MCID: ASB001
MIFTS: 42

Asbestosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

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Aliases & Descriptions for Asbestosis:

Name: Asbestosis 11 48 50 39 13 68
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 48
 
Pulmonary Fibrosis - from Asbestos Exposure 48

Classifications:



External Ids:

Disease Ontology11 DOID:10320
ICD1030 J61
ICD9CM32 501
MeSH39 D001195
NCIt45 C84573

Summaries for Asbestosis

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Wikipedia:71 Asbestosis is a chronic inflammatory and scarring disease affecting the tissue of the lungs. People with... more...

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to berylliosis and asbestos intoxication. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways are Oxidative Stress and Folate Metabolism. Affiliated tissues include lung, testes and neutrophil, and related mouse phenotype Synthetic lethal with paclitaxel.

Disease Ontology:11 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 75)
idRelated DiseaseScoreTop Affiliating Genes
1berylliosis26.1GSTM1, GSTP1, GSTT1, IL6, KIF18A, KIF5A
2asbestos intoxication11.0
3interstitial lung disease10.8
4oral pharyngeal disorders10.6GSTM1, GSTT1
5levic stefanovic nikolic syndrome10.5GSTM1, GSTT1
6emery-dreifuss muscular dystrophy, dominant type10.5GSTM1, GSTT1
7ulcerative stomatitis10.5GSTM1, GSTT1
8lung cancer10.4
9myasthenia gravis, limb-girdle10.4GSTM1, GSTT1
10orbital cyst10.4GSTM1, GSTT1
11hallucinogen abuse10.4SOD2, SOD3
12cavernous hemangioma of colon10.4GSTM1, GSTT1
13renal artery disease10.3GSTM1, IL6
14chorioretinitis10.2GSTT1, IL6
15silicosis10.2
16sweat gland cancer10.2IL6, SERPINA1
17mast syndrome10.2SOD2, SOD3
18gender identity disorder10.1GSTM1, GSTT1, IL6
19cervix carcinoma10.1GSTM1, GSTT1, IL6
20conventional leiomyosarcoma10.1IL6, MPO
21pulmonary fibrosis10.1
22anti-basement membrane glomerulonephritis10.1IL6, MPO
23pneumoconiosis10.1
24oral lichen planus10.0GSTM1, GSTP1, GSTT1
25cervical cancer, somatic10.0GSTM1, GSTP1, GSTT1
26adenocarcinoma10.0
27bardet-biedl syndrome 89.9IL6, SERPINA1
28pleural disease9.9
29tuberculosis9.9
30hypocalciuric hypercalcemia, type i9.9GSTM1, GSTT1, IL6
31pneumonia9.9
32abdominal chemodectomas with cutaneous angiolipomas9.8IL6, MPO, SERPINA1
33lymphopenia9.8IL6, MPO, SERPINA1
34laryngeal tuberculosis9.8IL6, MPO, SERPINA1
35perianal skin paget's disease9.8IL6, MPO, SERPINA1
36fungal meningitis9.8MPO, THBD
37macroglobulinemia, waldenstrom 19.8IL6, MPO, SERPINA1
38pulmonary tuberculosis9.8
39lung disease9.8
40fundus dystrophy9.8IL6, MPO, SERPINA1
41kidney angiomyolipoma9.8IL6, MPO, SOD2
42diplegia of upper limb9.8GSTM1, GSTT1, MPO, SOD2
43hidrocystoma9.8GSTM1, GSTP1, GSTT1, OGG1
44phagocyte bactericidal dysfunction9.8IL6, MPO, SOD2
45follicular adenoma9.8MPO, THBD
46paratyphoid fever9.8MPO, THBD
47osmotic diarrhea9.7IL6, THBD
48laryngitis9.7
49peritonitis9.7
50intestinal variant cervical mucinous adenocarcinoma9.7IL6, MPO

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN):


Postinflammatory Pulmonary FibrosisProstatic Hypertrophy
Respiratory FailureBronchitis
Chronic Pulmonary Heart DiseaseCoronary Artery Disease
Deficiency AnemiaFamilial Atrial Fibrillation
Heart DiseaseIntermediate Coronary Syndrome
Ischemic Heart DiseaseProstate Cancer

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms & Phenotypes for Asbestosis

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GenomeRNAi Phenotypes related to Asbestosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00101-A-39.6KIF5A, SOD2

Drugs & Therapeutics for Asbestosis

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Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ArtichokeNutraceuticalPhase 28
2Respiratory System Agents4818
3XenonEarly Phase 166

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed PopulationCompletedNCT02076672Phase 2
2Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
3Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early DiagnosisRecruitingNCT02280343
4Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung DisordersNot yet recruitingNCT02748798Early Phase 1

Search NIH Clinical Center for Asbestosis


Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

36
Lung, Testes, Neutrophil, Nk cells, T cells, Testis, Colon

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. (28083692)
2017
2
Collegium Ramazzini response to 'Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations'. (26637163)
2016
3
Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique. (27575267)
2016
4
Exposure-response estimate for lung cancer and asbestosis in a predominantly chrysotile-exposed Chinese factory cohort. (26969815)
2016
5
Usual interstitial pneumonia in asbestos exposed cohorts - concurrent idiopathic pulmonary fibrosis or atypical asbestosis? (26864248)
2016
6
Learning to identify the benign thoracic manifestations of asbestosis from a single patient. (27302641)
2016
7
The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. (26901505)
2016
8
Radiologic Diagnosis of Asbestosis in Korea. (27587956)
2016
9
Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis. (27043967)
2016
10
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. (26071911)
2015
11
Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. (26334510)
2015
12
Asbestosis in a Japanese Macaque (Macaca fuscata). (26056144)
2015
13
Occupationally acquired asbestosis in a healthcare worker. (26253085)
2015
14
Iron and Iron-Related Proteins in Asbestosis. (26756421)
2015
15
Smoking-associated fibrosis and pulmonary asbestosis. (25565798)
2015
16
Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended. (25878233)
2015
17
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. (25999705)
2015
18
Retroperitoneal fibrosis and asbestosis--a plausible association? (25445100)
2015
19
Risk assessment of gastric cancer associated with asbestosis: a case report. (25908993)
2015
20
Asbestosis and environmental causes of usual interstitial pneumonia. (25621562)
2015
21
Asbestosis: The Scam That Refuses to Die. (26168581)
2015
22
Commentary on pathologic diagnosis of asbestosis and critique of the 2010 Asbestosis Committee of the College of American Pathologists (CAP) and Pulmonary Pathology Society's (PPS) update on the diagnostic criteria for pathologic asbestosis. (26374489)
2015
23
Pathological confirmed diagnosis of asbestosis: the first case report in Thailand. (25920303)
2015
24
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
25
Asbestosis, not asbestos exposure, is the primary risk factor for lung cancer. (24381996)
2014
26
0043a88Benign pleural abnormalities and mesothelioma among asbestosis workers in Hong Kong. (25018430)
2014
27
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
28
Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. (25299403)
2014
29
Asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381997)
2014
30
Pulmonary tuberculosis complicating asbestosis. (24914084)
2014
31
Bronchoalveolar neutrophilia inversely correlates with DLCO at diagnosis in asbestosis but not lung function decline at 1 year. (23825766)
2013
32
The influence of gene-gene and gene-environment interactions on the risk of asbestosis. (23984360)
2013
33
YKL-40 and Mesothelin in the Blood of Patients with Malignant Mesothelioma, Lung Cancer and Asbestosis. (24324091)
2013
34
Descriptive review of asbestosis and silicosis hospitalization trends in North Carolina, 2002-2011. (24165760)
2013
35
Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American insulator cohort. (23590275)
2013
36
Pulmonary tuberculosis and lung cancer mortality in a historical cohort of workers with asbestosis. (23164612)
2012
37
Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report. (22742509)
2012
38
Asbestosis: Past voices from the Mumbai factory floor. (23776323)
2012
39
Mortality from asbestosis and mesothelioma in Britain by birth cohort. (23034792)
2012
40
Mesothelioma and lung cancer mortality: a historical cohort study among asbestosis workers in Hong Kong. (22129857)
2012
41
Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis. (21742741)
2012
42
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
43
An elderly man with fibrotic lung disease. Asbestosis, pleural plaques, and rounded atelectasis. (21484007)
2011
44
Occult adenocarcinoma of the lung mimicking rapid progression of asbestosis. (21532232)
2011
45
Lung diffusing capacity relates better to short-term progression on HRCT abnormalities than spirometry in mild asbestosis. (21298694)
2011
46
Asbestosis. (21281828)
2011
47
Regarding "absence of radiographic asbestosis and the risk of lung cancer among asbestos-cement workers: extended follow-up of a cohort", by Murray Finkelstein, American Journal of Industrial Medicine 2010. (21328422)
2011
48
Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis. (21660141)
2011
49
Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. (21534086)
2011
50
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. (21704503)
2011

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.3GSTP1, IL6, MPO, SERPINA1, SOD3, THBD

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1acute inflammatory responseGO:000252610.4IL6, OGG1
2acute-phase responseGO:000695310.3IL6, SERPINA1
3negative regulation of fat cell differentiationGO:004559910.2IL6, SOD2
4positive regulation of nitric oxide biosynthetic processGO:004542910.2IL6, SOD2
5response to coldGO:000940910.2IL6, SOD2
6response to electrical stimulusGO:005160210.2IL6, SOD2
7response to radiationGO:000931410.2OGG1, SOD2
8negative regulation of fibroblast proliferationGO:004814710.1GSTP1, SOD2
9response to L-ascorbic acidGO:003359110.1GSTP1, SOD2
10glutathione derivative biosynthetic processGO:190168710.0GSTM1, GSTP1, GSTT1
11response to amino acidGO:004320010.0GSTP1, IL6
12removal of superoxide radicalsGO:00194309.9MPO, SOD2, SOD3
13glutathione metabolic processGO:00067499.6GSTM1, GSTP1, GSTT1, SOD2
14response to nutrient levelsGO:00316679.5GSTP1, IL6, SOD2
15response to yeastGO:00018789.4IL6, MPO
16response to oxidative stressGO:00069799.4MPO, OGG1, SOD2, SOD3
17agingGO:00075689.4IL6, MPO, OGG1, SOD2
18response to reactive oxygen speciesGO:00003029.3GSTP1, SOD2, SOD3
19response to lipopolysaccharideGO:00324968.8IL6, MPO, SOD2, THBD
20negative regulation of apoptotic processGO:00430668.8GSTP1, IL6, MPO, OGG1, SOD2

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-dependent microtubule motor activity, plus-end-directedGO:000857410.3KIF18A, KIF5A
2glutathione bindingGO:004329510.2GSTM1, GSTP1
3glutathione peroxidase activityGO:000460210.2GSTP1, GSTT1
4glutathione transferase activityGO:00043649.9GSTM1, GSTP1, GSTT1
5superoxide dismutase activityGO:00047849.8SOD2, SOD3
6microtubule bindingGO:00080179.5KIF18A, KIF5A, OGG1

Sources for Asbestosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet