MCID: ASB001
MIFTS: 42

Asbestosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

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Aliases & Descriptions for Asbestosis:

Name: Asbestosis 11 48 50 39 13 68
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 48
 
Pulmonary Fibrosis - from Asbestos Exposure 48

Classifications:



External Ids:

Disease Ontology11 DOID:10320
ICD1030 J61
ICD9CM32 501
MeSH39 D001195
NCIt45 C84573

Summaries for Asbestosis

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Wikipedia:71 Asbestosis is a chronic inflammatory and scarring disease affecting the tissue of the lungs. People with... more...

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to asbestos intoxication and interstitial lung disease. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways are Oxidative Stress and Validated transcriptional targets of AP1 family members Fra1 and Fra2. Affiliated tissues include lung, testes and neutrophil, and related mouse phenotype Synthetic lethal with paclitaxel.

Disease Ontology:11 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 60)
idRelated DiseaseScoreTop Affiliating Genes
1asbestos intoxication11.0
2interstitial lung disease10.8
3lung cancer10.4
4silicosis10.2
5differentiated thyroid carcinoma10.2GSTM1, GSTT1
6emery-dreifuss muscular dystrophy, x-linked10.1GSTM1, GSTT1
7pulmonary fibrosis10.1
8rapsn-related fetal akinesia deformation sequence10.1GSTM1, GSTT1, SOD2
9de quervain disease10.1SERPINA1, THBD
10mucopolysaccharidosis10.1SOD2, SOD3
11pneumoconiosis10.1
12immune system disease10.0GSTM1, GSTT1, IL6
13hepatic flexure cancer10.0GSTM1, GSTP1, GSTT1
14placenta praevia10.0GSTM1, GSTP1, GSTT1
15adenocarcinoma10.0
16villous adenoma10.0GSTM1, GSTT1, MPO
17uvula cancer9.9GSTM1, GSTT1, MPO
18pleural disease9.9
19tuberculosis9.9
20hidradenoma9.9GSTM1, GSTP1, GSTT1, OGG1
21hypogonadotropic hypogonadism 20 with or without anosmia9.9GSTM1, GSTP1, GSTT1
22pneumonia9.9
23acute proliferative glomerulonephritis9.8GSTP1, IL6, THBD
24angiomatosis, diffuse corticomeningeal, of divry and van bogaert9.8IL6, MPO, SERPINA1
25pulmonary tuberculosis9.8
26lung disease9.8
27acute chest syndrome9.8IL6, MPO, SERPINA1
28eating disorder9.8MPO, SERPINA1, THBD
29ladd syndrome9.8GSTM1, GSTP1, GSTT1
30major depressive disorder and accelerated response to antidepressant drug treatment9.8IL6, MPO, SERPINA1
31breast apocrine carcinoma in situ9.8IL6, MPO, SOD2
32childhood malignant hemangiopericytoma9.8IL6, MPO, SERPINA1
33subcorneal pustular dermatosis9.7IL6, MPO, SERPINA1
34berylliosis9.7
35laryngitis9.7
36peritonitis9.7
37systemic lupus erythematosus9.6
38hodgkin lymphoma9.6
39multiple myeloma9.6
40insulin-like growth factor i9.6
41temporal arteritis9.6
42gastric cancer9.6
43leukemia9.6
44lymphoma9.6
45caplan's syndrome9.6
46anthracosis9.6
47siderosis9.6
48sarcoma9.6
49constrictive pericarditis9.6
50pericarditis9.6

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN):


Postinflammatory Pulmonary FibrosisProstatic Hypertrophy
Respiratory FailureBronchitis
Chronic Myocardial IschemiaChronic Pulmonary Heart Disease
Deficiency AnemiaFamilial Atrial Fibrillation
Heart DiseaseIntermediate Coronary Syndrome
Ischemic Heart DiseaseProstate Cancer

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms & Phenotypes for Asbestosis

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GenomeRNAi Phenotypes related to Asbestosis according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00101-A-39.6KIF5A, SOD2

Drugs & Therapeutics for Asbestosis

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Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ArtichokeNutraceuticalPhase 28
2Respiratory System Agents4997
3XenonEarly Phase 168

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed PopulationCompletedNCT02076672Phase 2
2Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early DiagnosisUnknown statusNCT02280343
3Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
4Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung DisordersNot yet recruitingNCT02748798Early Phase 1

Search NIH Clinical Center for Asbestosis


Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

36
Lung, Testes, Neutrophil, Nk cells, T cells, Testis, Colon

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 521)
idTitleAuthorsYear
1
Correlation of ultra-low dose chest CT findings with physiologic measures of asbestosis. (28083692)
2017
2
Radiologic Diagnosis of Asbestosis in Korea. (27587956)
2016
3
Exposure-response estimate for lung cancer and asbestosis in a predominantly chrysotile-exposed Chinese factory cohort. (26969815)
2016
4
Usual interstitial pneumonia in asbestos exposed cohorts - concurrent idiopathic pulmonary fibrosis or atypical asbestosis? (26864248)
2016
5
Learning to identify the benign thoracic manifestations of asbestosis from a single patient. (27302641)
2016
6
Carcinoma of the lung in the absence of asbestosis: The value of lung fiber burden analysis. (27043967)
2016
7
Pathology of Asbestosis: An Update of the Diagnostic Criteria Response to a Critique. (27575267)
2016
8
The comparison of high-resolution computed tomography findings in asbestosis and idiopathic pulmonary fibrosis. (26901505)
2016
9
Collegium Ramazzini response to 'Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations'. (26637163)
2016
10
Asbestosis and environmental causes of usual interstitial pneumonia. (25621562)
2015
11
Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. (26334510)
2015
12
Pathological confirmed diagnosis of asbestosis: the first case report in Thailand. (25920303)
2015
13
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. (26071911)
2015
14
Iron and Iron-Related Proteins in Asbestosis. (26756421)
2015
15
Asbestosis: The Scam That Refuses to Die. (26168581)
2015
16
Parenchymal asbestosis can lead to lung cancer within a short time frame: more frequent follow-up surveillance is needed than currently recommended. (25878233)
2015
17
Occupationally acquired asbestosis in a healthcare worker. (26253085)
2015
18
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. (25999705)
2015
19
Smoking-associated fibrosis and pulmonary asbestosis. (25565798)
2015
20
Risk assessment of gastric cancer associated with asbestosis: a case report. (25908993)
2015
21
Commentary on pathologic diagnosis of asbestosis and critique of the 2010 Asbestosis Committee of the College of American Pathologists (CAP) and Pulmonary Pathology Society's (PPS) update on the diagnostic criteria for pathologic asbestosis. (26374489)
2015
22
Retroperitoneal fibrosis and asbestosis--a plausible association? (25445100)
2015
23
Asbestosis in a Japanese Macaque (Macaca fuscata). (26056144)
2015
24
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
25
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
26
0043a88Benign pleural abnormalities and mesothelioma among asbestosis workers in Hong Kong. (25018430)
2014
27
Pulmonary tuberculosis complicating asbestosis. (24914084)
2014
28
Asbestosis, not asbestos exposure, is the primary risk factor for lung cancer. (24381996)
2014
29
Asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381997)
2014
30
Asbestos, asbestosis, and cancer, the Helsinki criteria for diagnosis and attribution 2014: recommendations. (25299403)
2014
31
The influence of gene-gene and gene-environment interactions on the risk of asbestosis. (23984360)
2013
32
Descriptive review of asbestosis and silicosis hospitalization trends in North Carolina, 2002-2011. (24165760)
2013
33
YKL-40 and Mesothelin in the Blood of Patients with Malignant Mesothelioma, Lung Cancer and Asbestosis. (24324091)
2013
34
Asbestos, asbestosis, smoking, and lung cancer. New findings from the North American insulator cohort. (23590275)
2013
35
Bronchoalveolar neutrophilia inversely correlates with DLCO at diagnosis in asbestosis but not lung function decline at 1 year. (23825766)
2013
36
Asbestosis: Past voices from the Mumbai factory floor. (23776323)
2012
37
Cryptococcus pneumonia presenting in an immunocompetent host with pulmonary asbestosis: a case report. (22742509)
2012
38
Pulmonary tuberculosis and lung cancer mortality in a historical cohort of workers with asbestosis. (23164612)
2012
39
Mesothelioma and lung cancer mortality: a historical cohort study among asbestosis workers in Hong Kong. (22129857)
2012
40
Mortality from asbestosis and mesothelioma in Britain by birth cohort. (23034792)
2012
41
Exposure-response relationship between chrysotile exposure and mortality from lung cancer and asbestosis. (21742741)
2012
42
Regarding "absence of radiographic asbestosis and the risk of lung cancer among asbestos-cement workers: extended follow-up of a cohort", by Murray Finkelstein, American Journal of Industrial Medicine 2010. (21328422)
2011
43
Proteomic detection of cancer in asbestosis patients using SELDI-TOF discovered serum protein biomarkers. (21231887)
2011
44
Talc asbestosis and pulmonary tuberculosis in a patient exposed to the talc used in the production of soccer balls. (21881748)
2011
45
Clinical, radiological, and pathological investigation of asbestosis. (21556185)
2011
46
Asbestosis. (21281828)
2011
47
An elderly man with fibrotic lung disease. Asbestosis, pleural plaques, and rounded atelectasis. (21484007)
2011
48
Pulmonary endpoints (lung carcinomas and asbestosis) following inhalation exposure to asbestos. (21534086)
2011
49
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
50
Asbestos-related cancer risk in patients with asbestosis or pleural plaques. (21742228)
2011

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.3GSTP1, IL6, MPO, SERPINA1, SOD3, THBD

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1acute inflammatory responseGO:000252610.4IL6, OGG1
2cellular response to estradiol stimulusGO:007139210.3IL6, KIF18A
3acute-phase responseGO:000695310.3IL6, SERPINA1
4response to electrical stimulusGO:005160210.1IL6, SOD2
5response to radiationGO:000931410.1OGG1, SOD2
6negative regulation of fibroblast proliferationGO:004814710.1GSTP1, SOD2
7response to L-ascorbic acidGO:003359110.0GSTP1, SOD2
8glutathione derivative biosynthetic processGO:190168710.0GSTM1, GSTP1, GSTT1
9response to amino acidGO:004320010.0GSTP1, IL6
10cellular response to oxidative stressGO:00345999.8GSTP1, SOD2, SOD3
11superoxide metabolic processGO:00068019.7SOD2, SOD3
12removal of superoxide radicalsGO:00194309.6MPO, SOD2, SOD3
13glutathione metabolic processGO:00067499.6GSTM1, GSTP1, GSTT1, SOD2
14response to yeastGO:00018789.5IL6, MPO
15cellular oxidant detoxificationGO:00988699.5GSTP1, GSTT1, MPO
16response to nutrient levelsGO:00316679.5GSTP1, IL6, SOD2
17agingGO:00075689.1IL6, MPO, OGG1, SOD2
18response to oxidative stressGO:00069799.1MPO, OGG1, SOD2, SOD3
19response to lipopolysaccharideGO:00324968.8IL6, MPO, SOD2, THBD
20negative regulation of apoptotic processGO:00430668.4GSTP1, IL6, MPO, OGG1, SOD2

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-dependent microtubule motor activity, plus-end-directedGO:000857410.3KIF18A, KIF5A
2glutathione bindingGO:004329510.2GSTM1, GSTP1
3glutathione peroxidase activityGO:000460210.2GSTP1, GSTT1
4glutathione transferase activityGO:00043649.9GSTM1, GSTP1, GSTT1
5superoxide dismutase activityGO:00047849.7SOD2, SOD3
6microtubule bindingGO:00080179.5KIF18A, KIF5A, OGG1

Sources for Asbestosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet