MCID: ASP001
MIFTS: 53

Asperger Syndrome malady

Genetic diseases, Rare diseases, Mental diseases, Fetal diseases categories
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Summaries for Asperger Syndrome

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8Disease Ontology, 21Genetics Home Reference, 43NIH Rare Diseases, 34MedlinePlus, 44NINDS, 65Wikipedia, 47OMIM, 33MalaCards
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MedlinePlus:34 Asperger syndrome (as) is an autism spectrum disorder. autism spectrum disorders are developmental disorders that affect how a person behaves, interacts with others, communicates, and learns. asperger syndrome is milder than autism but shares some of its symptoms. the cause of asperger syndrome is not known. it is more common in boys than girls. signs and symptoms of asperger syndrome show up by the time children are 3 years old. a major symptom is an obsessive interest in a single subject. they want to know everything about the topic and often talk about little else. they may have an excellent vocabulary but have very formal speech patterns. other symptoms include trouble reading social cues and recognizing other people's feelings having strange movements or mannerisms problems with motor skills avoiding eye contact having rituals being sensitive to certain lights, sounds, textures, or tastes all of these make it difficult for them to make friends. treatment focuses on the three main symptoms: poor communication skills, obsessive or repetitive routines, and physical clumsiness. treatments may also include behavior therapy and medicines. nih: national institute of child health and human development

MalaCards: Asperger Syndrome, also known as asperger disorder, is related to atypical autism and autistic disorder. An important gene associated with Asperger Syndrome is NLGN3 (neuroligin 3), and among its related pathways are Ovarian steroidogenesis and Hormone ligand-binding receptors. The compounds selective serotonin reuptake inhibitors and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotypes are hearing/vestibular/ear and normal.

Disease Ontology:8 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. it differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

Genetics Home Reference:21 Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.

NIH Rare Diseases:43 Asperger syndrome is a developmental disorder and falls within the autism spectrum disorders. however, unlike children with autism, children with asperger syndrome retain their early language skills. signs and symptoms of asperger syndrome may include obsessive interest in a particular topic or object, formal or advanced speech patterns, repetitive routines, peculiarities in speech and language, socially and emotionally inappropriate behavior, difficulty interacting with peers, difficulties with non-verbal communication, and often a history of delays in motor skills such as pedaling a bike, catching a ball, or climbing. last updated: 11/11/2009

NINDS:44 Asperger syndrome (AS) is a developmental disorder.

Wikipedia:65 Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger\'s, is an autism... more...

Description from OMIM:47 300497,300494

Aliases & Classifications for Asperger Syndrome

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8Disease Ontology, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 44NINDS, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 47OMIM, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Mental diseases


Aliases & Descriptions:

asperger syndrome 8 43 21 44 10 45 34 62
asperger disorder 43 20 21
asperger's syndrome 21
asperger's disorder 21
asperger's disease 21
asperger disease 21


External Ids:

Disease Ontology8 DOID:0050432
MeSH35 D020817
ICD1025 F84.5

Related Diseases for Asperger Syndrome

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17GeneCards, 18GeneDecks
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Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1atypical autism30.3NLGN3, NLGN4X
2autistic disorder30.3HOXA1, MECP2, NLGN3, NLGN4X, SLC6A4
3attention deficit hyperactivity disorder30.3SLC6A4, MECP2
4asperger syndrome susceptibility, x-linked 210.5
5asperger syndrome susceptibility, x-linked 110.5
6autism spectrum disorder10.4
7learning disability10.4
8obsessive-compulsive disorder10.3
9prosopagnosia10.3
10schizophrenia10.3
11conduct disorder10.2
12gender identity disorder10.2
13myotonic dystrophy10.2
14personality disorder10.2
15epsilon-trimethyllysine hydroxylase deficiency10.2
16asperger syndrome susceptibility 310.2
17asperger syndrome susceptibility 410.2
18autism susceptibility 1610.2
19asperger syndrome susceptibility 110.2
20autism susceptibility 1510.2
21autism susceptibility 1710.2
22autism 1810.2
23insomnia10.2
24asperger syndrome susceptibility 210.2
25autism susceptibility, x-linked 210.2
26autism susceptibility, x-linked 110.2
27autism susceptibility, x-linked 310.2
28autism x-linked 510.2
29eating disorder10.1SLC6A4
30fragile x syndrome10.0MECP2, SLC6A4
31intellectual disability10.0NLGN4X, MECP2
32antisocial personality disorder10.0SLC6A4, GABRA6
33pervasive developmental disorder10.0SLC6A4, NLGN4X, MECP2
34cystic fibrosis10.0
35borderline personality disorder10.0
36alexithymia10.0
37temporal lobe epilepsy10.0
38cerebritis10.0
39common variable immunodeficiency10.0
40anxiety disorder10.0
41astrocytoma10.0
42cerebellar astrocytoma10.0
43mood disorder10.0
44psychotic disorder10.0
45writing disorder10.0
46hypercholesterolemia10.0
47synesthesia10.0
48blindness10.0
49hypogonadism10.0FSHB
50alcohol dependence10.0SLC6A4, GABRA6

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to asperger syndrome

Symptoms for Asperger Syndrome

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47OMIM
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Clinical features from OMIM:

300497,300494

Drugs & Therapeutics for Asperger Syndrome

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Asperger Syndrome

Search NIH Clinical Center for Asperger Syndrome

Genetic Tests for Asperger Syndrome

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20GeneTests
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Genetic tests related to Asperger Syndrome:

id Genetic test Affiliating Genes
1 Asperger Disorder20

Anatomical Context for Asperger Syndrome

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33MalaCards
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MalaCards organs/tissues related to Asperger Syndrome:

33
Eye, Testes, Brain, Amygdala, Skin, Cortex, Temporal lobe, Prefrontal cortex

Animal Models for Asperger Syndrome or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Asperger Syndrome:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2HOXA1, MECP2, GABRA6
2MP:00028738.2MECP2, SLC6A4, NLGN3, HOXA1, GABRA6
3MP:00053797.5SLC6A4, AVPR1B, MECP2, FSHB, LHB, HOXA1
4MP:00053867.5SLC6A4, GABRA6, NLGN3, NTF4, MECP2, HOXA1
5MP:00036317.4NTF4, HOXA1, SLC6A4, GABRA6, MECP2, NLGN3
6MP:00053766.8FSHB, SLC6A4, GABRA6, MECP2, AVPR1B, HOXA1

Publications for Asperger Syndrome

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52PubMed
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Articles related to Asperger Syndrome:

(show top 50)    (show all 417)
idTitleAuthorsYear
1
Asperger syndrome related suicidal behavior: two case studies. (24294002)
2013
2
Early identification of Asperger syndrome in young children. (23123877)
2013
3
Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. (21824190)
2012
4
Narrative competence and internal state language of children with Asperger Syndrome and ADHD. (22522198)
2012
5
"We are all there silently coping." The hidden experiences of parents of adults with Asperger syndrome. (22852754)
2012
6
Integrating intention and context: assessing social cognition in adults with Asperger syndrome. (23162450)
2012
7
Mosaic partial trisomy 19p12-q13.11 due to a small supernumerary marker chromosome: a locus associated with Asperger syndrome? (21815264)
2011
8
Asperger syndrome and the supposed obligation not to bring disabled lives into the world. (20675739)
2010
9
Executive functioning in children with Asperger syndrome, ADHD-combined type, ADHD-predominately inattentive type, and controls. (20140638)
2010
10
Asperger syndrome in adolescent and young adult males. Interview, self- and parent assessment of social, emotional, and cognitive problems. (19880274)
2010
11
Comorbid psychiatric disorders associated with Asperger syndrome/high-functioning autism: a community- and clinic-based study. (20177765)
2010
12
Asperger syndrome, violent thoughts and clinically isolated syndrome. (21305864)
2010
13
A descriptive social and health profile of a community sample of adults and adolescents with Asperger syndrome. (21070680)
2010
14
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. (20952166)
2010
15
Pragmatic inferences in high-functioning adults with autism and Asperger syndrome. (19052858)
2009
16
The anatomy of extended limbic pathways in Asperger syndrome: a preliminary diffusion tensor imaging tractography study. (19446642)
2009
17
Social challenges and supports from the perspective of individuals with Asperger syndrome and other autism spectrum disabilities. (18308766)
2008
18
Exploring the relationship between measures of self-esteem and psychological adjustment among adolescents with Asperger syndrome. (18579646)
2008
19
Sleep in children with Asperger syndrome. (17340201)
2008
20
Asperger syndrome and autism: a comparative longitudinal follow-up study more than 5 years after original diagnosis. (17340200)
2008
21
Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism. (17175576)
2007
22
Answering contextually demanding questions: pragmatic errors produced by children with Asperger syndrome or high-functioning autism. (17126362)
2007
23
Autobiographical memory and social problem-solving in Asperger syndrome. (16874561)
2007
24
Brief report: social and communication abilities and disabilities in higher functioning individuals with autism and Asperger syndrome. (17160458)
2007
25
Effects of vagus nerve stimulation in a patient with temporal lobe epilepsy and Asperger syndrome: case report and review of the literature. (17300990)
2007
26
Sleep architecture and NREM alterations in children and adolescents with Asperger syndrome. (18041490)
2007
27
Sleep patterns of school-age children with Asperger syndrome or high-functioning autism. (16617404)
2006
28
Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome. (16467216)
2006
29
Monozygotic twins with Asperger syndrome: differences in behaviour reflect variations in brain structure and function. (16459007)
2006
30
Diagnosis of Asperger syndrome in a 66-year-old male presenting with depression. (16734928)
2006
31
Understanding and negotiating friendships: perspectives from an adolescent with Asperger syndrome. (17088277)
2006
32
The Strange Stories test--a replication study of children and adolescents with Asperger syndrome. (15793686)
2005
33
An experimental investigation of the phenomenology of delusional beliefs in people with Asperger syndrome. (16287703)
2005
34
Higher plasma ACTH levels in adults with Asperger syndrome. (16125520)
2005
35
Linguistic resources of individuals with Asperger syndrome. (15823956)
2005
36
Finding meaning in parenting a child with Asperger syndrome: correlates of sense making and benefit finding. (15134791)
2004
37
Outcome in high-functioning adults with autism with and without early language delays: implications for the differentiation between autism and Asperger syndrome. (12708575)
2003
38
Deficient auditory processing in children with Asperger Syndrome, as indexed by event-related potentials. (12581830)
2003
39
Outcome research in Asperger syndrome and autism. (12512398)
2003
40
Psychosocial functioning in a group of Swedish adults with Asperger syndrome or high-functioning autism. (12638767)
2003
41
Misdiagnosis of Asperger syndrome as anankastic personality disorder. (12540134)
2002
42
Asperger syndrome: a proton magnetic resonance spectroscopy study of brain. (12365875)
2002
43
Temperament and character in adults with Asperger syndrome. (12212919)
2002
44
Asperger syndrome: tests of right hemisphere functioning and interhemispheric communication. (12199132)
2002
45
Speech and prosody characteristics of adolescents and adults with high-functioning autism and Asperger syndrome. (11708530)
2001
46
The Strange Stories Test: a replication with high-functioning adults with autism or Asperger syndrome. (10587886)
1999
47
Brief report: autism and Asperger syndrome in seven-year-old children: a total population study. (10478732)
1999
48
Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism. (10587887)
1999
49
A comparative study of Asperger syndrome with high-functioning atypical autism. (9141143)
1997
50
Developmental prosopagnosia in Asperger syndrome: presentation and discussion of an individual case. (7926319)
1994

Variations for Asperger Syndrome

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Expression for genes affiliated with Asperger Syndrome

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for genes affiliated with Asperger Syndrome

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50PathCards, 30KEGG, 55Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 54R&D Systems
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Compounds for genes affiliated with Asperger Syndrome

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51PharmGKB, 45Novoseek, 24HMDB, 11DrugBank, 61Tocris Bioscience
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Compounds related to Asperger Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1selective serotonin reuptake inhibitors519.7SLC6A4, GABRA6
2venlafaxine45 51 24 1112.6SLC6A4, GABRA6
3gaba459.2MECP2, GABRA6, SLC6A4
4corticosterone45 61 2411.2AVPR1B, SLC6A4
5gnrh458.9SLC6A4, FSHB, LHB
6testosterone45 61 24 1111.9SLC6A4, MECP2, FSHB
7arginine458.5SLC6A4, NTF4, MECP2, AVPR1B

GO Terms for genes affiliated with Asperger Syndrome

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16Gene Ontology
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Cellular components related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.6NLGN3, NLGN4X
2cell junctionGO:0300549.3GABRA6, NLGN4X, NLGN3
3integral component of plasma membraneGO:0058878.2SLC6A4, GABRA6, NLGN4X, NLGN3, AVPR1B

Biological processes related to Asperger Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.1NLGN4X, NLGN3
2vocalization behaviorGO:07162510.1NLGN3, NLGN4X
3neuron cell-cell adhesionGO:00715810.1NLGN4X, NLGN3
4regulation of respiratory gaseous exchange by neurological system processGO:00208710.1NLGN3, MECP2
5adult behaviorGO:03053410.0NLGN3, NLGN4X
6positive regulation of synapse assemblyGO:05196510.0MECP2, NLGN3
7synapse organizationGO:05080810.0NLGN4X, NLGN3
8cerebellum developmentGO:0215499.9NLGN4X, MECP2
9visual learningGO:0085429.8MECP2, NLGN3
10learningGO:0076129.8NLGN4X, NLGN3
11long-term memoryGO:0076169.7NTF4, MECP2
12adult locomotory behaviorGO:0083449.6NTF4, MECP2
13synapse assemblyGO:0074169.5NLGN3, MECP2
14progesterone biosynthetic processGO:0067019.5FSHB, LHB
15social behaviorGO:0351769.4SLC6A4, NLGN4X, NLGN3, MECP2
16peptide hormone processingGO:0164869.4FSHB, LHB

Molecular functions related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:0420439.8NLGN4X, NLGN3
2cell adhesion molecule bindingGO:0508399.6NLGN4X, NLGN3
3hormone activityGO:0051799.2FSHB, LHB

Products for genes affiliated with Asperger Syndrome

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Sources for Asperger Syndrome

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet