNF, PTGS2
12	response to mechanical stimulus	GO:009612	10.4	DCN, TNF, TRPV4, CHI3L1, BGLAP, BMP2
13	positive regulation of ERK1 and ERK2 cascade	GO:070374	10.4	NOD2, TNF, CCL3, IL1B, FGF23, MIF
14	positive regulation of protein kinase B signaling cascade	GO:051897	10.4	TNFSF11, TNF, F7, IGF1, CCL3, CHI3L1
15	negative regulation of lipid storage	GO:010888	10.3	CRP, TNF, IL6
16	positive regulation of smooth muscle cell proliferation	GO:048661	10.2	TGM2, PTGS2, TNF, IGF1, IL6
17	aging	GO:007568	10.1	DCN, TIMP1, HMGCR, FAS, IL1B, IL15
18	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	10.1	OSM, GH1, IGF1, IL6, MIF, VTN
19	acute-phase response	GO:006953	10.0	CRP, F2, F8, IL6, IL1RN
20	cartilage development	GO:051216	10.0	COL2A1, CHI3L1, BMP7, BMP6, BMP2
21	response to lipopolysaccharide	GO:032496	10.0	CXCL10, DCN, TAC1, LTA, PTGS2, ALPL
22	positive regulation of calcidiol 1-monooxygenase activity	GO:060559	9.9	TNF, IFNG, IL1B
23	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.9	NLRP3, NOD2, TNFSF11, TNF, IL6, IL1B
24	positive regulation of acute inflammatory response	GO:002675	9.8	IL6, TAC1, OSM
25	positive regulation of osteoblast differentiation	GO:045669	9.8	IGF1, IL6, BMP7, BMP6, BMP2
26	positive regulation of membrane protein ectodomain proteolysis	GO:051044	9.8	TNFRSF1B, TNF, IFNG, IL1B
27	skeletal system development	GO:001501	9.7	TRAPPC2, TNFRSF11B, COMP, COL2A1, ACAN, ALPL
28	positive regulation of interleukin-1 beta secretion	GO:050718	9.7	CCL3, IFNG, NOD2, NLRP3
29	response to hypoxia	GO:001666	9.7	CRP, SRF, TNF, FAS, IL1B, BMP2
30	negative regulation of cell proliferation	GO:008285	9.7	OSM, SRF, PTGS2, TNF, IFNB1, IGF1
31	proteolysis	GO:006508	9.6	TFR2, ACAN, F2, F7, F9, ANPEP
32	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	9.5	GH1, IGF1, IL4, IL2
33	positive regulation of chemokine biosynthetic process	GO:045080	9.5	TNF, IFNG, IL4, IL1B
34	defense response to virus	GO:051607	9.4	CXCL10, NLRP3, IFNG, IFNB1, IL6, MICA
35	positive regulation of sequence-specific DNA binding transcription factor activity	GO:051091	9.4	SRF, TNFSF11, TNF, IL6, IL4, IL1B
36	cell-cell signaling	GO:007267	9.3	WISP3, CXCL10, TAC1, LTA, CCL3, IL2
37	humoral immune response	GO:006959	9.3	LTA, TNF, IFNG, IFNB1, IL6
38	negative regulation of growth of symbiont in host	GO:044130	9.2	LTA, TNF, IFNG, IL10
39	positive regulation of T cell proliferation	GO:042102	9.1	IFNG, IL6, IL4, IL1B, IL15
40	response to glucocorticoid stimulus	GO:051384	9.1	PTGS2, TNF, ALPL, FAS, IL6, IL1RN
41	defense response to bacterium	GO:042742	9.0	HAMP, NOD2, IFNG, IFNB1, IL10, MICA
42	anti-apoptosis	GO:006916	9.0	SYVN1, COMP, TNF, F7, IGF1, FAS
43	positive regulation of isotype switching to IgG isotypes	GO:048304	8.9	IFNG, IL4, IL2
44	positive regulation of MHC class II biosynthetic process	GO:045348	8.9	IFNG, IL4, IL10, CIITA
45	cytokine-mediated signaling pathway	GO:019221	8.8	TNFSF11, HLA-C, HLA-B, IFNG, IFNB1, IL6
46	cell surface receptor signaling pathway	GO:007166	8.6	CXCL10, F2, IFNG, IFNB1, IL2RA, IL1R1
47	inflammatory response	GO:006954	8.4	CXCL10, IL10, MIF, S100A9, S100A8, CHI3L1
48	response to drug	GO:042493	8.0	LTA, PTGS2, TNFRSF11B, TNF, IFNG, FAS
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	7.7	IFNG, HOXD9, TNF, TNFSF11, SRF, OSM
50	immune response	GO:006955	7.5	HAMP, CXCL10, PRG4, IL1RN, IL1R1, IL15

Molecular functions related to arthropathy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	alkaline phosphatase activity	GO:004035	9.7	ALPPL2, ALPP, ALPL, CILP
2	growth factor activity	GO:008083	7.1	IL6, IGF1, F2, GH1, OSM, WISP3
3	cytokine activity	GO:005125	6.4	KITLG, OSM, LTA, TNFSF11, TNFRSF11B, TNF
4	protein binding	GO:005515	5.9	NOD2, CRP, CTLA4, SRF, TNFRSF1B, TNF