MCID: ASB001
MIFTS: 51

Asbestosis malady

Rare diseases, Respiratory diseases categories
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Summaries for Asbestosis

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Wikipedia:65 Asbestosis is a chronic inflammatory and fibrotic medical condition affecting the parenchymal tissue of... more...

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to lung cancer and adenocarcinoma. An important gene associated with Asbestosis is GSTT1 (glutathione S-transferase theta 1), and among its related pathways are Chemical carcinogenesis and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds drugs for treatment of tuberculosis and methylchloride have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and neutrophil, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:8 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

Aliases & Classifications for Asbestosis

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Asbestosis, Aliases & Descriptions:

Name: Asbestosis 8 42 10 44 62
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 42
 
Pulmonary Fibrosis - from Asbestos Exposure 42
Asbestosis Nos 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


External Ids:

Disease Ontology8 DOID:10320
NCIt39 C84573
MeSH34 D001195
ICD9CM27 501

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.2GSTM1, GSTT1, OGG1
2adenocarcinoma30.2GSTM1, GSTT1, OGG1
3stomach cancer30.2GSTM1, GSTT1, OGG1
4pneumonia30.0GSTM1, SOD3
5lung adenocarcinoma30.0OGG1, GSTT1, GSTM1
6non-hodgkin lymphoma30.0GSTM1, GSTT1, OGG1
7chronic obstructive pulmonary disease29.8GSTT1, GSTM1, SOD3
8silicosis10.6
9pulmonary function10.4
10pneumoconiosis10.4
11pulmonary fibrosis10.4
12idiopathic pulmonary fibrosis10.3
13tuberculosis10.3
14brain cancer10.3GSTT1, GSTM1
15senile cataract10.3GSTM1, GSTT1
16open-angle glaucoma10.3GSTT1, GSTM1
17acute myeloid leukemia, adult10.3GSTT1, GSTM1
18leukoplakia10.3GSTM1, GSTT1
19laryngeal benign neoplasm10.3GSTT1, GSTM1
20aplastic anemia10.3GSTT1, GSTM1
21laryngeal squamous cell carcinoma10.3GSTT1, GSTM1
22acute lymphoblastic leukemia, childhood10.2GSTM1, GSTT1
23bladder carcinoma10.2GSTM1, GSTT1
24basal cell carcinoma10.2GSTT1, GSTM1
25oral cancer10.2GSTT1, GSTM1
26nasopharynx carcinoma10.2GSTT1, GSTM1
27transitional cell carcinoma10.2GSTT1, GSTM1
28xeroderma pigmentosum10.2OGG1, GSTT1
29thyroid hurthle cell carcinoma10.2GSTT1, GSTM1
30pulmonary tuberculosis10.2
31malignant mesothelioma10.2
32gastric adenocarcinoma10.2GSTT1, GSTM1
33myelodysplastic syndromes10.2GSTT1, GSTM1
34endometriosis10.1GSTT1, GSTM1
35berylliosis10.1
36laryngitis10.1
37peritonitis10.1
38asbestos intoxication10.1
39non-small cell lung carcinoma10.1OGG1, GSTM1
40squamous cell carcinoma of the head and neck10.0OGG1, GSTT1, GSTM1
41cervical cancer10.0GSTT1, GSTM1
42lung small cell carcinoma10.0OGG1, GSTT1, GSTM1
43acute leukemia10.0OGG1, GSTT1, GSTM1
44adenoma10.0OGG1, GSTT1, GSTM1
45colonic benign neoplasm10.0GSTM1, GSTT1, OGG1
46liver cancer10.0OGG1, GSTT1, GSTM1
47acute myocardial infarction10.0SOD3, GSTM1
48alzheimer's disease10.0GSTM1, GSTT1, OGG1
49colorectal cancer10.0GSTM1, GSTT1, OGG1
50tongue squamous cell carcinoma9.9OGG1, GSTT1, GSTM1

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Drug clinical trials:

Search ClinicalTrials for Asbestosis

Search NIH Clinical Center for Asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

32
Lung, Testes, Neutrophil, Bone marrow, Bone, Colon, Liver, Testis, Nk cells, T cells

Animal Models for Asbestosis or affiliated genes

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MGI Mouse Phenotypes related to Asbestosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7OGG1, KIF5A, GSTT1, GSTM1, SOD3

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 495)
idTitleAuthorsYear
1
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
2
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
3
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
4
Asbestosis and mesothelioma among British asbestos workers (1971-2005). (20957726)
2010
5
Serum growth factors in asbestosis patients. (19283526)
2009
6
Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases. (19523203)
2009
7
Pleural plaques and asbestosis: dose- and time-response relationships based on HRCT data. (19129281)
2009
8
Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease. (10543275)
1999
9
New technologies in diagnosing occupational asbestosis. (10376357)
1998
10
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
11
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
12
Clinical predictors of mortality from asbestosis in the North American Insulator Cohort, 1981 to 1991. (9230732)
1997
13
Professor Matthew Stewart: asbestosis research 1929-1934. (9327084)
1997
14
Does asbestos or asbestosis cause carcinoma of the lung? (7892835)
1994
15
Asbestos fiber analysis in seven asbestosis cases. (8117151)
1994
16
Gamma/delta T-lymphocytes in advanced pulmonary asbestosis. (8140322)
1993
17
Computed tomography in the early detection of asbestosis. (8398855)
1993
18
Bronchoalveolar lavage and 99mTc-DTPA clearance as prognostic factors in asbestos workers with and without asbestosis. (8209056)
1993
19
Current imaging of asbestosis. (2701517)
1989
20
Roentgenographic underestimation of early asbestosis. (2707080)
1989
21
Validation of clinical criteria for diagnosing asbestosis in asbestos-cement workers. (2489415)
1989
22
Asbestosis occurring after brief inhalational exposure: usefulness of bronchoalveolar lavage in diagnosis. (2538140)
1989
23
Asbestosis among electricians. (3262731)
1988
24
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
25
The association of carcinoma, tuberculosis, asbestosis, and fibrosing alveolitis of the lung: report of a case and review of the literature. (3679907)
1987
26
Immunogenetic factors as determinants of asbestosis. (3108592)
1987
27
Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. (3706896)
1986
28
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
29
Diagnosis of asbestosis. Clinical, radiological and lung function data in 42 patients. (6527564)
1984
30
Asbestos related diseases without asbestosis. (6223683)
1983
31
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
32
Incipient cases of asbestosis in a Kenyan factory. (6671435)
1983
33
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
34
Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure. (7249746)
1981
35
The development of asbestosis. (18748527)
1980
36
Asbestosis in the industries of the Barcelona area. (7342762)
1980
37
Asbestosis: a study of dose-response relationships in an asbestos textile factory. (465379)
1979
38
Computed tomography in pulmonary asbestosis. (436371)
1979
39
Absence of synergism between exposure to asbestos and cigarette smoking in asbestosis. (464386)
1979
40
Elimination of asbestosis. (651728)
1978
41
Asbestosis. (73933)
1977
42
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. (872451)
1977
43
Diagnosis of asbestosis by transbronchial biopsy. A method to facilitate demonstration of ferruginous bodies. (848793)
1977
44
A survey of patients diagnosed as having asbestosis. (135908)
1976
45
Proceedings: HL-A type and asbestosis. (1181698)
1975
46
Chest auscultation in the diagnosis of pulmonary asbestosis. (4693173)
1973
47
Asbestosis and neoplastic disorders of the hematopoietic system. (4984519)
1970
48
The radiology of asbestosis. (5798718)
1969
49
Mucociliary function in health, chronic obstructive airway disease, and asbestosis. (5781603)
1969
50
SILICO-ANTHRACOSIS PRESENTING CURIOUS BODIES SIMILAR TO THOSE IN ASBESTOSIS. (20776780)
1932

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Expression patterns in normal tissues for genes affiliated with Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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Pathways related to Asbestosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GSTT1, GSTM1
29.6GSTT1, GSTM1
3
Show member pathways
glutathione-mediated detoxification I37
glutathione redox reactions I37
glutathione redox reactions II37
4-hydroxy-2-nonenal detoxification37
Glutathione metabolism60
Glutathione metabolism37
9.6GSTM1, GSTT1
49.6GSTT1, GSTM1
59.3KIF5A, KIF18A
69.3KIF5A, KIF18A
79.3KIF5A, KIF18A

Compounds for genes affiliated with Asbestosis

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Sources:
50PharmGKB, 44Novoseek, 11DrugBank, 24HMDB
See all sources

Compounds related to Asbestosis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1drugs for treatment of tuberculosis5010.0GSTM1, GSTT1
2methylchloride4410.0GSTM1, GSTT1
3n-(2-hydroxyethyl)valine4410.0GSTM1, GSTT1
4trans,trans-muconic acid4410.0GSTT1, GSTM1
5ethambutol50 4411.0GSTT1, GSTM1
6s-phenylmercapturic acid4410.0GSTM1, GSTT1
7hema4410.0GSTT1, GSTM1
82-naphthol4410.0GSTT1, GSTM1
9styrene oxide4410.0GSTT1, GSTM1
10butadiene monoxide4410.0GSTM1, GSTT1
111,3-butadiene4410.0GSTT1, GSTM1
12cumene hydroperoxide4410.0GSTT1, GSTM1
13vinylchloride4410.0GSTM1, GSTT1
14pyrazinamide44 50 1112.0GSTT1, GSTM1
15streptomycin50 44 1112.0GSTT1, GSTM1
16arylamine4410.0GSTM1, GSTT1
17diepoxybutane4410.0GSTT1, GSTM1
18styrene4410.0GSTT1, GSTM1
19toluene4410.0GSTT1, GSTM1
20trichloroethylene449.9GSTM1, GSTT1
211-chloro-24-dinitrobenzene449.9GSTT1, GSTM1
22benzidine449.9GSTT1, GSTM1
23chi 2449.9GSTM1, GSTT1
244-Hydroxyestrone-2-S-glutathione249.9GSTM1, GSTT1
25Estrone-2,3-quinone249.9GSTT1, GSTM1
26Estrone-3,4-quinone249.9GSTT1, GSTM1
27S-(PGJ2)-glutathione249.9GSTT1, GSTM1
282-Hydroxyestrone-4-S-glutathione249.9GSTM1, GSTT1
29bpde449.9GSTT1, GSTM1
30noradrenochrome44 2410.8GSTT1, GSTM1
312-Hydroxyestrone-1-S-glutathione249.8GSTT1, GSTM1
32hydrochloric acid44 2410.8GSTM1, GSTT1
33adrenochrome44 2410.7GSTT1, GSTM1
34isoniazid44 50 1111.7GSTT1, GSTM1
35aflatoxin b144 2410.6GSTM1, GSTT1
36rifampin50 1110.6GSTT1, GSTM1
37ethylene oxide449.5OGG1, GSTT1, GSTM1
381-hydroxypyrene449.5OGG1, GSTT1, GSTM1
398-oxoguanine449.5GSTM1, GSTT1, OGG1
408-oxo-dg449.5GSTM1, GSTT1, OGG1
41cotinine44 2410.5OGG1, GSTT1, GSTM1
42benzene449.5GSTM1, GSTT1, OGG1
43rsai449.5GSTT1, GSTM1
44agarose449.5OGG1, GSTT1, GSTM1
45acetone449.3GSTT1, GSTM1
46manganese superoxide448.7OGG1, GSTT1, GSTM1, SOD3
47malondialdehyde448.7SOD3, GSTM1, GSTT1, OGG1
48folate448.7SOD3, GSTM1, GSTT1, OGG1
49ascorbic acid44 249.7OGG1, GSTT1, GSTM1, SOD3
50oxygen44 249.4OGG1, GSTT1, GSTM1, SOD3

GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinesin complexGO:0058719.3KIF5A, KIF18A
2cytosolGO:0058297.3KIF5A, KIF18A, GSTT1, GSTM1, SOD3

Biological processes related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:19016879.7GSTT1, GSTM1
2glutathione metabolic processGO:0067499.7GSTT1, GSTM1
3xenobiotic metabolic processGO:0068059.6GSTT1, GSTM1
4microtubule-based movementGO:0070189.3KIF5A, KIF18A
5antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.2KIF18A, KIF5A
6metabolic processGO:0081529.0KIF5A, KIF18A

Molecular functions related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:0043649.6GSTT1, GSTM1
2microtubule bindingGO:0080178.5OGG1, KIF5A, KIF18A

Products for genes affiliated with Asbestosis

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  • Antibodies
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Sources for Asbestosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet