MCID: ASB001
MIFTS: 42

Asbestosis malady

Categories: Rare diseases, Respiratory diseases

Aliases & Classifications for Asbestosis

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Aliases & Descriptions for Asbestosis:

Name: Asbestosis 11 46 13 48 37 66
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 46
 
Pulmonary Fibrosis - from Asbestos Exposure 46

Classifications:



External Ids:

Disease Ontology11 DOID:10320
ICD1028 J61
ICD9CM30 501
MeSH37 D001195
NCIt43 C84573

Summaries for Asbestosis

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Wikipedia:69 Asbestosis is a chronic inflammatory and scarring disease affecting the tissue of the lungs. People with... more...

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to berylliosis and asbestos intoxication. An important gene associated with Asbestosis is SOD3 (Superoxide Dismutase 3, Extracellular), and among its related pathways are Folate Metabolism and Busulfan Pathway, Pharmacodynamics. Affiliated tissues include lung, testes and neutrophil, and related mouse phenotype neoplasm.

Disease Ontology:11 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1berylliosis24.3CAT, GSTM1, GSTP1, GSTT1, IL6, KIF18A
2asbestos intoxication11.1
3lung cancer10.6
4oral pharyngeal disorders10.5GSTM1, GSTT1
5levic stefanovic nikolic syndrome10.5GSTM1, GSTT1
6hallucinogen abuse10.5SOD2, SOD3
7emery-dreifuss muscular dystrophy, dominant type10.5GSTM1, GSTT1
8ulcerative stomatitis10.4GSTM1, GSTT1
9myasthenia gravis, limb-girdle10.4GSTM1, GSTT1
10silicosis10.4
11orbital cyst10.4GSTM1, GSTT1
12cavernous hemangioma of colon10.3GSTM1, GSTT1
13renal artery disease10.3GSTM1, IL6
14transient neonatal thrombocytopenia10.3CAT, SOD3
15prediabetes syndrome10.3CAT, SOD2
16pseudoretinitis pigmentosa10.3CAT, SOD2
17abdominal chemodectomas with cutaneous angiolipomas10.3IL6, SERPINA1
18mast syndrome10.2SOD2, SOD3
19pulmonary fibrosis10.2
20sweat gland cancer10.2IL6, SERPINA1
21pneumoconiosis10.2
22chorioretinitis10.2GSTT1, IL6
23oral lichen planus10.1GSTM1, GSTP1, GSTT1
24adenocarcinoma10.1
25cervical cancer, somatic10.1GSTM1, GSTP1, GSTT1
26tuberculosis10.0
27kidney angiomyolipoma10.0IL6, SOD2
28amelogenesis imperfecta10.0GSTM1, IL6
29gender identity disorder10.0GSTM1, GSTT1, IL6
30cervix carcinoma10.0GSTM1, GSTT1, IL6
31pneumonia10.0
32interstitial lung disease10.0
33pulmonary tuberculosis9.9
34lung disease9.9
35breast epithelioid hemangioma9.9CAT, SOD2
36stomach cancer9.8
37laryngitis9.8
38peritonitis9.8
39hypocalciuric hypercalcemia, type i9.8GSTM1, GSTT1, IL6
40laryngeal benign neoplasm9.8GSTM1, GSTP1, GSTT1, OGG1
41hidrocystoma9.8GSTM1, GSTP1, GSTT1, OGG1
42asbestosis9.7GSTM1, GSTT1, IL6, OGG1
43diplegia of upper limb9.7CAT, GSTM1, GSTT1, SOD2
44systemic lupus erythematosus9.7
45hodgkin lymphoma9.7
46multiple myeloma9.7
47insulin-like growth factor i9.7
48temporal arteritis9.7
49gastric cancer9.7
50leukemia9.7

Comorbidity relations with Asbestosis via Phenotypic Disease Network (PDN):


Prostate CancerCoronary Artery Disease
Deficiency AnemiaIschemic Heart Disease
Familial Atrial FibrillationProstatic Hypertrophy
Respiratory FailureHeart Disease
Postinflammatory Pulmonary FibrosisChronic Pulmonary Heart Disease
BronchitisIntermediate Coronary Syndrome

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1XenonPhase 062

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed PopulationCompletedNCT02076672Phase 2
2Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
3Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early DiagnosisRecruitingNCT02280343
4Developing Optimal Parameters for Hyperpolarized Noble Gas and Inert Fluorinated Gas MRI of Lung DisordersNot yet recruitingNCT02748798Phase 0

Search NIH Clinical Center for Asbestosis


Cochrane evidence based reviews: asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

34
Lung, Testes, Neutrophil, Nk cells, T cells, Testis, Colon

Animal Models for Asbestosis or affiliated genes

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MGI Mouse Phenotypes related to Asbestosis:

39
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.8CAT, GSTP1, IL6, OGG1, SOD2

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 520)
idTitleAuthorsYear
1
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. (26071911)
2015
2
Asbestosis and other pulmonary fibrosis in asbestos-exposed workers: high-resolution CT features with pathological correlations. (26334510)
2015
3
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
4
Bronchoalveolar neutrophilia inversely correlates with DLCO at diagnosis in asbestosis but not lung function decline at 1 year. (23825766)
2013
5
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
6
LC-ESI-MS/MS method for oxidative stress multimarker screening in the exhaled breath condensate of asbestosis/silicosis patients. (21386209)
2010
7
Serum growth factors in asbestosis patients. (19283526)
2009
8
Pleural plaques and asbestosis: dose- and time-response relationships based on HRCT data. (19129281)
2009
9
Asbestosis: demonstration of distinctive interstitial fibroelastosis: a pilot study. (19751905)
2009
10
Radiographic readings for asbestosis: misuse of science--validation of the ILO classification. (17154406)
2007
11
In vivo bioassays of acute asbestosis and its correlation with ESR spectroscopy and imaging in redox status. (12162455)
2002
12
Asbestosis in Malaysia: report on first two cases. (11045065)
1999
13
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
14
Pulmonary function of nonsmoking female asbestos workers without radiographic signs of asbestosis. (9709994)
1998
15
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
16
Clinical predictors of mortality from asbestosis in the North American Insulator Cohort, 1981 to 1991. (9230732)
1997
17
Professor Matthew Stewart: asbestosis research 1929-1934. (9327084)
1997
18
The glutathione S-transferase theta and mu deletion polymorphisms in asbestosis. (9055949)
1997
19
Carcinosarcoma of lung associated with asbestosis. (8575744)
1995
20
Computed tomography in the early detection of asbestosis. (8398855)
1993
21
Lymphocyte B and T cell subsets in peripheral blood from patients with asbestosis. (8382078)
1993
22
Asbestos, asbestosis, and lung cancer. (8248104)
1993
23
Asbestosis as a precursor of asbestos related lung cancer: results of a prospective mortality study. (2025587)
1991
24
Recent advances in the pathogenesis and clinical assessment of mineral dust pneumoconioses: asbestosis, silicosis and coal pneumoconiosis. (2691279)
1989
25
Asbestos-related pleural disease and asbestosis: a comparison of CT and chest radiography. (3257311)
1988
26
Current issues regarding the pathobiology of asbestosis: a chronologic perspective. (3054134)
1988
27
A clinical diagnostic model for the assessment of asbestosis: a new algorithmic approach. (3184241)
1988
28
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
29
The association of carcinoma, tuberculosis, asbestosis, and fibrosing alveolitis of the lung: report of a case and review of the literature. (3679907)
1987
30
Immunogenetic factors as determinants of asbestosis. (3108592)
1987
31
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
32
Asbestos bodies in carcinoma of colon in an insulation worker with asbestosis. (4057514)
1985
33
Asbestosis. (4073386)
1985
34
Asbestosis criteria. (6546497)
1984
35
Asbestos related diseases without asbestosis. (6223683)
1983
36
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
37
Incipient cases of asbestosis in a Kenyan factory. (6671435)
1983
38
The development of asbestosis. (18748527)
1980
39
UK Naval Dockyards asbestosis study: survey of the sample population aged 50-59 years. (508640)
1979
40
Early evidence of asbestosis. (435866)
1979
41
Elimination of asbestosis. (651728)
1978
42
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. (872451)
1977
43
Diagnosis of asbestosis by transbronchial biopsy. A method to facilitate demonstration of ferruginous bodies. (848793)
1977
44
Proceedings: HL-A type and asbestosis. (1181698)
1975
45
Chest auscultation in the diagnosis of pulmonary asbestosis. (4693173)
1973
46
Asbestosis-diaphragmatic pleural calcification. (18730864)
1972
47
Asbestosis claim succeeds. (4193585)
1970
48
The radiology of asbestosis. (5798718)
1969
49
Correlation between the electrocardiogram and radiological picture in 29 cases of asbestosis. (5365918)
1969
50
SILICO-ANTHRACOSIS PRESENTING CURIOUS BODIES SIMILAR TO THOSE IN ASBESTOSIS. (20776780)
1932

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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Pathways related to Asbestosis according to GeneCards Suite gene sharing:

(show all 13)
idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.7CAT, SOD3
2
Show member pathways
9.5GSTM1, GSTP1
39.5CAT, SOD2
49.5GSTP1, GSTT1
59.2CAT, SOD2, SOD3
6
Show member pathways
9.2GSTM1, GSTP1, GSTT1
7
Show member pathways
9.2GSTM1, GSTP1, GSTT1
89.2GSTM1, GSTP1, GSTT1
99.2GSTM1, GSTP1, GSTT1
10
Show member pathways
8.7CAT, IL6, SOD2
11
Show member pathways
8.6CAT, GSTP1, SOD2, SOD3
12
Show member pathways
8.4CAT, IL6, SOD2, SOD3
13
Show member pathways
7.8CAT, GSTP1, IL6, SOD2, SOD3

GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.8CAT, GSTP1, IL6, SERPINA1, SOD3

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1removal of superoxide radicalsGO:001943010.3SOD2, SOD3
2response to cadmium ionGO:004668610.0CAT, SOD2
3response to hyperoxiaGO:005509310.0CAT, SOD2
4glutathione derivative biosynthetic processGO:19016879.9GSTM1, GSTP1, GSTT1
5negative regulation of fibroblast proliferationGO:00481479.9GSTP1, SOD2
6acute inflammatory responseGO:00025269.8IL6, OGG1
7acute-phase responseGO:00069539.8IL6, SERPINA1
8response to coldGO:00094099.7IL6, SOD2
9response to radiationGO:00093149.7CAT, OGG1, SOD2
10negative regulation of fat cell differentiationGO:00455999.6IL6, SOD2
11response to electrical stimulusGO:00516029.6IL6, SOD2
12positive regulation of nitric oxide biosynthetic processGO:00454299.6IL6, SOD2
13cellular oxidant detoxificationGO:00988699.5CAT, GSTP1, GSTT1
14response to L-ascorbic acidGO:00335919.5CAT, GSTP1, SOD2
15response to oxidative stressGO:00069799.3CAT, OGG1, SOD2, SOD3
16response to amino acidGO:00432009.3GSTP1, IL6
17response to estradiolGO:00323559.3CAT, GSTP1, OGG1
18response to hypoxiaGO:00016669.1CAT, SOD2, SOD3
19response to reactive oxygen speciesGO:00003029.1CAT, GSTP1, SOD2, SOD3
20response to ethanolGO:00454719.0CAT, GSTP1, OGG1
21response to nutrient levelsGO:00316678.9GSTP1, IL6, SOD2
22glutathione metabolic processGO:00067498.9GSTM1, GSTP1, GSTT1, SOD2
23agingGO:00075688.7CAT, IL6, OGG1, SOD2
24response to drugGO:00424938.1CAT, IL6, OGG1, SOD2
25negative regulation of apoptotic processGO:00430667.9CAT, GSTP1, IL6, OGG1, SOD2

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-dependent microtubule motor activity, plus-end-directedGO:000857410.1KIF18A, KIF5A
2superoxide dismutase activityGO:000478410.1SOD2, SOD3
3glutathione bindingGO:004329510.1GSTM1, GSTP1
4glutathione peroxidase activityGO:00046029.8GSTP1, GSTT1
5glutathione transferase activityGO:00043649.3GSTM1, GSTP1, GSTT1
6microtubule bindingGO:00080179.3KIF18A, KIF5A, OGG1

Sources for Asbestosis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet