MCID: ASC003
MIFTS: 30

Ascending Cholangitis malady

Categories: Gastrointestinal diseases

Aliases & Classifications for Ascending Cholangitis

Aliases & Descriptions for Ascending Cholangitis:

Name: Ascending Cholangitis 12 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:14270
ICD10 33 K83.0
NCIt 47 C35372
SNOMED-CT 64 26918003
UMLS 69 C0311273

Summaries for Ascending Cholangitis

MalaCards based summary : Ascending Cholangitis is related to cholangitis and nondystrophic myotonia. An important gene associated with Ascending Cholangitis is HPCA (Hippocalcin), and among its related pathways/superpathways is Syndecan-1-mediated signaling events. The drugs Neomycin and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and bone, and related phenotypes are cardiovascular system and endocrine/exocrine gland

Wikipedia : 71 Ascending cholangitis, also known as acute cholangitis or simply cholangitis, is an infection of the... more...

Related Diseases for Ascending Cholangitis

Diseases related to Ascending Cholangitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
id Related Disease Score Top Affiliating Genes
1 cholangitis 10.5
2 nondystrophic myotonia 10.2 ALB F2
3 freiberg's disease 10.2 ALB F2
4 pharynx carcinoma in situ 10.2 ALB F2
5 hodgkin's lymphoma, lymphocytic depletion 10.1 C3 F2 MPO
6 biliary atresia 10.1
7 congenital nystagmus 10.1 ALB C3
8 fallopian tube leiomyosarcoma 10.1 ALB CCK F2
9 gastrointestinal adenoma 10.1 ALB CCK F2
10 heart aneurysm 10.1 ALB CCK F2
11 dermatomycosis 10.1 ALB C3 MPO
12 chronic inflammatory demyelinating polyneuritis 10.1 ALB F2 PKHD1
13 angelucci's syndrome 10.1 ALB F2 PKHD1
14 mixed hepatoblastoma 10.1 F2 TGFB1
15 capillary hemangioma 10.1 ALB F2 PKHD1
16 bacterial meningitis 10.1 ALB F2 MPO
17 interstitial keratitis 10.1 BRD4 BSG
18 hepatitis e 10.0 ALB BRD4 C3
19 psoriasis susceptibility 13 10.0 ALB PKHD1 PRKD1
20 brucella suis brucellosis 10.0 ALB MPO
21 holoprosencephaly 8 10.0 PKDREJ PRKD1
22 noninfectious dermatoses of eyelid 10.0 ALB F2 TGFB1
23 sclerosing adenosis of breast 10.0 ALB F2 TGFB1
24 intussusception 10.0
25 hepatitis 10.0
26 acute chest syndrome 9.9 ALB MPO TGFB1
27 proctitis 9.9 ALB F2 TGFB1
28 anhidrosis 9.9 CCK TGFB1
29 charcot-marie-tooth disease, type 1c 9.9 PKDREJ PKHD1 PRKD1
30 orofacial cleft 4 9.9 PKDREJ PKHD1 PRKD1
31 biliary cirrhosis, primary, 2 9.9 ALB C3 MPO TGFB1
32 heart valve disease 9.9 ALB C3 MPO TGFB1
33 gastrointestinal lymphoma 9.9 PKDREJ PKHD1 PRKD1
34 fiedler's myocarditis 9.9 ALB F2 PKHD1 TGFB1
35 t-cell large granular lymphocyte leukemia 9.9 PKDREJ PKHD1 PRKD1
36 cholelithiasis 9.8
37 pancreatitis 9.8
38 childhood malignant hemangiopericytoma 9.8 ALB CCK F2 MPO TGFB1
39 lung giant cell carcinoma 9.7 ALB C3 PKDREJ PKHD1
40 mucositis 9.7
41 choledocholithiasis 9.7
42 obstructive jaundice 9.7
43 afferent loop syndrome 9.7
44 thrombocytopenia 9.7
45 atrophic vulva 8.1 ALB BRD4 BSG C3 CCK CHRM3

Graphical network of the top 20 diseases related to Ascending Cholangitis:



Diseases related to Ascending Cholangitis

Symptoms & Phenotypes for Ascending Cholangitis

MGI Mouse Phenotypes related to Ascending Cholangitis:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.92 PKHD1 PRKD1 TGFB1 TGIF1 C3 CHRM3
2 endocrine/exocrine gland MP:0005379 9.86 ALB BSG C3 CCK CHRM3 PKHD1
3 liver/biliary system MP:0005370 9.63 ALB BSG C3 CHRM3 PKHD1 TGFB1
4 nervous system MP:0003631 9.61 C3 CCK CHRM3 F2 HPCA NAT1
5 reproductive system MP:0005389 9.23 TGFB1 TGIF1 BSG C3 F2 NAT1

Drugs & Therapeutics for Ascending Cholangitis

Drugs for Ascending Cholangitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Neomycin Approved, Vet_approved 1404-04-2 8378
2 Anti-Bacterial Agents
3 Anti-Infective Agents
4 Acidophilus Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 A Study of HTD1801 in Healthy Subjects Recruiting NCT03099603 Phase 1
2 Use of Probiotics to Prevent Cholangitis in Children With Biliary Atresia After the Kasai Portoenterostomy Completed NCT00166868
3 Treatment of Biliary Obstruction Using Biliary Stent With or Without Antireflux Valve Terminated NCT00990366

Search NIH Clinical Center for Ascending Cholangitis

Genetic Tests for Ascending Cholangitis

Anatomical Context for Ascending Cholangitis

MalaCards organs/tissues related to Ascending Cholangitis:

39
Small Intestine, Liver, Bone

Publications for Ascending Cholangitis

Articles related to Ascending Cholangitis:

(show all 41)
id Title Authors Year
1
A unique case of ascending cholangitis. ( 27157828 )
2016
2
Double pigtail for preventing ascending cholangitis after endoscopic ultrasonography-guided choledochoduodenostomy with lumen-apposing metal stent. ( 26354292 )
2015
3
Does the urgency of endoscopic retrograde cholangiopancreatography (ercp)/percutaneous biliary drainage (pbd) impact mortality and disease related complications in ascending cholangitis? (deim-i study). ( 23687602 )
2012
4
Endoscopic management of afferent loop syndrome after a pylorus preserving pancreatoduodenecotomy presenting with obstructive jaundice and ascending cholangitis. ( 22741115 )
2011
5
Endoscopic treatment of acute ascending cholangitis in a patient with Roux-en-Y limb obstruction after a Whipple operation. ( 21170836 )
2010
6
Ascending cholangitis presenting with Lactococcus lactis cremoris bacteraemia: a case report. ( 19126198 )
2009
7
Choledocholithiasis, ascending cholangitis, and gallstone pancreatitis. ( 18570948 )
2008
8
Toxic hepatic injury mimicking ascending cholangitis: is Pyrus amygdaliformis to blame? ( 18787839 )
2008
9
Management of ascending cholangitis. ( 17556149 )
2007
10
New strategy to prevent ascending cholangitis in larger choledochoduodenal fistula. ( 16922901 )
2006
11
Acute ascending cholangitis. ( 15108417 )
2004
12
Ascending cholangitis provokes IL-8 and MCP-1 expression and promotes inflammatory cell infiltration in the cholestatic rat liver. ( 11685687 )
2001
13
Enterococcus hirae enteropathy with ascending cholangitis and pancreatitis in a kitten. ( 10810996 )
2000
14
Acute (ascending) cholangitis. ( 10987108 )
2000
15
Ascending cholangitis as a cause of pyogenic liver abscesses complicated by a gastric submucosal abscess and fistula. ( 10777197 )
2000
16
An impacted metallic clip at the ampulla causing ascending cholangitis. ( 9165332 )
1997
17
Further experience with the antireflux valve to prevent ascending cholangitis in biliary atresia. ( 9349766 )
1997
18
Volvulus of the Roux-en-Y hepaticojejunostomy. A rare complication manifested by recurrent ascending cholangitis. ( 7928157 )
1994
19
Effectiveness of an intussusceptive antireflux valve to prevent ascending cholangitis after hepatic portojejunostomy in biliary atresia. ( 1895188 )
1991
20
The role of endoscopic papillotomy in ascending cholangitis. ( 2053744 )
1991
21
Ascending cholangitis: surgery versus endoscopic or percutaneous drainage. ( 2218872 )
1990
22
Mucosal intussusception to avoid ascending cholangitis. ( 2207590 )
1990
23
Intussusception-type antireflux valve in the Roux-en-Y loop to prevent ascending cholangitis after hepatic portojejunostomy. ( 2313499 )
1990
24
Problems involved in re-laparotomy for congenital biliary atresia: with special reference to postoperative ascending cholangitis. ( 3388986 )
1988
25
The benefit of emergency nasobiliary drain in cholelithiasis with ascending cholangitis, coagulopathy, and thrombocytopenia. ( 3726751 )
1986
26
The valved conduit prevents ascending cholangitis: a follow-up. ( 4087101 )
1985
27
Clinical and experimental studies on ascending cholangitis after Kasai's portoenterostomy for type III congenital bile duct atresia. ( 6511476 )
1984
28
Roux-en-Y on-line intussusception to avoid ascending cholangitis in biliary atresia. ( 6615221 )
1983
29
Cholelithiasis, ascending cholangitis and septicaemia. Report of a case in an 89-year-old woman. ( 6752931 )
1982
30
Ascending cholangitis secondary to a chicken bone lodged at the ampulla of Vater. ( 7013517 )
1981
31
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures for control. ( 741763 )
1978
32
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: measures and control. Invited commentary. ( 741764 )
1978
33
Postoperative ascending cholangitis following portoenterostomy for biliary atresia: Measures and control. Invited commentary. ( 741784 )
1978
34
Ascending cholangitis diagnosed by percutaneous hepatic aspiration. ( 1107502 )
1976
35
Ascending cholangitis: an urgent surgical problem. ( 4691603 )
1973
36
Ascending cholangitis after successful surgical repair of biliary atresia. ( 4200280 )
1973
37
The management of ascending cholangitis. 1. Bacteriology and choice of antibiotic. ( 5768332 )
1969
38
The management of ascending cholangitis. II. Practical management and timing of operation. ( 5768333 )
1969
39
Ascending cholangitis. ( 5219417 )
1966
40
Grave ascending cholangitis following cholangiography carried out through the cystic duct infected with E. coli. ( 20990634 )
1946
41
Gall-Bladder Function: With Special Reference to Cholecystogastrostomy and the Absence of Ascending Cholangitis. ( 17866525 )
1931

Variations for Ascending Cholangitis

Expression for Ascending Cholangitis

Search GEO for disease gene expression data for Ascending Cholangitis.

Pathways for Ascending Cholangitis

Pathways related to Ascending Cholangitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 9.85 BSG TGFB1

GO Terms for Ascending Cholangitis

Cellular components related to Ascending Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 blood microparticle GO:0072562 8.92 ALB C3 F2 TGFB1

Biological processes related to Ascending Cholangitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.46 C3 PRKD1 TGFB1 TNFRSF25
2 positive regulation of collagen biosynthetic process GO:0032967 9.26 F2 TGFB1
3 positive regulation of protein localization to nucleus GO:1900182 8.96 F2 TGFB1
4 positive regulation of blood vessel endothelial cell migration GO:0043536 8.62 PRKD1 TGFB1

Sources for Ascending Cholangitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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