MCID: ASC009
MIFTS: 22

Ascites, Chylous malady

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Ascites, Chylous

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Sources:
30ICD10 via Orphanet, 39MESH via Orphanet, 47NIH Rare Diseases, 49Novoseek, 51OMIM, 53Orphanet, 63The Human Phenotype Ontology, 67UMLS, 68UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ascites, Chylous:

Name: Ascites, Chylous 51
Chylous Ascites 47 53 67
 
Congenital Chylous Ascites 47 67
Ascites Chylous 49

Characteristics:

HPO:

63
ascites, chylous:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM51 208300
Orphanet53 ORPHA1160
ICD10 via Orphanet30 I89.8
MESH via Orphanet39 D002915
UMLS via Orphanet68 C0008732

Summaries for Ascites, Chylous

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MalaCards based summary: Ascites, Chylous, also known as chylous ascites, is related to peritonitis and pancreatitis, and has symptoms including lymphedema, abnormality of the skin and glaucoma. An important gene associated with Ascites, Chylous is SST (Somatostatin). Affiliated tissues include skin and lymph node.

Description from OMIM:51 208300

Related Diseases for Ascites, Chylous

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Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis10.3
2pancreatitis10.3
3aneurysm10.2
4pericarditis10.1
5aortic aneurysm10.1
6abdominal aortic aneurysm10.1
7lymphoma10.1
8constrictive pericarditis10.1
9lymphangioleiomyomatosis10.0
10tuberculosis10.0
11liver cirrhosis10.0
12adenocarcinoma10.0
13lymphedema10.0
14sarcoma9.6

Graphical network of diseases related to Ascites, Chylous:



Diseases related to ascites, chylous

Symptoms for Ascites, Chylous

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Symptoms by clinical synopsis from OMIM:

208300

Clinical features from OMIM:

208300

Human phenotypes related to Ascites, Chylous:

 63 53 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lymphedema63 53 hallmark (90%) Very frequent (99-80%) HP:0001004
2 abnormality of the skin63 typical (50%) HP:0000951
3 glaucoma63 53 occasional (7.5%) Occasional (29-5%) HP:0000501
4 pancreatitis63 53 occasional (7.5%) Occasional (29-5%) HP:0001733
5 abnormality of the intestine63 53 occasional (7.5%) Occasional (29-5%) HP:0002242
6 neoplasm63 53 occasional (7.5%) Occasional (29-5%) HP:0002664
7 chylous ascites63 HP:0012281
8 subcutaneous nodule53 Frequent (79-30%)
9 ascites53 Very frequent (99-80%)

Drugs & Therapeutics for Ascites, Chylous

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Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinapprovedPhase 222938916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2
Octreotideapproved, investigationalPhase 221383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
3Gastrointestinal AgentsPhase 28109
4Antineoplastic Agents, HormonalPhase 25407

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment With Octreotide in Patients With LymphangioleiomyomatosisCompletedNCT00005906Phase 2

Search NIH Clinical Center for Ascites, Chylous

Genetic Tests for Ascites, Chylous

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Anatomical Context for Ascites, Chylous

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MalaCards organs/tissues related to Ascites, Chylous:

35
Skin, Lymph node

Animal Models for Ascites, Chylous or affiliated genes

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Publications for Ascites, Chylous

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Articles related to Ascites, Chylous:

idTitleAuthorsYear
1
A curious case of ascites. Chylous ascites caused by Kaposi's sarcoma. (12647476)
2003

Variations for Ascites, Chylous

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Expression for genes affiliated with Ascites, Chylous

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Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for genes affiliated with Ascites, Chylous

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GO Terms for genes affiliated with Ascites, Chylous

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Sources for Ascites, Chylous

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
26GTR
27HGMD
28HMDB
29ICD10
30ICD10 via Orphanet
31ICD9CM
32IUPHAR
33KEGG
36MedGen
38MeSH
39MESH via Orphanet
40MGI
43NCI
44NCIt
45NDF-RT
48NINDS
49Novoseek
51OMIM
52OMIM via Orphanet
56PubMed
57QIAGEN
62SNOMED-CT via Orphanet
66Tumor Gene Family of Databases
67UMLS
68UMLS via Orphanet