MCID: ASC009
MIFTS: 22

Ascites, Chylous malady

Categories: Rare diseases, Cardiovascular diseases, Fetal diseases

Aliases & Classifications for Ascites, Chylous

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Sources:
31ICD10 via Orphanet, 40MESH via Orphanet, 48NIH Rare Diseases, 50Novoseek, 52OMIM, 54Orphanet, 64The Human Phenotype Ontology, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Ascites, Chylous:

Name: Ascites, Chylous 52
Chylous Ascites 48 54 68
 
Congenital Chylous Ascites 48 68
Ascites Chylous 50

Characteristics:

HPO:

64
ascites, chylous:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 208300
Orphanet54 ORPHA1160
ICD10 via Orphanet31 I89.8
MESH via Orphanet40 D002915
UMLS via Orphanet69 C0008732

Summaries for Ascites, Chylous

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MalaCards based summary: Ascites, Chylous, also known as chylous ascites, is related to peritonitis and pancreatitis, and has symptoms including Array, Array and Array. An important gene associated with Ascites, Chylous is SST (Somatostatin). Affiliated tissues include lymph node.

Description from OMIM:52 208300

Related Diseases for Ascites, Chylous

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Diseases related to Ascites, Chylous via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
idRelated DiseaseScoreTop Affiliating Genes
1peritonitis10.3
2pancreatitis10.3
3aneurysm10.2
4pericarditis10.1
5aortic aneurysm10.1
6abdominal aortic aneurysm10.1
7lymphoma10.1
8constrictive pericarditis10.1
9thrombosis10.1
10lymphangioleiomyomatosis10.0
11nephrotic syndrome10.0
12tuberculosis10.0
13liver cirrhosis10.0
14lymphedema10.0
15sarcoma9.6

Graphical network of diseases related to Ascites, Chylous:



Diseases related to ascites, chylous

Symptoms & Phenotypes for Ascites, Chylous

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Symptoms by clinical synopsis from OMIM:

208300

Clinical features from OMIM:

208300

Human phenotypes related to Ascites, Chylous:

 54 64 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 glaucoma64 54 Occasional (29-5%) HP:0000501
2 lymphedema64 54 Very frequent (99-80%) HP:0001004
3 subcutaneous nodule64 54 Frequent (79-30%) HP:0001482
4 ascites64 54 Very frequent (99-80%) HP:0001541
5 pancreatitis64 54 Occasional (29-5%) HP:0001733
6 abnormality of the intestine64 54 Occasional (29-5%) HP:0002242
7 neoplasm64 54 Occasional (29-5%) HP:0002664
8 chylous ascites64 HP:0012281

Drugs & Therapeutics for Ascites, Chylous

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Drugs for Ascites, Chylous (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
SomatostatinapprovedPhase 223738916-34-6, 51110-01-153481605
Synonyms:
growth hormone-inhibiting hormone (GHIH)
 
somatotropin release-inhibiting factor (SRIF)
somatotropin release-inhibiting hormone
2
Octreotideapproved, investigationalPhase 222383150-76-9383414, 6400441
Synonyms:
(4R,7S,10S,13R,16S,19R)-10-(4-aminobutyl)-19-[[(2R)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-[(1R)-1-hydroxyethyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-Aminobutyl)-19-((2-amino-3-phenylpropanoyl)amino)-16-benzyl-7-(1-hydroxyethyl)-N-(2-hydroxy-1-(hydroxymethyl)propyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaa
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-(1,3-dihydroxybutan-2-yl)-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
10-(4-aminobutyl)-19-[(2-amino-3-phenylpropanoyl)amino]-16-benzyl-N-[(2R,3R)-1,3-dihydroxybutan-2-yl]-7-(1-hydroxyethyl)-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxamide
79517-01-4 (acetate salt)
83150-76-9
AC1L1GVU
AC1L8LCD
AC1L9M4X
C07306
C5H12O2.C4H10
CHEBI:427278
CHEBI:611465
CHEMBL1680
CID383414
CID448601
CID54374
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2-7)-disulfide
D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)propyl)-L-cysteinamide cyclic (2->7)-disulfide
D00442
DRG-0115
HMS2090C09
HS-2020
 
L-Cysteinamide, D-phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L- threonyl-N-(2-hydroxy-1-(hydroxymethyl)propyl)-, cyclic (2->7)-disulfide, (R-(R*
L000453
LS-177735
LS-187135
Longastatin
NCGC00181796-01
NCI60_025753
Octreotida
Octreotida [Spanish]
Octreotide
Octreotide (USAN/INN)
Octreotide Acetate Salt
Octreotide [USAN:INN:BAN]
Octreotide-LAR
Octreotidum
Octreotidum [Latin]
Octrotide
SAN 201-995
SM 201-995
SMS 201-995
SMS-201-995
Sandostatine
Sandoz 201-995
UNII-RWM8CCW8GP
nchembio.184-comp3
zacycloicosane-4-carboxamide acetate
3Gastrointestinal AgentsPhase 28402
4Antineoplastic Agents, HormonalPhase 25592

Interventional clinical trials:

idNameStatusNCT IDPhase
1Treatment With Octreotide in Patients With LymphangioleiomyomatosisCompletedNCT00005906Phase 2
2Chyle Leak After Pancreatic SurgeryNot yet recruitingNCT03079986

Search NIH Clinical Center for Ascites, Chylous

Genetic Tests for Ascites, Chylous

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Anatomical Context for Ascites, Chylous

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MalaCards organs/tissues related to Ascites, Chylous:

36
Lymph node

Publications for Ascites, Chylous

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Articles related to Ascites, Chylous:

idTitleAuthorsYear
1
A curious case of ascites. Chylous ascites caused by Kaposi's sarcoma. (12647476)
2003

Variations for Ascites, Chylous

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Expression for genes affiliated with Ascites, Chylous

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Search GEO for disease gene expression data for Ascites, Chylous.

Pathways for genes affiliated with Ascites, Chylous

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GO Terms for genes affiliated with Ascites, Chylous

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Sources for Ascites, Chylous

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet