MCID: ART006
MIFTS: 51

Arthus Reaction malady

Skin diseases, Immune diseases categories

Summaries for Arthus Reaction

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66Wikipedia, 34MalaCards
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Wikipedia:66 In immunology, the Arthus reaction (/??r?tu?s/, /??r?tju?s/) is a type of local type III... more...

MalaCards: Arthus Reaction, also known as arthus type urticaria, is related to vasculitis and peritonitis. An important gene associated with Arthus Reaction is SELL (selectin L), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Complement Pathway. The compounds bromelain and boswellic acids have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Arthus Reaction

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9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 28ICD9CM, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Immune diseases


Aliases & Descriptions:

arthus reaction 9 46 63
arthus type urticaria 9
arthus phenomenon 9


External Ids:

Disease Ontology9 DOID:1556
MeSH36 D001183
SNOMED-CT59 29548007, 402413008
ICD9CM28 995.21
NCIt41 C34400

Related Diseases for Arthus Reaction

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18GeneCards, 19GeneDecks
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Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 91)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.6CD46, ELANE, SELL, TNF
2peritonitis30.3CR1, ALOX5, CXCL2, TNF
3arthritis30.3SELL, TNF
4glomerulonephritis30.1ELANE, MIF, ALOX5, CR1, CD46
5asthma29.9TNF, SELL, ELANE, MIF, ALOX5, CR1
6pneumonia29.9TNF, SELL, CXCL2, ELANE, CR1, HMOX1
7hepatitis b10.3
8hepatitis10.3
9thrombocytopenia10.3
10diphtheria10.1
11shwartzman phenomenon10.1
12encephalitis10.1
13eosinophilia10.1
14pertussis10.1
15pleurisy10.1
16thyroiditis10.1
17cryptococcosis10.1SELL
18conjunctivitis10.1HRH1
19bronchopulmonary dysplasia10.1SELL, ELANE
20extrinsic allergic alveolitis10.1ELANE, SELL
21kawasaki disease10.1ELANE, SELL
22keratitis10.1MIF, CXCL2
23chorioamnionitis10.1TNF, ELANE
24respiratory failure10.1ALOX5, ELANE
25pulmonary sarcoidosis10.1SELL, TNF
26behcet's disease10.1TNF, SELL
27pulmonary emphysema10.1HMOX1, ELANE
28allergic rhinitis10.0HRH1, ALOX5
29periodontal disease10.0ELANE, TNF
30angioedema10.0ALOX5, HRH1
31aneurysm10.0ALOX5, ELANE, SELL
32periodontitis10.0ELANE, TNF
33graft versus host disease10.0SELL, TNF
34bronchitis10.0SELL, ALOX5
35gastritis10.0CXCL2, MIF, CD46
36sickle cell disease10.0HMOX1, SELL
37urticaria10.0HRH1, ALOX5
38afibrinogenemia10.0CD46, CR1
39bacterial meningitis10.0CXCL2, CR1
40adult respiratory distress syndrome10.0TNF, ELANE, ALOX5
41cork-handlers' disease10.0HMOX1, ELANE
42allergic asthma10.0HRH1, ALOX5, SELL
43vascular disease10.0CD46, HMOX1, ELANE
44skin disease10.0TNF, SELL, HRH1
45pulmonary fibrosis10.0HMOX1, ALOX5, ELANE
46arthropathy10.0ALOX5, TNF
47insulin resistance10.0TNF, SELL, MIF
48psoriasis10.0ALOX5, ELANE, TNF
49systemic scleroderma10.0CD46, ALOX5, MIF, SELL
50osteoarthritis10.0TNF, CXCL2, ALOX5

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to arthus reaction

Symptoms for Arthus Reaction

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Drugs & Therapeutics for Arthus Reaction

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Arthus Reaction

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Anatomical Context for Arthus Reaction

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34MalaCards
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MalaCards organs/tissues related to Arthus Reaction:

34
Skin, Testes, Lung, Skeletal muscle, Tongue, Eye, Thyroid, B cells

Animal Models for Arthus Reaction or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Arthus Reaction:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6HRH1, HMOX1, SELL, TNF
2MP:00020068.6TNF, SELL, ELANE, MIF
3MP:00053977.5HRH1, TNF, SELL, ELANE, MIF, ALOX5
4MP:00053877.5TNF, SELL, ELANE, MIF, ALOX5, HMOX1
5MP:00053767.4TNF, SELL, ELANE, MIF, ALOX5, HMOX1

Publications for Arthus Reaction

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53PubMed
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Articles related to Arthus Reaction:

(show top 50)    (show all 157)
idTitleAuthorsYear
1
Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction. (24269785)
2014
2
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). (23511749)
2013
3
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. (19389931)
2009
4
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. (19188484)
2009
5
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. (19513373)
2008
6
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. (12753427)
2003
7
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. (10623857)
2000
8
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. (9331774)
1997
9
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. (9151106)
1997
10
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. (9278109)
1997
11
Role of P-selectin in the early stage of the Arthus reaction. (8886860)
1996
12
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. (8548405)
1995
13
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. (8301139)
1994
14
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. (8066448)
1994
15
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. (8242264)
1993
16
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. (8228810)
1993
17
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. (1388318)
1992
18
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. (1330163)
1992
19
Serotonin metabolism in the arthus reaction. (2136904)
1990
20
Biological and immunological properties of Sugi basic protein-pullulan conjugate. II. Is the reduced ability to elicit the Arthus reaction based on the poor activation of complement by immune complex consisting of anti-Sugi basic protein and Sugi basic protein-pullulan? (2138137)
1990
21
The Arthus reaction in domestic cats. (2969157)
1988
22
Effect of chlorpromazine on the development of experimental glomerulonephritis and Arthus reaction. (2968048)
1988
23
Impaired histamine metabolism in the Arthus reaction induced in guinea-pig skin. (3159351)
1985
24
Effects of PGF2 alpha on the active Arthus reaction in rat and rabbit tongues. (3161844)
1985
25
Immune complexes and inflammation. A study of the activity of anti-inflammatory drugs in the reverse passive arthus reaction in the rat. (6221727)
1983
26
Modification of two models of Arthus reaction in the rat by various drugs. (6460508)
1982
27
The effects of anti-inflammatory and other agents on the rat dermal arthus reaction. (6122238)
1982
28
Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes. (6455972)
1981
29
Transient immune deposits in the papillary dermis and in the epidermis. A light-microscopical study on the experimental Arthus reaction. (6449910)
1980
30
The Arthus reaction in rats, a possible test for anti-inflammatory and antiheumatic drugs. (157676)
1979
31
The effect of sulphinpyrazone and other drugs on the platelet response during the acute phase of the active Arthus reaction in guinea pigs. (158844)
1979
32
Lepromin and the Arthus reaction. (147247)
1977
33
The effect of shock on the inflammatory response. A reevaluation of the role of platelets in the active arthus reaction. (122800)
1975
34
Ultrastructural evidence for lack of tissue damage in a local immune complex reaction: a study of a mild passive Arthus reaction. (125484)
1975
35
Gastrointestinal ulcer--arthus reaction. (4273310)
1974
36
The early changes in the Arthus reaction in the rabbit oral mucosa. (4280437)
1974
37
The requirement for platelets in the active Arthus reaction. (4258952)
1971
38
Effects of neutrophils on tissues. Experiments on the Arthus reaction, the flare phenomenon, and post-phagocytic release of lysosomal enzymes. (4243806)
1969
39
Adrenal medullary hormones and phenothiazine: effects on the Arthus reaction in adult rabbits. (4389807)
1969
40
Leukoegresin: a factor from rabbit skin associated with leucocytic emigration in the Arthus reaction. (4234575)
1968
41
The Arthus reaction to Candida albicans in asthma patients. (4237283)
1968
42
Inhibitory effect of large doses of histamine on the passive Arthus reaction. (4225450)
1967
43
Hyperacute encephalitis resembling the Arthus-reaction. (4239964)
1966
44
ARTHUS REACTION IN THE ORAL CAVITY OF LABORATORY ANIMALS. (14248775)
1965
45
Fluorescent protein tracer studies in allergic reactions. I. The fate of fluorescent antigen in active and passive Arthus reaction in the guinea-pig skin. (14482093)
1961
46
Prevention by intravenous injection of antigen and antibody of passive Arthus reaction to unrelated immune system. (13675297)
1959
47
Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. (13142698)
1954
48
Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. (13037728)
1952
49
Effect of 17-hydroxy-11-dehydrocorticosterone (compound E) and of ACTH on arthus reaction and antibody formation in the rabbit. (14781192)
1950
50
Effect of salicylate and tripelennamine hydrochloride (pyribenzamine) on the Arthus reaction and on bacterial allergic reactions. (18900017)
1947

Variations for Arthus Reaction

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Expression for genes affiliated with Arthus Reaction

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for genes affiliated with Arthus Reaction

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51PathCards, 61Thomson Reuters, 54QIAGEN, 56Reactome, 58SinoBiological, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology
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Pathways related to Arthus Reaction according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ELANE, SELL
2
Show member pathways
Immune response Alternative complement pathway61
Immune response Lectin Induced complement pathway61
Immune response Classic complement pathway61
9.6CD46, CR1
39.5TNF, ELANE
4
Show member pathways
9.5ELANE, TNF
59.5MIF, TNF
69.4HMOX1, TNF
79.3CR1, TNF
89.3ALOX5, HMOX1, CD46
99.0TNF, CXCL2
10
Show member pathways
8.9CR1, ALOX5, TNF
118.7MIF, CXCL2, TNF
128.5CR1, CXCL2, TNF
13
Show member pathways
8.2ALOX5, MIF, CXCL2, TNF

Compounds for genes affiliated with Arthus Reaction

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46Novoseek, 30IUPHAR, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 3BitterDB
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Compounds related to Arthus Reaction according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1bromelain4610.1ELANE, SELL
2boswellic acids4610.0ELANE, ALOX5
3mizolastine469.9HRH1, ALOX5
4manoalide469.9ALOX5, ELANE
5tenidap46 3010.5ALOX5, ELANE, TNF
6pentoxifylline46 1210.5SELL, ELANE, TNF
7anti-histamine469.4ALOX5, HRH1
8thalidomide46 52 62 1212.4MIF, SELL, TNF
9imidazole469.4HRH1, HMOX1, ALOX5
10zymosan469.4TNF, CR1, ELANE
11alpha tocopherol469.3HMOX1, ELANE, ALOX5
12ndga469.3HRH1, ALOX5, TNF
13epinephrine46 25 1211.3SELL, ALOX5, ELANE, HRH1
14rolipram46 62 3011.2ALOX5, SELL, TNF, ELANE
15paraffin469.1CD46, MIF, SELL, CR1
16herbimycin a46 6210.1ALOX5, MIF, TNF, SELL
17prednisolone46 30 1211.0SELL, CR1, TNF
18prostacyclin469.0ELANE, HMOX1, TNF, ALOX5
19curcumin469.0HMOX1, ALOX5, TNF, MIF
20genistein46 30 62 3 25 1213.9ALOX5, MIF, SELL, TNF
21norepinephrine46 25 1210.9HMOX1, MIF, ELANE, HRH1, SELL
22aspirin46 52 30 2511.9HRH1, ELANE, SELL, HMOX1, ALOX5
23manganese superoxide468.9TNF, CXCL2, HMOX1
24atorvastatin46 52 30 25 1212.8TNF, HMOX1, SELL
25n-formylmethionyl-leucylphenylalanine468.7ELANE, CR1, ALOX5, SELL, TNF
26alanine468.7CD46, HRH1, SELL, MIF, HMOX1
27leukotriene b446 62 2510.7TNF, SELL, ELANE, ALOX5, CR1
28fmlp468.7TNF, CR1, SELL, ELANE, ALOX5
29sp 60012546 629.6HMOX1, CXCL2, TNF
30superoxide46 259.6TNF, SELL, CR1, HMOX1, ELANE
31indomethacin46 30 62 1211.6SELL, TNF, ALOX5, HMOX1, HRH1
32histamine46 30 2510.6TNF, SELL, ALOX5, HRH1, HMOX1
33n acetylcysteine468.5TNF, CXCL2, ALOX5, HMOX1
34prostaglandin468.4CXCL2, TNF, ALOX5, HRH1
35estrogen468.3CXCL2, ELANE, HMOX1, ALOX5, MIF
36retinoic acid46 259.3HMOX1, MIF, ELANE, CR1, TNF, SELL
37cycloheximide468.2HMOX1, CR1, ALOX5, SELL, TNF, CD46
38cyclosporin a46 30 6210.1TNF, ELANE, CR1, HMOX1, CD46, HRH1
39lactate468.0MIF, SELL, HMOX1, TNF, CXCL2, ELANE
40rantes467.9TNF, SELL, CXCL2, MIF, CD46, HRH1
41sb 20358046 628.9ALOX5, HMOX1, TNF, SELL, CXCL2, MIF
42vegf467.9SELL, ALOX5, MIF, HMOX1, CXCL2, TNF
43serine467.7CD46, TNF, MIF, ALOX5, SELL, ELANE
44arachidonic acid46 30 25 1210.6HRH1, CR1, TNF, CXCL2, MIF, ALOX5
45h2o2467.6TNF, HMOX1, SELL, ALOX5, MIF, ELANE
46endotoxin467.4HRH1, SELL, CXCL2, ELANE, MIF, CR1
47nitric oxide46 25 129.2MIF, CXCL2, TNF, CR1, HMOX1, CD46
48pge2467.1MIF, HRH1, HMOX1, TNF, SELL, CXCL2
49oxygen46 258.1TNF, SELL, ELANE, MIF, CXCL2, ALOX5
50dexamethasone46 52 30 1210.1ALOX5, HMOX1, TNF, SELL, CXCL2, CD46

GO Terms for genes affiliated with Arthus Reaction

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17Gene Ontology
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Cellular components related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.2CD46, CR1, MIF, ELANE, TNF
2integral component of plasma membraneGO:0058878.2HRH1, CD46, CR1, SELL, TNF
3extracellular spaceGO:0056157.5TNF, CXCL2, MIF, ALOX5, HMOX1

Biological processes related to Arthus Reaction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7MIF, TNF
2positive regulation of interleukin-8 biosynthetic processGO:0454169.7TNF, ELANE
3regulation of complement activationGO:0304499.7CD46, CR1
4negative regulation of growth of symbiont in hostGO:0441309.6ELANE, TNF
5positive regulation of chemokine biosynthetic processGO:0450809.5TNF, HMOX1
6complement activation, classical pathwayGO:0069589.5CD46, CR1
7positive regulation of cytokine secretionGO:0507159.5TNF, MIF
8positive regulation of peptidyl-serine phosphorylationGO:0331389.5MIF, TNF
9positive regulation of MAP kinase activityGO:0434069.4TNF, ELANE, MIF
10positive regulation of smooth muscle cell proliferationGO:0486619.3HMOX1, ELANE, TNF
11negative regulation of gene expressionGO:0106299.3CD46, MIF, TNF
12intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1HMOX1, TNF
13inflammatory responseGO:0069548.4TNF, CXCL2, MIF, HRH1

Molecular functions related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020208.9ELANE, SELL, TNF
2protein bindingGO:0055157.3SELL, CXCL2, ELANE, MIF, ALOX5, CD46

Products for genes affiliated with Arthus Reaction

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  • Antibodies
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Sources for Arthus Reaction

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet