MCID: ART006
MIFTS: 39

Arthus Reaction

Categories: Immune diseases

Aliases & Classifications for Arthus Reaction

MalaCards integrated aliases for Arthus Reaction:

Name: Arthus Reaction 12 51 41 14 69
Arthus Type Urticaria 12
Arthus Phenomenon 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1556
ICD10 32 T78.41
ICD9CM 34 995.21
MeSH 41 D001183
NCIt 46 C34400
SNOMED-CT 64 29548007 402413008
UMLS 69 C0003907

Summaries for Arthus Reaction

MalaCards based summary : Arthus Reaction, also known as arthus type urticaria, is related to shwartzman phenomenon and vasculitis. An important gene associated with Arthus Reaction is SELL (Selectin L), and among its related pathways/superpathways are Innate Immune System and Selenium Micronutrient Network. Affiliated tissues include skin, neutrophil and testes, and related phenotypes are cardiovascular system and hematopoietic system

Wikipedia : 72 In immunology, the Arthus reaction (/ˌɑːrˈtuːs/, /ˌɑːrˈtjuːs/) is a type of local type III... more...

Related Diseases for Arthus Reaction

Diseases related to Arthus Reaction via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 shwartzman phenomenon 30.3 ICAM1 SELL
2 vasculitis 29.7 ELANE ICAM1 SELL TNF
3 glomerulonephritis 29.6 CR1 ICAM1 MIF
4 pleurisy 29.5 ALOX5 ICAM1 SELL TNF
5 asthma 28.9 ALOX5 ELANE ICAM1 SELL TNF
6 toxicodendron dermatitis 10.4 ICAM1 SELL
7 plummer's disease 10.4 ICAM1 SELL
8 leukostasis 10.4 ICAM1 SELL
9 retinitis pigmentosa 60 10.4 SELL TNF
10 chronic venous insufficiency 10.4 ICAM1 SELL
11 granulocytopenia 10.4 SELL TNF
12 actinic prurigo 10.3 ICAM1 TNF
13 poliomyelitis 10.3 ICAM1 TNF
14 erythema multiforme 10.3 ICAM1 TNF
15 venous insufficiency 10.3 ICAM1 SELL
16 lichen disease 10.3 ICAM1 TNF
17 cytomegalovirus infection 10.3 ICAM1 TNF
18 tuberculous meningitis 10.3 ALOX5 TNF
19 plasmodium vivax malaria 10.3 ICAM1 TNF
20 critical illness polyneuropathy 10.3 ICAM1 TNF
21 periodontosis 10.3 ELANE SELL
22 lepromatous leprosy 10.3 ICAM1 TNF
23 rapidly progressive glomerulonephritis 10.3 ELANE ICAM1
24 pustular psoriasis 10.2 ELANE TNF
25 farmer's lung 10.2 ELANE TNF
26 erysipelas 10.2 ELANE TNF
27 cutaneous lupus erythematosus 10.2 ICAM1 TNF
28 anoxia 10.2 ICAM1 NOS2
29 oligoarticular juvenile idiopathic arthritis 10.2 MIF TNF
30 allergic hypersensitivity disease 10.2
31 pustulosis palmaris et plantaris 10.2 ELANE TNF
32 primary progressive multiple sclerosis 10.2 ICAM1 TNF
33 bronchopulmonary dysplasia 10.2 ELANE SELL
34 nose disease 10.2 ICAM1 TNF
35 tympanosclerosis 10.2 NOS2 TNF
36 idiopathic achalasia 10.1 NOS2 TNF
37 adult-onset still's disease 10.1 MIF TNF
38 dystrophinopathies 10.1 NOS2 TNF
39 crohn's colitis 10.1 NOS2 TNF
40 acute respiratory distress syndrome 10.1 ELANE TNF
41 eales disease 10.1 NOS2 TNF
42 periventricular leukomalacia 10.1 NOS2 TNF
43 mycetoma 10.1 CR1 NOS2
44 leukomalacia 10.1 NOS2 TNF
45 pulmonary disease, chronic obstructive 10.0 ELANE TNF
46 kawasaki disease 10.0 ELANE SELL TNF
47 rheumatoid vasculitis 10.0 ICAM1 MIF TNF
48 respiratory system disease 10.0 ELANE ICAM1 TNF
49 hepatopulmonary syndrome 10.0 NOS2 TNF
50 sarcoidosis 1 10.0 ICAM1 MIF TNF

Graphical network of the top 20 diseases related to Arthus Reaction:



Diseases related to Arthus Reaction

Symptoms & Phenotypes for Arthus Reaction

MGI Mouse Phenotypes related to Arthus Reaction:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.73 NOS2 SELL TNF ALOX5 CD46 ICAM1
2 hematopoietic system MP:0005397 9.7 NOS2 SELL TNF ALOX5 ELANE ICAM1
3 immune system MP:0005387 9.5 MIF NOS2 SELL TNF ALOX5 ELANE
4 neoplasm MP:0002006 9.1 NOS2 SELL TNF ELANE ICAM1 MIF

Drugs & Therapeutics for Arthus Reaction

Search Clinical Trials , NIH Clinical Center for Arthus Reaction

Cochrane evidence based reviews: arthus reaction

Genetic Tests for Arthus Reaction

Anatomical Context for Arthus Reaction

MalaCards organs/tissues related to Arthus Reaction:

38
Skin, Neutrophil, Testes, Skeletal Muscle, Lung, Tongue, Eye

Publications for Arthus Reaction

Articles related to Arthus Reaction:

(show top 50) (show all 158)
# Title Authors Year
1
Anti-TWEAK monoclonal antibodies reduce vascular damage and leucocyte infiltration in a mouse model of cutaneous reverse passive Arthus reaction. ( 27753135 )
2016
2
Diagnosis of Mesobuthus eupeus envenomation by skin test: Reverse passive Arthus reaction. ( 24269785 )
2014
3
Paeoniflorin suppresses vascular damage and the expression of E-selectin and ICAM-1 in a mouse model of cutaneous Arthus reaction. ( 23800055 )
2013
4
Metabolomic investigation of Arthus reaction in a rat model using proton nuclear magnetic resonance (1H NMR) spectroscopy and rapid resolution liquid chromatography (RRLC). ( 23511749 )
2013
5
Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. ( 23096126 )
2013
6
Exogenous application of hydrogen sulfide donor attenuates inflammatory reactions through the L-selectin-involved pathway in the cutaneous reverse passive Arthus reaction. ( 23381473 )
2013
7
Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction. ( 22784785 )
2012
8
Platelets control leukocyte recruitment in a murine model of cutaneous arthus reaction. ( 20008131 )
2010
9
Migration inhibitory factor (MIF) released by macrophages upon recognition of immune complexes is critical to inflammation in Arthus reaction. ( 19188484 )
2009
10
Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. ( 19389931 )
2009
11
Involvement of gaseous low molecular monoxides in the cutaneous reverse passive Arthus reaction: cytoprotective action of carbon monoxide. ( 18505425 )
2008
12
Effects of cholinotropic and cytostatic drugs on the development of Arthus reaction. ( 19513373 )
2008
13
Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction. ( 17299025 )
2007
14
Macrophages induce the inflammatory response in the pulmonary Arthus reaction through G alpha i2 activation that controls C5aR and Fc receptor cooperation. ( 15728518 )
2005
15
Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production. ( 15517609 )
2004
16
Effect of nicotine-induced corticosterone elevation on nitric oxide production in the passive skin arthus reaction in rats. ( 14745115 )
2004
17
Nicotine-induced inflammatory decreasing effect on passive skin arthus reaction in paraventricular nucleus-lesioned wistar rats. ( 12753427 )
2003
18
New functions of neutrophils in the arthus reaction: expression of tissue factor, the clotting initiator, and fibrinolysis by elastase. ( 12379763 )
2002
19
The cutaneous reverse Arthus reaction requires intercellular adhesion molecule 1 and L-selectin expression. ( 11884469 )
2002
20
Arthus reaction to lepirudin, a new recombinant hirudin, and delayed-type hypersensitivity to several heparins and heparinoids, with tolerance to its intravenous administration. ( 11918584 )
2002
21
Apoptosis mediates decrease in cellularity during the regression of Arthus reaction in cornea. ( 11316727 )
2001
22
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. ( 11238587 )
2001
23
Transcription factor decoy oligodeoxynucleotides to nuclear factor-kappaB inhibit reverse passive Arthus reaction in rat. ( 11692225 )
2001
24
Arthus reaction to recombinant hepatitis B virus vaccine. ( 11512098 )
2001
25
The Arthus reaction in rodents: species-specific requirement of complement. ( 10605043 )
2000
26
A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. ( 10623857 )
2000
27
Contribution of B(2) receptors for bradykinin in arthus reaction-induced plasma extravasation in wild-type or B(2) transgenic knockout mice. ( 10780980 )
2000
28
A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. ( 10843715 )
2000
29
On the role of complement and Fc gamma-receptors in the Arthus reaction. ( 10698344 )
1999
30
In vivo inflammatory response to a prototypic B cell superantigen: elicitation of an Arthus reaction by staphylococcal protein A. ( 9605120 )
1998
31
P-selectin requirement for neutrophil accumulation and injury in the direct passive Arthus reaction. ( 9649192 )
1998
32
Streptococcal and staphylococcal superantigen-induced lymphocytic arteritis in a local type experimental model: comparison with acute vasculitis in the Arthus reaction. ( 9452132 )
1998
33
Nitric oxide inhibits neutrophil infiltration in the reverse passive arthus reaction in rat skin. ( 9826072 )
1998
34
Roles of endothelins and their receptors in immune complex-induced/polymorphonuclear-mediated lung injury (reversed passive arthus reaction) in CD-1 mice. ( 9918750 )
1998
35
Light and electron microscopic examination of skeletal muscles in the reversed passive Arthus reaction. ( 9278109 )
1997
36
Histochemical investigations of the skeletal muscle fibres during the reversed passive Arthus reaction in guinea pigs. ( 9151106 )
1997
37
Impaired inflammatory responses in the reverse arthus reaction through genetic deletion of the C5a receptor. ( 9271590 )
1997
38
Erythrogenic toxin-induced arteritis in a rabbit ear model. Comparison with Arthus reaction angiitis. ( 9331774 )
1997
39
A dominant role for mast cell Fc receptors in the Arthus reaction. ( 8885871 )
1996
40
Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. ( 8769481 )
1996
41
The role of CD11/CD18 integrins in the reverse passive Arthus reaction in rat dermal tissue. ( 8603998 )
1996
42
ICAM-1 mediates leukocyte-endothelium adhesive interactions in the reversed passive Arthus reaction. ( 8604010 )
1996
43
Role of P-selectin in the early stage of the Arthus reaction. ( 8886860 )
1996
44
The role of ICAM-1 in the reverse passive Arthus reaction induced pleurisy in the rat. ( 8548405 )
1995
45
Studies on the mechanisms involved in the inflammatory response in a reversed passive Arthus reaction in guinea-pig skin: contribution of neutrophils and endogenous mediators. ( 7889293 )
1994
46
Neutrophil elicitation in the reverse passive Arthus reaction. Complement-dependent and -independent mast cell involvement. ( 8301139 )
1994
47
Fc receptors initiate the Arthus reaction: redefining the inflammatory cascade. ( 8066448 )
1994
48
Role of oxygen radicals and arachidonic acid metabolites in the reverse passive Arthus reaction and carrageenin paw oedema in the rat. ( 8242264 )
1993
49
Recombinant soluble human Fc gamma RII: production, characterization, and inhibition of the Arthus reaction. ( 8228810 )
1993
50
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. ( 1330163 )
1992

Variations for Arthus Reaction

Expression for Arthus Reaction

Search GEO for disease gene expression data for Arthus Reaction.

Pathways for Arthus Reaction

GO Terms for Arthus Reaction

Cellular components related to Arthus Reaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.35 CD46 CR1 ICAM1 SELL TNF
2 external side of plasma membrane GO:0009897 9.33 ICAM1 SELL TNF
3 cell surface GO:0009986 9.17 CD46 CR1 ELANE ICAM1 MIF SELL

Biological processes related to Arthus Reaction according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.75 MIF NOS2 TNF
2 defense response to bacterium GO:0042742 9.74 ELANE NOS2 TNF
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.71 ICAM1 MIF TNF
4 response to lipopolysaccharide GO:0032496 9.7 ELANE ICAM1 NOS2
5 cellular response to lipopolysaccharide GO:0071222 9.65 ICAM1 NOS2 TNF
6 viral entry into host cell GO:0046718 9.63 CD46 CR1 ICAM1
7 positive regulation of nitric oxide biosynthetic process GO:0045429 9.58 ICAM1 TNF
8 cell aging GO:0007569 9.56 ICAM1 MIF
9 positive regulation of cytokine secretion GO:0050715 9.55 MIF TNF
10 leukocyte tethering or rolling GO:0050901 9.51 SELL TNF
11 negative regulation of growth of symbiont in host GO:0044130 9.49 ELANE TNF
12 negative regulation of gene expression GO:0010629 9.46 CD46 MIF NOS2 TNF
13 acute inflammatory response to antigenic stimulus GO:0002438 9.43 ELANE ICAM1
14 positive regulation of MAP kinase activity GO:0043406 9.43 ELANE MIF TNF
15 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.4 ELANE TNF
16 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.37 ICAM1 TNF
17 neutrophil degranulation GO:0043312 9.35 ALOX5 CR1 ELANE MIF SELL
18 positive regulation of chemokine (C-X-C motif) ligand 2 production GO:2000343 9.32 MIF TNF
19 leukocyte migration GO:0050900 9.02 ELANE ICAM1 MIF SELL TNF

Molecular functions related to Arthus Reaction according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 virus receptor activity GO:0001618 9.13 CD46 CR1 ICAM1
2 protease binding GO:0002020 8.92 ELANE MIF SELL TNF

Sources for Arthus Reaction

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