MCID: ASC003
MIFTS: 33

Ascending Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14270
ICD10 32 K83.0
NCIt 46 C35372
SNOMED-CT 64 26918003
UMLS 69 C0311273

Summaries for Ascending Cholangitis

MalaCards based summary : Ascending Cholangitis is related to choledocholithiasis and cholangitis. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Syndecan-1-mediated signaling events. The drugs Neomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and bone, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

Related Diseases for Ascending Cholangitis

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 choledocholithiasis 29.6 ALB F2
2 cholangitis 10.6
3 polycystic kidney disease 3 10.4 PKDREJ PRKD1
4 pyelitis 10.3 CHRM3 PKDREJ
5 orbital cyst 10.3 F2 PKDREJ
6 biliary atresia 10.2
7 giant hemangioma 10.2 F2 TGFB1
8 orthostatic proteinuria 10.1 ALB C3
9 antipyrine metabolism 10.1 ALB F2
10 non-a-e hepatitis 10.1 ALB F2
11 fournier gangrene 10.1 ALB F2
12 abdominal tuberculosis 10.1 ALB F2
13 kwashiorkor 10.1 ALB F2
14 hepatic tuberculosis 10.1 ALB F2
15 diffuse scleroderma 10.1 TGFB1 TNFRSF25
16 occupational dermatitis 10.1 ALB C3
17 hepatic coma 10.1 ALB F2
18 splenic disease 10.1 ALB F2
19 paralytic ileus 10.1 ALB CCK
20 esophageal varix 10.1 ALB F2
21 intussusception 10.1
22 hepatitis 10.1
23 hypersplenism 10.0 ALB F2
24 compartment syndrome 10.0 ALB F2
25 hemorrhagic fever 10.0 ALB F2
26 hepatorenal syndrome 10.0 ALB F2
27 autosomal dominant polycystic kidney disease 10.0 ALB PKDREJ PRKD1
28 hypersensitivity vasculitis 9.9 C3 MPO
29 analbuminemia 9.9 ALB F2
30 henoch-schoenlein purpura 9.9 C3 MPO
31 cholelithiasis 9.9
32 pancreatitis 9.9
33 microvascular complications of diabetes 3 9.9 ALB TGFB1
34 rapidly progressive glomerulonephritis 9.8 MPO TGFB1
35 bile duct disease 9.8 ALB CCK F2
36 biliary tract disease 9.8 ALB CCK F2
37 pasteurellosis 9.8 ALB MPO
38 cholecystitis 9.8 ALB CCK F2
39 urinary tract obstruction 9.8 ALB PKDREJ TGFB1
40 urinary system disease 9.8 ALB PKDREJ TGFB1
41 chronic maxillary sinusitis 9.8 C3 MPO
42 hepatitis a 9.8 ALB F2 TGFB1
43 blood group, i system 9.8
44 gallbladder disease 1 9.8
45 thrombocytopenia 9.8
46 mucositis 9.8
47 obstructive jaundice 9.8
48 angiomyolipoma 9.8
49 afferent loop syndrome 9.8
50 gastroduodenitis 9.8

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis

Symptoms & Phenotypes for Ascending Cholangitis

MGI Mouse Phenotypes related to Ascending Cholangitis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ALB BSG C3 CCK CHRM3 TGFB1
2 homeostasis/metabolism MP:0005376 9.61 ALB C3 CCK CHRM3 F2 HPCA
3 muscle MP:0005369 9.1 ALB C3 CHRM3 MPO PRKD1 TGFB1

Drugs & Therapeutics for Ascending Cholangitis

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved 1404-04-2 8378
2 Anti-Bacterial Agents
3 Anti-Infective Agents
4 Acidophilus Nutraceutical

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy Completed NCT00166868 Lactobacillus casei rhamnosus (Lcr35);Neomycin

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

MalaCards organs/tissues related to Ascending Cholangitis:

38
Small Intestine, Liver, Bone

Publications for Ascending Cholangitis

Articles related to Ascending Cholangitis:

(show all 46)
# Title Authors Year
1
Mucinous cystic neoplasm of the liver with extrahepatic growth presenting with ascending cholangitis diagnosed by endoscopic ultrasound features: a case report. ( 29444709 )
2018
2
Ascending Cholangitis due to Heavy Lifting. ( 29033769 )
2017
3
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. ( 28330448 )
2017
4
Ascending cholangitis: rare presentation of a ruptured right-sided renal angiomyolipoma. ( 29026516 )
2017
5
A unique case of ascending cholangitis. ( 27157828 )
2016
6
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. ( 26354292 )
2015
7
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. ( 28839739 )
2013
8
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). ( 23687602 )
2012
9
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. ( 22741115 )
2011
10
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. ( 21170836 )
2010
11
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. ( 19126198 )
2009
12
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? ( 18787839 )
2008
13
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. ( 18570948 )
2008
14
Management of ascending cholangitis. ( 17556149 )
2007
15
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. ( 16922901 )
2006
16
Acute ascending cholangitis. ( 15108417 )
2004
17
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. ( 11685687 )
2001
18
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. ( 10777197 )
2000
19
Acute (ascending) cholangitis. ( 10987108 )
2000
20
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. ( 10810996 )
2000
21
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. ( 9349766 )
1997
22
An impacted metallic clip at the ampulla causing ascending cholangitis. ( 9165332 )
1997
23
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. ( 7928157 )
1994
24
The role of endoscopic papillotomy in ascending cholangitis. ( 2053744 )
1991
25
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. ( 1895188 )
1991
26
Mucosal intussusception to avoid ascending cholangitis. ( 2207590 )
1990
27
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. ( 2218872 )
1990
28
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. ( 2313499 )
1990
29
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. ( 3388986 )
1988
30
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. ( 3726751 )
1986
31
The valved conduit prevents ascending cholangitis: a follow-up. ( 4087101 )
1985
32
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. ( 6511476 )
1984
33
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. ( 6615221 )
1983
34
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. ( 6752931 )
1982
35
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. ( 7013517 )
1981
36
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. ( 741764 )
1978
37
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. ( 741784 )
1978
38
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. ( 741763 )
1978
39
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. ( 1107502 )
1976
40
Ascending cholangitis after successful surgical repair of biliary atresia. ( 4200280 )
1973
41
Ascending cholangitis: an urgent surgical problem. ( 4691603 )
1973
42
The management of ascending cholangitis. II. Practical management and timing of operation. ( 5768333 )
1969
43
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. ( 5768332 )
1969
44
Ascending cholangitis. ( 5219417 )
1966
45
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. ( 20990634 )
1946
46
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. ( 17866525 )
1931

Variations for Ascending Cholangitis

Expression for Ascending Cholangitis

Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for Ascending Cholangitis

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.38 BSG F2 TGFB1
2 9.85 BSG TGFB1

GO Terms for Ascending Cholangitis

Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB C3 CCK F2 MPO TGFB1
2 blood microparticle GO:0072562 8.92 ALB C3 F2 TGFB1

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.43 C3 F2 TGFB1
2 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.37 PRKD1 TGFB1
3 positive regulation of vascular endothelial growth factor production GO:0010575 9.32 C3 TGFB1
4 positive regulation of protein localization to nucleus GO:1900182 9.16 F2 TGFB1
5 positive regulation of collagen biosynthetic process GO:0032967 8.96 F2 TGFB1
6 inflammatory response GO:0006954 8.92 C3 PRKD1 TGFB1 TNFRSF25

Sources for Ascending Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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