MCID: ART006
MIFTS: 37

Arthus Reaction malady

Categories: Immune diseases

Aliases & Classifications for Arthus Reaction

Aliases & Descriptions for Arthus Reaction:

Name: Arthus Reaction 12 52 42 14 69
Arthus Type Urticaria 12
Arthus Phenomenon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1556
ICD10 33 T78.41
ICD9CM 35 995.21
MeSH 42 D001183
NCIt 47 C34400
SNOMED-CT 64 29548007 402413008
UMLS 69 C0003907

Summaries for Arthus Reaction

MalaCards based summary : Arthus Reaction, also known as arthus type urticaria, is related to chromophobe adenoma and tick paralysis. An important gene associated with Arthus Reaction is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. Affiliated tissues include skin, neutrophil and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 71 In immunology, the Arthus reaction (/ˌɑːrˈtuːs/, /ˌɑːrˈtjuːs/) is a type of local type III... more...

Related Diseases for Arthus Reaction

Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
id Related Disease Score Top Affiliating Genes
1 chromophobe adenoma 10.3 ICAM1 SELL
2 tick paralysis 10.3 ICAM1 SELL
3 hypotrichosis-lymphedema-telangiectasia-renal defect syndrome 10.2 SELL TNF
4 phlegmonous dacryocystitis 10.2 ICAM1 SELL
5 hypotrichosis 4 10.2 ICAM1 TNF
6 uveitis 10.2 ICAM1 TNF
7 right ventricle hypoplasia 10.2 ICAM1 TNF
8 dermatomycosis 10.2 ICAM1 TNF
9 ulcerative proctitis 10.2 ALOX5 TNF
10 neurotic disorder 10.2 ICAM1 TNF
11 perrault syndrome 10.2 ICAM1 SELL
12 grix blankenship peterson syndrome 10.2 SELL TNF
13 venezuelan hemorrhagic fever 10.2 ICAM1 TNF
14 conduct disorder 10.2 ICAM1 TNF
15 craniopharyngioma 10.2 ICAM1 SELL
16 central cord syndrome 10.2 ICAM1 NOS2
17 subacute glomerulonephritis 10.2 ELANE ICAM1
18 radial defect robin sequence 10.2 ELANE TNF
19 hemangioma of orbit 10.2 ELANE TNF
20 idiopathic hypertrophic pachymeningitis 10.2 NOS2 TNF
21 tetanus 10.2 ELANE TNF
22 omsk hemorrhagic fever 10.2 ELANE SELL
23 amyotrophic lateral sclerosis type 14 10.1 NOS2 TNF
24 xerophthalmia 10.1 ICAM1 SELL
25 epimerase deficiency galactosemia 10.1 NOS2 TNF
26 oral cavity cancer 10.1 ICAM1 TNF
27 pulpitis 10.1 NOS2 TNF
28 acquired thrombocytopenia 10.1 NOS2 TNF
29 mycoplasmal pneumonia 10.1 HMOX1 TNF
30 ectodermal dysplasia bartalos type 10.1 NOS2 TNF
31 autoimmune-related retinopathy and optic neuropathy 10.1 ALOX5 ICAM1 TNF
32 erb-duchenne and dejerine-klumpke palsies 10.1 ICAM1 TNF
33 powassan encephalitis 10.1 ICAM1 TNF
34 geniculate ganglionitis 10.1 CR1 ICAM1 TNF
35 hyperuricemia, pulmonary hypertension, renal failure, and alkalosis 10.0 ELANE SELL TNF
36 pyelonephritis 10.0 ICAM1 NOS2 TNF
37 microscopic breast papilloma 10.0 ICAM1 NOS2 TNF
38 acute chest syndrome 10.0 ELANE ICAM1 TNF
39 pemphigus 10.0 CD46 CR1
40 collagenous colitis 10.0 ICAM1 NOS2 TNF
41 microcephaly 10.0 ICAM1 TNF
42 juvenile amyotrophic lateral sclerosis with dementia 10.0 CD46 TNF
43 spontaneous ocular nystagmus 10.0 ALOX5 ELANE TNF
44 advanced sleep phase syndrome, familial, 1 10.0 ICAM1 NOS2 TNF
45 strawberry gallbladder 10.0 ALOX5 ICAM1 SELL TNF
46 mucinous ovarian cystadenoma 9.9 HMOX1 ICAM1 NOS2
47 zellweger syndrome 9.9 HMOX1 NOS2 TNF
48 retinitis pigmentosa 51 9.9 ELANE HMOX1 TNF
49 vasculitis 9.9
50 eating disorder 9.9 ELANE ICAM1 SELL TNF

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to Arthus Reaction

Symptoms & Phenotypes for Arthus Reaction

MGI Mouse Phenotypes related to Arthus Reaction:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.8 ALOX5 CD46 HMOX1 ICAM1 NOS2 SELL
2 hematopoietic system MP:0005397 9.7 ALOX5 ELANE HMOX1 ICAM1 NOS2 SELL
3 immune system MP:0005387 9.5 ELANE HMOX1 ICAM1 NOS2 SELL TNF
4 neoplasm MP:0002006 9.02 ELANE ICAM1 NOS2 SELL TNF

Drugs & Therapeutics for Arthus Reaction

Search Clinical Trials , NIH Clinical Center for Arthus Reaction

Cochrane evidence based reviews: arthus reaction

Genetic Tests for Arthus Reaction

Anatomical Context for Arthus Reaction

MalaCards organs/tissues related to Arthus Reaction:

39
Skin, Neutrophil, Testes, Lung, Skeletal Muscle, Eye, Tongue

Publications for Arthus Reaction

Articles related to Arthus Reaction:

(show top 50) (show all 158)
id Title Authors Year
1
Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction. ( 27753135 )
2016
2
Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction. ( 24269785 )
2014
3
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. ( 23096126 )
2013
4
Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. ( 23800055 )
2013
5
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). ( 23511749 )
2013
6
Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. ( 23381473 )
2013
7
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction. ( 22784785 )
2012
8
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. ( 20008131 )
2010
9
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. ( 19389931 )
2009
10
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. ( 19188484 )
2009
11
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. ( 19513373 )
2008
12
Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide. ( 18505425 )
2008
13
Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction. ( 17299025 )
2007
14
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. ( 15728518 )
2005
15
Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. ( 14745115 )
2004
16
Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production. ( 15517609 )
2004
17
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. ( 12753427 )
2003
18
Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration. ( 11918584 )
2002
19
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. ( 11884469 )
2002
20
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. ( 12379763 )
2002
21
Transcription factor decoy oligodeoxynucleotides to nuclear factor-kappaB inhibit reverse passive Arthus reaction in rat. ( 11692225 )
2001
22
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. ( 11238587 )
2001
23
Arthus reaction to recombinant hepatitis B virus vaccine. ( 11512098 )
2001
24
Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea. ( 11316727 )
2001
25
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. ( 10623857 )
2000
26
A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. ( 10843715 )
2000
27
The Arthus reaction in rodents: species-specific requirement of complement. ( 10605043 )
2000
28
Contribution of B(2) receptors for bradykinin in arthus reaction-induced plasma extravasation in wild-type or B(2) transgenic knockout mice. ( 10780980 )
2000
29
On the role of complement and Fc gamma-receptors in the Arthus reaction. ( 10698344 )
1999
30
Roles of endothelins and their receptors in immune complex-induced/polymorphonuclear-mediated lung injury (reversed passive arthus reaction) in CD-1 mice. ( 9918750 )
1998
31
Streptococcal and staphylococcal superantigen-induced lymphocytic arteritis in a local type experimental model: comparison with acute vasculitis in the Arthus reaction. ( 9452132 )
1998
32
Nitric oxide inhibits neutrophil infiltration in the reverse passive arthus reaction in rat skin. ( 9826072 )
1998
33
P-selectin requirement for neutrophil accumulation and injury in the direct passive Arthus reaction. ( 9649192 )
1998
34
In vivo inflammatory response to a prototypic B cell superantigen: elicitation of an Arthus reaction by staphylococcal protein A. ( 9605120 )
1998
35
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. ( 9151106 )
1997
36
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. ( 9278109 )
1997
37
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. ( 9331774 )
1997
38
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. ( 9271590 )
1997
39
ICAM-1 mediates leukocyte-endothelium adhesive interactions in the reversed passive Arthus reaction. ( 8604010 )
1996
40
The role of CD11/CD18 integrins in the reverse passive Arthus reaction in rat dermal tissue. ( 8603998 )
1996
41
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. ( 8769481 )
1996
42
A dominant role for mast cell Fc receptors in the Arthus reaction. ( 8885871 )
1996
43
Role of P-selectin in the early stage of the Arthus reaction. ( 8886860 )
1996
44
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. ( 8548405 )
1995
45
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. ( 8066448 )
1994
46
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. ( 8301139 )
1994
47
Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators. ( 7889293 )
1994
48
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. ( 8242264 )
1993
49
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. ( 8228810 )
1993
50
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. ( 1388318 )
1992

Variations for Arthus Reaction

Expression for Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for Arthus Reaction

Pathways related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 21)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 ALOX5 CD46 CR1 ELANE HMOX1 ICAM1
2
Show member pathways
13.04 ALOX5 HMOX1 ICAM1 NOS2 TNF
3 12.23 ALOX5 CD46 HMOX1 TNF
4
Show member pathways
12.06 ALOX5 ICAM1 TNF
5 11.95 CR1 NOS2 TNF
6
Show member pathways
11.83 ALOX5 CR1 NOS2 TNF
7 11.81 HMOX1 ICAM1 TNF
8 11.71 ICAM1 NOS2 TNF
9
Show member pathways
11.38 ICAM1 NOS2 TNF
10 11.29 ICAM1 TNF
11 11.27 NOS2 TNF
12 11.23 CR1 ICAM1 TNF
13 11.18 ELANE ICAM1 TNF
14 11.17 ELANE SELL
15 11.14 ICAM1 NOS2
16 11.11 ICAM1 TNF
17 11.1 HMOX1 TNF
18 11.1 CR1 ICAM1 NOS2 TNF
19 11.08 ALOX5 HMOX1 ICAM1 NOS2 TNF
20 10.79 HMOX1 TNF
21 10.68 ICAM1 TNF

GO Terms for Arthus Reaction

Cellular components related to Arthus Reaction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.55 ALOX5 ELANE HMOX1 ICAM1 TNF
2 external side of plasma membrane GO:0009897 9.43 ICAM1 SELL TNF
3 integral component of plasma membrane GO:0005887 9.35 CD46 CR1 ICAM1 SELL TNF
4 cell surface GO:0009986 9.1 CD46 CR1 ELANE ICAM1 SELL TNF

Biological processes related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.78 ALOX5 CR1 ELANE SELL
2 defense response to bacterium GO:0042742 9.72 ELANE NOS2 TNF
3 response to lipopolysaccharide GO:0032496 9.71 ELANE ICAM1 NOS2
4 negative regulation of gene expression GO:0010629 9.69 CD46 NOS2 TNF
5 response to hypoxia GO:0001666 9.67 HMOX1 ICAM1 NOS2
6 cellular response to lipopolysaccharide GO:0071222 9.61 ICAM1 NOS2 TNF
7 intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 9.58 HMOX1 TNF
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.57 ICAM1 TNF
9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902042 9.56 HMOX1 ICAM1
10 positive regulation of vasodilation GO:0045909 9.52 HMOX1 NOS2
11 viral entry into host cell GO:0046718 9.5 CD46 CR1 ICAM1
12 negative regulation of growth of symbiont in host GO:0044130 9.46 ELANE TNF
13 positive regulation of chemokine biosynthetic process GO:0045080 9.4 HMOX1 TNF
14 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.37 ELANE TNF
15 positive regulation of smooth muscle cell proliferation GO:0048661 9.33 ELANE HMOX1 TNF
16 acute inflammatory response to antigenic stimulus GO:0002438 9.26 ELANE ICAM1
17 leukocyte migration GO:0050900 9.26 ELANE ICAM1 SELL TNF
18 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 8.62 ICAM1 TNF

Molecular functions related to Arthus Reaction according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 9.13 ELANE SELL TNF
2 virus receptor activity GO:0001618 8.8 CD46 CR1 ICAM1

Sources for Arthus Reaction

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