MCID: ASP001
MIFTS: 48

Asperger Syndrome malady

Neuronal category

Summaries for Asperger Syndrome

Sources:
8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Asperger syndrome (as) is an autism spectrum disorder. autism spectrum disorders are developmental disorders that affect how a person behaves, interacts with others, communicates, and learns. asperger syndrome is milder than autism but shares some of its symptoms. the cause of asperger syndrome is not known. it is more common in boys than girls. signs and symptoms of asperger syndrome show up by the time children are 3 years old. a major symptom is an obsessive interest in a single subject. they want to know everything about the topic and often talk about little else. they may have an excellent vocabulary but have very formal speech patterns. other symptoms include trouble reading social cues and recognizing other people's feelings having strange movements or mannerisms problems with motor skills avoiding eye contact having rituals being sensitive to certain lights, sounds, textures, or tastes all of these make it difficult for them to make friends. treatment focuses on the three main symptoms: poor communication skills, obsessive or repetitive routines, and physical clumsiness. treatments may also include behavior therapy and medicines. nih: national institute of child health and human development

MalaCards: Asperger Syndrome, also known as asperger disorder, is related to autistic disorder and obsessive-compulsive disorder. An important gene associated with Asperger Syndrome is NLGN3 (neuroligin 3), and among its related pathways are GABA A receptor activation and GABA A receptor activation. The compounds glutamate and meperidine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and cortex, and related mouse phenotype behavior/neurological.

Disease Ontology:8 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. it differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

Genetics Home Reference:21 Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.

NIH Rare Diseases:43 Asperger syndrome is a developmental disorder and falls within the autism spectrum disorders. however, unlike children with autism, children with asperger syndrome retain their early language skills. signs and symptoms of asperger syndrome may include obsessive interest in a particular topic or object, formal or advanced speech patterns, repetitive routines, peculiarities in speech and language, socially and emotionally inappropriate behavior, difficulty interacting with peers, difficulties with non-verbal communication, and often a history of delays in motor skills such as pedaling a bike, catching a ball, or climbing. last updated: 11/11/2009

NINDS:44 Asperger syndrome (AS) is a developmental disorder.

Wikipedia:64 Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger\'s, is an autism... more...

Description from OMIM:47 300494,300497

Aliases & Classifications for Asperger Syndrome

Sources:
8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 47OMIM, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

asperger syndrome 8 43 21 44 10 45 34 61
asperger disorder 43 20 21
asperger's syndrome 21
asperger's disorder 21
asperger's disease 21
asperger disease 21


External Ids:

Disease Ontology8 DOID:0050432
MeSH35 D020817
ICD1025 F84.5

Related Diseases for Asperger Syndrome

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 57)
idRelated DiseaseScoreTop Affiliating Genes
1autistic disorder30.3NLGN4X, NLGN3, MECP2, OXT, SLC6A4
2obsessive-compulsive disorder30.3SGCE, SLC6A4, OXT
3atypical autism30.2NLGN4X, NLGN3
4attention deficit hyperactivity disorder30.2SLC6A4, MECP2
5anxiety disorder30.2SLC6A4, OXT
6borderline personality disorder29.9OXT, SLC6A4
7adult syndrome10.9
8n syndrome10.8
9young syndrome10.6
10asperger syndrome susceptibility, x-linked 210.4
11asperger syndrome susceptibility, x-linked 110.4
12autism spectrum disorder10.4
13char syndrome10.3
14faces syndrome10.3
15prosopagnosia10.2
16conduct disorder10.1
17conn's syndrome10.1
18epsilon-trimethyllysine hydroxylase deficiency10.1
19asperger syndrome susceptibility 310.1
20asperger syndrome susceptibility 410.1
21autism susceptibility 1610.1
22asperger syndrome susceptibility 110.1
23autism susceptibility 1510.1
24autism susceptibility 1710.1
25autism 1810.1
26insomnia10.1
27asperger syndrome susceptibility 210.1
28autism susceptibility, x-linked 210.1
29autism susceptibility, x-linked 110.1
30autism susceptibility, x-linked 310.1
31autism x-linked 510.1
32cystic fibrosis10.0
33temporal lobe epilepsy10.0
34common variable immunodeficiency10.0
35alexithymia10.0
36arc syndrome10.0
37astrocytoma10.0
38tic disorder10.0
39writing disorder10.0
403-m syndrome10.0
41emanuel syndrome10.0
42short syndrome10.0
43wisconsin syndrome10.0
44mast syndrome10.0
45image syndrome10.0
46cant� syndrome10.0
47hypercholesterolemia10.0
48synesthesia10.0
49mosaic trisomy 110.0
50pervasive developmental disorder10.0SLC6A4, MECP2, NLGN4X

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to asperger syndrome

Clinical Features for Asperger Syndrome

Sources:
47OMIM
See all sources

Clinical features from OMIM:

300494,300497

Drugs & Therapeutics for Asperger Syndrome

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Asperger Syndrome

Drug clinical trials:

Search ClinicalTrials for Asperger Syndrome

Search NIH Clinical Center for Asperger Syndrome

Search CenterWatch for Asperger Syndrome

Genetic Tests for Asperger Syndrome

Sources:
20GeneTests
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Genetic tests related to Asperger Syndrome:

id Genetic test Affiliating Genes
1 Asperger Disorder20

Anatomical Context for Asperger Syndrome

Sources:
33MalaCards
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MalaCards organs/tissues related to Asperger Syndrome:

33
Skin, Brain, Cortex, Prefrontal cortex, Cingulate cortex, Temporal lobe, Occipital lobe, Amygdala

Animal Models for Asperger Syndrome or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Asperger Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.3SGCE, SLC6A4, OXT, NRXN1, SHANK3, MECP2

Publications for Asperger Syndrome

Sources:
51PubMed
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Articles related to Asperger Syndrome:

(show top 50)    (show all 441)
idTitleAuthorsYear
1
Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome. (24067301)
2014
2
Asperger syndrome related suicidal behavior: two case studies. (24294002)
2013
3
Asperger syndrome and "non-verbal learning problems" in a longitudinal perspective: neuropsychological and social adaptive outcome in early adult life. (23871410)
2013
4
Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. (21824190)
2012
5
Estimation of the intelligence quotient using Wechsler Intelligence Scales in children and adolescents with Asperger syndrome. (21455795)
2012
6
Consultation with the specialist: Asperger syndrome. (22045896)
2011
7
Asperger syndrome and the supposed obligation not to bring disabled lives into the world. (20675739)
2010
8
Asperger syndrome, violent thoughts and clinically isolated syndrome. (21305864)
2010
9
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. (20952166)
2010
10
Neurological soft signs in juvenile patients with Asperger syndrome, early-onset psychosis, and healthy controls. (20977684)
2010
11
Investigation of mentalizing and visuospatial perspective taking for self and other in Asperger syndrome. (19763806)
2010
12
Asperger syndrome associated with idiopathic infantile nystagmus--a report of 2 cases. (19551561)
2009
13
The not guilty verdict: psychological reactions to a diagnosis of Asperger syndrome in adulthood. (19369388)
2009
14
Conversational behaviors in youth with high-functioning ASD and Asperger syndrome. (18607708)
2009
15
Asperger syndrome. (18563474)
2009
16
Faux pas detection and intentional action in Asperger Syndrome. A replication on a French sample. (18726150)
2009
17
Association of DISC1 with autism and Asperger syndrome. (17579608)
2008
18
School-to-work transition and Asperger Syndrome. (19029670)
2008
19
Auditory cortical change detection in adults with Asperger syndrome. (17197079)
2007
20
An event related functional magnetic resonance imaging study of facial emotion processing in Asperger syndrome. (17400195)
2007
21
An epidemiological and diagnostic study of Asperger syndrome according to four sets of diagnostic criteria. (17450055)
2007
22
The overlap between alexithymia and Asperger's syndrome. (16755385)
2006
23
Childhood inattention and hyperactivity symptoms self-reported by adults with Asperger syndrome. (16299413)
2006
24
Experiences of parenting young people with a diagnosis of Asperger syndrome: a focus group study. (16776442)
2006
25
Linguistic resources of individuals with Asperger syndrome. (15823956)
2005
26
Behavioural aspects of cerebellar function in adults with Asperger syndrome. (16321884)
2005
27
Sleep disturbances in adolescents and young adults with autism and Asperger syndrome. (15618264)
2005
28
Obsessions and compulsions in Asperger syndrome and high-functioning autism. (15928364)
2005
29
Subjective face recognition difficulties, aberrant sensibility, sleeping disturbances and aberrant eating habits in families with Asperger syndrome. (15826308)
2005
30
An 8 year follow-up of a specialist supported employment service for high-ability adults with autism or Asperger syndrome. (16287704)
2005
31
Emanuel Miller lecture: confusions and controversies about Asperger syndrome. (15056300)
2004
32
Genome-wide scan for loci of Asperger syndrome. (14966474)
2004
33
The Friendship Club: an after-school program for children with Asperger syndrome. (15596981)
2004
34
Voxel-based morphometry elucidates structural neuroanatomy of high-functioning autism and Asperger syndrome. (15540637)
2004
35
Defining the intellectual profile of Asperger Syndrome: comparison with high-functioning autism. (15264496)
2004
36
'Can I join the club?': a social integration scheme for adolescents with Asperger syndrome. (12540132)
2002
37
The effectiveness of parent management training to increase self-efficacy in parents of children with Asperger syndrome. (12212918)
2002
38
Maternal discipline of children with Asperger Syndrome and nonverbal learning disorders. (12439137)
2002
39
Speech and prosody characteristics of adolescents and adults with high-functioning autism and Asperger syndrome. (11708530)
2001
40
The stress of the university experience for students with Asperger syndrome. (12441598)
2001
41
Story-telling ability in children with autism or Asperger syndrome: a window into the imagination. (10857274)
2000
42
Ask the editor. My son is an 8-year-old with high-functioning autism/asperger syndrome. (11261478)
2000
43
Social and psychiatric functioning in adolescents with Asperger syndrome compared with conduct disorder. (11039855)
2000
44
Is asperger syndrome/high-functioning autism necessarily a disability? (11014749)
2000
45
Nosological and genetic aspects of Asperger syndrome. (9813781)
1998
46
A comparative study of Asperger syndrome with high-functioning atypical autism. (9141143)
1997
47
Are people with autism and Asperger syndrome faster than normal on the Embedded Figures Test? (9255696)
1997
48
'Asperger syndrome associated with Steinert's myotonic dystrophy'. (9183272)
1997
49
Asperger syndrome in neurologic perspective. (9120229)
1996
50
The epidemiology of Asperger syndrome. A total population study. (8294522)
1993

Genetic Variations for Asperger Syndrome

Expression for genes affiliated with Asperger Syndrome

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for genes affiliated with Asperger Syndrome

Sources:
54Reactome, 12EMD Millipore, 30KEGG
See all sources

Pathways related to Asperger Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4NRXN1, MECP2
2
Hide members
10.4NLGN3, NLGN4X, NLGN4Y
310.4NRXN1, NLGN3, NLGN4X

Compounds for genes affiliated with Asperger Syndrome

Sources:
45Novoseek, 11DrugBank
See all sources

Compounds related to Asperger Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate4510.3SLC6A4, DLGAP1, OXT, SHANK3, MECP2
2meperidine45 1111.1SLC6A4, OXT

GO Terms for genes affiliated with Asperger Syndrome

Sources:
16Gene Ontology
See all sources

Cellular components related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:04521110.5NLGN4Y, NLGN4X, DISC1, SHANK3, DLGAP1
2cell junctionGO:03005410.5DLGAP1, NRXN1, SHANK3, DISC1, NLGN3, NLGN4X
3postsynaptic densityGO:01406910.4DLGAP1, DISC1, NLGN4X, NLGN4Y
4synapseGO:04520210.4NLGN3, NLGN4X, NLGN4Y
5excitatory synapseGO:06007610.3NLGN3, NLGN4X
6integral to plasma membraneGO:00588710.3NLGN4Y, NLGN4X, NLGN3, NRXN1, SLC6A4, SLC25A11
7cell surfaceGO:00998610.1NLGN4Y, NLGN4X, NLGN3, NRXN1

Biological processes related to Asperger Syndrome according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.7NLGN4X, NLGN3, NRXN1
2vocalization behaviorGO:07162510.7NRXN1, SHANK3, NLGN4X
3positive regulation of excitatory postsynaptic membrane potentialGO:200046310.7NRXN1, SHANK3, NLGN3
4positive regulation of synapse assemblyGO:05196510.7NLGN3, MECP2, NRXN1, OXT
5guanylate kinase-associated protein clusteringGO:09711710.7NRXN1, SHANK3
6regulation of long-term synaptic potentiationGO:190027110.7SHANK3, NLGN3
7positive regulation of synaptic transmission, glutamatergicGO:05196810.7NLGN3, SHANK3, NRXN1
8positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityGO:200096910.7NLGN3, SHANK3
9synapse assemblyGO:00741610.7MECP2, NLGN3, NLGN4Y
10social behaviorGO:03517610.7SLC6A4, OXT, NRXN1, SHANK3, MECP2, NLGN3
11N-methyl-D-aspartate receptor clusteringGO:09711410.7NRXN1, SHANK3
12postsynaptic membrane assemblyGO:09710410.6NRXN1, NLGN3
13memoryGO:00761310.6SHANK3, OXT, SLC6A4
14sperm ejaculationGO:04271310.6SLC6A4, OXT
15regulation of dendritic spine morphogenesisGO:06100110.6NLGN3, SHANK3
16regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.5NRXN1, NLGN3
17neuron cell-cell adhesionGO:00715810.5NRXN1, NLGN3
18cerebellum developmentGO:02154910.4MECP2, NLGN4X
19brain morphogenesisGO:04885410.4SHANK3, SLC6A4
20regulation of respiratory gaseous exchange by neurological system processGO:00208710.3NLGN3, MECP2
21synapse organizationGO:05080810.1NLGN3, NLGN4X

Molecular functions related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NRXN1, NLGN3
2neurexin family protein bindingGO:04204310.3NLGN3, NLGN4X, NLGN4Y
3receptor activityGO:00487210.1NRXN1, NLGN3, NLGN4X, NLGN4Y

Products for genes affiliated with Asperger Syndrome

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Sources for Asperger Syndrome

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet