MCID: ASB001
MIFTS: 43

Asbestosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

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Aliases & Descriptions for Asbestosis:

Name: Asbestosis 10 45 47 12 36 65
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 45
 
Pulmonary Fibrosis - from Asbestos Exposure 45

Classifications:



External Ids:

Disease Ontology10 DOID:10320
ICD1027 J61
ICD9CM29 501
MeSH36 D001195
NCIt42 C84573
UMLS65 C0003949

Summaries for Asbestosis

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Wikipedia:68 Asbestosis is a chronic inflammatory and scarring disease affecting the tissue of the lungs. People with... more...

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to asbestos intoxication and lung cancer. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways are Naphthalene metabolism and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. Affiliated tissues include lung, heart and t cells.

Disease Ontology:10 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1asbestos intoxication11.1
2lung cancer10.6
3filamentary keratitis10.5GSTM1, GSTT1
4ocular motility disease10.5SOD2, SOD3
5ectodermal dysplasia10.5GSTM1, GSTT1
6mast syndrome10.5SOD2, SOD3
7levator syndrome10.5GSTM1, GSTT1
8noma10.5GSTM1, GSTT1
9mutiple parosteal osteochondromatous proliferations10.5GSTM1, GSTT1
10scleromalacia perforans10.5GSTM1, GSTT1
11giant hemangioma10.4GSTM1, GSTT1
12diffuse idiopathic pulmonary neuroendocrine cell hyperplasia10.4GSTM1, GSTT1
13silicosis10.4
14night blindness, congenital stationary , 1d, autosomal recessive10.3GSTM1, GSTT1
15heart aneurysm10.3CAT, SOD3
16glottis neoplasm10.3GSTM1, GSTT1, OGG1
17placental insufficiency10.2GSTM1, GSTT1, OGG1
18alopecia10.2GSTM1, SOD2
19pulmonary fibrosis10.2
20melanoma10.2MUC1, SERPINA1
21pneumoconiosis10.2
22lymphoplasmacyte-rich meningioma10.1MUC1, SERPINA1
23familial short qt syndrome10.1GSTM1, MUC1, SOD2
24tetrasomy 2110.1CAT, SOD2
25adenocarcinoma10.1
26tuberculosis10.0
27pneumonia10.0
28recurrent hypersomnia10.0CAT, GSTM1, SOD2
29mucinous cystadenocarcinoma10.0CAT, GSTM1, GSTT1
30interstitial lung disease10.0
31autonomic peripheral neuropathy10.0CAT, GSTM1, GSTT1
32pulmonary tuberculosis9.9
33lung disease9.9
34pleural mesothelioma9.9
35thoracic outlet syndrome9.9CAT, SOD2
36endocarditis9.9IL6, SERPINA1
37berylliosis9.8
38stomach cancer9.8
39laryngitis9.8
40peritonitis9.8
41retroperitoneal lymphoma9.8GSTM1, GSTT1, IL6
42bardet-biedl syndrome 89.7IL6, SERPINA1
43systemic lupus erythematosus9.7
44hodgkin lymphoma9.7
45multiple myeloma9.7
46insulin-like growth factor i9.7
47gastric cancer9.7
48leukemia9.7
49lymphoma9.7
50myeloma9.7

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN):


Postinflammatory Pulmonary FibrosisProstatic Hypertrophy
Respiratory FailureBronchitis
Chronic Pulmonary Heart DiseaseCoronary Artery Disease
Deficiency AnemiaFamilial Atrial Fibrillation
Heart DiseaseIntermediate Coronary Syndrome
Ischemic Heart DiseaseProstate Cancer

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ArtichokeNutraceuticalPhase 28
2Respiratory System Agents3931
3XenonPhase 059

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed PopulationCompletedNCT02076672Phase 2
2Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
3Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early DiagnosisRecruitingNCT02280343
4Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung DisordersNot yet recruitingNCT02748798Phase 0

Search NIH Clinical Center for Asbestosis


Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

33
Lung, Heart, T cells, Bone, Kidney, Liver, Prostate

Animal Models for Asbestosis or affiliated genes

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MGI Mouse Phenotypes related to Asbestosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. (25999705)
2015
2
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. (26071911)
2015
3
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
4
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
5
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
6
Asbestosis and mesothelioma among British asbestos workers (1971-2005). (20957726)
2010
7
Serum growth factors in asbestosis patients. (19283526)
2009
8
Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases. (19523203)
2009
9
Pleural plaques and asbestosis: dose- and time-response relationships based on HRCT data. (19129281)
2009
10
Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease. (10543275)
1999
11
New technologies in diagnosing occupational asbestosis. (10376357)
1998
12
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
13
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
14
Clinical predictors of mortality from asbestosis in the North American Insulator Cohort, 1981 to 1991. (9230732)
1997
15
Professor Matthew Stewart: asbestosis research 1929-1934. (9327084)
1997
16
Does asbestos or asbestosis cause carcinoma of the lung? (7892835)
1994
17
Asbestos fiber analysis in seven asbestosis cases. (8117151)
1994
18
Gamma/delta T-lymphocytes in advanced pulmonary asbestosis. (8140322)
1993
19
Computed tomography in the early detection of asbestosis. (8398855)
1993
20
Bronchoalveolar lavage and 99mTc-DTPA clearance as prognostic factors in asbestos workers with and without asbestosis. (8209056)
1993
21
Current imaging of asbestosis. (2701517)
1989
22
Roentgenographic underestimation of early asbestosis. (2707080)
1989
23
Validation of clinical criteria for diagnosing asbestosis in asbestos-cement workers. (2489415)
1989
24
Asbestosis occurring after brief inhalational exposure: usefulness of bronchoalveolar lavage in diagnosis. (2538140)
1989
25
Asbestosis among electricians. (3262731)
1988
26
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
27
The association of carcinoma, tuberculosis, asbestosis, and fibrosing alveolitis of the lung: report of a case and review of the literature. (3679907)
1987
28
Immunogenetic factors as determinants of asbestosis. (3108592)
1987
29
Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. (3706896)
1986
30
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
31
Diagnosis of asbestosis. Clinical, radiological and lung function data in 42 patients. (6527564)
1984
32
Asbestos related diseases without asbestosis. (6223683)
1983
33
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
34
Incipient cases of asbestosis in a Kenyan factory. (6671435)
1983
35
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
36
Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure. (7249746)
1981
37
The development of asbestosis. (18748527)
1980
38
Asbestosis in the industries of the Barcelona area. (7342762)
1980
39
Asbestosis: a study of dose-response relationships in an asbestos textile factory. (465379)
1979
40
Computed tomography in pulmonary asbestosis. (436371)
1979
41
Elimination of asbestosis. (651728)
1978
42
Asbestosis. (73933)
1977
43
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. (872451)
1977
44
Diagnosis of asbestosis by transbronchial biopsy. A method to facilitate demonstration of ferruginous bodies. (848793)
1977
45
A survey of patients diagnosed as having asbestosis. (135908)
1976
46
Proceedings: HL-A type and asbestosis. (1181698)
1975
47
Asbestosis and neoplastic disorders of the hematopoietic system. (4984519)
1970
48
The radiology of asbestosis. (5798718)
1969
49
Mucociliary function in health, chronic obstructive airway disease, and asbestosis. (5781603)
1969
50
SILICO-ANTHRACOSIS PRESENTING CURIOUS BODIES SIMILAR TO THOSE IN ASBESTOSIS. (20776780)
1932

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Golgi lumenGO:00057969.6MUC1, SOD3

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1response to L-ascorbic acidGO:00335919.9CAT, SOD2
2response to radiationGO:00093149.9CAT, SOD2
3response to cadmium ionGO:00466869.9CAT, SOD2
4cellular oxidant detoxificationGO:00988699.7CAT, GSTT1
5response to coldGO:00094099.7IL6, SOD2
6response to nutrient levelsGO:00316679.6IL6, SOD2
7acute-phase responseGO:00069539.6IL6, SERPINA1
8superoxide metabolic processGO:00068019.6SOD2, SOD3
9glutathione metabolic processGO:00067499.6GSTM1, GSTT1, SOD2
10response to electrical stimulusGO:00516029.4IL6, SOD2
11agingGO:00075688.8CAT, IL6, SOD2
12response to oxidative stressGO:00069798.7CAT, OGG1, SOD2, SOD3
13response to drugGO:00424938.6CAT, IL6, SOD2

Sources for Asbestosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet