MCID: ASC003
MIFTS: 33

Ascending Cholangitis malady

Category: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

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Aliases & Descriptions for Ascending Cholangitis:

Name: Ascending Cholangitis 10 12 65

Classifications:



External Ids:

Disease Ontology10 DOID:14270
ICD1027 K83.0
SNOMED-CT59 26918003
NCIt42 C35372
UMLS65 C0311273

Summaries for Ascending Cholangitis

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Wikipedia:68 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

MalaCards based summary: Ascending Cholangitis is related to inclusion body myositis and hypophosphatasia, infantile. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways are Alanine and aspartate metabolism and NAD metabolism. Affiliated tissues include small intestine, endothelial and breast, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Related Diseases for Ascending Cholangitis

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Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 140)
idRelated DiseaseScoreTop Affiliating Genes
1inclusion body myositis30.3GOT1, GOT2
2hypophosphatasia, infantile10.5ALPL, ALPP
3macrocytic anemia10.5ALPL, ALPP
4pseudomyxoma peritonei10.5ALPL, ALPP
5testicular germ cell cancer10.5ALPL, ALPP
6hemometra10.5ALPL, ALPP
7cervix uteri carcinoma in situ10.4ALPP, PKHD1
8intraorbital meningioma10.4ALPP, CCK
9pancreatic cystadenocarcinoma10.3ALPP, CCK
10brachial plexus lesion10.3CCK, CHRM3
11diabetic angiopathy10.3ALPL, ALPP
12geotrichosis10.3ALPL, ALPP, CCK
13inflammatory leiomyosarcoma10.3ALPL, ALPP
14urethral villous adenoma10.3GOT1, GOT2
15retinal dystrophies primarily involving bruch's membrane10.3GOT1, GOT2
16descending colon cancer10.3GOT1, GOT2
17typhoidal tularemia10.3GOT1, GOT2
18papillary adenoma10.2ALPL, ALPP
19mesocestoidiasis10.2GOT1, GOT2
20colon carcinoma in situ10.2GOT1, GOT2
21colorectal cancer10.2
22tuberculosis10.2
23kluver-bucy syndrome10.2GOT1, GOT2
24pericholangitis10.2ALB, ALPL, ALPP
25skeletal muscle cancer10.2ALB, ALPL, ALPP
26prolapse of female genital organ10.2GOT1, GOT2
27rickettsia parkeri spotted fever10.1GOT1, GOT2
28babesiosis10.1GOT1, GOT2
29prostate adenocarcinoma10.1GOT1, GOT2
30scarlet fever10.1C3, F2
31neurofibroma10.1ALB, C3
32anaerobic meningitis10.1ALPL, ALPP, ALPPL2
33breast adenocarcinoma10.1ALPL, ALPP, ALPPL2
34cervical adenitis10.1ALPL, ALPP, ALPPL2
35internal auditory canal meningioma10.1ALPL, ALPP, ALPPL2
36malignant histiocytosis10.1ALPL, ALPP, ALPPL2
37myocardial infarction10.1
38prostate cancer10.1
39breast cancer10.1
40obesity10.1
41acute myocardial infarction10.1
42hepatitis10.1
43leukemia10.1
44temporal lobe epilepsy10.1
45thalassemia10.1
46ductal carcinoma in situ10.1
47hypoparathyroidism10.1
48recurrent corneal erosion10.1
49prostatitis10.1
50melanoma10.1

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to ascending cholangitis

Symptoms for Ascending Cholangitis

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Drugs & Therapeutics for Ascending Cholangitis

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Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Neomycinapproved421404-04-28378
Synonyms:
(1R,2R,3S,4R,6S)-4,6-diamino-2-{[3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranosyl]oxy}-3-hydroxycyclohexyl 2,6-diamino-2,6-dideoxy-alpha-D-glucopyranoside
(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxyoxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxycyclohexyl]oxyoxane-3,4-diol
11025-81-3
119-04-0
1393-86-8
1404-04-2
1405-10-3 (sulfate (salt))
4-18-00-07476 (Beilstein Handbook Reference)
72131_FLUKA
AB00443887
AC1L1QVH
Actilin
Actiline
Antibiotic 10676
Antibiotic produced by Streptomyces decaris. Neomycin B
Antibiotique
BDG-(1-4)CYY-(5-1)RIB-(3-1)IDG
BDG-(1-4)NEB-(5-1)RIB-(3-1)NED
BPBio1_000326
BRN 0101621
BSPBio_000296
C01737
C23H46N6O13
C25H50N6O13
CCRIS 5462
CHEBI:7508
CID8378
Caswell No. 595
D-Streptamine, O-2,6-diamino-2,6-dideoxy-.beta.-L-idopyranosyl-(1.->3)-O-.beta.-D-ribofuranosyl-(1->5)]-O-[2,6-diamino-2,6-dideoxy-.alpha.-D-glucopyranosyl-(1->4)]-2-deoxy
D05140
DB00452
DB00994
EINECS 204-292-2
EINECS 215-766-3
EPA Pesticide Chemical Code 006303
Endomixin
Enterfram
Fradiomycin
Fradiomycin B
Fradiomycinum
Framicetina
Framicetina [INN-Spanish]
Framycetin
Framycetin (INN)
Framycetin [INN:BAN:DCF]
Framycetine
Framycetine [INN-French]
Framycetinum
Framycetinum [INN-Latin]
Framygen
 
Fraquinol
HMS2089P15
HSDB 3242
LS-96091
LS-96095
MolPort-003-938-736
Myacine
Myacyne
Mycifradin
Myciguent
N1142_SIGMA
NCGC00179612-01
NEOMYCIN AND POLYMYXIN B SULFATES
NEOMYCIN B
NEOMYCIN SULFATE
NMY
Neo-Fradin
Neo-Rx
Neo-fradin
Neobiotic
Neobrettin
Neolate
Neomas
Neomcin
Neomicina
Neomicina [DCIT]
Neomin
Neomycin B Sulfate
Neomycin B sulfate
Neomycin Sulfate
Neomycin Sulphate
Neomycin solution
Neomycine
Neomycine [INN-French]
Neomycinum
Neomycinum [INN-Latin]
Nivemycin
PIMAVECORT
Prestwick3_000158
ST075177
Soframycin
Soframycin Ophthalmic
Soframycine
Theraplusplus Plus
Tuttomycin
UNII-4BOC774388
UNII-I16QD7X297
USAF CB-19
VONAMYCIN
Vonamycin powder V
neomycin
2Anti-Infective Agents17220
3Anti-Bacterial Agents9140
4AcidophilusNutraceutical482

Interventional clinical trials:

idNameStatusNCT IDPhase
1Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai PortoenterostomyCompletedNCT00166868
2Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux ValveTerminatedNCT00990366

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

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Anatomical Context for Ascending Cholangitis

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MalaCards organs/tissues related to Ascending Cholangitis:

33
Small intestine, Endothelial, Breast, Bone, Colon, Testes

Animal Models for Ascending Cholangitis or affiliated genes

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MGI Mouse Phenotypes related to Ascending Cholangitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.5ALB, BSG, C3, CHRM3, LIF, PKHD1
2MP:00053857.9ALPL, C3, CHRM3, F2, LIF, PKHD1
3MP:00053817.9ALB, ALPL, C3, CHRM3, F2, LIF
4MP:00053897.5ALPL, ALPPL2, BSG, C3, F2, LIF
5MP:00053797.5ALB, ALPL, BSG, C3, CCK, CHRM3
6MP:00107685.7ALB, ALPL, ALPPL2, BSG, C3, F2

Publications for Ascending Cholangitis

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Articles related to Ascending Cholangitis:

(show all 40)
idTitleAuthorsYear
1
The American College of Rheumatology Provisional Composite Response Index for Clinical Trials in Early Diffuse Cutaneous Systemic Sclerosis. (26806474)
2016
2
Telotristat etiprate for carcinoid syndrome: a single-arm, multicenter trial. (25636046)
2015
3
Change in paternity, risk of placental abruption and confounding by birth interval: a population-based prospective cohort study in Norway, 1967-2009. (25670732)
2015
4
Ovarian preservation in young patients with stage I cervical adenocarcinoma: a surveillance, epidemiology, and end results study. (25188889)
2014
5
Reduced L/B/K alkaline phosphatase gene expression in renal cell carcinoma: plausible role in tumorigenesis. (24909115)
2014
6
Interrelationships between ALOX5AP polymorphisms, serum leukotriene B4 level and risk of acute coronary syndrome. (25210744)
2014
7
Intravitreal bevacizumab for choroidal neovascularization secondary to angioid streaks: A report of two patients. (25473350)
2014
8
Dysregulation of anti-inflammatory annexin A1 expression in progressive Crohns Disease. (24130820)
2013
9
mTOR expression in colorectal adenoma-reply. (24411947)
2013
10
Postoperative convergence after recovery from general anesthesia in exotropia surgery. (20964275)
2011
11
Role of the 5-HT7 receptor in the central nervous system: from current status to future perspectives. (21424680)
2011
12
Involvement of matrix metalloproteinases on the inhibition of cells invasion and migration by emodin in human neuroblastoma SH-SY5Y cells. (19291397)
2009
13
P2Y2 receptor desensitization on single endothelial cells. (18568944)
2008
14
Catecholamine dysfunction in attention-deficit/hyperactivity disorder: an update. (18480676)
2008
15
Period-2: a tumor suppressor gene in breast cancer. (18334030)
2008
16
Understanding genetic progression of squamous cell carcinoma to spindle cell carcinoma in a mouse model of head and neck cancer. (17390032)
2007
17
Polymorphisms in 33 inflammatory genes and risk of myocardial infarction--a system genetics approach. (17634906)
2007
18
Association between serotonin 2C gene polymorphisms and attention deficit hyperactivity disorder in children with or without comorbidity of disruptive behavior disorder]. (17697626)
2007
19
Arginine methylation of the HIV-1 nucleocapsid protein results in its diminished function. (17415034)
2007
20
Microconversion between CYP21A2 and CYP21A1P promoter regions causes the nonclassical form of 21-hydroxylase deficiency. (17666484)
2007
21
Spastin mutations are frequent in sporadic spastic paraparesis and their spectrum is different from that observed in familial cases. (16055926)
2006
22
Hantavirus pulmonary syndrome in Latin America. (15353962)
2004
23
Tissue-specific regulation by estrogen of ezrin and ezrin/radixin/moesin-binding protein 50. (14665715)
2003
24
The effect of bone morphogenetic protein-2 on rat intervertebral disc cells in vitro. (12923462)
2003
25
Conserved mammalian gonadotropin-releasing hormone receptor carboxyl terminal amino acids regulate ligand binding, effector coupling and internalization. (11997175)
2002
26
Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis. (11278310)
2001
27
Medial epicondylitis and cubital tunnel syndrome in the throwing athlete. (11494840)
2001
28
Reduced cardiovascular morbidity and mortality in hypertensive diabetic patients on first-line therapy with an ACE inhibitor compared with a diuretic/beta-blocker-based treatment regimen: a subanalysis of the Captopril Prevention Project. (11723089)
2001
29
Alterations in muscarinic receptor-coupled phosphoinositide hydrolysis and AP-1 activation in Alzheimer's disease cybrid cells. (10794846)
2000
30
Epiphyseal involvement in Erdheim-Chester disease: radiographic and scintigraphic findings in a case with lytic lesions. (10984893)
2000
31
HMG CoA reductase inhibitors are related to improved systemic endothelial function in coronary artery disease. (10559508)
1999
32
The alpha v beta 6 integrin induces gelatinase B secretion in colon cancer cells. (10077158)
1999
33
Searching for inaccuracy in clinical laboratory testing using Medicare data. Evidence for prothrombin time. (8369028)
1993
34
Pool of ligand-bound platelet-derived growth factor beta-receptors remain activated and tyrosine phosphorylated after internalization. (7688373)
1993
35
Human pulmonary macrophages utilize prostaglandins and transforming growth factor beta 1 to suppress lymphocyte activation. (8482916)
1993
36
Tumor cytostasis mediated by a monoclonal IgM antibody promoting adhesion between macrophages and tumor cells. Evidence for a lectin-like behavior. (1560214)
1992
37
Overlap syndromes and mixed connective tissue disease. (2083165)
1990
38
Acute splenic sequestration in hemoglobin sickle O-Arab disease. (7382253)
1980
39
The influence of uremia upon renal hypertension. (5438011)
1970
40
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Variations for Ascending Cholangitis

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Expression for genes affiliated with Ascending Cholangitis

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Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for genes affiliated with Ascending Cholangitis

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Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.6GOT1, GOT2
2
Show member pathways
9.2ALPL, ALPP, ALPPL2
39.2ALPL, ALPP, ALPPL2

GO Terms for genes affiliated with Ascending Cholangitis

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Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1dicarboxylic acid metabolic processGO:004364810.1GOT1, GOT2
2glutamate catabolic process to 2-oxoglutarateGO:001955110.1GOT1, GOT2
3aspartate biosynthetic processGO:000653210.1GOT1, GOT2
4decidualizationGO:004669710.1BSG, LIF
5oxaloacetate metabolic processGO:000610710.0GOT1, GOT2
6glutamate metabolic processGO:000653610.0GOT1, GOT2
7embryo implantationGO:00075669.8BSG, LIF
8aspartate metabolic processGO:00065319.8GOT1, GOT2
9response to mercury ionGO:00466899.6ALB, BSG
10response to glucocorticoidGO:00513849.4ALPL, C3, GOT1

Sources for Ascending Cholangitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet