MCID: ART006
MIFTS: 52

Arthus Reaction malady

Skin diseases, Immune diseases categories
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Summaries for Arthus Reaction

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Wikipedia:65 In immunology, the Arthus reaction (/??r?tu?s/, /??r?tju?s/) is a type of local type III... more...

MalaCards based summary: Arthus Reaction, also known as arthus type urticaria, is related to vasculitis and arthritis. An important gene associated with Arthus Reaction is SELL (selectin L), and among its related pathways are Cell adhesion Cell matrix glycoconjugates and Complement Pathway. The compounds bromelain and boswellic acids have been mentioned in the context of this disorder. Affiliated tissues include skin, neutrophil and testes, and related mouse phenotypes are liver/biliary system and tumorigenesis.

Aliases & Classifications for Arthus Reaction

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT, 27ICD9CM
See all sources

Arthus Reaction, Aliases & Descriptions:

Name: Arthus Reaction 8 44 62
Arthus Type Urticaria 8 62
 
Arthus Phenomenon 8 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Immune diseases


External Ids:

Disease Ontology8 DOID:1556
MeSH34 D001183
SNOMED-CT57 29548007, 402413008
NCIt39 C34400
ICD9CM27 995.21

Related Diseases for Arthus Reaction

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Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 90)
idRelated DiseaseScoreTop Affiliating Genes
1vasculitis30.6ELANE, SELL, CD46, TNF
2arthritis30.6SELL, TNF
3peritonitis30.0CR1, ALOX5, CXCL2, TNF
4glomerulonephritis29.7CR1, ALOX5, MIF, ELANE, CD46
5asthma29.1SELL, HRH1, ALOX5, CR1, ELANE, TNF
6pneumonia29.0TNF, CR1, SELL, CXCL2, ELANE, HRH1
7cryptococcosis10.5SELL
8conjunctivitis10.4HRH1
9bronchopulmonary dysplasia10.4SELL, ELANE
10extrinsic allergic alveolitis10.3SELL, ELANE
11kawasaki disease10.3ELANE, SELL
12hepatitis10.3
13hepatitis b10.3
14thrombocytopenia10.3
15keratitis10.3MIF, CXCL2
16chorioamnionitis10.3ELANE, TNF
17respiratory failure10.3ALOX5, ELANE
18pulmonary sarcoidosis10.2TNF, SELL
19behcet's disease10.2TNF, SELL
20pulmonary emphysema10.2ELANE, HMOX1
21allergic rhinitis10.2HRH1, ALOX5
22periodontal disease10.2TNF, ELANE
23angioedema10.2HRH1, ALOX5
24aneurysm10.2ELANE, ALOX5, SELL
25periodontitis10.2ELANE, TNF
26graft versus host disease10.2SELL, TNF
27non-suppurative otitis media10.2SELL, ALOX5
28gastritis10.2CXCL2, MIF, CD46
29sickle cell disease10.2HMOX1, SELL
30urticaria10.2HRH1, ALOX5
31diphtheria10.1
32shwartzman phenomenon10.1
33encephalitis10.1
34eosinophilia10.1
35pertussis10.1
36pleurisy10.1
37thyroiditis10.1
38afibrinogenemia10.1CR1, CD46
39bacterial meningitis10.1CXCL2, CR1
40adult respiratory distress syndrome10.1TNF, ELANE, ALOX5
41cork-handlers' disease10.1ELANE, HMOX1
42allergic asthma10.1SELL, HRH1, ALOX5
43vascular disease10.1ELANE, HMOX1, CD46
44skin disease10.1HRH1, SELL, TNF
45pulmonary fibrosis10.0ELANE, ALOX5, HMOX1
46arthropathy10.0ALOX5, TNF
47insulin resistance10.0MIF, TNF, SELL
48psoriasis10.0ELANE, ALOX5, TNF
49systemic scleroderma10.0ALOX5, MIF, SELL, CD46
50osteoarthritis10.0TNF, ALOX5, CXCL2

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to arthus reaction

Symptoms for Arthus Reaction

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Drugs & Therapeutics for Arthus Reaction

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Drug clinical trials:

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Genetic Tests for Arthus Reaction

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Anatomical Context for Arthus Reaction

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MalaCards organs/tissues related to Arthus Reaction:

32
Skin, Neutrophil, Testes, Skeletal muscle, Lung, Eye, Thyroid, B cells, Tongue

Animal Models for Arthus Reaction or affiliated genes

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MGI Mouse Phenotypes related to Arthus Reaction:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.6HRH1, HMOX1, SELL, TNF
2MP:00020068.6TNF, SELL, ELANE, MIF
3MP:00053977.5HRH1, TNF, SELL, ELANE, MIF, ALOX5
4MP:00053877.5TNF, SELL, ELANE, MIF, ALOX5, HMOX1
5MP:00053767.4TNF, SELL, ELANE, MIF, ALOX5, HMOX1

Publications for Arthus Reaction

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Articles related to Arthus Reaction:

(show top 50)    (show all 156)
idTitleAuthorsYear
1
Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction. (24269785)
2014
2
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). (23511749)
2013
3
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. (19389931)
2009
4
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. (19188484)
2009
5
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. (19513373)
2008
6
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. (12753427)
2003
7
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. (10623857)
2000
8
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. (9331774)
1997
9
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. (9151106)
1997
10
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. (9278109)
1997
11
Role of P-selectin in the early stage of the Arthus reaction. (8886860)
1996
12
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. (8548405)
1995
13
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. (8301139)
1994
14
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. (8066448)
1994
15
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. (8242264)
1993
16
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. (8228810)
1993
17
Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. (1388318)
1992
18
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. (1330163)
1992
19
Serotonin metabolism in the arthus reaction. (2136904)
1990
20
Biological and immunological properties of Sugi basic protein-pullulan conjugate. II. Is the reduced ability to elicit the Arthus reaction based on the poor activation of complement by immune complex consisting of anti-Sugi basic protein and Sugi basic protein-pullulan? (2138137)
1990
21
The Arthus reaction in domestic cats. (2969157)
1988
22
Effect of chlorpromazine on the development of experimental glomerulonephritis and Arthus reaction. (2968048)
1988
23
Impaired histamine metabolism in the Arthus reaction induced in guinea-pig skin. (3159351)
1985
24
Effects of PGF2 alpha on the active Arthus reaction in rat and rabbit tongues. (3161844)
1985
25
Immune complexes and inflammation. A study of the activity of anti-inflammatory drugs in the reverse passive arthus reaction in the rat. (6221727)
1983
26
Modification of two models of Arthus reaction in the rat by various drugs. (6460508)
1982
27
The effects of anti-inflammatory and other agents on the rat dermal arthus reaction. (6122238)
1982
28
Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes. (6455972)
1981
29
Transient immune deposits in the papillary dermis and in the epidermis. A light-microscopical study on the experimental Arthus reaction. (6449910)
1980
30
The Arthus reaction in rats, a possible test for anti-inflammatory and antiheumatic drugs. (157676)
1979
31
The effect of sulphinpyrazone and other drugs on the platelet response during the acute phase of the active Arthus reaction in guinea pigs. (158844)
1979
32
Lepromin and the Arthus reaction. (147247)
1977
33
The effect of shock on the inflammatory response. A reevaluation of the role of platelets in the active arthus reaction. (122800)
1975
34
Ultrastructural evidence for lack of tissue damage in a local immune complex reaction: a study of a mild passive Arthus reaction. (125484)
1975
35
Gastrointestinal ulcer--arthus reaction. (4273310)
1974
36
The early changes in the Arthus reaction in the rabbit oral mucosa. (4280437)
1974
37
The requirement for platelets in the active Arthus reaction. (4258952)
1971
38
Effects of neutrophils on tissues. Experiments on the Arthus reaction, the flare phenomenon, and post-phagocytic release of lysosomal enzymes. (4243806)
1969
39
Adrenal medullary hormones and phenothiazine: effects on the Arthus reaction in adult rabbits. (4389807)
1969
40
Leukoegresin: a factor from rabbit skin associated with leucocytic emigration in the Arthus reaction. (4234575)
1968
41
The Arthus reaction to Candida albicans in asthma patients. (4237283)
1968
42
Inhibitory effect of large doses of histamine on the passive Arthus reaction. (4225450)
1967
43
Hyperacute encephalitis resembling the Arthus-reaction. (4239964)
1966
44
ARTHUS REACTION IN THE ORAL CAVITY OF LABORATORY ANIMALS. (14248775)
1965
45
Fluorescent protein tracer studies in allergic reactions. I. The fate of fluorescent antigen in active and passive Arthus reaction in the guinea-pig skin. (14482093)
1961
46
Prevention by intravenous injection of antigen and antibody of passive Arthus reaction to unrelated immune system. (13675297)
1959
47
Observations on the histology of the Arthus reaction and its relation to other known types of skin hypersensitivity. (13142698)
1954
48
Quantitative study of Arthus reaction and of cutaneous anaphylaxis induced passively in the rat. (13037728)
1952
49
Effect of 17-hydroxy-11-dehydrocorticosterone (compound E) and of ACTH on arthus reaction and antibody formation in the rabbit. (14781192)
1950
50
Effect of salicylate and tripelennamine hydrochloride (pyribenzamine) on the Arthus reaction and on bacterial allergic reactions. (18900017)
1947

Variations for Arthus Reaction

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Expression for genes affiliated with Arthus Reaction

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Expression patterns in normal tissues for genes affiliated with Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for genes affiliated with Arthus Reaction

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Pathways related to Arthus Reaction according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.9ELANE, SELL
2
Show member pathways
Immune response Alternative complement pathway60
Immune response Lectin Induced complement pathway60
Immune response Classic complement pathway60
9.6CD46, CR1
39.5TNF, ELANE
4
Show member pathways
9.5ELANE, TNF
59.5MIF, TNF
69.4HMOX1, TNF
79.3CR1, TNF
89.3ALOX5, HMOX1, CD46
99.0TNF, CXCL2
10
Show member pathways
8.9CR1, ALOX5, TNF
118.7MIF, CXCL2, TNF
128.5CR1, CXCL2, TNF
13
Show member pathways
8.2ALOX5, MIF, CXCL2, TNF

Compounds for genes affiliated with Arthus Reaction

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Compounds related to Arthus Reaction according to GeneCards/GeneDecks:

(show top 50)    (show all 110)
idCompoundScoreTop Affiliating Genes
1bromelain4410.1ELANE, SELL
2boswellic acids4410.0ELANE, ALOX5
3mizolastine449.9HRH1, ALOX5
4manoalide449.9ALOX5, ELANE
5tenidap44 2810.5ALOX5, ELANE, TNF
6pentoxifylline44 1110.5SELL, ELANE, TNF
7anti-histamine449.4ALOX5, HRH1
8thalidomide44 50 61 1112.4MIF, SELL, TNF
9imidazole449.4HRH1, HMOX1, ALOX5
10zymosan449.4TNF, CR1, ELANE
11alpha tocopherol449.3HMOX1, ELANE, ALOX5
12ndga449.3HRH1, ALOX5, TNF
13epinephrine44 24 1111.3SELL, ALOX5, ELANE, HRH1
14rolipram44 61 2811.2ALOX5, SELL, TNF, ELANE
15paraffin449.1CD46, MIF, SELL, CR1
16herbimycin a44 6110.1ALOX5, MIF, TNF, SELL
17prednisolone44 28 1111.0SELL, CR1, TNF
18prostacyclin449.0ELANE, HMOX1, TNF, ALOX5
19curcumin449.0HMOX1, ALOX5, TNF, MIF
20genistein44 28 61 2 24 1113.9ALOX5, MIF, SELL, TNF
21norepinephrine44 24 1110.9HMOX1, MIF, ELANE, HRH1, SELL
22aspirin44 50 28 2411.9HRH1, ELANE, SELL, HMOX1, ALOX5
23manganese superoxide448.9TNF, CXCL2, HMOX1
24atorvastatin44 50 28 24 1112.8TNF, HMOX1, SELL
25n-formylmethionyl-leucylphenylalanine448.7ELANE, CR1, ALOX5, SELL, TNF
26alanine448.7CD46, HRH1, SELL, MIF, HMOX1
27leukotriene b444 61 2410.7TNF, SELL, ELANE, ALOX5, CR1
28fmlp448.7TNF, CR1, SELL, ELANE, ALOX5
29sp 60012544 619.6HMOX1, CXCL2, TNF
30superoxide44 249.6TNF, SELL, CR1, HMOX1, ELANE
31indomethacin44 28 61 1111.6SELL, TNF, ALOX5, HMOX1, HRH1
32histamine44 28 2410.6TNF, SELL, ALOX5, HRH1, HMOX1
33n acetylcysteine448.5TNF, CXCL2, ALOX5, HMOX1
34prostaglandin448.4CXCL2, TNF, ALOX5, HRH1
35estrogen448.3CXCL2, ELANE, HMOX1, ALOX5, MIF
36retinoic acid44 249.3HMOX1, MIF, ELANE, CR1, TNF, SELL
37cycloheximide448.2HMOX1, CR1, ALOX5, SELL, TNF, CD46
38cyclosporin a44 28 6110.1TNF, ELANE, CR1, HMOX1, CD46, HRH1
39lactate448.0MIF, SELL, HMOX1, TNF, CXCL2, ELANE
40rantes447.9TNF, SELL, CXCL2, MIF, CD46, HRH1
41sb 20358044 618.9ALOX5, HMOX1, TNF, SELL, CXCL2, MIF
42vegf447.9SELL, ALOX5, MIF, HMOX1, CXCL2, TNF
43serine447.7CD46, TNF, MIF, ALOX5, SELL, ELANE
44arachidonic acid44 28 24 1110.6HRH1, CR1, TNF, CXCL2, MIF, ALOX5
45h2o2447.6TNF, HMOX1, SELL, ALOX5, MIF, ELANE
46endotoxin447.4HRH1, SELL, CXCL2, ELANE, MIF, CR1
47nitric oxide44 24 119.2MIF, CXCL2, TNF, CR1, HMOX1, CD46
48pge2447.1MIF, HRH1, HMOX1, TNF, SELL, CXCL2
49oxygen44 248.1TNF, SELL, ELANE, MIF, CXCL2, ALOX5
50dexamethasone44 50 28 1110.1ALOX5, HMOX1, TNF, SELL, CXCL2, CD46

GO Terms for genes affiliated with Arthus Reaction

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Cellular components related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell surfaceGO:0099868.2CD46, CR1, MIF, ELANE, TNF
2integral component of plasma membraneGO:0058878.2HRH1, CD46, CR1, SELL, TNF
3extracellular spaceGO:0056157.5TNF, CXCL2, MIF, ALOX5, HMOX1

Biological processes related to Arthus Reaction according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine (C-X-C motif) ligand 2 productionGO:20003439.7MIF, TNF
2positive regulation of interleukin-8 biosynthetic processGO:0454169.7TNF, ELANE
3regulation of complement activationGO:0304499.7CD46, CR1
4negative regulation of growth of symbiont in hostGO:0441309.6ELANE, TNF
5positive regulation of chemokine biosynthetic processGO:0450809.5TNF, HMOX1
6complement activation, classical pathwayGO:0069589.5CD46, CR1
7positive regulation of cytokine secretionGO:0507159.5TNF, MIF
8positive regulation of peptidyl-serine phosphorylationGO:0331389.5MIF, TNF
9positive regulation of MAP kinase activityGO:0434069.4TNF, ELANE, MIF
10positive regulation of smooth muscle cell proliferationGO:0486619.3HMOX1, ELANE, TNF
11negative regulation of gene expressionGO:0106299.3CD46, MIF, TNF
12intrinsic apoptotic signaling pathway in response to DNA damageGO:0086309.1HMOX1, TNF
13inflammatory responseGO:0069548.4TNF, CXCL2, MIF, HRH1

Molecular functions related to Arthus Reaction according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protease bindingGO:0020208.9ELANE, SELL, TNF
2protein bindingGO:0055157.3SELL, CXCL2, ELANE, MIF, ALOX5, CD46

Products for genes affiliated with Arthus Reaction

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Sources for Arthus Reaction

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet