MCID: ASB001
MIFTS: 49

Asbestosis malady

Rare diseases, Respiratory diseases categories

Summaries for Asbestosis

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66Wikipedia, 34MalaCards
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Wikipedia:66 Asbestosis is a chronic inflammatory and fibrotic medical condition affecting the parenchymal tissue of... more...

MalaCards: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to lung cancer and adenocarcinoma. An important gene associated with Asbestosis is GSTT1 (glutathione S-transferase theta 1), and among its related pathways are Chemical carcinogenesis and Platinum Pathway, Pharmacokinetics/Pharmacodynamics. The compounds drugs for treatment of tuberculosis and n-(2-hydroxyethyl)valine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and liver, and related mouse phenotype homeostasis/metabolism.

Aliases & Classifications for Asbestosis

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 11DISEASES, 46Novoseek, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

asbestosis 9 44 11 46 63
idiopathic interstitial pneumonitis - from asbestos exposure 44
pulmonary fibrosis - from asbestos exposure 44
asbestosis nos 9


External Ids:

Disease Ontology9 DOID:10320
NCIt41 C84573
MeSH36 D001195
ICD9CM28 501

Related Diseases for Asbestosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Asbestosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 74)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.1GSTM1, OGG1, GSTT1
2adenocarcinoma30.4GSTM1, OGG1, GSTT1
3pneumonia30.1SOD3, GSTM1
4lung adenocarcinoma29.9OGG1, GSTM1, GSTT1
5non-hodgkin lymphoma29.9OGG1, GSTT1, GSTM1
6stomach cancer29.9GSTM1, GSTT1, OGG1
7silicosis10.6
8pulmonary function10.4
9pneumoconiosis10.4
10pulmonary fibrosis10.4
11idiopathic pulmonary fibrosis10.3
12tuberculosis10.2
13malignant mesothelioma10.2
14pulmonary tuberculosis10.1
15berylliosis10.1
16laryngitis10.1
17peritonitis10.1
18asbestos intoxication10.1
19brain cancer10.1GSTM1, GSTT1
20senile cataract10.1GSTM1, GSTT1
21open-angle glaucoma10.1GSTM1, GSTT1
22acute myeloid leukemia, adult10.1GSTT1, GSTM1
23leukoplakia10.1GSTT1, GSTM1
24laryngeal benign neoplasm10.1GSTM1, GSTT1
25aplastic anemia10.1GSTM1, GSTT1
26laryngeal squamous cell carcinoma10.1GSTM1, GSTT1
27bladder carcinoma10.1GSTM1, GSTT1
28acute lymphoblastic leukemia, childhood10.1GSTT1, GSTM1
29basal cell carcinoma10.1GSTM1, GSTT1
30oral cancer10.1GSTT1, GSTM1
31nasopharynx carcinoma10.1GSTM1, GSTT1
32transitional cell carcinoma10.0GSTM1, GSTT1
33xeroderma pigmentosum10.0OGG1, GSTT1
34thyroid cancer10.0GSTT1, GSTM1
35gastric adenocarcinoma10.0GSTM1, GSTT1
36myelodysplastic syndromes10.0GSTT1, GSTM1
37endometriosis10.0GSTM1, GSTT1
38non-small cell lung carcinoma10.0GSTM1, OGG1
39squamous cell carcinoma of the head and neck10.0GSTT1, OGG1, GSTM1
40cervical cancer10.0GSTT1, GSTM1
41lung small cell carcinoma10.0GSTM1, GSTT1, OGG1
42acute leukemia10.0GSTM1, GSTT1, OGG1
43adenoma10.0GSTT1, GSTM1, OGG1
44colon cancer10.0GSTT1, GSTM1, OGG1
45hepatocellular carcinoma10.0OGG1, GSTT1, GSTM1
46acute myocardial infarction10.0GSTM1, SOD3
47alzheimer's disease10.0OGG1, GSTT1, GSTM1
48colorectal cancer10.0GSTM1, OGG1, GSTT1
49tongue squamous cell carcinoma10.0OGG1, GSTM1, GSTT1
50pulmonary disease, chronic obstructive10.0SOD3, GSTM1, GSTT1

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Asbestosis

Drug clinical trials:

Search ClinicalTrials for Asbestosis

Search NIH Clinical Center for Asbestosis

Search CenterWatch for Asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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Sources:
34MalaCards
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MalaCards organs/tissues related to Asbestosis:

34
Lung, Testes, Liver, Bone, Bone marrow, Colon, Nk cells, T cells, Testis

Animal Models for Asbestosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Asbestosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053767.7OGG1, KIF5A, GSTT1, GSTM1, SOD3

Publications for Asbestosis

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Sources:
53PubMed
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Articles related to Asbestosis:

(show top 50)    (show all 481)
idTitleAuthorsYear
1
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
2
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
3
Asbestosis and mesothelioma among British asbestos workers (1971-2005). (20957726)
2010
4
Serum growth factors in asbestosis patients. (19283526)
2009
5
Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases. (19523203)
2009
6
Pleural plaques and asbestosis: dose- and time-response relationships based on HRCT data. (19129281)
2009
7
Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease. (10543275)
1999
8
New technologies in diagnosing occupational asbestosis. (10376357)
1998
9
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
10
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
11
Clinical predictors of mortality from asbestosis in the North American Insulator Cohort, 1981 to 1991. (9230732)
1997
12
Professor Matthew Stewart: asbestosis research 1929-1934. (9327084)
1997
13
Does asbestos or asbestosis cause carcinoma of the lung? (7892835)
1994
14
Asbestos fiber analysis in seven asbestosis cases. (8117151)
1994
15
Gamma/delta T-lymphocytes in advanced pulmonary asbestosis. (8140322)
1993
16
Computed tomography in the early detection of asbestosis. (8398855)
1993
17
Bronchoalveolar lavage and 99mTc-DTPA clearance as prognostic factors in asbestos workers with and without asbestosis. (8209056)
1993
18
Lymphocyte B and T cell subsets in peripheral blood from patients with asbestosis. (8382078)
1993
19
Current imaging of asbestosis. (2701517)
1989
20
Roentgenographic underestimation of early asbestosis. (2707080)
1989
21
Validation of clinical criteria for diagnosing asbestosis in asbestos-cement workers. (2489415)
1989
22
Asbestosis occurring after brief inhalational exposure: usefulness of bronchoalveolar lavage in diagnosis. (2538140)
1989
23
Asbestosis among electricians. (3262731)
1988
24
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
25
The association of carcinoma, tuberculosis, asbestosis, and fibrosing alveolitis of the lung: report of a case and review of the literature. (3679907)
1987
26
Immunogenetic factors as determinants of asbestosis. (3108592)
1987
27
Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. (3706896)
1986
28
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
29
Diagnosis of asbestosis. Clinical, radiological and lung function data in 42 patients. (6527564)
1984
30
Asbestos related diseases without asbestosis. (6223683)
1983
31
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
32
Incipient cases of asbestosis in a Kenyan factory. (6671435)
1983
33
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
34
Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure. (7249746)
1981
35
The development of asbestosis. (18748527)
1980
36
Asbestosis in the industries of the Barcelona area. (7342762)
1980
37
Asbestosis: a study of dose-response relationships in an asbestos textile factory. (465379)
1979
38
Computed tomography in pulmonary asbestosis. (436371)
1979
39
Absence of synergism between exposure to asbestos and cigarette smoking in asbestosis. (464386)
1979
40
Elimination of asbestosis. (651728)
1978
41
Asbestosis. (73933)
1977
42
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. (872451)
1977
43
Diagnosis of asbestosis by transbronchial biopsy. A method to facilitate demonstration of ferruginous bodies. (848793)
1977
44
A survey of patients diagnosed as having asbestosis. (135908)
1976
45
Proceedings: HL-A type and asbestosis. (1181698)
1975
46
Chest auscultation in the diagnosis of pulmonary asbestosis. (4693173)
1973
47
Asbestosis and neoplastic disorders of the hematopoietic system. (4984519)
1970
48
The radiology of asbestosis. (5798718)
1969
49
Mucociliary function in health, chronic obstructive airway disease, and asbestosis. (5781603)
1969
50
SILICO-ANTHRACOSIS PRESENTING CURIOUS BODIES SIMILAR TO THOSE IN ASBESTOSIS. (20776780)
1932

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 52PharmGKB, 39NCBI BioSystems Database, 56Reactome
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Pathways related to Asbestosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6GSTT1, GSTM1
29.6GSTT1, GSTM1
3
Show member pathways
glutathione-mediated detoxification I39
glutathione redox reactions I39
glutathione redox reactions II39
4-hydroxy-2-nonenal detoxification39
Glutathione metabolism61
Glutathione metabolism39
9.6GSTM1, GSTT1
49.6GSTT1, GSTM1
59.3KIF5A, KIF18A
69.3KIF5A, KIF18A
79.3KIF5A, KIF18A

Compounds for genes affiliated with Asbestosis

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Sources:
52PharmGKB, 46Novoseek, 12DrugBank, 25HMDB
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Compounds related to Asbestosis according to GeneCards/GeneDecks:

(show top 50)    (show all 69)
idCompoundScoreTop Affiliating Genes
1drugs for treatment of tuberculosis5210.0GSTM1, GSTT1
2n-(2-hydroxyethyl)valine4610.0GSTM1, GSTT1
3methylchloride4610.0GSTM1, GSTT1
4trans,trans-muconic acid4610.0GSTT1, GSTM1
5ethambutol52 4611.0GSTM1, GSTT1
6s-phenylmercapturic acid4610.0GSTT1, GSTM1
7hema4610.0GSTT1, GSTM1
8styrene oxide4610.0GSTM1, GSTT1
92-naphthol4610.0GSTM1, GSTT1
10butadiene monoxide4610.0GSTM1, GSTT1
11cumene hydroperoxide4610.0GSTT1, GSTM1
121,3-butadiene4610.0GSTT1, GSTM1
13vinylchloride4610.0GSTT1, GSTM1
14streptomycin52 46 1212.0GSTM1, GSTT1
15pyrazinamide46 52 1212.0GSTM1, GSTT1
16arylamine4610.0GSTM1, GSTT1
17diepoxybutane4610.0GSTT1, GSTM1
18toluene4610.0GSTT1, GSTM1
19styrene4610.0GSTM1, GSTT1
20trichloroethylene469.9GSTM1, GSTT1
211-chloro-24-dinitrobenzene469.9GSTT1, GSTM1
22benzidine469.9GSTM1, GSTT1
23chi 2469.9GSTT1, GSTM1
242-Hydroxyestrone-4-S-glutathione259.9GSTT1, GSTM1
252-Hydroxyestrone-1-S-glutathione259.9GSTT1, GSTM1
26noradrenochrome46 2510.9GSTM1, GSTT1
274-Hydroxyestrone-2-S-glutathione259.9GSTT1, GSTM1
28S-(PGJ2)-glutathione259.9GSTT1, GSTM1
29Estrone-3,4-quinone259.9GSTM1, GSTT1
30Estrone-2,3-quinone259.8GSTM1, GSTT1
31bpde469.8GSTM1, GSTT1
32hydrochloric acid46 2510.8GSTT1, GSTM1
33adrenochrome46 2510.7GSTT1, GSTM1
34isoniazid46 52 1211.7GSTT1, GSTM1
35aflatoxin b146 2510.6GSTM1, GSTT1
36rifampin52 1210.6GSTT1, GSTM1
37ethylene oxide469.5OGG1, GSTM1, GSTT1
381-hydroxypyrene469.5OGG1, GSTT1, GSTM1
398-oxo-dg469.5GSTM1, OGG1, GSTT1
408-oxoguanine469.5OGG1, GSTT1, GSTM1
41cotinine46 2510.5OGG1, GSTT1, GSTM1
42benzene469.5OGG1, GSTM1, GSTT1
43acetone469.5GSTT1, GSTM1
44agarose469.5GSTM1, GSTT1, OGG1
45rsai469.3GSTM1, GSTT1
46manganese superoxide468.7GSTM1, GSTT1, OGG1, SOD3
47malondialdehyde468.7GSTM1, GSTT1, OGG1, SOD3
48folate468.7SOD3, GSTM1, GSTT1, OGG1
49ascorbic acid46 259.7GSTM1, SOD3, GSTT1, OGG1
50oxygen46 259.4OGG1, SOD3, GSTT1, GSTM1

GO Terms for genes affiliated with Asbestosis

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17Gene Ontology
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Cellular components related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1kinesin complexGO:0058719.3KIF5A, KIF18A
2cytosolGO:0058297.3KIF5A, KIF18A, GSTT1, GSTM1, SOD3

Biological processes related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:19016879.7GSTT1, GSTM1
2glutathione metabolic processGO:0067499.7GSTT1, GSTM1
3xenobiotic metabolic processGO:0068059.6GSTT1, GSTM1
4microtubule-based movementGO:0070189.3KIF5A, KIF18A
5antigen processing and presentation of exogenous peptide antigen via MHC class IIGO:0198869.2KIF18A, KIF5A
6metabolic processGO:0081529.0KIF5A, KIF18A

Molecular functions related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1glutathione transferase activityGO:0043649.6GSTT1, GSTM1
2microtubule bindingGO:0080178.5OGG1, KIF5A, KIF18A

Products for genes affiliated with Asbestosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Asbestosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet