MCID: ART006
MIFTS: 45

Arthus Reaction malady

Summaries for Arthus Reaction

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64Wikipedia, 33MalaCards
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Wikipedia:64 In immunology, the Arthus reaction (/ˌɑrˈtuːs/, /ˌɑrˈtjuːs/) is a type of local type III... more...

MalaCards: Arthus Reaction, also known as arthus type urticaria, is related to vasculitis and thrombocytopenia. An important gene associated with Arthus Reaction is SELL (selectin L), and among its related pathways are Classical antibody-mediated complement activation and Immune response MIF-mediated glucocorticoid regulation. The compounds pge2 and bromelain have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and lung, and related mouse phenotypes are liver/biliary system and cellular.

Aliases & Classifications for Arthus Reaction

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 27ICD9CM, 40NCIt, 35MeSH, 57SNOMED-CT
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Aliases & Descriptions:

arthus reaction 8 45 61
arthus type urticaria 8
arthus phenomenon 8


External Ids:

Disease Ontology8 DOID:1556
ICD9CM27 995.21
SNOMED-CT57 402413008, 29548007
NCIt40 C34400
MeSH35 D001183

Related Diseases for Arthus Reaction

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.5TNF, CD46, SELL, ELANE
2thrombocytopenia30.4ALOX5, CD46
3arthritis30.2TNF, SELL
4asthma30.1ELANE, TNF, CR1, MIF, HRH1, SELL
5hepatitis a10.3
6hepatitis c10.1
7diphtheria10.1
8hepatitis d10.1
9shwartzman phenomenon10.1
10lymphocytic vasculitis10.1
11immunoglobulin a vasculitis10.1
12meningitis10.0CD46
13myocardial infarction10.0SELL
14gingivitis10.0ELANE
15myeloid leukemia10.0ELANE
16glioblastoma multiforme10.0CD46
17hemolytic-uremic syndrome10.0CD46
18encephalitis10.0CD46
19disseminated intravascular coagulation10.0ELANE
20bronchiectasis10.0ELANE
21rhinitis10.0HRH1
22acute myocardial infarction10.0MIF
23wegener's granulomatosis10.0ELANE
24atopy10.0MIF
25malignant glioma10.0CD46
26crohn's disease10.0TNF
27uveitis10.0TNF
28bronchopulmonary dysplasia10.0ELANE, SELL
29hypersensitivity reaction type ii disease10.0TNF
30synovitis10.0TNF
31kawasaki disease10.0ELANE, SELL
32dermatitis10.0ALOX5
33sinusitis10.0ALOX5
34pancreatitis10.0ELANE
35coronary heart disease10.0ALOX5
36hepatopulmonary syndrome10.0HMOX1
37familial mediterranean fever10.0TNF
38cryptococcosis10.0SELL
39interstitial lung disease10.0TNF
40infertility10.0CD46, MIF
41pancreatic cancer10.0ALOX5
42sickle cell disease10.0HMOX1, SELL
43vitiligo10.0CD46
44nephritis10.0CR1
45extrinsic allergic alveolitis10.0SELL, ELANE
46uremia10.0CR1
47myeloma10.0SELL, FCGR1A
48chorioamnionitis10.0TNF, ELANE
49keratitis10.0MIF, CXCL2
50neutropenia10.0ELANE, ALOX5

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to arthus reaction

Clinical Features for Arthus Reaction

Drugs & Therapeutics for Arthus Reaction

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Arthus Reaction

Drug clinical trials:

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Search NIH Clinical Center for Arthus Reaction

Search CenterWatch for Arthus Reaction

Genetic Tests for Arthus Reaction

Anatomical Context for Arthus Reaction

Sources:
33MalaCards
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MalaCards organs/tissues related to Arthus Reaction:

33
Skin, Tongue, Lung, Skeletal muscle, Thyroid, B cells, Fetal lung, Fetal thyroid

Animal Models for Arthus Reaction or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Arthus Reaction

Sources:
51PubMed
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Articles related to Arthus Reaction:

(show top 50)    (show all 159)
idTitleAuthorsYear
1
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. (23096126)
2013
2
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction. (22784785)
2012
3
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. (20008131)
2010
4
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. (19513373)
2008
5
Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide. (18505425)
2008
6
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. (12753427)
2003
7
The Arthus reaction in rodents: species-specific requirement of complement. (10605043)
2000
8
On the role of complement and Fc gamma-receptors in the Arthus reaction. (10698344)
1999
9
In vivo inflammatory response to a prototypic B cell superantigen: elicitation of an Arthus reaction by staphylococcal protein A. (9605120)
1998
10
P-selectin requirement for neutrophil accumulation and injury in the direct passive Arthus reaction. (9649192)
1998
11
Nitric oxide inhibits neutrophil infiltration in the reverse passive arthus reaction in rat skin. (9826072)
1998
12
Development of antibodies to fetal calf serum with arthus-like reactions in human immunodeficiency virus-infected patients given syngeneic lymphocyte infusions. (9028307)
1997
13
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. (9271590)
1997
14
A dominant role for mast cell Fc receptors in the Arthus reaction. (8885871)
1996
15
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. (8769481)
1996
16
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. (8301139)
1994
17
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. (8066448)
1994
18
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. (8228810)
1993
19
Suppression of vascular injury at the Arthus reaction site by a complement inhibitor, 5,5',5''-(1,3,6-naphthalene-triyl-tris[sulfonylimino])-tris (1,3-benzene disulfonic acid) hexasodium salt. (1828755)
1991
20
Inhibitory effect of methyl 7-butyl-4,5,6,7-tetrahydro-3-methylamino-4,6-dioxo-5-propyl-2H-pyrazol o[3, 4-d]pyrimidine-2-carboxylate (AA-2379) on type III allergic (Arthus) reaction. (2975457)
1988
21
Histamine metabolism in the Arthus reaction. (2936618)
1986
22
Suppression of complement-mediated vascular injury at Arthus reaction sites by complement inhibitors. (2943553)
1986
23
A specific antagonist of platelet-activating factor suppresses oedema formation in an Arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin. (2940300)
1986
24
Impaired histamine metabolism in the Arthus reaction induced in guinea-pig skin. (3159351)
1985
25
Effects of PGF2 alpha on the active Arthus reaction in rat and rabbit tongues. (3161844)
1985
26
Studies on the role of polymorphonuclear leukocyte granule elastase in Arthus reaction. (6240230)
1984
27
Differential effects of pharmacologic agents on the reverse passive Arthus reaction in guinea pigs. (6240931)
1984
28
Immune complexes and inflammation. A study of the activity of anti-inflammatory drugs in the reverse passive arthus reaction in the rat. (6221727)
1983
29
Modification of two models of Arthus reaction in the rat by various drugs. (6460508)
1982
30
The effects of anti-inflammatory and other agents on the rat dermal arthus reaction. (6122238)
1982
31
Demonstration of the phagocytic activity of chicken basophils in the reversed Arthus reaction using colloidal carbon. (6218553)
1982
32
Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes. (6455972)
1981
33
Polymorphonuclear leukocyte-inhibitory factor of Bordetella pertussis. III. Inhibition of Arthus reaction and peritoneal infiltration of PMN. (6258031)
1980
34
Lepromin and the Arthus reaction. (147247)
1977
35
Ultrastructural evidence for lack of tissue damage in a local immune complex reaction: a study of a mild passive Arthus reaction. (125484)
1975
36
Proceedings: The effect of sulphinpyrazone on the thrombocytopenia occurring in the Arthus reaction. (127637)
1975
37
Suppression of the arthus reaction in the guinea-pig by dapsone. (129775)
1975
38
Use of the reversed passive Arthus reaction as a test for anti-inflammatory agents. (126639)
1975
39
The papulonecrotic tuberculide. From Arthus reaction to lupus vulgaris. (4279670)
1974
40
A comparison between the active cutaneous Arthus reaction and immune-mediated enteroluminal neutrophil emigration in pigs. (4274826)
1974
41
Biochemical and cellular changes in the Arthus reaction. (4270155)
1973
42
The Forssman skin test and the Arthus reaction. (4267517)
1973
43
Prevention of the Arthus reaction in rats and mice by combination of epinephrine and a phenothiazine derivative, propiomazine. (4391446)
1970
44
Inhibitory effect of large doses of histamine on the passive Arthus reaction. (4225450)
1967
45
Influence of induced tuberculin allergy followed by induced Arthus reaction on each other, in rabbits. (4222507)
1966
46
The role of PMN-leukocyte lysosomes in tissue injury, inflammation and hypersensitivity. I. The vascular changes and the role of PMN-leukocytes in the reversed passive Arthus reaction. (4225017)
1966
47
A PERMEABILITY FACTOR RELEASED FROM LEUKOCYTES AFTER PHAGOCYTOSIS OF IMMUNE COMPLEXES AND ITS POSSIBLE ROLE IN THE ARTHUS REACTION. (14206043)
1964
48
Electron microscopic and histochemical observatons on polymorphonuclear leucocytes in the reversed Arthus reaction. (14024587)
1962
49
Studies on the capillary permeability promoting action of serum. III. Significance of serum CPPA in the Arthus reaction and the Shwartzman phenomenon. (13291395)
1955
50
Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. (13037728)
1952

Genetic Variations for Arthus Reaction

Expression for genes affiliated with Arthus Reaction

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for genes affiliated with Arthus Reaction

Sources:
54Reactome, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 4Cell Signaling Technology, 30KEGG
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Compounds for genes affiliated with Arthus Reaction

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 60Tocris Bioscience, 24HMDB, 50PharmGKB, 2BitterDB
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Compounds related to Arthus Reaction according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1pge24510.1CXCL2
2bromelain4510.1ELANE, SELL
3estrogen4510.0CXCL2
4boswellic acids459.9ELANE, ALOX5
5mizolastine459.8ALOX5, HRH1
6cycloheximide459.8SELL, FCGR1A, CR1
7manoalide459.7ALOX5, ELANE
8cilomilast459.6ELANE, TNF
9pentoxifylline45 1110.5ELANE, SELL, TNF
10tenidap45 2910.5ELANE, ALOX5, TNF
11imidazole459.4ALOX5, HMOX1, HRH1
12endotoxin459.3SELL, HRH1, CXCL2
13rolipram45 60 2911.2TNF, SELL, ALOX5, ELANE
14anti-histamine459.2ALOX5, HRH1
15ndga459.2TNF, HRH1, ALOX5
16epinephrine45 11 2411.2HRH1, SELL, ALOX5, ELANE
17zymosan459.1TNF, CR1, FCGR1A, ELANE
18thalidomide45 50 60 1112.1SELL, MIF, TNF
19prednisolone45 29 1111.1SELL, FCGR1A, CR1, TNF
20prostacyclin459.0TNF, HMOX1, ALOX5, ELANE
21norepinephrine45 11 2411.0ELANE, SELL, HMOX1, HRH1, MIF
22curcumin459.0TNF, MIF, HMOX1, ALOX5
23superoxide45 249.9TNF, HMOX1, FCGR1A, SELL, ELANE
24aspirin45 50 29 2411.9HRH1, HMOX1, SELL, ALOX5, ELANE
25herbimycin a45 609.8TNF, MIF, FCGR1A, SELL, ALOX5
26manganese superoxide458.8TNF, CXCL2, HMOX1
27genistein45 29 60 2 11 2413.8TNF, MIF, FCGR1A, SELL, ALOX5
28n-formylmethionyl-leucylphenylalanine458.7TNF, CR1, SELL, ALOX5, ELANE
29leukotriene b445 60 2410.7TNF, CR1, SELL, ALOX5, ELANE
30h2o2458.7MIF, CXCL2, FCGR1A, SELL, ALOX5
31indomethacin45 60 29 1111.6TNF, HRH1, HMOX1, SELL, ALOX5
32histamine45 29 2410.6TNF, HRH1, HMOX1, SELL, ALOX5
33fibrinogen458.5ELANE, FCGR1A, CXCL2, TNF
34fmlp458.4TNF, CR1, FCGR1A, SELL, ALOX5, ELANE
35rantes458.4TNF, CD46, CXCL2, HRH1, SELL
36n acetylcysteine458.4TNF, CXCL2, HMOX1, ALOX5
37prostaglandin458.4ALOX5, HRH1, CXCL2, TNF
38retinoic acid45 249.3TNF, CR1, MIF, HMOX1, SELL, ELANE
39cyclosporin a45 29 6010.2TNF, CR1, CD46, HRH1, HMOX1, ELANE
40lactate458.1TNF, MIF, CXCL2, HMOX1, SELL, ELANE
41serine458.0TNF, MIF, CD46, CXCL2, FCGR1A, ALOX5
42sb 20358045 608.9TNF, MIF, CXCL2, HMOX1, SELL, ALOX5
43vegf457.9TNF, MIF, CXCL2, HMOX1, SELL, ALOX5
44tyrosine457.8CR1, MIF, CD46, CXCL2, FCGR1A, LAT
45oxygen45 248.6TNF, CR1, CXCL2, HMOX1, FCGR1A, SELL
46lipid457.6TNF, MIF, CXCL2, HRH1, FCGR1A, LAT
47nitric oxide45 11 249.3TNF, CR1, MIF, CD46, CXCL2, HRH1
48arachidonic acid45 29 11 2410.2TNF, CR1, MIF, CXCL2, HRH1, FCGR1A
49calcium45 50 11 2410.2CR1, MIF, CD46, CXCL2, HRH1, FCGR1A
50dexamethasone45 50 29 119.8TNF, MIF, CD46, CXCL2, HRH1, HMOX1

GO Terms for genes affiliated with Arthus Reaction

Sources:
16Gene Ontology
See all sources

Cellular components related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:0058878.3CR1, CD46, HRH1, SELL, TNF
2cell surfaceGO:0099868.1ELANE, CD46, MIF, CR1, TNF

Biological processes related to Arthus Reaction according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7TNF, MIF
2positive regulation of interleukin-8 biosynthetic processGO:0454169.6ELANE, TNF
3positive regulation of chemokine biosynthetic processGO:0450809.5HMOX1, TNF
4positive regulation of cytokine secretionGO:0507159.5MIF, TNF
5negative regulation of growth of symbiont in hostGO:0441309.5TNF, ELANE
6positive regulation of MAP kinase activityGO:0434069.4ELANE, MIF, TNF
7regulation of complement activationGO:0304499.4CD46, CR1
8positive regulation of smooth muscle cell proliferationGO:0486619.4ELANE, HMOX1, TNF
9innate immune responseGO:0450878.8LAT, FCGR1A, CD46, MIF, CR1
10inflammatory responseGO:0069548.2TNF, MIF, CXCL2, HRH1

Molecular functions related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020209.3ELANE, SELL, TNF

Products for genes affiliated with Arthus Reaction

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Arthus Reaction

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet