MCID: ASP001
MIFTS: 50

Asperger Syndrome malady

Neuronal diseases category

Summaries for Asperger Syndrome

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Sources:
8Disease Ontology, 21Genetics Home Reference, 42NIH Rare Diseases, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Asperger syndrome (as) is an autism spectrum disorder. autism spectrum disorders are developmental disorders that affect how a person behaves, interacts with others, communicates, and learns. asperger syndrome is milder than autism but shares some of its symptoms. the cause of asperger syndrome is not known. it is more common in boys than girls. signs and symptoms of asperger syndrome show up by the time children are 3 years old. a major symptom is an obsessive interest in a single subject. they want to know everything about the topic and often talk about little else. they may have an excellent vocabulary but have very formal speech patterns. other symptoms include trouble reading social cues and recognizing other people's feelings having strange movements or mannerisms problems with motor skills avoiding eye contact having rituals being sensitive to certain lights, sounds, textures, or tastes all of these make it difficult for them to make friends. treatment focuses on the three main symptoms: poor communication skills, obsessive or repetitive routines, and physical clumsiness. treatments may also include behavior therapy and medicines. nih: national institute of child health and human development

MalaCards: Asperger Syndrome, also known as asperger disorder, is related to autistic disorder and schizophrenia. An important gene associated with Asperger Syndrome is NLGN3 (neuroligin 3), and among its related pathways are GABA A receptor activation and GABA A receptor activation. The compounds glutamate and meperidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related mouse phenotype behavior/neurological.

Disease Ontology:8 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. it differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

Genetics Home Reference:21 Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.

NIH Rare Diseases:42 Asperger syndrome is a developmental disorder and falls within the autism spectrum disorders. however, unlike children with autism, children with asperger syndrome retain their early language skills. signs and symptoms of asperger syndrome may include obsessive interest in a particular topic or object, formal or advanced speech patterns, repetitive routines, peculiarities in speech and language, socially and emotionally inappropriate behavior, difficulty interacting with peers, difficulties with non-verbal communication, and often a history of delays in motor skills such as pedaling a bike, catching a ball, or climbing. last updated: 11/11/2009

NINDS:43 Asperger syndrome (AS) is a developmental disorder.

Wikipedia:63 Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger\'s, is an autism... more...

Description from OMIM:46 300494,300497

Aliases & Classifications for Asperger Syndrome

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 60UMLS, 46OMIM, 34MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

asperger syndrome 8 42 21 43 10 44 33 60
asperger disorder 42 20 21
asperger's syndrome 21
asperger's disorder 21
asperger's disease 21
asperger disease 21


External Ids:

Disease Ontology8 DOID:0050432
MeSH34 D020817
ICD1025 F84.5

Related Diseases for Asperger Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 54)
idRelated DiseaseScoreTop Affiliating Genes
1autistic disorder30.3NLGN4X, NLGN3, MECP2, OXT, SLC6A4
2schizophrenia30.3DISC1, MECP2, NRXN1, DLGAP1, SLC6A4
3obsessive-compulsive disorder30.3SGCE, SLC6A4, OXT
4atypical autism30.2NLGN4X, NLGN3
5attention deficit hyperactivity disorder30.2SLC6A4, MECP2
6anxiety disorder30.2SLC6A4, OXT
7psychotic disorder29.9SLC6A4, OXT, DISC1
8borderline personality disorder29.9OXT, SLC6A4
9adult syndrome10.9
10asperger syndrome susceptibility, x-linked 210.4
11asperger syndrome susceptibility, x-linked 110.4
12autism spectrum disorder10.4
13image syndrome10.4
14learning disability10.4
15prosopagnosia10.2
16personality disorder10.2
17conduct disorder10.1
18gender identity disorder10.1
19myotonic dystrophy10.1
20epsilon-trimethyllysine hydroxylase deficiency10.1
21asperger syndrome susceptibility 310.1
22asperger syndrome susceptibility 410.1
23autism susceptibility 1610.1
24asperger syndrome susceptibility 110.1
25autism susceptibility 1510.1
26autism susceptibility 1710.1
27autism 1810.1
28asperger syndrome susceptibility 210.1
29autism susceptibility, x-linked 210.1
30autism susceptibility, x-linked 110.1
31autism susceptibility, x-linked 310.1
32autism x-linked 510.1
33pervasive developmental disorder10.0SLC6A4, MECP2, NLGN4X
34social phobia10.0OXT, SLC6A4
35intellectual disability10.0NLGN4X, MECP2, SHANK3, NRXN1
36mental retardation10.0SHANK3, MECP2, NLGN3, NLGN4X
37schizoaffective disorder10.0DISC1, SLC6A4
38bipolar disorder10.0SLC6A4, OXT, DISC1
39major depressive disorder10.0
40cystic fibrosis10.0
41conversion disorder10.0
42temporal lobe epilepsy10.0
43cerebritis10.0
44common variable immunodeficiency10.0
45alexithymia10.0
46n syndrome10.0
47astrocytoma10.0
48cerebellar astrocytoma10.0
49epilepsy syndrome10.0
50mood disorder10.0

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to asperger syndrome

Clinical Features for Asperger Syndrome

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46OMIM
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Clinical features from OMIM:

300494,300497

Drugs & Therapeutics for Asperger Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Asperger Syndrome

Drug clinical trials:

Search ClinicalTrials for Asperger Syndrome

Search NIH Clinical Center for Asperger Syndrome

Search CenterWatch for Asperger Syndrome

Genetic Tests for Asperger Syndrome

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20GeneTests
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Genetic tests related to Asperger Syndrome:

id Genetic test Affiliating Genes
1 Asperger Disorder20

Anatomical Context for Asperger Syndrome

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32MalaCards
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MalaCards organs/tissues related to Asperger Syndrome:

32
Eye, Testes, Brain, Amygdala, Skin, Cortex, Temporal lobe, Prefrontal cortex

Animal Models for Asperger Syndrome or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Asperger Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.3SGCE, SLC6A4, OXT, NRXN1, SHANK3, MECP2

Publications for Asperger Syndrome

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50PubMed
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Articles related to Asperger Syndrome:

(show top 50)    (show all 420)
idTitleAuthorsYear
1
Social anxiety in parents of high-functioning children with autism and Asperger syndrome. (22733299)
2013
2
Brief report: CANTAB performance and brain structure in pediatric patients with Asperger syndrome. (23117423)
2013
3
Abnormalities in fronto-striatal connectivity within language networks relate to differences in grey-matter heterogeneity in Asperger syndrome. (24179823)
2013
4
Transition to community by adolescents with Asperger syndrome: staying afloat in a sea change. (23769482)
2013
5
Asperger syndrome and DSM-5: a dilemma for a college freshman. (24042084)
2013
6
Fascination and isolation: a grounded theory exploration of unusual sensory experiences in adults with Asperger syndrome. (22923038)
2013
7
Exploring fathers' perceptions of parenting a child with Asperger syndrome. (23803646)
2013
8
"We are all there silently coping." The hidden experiences of parents of adults with Asperger syndrome. (22852754)
2012
9
Effects of video modeling on communicative social skills of college students with Asperger syndrome. (23030681)
2012
10
Erratum to: The effect of visual spatial attention on audiovisual speech perception in adults with Asperger syndrome. (22349502)
2012
11
Is an adult with Asperger syndrome sitting in your waiting room? (23208993)
2012
12
Functional analysis of insistence on sameness in an 11-year old boy with Asperger syndrome. (22494085)
2012
13
Mosaic partial trisomy 19p12-q13.11 due to a small supernumerary marker chromosome: a locus associated with Asperger syndrome? (21815264)
2011
14
Semantic integration during metaphor comprehension in Asperger syndrome. (20359737)
2010
15
Auditory stream segregation in children with Asperger syndrome. (19751798)
2009
16
Brief report: cognitive flexibility and focused attention in children and adolescents with Asperger syndrome or high-functioning autism as measured on the computerized version of the Wisconsin Card Sorting Test. (17965928)
2008
17
Offending behaviour in adults with Asperger syndrome. (17805955)
2008
18
Brief report: imitation of meaningless gestures in individuals with Asperger syndrome and High-Functioning Autism. (17665296)
2008
19
Answering contextually demanding questions: pragmatic errors produced by children with Asperger syndrome or high-functioning autism. (17126362)
2007
20
Autobiographical memory and social problem-solving in Asperger syndrome. (16874561)
2007
21
Quantitative assessment of neuromotor function in adolescents with high functioning autism and Asperger Syndrome. (17171541)
2007
22
Did Hans Asperger (1906-1980) have Asperger syndrome? (17917805)
2007
23
Sleep patterns of school-age children with Asperger syndrome or high-functioning autism. (16617404)
2006
24
Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome. (16467216)
2006
25
Auditory perception and attention as reflected by the brain event-related potentials in children with Asperger syndrome. (16890012)
2006
26
Social comparison processes and depressive symptoms in children and adolescents with Asperger syndrome. (16613864)
2006
27
Comment on "Asperger syndrome: Familial, pre- and perinatal factors" by Gillberg and Cederland. (16568359)
2006
28
Clinical neurological abnormalities in young adults with Asperger syndrome. (16594952)
2006
29
The mitochondrial DNA A3243A>G mutation must be an infrequent cause of Asperger syndrome. (16887455)
2006
30
Similarities in the phenotype of the auditory neural substrate in children with Asperger syndrome and their parents. (16115221)
2005
31
Repetitive behavior profiles in Asperger syndrome and high-functioning autism. (15909401)
2005
32
Can a diagnosis of Asperger syndrome be made in very young children with suspected autism spectrum disorder? (15909403)
2005
33
The Friendship Club: an after-school program for children with Asperger syndrome. (15596981)
2004
34
Spatial frequency and face processing in children with autism and Asperger syndrome. (15162938)
2004
35
Empathising and systemising in adults with and without Asperger Syndrome. (15264498)
2004
36
Asperger syndrome. (12512394)
2003
37
Asperger syndrome: to be or not to be? (14508298)
2003
38
Insomnia is a frequent finding in adults with Asperger syndrome. (14563215)
2003
39
Brief report: postural reactivity to fast visual motion differentiates autistic from children with Asperger syndrome. (12108625)
2002
40
Sensory processing issues associated with Asperger syndrome: a preliminary investigation. (11833406)
2002
41
The "Reading the Mind in the Eyes" Test revised version: a study with normal adults, and adults with Asperger syndrome or high-functioning autism. (11280420)
2001
42
Is asperger syndrome/high-functioning autism necessarily a disability? (11014749)
2000
43
'Asperger syndrome associated with Steinert's myotonic dystrophy'. (9183272)
1997
44
Parents of Children with Asperger Syndrome: What is the Cognitive Phenotype? (23968217)
1997
45
Asperger syndrome, autism and attention disorders: a comparative study of the cognitive profiles of 120 children. (9232467)
1997
46
Social communication and its disorder in autism and Asperger syndrome. (22302727)
1996
47
Brief report: thought disorder in Asperger syndrome: comparison with high-functioning autism. (7559296)
1995
48
Sampling the form of inner experience in three adults with Asperger syndrome. (8084934)
1994
49
Asperger syndrome and clumsiness. (8106310)
1993
50
Brief report: a comparison of the diagnostic criteria for Asperger syndrome. (1483981)
1992

Genetic Variations for Asperger Syndrome

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Expression for genes affiliated with Asperger Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for genes affiliated with Asperger Syndrome

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53Reactome, 12EMD Millipore, 29KEGG
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Pathways related to Asperger Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4NRXN1, MECP2
2
Hide members
10.4NLGN3, NLGN4X, NLGN4Y
310.4NRXN1, NLGN3, NLGN4X

Compounds for genes affiliated with Asperger Syndrome

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44Novoseek, 11DrugBank
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Compounds related to Asperger Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1glutamate4410.3SLC6A4, DLGAP1, OXT, SHANK3, MECP2
2meperidine44 1111.1SLC6A4, OXT

GO Terms for genes affiliated with Asperger Syndrome

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16Gene Ontology
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Cellular components related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1postsynaptic membraneGO:04521110.5NLGN4Y, NLGN4X, DISC1, SHANK3, DLGAP1
2cell junctionGO:03005410.5DLGAP1, NRXN1, SHANK3, DISC1, NLGN3, NLGN4X
3postsynaptic densityGO:01406910.4DLGAP1, DISC1, NLGN4X, NLGN4Y
4synapseGO:04520210.4NLGN3, NLGN4X, NLGN4Y
5excitatory synapseGO:06007610.3NLGN3, NLGN4X
6integral to plasma membraneGO:00588710.3NLGN4Y, NLGN4X, NLGN3, NRXN1, SLC6A4, SLC25A11
7cell surfaceGO:00998610.1NLGN4Y, NLGN4X, NLGN3, NRXN1

Biological processes related to Asperger Syndrome according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.7NLGN4X, NLGN3, NRXN1
2vocalization behaviorGO:07162510.7NRXN1, SHANK3, NLGN4X
3positive regulation of excitatory postsynaptic membrane potentialGO:200046310.7NRXN1, SHANK3, NLGN3
4positive regulation of synapse assemblyGO:05196510.7NLGN3, MECP2, NRXN1, OXT
5guanylate kinase-associated protein clusteringGO:09711710.7NRXN1, SHANK3
6regulation of long-term synaptic potentiationGO:190027110.7SHANK3, NLGN3
7positive regulation of synaptic transmission, glutamatergicGO:05196810.7NLGN3, SHANK3, NRXN1
8positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityGO:200096910.7NLGN3, SHANK3
9synapse assemblyGO:00741610.7MECP2, NLGN3, NLGN4Y
10social behaviorGO:03517610.7SLC6A4, OXT, NRXN1, SHANK3, MECP2, NLGN3
11N-methyl-D-aspartate receptor clusteringGO:09711410.7NRXN1, SHANK3
12postsynaptic membrane assemblyGO:09710410.6NRXN1, NLGN3
13memoryGO:00761310.6SHANK3, OXT, SLC6A4
14sperm ejaculationGO:04271310.6SLC6A4, OXT
15regulation of dendritic spine morphogenesisGO:06100110.6NLGN3, SHANK3
16regulation of N-methyl-D-aspartate selective glutamate receptor activityGO:200031010.5NRXN1, NLGN3
17neuron cell-cell adhesionGO:00715810.5NRXN1, NLGN3
18cerebellum developmentGO:02154910.4MECP2, NLGN4X
19brain morphogenesisGO:04885410.4SHANK3, SLC6A4
20regulation of respiratory gaseous exchange by neurological system processGO:00208710.3NLGN3, MECP2
21synapse organizationGO:05080810.1NLGN3, NLGN4X

Molecular functions related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NRXN1, NLGN3
2neurexin family protein bindingGO:04204310.3NLGN3, NLGN4X, NLGN4Y
3receptor activityGO:00487210.1NRXN1, NLGN3, NLGN4X, NLGN4Y

Products for genes affiliated with Asperger Syndrome

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Sources for Asperger Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet