MCID: ART023
MIFTS: 63

Arthropathy malady

Bone diseases category

Summaries for Arthropathy

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Wikipedia:66 An arthropathy is a disease of a joint. more...

MalaCards: Arthropathy, also known as joint ankylosis of the pelvic region and thigh, is related to arthritis and hemochromatosis. An important gene associated with Arthropathy is PRG4 (proteoglycan 4), and among its related pathways are Osteoclast Signaling and Osteoblast Signaling. The compounds pentosidine and hcc-1 have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and t cells, and related mouse phenotypes are limbs/digits/tail and skeleton.

Disease Ontology:9 A bone inflammation disease that is located in joint.

Aliases & Classifications for Arthropathy

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9Disease Ontology, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 28ICD9CM, 41NCIt, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Bone diseases


Aliases & Descriptions:

arthropathy 9 11 46 63
joint ankylosis of the pelvic region and thigh 9
ankylosis of joint of pelvic region and thigh 9
joint ankylosis of the ankle and/or foot 9
ankylosis of joint of ankle and/or foot 9
joint ankylosis of the shoulder region 9
joint ankylosis of the ankle and foot 9
ankylosis of joint of shoulder region 9
arthropathy associated with infection 63
ankylosis of joint of multiple sites 9
ankylosis of ankle and foot joint 9
joint ankylosis of the lower leg 9
joint ankylosis of the upper arm 9
ankylosis of joint of lower leg 9
ankylosis of joint of upper arm 9
joint ankylosis of the forearm 9
ankylosis of joint of forearm 9
ankylosis of lower leg joint 9
ankylosis of multiple joints 9
ankylosis of upper arm joint 9
joint ankylosis of the hand 9
ankylosis of joint of hand 9
ankylosis of forearm joint 9
ankylosis of hand joint 9
infectious arthropathy 9


Related Diseases for Arthropathy

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Arthropathy family:

Transient Arthropathy

Diseases related to Arthropathy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 241)
idRelated DiseaseScoreTop Affiliating Genes
1arthritis30.5HFE, COMP, MMP2, TNFSF11, WISP3, B2M
2hemochromatosis30.5HFE, B2M
3rheumatoid arthritis30.4B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
4multiple myeloma30.2TNFRSF11B, TNFSF11, B2M
5myeloma30.2B2M, TNFSF11, TNFRSF11B
6osteoarthritis30.2HFE, TNFRSF11B, COMP, PRG4, MMP2, TNFSF11
7psoriatic arthritis30.1TNFSF11, COMP, TNFRSF11B
8amyloidosis30.1B2M, F9
9ankylosing spondylitis30.1TNFSF11, TNFRSF11B
10synovitis30.0TNFRSF11B, COMP, B2M, TNFSF11, PRG4
11aneurysm30.0MMP2, TNFRSF11B
12gingivitis29.7TNFRSF11B, TNFSF11
13primary hyperoxaluria29.6TNFSF11, HFE, TNFRSF11B, B2M
14hemophilic arthropathy10.9
15camptodactyly arthropathy coxa vara pericarditis syndrome10.6
16progressive pseudorheumatoid arthropathy of childhood10.5
17neurogenic arthropathy10.5
18torg winchester syndrome10.4
19lupus erythematosus10.4
20pericarditis10.4
21reactive arthritis10.4
22systemic lupus erythematosus10.4
23syringomyelia10.4
24behcet's syndrome arthropathy10.4
25pseudogout10.4
26transient arthropathy10.3
27enthesopathy10.3
28gout10.3
29ochronosis10.3
30neuropathy10.3
31cervicitis10.2
32psoriasis10.2
33hemophilia10.2
34acromegaly10.2
35diabetes mellitus10.2
36osteoporosis10.2
37distal arthrogryposis10.2
38alkaptonuria10.2
39juvenile rheumatoid arthritis10.2
40hepatitis10.2
41inflammatory bowel disease10.2
42digital arthropathy-brachydactyly, familial10.2
43atlantoaxial subluxation10.2
44leukemia10.1
45vasculitis10.1
46chondrocalcinosis 210.1
47periapical granuloma10.1TNFSF11
48ankylosis10.1
49hepatitis c10.1
50hidradenitis suppurativa10.1

Graphical network of the top 20 diseases related to Arthropathy:



Diseases related to arthropathy

Symptoms for Arthropathy

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Drugs & Therapeutics for Arthropathy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Arthropathy

Drug clinical trials:

Search ClinicalTrials for Arthropathy

Search NIH Clinical Center for Arthropathy

Search CenterWatch for Arthropathy

Genetic Tests for Arthropathy

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Anatomical Context for Arthropathy

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Sources:
34MalaCards, 15FMA
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MalaCards organs/tissues related to Arthropathy:

34
Bone, T cells, Heart, Spinal cord, Lung, Liver, Skin, Bone marrow, Monocytes, Cervix, Testes, Uterus, Ovary, Pituitary, Eye

FMA organs/tissues related to Arthropathy:

15
Joint

Animal Models for Arthropathy or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Arthropathy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053718.0TNFSF11, TNFRSF11B, PRG4, COMP, HFE
2MP:00053907.9TNFSF11, TNFRSF11B, MMP2, PRG4, COMP
3MP:00053767.8TRPV4, HFE, MMP2, TNFSF11, B2M, F9
4MP:00053857.7F9, B2M, TNFRSF11B, MMP2, PRG4, TRPV4
5MP:00053977.3F9, B2M, TNFSF11, TNFRSF11B, MMP2, HFE
6MP:00053787.1B2M, TNFSF11, TNFRSF11B, MMP2, COMP, HFE
7MP:00107687.1F9, B2M, TNFSF11, TNFRSF11B, MMP2, PRG4
8MP:00053877.0HFE, COMP, MMP2, TNFRSF11B, TNFSF11, B2M

Publications for Arthropathy

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Sources:
53PubMed
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Articles related to Arthropathy:

(show top 50)    (show all 764)
idTitleAuthorsYear
1
Progression of haemophilic arthropathy in children: a Lithuanian--Danish comparative study. (23167920)
2013
2
Primary knee arthrodesis for severe crystalline arthropathy. (24278911)
2013
3
Risk factors for dislocation arthropathy after Latarjet procedure: a long-term study. (23508865)
2013
4
Acute charcot arthropathy of the wrist in a diabetic patient. (22961091)
2013
5
Jaccoud's arthropathy. (23290493)
2013
6
Bilateral neuro-arthropathy of the ankle as a sequela of undiagnosed tabes dorsalis. (23623735)
2013
7
Rapidly destructive arthropathy of the hip joint in patients with rheumatoid arthritis. (22691675)
2012
8
Occult erosions in Jaccoud arthropathy. (22832301)
2012
9
Atypical case of hypertrophic osteo-arthropathy. (23029954)
2012
10
Reverse total shoulder arthroplasty for cuff tear arthropathy: the clinical effect of deltoid lengthening and center of rotation medialization. (22056324)
2012
11
Joint distraction results in clinical and structural improvement of haemophilic ankle arthropathy: a series of three cases. (22530605)
2012
12
Visualization of amyloid arthropathy in light-chain systemic amyloidosis on F-18 FDG PET/CT scan. (21157212)
2011
13
Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis. (21131647)
2011
14
Usefulness of wireless capsule endoscopy for detecting inflammatory bowel disease in children presenting with arthropathy. (21643650)
2011
15
Ultrasound detects joint damage and bleeding in haemophilic arthropathy: a proposal of a score. (21070482)
2011
16
Charcot arthropathy of the knee. A case-based review. (21057837)
2011
17
Bypassing agent prophylaxis for preventing arthropathy in patients with inhibitors. (19702885)
2010
18
Midtarsal arthrodesis in the treatment of Charcot midfoot arthropathy. (19122082)
2009
19
Use of platelet-rich concentrate and bone marrow aspirate in high-risk patients with Charcot arthropathy of the foot. (19254506)
2009
20
Acute gouty arthropathy mimicking infection after total knee arthroplasty. (19627909)
2009
21
Refinement of a sonographic protocol for assessment of haemophilic arthropathy. (19493019)
2009
22
The outcome of cementless total hip arthroplasty in haemophilic hip arthropathy. (19444974)
2009
23
Complications in the management of Charcot spinal arthropathy. (19769521)
2009
24
Haemophilic arthropathy from A to Z. Introduction. (18494685)
2008
25
Haemophilic arthropathy: the importance of the earliest haemarthroses and consequences for treatment. (19134026)
2008
26
Magnetic resonance imaging in early stage charcot arthropathy: correlation of imaging findings and clinical symptoms. (18948232)
2008
27
Charcot arthropathy risk elevation in the obese diabetic population. (18954849)
2008
28
Orthopaedic management of haemophilia arthropathy of the ankle. (18510538)
2008
29
The role of chicken IL-1beta, IL-6 and TNF-alpha in the occurrence of amyloid arthropathy. (18612836)
2008
30
Sonography for assessment of haemophilic arthropathy in children: a systematic protocol. (17498079)
2007
31
Rotator cuff tear arthropathy. (17548883)
2007
32
Gouty arthropathy of the cervical spine in a young adult. (17475601)
2007
33
Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women. (16551465)
2006
34
Calcium pyrophosphate dihydrate-crystal induced arthropathy]. (14991274)
2004
35
Periarticular aneurysm following total knee replacement in hemophilic arthropathy. A case report. (14668517)
2003
36
Synovial hyperplasia in HTLV-I associated arthropathy is induced by tumor necrosis factor-alpha produced by HTLV-I infected CD68+ cells. (10782809)
2000
37
Hemophilic arthropathy: evaluation of clinical and radiological characteristics and disability. (11105618)
2000
38
Synoviorthesis with colloidal 32P chromic phosphate for the treatment of hemophilic arthropathy. (8150815)
1994
39
The arthropathy of the Muckle-Wells syndrome. (8000753)
1994
40
Synovectomy of the ankle for hemophilic arthropathy. (8200887)
1994
41
Levels of synovial fluid interleukin-1 receptor antagonist in rheumatoid arthritis and other arthropathies. Potential contribution from synovial fluid neutrophils. (8507219)
1993
42
Ultrasound in the diagnosis of the early stages of hemophilic arthropathy of the knee. (1632211)
1992
43
Radiographic and therapeutic aspects of neurogenic arthropathy. (1297567)
1992
44
Resorptive arthropathy and rib erosions in mixed connective tissue disease. (2359089)
1990
45
Arthropathy in von Willebrand's disease. (2787227)
1989
46
Idiopathic neurogenic arthropathy. (4044822)
1985
47
Hemophilic arthropathy complicated by polyarticular septic arthritis. (6421050)
1984
48
Neurogenic arthropathy and recurring fractures with subclinical inherited neuropathy. (6681882)
1983
49
Hemophilic arthropathy. (6048906)
1967
50
Hemophilic arthropathy. (13775889)
1960

Variations for Arthropathy

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Expression for genes affiliated with Arthropathy

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthropathy

Search GEO for disease gene expression data for Arthropathy.

Pathways for genes affiliated with Arthropathy

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Sources:
51PathCards, 39NCBI BioSystems Database, 61Thomson Reuters, 58SinoBiological, 55R&D Systems
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Compounds for genes affiliated with Arthropathy

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Sources:
46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR, 3BitterDB
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Compounds related to Arthropathy according to GeneCards/GeneDecks:

(show top 50)    (show all 86)
idCompoundScoreTop Affiliating Genes
1pentosidine469.7B2M, COMP
2hcc-1469.5TNFSF11, TNFRSF11B
3denosumab46 1210.5TNFRSF11B, TNFSF11
4teriparatide46 1210.4TNFSF11, TNFRSF11B
5polyethylene469.4TNFSF11, TNFRSF11B
6hyaluronic acid46 2510.3B2M, COMP, PRG4, MMP2
7ibandronate46 1210.3TNFRSF11B, TNFSF11
8latex469.3PRG4, TNFSF11, F9
9zoledronic acid469.2TNFRSF11B, TNFSF11, MMP2
10alendronate46 52 1211.2TNFSF11, TNFRSF11B, MMP2
11ns 39846 6210.2MMP2, TNFRSF11B, TNFSF11
123-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide469.2MMP2, TNFRSF11B, TNFSF11
13hydroxyapatite469.2TNFRSF11B, PRG4, TNFSF11
14alginate469.2COMP, F9, MMP2, PRG4
15pamidronate46 52 1211.2TNFSF11, B2M, TNFRSF11B
16celecoxib46 62 30 52 25 1214.2MMP2, TNFRSF11B, TNFSF11
17pmma469.1TNFSF11, TNFRSF11B, B2M
1825-hydroxyvitamin d469.1TNFSF11, TNFRSF11B, B2M
19phosphorus469.1TNFSF11, B2M, TNFRSF11B
20azathioprine46 3 52 1212.1MMP2, TNFRSF11B, TNFSF11
21deoxypyridinoline469.0COMP, TNFRSF11B, TNFSF11
22etanercept46 52 1211.0COMP, TNFRSF11B, TNFSF11
23infliximab46 52 1211.0COMP, TNFSF11, TNFRSF11B
24p003468.9TNFRSF11B, HFE, COMP
25tgf beta1468.9TNFRSF11B, MMP2, COMP
26hydrocortisone46 3 62 1211.9TNFRSF11B, MMP2, F9
27vitamin k2468.8TNFRSF11B, TNFSF11
28ascorbic acid46 259.7TNFSF11, HFE, MMP2, TNFRSF11B
29procollagen468.7MMP2, TNFRSF11B, TNFSF11, COMP
30heparan sulfate46 259.7B2M, TNFRSF11B, TNFSF11
31genistein46 30 62 3 25 1213.7TNFSF11, MMP2, TNFRSF11B, B2M
32methotrexate52 46 1210.7TNFSF11, TNFRSF11B, MMP2, COMP
33pge2468.7TNFSF11, B2M, TNFRSF11B, MMP2
34alanine468.6B2M, TRPV4, MMP2, F9, HFE
35prednisolone46 30 1210.6MMP2, COMP, F9, TNFRSF11B
36vitamin d468.6TNFSF11, TNFRSF11B, COMP, B2M
37urea46 25 1210.5TNFRSF11B, B2M, F9, TNFSF11
38sodium46 259.5TRPV4, TNFSF11, B2M, TNFRSF11B
39vegf468.4MMP2, TNFRSF11B, WISP3, B2M, TNFSF11
40cyclosporin a46 30 6210.4TNFRSF11B, TNFSF11, B2M, F9
41cycloheximide468.4B2M, TNFSF11, TNFRSF11B, MMP2
42glucose467.9B2M, F9, TNFRSF11B, HFE, COMP
43aspartate467.8HFE, COMP, F9, B2M, MMP2, TNFRSF11B
44testosterone46 62 25 1210.8B2M, TNFSF11, F9, TNFRSF11B, MMP2, HFE
45estrogen467.8B2M, F9, TNFSF11, TNFRSF11B, MMP2, HFE
46creatinine467.7MMP2, F9, COMP, TNFRSF11B, TNFSF11, B2M
47tyrosine467.7TNFRSF11B, TRPV4, MMP2, TNFSF11, F9, HFE
48lipid467.4HFE, F9, TNFSF11, TNFRSF11B, COMP
49calcium46 52 25 1210.3COMP, MMP2, TNFRSF11B, TNFSF11, F9, B2M
50cysteine466.9HFE, F9, WISP3, TNFSF11, MMP2, B2M

GO Terms for genes affiliated with Arthropathy

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17Gene Ontology
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Cellular components related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MHC class I protein complexGO:0426129.3HFE, B2M
2proteinaceous extracellular matrixGO:0055788.8COMP, MMP2, TNFRSF11B
3extracellular spaceGO:0056157.2COMP, B2M, WISP3, TNFSF11, TNFRSF11B, MMP2
4extracellular regionGO:0055767.2COMP, TNFSF11, MMP2, F9, B2M, TNFRSF11B

Biological processes related to Arthropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell mediated cytotoxicityGO:0019169.5HFE, B2M
2immune responseGO:0069559.2HFE, PRG4, TNFSF11
3extracellular matrix organizationGO:0301988.5COMP, MMP2, TNFRSF11B

Products for genes affiliated with Arthropathy

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Sources for Arthropathy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet