MCID: ASB001
MIFTS: 52

Asbestosis malady

Summaries for Asbestosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Asbestosis is a chronic inflammatory and fibrotic medical condition affecting the parenchymal tissue of... more...

MalaCards: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to lung cancer and pulmonary fibrosis. An important gene associated with Asbestosis is GSTT1 (glutathione S-transferase theta 1), and among its related pathways are Aflatoxin B1 metabolism and superoxide radicals degradation. The compounds estrogen and gssg have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone, and related mouse phenotypes are homeostasis/metabolism and normal.

Aliases & Classifications for Asbestosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

asbestosis 8 42 10 44 60
idiopathic interstitial pneumonitis - from asbestos exposure 42
pulmonary fibrosis - from asbestos exposure 42
asbestosis nos 8


External Ids:

Disease Ontology8 DOID:10320
MeSH34 D001195
NCIt39 C84573
ICD9CM27 501

Related Diseases for Asbestosis

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17GeneCards, 18GeneDecks
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Diseases related to Asbestosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.1TIMP1, OGG1, SOD2, MSLN, ENO2, GSTM1
2pulmonary fibrosis30.5TIMP1, SOD3, MPO, TGFA
3malignant mesothelioma30.4MSLN, THBD, MUC1, WT1, SOD2, CALB2
4adenocarcinoma30.3MUC1, WT1, SOD2, OGG1, CALB2, TIMP1
5lung adenocarcinoma30.3GSTM1, SERPINA1, MSLN, THBD, MUC1, SOD2
6tuberculosis30.3SERPINA1
7peritonitis30.0MPO
8malignant pleural mesothelioma30.0MSLN, CALB2
9benign mesothelioma30.0MSLN, THBD, WT1, CALB2
10pneumonia30.0SOD3, MPO, MUC1, SERPINA1, GSTM1
11stomach cancer30.0TIMP1, SOD2, MUC1, SERPINA1, GSTP1, TGFA
12lupus erythematosus29.8THBD
13non-hodgkin lymphoma29.8OGG1, SOD2, GSTM1, GSTT1
14leukemia29.8OGG1, WT1, MPO, ALAS2, GSTM1, GSTT1
15sarcoma29.8CALB2, SOD2, WT1, MUC1, ENO2, GSTM1
16silicosis10.6
17pneumoconiosis10.4
18idiopathic pulmonary fibrosis10.2
19pleural cancer10.2
20pulmonary tuberculosis10.0
21benign pleural mesothelioma10.0
22berylliosis10.0
23laryngitis10.0
24asbestos intoxication10.0
25infertility10.0GSTT1
26cerebrovascular disease10.0SOD3
27thymoma10.0CALB2
28primary open angle glaucoma10.0GSTM1
29leydig cell tumor10.0CALB2
30stroke, ischemic10.0THBD
31bronchitis10.0SERPINA1
32eclampsia10.0THBD
33vitiligo10.0G6PD
34inflammatory bowel disease10.0MPO
35migraine10.0GSTM1
36schizophrenia10.0CALB2
37esophagitis10.0SOD2
38essential hypertension10.0THBD
39esophageal cancer10.0GSTP1
40hemochromatosis10.0SERPINA1
41thyroid cancer10.0GSTM1, GSTT1
42medulloblastoma10.0ENO2
43diabetic retinopathy10.0SOD2
44neuropathy10.0SOD2
45neuroblastoma10.0ENO2
46alpha 1-antitrypsin deficiency10.0SERPINA1
47down syndrome10.0SOD2
48glaucoma10.0GSTP1
49insulin resistance10.0SOD3
50graves' disease10.0MPO

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Clinical Features for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Asbestosis

Drug clinical trials:

Search ClinicalTrials for Asbestosis

Search NIH Clinical Center for Asbestosis

Search CenterWatch for Asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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32MalaCards
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MalaCards organs/tissues related to Asbestosis:

32
Lung, Testes, Bone, Liver, Bone marrow, Testis, T cells, Colon, Nk cells

Animal Models for Asbestosis or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Asbestosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1GSTT1, ALAS2, THBD, KIF5A, G6PD, SOD3
2MP:00028738.7OGG1, SOD3, WT1, MUC1, KIF5A, THBD

Publications for Asbestosis

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Sources:
50PubMed
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Articles related to Asbestosis:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
2
Inducible nitric oxide synthase genetic polymorphism and risk of asbestosis. (21660141)
2011
3
Mortality trends in asbestosis, extrinsic allergic alveolitis and sarcoidosis in England and Wales. (21704503)
2011
4
Asbestosis and mesothelioma among British asbestos workers (1971-2005). (20957726)
2010
5
LC-ESI-MS/MS method for oxidative stress multimarker screening in the exhaled breath condensate of asbestosis/silicosis patients. (21386209)
2010
6
Asbestosis mortality in the USA: facts and predictions. (19017689)
2009
7
Asbestosis mortality surveillance in the United States, 1970-2004. (18686715)
2008
8
A fuzzy-classifier using a marker panel for the detection of lung cancers in asbestosis patients. (17649786)
2007
9
The additional risk of malignant mesothelioma in former workers and residents of Wittenoom with benign pleural disease or asbestosis. (16169910)
2005
10
Asbestos, asbestosis, and lung cancer: a critical assessment of the epidemiological evidence. (15860721)
2005
11
Mortality, morbidity, and asbestosis in New Zealand: the hidden legacy of asbestos exposure. (15570336)
2004
12
Asbestosis and idiopathic pulmonary fibrosis: comparison of thin-section CT features. (14576443)
2003
13
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
14
Progression of asbestosis predicts lung cancer. (9631787)
1998
15
The molecular epidemiology of oncoproteins. Serum p53 protein in patients with asbestosis. (8598138)
1996
16
Serum oncoproteins in asbestosis patients. (7497643)
1995
17
Asbestos exposure and asbestosis: clarifying terminology and avoiding confusion. (8786585)
1995
18
Asbestos fiber analysis in seven asbestosis cases. (8117151)
1994
19
Diagnosis of asbestosis by a time expanded wave form analysis, auscultation and high resolution computed tomography: a comparative study. (8511731)
1993
20
Severity of pulmonary asbestosis as classified by International Labour Organisation profusion of irregular opacities in 8749 asbestos-exposed American workers. Those who never smoked compared with those who ever smoked. (1739361)
1992
21
Pleural plaques do not predict asbestosis: high-resolution computed tomography and pathology study. (2047383)
1991
22
X-ray films and asbestosis. (2791698)
1989
23
A clinical diagnostic model for the assessment of asbestosis: a new algorithmic approach. (3184241)
1988
24
Significance of finger clubbing in asbestosis. (3433234)
1987
25
Prevalence of radiographic asbestosis in crocidolite miners and millers at Wittenoom, Western Australia. (3013280)
1986
26
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
27
Asymmetric rapidly progressive lung fibrosis: a cause of pseudotumour in asbestosis. (3986147)
1985
28
Pulmonary bombesin in experimentally induced asbestosis in rats. (3996331)
1985
29
Asbestosis: inhalation disease of the lungs. (3975053)
1985
30
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
31
Lack of correlation between serum angiotensin-converting enzyme levels and asbestosis in man, sheep and guinea-pig. (6308362)
1983
32
Asbestosis and the serratus anterior muscle. (6854665)
1983
33
A comparative study of mesothelioma and asbestosis using computed tomography and conventional chest radiography. (6856860)
1983
34
The relation of asbestos burden to asbestosis and lung cancer. (6674859)
1983
35
Asbestosis in long-term employees of an Ontario asbestos-cement factory. (7081805)
1982
36
Correlation of asbestos bodies and fibers in lungs of subjects with and without asbestosis. (6188199)
1982
37
Criteria for the diagnosis of asbestosis and considerations in the attribution of lung cancer and mesothelioma to asbestos exposure. Prepared by the Medical Advisory Panel to the Asbestos International Association. (7068247)
1982
38
Asbestosis. (7465792)
1980
39
The relationship between asbestosis and bronchial cancer. (7408547)
1980
40
Early evidence of asbestosis. (435866)
1979
41
Electrocardiographic signs of cor pulmonale in asbestosis. (457289)
1979
42
Test and teach. Number eighteen: asbestosis. (530748)
1979
43
Sputum cytology of asbestosis patients. (734389)
1978
44
Computer tomography in the evaluation of pulmonary asbestosis. Preliminary experiences with the EMI general purpose scanner. (970205)
1976
45
Letter: Pleural effusion in asbestosis. (4818905)
1974
46
Asbestosis following brief exposure in cigarette filter manufacture. (5018998)
1972
47
Immunoelectrophoretic pattern changes in asbestosis. (5574684)
1971
48
Asbestosis. (5572879)
1971
49
Asbestosis in South African asbestos miners. (5489822)
1970
50
Asbestosis in Rhodesia. (5350834)
1969

Genetic Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 53Reactome, 29KEGG
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Compounds for genes affiliated with Asbestosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Asbestosis according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CALB2
2gssg4410.3G6PD
3methylchloride4410.2GSTP1, GSTM1, GSTT1
4butyrate4410.2ALAS2, SOD2, CALB2
5cumene hydroperoxide4410.1G6PD, GSTM1, GSTT1, GSTP1
61-hydroxypyrene4410.1GSTM1, GSTP1, GSTT1, OGG1
7manganese superoxide4410.1GSTT1, SOD2, SOD3, GSTP1
88-oxo-dg4410.0GSTT1, GSTM1, SOD2, OGG1
9ethylene oxide4410.0OGG1, GSTM1, GSTT1
10s-phenylmercapturic acid4410.0GSTM1, GSTT1, GSTP1
118-oxoguanine4410.0GSTM1, OGG1, SOD2, GSTT1
12heparin44 28 11 2412.9TIMP1, SOD3, SERPINA1, MPO
13acetone449.8GSTP1, GSTT1, GSTM1, MUC1, G6PD
14hypoxanthine44 11 2411.8SOD2, G6PD, MPO, ENO2
15nadph44 2410.8CALB2, OGG1, SOD3, SOD2, G6PD
16alpha tocopherol449.8G6PD, SOD2, GSTM1
17h2o2449.7TGFA, THBD, MPO, G6PD, OGG1
18serine449.7WT1, TIMP1, MPO, SOD3, G6PD
19oxaliplatin44 49 1111.6MPO, GSTM1, GSTT1, TGFA, GSTP1
20creatinine449.6WT1, THBD, SERPINA1, GSTM1, GSTT1, TGFA
21agarose449.6SERPINA1, OGG1, MUC1, THBD, GSTT1, GSTM1
22b 723449.6WT1, THBD, MSLN, MUC1, CALB2
234-hydroxynonenal44 2410.5SOD2, GSTP1, GSTM1, MPO, G6PD
24carboplatin44 49 1111.5GSTP1, GSTM1, ENO2, MPO, GSTT1
25oxygen44 2410.5MPO, MUC1, SERPINA1, ALAS2, OGG1, GSTM1
26etoposide44 49 59 1112.5TIMP1, SOD2, GSTP1, TGFA, WT1
27cyclophosphamide44 49 1111.5MPO, G6PD, GSTP1, THBD, GSTM1, GSTT1
28vitamin d449.5GSTM1, THBD, WT1, SOD2, SOD3, TGFA
29valine449.4THBD, GSTP1, SOD2, GSTM1, GSTT1, G6PD
30azathioprine44 49 2 1112.4G6PD, GSTM1, GSTP1, THBD, TGFA, TIMP1
31malondialdehyde449.2OGG1, GSTM1, ENO2, MPO, G6PD, SOD2
32doxorubicin44 49 1111.2G6PD, WT1, SOD2, GSTT1, GSTM1, GSTP1
335fluorouracil449.1GSTM1, TGFA, GSTP1, SOD2, MPO, MUC1
34dmso449.0MUC1, MPO, ENO2, SOD2, OGG1, THBD
35hyaluronic acid44 2410.0MUC1, TIMP1, ENO2, MSLN, THBD, WT1
36methotrexate44 49 1110.9GSTP1, ENO2, MUC1, SOD2, TIMP1, TGFA
37actinomycin d448.9MUC1, THBD, GSTP1, TIMP1, TGFA, G6PD
38glutamine448.8TGFA, SOD2, ALAS2, OGG1, TIMP1, ENO2
39cisplatin44 49 59 1111.8SOD2, GSTT1, MUC1, ENO2, GSTM1, G6PD
40arginine448.7SOD3, TIMP1, GSTP1, GSTT1, ALAS2, THBD
41lactate448.6G6PD, MPO, ENO2, GSTM1, GSTP1, TGFA
42ascorbic acid44 249.6SERPINA1, GSTP1, TGFA, GSTT1, GSTM1, OGG1
43progesterone44 59 28 11 2412.5SERPINA1, ENO2, TGFA, THBD, TIMP1, MUC1
44testosterone44 59 11 2411.5TGFA, SOD2, WT1, G6PD, MUC1, ENO2
45folate448.4GSTM1, THBD, MUC1, G6PD, SOD2, SOD3
46cysteine448.3SERPINA1, GSTM1, SOD3, GSTP1, THBD, TGFA
47dopamine44 28 11 2411.3ENO2, GSTM1, GSTP1, TGFA, CALB2, OGG1
48nitric oxide44 11 2410.2THBD, SERPINA1, MUC1, ENO2, MPO, WT1
49vegf448.0MSLN, GSTP1, ENO2, MPO, SOD2, SOD3
50paraffin448.0MUC1, SERPINA1, ENO2, GSTP1, TGFA, THBD

GO Terms for genes affiliated with Asbestosis

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16Gene Ontology
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Biological processes related to Asbestosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1oxygen homeostasisGO:03236410.1SOD2, ALAS2
2glutathione derivative biosynthetic processGO:190168710.1GSTM1, GSTT1, GSTP1
3removal of superoxide radicalsGO:01943010.0MPO, SOD2, SOD3
4erythrocyte maturationGO:04324910.0G6PD, TIMP1
5response to hypoxiaGO:0016669.8ALAS2, SERPINA1, SOD2, SOD3
6glutathione metabolic processGO:0067499.7GSTP1, GSTT1, GSTM1, G6PD, SOD2
7blood coagulationGO:0075969.4SERPINA1, THBD, KIF18A, KIF5A, TIMP1
8response to drugGO:0424939.2TGFA, GSTT1, SOD2, OGG1
9negative regulation of apoptotic processGO:0430669.0TIMP1, WT1, MPO, GSTP1, TGFA

Molecular functions related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:00478410.1SOD2, SOD3
2glutathione transferase activityGO:0043649.8GSTP1, GSTT1, GSTM1
3protein bindingGO:0055157.0MUC1, G6PD, WT1, SOD3, OGG1, TIMP1

Products for genes affiliated with Asbestosis

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Sources for Asbestosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet