MCID: ART006
MIFTS: 37

Arthus Reaction malady

Category: Immune diseases

Aliases & Classifications for Arthus Reaction

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Aliases & Descriptions for Arthus Reaction:

Name: Arthus Reaction 11 50 39 13 68
Arthus Type Urticaria 11
 
Arthus Phenomenon 11

Classifications:



External Ids:

Disease Ontology11 DOID:1556
ICD1030 T78.41
ICD9CM32 995.21
SNOMED-CT62 29548007, 402413008
MeSH39 D001183
NCIt45 C34400

Summaries for Arthus Reaction

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Wikipedia:71 In immunology, the Arthus reaction (/ˌɑːrˈtuːs/, /ˌɑːrˈtjuːs/) is a type... more...

MalaCards based summary: Arthus Reaction, also known as arthus type urticaria, is related to chromophobe adenoma and tick paralysis. An important gene associated with Arthus Reaction is SELL (Selectin L), and among its related pathways are African trypanosomiasis and Interleukin-10 signaling. Affiliated tissues include skin, neutrophil and testes, and related mouse phenotypes are neoplasm and cardiovascular system.

Related Diseases for Arthus Reaction

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Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1chromophobe adenoma10.3ICAM1, SELL
2tick paralysis10.3ICAM1, SELL
3hypotrichosis-lymphedema-telangiectasia-renal defect syndrome10.2SELL, TNF
4phlegmonous dacryocystitis10.2ICAM1, SELL
5hypotrichosis 410.2ICAM1, TNF
6uveitis10.2ICAM1, TNF
7right ventricle hypoplasia10.2ICAM1, TNF
8dermatomycosis10.2ICAM1, TNF
9ulcerative proctitis10.2ALOX5, TNF
10neurotic disorder10.2ICAM1, TNF
11perrault syndrome10.2ICAM1, SELL
12grix blankenship peterson syndrome10.2SELL, TNF
13venezuelan hemorrhagic fever10.2ICAM1, TNF
14conduct disorder10.2ICAM1, TNF
15craniopharyngioma10.2ICAM1, SELL
16central cord syndrome10.2ICAM1, NOS2
17subacute glomerulonephritis10.2ELANE, ICAM1
18radial defect robin sequence10.2ELANE, TNF
19hemangioma of orbit10.2ELANE, TNF
20idiopathic hypertrophic pachymeningitis10.2NOS2, TNF
21tetanus10.2ELANE, TNF
22omsk hemorrhagic fever10.2ELANE, SELL
23amyotrophic lateral sclerosis type 1410.1NOS2, TNF
24xerophthalmia10.1ICAM1, SELL
25epimerase deficiency galactosemia10.1NOS2, TNF
26oral cavity cancer10.1ICAM1, TNF
27pulpitis10.1NOS2, TNF
28acquired thrombocytopenia10.1NOS2, TNF
29mycoplasmal pneumonia10.1HMOX1, TNF
30ectodermal dysplasia bartalos type10.1NOS2, TNF
31autoimmune-related retinopathy and optic neuropathy10.1ALOX5, ICAM1, TNF
32erb-duchenne and dejerine-klumpke palsies10.1ICAM1, TNF
33powassan encephalitis10.1ICAM1, TNF
34geniculate ganglionitis10.1CR1, ICAM1, TNF
35hyperuricemia, pulmonary hypertension, renal failure, and alkalosis10.0ELANE, SELL, TNF
36pyelonephritis10.0ICAM1, NOS2, TNF
37microscopic breast papilloma10.0ICAM1, NOS2, TNF
38acute chest syndrome10.0ELANE, ICAM1, TNF
39pemphigus10.0CD46, CR1
40collagenous colitis10.0ICAM1, NOS2, TNF
41microcephaly10.0ICAM1, TNF
42juvenile amyotrophic lateral sclerosis with dementia10.0CD46, TNF
43spontaneous ocular nystagmus10.0ALOX5, ELANE, TNF
44advanced sleep phase syndrome, familial, 110.0ICAM1, NOS2, TNF
45strawberry gallbladder10.0ALOX5, ICAM1, SELL, TNF
46mucinous ovarian cystadenoma9.9HMOX1, ICAM1, NOS2
47zellweger syndrome9.9HMOX1, NOS2, TNF
48retinitis pigmentosa 519.9ELANE, HMOX1, TNF
49vasculitis9.9
50eating disorder9.9ELANE, ICAM1, SELL, TNF

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to arthus reaction

Symptoms & Phenotypes for Arthus Reaction

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MGI Mouse Phenotypes related to Arthus Reaction according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.3ELANE, ICAM1, NOS2, SELL, TNF
2MP:00053857.9ALOX5, CD46, HMOX1, ICAM1, NOS2, SELL
3MP:00053977.8ALOX5, ELANE, HMOX1, ICAM1, NOS2, SELL
4MP:00053877.8ALOX5, ELANE, HMOX1, ICAM1, NOS2, SELL

Drugs & Therapeutics for Arthus Reaction

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Arthus Reaction


Cochrane evidence based reviews: arthus reaction

Genetic Tests for Arthus Reaction

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Anatomical Context for Arthus Reaction

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MalaCards organs/tissues related to Arthus Reaction:

36
Skin, Neutrophil, Testes, Skeletal muscle, Lung, Tongue, Eye

Publications for Arthus Reaction

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Articles related to Arthus Reaction:

(show top 50)    (show all 158)
idTitleAuthorsYear
1
Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction. (27753135)
2016
2
Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction. (24269785)
2014
3
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. (23096126)
2013
4
Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. (23800055)
2013
5
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). (23511749)
2013
6
Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. (23381473)
2013
7
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction. (22784785)
2012
8
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. (20008131)
2010
9
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. (19389931)
2009
10
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. (19188484)
2009
11
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. (19513373)
2008
12
Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide. (18505425)
2008
13
Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction. (17299025)
2007
14
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. (15728518)
2005
15
Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. (14745115)
2004
16
Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production. (15517609)
2004
17
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. (12753427)
2003
18
Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration. (11918584)
2002
19
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. (11884469)
2002
20
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. (12379763)
2002
21
Transcription factor decoy oligodeoxynucleotides to nuclear factor-kappaB inhibit reverse passive Arthus reaction in rat. (11692225)
2001
22
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. (11238587)
2001
23
Arthus reaction to recombinant hepatitis B virus vaccine. (11512098)
2001
24
Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea. (11316727)
2001
25
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. (10623857)
2000
26
A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. (10843715)
2000
27
The Arthus reaction in rodents: species-specific requirement of complement. (10605043)
2000
28
Contribution of B(2) receptors for bradykinin in arthus reaction-induced plasma extravasation in wild-type or B(2) transgenic knockout mice. (10780980)
2000
29
On the role of complement and Fc gamma-receptors in the Arthus reaction. (10698344)
1999
30
Roles of endothelins and their receptors in immune complex-induced/polymorphonuclear-mediated lung injury (reversed passive arthus reaction) in CD-1 mice. (9918750)
1998
31
Streptococcal and staphylococcal superantigen-induced lymphocytic arteritis in a local type experimental model: comparison with acute vasculitis in the Arthus reaction. (9452132)
1998
32
Nitric oxide inhibits neutrophil infiltration in the reverse passive arthus reaction in rat skin. (9826072)
1998
33
P-selectin requirement for neutrophil accumulation and injury in the direct passive Arthus reaction. (9649192)
1998
34
In vivo inflammatory response to a prototypic B cell superantigen: elicitation of an Arthus reaction by staphylococcal protein A. (9605120)
1998
35
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. (9151106)
1997
36
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. (9278109)
1997
37
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. (9331774)
1997
38
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. (9271590)
1997
39
ICAM-1 mediates leukocyte-endothelium adhesive interactions in the reversed passive Arthus reaction. (8604010)
1996
40
The role of CD11/CD18 integrins in the reverse passive Arthus reaction in rat dermal tissue. (8603998)
1996
41
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. (8769481)
1996
42
A dominant role for mast cell Fc receptors in the Arthus reaction. (8885871)
1996
43
Role of P-selectin in the early stage of the Arthus reaction. (8886860)
1996
44
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. (8548405)
1995
45
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. (8066448)
1994
46
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. (8301139)
1994
47
Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators. (7889293)
1994
48
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. (8242264)
1993
49
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. (8228810)
1993
50
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. (1388318)
1992

Variations for Arthus Reaction

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Expression for genes affiliated with Arthus Reaction

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Search GEO for disease gene expression data for Arthus Reaction.

Pathways for genes affiliated with Arthus Reaction

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GO Terms for genes affiliated with Arthus Reaction

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Cellular components related to Arthus Reaction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:000989710.2ICAM1, SELL, TNF
2extracellular spaceGO:00056158.7ALOX5, ELANE, HMOX1, ICAM1, TNF
3cell surfaceGO:00099868.7CD46, CR1, ELANE, ICAM1, SELL, TNF
4integral component of plasma membraneGO:00058878.4CD46, CR1, ICAM1, SELL, TNF

Biological processes related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of leukocyte adhesion to vascular endothelial cellGO:190499610.4ICAM1, TNF
2positive regulation of nitric oxide biosynthetic processGO:004542910.4ICAM1, TNF
3acute inflammatory response to antigenic stimulusGO:000243810.3ELANE, ICAM1
4negative regulation of growth of symbiont in hostGO:004413010.2ELANE, TNF
5positive regulation of interleukin-8 biosynthetic processGO:004541610.2ELANE, TNF
6negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGO:190204210.0HMOX1, ICAM1
7intrinsic apoptotic signaling pathway in response to DNA damageGO:000863010.0HMOX1, TNF
8positive regulation of chemokine biosynthetic processGO:00450809.9HMOX1, TNF
9cellular response to lipopolysaccharideGO:00712229.8ICAM1, NOS2, TNF
10positive regulation of vasodilationGO:00459099.7HMOX1, NOS2
11defense response to bacteriumGO:00427429.6ELANE, NOS2, TNF
12negative regulation of gene expressionGO:00106299.6CD46, NOS2, TNF
13leukocyte migrationGO:00509009.6ELANE, ICAM1, SELL, TNF
14response to lipopolysaccharideGO:00324969.5ELANE, ICAM1, NOS2
15neutrophil degranulationGO:00433129.5ALOX5, CR1, ELANE, SELL
16positive regulation of smooth muscle cell proliferationGO:00486619.4ELANE, HMOX1, TNF
17response to hypoxiaGO:00016669.3HMOX1, ICAM1, NOS2
18viral entry into host cellGO:00467189.2CD46, CR1, ICAM1

Molecular functions related to Arthus Reaction according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:00020209.7ELANE, SELL, TNF
2virus receptor activityGO:00016189.2CD46, CR1, ICAM1

Sources for Arthus Reaction

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet