MCID: ART006
MIFTS: 42

Arthus Reaction malady

Summaries for Arthus Reaction

About this section


Wikipedia:63 In immunology, the Arthus reaction (/??r?tu?s/, /??r?tju?s/) is a type of local type III... more...

MalaCards based summary: Arthus Reaction, also known as arthus type urticaria, is related to vasculitis and arthritis. An important gene associated with Arthus Reaction is SELL (selectin L), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Complement Pathway. The compounds bromelain and boswellic acids have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and testes, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Arthus Reaction

About this section
Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 27ICD9CM, 38NCIt, 55SNOMED-CT, 33MeSH
See all sources

Arthus Reaction, Aliases & Descriptions:

Name: Arthus Reaction 9 43 60
Arthus Type Urticaria 9
 
Arthus Phenomenon 9


External Ids:

Disease Ontology9 DOID:1556
ICD9CM27 995.21
SNOMED-CT55 29548007, 402413008
NCIt38 C34400
MeSH33 D001183

Related Diseases for Arthus Reaction

About this section

Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 87)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.6CD46, ELANE, SELL, TNF
2arthritis30.6SELL, TNF
3peritonitis30.0CR1, ALOX5, CXCL2, TNF
4glomerulonephritis29.7ELANE, MIF, ALOX5, CR1, CD46
5asthma29.1TNF, SELL, ELANE, MIF, ALOX5, CR1
6pneumonia29.0TNF, SELL, CXCL2, ELANE, CR1, HMOX1
7cryptococcosis10.5SELL
8conjunctivitis10.4HRH1
9bronchopulmonary dysplasia10.4SELL, ELANE
10extrinsic allergic alveolitis10.3ELANE, SELL
11kawasaki disease10.3ELANE, SELL
12hepatitis10.3
13hepatitis b10.3
14thrombocytopenia10.3
15keratitis10.3MIF, CXCL2
16chorioamnionitis10.3TNF, ELANE
17respiratory failure10.3ALOX5, ELANE
18pulmonary sarcoidosis10.2SELL, TNF
19behcet's disease10.2TNF, SELL
20pulmonary emphysema10.2HMOX1, ELANE
21allergic rhinitis10.2HRH1, ALOX5
22periodontal disease10.2ELANE, TNF
23angioedema10.2ALOX5, HRH1
24aneurysm10.2ALOX5, ELANE, SELL
25periodontitis10.2ELANE, TNF
26graft-versus-host disease, protection against10.2SELL, TNF
27non-suppurative otitis media10.2SELL, ALOX5
28gastritis10.2CXCL2, MIF, CD46
29sickle cell disease10.2HMOX1, SELL
30diphtheria10.2
31shwartzman phenomenon10.2
32encephalitis10.2
33eosinophilia10.2
34pertussis10.2
35pleurisy10.2
36thyroiditis10.2
37urticaria10.1HRH1, ALOX5
38afibrinogenemia10.1CD46, CR1
39bacterial meningitis10.1CXCL2, CR1
40acute respiratory distress syndrome10.1TNF, ELANE, ALOX5
41cork-handlers' disease10.1HMOX1, ELANE
42allergic asthma10.1HRH1, ALOX5, SELL
43vascular disease10.1CD46, HMOX1, ELANE
44skin disease10.0TNF, SELL, HRH1
45pulmonary fibrosis10.0HMOX1, ALOX5, ELANE
46arthropathy10.0ALOX5, TNF
47diabetes mellitus, noninsulin-dependent10.0TNF, SELL, MIF
48psoriasis10.0ALOX5, ELANE, TNF
49systemic scleroderma10.0CD46, ALOX5, MIF, SELL
50osteoarthritis10.0TNF, CXCL2, ALOX5

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to arthus reaction

Symptoms for Arthus Reaction

About this section

Drugs & Therapeutics for Arthus Reaction

About this section

Drug clinical trials:

Search ClinicalTrials for Arthus Reaction

Search NIH Clinical Center for Arthus Reaction

Genetic Tests for Arthus Reaction

About this section

Anatomical Context for Arthus Reaction

About this section

MalaCards organs/tissues related to Arthus Reaction:

31
Skin, Neutrophil, Testes, Skeletal muscle, Lung, Eye, Thyroid, B cells, Tongue

Animal Models for Arthus Reaction or affiliated genes

About this section

MGI Mouse Phenotypes related to Arthus Reaction:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6HRH1, HMOX1, SELL, TNF
2MP:00020068.6TNF, SELL, ELANE, MIF
3MP:00053977.5HRH1, TNF, SELL, ELANE, MIF, ALOX5
4MP:00053877.5TNF, SELL, ELANE, MIF, ALOX5, HMOX1
5MP:00053767.4TNF, SELL, ELANE, MIF, ALOX5, HMOX1

Publications for Arthus Reaction

About this section

Articles related to Arthus Reaction:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction. (24269785)
2014
2
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). (23511749)
2013
3
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. (19389931)
2009
4
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. (19188484)
2009
5
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. (19513373)
2008
6
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. (12753427)
2003
7
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. (10623857)
2000
8
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. (9331774)
1997
9
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. (9151106)
1997
10
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. (9278109)
1997
11
Role of P-selectin in the early stage of the Arthus reaction. (8886860)
1996
12
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. (8548405)
1995
13
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. (8301139)
1994
14
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. (8066448)
1994
15
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. (8242264)
1993
16
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. (8228810)
1993
17
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. (1388318)
1992
18
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. (1330163)
1992
19
Serotonin metabolism in the arthus reaction. (2136904)
1990
20
Biological and immunological properties of Sugi basic protein-pullulan conjugate. II. Is the reduced ability to elicit the Arthus reaction based on the poor activation of complement by immune complex consisting of anti-Sugi basic protein and Sugi basic protein-pullulan? (2138137)
1990
21
The Arthus reaction in domestic cats. (2969157)
1988
22
Effect of chlorpromazine on the development of experimental glomerulonephritis and Arthus reaction. (2968048)
1988
23
Impaired histamine metabolism in the Arthus reaction induced in guinea-pig skin. (3159351)
1985
24
Effects of PGF2 alpha on the active Arthus reaction in rat and rabbit tongues. (3161844)
1985
25
Immune complexes and inflammation. A study of the activity of anti-inflammatory drugs in the reverse passive arthus reaction in the rat. (6221727)
1983
26
Modification of two models of Arthus reaction in the rat by various drugs. (6460508)
1982
27
The effects of anti-inflammatory and other agents on the rat dermal arthus reaction. (6122238)
1982
28
Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes. (6455972)
1981
29
Transient immune deposits in the papillary dermis and in the epidermis. A light-microscopical study on the experimental Arthus reaction. (6449910)
1980
30
The Arthus reaction in rats, a possible test for anti-inflammatory and antiheumatic drugs. (157676)
1979
31
The effect of sulphinpyrazone and other drugs on the platelet response during the acute phase of the active Arthus reaction in guinea pigs. (158844)
1979
32
Lepromin and the Arthus reaction. (147247)
1977
33
The effect of shock on the inflammatory response. A reevaluation of the role of platelets in the active arthus reaction. (122800)
1975
34
Ultrastructural evidence for lack of tissue damage in a local immune complex reaction: a study of a mild passive Arthus reaction. (125484)
1975
35
Gastrointestinal ulcer--arthus reaction. (4273310)
1974
36
The early changes in the Arthus reaction in the rabbit oral mucosa. (4280437)
1974
37
The requirement for platelets in the active Arthus reaction. (4258952)
1971
38
Effects of neutrophils on tissues. Experiments on the Arthus reaction, the flare phenomenon, and post-phagocytic release of lysosomal enzymes. (4243806)
1969
39
Adrenal medullary hormones and phenothiazine: effects on the Arthus reaction in adult rabbits. (4389807)
1969
40
Leukoegresin: a factor from rabbit skin associated with leucocytic emigration in the Arthus reaction. (4234575)
1968
41
The Arthus reaction to Candida albicans in asthma patients. (4237283)
1968
42
Inhibitory effect of large doses of histamine on the passive Arthus reaction. (4225450)
1967
43
Hyperacute encephalitis resembling the Arthus-reaction. (4239964)
1966
44
ARTHUS REACTION IN THE ORAL CAVITY OF LABORATORY ANIMALS. (14248775)
1965
45
Fluorescent protein tracer studies in allergic reactions. I. The fate of fluorescent antigen in active and passive Arthus reaction in the guinea-pig skin. (14482093)
1961
46
Prevention by intravenous injection of antigen and antibody of passive Arthus reaction to unrelated immune system. (13675297)
1959
47
Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. (13142698)
1954
48
Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. (13037728)
1952
49
Effect of 17-hydroxy-11-dehydrocorticosterone (compound E) and of ACTH on arthus reaction and antibody formation in the rabbit. (14781192)
1950
50
Effect of salicylate and tripelennamine hydrochloride (pyribenzamine) on the Arthus reaction and on bacterial allergic reactions. (18900017)
1947

Variations for Arthus Reaction

About this section

Expression for genes affiliated with Arthus Reaction

About this section
Search GEO for disease gene expression data for Arthus Reaction.

Pathways for genes affiliated with Arthus Reaction

About this section

Pathways related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ELANE, SELL
2
Show member pathways
Immune response Alternative complement pathway58
Immune response Lectin Induced complement pathway58
Immune response Classic complement pathway58
9.6CD46, CR1
39.5TNF, ELANE
4
Show member pathways
9.5ELANE, TNF
59.5MIF, TNF
69.4HMOX1, TNF
79.3CR1, TNF
89.3ALOX5, HMOX1, CD46
99.0TNF, CXCL2
10
Show member pathways
8.9CR1, ALOX5, TNF
118.7MIF, CXCL2, TNF
128.5CR1, CXCL2, TNF
13
Show member pathways
8.2ALOX5, MIF, CXCL2, TNF

Compounds for genes affiliated with Arthus Reaction

About this section

Compounds related to Arthus Reaction according to GeneCards Suite gene sharing:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1bromelain4310.1SELL, ELANE
2boswellic acids4310.0ELANE, ALOX5
3mizolastine439.9HRH1, ALOX5
4manoalide439.9ALOX5, ELANE
5tenidap43 2810.5ALOX5, ELANE, TNF
6pentoxifylline43 1210.5ELANE, SELL, TNF
7anti-histamine439.4HRH1, ALOX5
8thalidomide43 49 59 1212.4MIF, SELL, TNF
9imidazole439.4HRH1, HMOX1, ALOX5
10zymosan439.4TNF, ELANE, CR1
11alpha tocopherol439.3HMOX1, ALOX5, ELANE
12ndga439.3HRH1, ALOX5, TNF
13epinephrine43 24 1211.3SELL, ELANE, ALOX5, HRH1
14rolipram43 59 2811.2ALOX5, ELANE, SELL, TNF
15paraffin439.1SELL, MIF, CR1, CD46
16herbimycin a43 5910.1TNF, SELL, MIF, ALOX5
17prednisolone43 28 1211.0TNF, SELL, CR1
18prostacyclin439.0HMOX1, ALOX5, ELANE, TNF
19curcumin439.0TNF, MIF, ALOX5, HMOX1
20genistein43 28 59 2 24 1213.9TNF, SELL, MIF, ALOX5
21norepinephrine43 24 1210.9SELL, ELANE, MIF, HMOX1, HRH1
22aspirin43 49 28 2411.9SELL, ELANE, ALOX5, HMOX1, HRH1
23manganese superoxide438.9TNF, CXCL2, HMOX1
24atorvastatin43 49 28 24 1212.8SELL, HMOX1, TNF
25n-formylmethionyl-leucylphenylalanine438.7TNF, SELL, ELANE, ALOX5, CR1
26alanine438.7HRH1, CD46, HMOX1, MIF, SELL
27leukotriene b443 59 2410.7TNF, SELL, ELANE, ALOX5, CR1
28fmlp438.7TNF, SELL, ELANE, ALOX5, CR1
29sp 60012543 599.6TNF, CXCL2, HMOX1
30superoxide43 249.6HMOX1, CR1, ELANE, SELL, TNF
31indomethacin43 28 59 1211.6TNF, SELL, ALOX5, HMOX1, HRH1
32histamine43 28 2410.6TNF, SELL, ALOX5, HMOX1, HRH1
33n acetylcysteine438.5TNF, CXCL2, ALOX5, HMOX1
34prostaglandin438.4TNF, CXCL2, ALOX5, HRH1
35estrogen438.3HMOX1, ALOX5, MIF, ELANE, CXCL2
36retinoic acid43 249.3TNF, SELL, ELANE, MIF, CR1, HMOX1
37cycloheximide438.2TNF, SELL, ALOX5, CR1, HMOX1, CD46
38cyclosporin a43 28 5910.1TNF, ELANE, CR1, HMOX1, CD46, HRH1
39lactate438.0TNF, SELL, CXCL2, ELANE, MIF, HMOX1
40rantes437.9TNF, SELL, CXCL2, MIF, CD46, HRH1
41sb 20358043 598.9TNF, SELL, CXCL2, MIF, ALOX5, HMOX1
42vegf437.9TNF, SELL, CXCL2, MIF, ALOX5, HMOX1
43serine437.7TNF, SELL, CXCL2, ELANE, MIF, ALOX5
44arachidonic acid43 28 24 1210.6TNF, CXCL2, MIF, ALOX5, CR1, HRH1
45h2o2437.6TNF, SELL, CXCL2, ELANE, MIF, ALOX5
46endotoxin437.4HRH1, TNF, SELL, CXCL2, ELANE, MIF
47nitric oxide43 24 129.2TNF, CXCL2, MIF, CR1, HMOX1, CD46
48pge2437.1TNF, SELL, CXCL2, ELANE, MIF, ALOX5
49oxygen43 248.1TNF, SELL, CXCL2, ELANE, MIF, ALOX5
50dexamethasone43 49 28 1210.1TNF, SELL, CXCL2, MIF, ALOX5, HMOX1

GO Terms for genes affiliated with Arthus Reaction

About this section

Cellular components related to Arthus Reaction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:00099868.2CD46, CR1, MIF, ELANE, TNF
2integral component of plasma membraneGO:00058878.2HRH1, CD46, CR1, SELL, TNF
3extracellular spaceGO:00056157.5TNF, CXCL2, MIF, ALOX5, HMOX1

Biological processes related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:020003439.7MIF, TNF
2positive regulation of interleukin-8 biosynthetic processGO:00454169.7TNF, ELANE
3regulation of complement activationGO:00304499.7CD46, CR1
4negative regulation of growth of symbiont in hostGO:00441309.6ELANE, TNF
5positive regulation of chemokine biosynthetic processGO:00450809.5TNF, HMOX1
6complement activation, classical pathwayGO:00069589.5CD46, CR1
7positive regulation of cytokine secretionGO:00507159.5TNF, MIF
8positive regulation of peptidyl-serine phosphorylationGO:00331389.5MIF, TNF
9positive regulation of MAP kinase activityGO:00434069.4TNF, ELANE, MIF
10positive regulation of smooth muscle cell proliferationGO:00486619.3HMOX1, ELANE, TNF
11negative regulation of gene expressionGO:00106299.3CD46, MIF, TNF
12intrinsic apoptotic signaling pathway in response to DNA damageGO:00086309.1HMOX1, TNF
13inflammatory responseGO:00069548.4TNF, CXCL2, MIF, HRH1

Molecular functions related to Arthus Reaction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020208.9ELANE, SELL, TNF
2protein bindingGO:00055157.3SELL, CXCL2, ELANE, MIF, ALOX5, CD46

Products for genes affiliated with Arthus Reaction

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Arthus Reaction

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet