MCID: ASC003
MIFTS: 32

Ascending Cholangitis malady

Gastrointestinal diseases category

Aliases & Classifications for Ascending Cholangitis

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Aliases & Descriptions for Ascending Cholangitis:

Name: Ascending Cholangitis 10 12 65


Classifications:



External Ids:

Disease Ontology10 DOID:14270
SNOMED-CT59 26918003
NCIt42 C35372

Summaries for Ascending Cholangitis

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Wikipedia:68 Ascending cholangitis or acute cholangitis (or sometimes cholangitis without a modifier - from Greek... more...

MalaCards based summary: Ascending Cholangitis is related to cholangitis and biliary atresia. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways are NAD metabolism and Folate biosynthesis. Affiliated tissues include small intestine, liver and bone, and related mouse phenotypes are respiratory system and liver/biliary system.

Related Diseases for Ascending Cholangitis

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Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 103)
idRelated DiseaseScoreTop Affiliating Genes
1cholangitis10.9
2biliary atresia10.6
3hepatitis10.4
4intussusception10.4
5hypophosphatasia, infantile10.3ALPL, ALPP
6corpus luteum cyst10.3ALPL, ALPP
7dysentery10.3ALPL, ALPP
8cholelithiasis10.3
9pancreatitis10.3
10cerebellar astrocytoma10.2ALPL, ALPP
11mediastinum synovial sarcoma10.2ALPP, CCK
12malignant peritoneal solitary fibrous tumor10.2ALPL, ALPP
13anal margin squamous cell carcinoma10.2CACNA1E, CCK
14duodenal obstruction10.2CACNA1E, CCK
15impetigo10.2ALPL, ALPP
16prostate leiomyoma10.2ALPL, ALPP, CCK
17submucous uterine fibroid10.1ALPL, ALPP, ALPPL2
18gonadoblastoma10.1ALPL, ALPP, ALPPL2
19kidney fibrosarcoma10.1ALPL, ALPP, ALPPL2
20cerebellopontine angle primitive neuroectodermal10.1ALPL, ALPP, ALPPL2
21somatoform disorder10.1ALPL, ALPP, ALPPL2
22stickler syndrome10.1ALPL, ALPP, ALPPL2
23craniodiaphyseal dysplasia10.1ALPL, ALPP, ALPPL2
24malignant glandular tumor of peripheral nerve sheath10.1ALPL, ALPP, ALPPL2
25fibrosarcomatous osteosarcoma10.1ALPL, ALPP, ALPPL2
26colorectal adenocarcinoma10.1ALPL, ALPP, ALPPL2
27fallopian tube mucinous adenocarcinoma10.1ALPL, ALPP, ALPPL2
28esophageal varix10.1ALPL, ALPP, ALPPL2
29fascioliasis10.1ALPL, ALPP, ALPPL2
30tinea manuum10.1ALPL, ALPP, ALPPL2
31esophagus leiomyoma10.1ALPL, ALPP, ALPPL2
32factor viii deficiency10.1ALPL, ALPP, ALPPL2
33multiple spinal canal and spinal cord meningioma10.1ALPL, ALPP, ALPPL2
34pyeloureteritis cystica10.1ALPL, ALPP, ALPPL2
35invasive malignant thymoma10.1ALPL, ALPP, ALPPL2
36central nervous system hereditary degenerative disease10.1ALPL, ALPP, ALPPL2
37gamma-amino butyric acid metabolism disorder10.1ALPL, ALPP, ALPPL2
38diamond-blackfan anemia 410.1ALPL, ALPP, ALPPL2
39alzheimer disease-210.1ALPL, ALPP, ALPPL2
40tabes dorsalis10.1ALPL, ALPP, ALPPL2
41central nervous system germinoma10.1ALPL, ALPP, ALPPL2
42cutaneous mucoepidermoid carcinoma10.1ALPL, ALPP, ALPPL2
43leber congenital amaurosis 310.1ALPL, ALPP, ALPPL2
44liver leiomyoma10.1ALPL, ALPP, ALPPL2
45diaphragm disease10.1ALPL, ALPP, ALPPL2
46liver rhabdomyosarcoma10.1ALPL, ALPP, ALPPL2
47deep corneal vascularisation10.1ALPL, ALPP, ALPPL2
48pneumonic plague10.1ALPL, ALPP, ALPPL2
49thrombocytopenia10.1
50obstructive jaundice10.1

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to ascending cholangitis

Symptoms for Ascending Cholangitis

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Drugs & Therapeutics for Ascending Cholangitis

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Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Neomycinapproved371404-04-28378
Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
11025-81-3
119-04-0
1393-86-8
1404-04-2
1405-10-3 (sulfate (salt))
4-18-00-07476 (Beilstein Handbook Reference)
72131_FLUKA
AB00443887
AC1L1QVH
Actilin
Actiline
Antibiotic 10676
Antibiotic produced by Streptomyces decaris. Neomycin B
Antibiotique
BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG
BDG-(1-4)NEB-(5-1)RIB-(3-1)NED
BPBio1_000326
BRN 0101621
BSPBio_000296
C01737
C23H46N6O13
C25H50N6O13
CCRIS 5462
CHEBI:7508
CID8378
Caswell No. 595
D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
D05140
DB00452
DB00994
EINECS 204-292-2
EINECS 215-766-3
EPA Pesticide Chemical Code 006303
Endomixin
Enterfram
Fradiomycin
Fradiomycin B
Fradiomycinum
Framicetina
Framicetina [INN-Spanish]
Framycetin
Framycetin (INN)
Framycetin [INN:BAN:DCF]
Framycetine
Framycetine [INN-French]
Framycetinum
Framycetinum [INN-Latin]
Framygen
 
Fraquinol
HMS2089P15
HSDB 3242
LS-96091
LS-96095
MolPort-003-938-736
Myacine
Myacyne
Mycifradin
Myciguent
N1142_SIGMA
NCGC00179612-01
NEOMYCIN AND POLYMYXIN B SULFATES
NEOMYCIN B
NEOMYCIN SULFATE
NMY
Neo-Fradin
Neo-Rx
Neo-fradin
Neobiotic
Neobrettin
Neolate
Neomas
Neomcin
Neomicina
Neomicina [DCIT]
Neomin
Neomycin B Sulfate
Neomycin B sulfate
Neomycin Sulfate
Neomycin Sulphate
Neomycin solution
Neomycine
Neomycine [INN-French]
Neomycinum
Neomycinum [INN-Latin]
Nivemycin
PIMAVECORT
Prestwick3_000158
ST075177
Soframycin
Soframycin Ophthalmic
Soframycine
Theraplusplus Plus
Tuttomycin
UNII-4BOC774388
UNII-I16QD7X297
USAF CB-19
VONAMYCIN
Vonamycin powder V
neomycin
2AcidophilusNutraceutical444

Interventional clinical trials:

idNameStatusNCT IDPhase
1Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai PortoenterostomyCompletedNCT00166868
2Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux ValveTerminatedNCT00990366

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

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Anatomical Context for Ascending Cholangitis

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MalaCards organs/tissues related to Ascending Cholangitis:

33
Small intestine, Liver, Bone

Animal Models for Ascending Cholangitis or affiliated genes

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MGI Mouse Phenotypes related to Ascending Cholangitis:

38 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053888.5ALPL, BSG, CHRM3, F2, LIF, PKHD1
2MP:00053708.3ALB, BSG, C3, CHRM3, LIF, PKHD1
3MP:00053698.3ALB, ALPL, C3, CHRM3, LIF, PRKD1
4MP:00053858.0ALPL, C3, CHRM3, F2, LIF, PKHD1
5MP:00028738.0ALB, ALPP, C3, CACNA1E, F2, PKHD1
6MP:00053817.8ALB, ALPL, C3, CHRM3, F2, LIF
7MP:00053897.4ALPL, ALPP, BSG, C3, F2, LIF
8MP:00053797.3ALB, ALPL, C3, CACNA1E, CCK, CHRM3
9MP:00053787.3ALPL, ALPP, BSG, C3, CACNA1E, CHRM3
10MP:00053847.1ALB, ALPL, C3, F2, HPCA, LIF
11MP:00036317.1ALPL, C3, CACNA1E, CCK, CHRM3, F2
12MP:00107686.8ALB, ALPL, ALPP, BSG, C3, F2
13MP:00053766.4ALB, ALPL, C3, CACNA1E, CCK, CHRM3

Publications for Ascending Cholangitis

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Articles related to Ascending Cholangitis:

(show all 40)
idTitleAuthorsYear
1
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. (26354292)
2015
2
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). (23687602)
2012
3
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. (22741115)
2011
4
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. (21170836)
2010
5
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. (19126198)
2009
6
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. (18570948)
2008
7
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? (18787839)
2008
8
Management of ascending cholangitis. (17556149)
2007
9
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. (16922901)
2006
10
Acute ascending cholangitis. (15108417)
2004
11
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. (11685687)
2001
12
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. (10777197)
2000
13
Acute (ascending) cholangitis. (10987108)
2000
14
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. (10810996)
2000
15
An impacted metallic clip at the ampulla causing ascending cholangitis. (9165332)
1997
16
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. (9349766)
1997
17
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. (7928157)
1994
18
The role of endoscopic papillotomy in ascending cholangitis. (2053744)
1991
19
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. (1895188)
1991
20
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. (2313499)
1990
21
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. (2218872)
1990
22
Mucosal intussusception to avoid ascending cholangitis. (2207590)
1990
23
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. (3388986)
1988
24
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. (3726751)
1986
25
The valved conduit prevents ascending cholangitis: a follow-up. (4087101)
1985
26
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. (6511476)
1984
27
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. (6615221)
1983
28
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. (6752931)
1982
29
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. (7013517)
1981
30
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. (741784)
1978
31
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. (741764)
1978
32
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. (741763)
1978
33
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. (1107502)
1976
34
Ascending cholangitis: an urgent surgical problem. (4691603)
1973
35
Ascending cholangitis after successful surgical repair of biliary atresia. (4200280)
1973
36
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. (5768332)
1969
37
The management of ascending cholangitis. II. Practical management and timing of operation. (5768333)
1969
38
Ascending cholangitis. (5219417)
1966
39
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. (20990634)
1946
40
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. (17866525)
1931

Variations for Ascending Cholangitis

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Expression for genes affiliated with Ascending Cholangitis

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Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for genes affiliated with Ascending Cholangitis

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Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4ALPL, ALPP, ALPPL2
29.4ALPL, ALPP, ALPPL2

GO Terms for genes affiliated with Ascending Cholangitis

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Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1anchored component of membraneGO:00312259.7ALPL, ALPP, ALPPL2
2blood microparticleGO:00725629.1ALB, C3, F2
3extracellular spaceGO:00056157.6ALB, ALPL, C3, CCK, F2, LIF
4plasma membraneGO:00058866.2ALPL, ALPP, ALPPL2, BSG, C3, CACNA1E

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1decidualizationGO:00466979.8BSG, LIF
2retina development in camera-type eyeGO:00600419.4HPCA, LIF, TGIF1

Molecular functions related to Ascending Cholangitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1alkaline phosphatase activityGO:00040359.6ALPL, ALPP, ALPPL2
2phosphatase activityGO:00167919.4ALPL, ALPP, ALPPL2

Sources for Ascending Cholangitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet