MCID: ART006
MIFTS: 48

Arthus Reaction malady

Summaries for Arthus Reaction

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63Wikipedia, 32MalaCards
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Wikipedia:63 In immunology, the Arthus reaction (/ˌɑrˈtuːs/, /ˌɑrˈtjuːs/) is a type of local type III... more...

MalaCards: Arthus Reaction, also known as arthus type urticaria, is related to vasculitis and thrombocytopenia. An important gene associated with Arthus Reaction is SELL (selectin L), and among its related pathways are Classical antibody-mediated complement activation and Immune response MIF-mediated glucocorticoid regulation. The compounds bromelain and pge2 have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and skeletal muscle, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Arthus Reaction

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8Disease Ontology, 44Novoseek, 60UMLS, 27ICD9CM, 39NCIt, 34MeSH, 56SNOMED-CT
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Aliases & Descriptions:

arthus reaction 8 44 60
arthus type urticaria 8
arthus phenomenon 8


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Disease Ontology8 DOID:1556
ICD9CM27 995.21
SNOMED-CT56 402413008, 29548007
NCIt39 C34400
MeSH34 D001183

Related Diseases for Arthus Reaction

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17GeneCards, 18GeneDecks
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Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.5SELL, TNF, CD46, ELANE
2thrombocytopenia30.3ALOX5, CD46
3hepatitis30.3SELL, CR1
4hepatitis b30.3CR1, MIF
5peritonitis30.3CXCL2, TNF, CR1, ALOX5, FCGR1A
6encephalitis30.1CD46
7arthritis30.1SELL, TNF
8glomerulonephritis30.1CD46, ELANE, ALOX5, MIF, CR1
9pneumonia30.1ELANE, HMOX1, SELL, TNF, HRH1, CXCL2
10asthma30.1CR1, MIF, HRH1, TNF, SELL, ALOX5
11diphtheria10.1
12factor xii deficiency10.1
13shwartzman phenomenon10.1
14eosinophilia10.1
15pertussis10.1
16pleurisy10.1
17thyroiditis10.1
18meningitis10.0CD46
19myocardial infarction10.0SELL
20gingivitis10.0ELANE
21myeloid leukemia10.0ELANE
22glioblastoma multiforme10.0CD46
23hemolytic-uremic syndrome10.0CD46
24disseminated intravascular coagulation10.0ELANE
25bronchiectasis10.0ELANE
26rhinitis10.0HRH1
27acute myocardial infarction10.0MIF
28wegener's granulomatosis10.0ELANE
29atopy10.0MIF
30malignant glioma10.0CD46
31crohn's disease10.0TNF
32uveitis10.0TNF
33bronchopulmonary dysplasia10.0SELL, ELANE
34hypersensitivity reaction type ii disease10.0TNF
35synovitis10.0TNF
36kawasaki disease10.0ELANE, SELL
37dermatitis10.0ALOX5
38sinusitis10.0ALOX5
39pancreatitis10.0ELANE
40coronary heart disease10.0ALOX5
41hepatopulmonary syndrome10.0HMOX1
42familial mediterranean fever10.0TNF
43cryptococcosis10.0SELL
44interstitial lung disease10.0TNF
45infertility10.0MIF, CD46
46pancreatic cancer10.0ALOX5
47sickle cell disease10.0HMOX1, SELL
48vitiligo10.0CD46
49nephritis10.0CR1
50extrinsic allergic alveolitis10.0ELANE, SELL

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to arthus reaction

Clinical Features for Arthus Reaction

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Drugs & Therapeutics for Arthus Reaction

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Arthus Reaction

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Anatomical Context for Arthus Reaction

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32MalaCards
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MalaCards organs/tissues related to Arthus Reaction:

32
Skin, Testes, Skeletal muscle, Lung, Eye, Thyroid, B cells, Tongue

Animal Models for Arthus Reaction or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Arthus Reaction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.3SELL, LAT, HMOX1, HRH1, TNF
2MP:00053847.1ALOX5, TNF, SELL, LAT, FCGR1A, HMOX1
3MP:00053976.9SELL, ELANE, ALOX5, LAT, FCGR1A, HMOX1
4MP:00053766.9TNF, MIF, HRH1, HMOX1, LAT, SELL
5MP:00053876.9TNF, MIF, HRH1, HMOX1, FCGR1A, LAT

Publications for Arthus Reaction

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50PubMed
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Articles related to Arthus Reaction:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). (23511749)
2013
2
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. (19389931)
2009
3
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. (19513373)
2008
4
Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. (14745115)
2004
5
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. (12753427)
2003
6
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. (11238587)
2001
7
The Arthus reaction in rodents: species-specific requirement of complement. (10605043)
2000
8
Contribution of B(2) receptors for bradykinin in arthus reaction-induced plasma extravasation in wild-type or B(2) transgenic knockout mice. (10780980)
2000
9
On the role of complement and Fc gamma-receptors in the Arthus reaction. (10698344)
1999
10
P-selectin requirement for neutrophil accumulation and injury in the direct passive Arthus reaction. (9649192)
1998
11
Nitric oxide inhibits neutrophil infiltration in the reverse passive arthus reaction in rat skin. (9826072)
1998
12
Roles of endothelins and their receptors in immune complex-induced/polymorphonuclear-mediated lung injury (reversed passive arthus reaction) in CD-1 mice. (9918750)
1998
13
Development of antibodies to fetal calf serum with arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions. (9028307)
1997
14
Comparison of the reversed passive Arthus and local Shwartzman reactions of rabbit skin: effects of the long-acting PAF antagonist UK-74,505. (9105704)
1997
15
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. (9271590)
1997
16
A dominant role for mast cell Fc receptors in the Arthus reaction. (8885871)
1996
17
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. (8769481)
1996
18
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. (8066448)
1994
19
Mast cells contribute to fibrin deposition in reverse passive Arthus reaction in mouse skin. (1387612)
1992
20
Biological and immunological properties of Sugi basic protein-pullulan conjugate. II. Is the reduced ability to elicit the Arthus reaction based on the poor activation of complement by immune complex consisting of anti-Sugi basic protein and Sugi basic protein-pullulan? (2138137)
1990
21
The Arthus reaction in domestic cats. (2969157)
1988
22
Inhibitory effect of methyl 7-butyl-4,5,6,7-tetrahydro-3-methylamino-4,6-dioxo-5-propyl-2H-pyrazol o[3, 4-d]pyrimidine-2-carboxylate (AA-2379) on type III allergic (Arthus) reaction. (2975457)
1988
23
Histamine metabolism in the Arthus reaction. (2936618)
1986
24
Suppression of complement-mediated vascular injury at Arthus reaction sites by complement inhibitors. (2943553)
1986
25
A specific antagonist of platelet-activating factor suppresses oedema formation in an Arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin. (2940300)
1986
26
Impaired histamine metabolism in the Arthus reaction induced in guinea-pig skin. (3159351)
1985
27
Ex vivo effects of nonsteroidal antiinflammatory drugs on arachidonic acid metabolism in neutrophils from a reverse passive Arthus reaction. (3156814)
1985
28
Studies on the role of polymorphonuclear leukocyte granule elastase in Arthus reaction. (6240230)
1984
29
Differential effects of pharmacologic agents on the reverse passive Arthus reaction in guinea pigs. (6240931)
1984
30
The effects of anti-inflammatory and other agents on the rat dermal arthus reaction. (6122238)
1982
31
Pathways to inflammation induced by immune complexes: development of the Arthus reaction. (6211371)
1982
32
Demonstration of the phagocytic activity of chicken basophils in the reversed Arthus reaction using colloidal carbon. (6218553)
1982
33
Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes. (6455972)
1981
34
Lepromin and the Arthus reaction. (147247)
1977
35
Distribution of immune deposits in the skin of reversed passive arthus reaction using horseradish peroxidase as antigen. (45717)
1976
36
The Arthus reaction in guinea-pig knee joints. A test for anti-inflammatory drugs. (1220555)
1975
37
Delayed hypersensitivity and Arthus reaction to purified hepatitis B surface antigen (HBsAg) in immunized chimpanzees. (128431)
1975
38
Proceedings: The effect of sulphinpyrazone on the thrombocytopenia occurring in the Arthus reaction. (127637)
1975
39
Use of the reversed passive Arthus reaction as a test for anti-inflammatory agents. (126639)
1975
40
Gastrointestinal ulcer--arthus reaction. (4273310)
1974
41
A comparison between the active cutaneous Arthus reaction and immune-mediated enteroluminal neutrophil emigration in pigs. (4274826)
1974
42
The Forssman skin test and the Arthus reaction. (4267517)
1973
43
Disappearance of immunoglobulin and complement from the Arthus reaction and its relevance to studies of vasculitis in man. (4100978)
1971
44
Prevention of the Arthus reaction in rats and mice by combination of epinephrine and a phenothiazine derivative, propiomazine. (4391446)
1970
45
Influence of induced tuberculin allergy followed by induced Arthus reaction on each other, in rabbits. (4222507)
1966
46
The role of PMN-leukocyte lysosomes in tissue injury, inflammation and hypersensitivity. I. The vascular changes and the role of PMN-leukocytes in the reversed passive Arthus reaction. (4225017)
1966
47
Arthus reaction in the mouse and the rat after intralabial injection of antigens. (13295601)
1956
48
Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. (13142698)
1954
49
Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. (13037728)
1952
50
Effect of phenergan (N-dimethylamino-2-propyl-1-thiodiphenylamine, 3277 RP) on the Arthus reaction in rabbits. (18136476)
1949

Genetic Variations for Arthus Reaction

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Expression for genes affiliated with Arthus Reaction

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for genes affiliated with Arthus Reaction

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53Reactome, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG
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Compounds for genes affiliated with Arthus Reaction

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44Novoseek, 11DrugBank, 28IUPHAR, 59Tocris Bioscience, 24HMDB, 49PharmGKB, 2BitterDB
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Compounds related to Arthus Reaction according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1bromelain4410.1ELANE, SELL
2pge24410.1CXCL2
3estrogen4410.0CXCL2
4boswellic acids449.9ALOX5, ELANE
5mizolastine449.8HRH1, ALOX5
6cycloheximide449.8SELL, FCGR1A, CR1
7manoalide449.7ALOX5, ELANE
8cilomilast449.6ELANE, TNF
9pentoxifylline44 1110.5ELANE, SELL, TNF
10tenidap44 2810.5ALOX5, ELANE, TNF
11imidazole449.4ALOX5, HMOX1, HRH1
12endotoxin449.3CXCL2, HRH1, SELL
13rolipram44 59 2811.2SELL, ELANE, ALOX5, TNF
14anti-histamine449.2ALOX5, HRH1
15ndga449.2TNF, ALOX5, HRH1
16epinephrine44 11 2411.2ELANE, ALOX5, HRH1, SELL
17zymosan449.1CR1, TNF, ELANE, FCGR1A
18thalidomide44 49 59 1112.1TNF, MIF, SELL
19prednisolone44 28 1111.1SELL, FCGR1A, TNF, CR1
20prostacyclin449.0ALOX5, ELANE, TNF, HMOX1
21norepinephrine44 11 2411.0HRH1, MIF, HMOX1, SELL, ELANE
22curcumin449.0ALOX5, HMOX1, MIF, TNF
23superoxide44 249.9SELL, FCGR1A, HMOX1, TNF, ELANE
24aspirin44 49 28 2411.9HMOX1, HRH1, SELL, ALOX5, ELANE
25herbimycin a44 599.8ALOX5, MIF, FCGR1A, TNF, SELL
26manganese superoxide448.8CXCL2, HMOX1, TNF
27genistein44 28 59 2 11 2413.8ALOX5, SELL, FCGR1A, TNF, MIF
28n-formylmethionyl-leucylphenylalanine448.7SELL, CR1, TNF, ALOX5, ELANE
29leukotriene b444 59 2410.7TNF, SELL, ELANE, CR1, ALOX5
30h2o2448.7MIF, ALOX5, SELL, FCGR1A, CXCL2
31indomethacin44 59 28 1111.6HRH1, HMOX1, SELL, ALOX5, TNF
32histamine44 28 2410.6TNF, HRH1, HMOX1, ALOX5, SELL
33fibrinogen448.5TNF, CXCL2, FCGR1A, ELANE
34fmlp448.4ELANE, ALOX5, FCGR1A, TNF, SELL, CR1
35rantes448.4SELL, HRH1, TNF, CD46, CXCL2
36n acetylcysteine448.4ALOX5, HMOX1, CXCL2, TNF
37prostaglandin448.4ALOX5, TNF, HRH1, CXCL2
38retinoic acid44 249.3ELANE, TNF, CR1, MIF, HMOX1, SELL
39cyclosporin a44 28 5910.2TNF, CR1, CD46, HRH1, HMOX1, ELANE
40lactate448.1MIF, SELL, HMOX1, CXCL2, ELANE, TNF
41serine448.0ALOX5, MIF, CD46, CXCL2, TNF, FCGR1A
42sb 20358044 598.9ALOX5, HMOX1, SELL, CXCL2, MIF, TNF
43vegf447.9ALOX5, CXCL2, SELL, HMOX1, TNF, MIF
44tyrosine447.8MIF, CD46, FCGR1A, LAT, SELL, CR1
45oxygen44 248.6CXCL2, TNF, FCGR1A, SELL, ELANE, CR1
46lipid447.6MIF, CXCL2, HRH1, TNF, FCGR1A, LAT
47nitric oxide44 11 249.3CXCL2, TNF, CR1, MIF, CD46, HMOX1
48arachidonic acid44 28 11 2410.2CXCL2, CR1, MIF, TNF, ALOX5, FCGR1A
49calcium44 49 11 2410.2CXCL2, LAT, FCGR1A, HRH1, CR1, ALOX5
50dexamethasone44 49 28 119.8CD46, CXCL2, HRH1, HMOX1, FCGR1A, MIF

GO Terms for genes affiliated with Arthus Reaction

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16Gene Ontology
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Cellular components related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.3CR1, CD46, HRH1, SELL, TNF
2cell surfaceGO:0099868.1ELANE, CD46, MIF, CR1, TNF

Biological processes related to Arthus Reaction according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7TNF, MIF
2positive regulation of interleukin-8 biosynthetic processGO:0454169.6ELANE, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.5HMOX1, TNF
4positive regulation of cytokine secretionGO:0507159.5MIF, TNF
5negative regulation of growth of symbiont in hostGO:0441309.5TNF, ELANE
6positive regulation of MAP kinase activityGO:0434069.4ELANE, MIF, TNF
7regulation of complement activationGO:0304499.4CD46, CR1
8positive regulation of smooth muscle cell proliferationGO:0486619.4ELANE, HMOX1, TNF
9innate immune responseGO:0450878.8LAT, FCGR1A, CD46, MIF, CR1
10inflammatory responseGO:0069548.2TNF, MIF, CXCL2, HRH1

Molecular functions related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3ELANE, SELL, TNF

Products for genes affiliated with Arthus Reaction

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  • Antibodies
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Sources for Arthus Reaction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet