MCID: ASC003
MIFTS: 37

Ascending Cholangitis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

About this section

Aliases & Descriptions for Ascending Cholangitis:

Name: Ascending Cholangitis 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:14270
ICD1027 K83.0
SNOMED-CT59 26918003
NCIt42 C35372
UMLS65 C0311273

Summaries for Ascending Cholangitis

About this section
Wikipedia:68 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

MalaCards based summary: Ascending Cholangitis is related to biliary atresia and hypophosphatasia, infantile. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways are Alanine and aspartate metabolism and NAD metabolism. Affiliated tissues include small intestine, liver and prostate, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Related Diseases for Ascending Cholangitis

About this section

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 125)
idRelated DiseaseScoreTop Affiliating Genes
1biliary atresia30.3ALB, ALPP, F2
2hypophosphatasia, infantile10.7ALPL, ALPP
3macrocytic anemia10.7ALPL, ALPP
4pseudomyxoma peritonei10.7ALPL, ALPP
5testicular germ cell cancer10.7ALPL, ALPP
6hemometra10.7ALPL, ALPP
7cervix uteri carcinoma in situ10.6ALPP, PKHD1
8cholangitis10.6
9intraorbital meningioma10.6ALPP, CCK
10pancreatic cystadenocarcinoma10.5ALPP, CCK
11brachial plexus lesion10.5CCK, CHRM3
12diabetic angiopathy10.5ALPL, ALPP
13geotrichosis10.5ALPL, ALPP, CCK
14inflammatory leiomyosarcoma10.5ALPL, ALPP
15urethral villous adenoma10.4GOT1, GOT2
16retinal dystrophies primarily involving bruch's membrane10.4GOT1, GOT2
17descending colon cancer10.4GOT1, GOT2
18typhoidal tularemia10.4GOT1, GOT2
19papillary adenoma10.4ALPL, ALPP
20mesocestoidiasis10.4GOT1, GOT2
21colon carcinoma in situ10.4GOT1, GOT2
22kluver-bucy syndrome10.3GOT1, GOT2
23pericholangitis10.3ALB, ALPL, ALPP
24skeletal muscle cancer10.3ALB, ALPL, ALPP
25prolapse of female genital organ10.3GOT1, GOT2
26rickettsia parkeri spotted fever10.2GOT1, GOT2
27inclusion body myositis10.2GOT1, GOT2
28babesiosis10.2GOT1, GOT2
29prostate adenocarcinoma10.2GOT1, GOT2
30scarlet fever10.2C3, F2
31hepatitis10.1
32intussusception10.1
33neurofibroma10.1ALB, C3
34anaerobic meningitis10.1ALPL, ALPP, ALPPL2
35breast adenocarcinoma10.1ALPL, ALPP, ALPPL2
36cervical adenitis10.1ALPL, ALPP, ALPPL2
37internal auditory canal meningioma10.1ALPL, ALPP, ALPPL2
38malignant histiocytosis10.1ALPL, ALPP, ALPPL2
39achondrogenesis10.1ALPL, ALPP, ALPPL2
40postgastrectomy syndrome10.1ALPL, ALPP, ALPPL2
41arteritic anterior ischemic optic neuropathy10.1ALPL, ALPP, ALPPL2
42fibrogenesis imperfecta ossium10.1ALPL, ALPP, ALPPL2
43mixed cell type adenoma of parathyroid10.1ALPL, ALPP, ALPPL2
44fowler's syndrome10.1ALB, F2
45xanthogranulomatous cholecystitis10.1ALPL, ALPP, ALPPL2
46axial osteomalacia10.1ALPL, ALPP, ALPPL2
47brawny scleritis10.1ALPL, ALPP, ALPPL2
48ovary rhabdomyosarcoma10.1ALPL, ALPP, ALPPL2
49pancreatic ductal carcinoma10.1ALPL, ALPP, ALPPL2
50larynx carcinoma in situ10.1ALPL, ALPP, ALPPL2

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to ascending cholangitis

Symptoms for Ascending Cholangitis

About this section

Drugs & Therapeutics for Ascending Cholangitis

About this section

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Neomycinapproved421404-04-28378
Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
11025-81-3
119-04-0
1393-86-8
1404-04-2
1405-10-3 (sulfate (salt))
4-18-00-07476 (Beilstein Handbook Reference)
72131_FLUKA
AB00443887
AC1L1QVH
Actilin
Actiline
Antibiotic 10676
Antibiotic produced by Streptomyces decaris. Neomycin B
Antibiotique
BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG
BDG-(1-4)NEB-(5-1)RIB-(3-1)NED
BPBio1_000326
BRN 0101621
BSPBio_000296
C01737
C23H46N6O13
C25H50N6O13
CCRIS 5462
CHEBI:7508
CID8378
Caswell No. 595
D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
D05140
DB00452
DB00994
EINECS 204-292-2
EINECS 215-766-3
EPA Pesticide Chemical Code 006303
Endomixin
Enterfram
Fradiomycin
Fradiomycin B
Fradiomycinum
Framicetina
Framicetina [INN-Spanish]
Framycetin
Framycetin (INN)
Framycetin [INN:BAN:DCF]
Framycetine
Framycetine [INN-French]
Framycetinum
Framycetinum [INN-Latin]
Framygen
 
Fraquinol
HMS2089P15
HSDB 3242
LS-96091
LS-96095
MolPort-003-938-736
Myacine
Myacyne
Mycifradin
Myciguent
N1142_SIGMA
NCGC00179612-01
NEOMYCIN AND POLYMYXIN B SULFATES
NEOMYCIN B
NEOMYCIN SULFATE
NMY
Neo-Fradin
Neo-Rx
Neo-fradin
Neobiotic
Neobrettin
Neolate
Neomas
Neomcin
Neomicina
Neomicina [DCIT]
Neomin
Neomycin B Sulfate
Neomycin B sulfate
Neomycin Sulfate
Neomycin Sulphate
Neomycin solution
Neomycine
Neomycine [INN-French]
Neomycinum
Neomycinum [INN-Latin]
Nivemycin
PIMAVECORT
Prestwick3_000158
ST075177
Soframycin
Soframycin Ophthalmic
Soframycine
Theraplusplus Plus
Tuttomycin
UNII-4BOC774388
UNII-I16QD7X297
USAF CB-19
VONAMYCIN
Vonamycin powder V
neomycin
2Anti-Infective Agents17220
3Anti-Bacterial Agents9140
4AcidophilusNutraceutical482

Interventional clinical trials:

idNameStatusNCT IDPhase
1Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai PortoenterostomyCompletedNCT00166868
2Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux ValveTerminatedNCT00990366

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

About this section

Anatomical Context for Ascending Cholangitis

About this section

MalaCards organs/tissues related to Ascending Cholangitis:

33
Small intestine, Liver, Prostate, Colon, Breast, Bone, Ovary

Animal Models for Ascending Cholangitis or affiliated genes

About this section

MGI Mouse Phenotypes related to Ascending Cholangitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ALB, BSG, C3, CHRM3, LIF, PKHD1
2MP:00053857.9ALPL, C3, CHRM3, F2, LIF, PKHD1
3MP:00053817.9ALB, ALPL, C3, CHRM3, F2, LIF
4MP:00053897.5ALPL, ALPPL2, BSG, C3, F2, LIF
5MP:00053797.5ALB, ALPL, BSG, C3, CCK, CHRM3
6MP:00107685.7ALB, ALPL, ALPPL2, BSG, C3, F2

Publications for Ascending Cholangitis

About this section

Articles related to Ascending Cholangitis:

(show all 42)
idTitleAuthorsYear
1
A unique case of ascending cholangitis. (27157828)
2016
2
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. (26354292)
2015
3
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). (23687602)
2012
4
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. (22741115)
2011
5
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. (21170836)
2010
6
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. (19126198)
2009
7
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. (18570948)
2008
8
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? (18787839)
2008
9
Management of ascending cholangitis. (17556149)
2007
10
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. (16922901)
2006
11
Acute ascending cholangitis. (15108417)
2004
12
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. (11685687)
2001
13
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. (10777197)
2000
14
Acute (ascending) cholangitis. (10987108)
2000
15
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. (10810996)
2000
16
An impacted metallic clip at the ampulla causing ascending cholangitis. (9165332)
1997
17
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. (9349766)
1997
18
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. (7928157)
1994
19
The role of endoscopic papillotomy in ascending cholangitis. (2053744)
1991
20
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. (1895188)
1991
21
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
22
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. (2218872)
1990
23
Mucosal intussusception to avoid ascending cholangitis. (2207590)
1990
24
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. (3388986)
1988
25
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. (3726751)
1986
26
The valved conduit prevents ascending cholangitis: a follow-up. (4087101)
1985
27
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. (6511476)
1984
28
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. (6615221)
1983
29
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. (6752931)
1982
30
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. (7013517)
1981
31
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. (741784)
1978
32
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. (741764)
1978
33
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. (741763)
1978
34
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. (1107502)
1976
35
Ascending cholangitis: an urgent surgical problem. (4691603)
1973
36
Ascending cholangitis after successful surgical repair of biliary atresia. (4200280)
1973
37
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. (5768332)
1969
38
The management of ascending cholangitis. II. Practical management and timing of operation. (5768333)
1969
39
Ascending cholangitis. (5219417)
1966
40
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. (20990634)
1946
41
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. (17866525)
1931
42
(64)

Variations for Ascending Cholangitis

About this section

Expression for genes affiliated with Ascending Cholangitis

About this section
Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for genes affiliated with Ascending Cholangitis

About this section

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6GOT1, GOT2
2
Show member pathways
9.2ALPL, ALPP, ALPPL2
39.2ALPL, ALPP, ALPPL2

GO Terms for genes affiliated with Ascending Cholangitis

About this section

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1dicarboxylic acid metabolic processGO:004364810.1GOT1, GOT2
2glutamate catabolic process to 2-oxoglutarateGO:001955110.1GOT1, GOT2
3aspartate biosynthetic processGO:000653210.1GOT1, GOT2
4decidualizationGO:004669710.1BSG, LIF
5oxaloacetate metabolic processGO:000610710.0GOT1, GOT2
6glutamate metabolic processGO:000653610.0GOT1, GOT2
7embryo implantationGO:00075669.8BSG, LIF
8aspartate metabolic processGO:00065319.8GOT1, GOT2
9response to mercury ionGO:00466899.6ALB, BSG
10response to glucocorticoidGO:00513849.4ALPL, C3, GOT1

Sources for Ascending Cholangitis

About this section
2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet