MCID: ASB001
MIFTS: 52

Asbestosis malady

Summaries for Asbestosis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Asbestosis is a chronic inflammatory and fibrotic medical condition affecting the parenchymal tissue of... more...

MalaCards: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to lung cancer and pulmonary fibrosis. An important gene associated with Asbestosis is GSTT1 (glutathione S-transferase theta 1), and among its related pathways are Aflatoxin B1 metabolism and superoxide radicals degradation. The compounds estrogen and gssg have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and bone marrow, and related mouse phenotypes are homeostasis/metabolism and normal.

Aliases & Classifications for Asbestosis

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8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt, 27ICD9CM
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Aliases & Descriptions:

asbestosis 8 42 10 44 60
idiopathic interstitial pneumonitis - from asbestos exposure 42
pulmonary fibrosis - from asbestos exposure 42
asbestosis nos 8


External Ids:

Disease Ontology8 DOID:10320
MeSH34 D001195
NCIt39 C84573
ICD9CM27 501

Related Diseases for Asbestosis

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17GeneCards, 18GeneDecks
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Diseases related to Asbestosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1lung cancer31.1TIMP1, OGG1, SOD2, MSLN, ENO2, GSTM1
2pulmonary fibrosis30.5TIMP1, SOD3, MPO, TGFA
3malignant mesothelioma30.4MSLN, THBD, MUC1, WT1, SOD2, CALB2
4adenocarcinoma30.3MUC1, WT1, SOD2, OGG1, CALB2, TIMP1
5lung adenocarcinoma30.3GSTM1, SERPINA1, MSLN, THBD, MUC1, SOD2
6tuberculosis30.3SERPINA1
7peritonitis30.0MPO
8malignant pleural mesothelioma30.0MSLN, CALB2
9benign mesothelioma30.0MSLN, THBD, WT1, CALB2
10pneumonia30.0SOD3, MPO, MUC1, SERPINA1, GSTM1
11stomach cancer30.0TIMP1, SOD2, MUC1, SERPINA1, GSTP1, TGFA
12lupus erythematosus29.8THBD
13non-hodgkin lymphoma29.8OGG1, SOD2, GSTM1, GSTT1
14leukemia29.8OGG1, WT1, MPO, ALAS2, GSTM1, GSTT1
15sarcoma29.8CALB2, SOD2, WT1, MUC1, ENO2, GSTM1
16silicosis10.6
17pneumoconiosis10.4
18idiopathic pulmonary fibrosis10.2
19pleural cancer10.2
20pulmonary tuberculosis10.0
21benign pleural mesothelioma10.0
22berylliosis10.0
23laryngitis10.0
24asbestos intoxication10.0
25infertility10.0GSTT1
26cerebrovascular disease10.0SOD3
27thymoma10.0CALB2
28primary open angle glaucoma10.0GSTM1
29leydig cell tumor10.0CALB2
30stroke, ischemic10.0THBD
31bronchitis10.0SERPINA1
32eclampsia10.0THBD
33vitiligo10.0G6PD
34inflammatory bowel disease10.0MPO
35migraine10.0GSTM1
36schizophrenia10.0CALB2
37esophagitis10.0SOD2
38essential hypertension10.0THBD
39esophageal cancer10.0GSTP1
40hemochromatosis10.0SERPINA1
41thyroid cancer10.0GSTM1, GSTT1
42medulloblastoma10.0ENO2
43diabetic retinopathy10.0SOD2
44neuropathy10.0SOD2
45neuroblastoma10.0ENO2
46alpha 1-antitrypsin deficiency10.0SERPINA1
47down syndrome10.0SOD2
48glaucoma10.0GSTP1
49insulin resistance10.0SOD3
50graves' disease10.0MPO

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Clinical Features for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Asbestosis

Drug clinical trials:

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Search NIH Clinical Center for Asbestosis

Search CenterWatch for Asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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32MalaCards
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MalaCards organs/tissues related to Asbestosis:

32
Lung, Testes, Bone marrow, Bone, Colon, Liver, Testis, Nk cells, T cells

Animal Models for Asbestosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Asbestosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053769.1GSTT1, ALAS2, THBD, KIF5A, G6PD, SOD3
2MP:00028738.7OGG1, SOD3, WT1, MUC1, KIF5A, THBD

Publications for Asbestosis

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Sources:
50PubMed
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Articles related to Asbestosis:

(show top 50)    (show all 494)
idTitleAuthorsYear
1
YKL-40 and Mesothelin in the Blood of Patients with Malignant Mesothelioma, Lung Cancer and Asbestosis. (24324091)
2013
2
Pathology of asbestosis- An update of the diagnostic criteria: Report of the asbestosis committee of the college of american pathologists and pulmonary pathology society. (20196674)
2010
3
Information from your family doctor. Asbestosis: what you should know. (17375515)
2007
4
Silico-asbestosis that responded to steroid therapy. (16946575)
2006
5
Asbestos lung residue and asbestosis risk. (15933073)
2005
6
Commentary regarding the article by Fischer et al.: Fibre years, pulmonary asbestos burden and asbestosis. Int. J. Hyg. Environ. Health 205, 245-248 (2002). (12872536)
2003
7
Radiographic (ILO) readings predict arterial oxygen desaturation during exercise in subjects with asbestosis. (12598668)
2003
8
Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease. (10543275)
1999
9
Pulmonary asbestosis associated to pleural non-Hodgkin lymphoma. (10228504)
1999
10
Pulmonary function of nonsmoking female asbestos workers without radiographic signs of asbestosis. (9709994)
1998
11
Magnetic resonance imaging of the thorax in the evaluation of asbestosis. (9543293)
1998
12
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
13
CT quantification of interstitial fibrosis in patients with asbestosis: a comparison of two methods. (7998570)
1995
14
Does asbestos or asbestosis cause carcinoma of the lung? (7892835)
1994
15
An autopsy case of malignant mesothelioma associated with asbestosis. (7834080)
1994
16
Is there an association between pleural plaques and lung cancer without asbestosis? (8016601)
1994
17
Asbestos, asbestosis, and lung cancer. (8248104)
1993
18
Total lung capacity in asbestosis: a comparison of radiographic and body plethysmographic methods. (8427297)
1993
19
Asbestosis mortality in Italy. (8255259)
1993
20
Patterns of asbestosis in New Jersey. (1609815)
1992
21
The diagnosis of asbestosis. (1892281)
1991
22
Evidence for an amphibole asbestos threshold exposure for asbestosis assessed by autopsy in South African asbestos miners. (2281889)
1990
23
Relation between asbestosis and bronchial cancer in amphibole asbestos miners. (2550049)
1989
24
Current issues regarding the pathobiology of asbestosis: a chronologic perspective. (3054134)
1988
25
Different patterns of gas exchange response to exercise in asbestosis and idiopathic pulmonary fibrosis. (3169220)
1988
26
Roentgenographic underestimation of early asbestosis by International Labor Organization classification. Analysis of data and probabilities. (3359826)
1988
27
Enzyme activities of lung lavage in asbestosis. (2428541)
1986
28
Reduced killer cell activity of lymphocytes from patients with asbestosis. (3978049)
1985
29
Asbestosis and cryptogenic fibrosing alveolitis: a radiological and functional comparison. (6597709)
1984
30
A comparative study of mesothelioma and asbestosis using computed tomography and conventional chest radiography. (7100456)
1982
31
Surgical and pathologic aspects of asbestosis. (7292052)
1981
32
Review of lung function data in 195 patients with asbestosis of the lung. (7364483)
1980
33
Current views on pathological aspects of asbestosis (the unresolved questions and problems). (7239641)
1980
34
Asbestosis among maintenance workers in the chemical industry and in oil refinery workers. (6971805)
1980
35
The pathogenesis of pleural plaques and pulmonary asbestosis: possibilities and impossibilities. (7002573)
1980
36
The value of nonradiological indicators in the early diagnosis of asbestosis. (7228306)
1980
37
Absence of synergism between exposure to asbestos and cigarette smoking in asbestosis. (464386)
1979
38
Asbestosis and mesothelioma on the Rhodesia railways. (455417)
1979
39
Asbestosis and mesothelioma [proceedings]. (435375)
1979
40
Radiographic and physiological findings in patients with asbestosis. (734388)
1978
41
An early case of asbestosis. Case history. (249383)
1978
42
Asbestosis. (73933)
1977
43
Serial pulmonary function tests in patients with asbestosis. (841533)
1977
44
Pulmonary asbestosis and autoimmunity. (766909)
1976
45
The visceral pleura in asbestosis. (1253767)
1976
46
Asbestosis. (993870)
1976
47
Chest auscultation in the diagnosis of pulmonary asbestosis. (4693173)
1973
48
Caplan's syndrome in association with asbestosis. Report of a case. (5161827)
1971
49
Serum proteins and amino acids in asbestosis. (4324946)
1971
50
Asbestosis and neoplastic disorders of the hematopoietic system. (4984519)
1970

Genetic Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asbestosis

Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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Sources:
37NCBI BioSystems Database, 12EMD Millipore, 49PharmGKB, 53Reactome, 29KEGG
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Compounds for genes affiliated with Asbestosis

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Sources:
44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 49PharmGKB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Asbestosis according to GeneCards/GeneDecks:

(show top 50)    (show all 162)
idCompoundScoreTop Affiliating Genes
1estrogen4410.6CALB2
2gssg4410.3G6PD
3methylchloride4410.2GSTP1, GSTM1, GSTT1
4butyrate4410.2ALAS2, SOD2, CALB2
5cumene hydroperoxide4410.1G6PD, GSTM1, GSTT1, GSTP1
61-hydroxypyrene4410.1GSTM1, GSTP1, GSTT1, OGG1
7manganese superoxide4410.1GSTT1, SOD2, SOD3, GSTP1
88-oxo-dg4410.0GSTT1, GSTM1, SOD2, OGG1
9ethylene oxide4410.0OGG1, GSTM1, GSTT1
10s-phenylmercapturic acid4410.0GSTM1, GSTT1, GSTP1
118-oxoguanine4410.0GSTM1, OGG1, SOD2, GSTT1
12heparin44 28 11 2412.9TIMP1, SOD3, SERPINA1, MPO
13acetone449.8GSTP1, GSTT1, GSTM1, MUC1, G6PD
14hypoxanthine44 11 2411.8SOD2, G6PD, MPO, ENO2
15nadph44 2410.8CALB2, OGG1, SOD3, SOD2, G6PD
16alpha tocopherol449.8G6PD, SOD2, GSTM1
17h2o2449.7TGFA, THBD, MPO, G6PD, OGG1
18serine449.7WT1, TIMP1, MPO, SOD3, G6PD
19oxaliplatin44 49 1111.6MPO, GSTM1, GSTT1, TGFA, GSTP1
20creatinine449.6WT1, THBD, SERPINA1, GSTM1, GSTT1, TGFA
21agarose449.6SERPINA1, OGG1, MUC1, THBD, GSTT1, GSTM1
22b 723449.6WT1, THBD, MSLN, MUC1, CALB2
234-hydroxynonenal44 2410.5SOD2, GSTP1, GSTM1, MPO, G6PD
24carboplatin44 49 1111.5GSTP1, GSTM1, ENO2, MPO, GSTT1
25oxygen44 2410.5MPO, MUC1, SERPINA1, ALAS2, OGG1, GSTM1
26etoposide44 49 59 1112.5TIMP1, SOD2, GSTP1, TGFA, WT1
27cyclophosphamide44 49 1111.5MPO, G6PD, GSTP1, THBD, GSTM1, GSTT1
28vitamin d449.5GSTM1, THBD, WT1, SOD2, SOD3, TGFA
29valine449.4THBD, GSTP1, SOD2, GSTM1, GSTT1, G6PD
30azathioprine44 49 2 1112.4G6PD, GSTM1, GSTP1, THBD, TGFA, TIMP1
31malondialdehyde449.2OGG1, GSTM1, ENO2, MPO, G6PD, SOD2
32doxorubicin44 49 1111.2G6PD, WT1, SOD2, GSTT1, GSTM1, GSTP1
335fluorouracil449.1GSTM1, TGFA, GSTP1, SOD2, MPO, MUC1
34dmso449.0MUC1, MPO, ENO2, SOD2, OGG1, THBD
35hyaluronic acid44 2410.0MUC1, TIMP1, ENO2, MSLN, THBD, WT1
36methotrexate44 49 1110.9GSTP1, ENO2, MUC1, SOD2, TIMP1, TGFA
37actinomycin d448.9MUC1, THBD, GSTP1, TIMP1, TGFA, G6PD
38glutamine448.8TGFA, SOD2, ALAS2, OGG1, TIMP1, ENO2
39cisplatin44 49 59 1111.8SOD2, GSTT1, MUC1, ENO2, GSTM1, G6PD
40arginine448.7SOD3, TIMP1, GSTP1, GSTT1, ALAS2, THBD
41lactate448.6G6PD, MPO, ENO2, GSTM1, GSTP1, TGFA
42ascorbic acid44 249.6SERPINA1, GSTP1, TGFA, GSTT1, GSTM1, OGG1
43progesterone44 59 28 11 2412.5SERPINA1, ENO2, TGFA, THBD, TIMP1, MUC1
44testosterone44 59 11 2411.5TGFA, SOD2, WT1, G6PD, MUC1, ENO2
45folate448.4GSTM1, THBD, MUC1, G6PD, SOD2, SOD3
46cysteine448.3SERPINA1, GSTM1, SOD3, GSTP1, THBD, TGFA
47dopamine44 28 11 2411.3ENO2, GSTM1, GSTP1, TGFA, CALB2, OGG1
48nitric oxide44 11 2410.2THBD, SERPINA1, MUC1, ENO2, MPO, WT1
49vegf448.0MSLN, GSTP1, ENO2, MPO, SOD2, SOD3
50paraffin448.0MUC1, SERPINA1, ENO2, GSTP1, TGFA, THBD

GO Terms for genes affiliated with Asbestosis

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16Gene Ontology
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Biological processes related to Asbestosis according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1oxygen homeostasisGO:03236410.1SOD2, ALAS2
2glutathione derivative biosynthetic processGO:190168710.1GSTM1, GSTT1, GSTP1
3removal of superoxide radicalsGO:01943010.0MPO, SOD2, SOD3
4erythrocyte maturationGO:04324910.0G6PD, TIMP1
5response to hypoxiaGO:0016669.8ALAS2, SERPINA1, SOD2, SOD3
6glutathione metabolic processGO:0067499.7GSTP1, GSTT1, GSTM1, G6PD, SOD2
7blood coagulationGO:0075969.4SERPINA1, THBD, KIF18A, KIF5A, TIMP1
8response to drugGO:0424939.2TGFA, GSTT1, SOD2, OGG1
9negative regulation of apoptotic processGO:0430669.0TIMP1, WT1, MPO, GSTP1, TGFA

Molecular functions related to Asbestosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1superoxide dismutase activityGO:00478410.1SOD2, SOD3
2glutathione transferase activityGO:0043649.8GSTP1, GSTT1, GSTM1
3protein bindingGO:0055157.0MUC1, G6PD, WT1, SOD3, OGG1, TIMP1

Products for genes affiliated with Asbestosis

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Sources for Asbestosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet