MCID: ASP001
MIFTS: 50

Asperger Syndrome malady

Neuronal diseases category

Summaries for Asperger Syndrome

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Asperger syndrome (as) is an autism spectrum disorder. autism spectrum disorders are developmental disorders that affect how a person behaves, interacts with others, communicates, and learns. asperger syndrome is milder than autism but shares some of its symptoms. the cause of asperger syndrome is not known. it is more common in boys than girls. signs and symptoms of asperger syndrome show up by the time children are 3 years old. a major symptom is an obsessive interest in a single subject. they want to know everything about the topic and often talk about little else. they may have an excellent vocabulary but have very formal speech patterns. other symptoms include trouble reading social cues and recognizing other people's feelings having strange movements or mannerisms problems with motor skills avoiding eye contact having rituals being sensitive to certain lights, sounds, textures, or tastes all of these make it difficult for them to make friends. treatment focuses on the three main symptoms: poor communication skills, obsessive or repetitive routines, and physical clumsiness. treatments may also include behavior therapy and medicines. nih: national institute of child health and human development

MalaCards: Asperger Syndrome, also known as asperger disorder, is related to autistic disorder and schizophrenia. An important gene associated with Asperger Syndrome is NLGN3 (neuroligin 3), and among its related pathways are GABA A receptor activation and GABA A receptor activation. The compounds glutamate and meperidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotype behavior/neurological.

Disease Ontology:8 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. it differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

Genetics Home Reference:21 Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.

NIH Rare Diseases:42 Asperger syndrome is a developmental disorder and falls within the autism spectrum disorders. however, unlike children with autism, children with asperger syndrome retain their early language skills. signs and symptoms of asperger syndrome may include obsessive interest in a particular topic or object, formal or advanced speech patterns, repetitive routines, peculiarities in speech and language, socially and emotionally inappropriate behavior, difficulty interacting with peers, difficulties with non-verbal communication, and often a history of delays in motor skills such as pedaling a bike, catching a ball, or climbing. last updated: 11/11/2009

NINDS:43 Asperger syndrome (AS) is a developmental disorder.

Wikipedia:63 Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger\'s, is an autism... more...

Description from OMIM:46 300494,300497

Aliases & Classifications for Asperger Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 20GeneTests, 46OMIM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

asperger syndrome 8 42 21 43 10 44 33 60
asperger disorder 42 20 21
asperger's syndrome 21
asperger's disorder 21
asperger's disease 21
asperger disease 21


External Ids:

Disease Ontology8 DOID:0050432
MeSH34 D020817
ICD1025 F84.5

Related Diseases for Asperger Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1autistic disorder30.3NLGN4X, NLGN3, MECP2, OXT, SLC6A4
2schizophrenia30.3DISC1, MECP2, NRXN1, DLGAP1, SLC6A4
3obsessive-compulsive disorder30.3SGCE, SLC6A4, OXT
4atypical autism30.2NLGN4X, NLGN3
5attention deficit hyperactivity disorder30.2SLC6A4, MECP2
6anxiety disorder30.2SLC6A4, OXT
7psychotic disorder29.9SLC6A4, OXT, DISC1
8borderline personality disorder29.9OXT, SLC6A4
9adult syndrome10.9
10asperger syndrome susceptibility, x-linked 210.4
11asperger syndrome susceptibility, x-linked 110.4
12autism spectrum disorder10.4
13image syndrome10.4
14learning disability10.4
15prosopagnosia10.2
16personality disorder10.2
17conduct disorder10.1
18gender identity disorder10.1
19myotonic dystrophy10.1
20epsilon-trimethyllysine hydroxylase deficiency10.1
21asperger syndrome susceptibility 310.1
22asperger syndrome susceptibility 410.1
23autism susceptibility 1610.1
24asperger syndrome susceptibility 110.1
25autism susceptibility 1510.1
26autism susceptibility 1710.1
27autism 1810.1
28asperger syndrome susceptibility 210.1
29autism susceptibility, x-linked 210.1
30autism susceptibility, x-linked 110.1
31autism susceptibility, x-linked 310.1
32autism x-linked 510.1
33pervasive developmental disorder10.0SLC6A4, MECP2, NLGN4X
34social phobia10.0OXT, SLC6A4
35intellectual disability10.0NLGN4X, MECP2, SHANK3, NRXN1
36mental retardation10.0SHANK3, MECP2, NLGN3, NLGN4X
37schizoaffective disorder10.0DISC1, SLC6A4
38bipolar disorder10.0SLC6A4, OXT, DISC1
39major depressive disorder10.0
40cystic fibrosis10.0
41conversion disorder10.0
42temporal lobe epilepsy10.0
43cerebritis10.0
44common variable immunodeficiency10.0
45alexithymia10.0
46n syndrome10.0
47astrocytoma10.0
48cerebellar astrocytoma10.0
49epilepsy syndrome10.0
50mood disorder10.0

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to asperger syndrome

Clinical Features for Asperger Syndrome

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46OMIM
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Clinical features from OMIM:

300494,300497

Drugs & Therapeutics for Asperger Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Asperger Syndrome

Drug clinical trials:

Search ClinicalTrials for Asperger Syndrome

Search NIH Clinical Center for Asperger Syndrome

Search CenterWatch for Asperger Syndrome

Genetic Tests for Asperger Syndrome

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20GeneTests
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Genetic tests related to Asperger Syndrome:

id Genetic test Affiliating Genes
1 Asperger Disorder20

Anatomical Context for Asperger Syndrome

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32MalaCards
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MalaCards organs/tissues related to Asperger Syndrome:

32
Eye, Testes, Brain, Amygdala, Cortex, Skin, Prefrontal cortex, Temporal lobe

Animal Models for Asperger Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Asperger Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.3SGCE, SLC6A4, OXT, NRXN1, SHANK3, MECP2

Publications for Asperger Syndrome

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50PubMed
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Articles related to Asperger Syndrome:

(show top 50)    (show all 420)
idTitleAuthorsYear
1
An investigation of the "jumping to conclusions" data-gathering bias and paranoid thoughts in asperger syndrome. (23933997)
2014
2
Impaired theory of mind but intact decision-making in Asperger syndrome: implications for the relationship between these cognitive domains. (22981154)
2013
3
Spontaneous attention to faces in Asperger syndrome using ecologically valid static stimuli. (22987893)
2013
4
Applying the ICF to identify requirements for students with Asperger syndrome in higher education. (23957214)
2013
5
The investigation and differential diagnosis of Asperger syndrome in adults. (24290364)
2013
6
Magnetic resonance imaging volumetric findings in children with Asperger syndrome, nonverbal learning disability, or healthy controls. (23672532)
2013
7
Attitude and risk of substance use in adolescents diagnosed with Asperger syndrome. (23962420)
2013
8
Anatomy and aging of the amygdala and hippocampus in autism spectrum disorder: an in vivo magnetic resonance imaging study of Asperger syndrome. (21948742)
2012
9
Autism Spectrum Conditions. FAQs on Autism, Asperger Syndrome and Atypical Autism answered by International Experts. (21919953)
2011
10
The effect of visual spatial attention on audiovisual speech perception in adults with Asperger syndrome. (21660467)
2011
11
Social vulnerability and bullying in children with Asperger syndrome. (21430018)
2011
12
The level and nature of autistic intelligence II: what about Asperger syndrome? (21991394)
2011
13
Can retaining Asperger syndrome in DSM V help establish neurobiological endophenotypes? (20437089)
2011
14
Asperger syndrome: can the disorder be diagnosed in the adult age? (21560081)
2011
15
Asperger syndrome in adolescent and young adult males. Interview, self- and parent assessment of social, emotional, and cognitive problems. (19880274)
2010
16
Right hemisphere dysfunction and metaphor comprehension in young adults with Asperger syndrome. (20054629)
2010
17
Phonetic and phonological errors in children with high functioning autism and Asperger syndrome. (20380251)
2010
18
Should the DSM V drop Asperger syndrome? (20151184)
2010
19
Theory of mind in adults with HFA and Asperger syndrome. (19763808)
2010
20
Social competence intervention for youth with Asperger Syndrome and high-functioning autism: an initial investigation. (20162344)
2010
21
The anatomy of extended limbic pathways in Asperger syndrome: a preliminary diffusion tensor imaging tractography study. (19446642)
2009
22
The not guilty verdict: psychological reactions to a diagnosis of Asperger syndrome in adulthood. (19369388)
2009
23
Conversational behaviors in youth with high-functioning ASD and Asperger syndrome. (18607708)
2009
24
Comparison of eating attitudes between adolescent girls with and without Asperger syndrome: daughters' and mothers' reports. (18780173)
2009
25
James Joyce and Asperger syndrome. (19949213)
2009
26
Exploring the relationship between measures of self-esteem and psychological adjustment among adolescents with Asperger syndrome. (18579646)
2008
27
Association of DISC1 with autism and Asperger syndrome. (17579608)
2008
28
Brief Report: measuring the effectiveness of teaching social thinking to children with Asperger syndrome (AS) and High Functioning Autism (HFA). (18026829)
2008
29
Defining the behavioral phenotype of Asperger syndrome. (17440802)
2008
30
Altered cerebellar feedback projections in Asperger syndrome. (18495494)
2008
31
Sleep architecture and NREM alterations in children and adolescents with Asperger syndrome. (18041490)
2007
32
The Childhood Asperger Syndrome Test (CAST): test-retest reliability. (16908483)
2006
33
An experimental investigation of the phenomenology of delusional beliefs in people with Asperger syndrome. (16287703)
2005
34
Behavioural aspects of cerebellar function in adults with Asperger syndrome. (16321884)
2005
35
Three diagnostic approaches to Asperger syndrome: implications for research. (15909408)
2005
36
Asperger Syndrome, obsessive-compulsive disorder, and major depression in a patient with 45,X/46,XY mosaicism. (15153741)
2004
37
Increased presynaptic dopamine function in Asperger syndrome. (15073509)
2004
38
Changes in cerebral blood flow in Asperger syndrome during theory of mind tasks presented by the auditory route. (14505068)
2003
39
The CAST (Childhood Asperger Syndrome Test): preliminary development of a UK screen for mainstream primary-school-age children. (11918111)
2002
40
Perceptions of school by two teenage boys with Asperger syndrome and their mothers: a qualitative study. (11708388)
2001
41
Story-telling ability in children with autism or Asperger syndrome: a window into the imagination. (10857274)
2000
42
Brief report: Comparison of sensory-motor and cognitive function between autism and Asperger syndrome in preschool children. (10832782)
2000
43
'Obsessions' in children with autism or Asperger syndrome. Content analysis in terms of core domains of cognition. (10789283)
1999
44
Creativity and imagination in autism and Asperger syndrome. (10478731)
1999
45
'Theory of mind' in the brain. Evidence from a PET scan study of Asperger syndrome. (9051780)
1996
46
Obstetric factors in Asperger syndrome: comparison with high-functioning autism. (8746742)
1995
47
Developmental prosopagnosia in Asperger syndrome: presentation and discussion of an individual case. (7926319)
1994
48
Three siblings with Asperger syndrome: A family case study. (21590528)
1993
49
Brief report: a reappraisal of clumsiness as a diagnostic feature of Asperger syndrome. (1483982)
1992
50
Autism and asperger syndrome. (1346044)
1992

Genetic Variations for Asperger Syndrome

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Expression for genes affiliated with Asperger Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for genes affiliated with Asperger Syndrome

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53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Asperger Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4NRXN1, MECP2
2
Hide members
10.4NLGN3, NLGN4X, NLGN4Y
310.4NRXN1, NLGN3, NLGN4X

Compounds for genes affiliated with Asperger Syndrome

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44Novoseek, 11DrugBank
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Compounds related to Asperger Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate4410.3SLC6A4, DLGAP1, OXT, SHANK3, MECP2
2meperidine44 1111.1SLC6A4, OXT

GO Terms for genes affiliated with Asperger Syndrome

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16Gene Ontology
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Cellular components related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:04521110.5NLGN4Y, NLGN4X, DISC1, SHANK3, DLGAP1
2cell junctionGO:03005410.5DLGAP1, NRXN1, SHANK3, DISC1, NLGN3, NLGN4X
3postsynaptic densityGO:01406910.4DLGAP1, DISC1, NLGN4X, NLGN4Y
4synapseGO:04520210.4NLGN3, NLGN4X, NLGN4Y
5excitatory synapseGO:06007610.3NLGN3, NLGN4X
6integral to plasma membraneGO:00588710.3NLGN4Y, NLGN4X, NLGN3, NRXN1, SLC6A4, SLC25A11
7cell surfaceGO:00998610.1NLGN4Y, NLGN4X, NLGN3, NRXN1

Biological processes related to Asperger Syndrome according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.7NLGN4X, NLGN3, NRXN1
2vocalization behaviorGO:07162510.7NRXN1, SHANK3, NLGN4X
3positive regulation of excitatory postsynaptic membrane potentialGO:200046310.7NRXN1, SHANK3, NLGN3
4positive regulation of synapse assemblyGO:05196510.7NLGN3, MECP2, NRXN1, OXT
5guanylate kinase-associated protein clusteringGO:09711710.7NRXN1, SHANK3
6regulation of long-term synaptic potentiationGO:190027110.7SHANK3, NLGN3
7positive regulation of synaptic transmission, glutamatergicGO:05196810.7NLGN3, SHANK3, NRXN1
8positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityGO:200096910.7NLGN3, SHANK3
9synapse assemblyGO:00741610.7MECP2, NLGN3, NLGN4Y
10social behaviorGO:03517610.7SLC6A4, OXT, NRXN1, SHANK3, MECP2, NLGN3
11N-methyl-D-aspartate receptor clusteringGO:09711410.7NRXN1, SHANK3
12postsynaptic membrane assemblyGO:09710410.6NRXN1, NLGN3
13memoryGO:00761310.6SHANK3, OXT, SLC6A4
14sperm ejaculationGO:04271310.6SLC6A4, OXT
15regulation of dendritic spine morphogenesisGO:06100110.6NLGN3, SHANK3
16regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.5NRXN1, NLGN3
17neuron cell-cell adhesionGO:00715810.5NRXN1, NLGN3
18cerebellum developmentGO:02154910.4MECP2, NLGN4X
19brain morphogenesisGO:04885410.4SHANK3, SLC6A4
20regulation of respiratory gaseous exchange by neurological system processGO:00208710.3NLGN3, MECP2
21synapse organizationGO:05080810.1NLGN3, NLGN4X

Molecular functions related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NRXN1, NLGN3
2neurexin family protein bindingGO:04204310.3NLGN3, NLGN4X, NLGN4Y
3receptor activityGO:00487210.1NRXN1, NLGN3, NLGN4X, NLGN4Y

Products for genes affiliated with Asperger Syndrome

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Sources for Asperger Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet