MCID: ASB001
MIFTS: 39

Asbestosis malady

Rare diseases, Respiratory diseases categories

Aliases & Classifications for Asbestosis

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Aliases & Descriptions for Asbestosis:

Name: Asbestosis 10 45 47 12 65 36
Idiopathic Interstitial Pneumonitis - from Asbestos Exposure 45
 
Pulmonary Fibrosis - from Asbestos Exposure 45
Asbestosis Nos 10


Classifications:



External Ids:

Disease Ontology10 DOID:10320
MeSH36 D001195
ICD9CM29 501
NCIt42 C84573

Summaries for Asbestosis

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Disease Ontology:10 A pneumoconiosis caused by inhalation and retention of asbestos fibers.

MalaCards based summary: Asbestosis, also known as idiopathic interstitial pneumonitis - from asbestos exposure, is related to pneumonia and lung cancer. An important gene associated with Asbestosis is GSTM1 (Glutathione S-Transferase Mu 1), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and Naphthalene metabolism. Affiliated tissues include lung, bone and testes, and related mouse phenotypes are tumorigenesis and homeostasis/metabolism.

Related Diseases for Asbestosis

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Diseases related to Asbestosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 69)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia30.4CAT, GSTM1, IL6
2lung cancer10.8
3mesothelioma10.7
4silicosis10.7
5pneumoconiosis10.5
6pulmonary fibrosis10.4
7adenocarcinoma10.4
8tuberculosis10.3
9pulmonary tuberculosis10.2
10cicatricial ectropion10.2SOD2, SOD3
11pyloric antrum cancer10.2GSTM1, GSTT1
12frontal lobe epilepsy10.2GSTM1, GSTT1
13mast syndrome10.2SOD2, SOD3
14ectodermal dysplasia10.2GSTM1, GSTT1
15levator syndrome10.2GSTM1, GSTT1
16ureter squamous cell carcinoma10.2IL6, MUC1
17sensory organ benign neoplasm10.2GSTM1, GSTT1
18mutiple parosteal osteochondromatous proliferations10.2GSTM1, GSTT1
19female reproductive organ cancer10.2IL6, MUC1
20papillary cystadenocarcinoma10.1GSTM1, GSTT1
21berylliosis10.1
22laryngitis10.1
23peritonitis10.1
24stomach cancer10.1
25usual interstitial pneumonia10.1
26asbestos intoxication10.1
27diffuse idiopathic pulmonary neuroendocrine cell hyperplasia10.1GSTM1, GSTT1
28childhood disintegrative disease10.1CAT, SOD2
29male genital organ vascular disease10.1GSTM1, GSTT1
30clear cell ependymoma10.1MUC1, SERPINA1
31macrocytic anemia10.1GSTM1, GSTT1, OGG1
32cystic kidney10.1MUC1, SERPINA1
33orbit rhabdomyosarcoma10.1GSTM1, GSTT1, SOD2
34malignant gastric germ cell tumor10.0MUC1, SERPINA1
35visceral heterotaxy10.0IL6, SERPINA1
36bardet-biedl syndrome 810.0IL6, SERPINA1
37atypical follicular adenoma10.0CAT, SOD2
38ureter adenocarcinoma10.0CAT, GSTM1, GSTT1
39duodenal benign neoplasm10.0IL6, MUC1
40poliomyelitis10.0MUC1, SERPINA1
41systemic lupus erythematosus10.0
42hodgkin lymphoma10.0
43multiple myeloma10.0
44insulin-like growth factor i10.0
45gastric cancer10.0
46leukemia10.0
47temporal arteritis10.0
48peritoneal mesothelioma10.0
49constrictive pericarditis10.0
50caplan's syndrome10.0

Graphical network of the top 20 diseases related to Asbestosis:



Diseases related to asbestosis

Symptoms for Asbestosis

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Drugs & Therapeutics for Asbestosis

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Drugs for Asbestosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1ArtichokeNutraceuticalPhase 28

Interventional clinical trials:

idNameStatusNCT IDPhase
1Investigation of the Anti-Cancer Activity of Artichoke Extract in an Asbestos-Exposed PopulationActive, not recruitingNCT02076672Phase 2
2Specialized Center of Research in Occupational and Immunologic Lung DiseaseCompletedNCT00005280
3Oscillation Mechanics of the Respiratory System Asbestos Exposed: Early DiagnosisRecruitingNCT02280343

Search NIH Clinical Center for Asbestosis


Cochrane evidence based reviews: Asbestosis

Genetic Tests for Asbestosis

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Anatomical Context for Asbestosis

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MalaCards organs/tissues related to Asbestosis:

33
Lung, Bone, Testes, Neutrophil, T cells, Nk cells, Testis

Animal Models for Asbestosis or affiliated genes

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MGI Mouse Phenotypes related to Asbestosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020067.3CAT, IL6, MUC1, OGG1, SOD2
2MP:00053766.3CAT, GSTM1, GSTT1, IL6, KIF5A, MUC1

Publications for Asbestosis

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Articles related to Asbestosis:

(show top 50)    (show all 505)
idTitleAuthorsYear
1
Pleural plaques in smoking-associated fibrosis and pulmonary asbestosis. (25999705)
2015
2
Systemic autoimmune disease in asbestosis rapidly responding to anti-interleukin-1beta antibody canakinumab: a case report. (26071911)
2015
3
Reply: asbestos, asbestosis, smoking, and lung cancer: study bias and confounding issues that complicate the interpretation of the results. (24381998)
2014
4
Inter-reader agreement in HRCT detection of pleural plaques and asbestosis in participants with previous occupational exposure to asbestos. (25286915)
2014
5
Asbestosis in Louisiana: a descriptive review and demographic analysis of hospitalizations for abestosis, 1999-2009. (22324095)
2011
6
Asbestosis and mesothelioma among British asbestos workers (1971-2005). (20957726)
2010
7
Serum growth factors in asbestosis patients. (19283526)
2009
8
Antemortem diagnosis of asbestosis by screening chest radiograph correlated with postmortem histologic features of asbestosis: a study of 273 cases. (19523203)
2009
9
Pleural plaques and asbestosis: dose- and time-response relationships based on HRCT data. (19129281)
2009
10
Carboxyterminal propeptide of type I procollagen in ELF: elevation in asbestosis, but not in pleural plaque disease. (10543275)
1999
11
New technologies in diagnosing occupational asbestosis. (10376357)
1998
12
Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure. (9648950)
1998
13
An early study of pulmonary asbestosis among manufacturing workers: original data and reconstruction of the 1932 cohort. (9055956)
1997
14
Clinical predictors of mortality from asbestosis in the North American Insulator Cohort, 1981 to 1991. (9230732)
1997
15
Professor Matthew Stewart: asbestosis research 1929-1934. (9327084)
1997
16
Does asbestos or asbestosis cause carcinoma of the lung? (7892835)
1994
17
Asbestos fiber analysis in seven asbestosis cases. (8117151)
1994
18
Gamma/delta T-lymphocytes in advanced pulmonary asbestosis. (8140322)
1993
19
Computed tomography in the early detection of asbestosis. (8398855)
1993
20
Bronchoalveolar lavage and 99mTc-DTPA clearance as prognostic factors in asbestos workers with and without asbestosis. (8209056)
1993
21
Current imaging of asbestosis. (2701517)
1989
22
Roentgenographic underestimation of early asbestosis. (2707080)
1989
23
Validation of clinical criteria for diagnosing asbestosis in asbestos-cement workers. (2489415)
1989
24
Asbestosis occurring after brief inhalational exposure: usefulness of bronchoalveolar lavage in diagnosis. (2538140)
1989
25
Asbestosis among electricians. (3262731)
1988
26
Lung and blood lymphocyte subsets in asbestosis and in mixed dust pneumoconiosis. (3792062)
1987
27
The association of carcinoma, tuberculosis, asbestosis, and fibrosing alveolitis of the lung: report of a case and review of the literature. (3679907)
1987
28
Immunogenetic factors as determinants of asbestosis. (3108592)
1987
29
Correlation of bronchoalveolar lavage and clinical and functional findings in asbestosis. (3706896)
1986
30
Signs of asbestosis and impaired pulmonary function in women who worked in shipyards. (4073052)
1985
31
Diagnosis of asbestosis. Clinical, radiological and lung function data in 42 patients. (6527564)
1984
32
Asbestos related diseases without asbestosis. (6223683)
1983
33
Biochemical components of bronchoalveolar lavage in early experimental asbestosis of the sheep: phospholipase A2 activity, prostaglandin E2 and proteins. (6580167)
1983
34
Incipient cases of asbestosis in a Kenyan factory. (6671435)
1983
35
Inhalant granulomas: silicosis, asbestosis, berylliosis. (7133715)
1982
36
Inflammation and asbestosis: characterization and maintenance of alveolitis following acute asbestos exposure. (7249746)
1981
37
The development of asbestosis. (18748527)
1980
38
Asbestosis in the industries of the Barcelona area. (7342762)
1980
39
Asbestosis: a study of dose-response relationships in an asbestos textile factory. (465379)
1979
40
Computed tomography in pulmonary asbestosis. (436371)
1979
41
Elimination of asbestosis. (651728)
1978
42
Asbestosis. (73933)
1977
43
Immunological studies of patients with asbestosis. I. Studies of cell-mediated immunity. (872451)
1977
44
Diagnosis of asbestosis by transbronchial biopsy. A method to facilitate demonstration of ferruginous bodies. (848793)
1977
45
A survey of patients diagnosed as having asbestosis. (135908)
1976
46
Proceedings: HL-A type and asbestosis. (1181698)
1975
47
Asbestosis and neoplastic disorders of the hematopoietic system. (4984519)
1970
48
The radiology of asbestosis. (5798718)
1969
49
Mucociliary function in health, chronic obstructive airway disease, and asbestosis. (5781603)
1969
50
SILICO-ANTHRACOSIS PRESENTING CURIOUS BODIES SIMILAR TO THOSE IN ASBESTOSIS. (20776780)
1932

Variations for Asbestosis

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Expression for genes affiliated with Asbestosis

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Search GEO for disease gene expression data for Asbestosis.

Pathways for genes affiliated with Asbestosis

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GO Terms for genes affiliated with Asbestosis

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Cellular components related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00056157.8CAT, IL6, MUC1, SERPINA1, SOD3

Biological processes related to Asbestosis according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1glutathione derivative biosynthetic processGO:190168710.6GSTM1, GSTT1
2removal of superoxide radicalsGO:001943010.2SOD2, SOD3
3superoxide metabolic processGO:000680110.1SOD2, SOD3
4acute-phase responseGO:000695310.0IL6, SERPINA1
5negative regulation of fat cell differentiationGO:00455999.9IL6, SOD2
6response to coldGO:00094099.9IL6, SOD2
7glutathione metabolic processGO:00067499.9GSTM1, GSTT1, SOD2
8response to electrical stimulusGO:00516029.8IL6, SOD2
9response to L-ascorbic acidGO:00335919.8CAT, SOD2
10positive regulation of nitric oxide biosynthetic processGO:00454299.7IL6, SOD2
11response to hyperoxiaGO:00550939.7CAT, SOD2
12response to cadmium ionGO:00466869.4CAT, SOD2
13response to reactive oxygen speciesGO:00003029.4CAT, SOD2, SOD3
14response to activityGO:00148239.2CAT, SOD2
15response to oxidative stressGO:00069798.6CAT, OGG1, SOD2, SOD3
16oxidation-reduction processGO:00551148.5CAT, GSTT1, SOD2, SOD3
17negative regulation of apoptotic processGO:00430668.5CAT, IL6, OGG1, SOD2
18response to radiationGO:00093148.5CAT, OGG1, SOD2
19response to hypoxiaGO:00016668.4CAT, MUC1, SOD2, SOD3
20response to drugGO:00424938.2CAT, IL6, OGG1, SOD2
21agingGO:00075688.1CAT, IL6, OGG1, SOD2

Molecular functions related to Asbestosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1ATP-dependent microtubule motor activity, plus-end-directedGO:000857410.1KIF18A, KIF5A
2superoxide dismutase activityGO:00047849.8SOD2, SOD3
3glutathione transferase activityGO:00043649.8GSTM1, GSTT1
4microtubule bindingGO:00080179.3KIF18A, KIF5A, OGG1

Sources for Asbestosis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet