MCID: ASB001
MIFTS: 42

Asbestosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

Aliases & Descriptions for Asbestosis:

Name: Asbestosis 12 50 52 42 14 69
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 50
Pulmonary Fibrosis - from Asbestos Exposure 50

Classifications:



External Ids:

Disease Ontology 12 DOID:10320
ICD10 33 J61
ICD9CM 35 501
MeSH 42 D001195
NCIt 47 C84573
UMLS 69 C0003949

Summaries for Asbestosis

Disease Ontology : 12 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

MalaCards based summary : Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to asbestos intoxication and interstitial lung disease. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways/superpathways are Folate Metabolism and Glutathione metabolism. The drugs Artichoke and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and neutrophil, and related phenotype is Synthetic lethal with paclitaxel.

Wikipedia : 71 Asbestosis is a chronic inflammatory and scarring disease affecting the tissue of the lungs. People with... more...

Related Diseases for Asbestosis

Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 60)
id Related Disease Score Top Affiliating Genes
1 asbestos intoxication 11.0
2 interstitial lung disease 10.8
3 lung cancer 10.4
4 silicosis 10.2
5 differentiated thyroid carcinoma 10.2 GSTM1 GSTT1
6 emery-dreifuss muscular dystrophy, x-linked 10.1 GSTM1 GSTT1
7 pulmonary fibrosis 10.1
8 rapsn-related fetal akinesia deformation sequence 10.1 GSTM1 GSTT1 SOD2
9 de quervain disease 10.1 SERPINA1 THBD
10 mucopolysaccharidosis 10.1 SOD2 SOD3
11 pneumoconiosis 10.1
12 immune system disease 10.0 GSTM1 GSTT1 IL6
13 hepatic flexure cancer 10.0 GSTM1 GSTP1 GSTT1
14 placenta praevia 10.0 GSTM1 GSTP1 GSTT1
15 adenocarcinoma 10.0
16 villous adenoma 10.0 GSTM1 GSTT1 MPO
17 uvula cancer 9.9 GSTM1 GSTT1 MPO
18 tuberculosis 9.9
19 pleural disease 9.9
20 hidradenoma 9.9 GSTM1 GSTP1 GSTT1 OGG1
21 hypogonadotropic hypogonadism 20 with or without anosmia 9.9 GSTM1 GSTP1 GSTT1
22 pneumonia 9.9
23 acute proliferative glomerulonephritis 9.8 GSTP1 IL6 THBD
24 angiomatosis, diffuse corticomeningeal, of divry and van bogaert 9.8 IL6 MPO SERPINA1
25 lung disease 9.8
26 pulmonary tuberculosis 9.8
27 acute chest syndrome 9.8 IL6 MPO SERPINA1
28 eating disorder 9.8 MPO SERPINA1 THBD
29 ladd syndrome 9.8 GSTM1 GSTP1 GSTT1
30 major depressive disorder and accelerated response to antidepressant drug treatment 9.8 IL6 MPO SERPINA1
31 breast apocrine carcinoma in situ 9.8 IL6 MPO SOD2
32 childhood malignant hemangiopericytoma 9.8 IL6 MPO SERPINA1
33 subcorneal pustular dermatosis 9.7 IL6 MPO SERPINA1
34 laryngitis 9.7
35 berylliosis 9.7
36 peritonitis 9.7
37 gastric cancer 9.6
38 leukemia 9.6
39 lymphoma 9.6
40 malignant biphasic mesothelioma 9.6
41 pleural cancer 9.6
42 caplan's syndrome 9.6
43 malignant pleural mesothelioma 9.6
44 anthracosis 9.6
45 siderosis 9.6
46 extrinsic allergic alveolitis 9.6
47 systemic lupus erythematosus 9.6
48 sarcoma 9.6
49 constrictive pericarditis 9.6
50 lupus erythematosus 9.6

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN): (show all 12)


Bronchitis Chronic Myocardial Ischemia
Chronic Pulmonary Heart Disease Deficiency Anemia
Familial Atrial Fibrillation Heart Disease
Intermediate Coronary Syndrome Ischemic Heart Disease
Postinflammatory Pulmonary Fibrosis Prostate Cancer
Prostatic Hypertrophy Respiratory Failure

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to Asbestosis

Symptoms & Phenotypes for Asbestosis

GenomeRNAi Phenotypes related to Asbestosis according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with paclitaxel GR00101-A-3 8.62 KIF5A SOD2

Drugs & Therapeutics for Asbestosis

Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1 Artichoke Nutraceutical Phase 2
2 Respiratory System Agents
3 Xenon Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase
1 Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed Population Completed NCT02076672 Phase 2
2 Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early Diagnosis Unknown status NCT02280343
3 Specialized Center of Research in Occupational and Immunologic Lung Disease Completed NCT00005280
4 Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung Disorders Not yet recruiting NCT02748798 Early Phase 1

Search NIH Clinical Center for Asbestosis

Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

Anatomical Context for Asbestosis

MalaCards organs/tissues related to Asbestosis:

39
Lung, Testes, Neutrophil, T Cells, Colon, Nk Cells, Testis

Publications for Asbestosis

Articles related to Asbestosis:

(show top 50) (show all 521)
id Title Authors Year
1
Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. ( 28083692 )
2017
2
Radiologic Diagnosis of Asbestosis in Korea. ( 27587956 )
2016
3
Exposure-response estimate for lung cancer and asbestosis in a predominantly chrysotile-exposed Chinese factory cohort. ( 26969815 )
2016
4
Usual interstitial pneumonia in asbestos exposed cohorts - concurrent idiopathic pulmonary fibrosis or atypical asbestosis? ( 26864248 )
2016
5
Learning to identify the benign thoracic manifestations of asbestosis from a single patient. ( 27302641 )
2016
6
Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis. ( 27043967 )
2016
7
Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique. ( 27575267 )
2016
8
The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. ( 26901505 )
2016
9
Collegium Ramazzini response to 'Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations'. ( 26637163 )
2016
10
Asbestosis and environmental causes of usual interstitial pneumonia. ( 25621562 )
2015
11
Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. ( 26334510 )
2015
12
Pathological confirmed diagnosis of asbestosis: the first case report in Thailand. ( 25920303 )
2015
13
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. ( 26071911 )
2015
14
Iron and Iron-Related Proteins in Asbestosis. ( 26756421 )
2015
15
Asbestosis: The Scam That Refuses to Die. ( 26168581 )
2015
16
Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended. ( 25878233 )
2015
17
Occupationally acquired asbestosis in a healthcare worker. ( 26253085 )
2015
18
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. ( 25999705 )
2015
19
Smoking-associated fibrosis and pulmonary asbestosis. ( 25565798 )
2015
20
Risk assessment of gastric cancer associated with asbestosis: a case report. ( 25908993 )
2015
21
Commentary on pathologic diagnosis of asbestosis and critique of the 2010 Asbestosis Committee of the College of American Pathologists (CAP) and Pulmonary Pathology Society's (PPS) update on the diagnostic criteria for pathologic asbestosis. ( 26374489 )
2015
22
Retroperitoneal fibrosis and asbestosis--a plausible association? ( 25445100 )
2015
23
Asbestosis in a Japanese Macaque (Macaca fuscata). ( 26056144 )
2015
24
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. ( 25286915 )
2014
25
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. ( 24381998 )
2014
26
0043a88Benign pleural abnormalities and mesothelioma among asbestosis workers in Hong Kong. ( 25018430 )
2014
27
Pulmonary tuberculosis complicating asbestosis. ( 24914084 )
2014
28
Asbestosis, not asbestos exposure, is the primary risk factor for lung cancer. ( 24381996 )
2014
29
Asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. ( 24381997 )
2014
30
Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. ( 25299403 )
2014
31
The influence of gene-gene and gene-environment interactions on the risk of asbestosis. ( 23984360 )
2013
32
Descriptive review of asbestosis and silicosis hospitalization trends in North Carolina, 2002-2011. ( 24165760 )
2013
33
YKL-40 and Mesothelin in the Blood of Patients with Malignant Mesothelioma, Lung Cancer and Asbestosis. ( 24324091 )
2013
34
Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American insulator cohort. ( 23590275 )
2013
35
Bronchoalveolar neutrophilia inversely correlates with DLCO at diagnosis in asbestosis but not lung function decline at 1 year. ( 23825766 )
2013
36
Asbestosis: Past voices from the Mumbai factory floor. ( 23776323 )
2012
37
Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report. ( 22742509 )
2012
38
Pulmonary tuberculosis and lung cancer mortality in a historical cohort of workers with asbestosis. ( 23164612 )
2012
39
Mesothelioma and lung cancer mortality: a historical cohort study among asbestosis workers in Hong Kong. ( 22129857 )
2012
40
Mortality from asbestosis and mesothelioma in Britain by birth cohort. ( 23034792 )
2012
41
Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis. ( 21742741 )
2012
42
Regarding "absence of radiographic asbestosis and the risk of lung cancer among asbestos-cement workers: extended follow-up of a cohort", by Murray Finkelstein, American Journal of Industrial Medicine 2010. ( 21328422 )
2011
43
Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. ( 21231887 )
2011
44
Talc asbestosis and pulmonary tuberculosis in a patient exposed to the talc used in the production of soccer balls. ( 21881748 )
2011
45
Clinical, radiological, and pathological investigation of asbestosis. ( 21556185 )
2011
46
Asbestosis. ( 21281828 )
2011
47
An elderly man with fibrotic lung disease. Asbestosis, pleural plaques, and rounded atelectasis. ( 21484007 )
2011
48
Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. ( 21534086 )
2011
49
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. ( 22324095 )
2011
50
Asbestos-related cancer risk in patients with asbestosis or pleural plaques. ( 21742228 )
2011

Variations for Asbestosis

Expression for Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for Asbestosis

Pathways related to Asbestosis according to GeneCards Suite gene sharing:

(show all 13)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.04 IL6 MPO SOD2 SOD3
2
Show member pathways
11.99 GSTM1 GSTP1 GSTT1
3 11.78 GSTM1 GSTP1 SERPINA1 SOD3
4 11.7 GSTM1 GSTP1 GSTT1 THBD
5
Show member pathways
11.55 GSTM1 GSTP1 GSTT1
6 11.5 GSTM1 GSTP1 GSTT1
7
Show member pathways
11.28 GSTP1 SOD2 SOD3
8 11.06 IL6 THBD
9 10.99 SOD2 SOD3
10 10.71 GSTM1 GSTP1 GSTT1
11 10.39 GSTM1 GSTP1 GSTT1 MPO
12 10.31 GSTP1 GSTT1 MPO
13 10.21 GSTM1 MPO

GO Terms for Asbestosis

Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.1 GSTP1 IL6 MPO SERPINA1 SOD3 THBD

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 20)
id Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.8 GSTP1 IL6 MPO OGG1 SOD2
2 cellular response to oxidative stress GO:0034599 9.69 GSTP1 SOD2 SOD3
3 cellular oxidant detoxification GO:0098869 9.67 GSTP1 GSTT1 MPO
4 response to lipopolysaccharide GO:0032496 9.67 IL6 MPO SOD2 THBD
5 aging GO:0007568 9.62 IL6 MPO OGG1 SOD2
6 response to nutrient levels GO:0031667 9.61 GSTP1 IL6 SOD2
7 cellular response to estradiol stimulus GO:0071392 9.59 IL6 KIF18A
8 response to amino acid GO:0043200 9.58 GSTP1 IL6
9 acute-phase response GO:0006953 9.58 IL6 SERPINA1
10 response to radiation GO:0009314 9.57 OGG1 SOD2
11 negative regulation of fibroblast proliferation GO:0048147 9.56 GSTP1 SOD2
12 response to oxidative stress GO:0006979 9.56 MPO OGG1 SOD2 SOD3
13 response to electrical stimulus GO:0051602 9.55 IL6 SOD2
14 superoxide metabolic process GO:0006801 9.54 SOD2 SOD3
15 acute inflammatory response GO:0002526 9.52 IL6 OGG1
16 response to yeast GO:0001878 9.48 IL6 MPO
17 response to L-ascorbic acid GO:0033591 9.46 GSTP1 SOD2
18 glutathione derivative biosynthetic process GO:1901687 9.33 GSTM1 GSTP1 GSTT1
19 removal of superoxide radicals GO:0019430 9.13 MPO SOD2 SOD3
20 glutathione metabolic process GO:0006749 8.92 GSTM1 GSTP1 GSTT1 SOD2

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 microtubule binding GO:0008017 9.54 KIF18A KIF5A OGG1
2 glutathione peroxidase activity GO:0004602 9.32 GSTP1 GSTT1
3 ATP-dependent microtubule motor activity, plus-end-directed GO:0008574 9.26 KIF18A KIF5A
4 glutathione binding GO:0043295 9.16 GSTM1 GSTP1
5 superoxide dismutase activity GO:0004784 8.96 SOD2 SOD3
6 glutathione transferase activity GO:0004364 8.8 GSTM1 GSTP1 GSTT1

Sources for Asbestosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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