Summaries for Asperger Syndrome

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6Disease Ontology, 23MedlinePlus, 31NINDS, 17Genetics Home Reference, 44Wikipedia, 22MalaCards
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MedlinePlus: Asperger's syndrome (as) is an autism spectrum disorder. it is milder than autism but shares some of its symptoms. it is more common in boys than girls. an obsessive interest in a single subject is a major symptom of as. some children with as have become experts on dinosaurs, makes and models of cars, even objects as seemingly odd as vacuum cleaners. their expertise, high level of vocabulary and formal speech patterns make them seem like little professors. children with as have trouble reading social cues and recognizing other people's feelings. they may have strange movements or mannerisms. all of these make it difficult for them to make friends. problems with motor skills are also common in children with as. they may be late learning to ride a bike or catch a ball, for example. treatment focuses on the three main symptoms: poor communication skills, obsessive or repetitive routines, and physical clumsiness. nih: national institute of neurological disorders and stroke23

MalaCards: Asperger Syndrome, also known as asperger's syndrome, is related to autistic disorder and pervasive developmental disorder. An important gene associated with Asperger Syndrome is NLGN3 (neuroligin 3), and among its related pathways is GABA signaling in brain. The compounds fluoxetine and meperidine have been mentioned in the context of this disorder. Related mouse phenotypes are nervous system and behavior/neurological.

Disease Ontology: An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. it differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.6

NINDS: Asperger syndrome (AS) is a developmental disorder.31

Genetics Home Reference: Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.17

Wikipedia: Asperger syndrome (AS), also known as Asperger\'s syndrome or Asperger disorder, is an autism spectrum...44 more...

Aliases & Descriptions for Asperger Syndrome

Sources:
6Disease Ontology, 16GeneTests, 17Genetics Home Reference, 31NINDS, 32Novoseek , 23MedlinePlus, 43UMLS, 33OMIM, 24MeSH
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Aliases & Descriptions:

asperger syndrome 6 16 17 31 32 43
asperger's syndrome 17 23

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Related Diseases for Asperger Syndrome

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13GeneCards, 14GeneDecks
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Diseases related to asperger syndrome by text searches and GeneDecks gene sharing:

(show all 30)
idRelated DiseaseScoreTop Affiliating Genes
1autistic disorder29.1MECP2, SLC6A4, OXT, NLGN3, NLGN4X
2pervasive developmental disorder28.6SLC6A4, NLGN4X, NLGN3, MECP2
3obsessive-compulsive disorder27.1OXT, SLC6A4, SGCE
4autism spectrum disorder26.1ASPG1, MECP2, DISC1, NLGN3, NLGN4X, SHANK3
5atypical autism13.1NLGN4X, NLGN3
6mecp2-related severe neonatal encephalopathy12.9OXT, MECP2
7social cognition12.8SLC6A4, OXT
8social phobia12.7SLC6A4, OXT
9postpartum depression12.7SLC6A4, OXT
10borderline personality disorder12.6SLC6A4, OXT
11phobia12.6SLC6A4, OXT
12growth mental deficiency syndrome of myhre12.5MECP2, SLC6A4
13anxiety disorder12.5OXT, SLC6A4
14mental retardation syndrome12.3NLGN4X, SHANK3, MECP2, NLGN3
15attention deficit hyperactivity disorder12.2SLC6A4, MECP2
16ppm-x syndrome12.2SLC6A4, OXT, DISC1
17schizoaffective disorder12.1DISC1, SHANK3, SLC6A4
18intellectual disability11.8MECP2, NLGN3, SHANK3, SLC6A4, NLGN4X
19tourette syndrome11.7NLGN4X, OXT, SGCE, SLC6A4
20mood disorder11.7DISC1, SLC6A4, OXT, SHANK3
21twinning11.4SLC6A4, OXT, MECP2, SGCE
22bipolar disorder11.3SLC6A4, DISC1, SHANK3, OXT
23schizophrenia10.1OXT, SHANK3, NLGN4X, MECP2, SGCE, DISC1
24asperger syndrome susceptibility 17.5
25asperger syndrome susceptibility 27.5
26asperger syndrome susceptibility 37.5
27asperger syndrome susceptibility 47.5
28asperger syndrome susceptibility, x-linked 17.5
29asperger syndrome susceptibility, x-linked 27.5
30congenital heart disease, atrial septal defect6.1

Graphical network of the top 20 diseases related to asperger syndrome:



Graphical network of diseases related to asperger syndrome

Clinical Features for Asperger Syndrome

Drugs & Therapeutics for Asperger Syndrome

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 43UMLS, 28NDF-RT
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Approved drugs:

Search CenterWatch for asperger syndrome

Drug clinical trials:

Search ClinicalTrials for asperger syndrome

Search NIH Clinical Center for asperger syndrome

Search CenterWatch for asperger syndrome

Genetic Tests for Asperger Syndrome

Anatomical Context for Asperger Syndrome

Phenotypes for genes affiliated with Asperger Syndrome

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25MGI
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MGI Mouse Phenotypes related to asperger syndrome:

25
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1nervous system phenotypeMP:00036318.8MECP2, DISC1, NLGN3, SLC6A4
2behavior/neurological phenotypeMP:00053866.6SGCE, SLC6A4, OXT, SHANK3, NLGN3, DISC1

Publications for genes affiliated with Asperger Syndrome

Sources:
35PubMed
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Articles related to asperger syndrome:

idTitleAuthorsYearAffiliating Genes
1Association of DISC1 with autism and Asperger syndrome. (17579608)Kilpinen H.... Peltonen L.2008DISC1
2SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder. (18197083)Wendland J.R.... Murphy D.L.2008SLC6A4, SGCE
3Asperger syndrome and high-functioning autism. (9614468)Gillberg C.1998ASPG3
4Asperger syndrome in a boy with a balanced de novo translocation: t(17;19)(p13.3;p11) (7778603)Anneren G.... Janols L.O.1995ASPG2

Expression for genes affiliated with Asperger Syndrome

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Asperger Syndrome

Pathways for genes affiliated with Asperger Syndrome

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10EMD Millipore
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Pathways related to asperger syndrome according to GeneDecks:

idPathwayScoreTop Affiliating Genes
1GABA signaling in brain109.5MECP2, NLGN3, NLGN4X

Compounds for genes affiliated with Asperger Syndrome

Sources:
32Novoseek , 34PharmGKB, 9DrugBank, 42Tocris Bioscience
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Compounds related to asperger syndrome according to GeneDecks:

idCompoundScoreTop Affiliating Genes
1fluoxetine32 34 9 9 12.5OXT, SLC6A4
2meperidine32 9 9 11.4OXT, SLC6A4
3gaba32 42 9.8MECP2, OXT, SLC6A4

GO Terms for genes affiliated with Asperger Syndrome

Sources:
12Gene Ontology
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Cellular components related to asperger syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.6NLGN3, NLGN4X
2postsynaptic membraneGO:0452118.8DISC1, NLGN4X, SHANK3
3postsynaptic densityGO:0140698.7SHANK3, NLGN4X, DISC1
4cell junctionGO:0300548.6DISC1, NLGN3, NLGN4X, SHANK3

Biological processes related to asperger syndrome according to GeneDecks:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.2NLGN4X, NLGN3
2synapse organizationGO:05080810.0NLGN4X, NLGN3
3regulation of respiratory gaseous exchange by neurological system processGO:00208710.0NLGN3, MECP2
4synapse assemblyGO:0074169.8MECP2, NLGN3
5sperm ejaculationGO:0427139.8OXT, SLC6A4
6regulation of long-term synaptic potentiationGO:19002719.7NLGN3, SHANK3
7cerebellum developmentGO:0215499.7MECP2, NLGN4X
8positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activityGO:20009699.7SHANK3, NLGN3
9vocalization behaviorGO:0716259.6SHANK3, NLGN4X
10regulation of dendritic spine morphogenesisGO:0610019.6SHANK3, NLGN3
11positive regulation of synapse assemblyGO:0519659.6OXT, NLGN3, MECP2
12positive regulation of excitatory postsynaptic membrane potentialGO:20004639.6SHANK3, NLGN3
13visual learningGO:0085429.5MECP2, NLGN3
14positive regulation of synaptic transmission, glutamatergicGO:0519689.5NLGN3, SHANK3
15response to electrical stimulusGO:0516029.4DISC1, OXT
16brain morphogenesisGO:0488549.3SHANK3, SLC6A4
17memoryGO:0076139.0SHANK3, OXT, SLC6A4
18social behaviorGO:0351768.0MECP2, NLGN3, NLGN4X, SHANK3, OXT, SLC6A4

Molecular functions related to asperger syndrome according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:0420439.9NLGN3, NLGN4X

Sources for Asperger Syndrome

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS