Ascending Cholangitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Wikipedia:⁷¹ Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

MalaCards based summary: Ascending Cholangitis is related to cholangitis and hypotropia. An important gene associated with Ascending Cholangitis is TGIF1 (TGFB Induced Factor Homeobox 1), and among its related pathways Affiliated tissues include small intestine, liver and bone, and related mouse phenotypes are cardiovascular system and endocrine/exocrine gland.

Related Diseases for Ascending Cholangitis

Sources:
²⁰GeneAnalytics, ²¹GeneCards
See all MalaCards sources

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)

id	Related Disease	Score	Top Affiliating Genes
1	cholangitis	10.5
2	hypotropia	10.4	BRD4, BSG
3	glandular tularemia	10.3	BRD4, F2
4	lateral cystocele	10.3	BRD4, F2
5	peroneal neuropathy	10.3	BRD4, F2
6	diabetic autonomic neuropathy	10.3	BRD4, F2
7	acquired thrombocytopenia	10.2	C3, MPO
8	cervical non-keratinizing squamous cell carcinoma	10.2	BRD4, CCK
9	polyarteritis nodosa	10.2	C3, MPO
10	hypoactive sexual desire disorder	10.1	BRD4, MPO
11	biliary atresia	10.1
12	hepatocellular adenoma	10.1	F2, MPO
13	anti-basement membrane glomerulonephritis	10.1	C3, MPO
14	vesicoureteral reflux	10.0	ALB, C3
15	autosomal dominant cerebellar ataxia	10.0	ALB, C3
16	van maldergem syndrome 2	10.0	C3, F2
17	hereditary antithrombin deficiency type i	10.0	ALB, F2
18	hepatitis	10.0
19	intussusception	10.0
20	marek disease	10.0	ALB, F2
21	oral cavity carcinoma in situ	10.0	ALB, F2
22	duodenal disease	9.9	ALB, F2
23	acute kidney tubular necrosis	9.9	ALB, F2
24	sphenoid sinusitis	9.9	C3, MPO
25	phototoxic dermatitis	9.9	ALB, BRD4
26	alveolar periostitis	9.9	ALB, F2
27	upper gum cancer	9.9	C3, F2, MPO
28	pneumocystosis	9.9	ALB, C3
29	placenta praevia	9.9	ALB, MPO
30	degenerative myopia	9.9	ALB, F2
31	pancreatic solid pseudopapillary carcinoma	9.9	ALB, F2
32	mental retardation, anterior maxillary protrusion, and strabismus	9.9	ALB, PKHD1, PRKD1
33	pyrimidine metabolic disorder	9.9	ALB, BRD4
34	bronchial disease	9.8	ALB, F2
35	intracranial primitive neuroectodermal tumor	9.8	ALB, MPO
36	cholelithiasis	9.8
37	pancreatitis	9.8
38	pyeloureteritis cystica	9.8	ALB, F2
39	anterior foramen magnum meningioma	9.8	ALB, F2
40	parathyroid gland disease	9.8	ALB, F2, PKHD1
41	splenic infarction	9.8	ALB, F2, PKHD1
42	dermatitis	9.8	ALB, F2, PKHD1
43	bubonic plague	9.7	ALB, F2, PKHD1
44	acute liver failure	9.7	ALB, F2
45	fibrous histiocytoma	9.7	ALB, F2
46	thrombocytopenia	9.7
47	choledocholithiasis	9.7
48	obstructive jaundice	9.7
49	afferent loop syndrome	9.7
50	autoimmune disease of cardiovascular system	9.7	ALB, F2

Graphical network of the top 20 diseases related to Ascending Cholangitis:

Symptoms & Phenotypes for Ascending Cholangitis

Sources:
⁴¹MGI
See all MalaCards sources

MGI Mouse Phenotypes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

⁴¹

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	8.8	C3, CHRM3, F2, MPO, PKHD1, PRKD1
2	endocrine/exocrine gland	MP:0005379	8.1	ALB, BSG, C3, CCK, CHRM3, PKHD1
3	nervous system	MP:0003631	7.8	C3, CCK, CHRM3, F2, HPCA, NAT1
4	homeostasis/metabolism	MP:0005376	7.5	ALB, C3, CCK, CHRM3, F2, HPCA

Drugs & Therapeutics for Ascending Cholangitis

Sources:
¹BitterDB, ⁴ClinicalTrials, ¹⁰DGIdb, ¹⁴DrugBank, ²⁹HMDB, ³³IUPHAR, ⁵⁰Novoseek, ⁵⁶PharmGKB
See all MalaCards sources

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

id

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Neomycin

approved, vet_approved

48

1404-04-2

8378

Synonyms:

(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside

(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol

11025-81-3

119-04-0

1393-86-8

1404-04-2

1405-10-3 (sulfate (salt))

4-18-00-07476 (Beilstein Handbook Reference)

72131_FLUKA

AB00443887

AC1L1QVH

Actilin

Actiline

Antibiotic 10676

Antibiotic produced by Streptomyces decaris. Neomycin B

Antibiotique

BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG

BDG-(1-4)NEB-(5-1)RIB-(3-1)NED

BPBio1_000326

BRN 0101621

BSPBio_000296

C01737

C23H46N6O13

C25H50N6O13

CCRIS 5462

CHEBI:7508

CID8378

Caswell No. 595

D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy

D05140

DB00452

DB00994

EINECS 204-292-2

EINECS 215-766-3

EPA Pesticide Chemical Code 006303

Endomixin

Enterfram

Fradiomycin

Fradiomycin B

Fradiomycinum

Framicetina

Framicetina [INN-Spanish]

Framycetin

Framycetin (INN)

Framycetin [INN:BAN:DCF]

Framycetine

Framycetine [INN-French]

Framycetinum

Framycetinum [INN-Latin]

Framygen

Fraquinol

HMS2089P15

HSDB 3242

LS-96091

LS-96095

MolPort-003-938-736

Myacine

Myacyne

Mycifradin

Myciguent

N1142_SIGMA

NCGC00179612-01

NEOMYCIN AND POLYMYXIN B SULFATES

NEOMYCIN B

NEOMYCIN SULFATE

NMY

Neo-Fradin

Neo-Rx

Neobiotic

Neobrettin

Neolate

Neomas

Neomcin

Neomicina

Neomicina [DCIT]

Neomin

Neomycin B Sulfate

Neomycin B sulfate

Neomycin Sulfate

Neomycin Sulphate

Neomycin solution

Neomycine

Neomycine [INN-French]

Neomycinum

Neomycinum [INN-Latin]

Nivemycin

PIMAVECORT

Prestwick3_000158

ST075177

Soframycin

Soframycin Ophthalmic

Soframycine

Tuttomycin

UNII-4BOC774388

UNII-I16QD7X297

USAF CB-19

VONAMYCIN

Vonamycin powder V

neomycin

2

Anti-Infective Agents

21402

3

Anti-Bacterial Agents

10884

4

Acidophilus

Nutraceutical

518

Interventional clinical trials:

id	Name	Status	NCT ID	Phase
1	Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy	Completed	NCT00166868
2	Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux Valve	Terminated	NCT00990366

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

Sources:
³⁶MalaCards
See all MalaCards sources

MalaCards organs/tissues related to Ascending Cholangitis:

³⁶

Small intestine, Liver, Bone

Publications for Ascending Cholangitis

Sources:
⁵⁷PubMed
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Articles related to Ascending Cholangitis:

(show all 41)

id	Title	Authors	Year
1	A unique case of ascending cholangitis. (27157828)	Bansal R.... Policar M.	2016
2	Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. (26354292)	Gornals J.B.... Bergamino M.A.	2015
3	Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). (23687602)	Mok S.R.... Judge T.A.	2012
4	Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. (22741115)	Kim J.K.... Bang S.	2011
5	Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. (21170836)	Akaraviputh T.... Tolan K.	2010
6	Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. (19126198)	Davies J.... Watson A.	2009
7	Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. (18570948)	Attasaranya S.... Lehman G.A.	2008
8	Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? (18787839)	Televantou D.... Hytiroglou P.	2008
9	Management of ascending cholangitis. (17556149)	Kinney T.P.	2007
10	New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. (16922901)	Li Z.H.... Dong J.	2006
11	Acute ascending cholangitis. (15108417)	Muir C.A.	2004
12	Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. (11685687)	Hsieh C.S.... Chuang J.H.	2001
13	Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. (10777197)	Yamada T.... Itoh M.	2000
14	Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. (10810996)	Lapointe J.M.... Milette S.	2000
15	Acute (ascending) cholangitis. (10987108)	Hanau L.H.... Steigbigel N.H.	2000
16	An impacted metallic clip at the ampulla causing ascending cholangitis. (9165332)	Venu R.P.... Caniglio B.	1997
17	Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. (9349766)	Honna T.... Mizuta K.	1997
18	Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. (7928157)	Jurim O.... Busuttil R.	1994
19	The role of endoscopic papillotomy in ascending cholangitis. (2053744)	Himal H.S.	1991
20	Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. (1895188)	Saeki M.... Shimizu K.	1991
21	Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. (2218872)	Himal H.S.... Lindsay T.	1990
22	Mucosal intussusception to avoid ascending cholangitis. (2207590)	Yeh T.J.... Wei C.F.	1990
23	Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)	Nakajo T.... Tsuchida Y.	1990
24	Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. (3388986)	Chiba T.	1988
25	The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. (3726751)	Yin T.P.... Goodacre R.L.	1986
26	The valved conduit prevents ascending cholangitis: a follow-up. (4087101)	Reynolds M.... Raffensperger J.G.	1985
27	Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. (6511476)	Yokoyama T.... Ichikawa T.	1984
28	Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. (6615221)	Donahoe P.K.... Hendren W.H.	1983
29	Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. (6752931)	Botelho R.J.	1982
30	Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. (7013517)	Zonnebelt S.... Wolberg W.	1981
31	Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. (741784)	Rickham P.P.	1978
32	Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. (741764)	DANKS D.M.... Smith A.L.	1978
33	Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. (741763)	Lilly J.R.... Hitch D.C.	1978
34	Ascending cholangitis diagnosed by percutaneous hepatic aspiration. (1107502)	Rogers C.A.... Sharp H.L.	1976
35	Ascending cholangitis: an urgent surgical problem. (4691603)	Cacioppo P.L.... Mason J.H.	1973
36	Ascending cholangitis after successful surgical repair of biliary atresia. (4200280)	Kobayashi A.... Shimizu K.	1973
37	The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. (5768332)	Williams R.	1969
38	The management of ascending cholangitis. II. Practical management and timing of operation. (5768333)	Dawson J.L.	1969
39	Ascending cholangitis. (5219417)	Furey A.T.	1966
40	Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. (20990634)	Martensson K.	1946
41	Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. (17866525)	Dubose F.G.	1931

Genes related to Ascending Cholangitis

Sources:
¹³DISEASES, ²¹GeneCards
See all MalaCards sources

Genes related to Ascending Cholangitis:

(show all 14)

- Elite gene

- Cancer Census gene in COSMIC

id	Symbol	Description	Score	Implication
1	TGIF1	TGFB Induced Factor Homeobox 1	16.23	DISEASES inferred ¹³
2	HPCA	Hippocalcin	16.19	DISEASES inferred ¹³
3	PKHD1	Polycystic Kidney And Hepatic Disease 1 (Autosomal Recessive)	15.70	DISEASES inferred ¹³
4	CHRM3	Cholinergic Receptor Muscarinic 3	15.35	DISEASES inferred ¹³
5	NAT1	N-Acetyltransferase 1	15.35	DISEASES inferred ¹³
6	PRKD1	Protein Kinase D1	14.78	DISEASES inferred ¹³
7	BSG	Basigin (Ok Blood Group)	14.25	DISEASES inferred ¹³
8	C3	Complement C3	13.89	DISEASES inferred ¹³
9	BRD4	Bromodomain Containing 4	13.85	DISEASES inferred ¹³
10	F2	Coagulation Factor II, Thrombin	13.82	DISEASES inferred ¹³
11	CCK	Cholecystokinin	13.79	DISEASES inferred ¹³
12	TNFRSF25	TNF Receptor Superfamily Member 25	13.71	DISEASES inferred ¹³
13	ALB	Albumin	13.62	DISEASES inferred ¹³
14	MPO	Myeloperoxidase	13.42	DISEASES inferred ¹³