MCID: ASC003
MIFTS: 30

Ascending Cholangitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

MalaCards integrated aliases for Ascending Cholangitis:

Name: Ascending Cholangitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14270
ICD10 33 K83.0
NCIt 47 C35372
SNOMED-CT 64 26918003
UMLS 69 C0311273

Summaries for Ascending Cholangitis

MalaCards based summary : Ascending Cholangitis is related to intussusception and glycogen storage disease viii. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways are Cell surface interactions at the vascular wall and Syndecan-1-mediated signaling events. The drugs Neomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and bone, and related phenotypes are endocrine/exocrine gland and homeostasis/metabolism

Wikipedia : 72 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

Related Diseases for Ascending Cholangitis

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
id Related Disease Score Top Affiliating Genes
1 intussusception 30.4 ALB CCK
2 glycogen storage disease viii 10.6 CHRM3 PKDREJ
3 epiphora due to excess lacrimation 10.5 F2 PKDREJ
4 cholangitis 10.5
5 non-hodgkin lymphoma, during pregnancy 10.4 ALB F2
6 non-congenital cyst of kidney 10.4 ALB C3
7 fragile x syndrome type 2 10.4 ALB F2
8 oral cavity carcinoma in situ 10.4 ALB F2
9 female infertility of uterine origin 10.3 ALB F2
10 pancreatic cystadenocarcinoma 10.3 ALB F2
11 duane retraction syndrome 10.3 ALB F2
12 chronic inflammatory demyelinating polyneuritis 10.3 ALB F2
13 folliculitis 10.3 ALB C3
14 angelucci's syndrome 10.3 ALB F2
15 childhood brain stem glioma 10.3 ALB F2
16 partial circumpapillary choroid dystrophy 10.2 C3 MPO
17 kohler's disease 10.2 ALB F2
18 rete ovarii adenoma 10.2 ALB F2
19 hepadnavirus infection 10.2 ALB F2
20 dislocation of ear ossicle 10.2 C3 MPO
21 myopia 10.1 ALB F2
22 biliary atresia 10.1
23 microcephaly 8, primary, autosomal recessive 10.1 ALB F2
24 placenta praevia 10.1 ALB MPO
25 rectum neuroendocrine neoplasm 10.1 F2 TGFB1
26 anhidrosis 10.0 CCK TGFB1
27 orbital cancer 10.0 ALB CCK F2
28 hemorrhoid 10.0 ALB CCK F2
29 fallopian tube leiomyosarcoma 10.0 ALB CCK F2
30 hepatitis 10.0
31 gum cancer 10.0 C3 F2 MPO
32 dyskeratosis congenita autosomal recessive 10.0 ALB F2
33 rheumatic fever 10.0 TGFB1 TNFRSF25
34 sphenoid sinusitis 10.0 C3 MPO
35 toxic myocarditis 9.9 ALB MPO
36 lacrimal system cancer 9.9 ALB F2 TNFRSF25
37 cervix uteri carcinoma in situ 9.9 ALB PKDREJ PRKD1
38 bardet-biedl syndrome 17 9.8 ALB MPO
39 pancreatitis 9.8
40 cholelithiasis 9.8
41 dermatomycosis 9.8 ALB C3 MPO
42 retinitis pigmentosa 17 9.8 ALB TGFB1
43 hepatocellular adenoma 9.8 F2 MPO
44 focal embolic glomerulonephritis 9.8 MPO TGFB1
45 arthus reaction 9.7 ALB MPO
46 choledocholithiasis 9.7
47 obstructive jaundice 9.7
48 afferent loop syndrome 9.7
49 gastroduodenitis 9.7
50 aneurysm 9.7

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis

Symptoms & Phenotypes for Ascending Cholangitis

MGI Mouse Phenotypes related to Ascending Cholangitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 ALB BSG C3 CCK CHRM3 TGFB1
2 homeostasis/metabolism MP:0005376 9.61 F2 HPCA MPO NAT1 TGFB1 ALB
3 muscle MP:0005369 9.1 ALB C3 CHRM3 MPO PRKD1 TGFB1

Drugs & Therapeutics for Ascending Cholangitis

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved 1404-04-2 8378
2 Anti-Bacterial Agents
3 Anti-Infective Agents
4 Acidophilus Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 A Study of HTD1801 in Healthy Subjects Recruiting NCT03099603 Phase 1 HTD1801
2 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy Completed NCT00166868 Lactobacillus casei rhamnosus (Lcr35);Neomycin
3 Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux Valve Terminated NCT00990366

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

MalaCards organs/tissues related to Ascending Cholangitis:

39
Small Intestine, Liver, Bone

Publications for Ascending Cholangitis

Articles related to Ascending Cholangitis:

(show all 43)
id Title Authors Year
1
Ascending Cholangitis secondary to migrated embolization coil of gastroduodenal artery pseudo-aneurysm a case report. ( 28330448 )
2017
2
A unique case of ascending cholangitis. ( 27157828 )
2016
3
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. ( 26354292 )
2015
4
Recurrent ascending cholangitis due to small intestinal bacterial overgrowth, gastrointestinal dysmotility and an afferent loop. ( 28839739 )
2013
5
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). ( 23687602 )
2012
6
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. ( 22741115 )
2011
7
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. ( 21170836 )
2010
8
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. ( 19126198 )
2009
9
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. ( 18570948 )
2008
10
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? ( 18787839 )
2008
11
Management of ascending cholangitis. ( 17556149 )
2007
12
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. ( 16922901 )
2006
13
Acute ascending cholangitis. ( 15108417 )
2004
14
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. ( 11685687 )
2001
15
Acute (ascending) cholangitis. ( 10987108 )
2000
16
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. ( 10810996 )
2000
17
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. ( 10777197 )
2000
18
An impacted metallic clip at the ampulla causing ascending cholangitis. ( 9165332 )
1997
19
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. ( 9349766 )
1997
20
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. ( 7928157 )
1994
21
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. ( 1895188 )
1991
22
The role of endoscopic papillotomy in ascending cholangitis. ( 2053744 )
1991
23
Mucosal intussusception to avoid ascending cholangitis. ( 2207590 )
1990
24
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. ( 2313499 )
1990
25
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. ( 2218872 )
1990
26
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. ( 3388986 )
1988
27
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. ( 3726751 )
1986
28
The valved conduit prevents ascending cholangitis: a follow-up. ( 4087101 )
1985
29
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. ( 6511476 )
1984
30
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. ( 6615221 )
1983
31
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. ( 6752931 )
1982
32
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. ( 7013517 )
1981
33
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. ( 741763 )
1978
34
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. ( 741764 )
1978
35
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. ( 741784 )
1978
36
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. ( 1107502 )
1976
37
Ascending cholangitis: an urgent surgical problem. ( 4691603 )
1973
38
Ascending cholangitis after successful surgical repair of biliary atresia. ( 4200280 )
1973
39
The management of ascending cholangitis. II. Practical management and timing of operation. ( 5768333 )
1969
40
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. ( 5768332 )
1969
41
Ascending cholangitis. ( 5219417 )
1966
42
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. ( 20990634 )
1946
43
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. ( 17866525 )
1931

Variations for Ascending Cholangitis

Expression for Ascending Cholangitis

Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for Ascending Cholangitis

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.38 BSG F2 TGFB1
2 9.85 BSG TGFB1

GO Terms for Ascending Cholangitis

Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 ALB C3 CCK F2 MPO TGFB1
2 blood microparticle GO:0072562 8.92 ALB C3 F2 TGFB1

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.5 C3 F2 TGFB1
2 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.4 PRKD1 TGFB1
3 positive regulation of vascular endothelial growth factor production GO:0010575 9.37 C3 TGFB1
4 positive regulation of protein localization to nucleus GO:1900182 9.26 F2 TGFB1
5 positive regulation of collagen biosynthetic process GO:0032967 9.16 F2 TGFB1
6 positive regulation of blood vessel endothelial cell migration GO:0043536 8.96 PRKD1 TGFB1
7 inflammatory response GO:0006954 8.92 C3 PRKD1 TGFB1 TNFRSF25

Sources for Ascending Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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