MCID: ASB002
MIFTS: 24

Asbestos-Related Lung Carcinoma

Categories: Cancer diseases, Respiratory diseases

Aliases & Classifications for Asbestos-Related Lung Carcinoma

MalaCards integrated aliases for Asbestos-Related Lung Carcinoma:

Name: Asbestos-Related Lung Carcinoma 12 14

Classifications:



External Ids:

Disease Ontology 12 DOID:7596
NCIt 47 C27925
UMLS 69 C1332337

Summaries for Asbestos-Related Lung Carcinoma

MalaCards based summary : Asbestos-Related Lung Carcinoma is related to childhood infratentorial neoplasm and glomus vagale tumor. An important gene associated with Asbestos-Related Lung Carcinoma is PIK3R3 (Phosphoinositide-3-Kinase Regulatory Subunit 3), and among its related pathways/superpathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. Affiliated tissues include lung, and related phenotypes are Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance and Decreased viability with paclitaxel

Related Diseases for Asbestos-Related Lung Carcinoma

Diseases related to Asbestos-Related Lung Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 childhood infratentorial neoplasm 9.8 EGFR PDGFB
2 glomus vagale tumor 9.1 EGFR PDGFB PRKCA
3 stomach disease 6.6 CDC42 DEGS1 EGFR IGF1 PDGFB PIK3R3

Symptoms & Phenotypes for Asbestos-Related Lung Carcinoma

GenomeRNAi Phenotypes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.35 CDC42 EGFR PIK3R3 PRKCA PRKX
2 Decreased viability with paclitaxel GR00179-A-1 8.92 EGFR IGF1
3 Decreased viability with paclitaxel GR00179-A-2 8.92 IGF1
4 Decreased viability with paclitaxel GR00179-A-3 8.92 EGFR

MGI Mouse Phenotypes related to Asbestos-Related Lung Carcinoma:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.35 DEGS1 EGFR IGF1 PDGFB PRKCA
2 muscle MP:0005369 9.02 PRKCA DEGS1 EGFR IGF1 PDGFB

Drugs & Therapeutics for Asbestos-Related Lung Carcinoma

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Comparison of the Ultra-low-dose Veo Algorithm With the Gold Standard Filtered Back Projection for Detecting Pulmonary Asbestos-related Conditions Completed NCT01955018 Phase 4
2 Early Detection of Lung Cancer and Mesothelioma in Workers Exposed to Asbestos Unknown status NCT01719068

Search NIH Clinical Center for Asbestos-Related Lung Carcinoma

Genetic Tests for Asbestos-Related Lung Carcinoma

Anatomical Context for Asbestos-Related Lung Carcinoma

MalaCards organs/tissues related to Asbestos-Related Lung Carcinoma:

39
Lung

Publications for Asbestos-Related Lung Carcinoma

Variations for Asbestos-Related Lung Carcinoma

Cosmic variations for Asbestos-Related Lung Carcinoma:

9 (show top 50) (show all 78)
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA Conf
1 COSM95548 XRCC6 lung,NS,carcinoma,undifferentiated carcinoma c.1159A>C p.I387L 4
2 COSM95544 XRCC1 lung,NS,carcinoma,undifferentiated carcinoma c.1207A>G p.M403V 4
3 COSM95531 WNT8A lung,NS,carcinoma,undifferentiated carcinoma c.368G>C p.G123A 4
4 COSM95521 WNT10B lung,NS,carcinoma,undifferentiated carcinoma c.1006A>C p.K336Q 4
5 COSM95485 USP5 lung,NS,carcinoma,undifferentiated carcinoma c.755C>T p.T252I 4
6 COSM95476 USP38 lung,NS,carcinoma,undifferentiated carcinoma c.994G>C p.A332P 4
7 COSM96265 USP32 lung,NS,carcinoma,undifferentiated carcinoma c.192T>A p.I64I 4
8 COSM94158 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.2691A>T p.Q897H 4
9 COSM94159 UBR5 lung,NS,carcinoma,undifferentiated carcinoma c.1555A>G p.S519G 4
10 COSM95420 TYK2 lung,NS,carcinoma,undifferentiated carcinoma c.3560G>T p.C1187F 4
11 COSM95390 TRAF5 lung,NS,carcinoma,undifferentiated carcinoma c.302G>C p.R101T 4
12 COSM10768 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.535C>T p.H179Y 4
13 COSM10742 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.578A>G p.H193R 4
14 COSM43750 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.811G>T p.E271* 4
15 COSM43753 TP53 lung,NS,carcinoma,undifferentiated carcinoma c.560-1G>A p.? 4
16 COSM95367 TLR5 lung,NS,carcinoma,undifferentiated carcinoma c.1A>G p.M1V 4
17 COSM95359 TLR4 lung,NS,carcinoma,undifferentiated carcinoma c.337C>A p.P113T 4
18 COSM95356 TLR2 lung,NS,carcinoma,undifferentiated carcinoma c.1169A>G p.Q390R 4
19 COSM95347 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.1087C>T p.P363S 4
20 COSM95342 TLN1 lung,NS,carcinoma,undifferentiated carcinoma c.5624C>T p.S1875L 4
21 COSM95340 TLE4 lung,NS,carcinoma,undifferentiated carcinoma c.859A>C p.K287Q 4
22 COSM95334 TIAM1 lung,NS,carcinoma,undifferentiated carcinoma c.3718G>C p.E1240Q 4
23 COSM95292 STK38 lung,NS,carcinoma,undifferentiated carcinoma c.407C>G p.A136G 4
24 COSM95282 STAT1 lung,NS,carcinoma,undifferentiated carcinoma c.2042A>T p.Y681F 4
25 COSM95276 SPRY2 lung,NS,carcinoma,undifferentiated carcinoma c.652T>C p.C218R 4
26 COSM95270 SPOP lung,NS,carcinoma,undifferentiated carcinoma c.570A>C p.L190F 4
27 COSM94327 RNF145 lung,NS,carcinoma,undifferentiated carcinoma c.647G>A p.G216E 4
28 COSM95658 RIN1 lung,NS,carcinoma,undifferentiated carcinoma c.1210C>T p.Q404* 4
29 COSM95187 RICTOR lung,NS,carcinoma,undifferentiated carcinoma c.1711C>A p.H571N 4
30 COSM96136 PLCG1 lung,NS,carcinoma,undifferentiated carcinoma c.3366C>T p.D1122D 4
31 COSM95013 PKHD1 lung,NS,carcinoma,undifferentiated carcinoma c.2753C>A p.P918Q 4
32 COSM94967 PIK3C2A lung,NS,carcinoma,undifferentiated carcinoma c.3240A>T p.E1080D 4
33 COSM94958 PDIA4 lung,NS,carcinoma,undifferentiated carcinoma c.1735G>T p.V579F 4
34 COSM96110 PAX6 lung,NS,carcinoma,undifferentiated carcinoma c.372G>T p.G124G 4
35 COSM94918 PARP1 lung,NS,carcinoma,undifferentiated carcinoma c.790C>G p.L264V 4
36 COSM94897 P2RY1 lung,NS,carcinoma,undifferentiated carcinoma c.238A>G p.M80V 4
37 COSM94878 NTSR1 lung,NS,carcinoma,undifferentiated carcinoma c.808G>T p.A270S 4
38 COSM94867 NRG3 lung,NS,carcinoma,undifferentiated carcinoma c.490G>T p.A164S 4
39 COSM94848 NOTCH2 lung,NS,carcinoma,undifferentiated carcinoma c.5637G>A p.M1879I 4
40 COSM95032 MED1 lung,NS,carcinoma,undifferentiated carcinoma c.2444A>G p.H815R 4
41 COSM94685 MC5R lung,NS,carcinoma,undifferentiated carcinoma c.458T>C p.I153T 4
42 COSM94681 MAX lung,NS,carcinoma,undifferentiated carcinoma c.368A>G p.Y123C 4
43 COSM94657 MAML1 lung,NS,carcinoma,undifferentiated carcinoma c.2605C>A p.Q869K 4
44 COSM94614 LMTK2 lung,NS,carcinoma,undifferentiated carcinoma c.2931C>A p.S977R 4
45 COSM95625 LHCGR lung,NS,carcinoma,undifferentiated carcinoma c.1660C>T p.R554* 4
46 COSM520 KRAS lung,NS,carcinoma,undifferentiated carcinoma c.35G>T p.G12V 4
47 COSM516 KRAS lung,NS,carcinoma,undifferentiated carcinoma c.34G>T p.G12C 4
48 COSM95622 KIF27 lung,NS,carcinoma,undifferentiated carcinoma c.620C>G p.S207* 4
49 COSM94573 KEAP1 lung,NS,carcinoma,undifferentiated carcinoma c.1000T>C p.Y334H 4
50 COSM94797 KAT6B lung,NS,carcinoma,undifferentiated carcinoma c.649A>G p.S217G 4

Expression for Asbestos-Related Lung Carcinoma

Search GEO for disease gene expression data for Asbestos-Related Lung Carcinoma.

Pathways for Asbestos-Related Lung Carcinoma

Pathways related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show top 50) (show all 81)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.68 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
2
Show member pathways
13.68 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
3
Show member pathways
13.5 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
4
Show member pathways
13.4 EGFR IGF1 PDGFB PIK3R3 PRKCA
5
Show member pathways
13.38 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
6
Show member pathways
13.35 CDC42 EGFR PDGFB PIK3R3 PRKCA
7
Show member pathways
13.23 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
8
Show member pathways
13.18 EGFR IGF1 PDGFB PIK3R3 PRKCA
9
Show member pathways
13.18 CDC42 IGF1 PDGFB PIK3R3 PRKCA
10
Show member pathways
13.13 EGFR IGF1 PDGFB PIK3R3 PRKCA
11
Show member pathways
13.09 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
12
Show member pathways
13.07 CDC42 EGFR IGF1 PIK3R3 PRKCA
13
Show member pathways
12.96 CDC42 EGFR PDGFB PRKCA
14
Show member pathways
12.9 EGFR IGF1 PDGFB PIK3R3 PRKCA
15
Show member pathways
12.87 CDC42 IGF1 PIK3R3 PRKCA
16
Show member pathways
12.82 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
17
Show member pathways
12.8 CDC42 PDGFB PIK3R3 PRKCA
18
Show member pathways
12.79 CDC42 EGFR IGF1 PIK3R3
19
Show member pathways
12.78 CDC42 EGFR PIK3R3 PRKCA
20
Show member pathways
12.7 CDC42 EGFR IGF1 PIK3R3 PRKCA
21
Show member pathways
12.68 CDC42 PDGFB PIK3R3 PRKCA
22
Show member pathways
12.61 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
23 12.6 CDC42 EGFR PDGFB PRKCA
24
Show member pathways
12.59 CDC42 EGFR IGF1 PIK3R3 PRKCA
25
Show member pathways
12.54 EGFR PDGFB PIK3R3 PRKCA
26 12.51 CDC42 EGFR PDGFB PIK3R3
27
Show member pathways
12.51 EGFR IGF1 PDGFB PIK3R3 PRKCA
28
Show member pathways
12.45 CDC42 EGFR IGF1 PIK3R3
29
Show member pathways
12.42 CDC42 EGFR PRKCA
30 12.42 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
31
Show member pathways
12.41 EGFR PIK3R3 PRKCA
32
Show member pathways
12.41 EGFR IGF1 PDGFB PIK3R3 PRKCA
33
Show member pathways
12.4 CDC42 PIK3R3 PRKCA
34 12.4 EGFR PDGFB PRKCA
35
Show member pathways
12.39 EGFR IGF1 PIK3R3 PRKCA
36
Show member pathways
12.37 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
37
Show member pathways
12.36 CDC42 EGFR PRKCA
38
Show member pathways
12.36 PDGFB PIK3R3 PRKCA
39
Show member pathways
12.33 CDC42 PIK3R3 PRKCA
40
Show member pathways
12.33 EGFR PIK3R3 PRKCA
41
Show member pathways
12.3 CDC42 PIK3R3 PRKCA
42
Show member pathways
12.29 EGFR PDGFB PIK3R3 PRKCA
43
Show member pathways
12.28 CDC42 PIK3R3 PRKCA
44
Show member pathways
12.28 CDC42 EGFR PIK3R3 PRKCA
45
Show member pathways
12.27 EGFR PIK3R3 PRKCA
46
Show member pathways
12.27 EGFR PDGFB PIK3R3 PRKCA
47 12.23 CDC42 EGFR IGF1 PDGFB PIK3R3 PRKCA
48
Show member pathways
12.22 EGFR PIK3R3 PRKCA
49
Show member pathways
12.18 EGFR IGF1 PIK3R3 PRKCA
50
Show member pathways
12.14 CDC42 EGFR PRKCA

GO Terms for Asbestos-Related Lung Carcinoma

Biological processes related to Asbestos-Related Lung Carcinoma according to GeneCards Suite gene sharing:

(show all 18)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.7 EGFR PDGFB PRKCA
2 peptidyl-serine phosphorylation GO:0018105 9.61 PDGFB PRKCA PRKX
3 ERBB2 signaling pathway GO:0038128 9.58 EGFR PRKCA
4 phosphatidylinositol-mediated signaling GO:0048015 9.58 EGFR IGF1 PDGFB
5 negative regulation of epidermal growth factor receptor signaling pathway GO:0042059 9.57 CDC42 EGFR
6 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.56 CDC42 PDGFB
7 protein phosphorylation GO:0006468 9.56 EGFR PDGFB PRKCA PRKX
8 activation of protein kinase B activity GO:0032148 9.55 IGF1 PDGFB
9 positive regulation of mitotic nuclear division GO:0045840 9.54 IGF1 PDGFB
10 positive regulation of MAPK cascade GO:0043410 9.54 CDC42 IGF1 PDGFB
11 embryonic placenta development GO:0001892 9.51 EGFR PDGFB
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.5 EGFR IGF1 PDGFB
13 positive regulation of blood vessel endothelial cell migration GO:0043536 9.49 PDGFB PRKCA
14 positive regulation of cardiac muscle hypertrophy GO:0010613 9.48 IGF1 PRKCA
15 positive regulation of smooth muscle cell migration GO:0014911 9.46 IGF1 PDGFB
16 positive regulation of fibroblast proliferation GO:0048146 9.33 EGFR IGF1 PDGFB
17 positive regulation of cell migration GO:0030335 9.26 EGFR IGF1 PDGFB PRKCA
18 positive regulation of DNA replication GO:0045740 8.92 CDC42 EGFR IGF1 PDGFB

Sources for Asbestos-Related Lung Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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