Aliases & Classifications for Asbestosis

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Asbestosis, Aliases & Descriptions:

Name: Asbestosis 9 41 11 43 60
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 41
 
Pulmonary Fibrosis - from Asbestos Exposure 41
Asbestosis Nos 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases


External Ids:

Disease Ontology9 DOID:10320
MeSH33 D001195
ICD9CM27 501
NCIt38 C84573

Summaries for Asbestosis

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Wikipedia:63 Asbestosis is a chronic inflammatory and fibrotic medical condition affecting the parenchymal tissue of... more...

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to lung cancer and laryngeal carcinoma. An important gene associated with Asbestosis is GSTT1 (glutathione S-transferase theta 1), and among its related pathways are Chemical carcinogenesis and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds drugs for treatment of tuberculosis and methylchloride have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and neutrophil, and related mouse phenotype homeostasis/metabolism.

Disease Ontology:9 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.3OGG1, GSTM1
2laryngeal carcinoma30.3GSTT1, GSTM1
3adenocarcinoma30.3GSTM1, GSTT1, OGG1
4pneumonia30.1GSTM1, SOD3
5mesothelioma10.7
6silicosis10.6
7pulmonary function10.5
8pneumoconiosis10.4
9pulmonary fibrosis10.4
10tuberculosis10.3
11brain cancer10.3GSTT1, GSTM1
12senile cataract10.3GSTM1, GSTT1
13mismatch repair cancer syndrome10.3GSTT1, GSTM1
14open-angle glaucoma10.3GSTT1, GSTM1
15acute myeloid leukemia, adult10.3GSTT1, GSTM1
16leukoplakia10.2GSTM1, GSTT1
17aplastic anemia10.2GSTT1, GSTM1
18laryngeal squamous cell carcinoma10.2GSTT1, GSTM1
19acute lymphoblastic leukemia, childhood10.2GSTM1, GSTT1
20bladder cancer, somatic10.2GSTM1, GSTT1
21basal cell carcinoma10.2GSTT1, GSTM1
22oral cancer10.2GSTT1, GSTM1
23nasopharyngeal carcinoma10.2GSTT1, GSTM1
24transitional cell carcinoma10.2GSTT1, GSTM1
25xeroderma pigmentosum, variant type10.2OGG1, GSTT1
26thyroid cancer10.2GSTT1, GSTM1
27pulmonary tuberculosis10.2
28gastric adenocarcinoma10.2GSTT1, GSTM1
29myelodysplastic syndrome10.1GSTT1, GSTM1
30endometriosis10.1GSTT1, GSTM1
31berylliosis10.1
32laryngitis10.1
33peritonitis10.1
34stomach cancer10.1
35asbestos intoxication10.1
36nicotine dependence, protection against10.0OGG1, GSTT1, GSTM1
37squamous cell carcinoma, head and neck10.0OGG1, GSTT1, GSTM1
38cervical cancer, somatic10.0GSTT1, GSTM1
39lung cancer susceptibility 310.0OGG1, GSTT1, GSTM1
40small cell cancer of the lung, somatic10.0OGG1, GSTT1, GSTM1
41lymphoma, non-hodgkin10.0GSTM1, GSTT1, OGG1
42acute leukemia10.0OGG1, GSTT1, GSTM1
43adenoma10.0OGG1, GSTT1, GSTM1
44gastric cancer, somatic10.0GSTM1, GSTT1, OGG1
45hepatocellular carcinoma10.0OGG1, GSTT1, GSTM1
46acute myocardial infarction10.0SOD3, GSTM1
47alzheimer disease10.0GSTM1, GSTT1, OGG1
48colorectal cancer10.0GSTM1, GSTT1, OGG1
49systemic lupus erythematosus10.0
50insulin-like growth factor i10.0

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Drug clinical trials:

Search ClinicalTrials for Asbestosis

Search NIH Clinical Center for Asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

31
Lung, Testes, Neutrophil, Bone marrow, Bone, Colon, Liver, Testis, Nk cells, T cells

Animal Models for Asbestosis or affiliated genes

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MGI Mouse Phenotypes related to Asbestosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7OGG1, KIF5A, GSTT1, GSTM1, SOD3

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 502)
idTitleAuthorsYear
1
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
2
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
3
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
4
Asbestosis and mesothelioma among British asbestos workers (1971-2005). (20957726)
2010
5
Serum growth factors in asbestosis patients. (19283526)
2009
6
Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases. (19523203)
2009
7
Pleural plaques and asbestosis: dose- and time-response relationships based on HRCT data. (19129281)
2009
8
Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease. (10543275)
1999
9
New technologies in diagnosing occupational asbestosis. (10376357)
1998
10
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
11
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
12
Clinical predictors of mortality from asbestosis in the North American Insulator Cohort, 1981 to 1991. (9230732)
1997
13
Professor Matthew Stewart: asbestosis research 1929-1934. (9327084)
1997
14
Does asbestos or asbestosis cause carcinoma of the lung? (7892835)
1994
15
Asbestos fiber analysis in seven asbestosis cases. (8117151)
1994
16
Gamma/delta T-lymphocytes in advanced pulmonary asbestosis. (8140322)
1993
17
Computed tomography in the early detection of asbestosis. (8398855)
1993
18
Bronchoalveolar lavage and 99mTc-DTPA clearance as prognostic factors in asbestos workers with and without asbestosis. (8209056)
1993
19
Current imaging of asbestosis. (2701517)
1989
20
Roentgenographic underestimation of early asbestosis. (2707080)
1989
21
Validation of clinical criteria for diagnosing asbestosis in asbestos-cement workers. (2489415)
1989
22
Asbestosis occurring after brief inhalational exposure: usefulness of bronchoalveolar lavage in diagnosis. (2538140)
1989
23
Asbestosis among electricians. (3262731)
1988
24
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
25
The association of carcinoma, tuberculosis, asbestosis, and fibrosing alveolitis of the lung: report of a case and review of the literature. (3679907)
1987
26
Immunogenetic factors as determinants of asbestosis. (3108592)
1987
27
Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. (3706896)
1986
28
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
29
Diagnosis of asbestosis. Clinical, radiological and lung function data in 42 patients. (6527564)
1984
30
Asbestos related diseases without asbestosis. (6223683)
1983
31
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
32
Incipient cases of asbestosis in a Kenyan factory. (6671435)
1983
33
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
34
Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure. (7249746)
1981
35
The development of asbestosis. (18748527)
1980
36
Asbestosis in the industries of the Barcelona area. (7342762)
1980
37
Asbestosis: a study of dose-response relationships in an asbestos textile factory. (465379)
1979
38
Computed tomography in pulmonary asbestosis. (436371)
1979
39
Absence of synergism between exposure to asbestos and cigarette smoking in asbestosis. (464386)
1979
40
Elimination of asbestosis. (651728)
1978
41
Asbestosis. (73933)
1977
42
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. (872451)
1977
43
Diagnosis of asbestosis by transbronchial biopsy. A method to facilitate demonstration of ferruginous bodies. (848793)
1977
44
A survey of patients diagnosed as having asbestosis. (135908)
1976
45
Proceedings: HL-A type and asbestosis. (1181698)
1975
46
Chest auscultation in the diagnosis of pulmonary asbestosis. (4693173)
1973
47
Asbestosis and neoplastic disorders of the hematopoietic system. (4984519)
1970
48
The radiology of asbestosis. (5798718)
1969
49
Mucociliary function in health, chronic obstructive airway disease, and asbestosis. (5781603)
1969
50
SILICO-ANTHRACOSIS PRESENTING CURIOUS BODIES SIMILAR TO THOSE IN ASBESTOSIS. (20776780)
1932

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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Pathways related to Asbestosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GSTT1, GSTM1
29.6GSTT1, GSTM1
3
Show member pathways
glutathione-mediated detoxification I36
glutathione redox reactions I36
glutathione redox reactions II36
4-hydroxy-2-nonenal detoxification36
Glutathione metabolism58
Glutathione metabolism36
9.6GSTM1, GSTT1
49.6GSTT1, GSTM1
59.3KIF5A, KIF18A
69.3KIF5A, KIF18A
79.3KIF5A, KIF18A

Compounds for genes affiliated with Asbestosis

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Sources:
49PharmGKB, 43Novoseek, 12DrugBank, 24HMDB
See all sources

Compounds related to Asbestosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1drugs for treatment of tuberculosis4910.0GSTM1, GSTT1
2methylchloride4310.0GSTM1, GSTT1
3n-(2-hydroxyethyl)valine4310.0GSTM1, GSTT1
4trans,trans-muconic acid4310.0GSTT1, GSTM1
5ethambutol49 4311.0GSTT1, GSTM1
6s-phenylmercapturic acid4310.0GSTM1, GSTT1
7hema4310.0GSTT1, GSTM1
82-naphthol4310.0GSTT1, GSTM1
9styrene oxide4310.0GSTT1, GSTM1
10butadiene monoxide4310.0GSTM1, GSTT1
111,3-butadiene4310.0GSTT1, GSTM1
12cumene hydroperoxide4310.0GSTT1, GSTM1
13vinylchloride4310.0GSTM1, GSTT1
14pyrazinamide43 49 1212.0GSTT1, GSTM1
15streptomycin49 43 1212.0GSTT1, GSTM1
16arylamine4310.0GSTM1, GSTT1
17diepoxybutane4310.0GSTT1, GSTM1
18styrene4310.0GSTT1, GSTM1
19toluene4310.0GSTT1, GSTM1
20trichloroethylene439.9GSTM1, GSTT1
211-chloro-24-dinitrobenzene439.9GSTT1, GSTM1
22benzidine439.9GSTT1, GSTM1
23chi 2439.9GSTM1, GSTT1
244-Hydroxyestrone-2-S-glutathione249.9GSTM1, GSTT1
25Estrone-2,3-quinone249.9GSTT1, GSTM1
26Estrone-3,4-quinone249.9GSTT1, GSTM1
27S-(PGJ2)-glutathione249.9GSTT1, GSTM1
282-Hydroxyestrone-4-S-glutathione249.9GSTM1, GSTT1
29bpde439.9GSTT1, GSTM1
30noradrenochrome43 2410.8GSTT1, GSTM1
312-Hydroxyestrone-1-S-glutathione249.8GSTT1, GSTM1
32hydrochloric acid43 2410.8GSTM1, GSTT1
33adrenochrome43 2410.7GSTT1, GSTM1
34isoniazid43 49 1211.7GSTT1, GSTM1
35aflatoxin b143 2410.6GSTM1, GSTT1
36rifampin49 1210.6GSTT1, GSTM1
37ethylene oxide439.5OGG1, GSTT1, GSTM1
381-hydroxypyrene439.5OGG1, GSTT1, GSTM1
398-oxoguanine439.5GSTM1, GSTT1, OGG1
408-oxo-dg439.5GSTM1, GSTT1, OGG1
41cotinine43 2410.5OGG1, GSTT1, GSTM1
42benzene439.5GSTM1, GSTT1, OGG1
43rsai439.5GSTT1, GSTM1
44agarose439.5OGG1, GSTT1, GSTM1
45acetone439.3GSTT1, GSTM1
46manganese superoxide438.7OGG1, GSTT1, GSTM1, SOD3
47malondialdehyde438.7SOD3, GSTM1, GSTT1, OGG1
48folate438.7SOD3, GSTM1, GSTT1, OGG1
49ascorbic acid43 249.7OGG1, GSTT1, GSTM1, SOD3
50oxygen43 249.4OGG1, GSTT1, GSTM1, SOD3

GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1kinesin complexGO:00058719.3KIF5A, KIF18A
2cytosolGO:00058297.3KIF5A, KIF18A, GSTT1, GSTM1, SOD3

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:019016879.7GSTT1, GSTM1
2glutathione metabolic processGO:00067499.7GSTT1, GSTM1
3xenobiotic metabolic processGO:00068059.6GSTT1, GSTM1
4microtubule-based movementGO:00070189.3KIF5A, KIF18A
5antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:00198869.2KIF18A, KIF5A
6metabolic processGO:00081529.0KIF5A, KIF18A

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:00043649.6GSTT1, GSTM1
2microtubule bindingGO:00080178.5OGG1, KIF5A, KIF18A

Products for genes affiliated with Asbestosis

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Sources for Asbestosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet