MCID: ASP001
MIFTS: 55

Asperger Syndrome malady

Genetic diseases, Rare diseases, Mental diseases, Fetal diseases categories
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Summaries for Asperger Syndrome

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NIH Rare Diseases:42 Asperger syndrome is a developmental disorder and falls within the autism spectrum disorders. however, unlike children with autism, children with asperger syndrome retain their early language skills. signs and symptoms of asperger syndrome may include obsessive interest in a particular topic or object, formal or advanced speech patterns, repetitive routines, peculiarities in speech and language, socially and emotionally inappropriate behavior, difficulty interacting with peers, difficulties with non-verbal communication, and often a history of delays in motor skills such as pedaling a bike, catching a ball, or climbing. last updated: 11/11/2009

MalaCards based summary: Asperger Syndrome, also known as asperger disorder, is related to atypical autism and attention deficit hyperactivity disorder. An important gene associated with Asperger Syndrome is NLGN3 (neuroligin 3), and among its related pathways are Ovarian steroidogenesis and Hormone ligand-binding receptors. The compounds selective serotonin reuptake inhibitors and venlafaxine have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related mouse phenotypes are hearing/vestibular/ear and normal.

Disease Ontology:8 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. it differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

NINDS:43 Asperger syndrome (AS) is a developmental disorder.

Genetics Home Reference:21 Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.

Wikipedia:65 Asperger syndrome (AS), also known as Asperger disorder (AD) or simply Asperger\'s, is an autism... more...

Descriptions from OMIM:46 608638, 300497, 608781, 608631, 300494 609954 more

Aliases & Classifications for Asperger Syndrome

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Asperger Syndrome, Aliases & Descriptions:

Name: Asperger Syndrome 8 42 21 43 10 44 62
Asperger Disorder 42 20 21
Asperger's Disease 21 62
 
Asperger's Syndrome 21
Asperger's Disorder 21
Asperger Disease 21


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases, Fetal diseases
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:0050432
MeSH34 D020817
ICD1025 F84.5

Related Diseases for Asperger Syndrome

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Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 51)
idRelated DiseaseScoreTop Affiliating Genes
1atypical autism30.7NLGN3, NLGN4X
2attention deficit hyperactivity disorder30.5MECP2, SLC6A4
3autistic disorder30.0SLC6A4, NLGN3, MECP2, HOXA1, NLGN4X
4autism spectrum disorder10.5
5asperger syndrome susceptibility, x-linked 210.5
6asperger syndrome susceptibility, x-linked 110.5
7learning disability10.4
8schizophrenia10.4
9eating disorder10.4SLC6A4
10prosopagnosia10.3
11obsessive-compulsive disorder10.3
12personality disorder10.3
13conduct disorder10.2
14gender identity disorder10.2
15myotonic dystrophy10.2
16epsilon-trimethyllysine hydroxylase deficiency10.2
17asperger syndrome susceptibility 310.2
18asperger syndrome susceptibility 410.2
19autism susceptibility 1610.2
20asperger syndrome susceptibility 110.2
21autism susceptibility 1510.2
22autism susceptibility 1710.2
23autism 1810.2
24asperger syndrome susceptibility 210.2
25autism susceptibility, x-linked 210.2
26autism susceptibility, x-linked 110.2
27autism susceptibility, x-linked 310.2
28autism x-linked 510.2
29fragile x syndrome10.2MECP2, SLC6A4
30intellectual disability multi-gene panels10.2NLGN4X, MECP2
31antisocial personality disorder10.1GABRA6, SLC6A4
32pervasive developmental disorder10.1MECP2, SLC6A4, NLGN4X
33hypogonadism10.1FSHB
34prader-willi syndrome10.0
35common variable immunodeficiency10.0
36cystic fibrosis10.0
37temporal lobe epilepsy10.0
38borderline personality disorder10.0
39alexithymia10.0
40cerebritis10.0
41anxiety disorder10.0
42astrocytoma10.0
43cerebellar astrocytoma10.0
44mood disorder10.0
45psychotic disorder10.0
46writing disorder10.0
47hypercholesterolemia10.0
48synesthesia10.0
49blindness10.0
50alcohol dependence9.9GABRA6, SLC6A4

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to asperger syndrome

Symptoms for Asperger Syndrome

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Clinical features from OMIM:

608638,300497,608781,608631,300494,609954

Drugs & Therapeutics for Asperger Syndrome

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Drug clinical trials:

Search ClinicalTrials for Asperger Syndrome

Search NIH Clinical Center for Asperger Syndrome

Genetic Tests for Asperger Syndrome

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Genetic tests related to Asperger Syndrome:

id Genetic test Affiliating Genes
1 Asperger Disorder20

Anatomical Context for Asperger Syndrome

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MalaCards organs/tissues related to Asperger Syndrome:

32
Testes, Brain, Eye, Amygdala, Cortex, Skin, Prefrontal cortex, Temporal lobe

Animal Models for Asperger Syndrome or affiliated genes

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MGI Mouse Phenotypes related to Asperger Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053779.2GABRA6, MECP2, HOXA1
2MP:00028738.2HOXA1, MECP2, NLGN3, GABRA6, SLC6A4
3MP:00053797.5AVPR1B, HOXA1, LHB, FSHB, MECP2, SLC6A4
4MP:00053867.5SLC6A4, AVPR1B, HOXA1, MECP2, NTF4, NLGN3
5MP:00036317.4AVPR1B, HOXA1, MECP2, NTF4, NLGN3, GABRA6
6MP:00053766.8AVPR1B, HOXA1, LHB, FSHB, MECP2, GABRA6

Publications for Asperger Syndrome

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Articles related to Asperger Syndrome:

(show top 50)    (show all 436)
idTitleAuthorsYear
1
I Collect Therefore I am-Autonoetic Consciousness and Hoarding in Asperger Syndrome. (24615808)
2014
2
The neuropsychology of male adults with high-functioning autism or asperger syndrome. (24903974)
2014
3
Neurological abnormalities in recent-onset schizophrenia and asperger-syndrome. (25147527)
2014
4
Gaze and visual search strategies of children with Asperger syndrome/high functioning autism viewing a magic trick. (24866104)
2014
5
Asperger syndrome related suicidal behavior: two case studies. (24294002)
2013
6
Early identification of Asperger syndrome in young children. (23123877)
2013
7
Did Mozart suffer from Asperger syndrome? (24585598)
2013
8
Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. (21824190)
2012
9
Narrative competence and internal state language of children with Asperger Syndrome and ADHD. (22522198)
2012
10
"We are all there silently coping." The hidden experiences of parents of adults with Asperger syndrome. (22852754)
2012
11
Mosaic partial trisomy 19p12-q13.11 due to a small supernumerary marker chromosome: a locus associated with Asperger syndrome? (21815264)
2011
12
Asperger syndrome and the supposed obligation not to bring disabled lives into the world. (20675739)
2010
13
Executive functioning in children with Asperger syndrome, ADHD-combined type, ADHD-predominately inattentive type, and controls. (20140638)
2010
14
Asperger syndrome in adolescent and young adult males. Interview, self- and parent assessment of social, emotional, and cognitive problems. (19880274)
2010
15
Comorbid psychiatric disorders associated with Asperger syndrome/high-functioning autism: a community- and clinic-based study. (20177765)
2010
16
Asperger syndrome, violent thoughts and clinically isolated syndrome. (21305864)
2010
17
A descriptive social and health profile of a community sample of adults and adolescents with Asperger syndrome. (21070680)
2010
18
Maturation of limbic regions in Asperger syndrome: a preliminary study using proton magnetic resonance spectroscopy and structural magnetic resonance imaging. (20952166)
2010
19
Pragmatic inferences in high-functioning adults with autism and Asperger syndrome. (19052858)
2009
20
The anatomy of extended limbic pathways in Asperger syndrome: a preliminary diffusion tensor imaging tractography study. (19446642)
2009
21
Social challenges and supports from the perspective of individuals with Asperger syndrome and other autism spectrum disabilities. (18308766)
2008
22
Sleep in children with Asperger syndrome. (17340201)
2008
23
Disembedding performance in children and adolescents with Asperger syndrome or high-functioning autism. (17175576)
2007
24
Answering contextually demanding questions: pragmatic errors produced by children with Asperger syndrome or high-functioning autism. (17126362)
2007
25
Autobiographical memory and social problem-solving in Asperger syndrome. (16874561)
2007
26
Brief report: social and communication abilities and disabilities in higher functioning individuals with autism and Asperger syndrome. (17160458)
2007
27
Effects of vagus nerve stimulation in a patient with temporal lobe epilepsy and Asperger syndrome: case report and review of the literature. (17300990)
2007
28
Sleep architecture and NREM alterations in children and adolescents with Asperger syndrome. (18041490)
2007
29
Sleep patterns of school-age children with Asperger syndrome or high-functioning autism. (16617404)
2006
30
Independent replication and initial fine mapping of 3p21-24 in Asperger syndrome. (16467216)
2006
31
Monozygotic twins with Asperger syndrome: differences in behaviour reflect variations in brain structure and function. (16459007)
2006
32
Diagnosis of Asperger syndrome in a 66-year-old male presenting with depression. (16734928)
2006
33
Understanding and negotiating friendships: perspectives from an adolescent with Asperger syndrome. (17088277)
2006
34
The Strange Stories test--a replication study of children and adolescents with Asperger syndrome. (15793686)
2005
35
An experimental investigation of the phenomenology of delusional beliefs in people with Asperger syndrome. (16287703)
2005
36
Higher plasma ACTH levels in adults with Asperger syndrome. (16125520)
2005
37
Finding meaning in parenting a child with Asperger syndrome: correlates of sense making and benefit finding. (15134791)
2004
38
Outcome in high-functioning adults with autism with and without early language delays: implications for the differentiation between autism and Asperger syndrome. (12708575)
2003
39
Deficient auditory processing in children with Asperger Syndrome, as indexed by event-related potentials. (12581830)
2003
40
Outcome research in Asperger syndrome and autism. (12512398)
2003
41
Psychosocial functioning in a group of Swedish adults with Asperger syndrome or high-functioning autism. (12638767)
2003
42
Misdiagnosis of Asperger syndrome as anankastic personality disorder. (12540134)
2002
43
Asperger syndrome: a proton magnetic resonance spectroscopy study of brain. (12365875)
2002
44
Temperament and character in adults with Asperger syndrome. (12212919)
2002
45
Asperger syndrome: tests of right hemisphere functioning and interhemispheric communication. (12199132)
2002
46
Speech and prosody characteristics of adolescents and adults with high-functioning autism and Asperger syndrome. (11708530)
2001
47
The Strange Stories Test: a replication with high-functioning adults with autism or Asperger syndrome. (10587886)
1999
48
Brief report: autism and Asperger syndrome in seven-year-old children: a total population study. (10478732)
1999
49
Recognition of faux pas by normally developing children and children with Asperger syndrome or high-functioning autism. (10587887)
1999
50
Developmental prosopagnosia in Asperger syndrome: presentation and discussion of an individual case. (7926319)
1994

Variations for Asperger Syndrome

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Expression for genes affiliated with Asperger Syndrome

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Expression patterns in normal tissues for genes affiliated with Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for genes affiliated with Asperger Syndrome

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Compounds for genes affiliated with Asperger Syndrome

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Compounds related to Asperger Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1selective serotonin reuptake inhibitors509.7SLC6A4, GABRA6
2venlafaxine44 50 24 1112.6SLC6A4, GABRA6
3gaba449.2MECP2, GABRA6, SLC6A4
4corticosterone44 61 2411.2AVPR1B, SLC6A4
5gnrh448.9SLC6A4, FSHB, LHB
6testosterone44 61 24 1111.9SLC6A4, MECP2, FSHB
7arginine448.5SLC6A4, NTF4, MECP2, AVPR1B

GO Terms for genes affiliated with Asperger Syndrome

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Cellular components related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1excitatory synapseGO:0600769.6NLGN3, NLGN4X
2cell junctionGO:0300549.3GABRA6, NLGN4X, NLGN3
3integral component of plasma membraneGO:0058878.2SLC6A4, GABRA6, NLGN4X, NLGN3, AVPR1B

Biological processes related to Asperger Syndrome according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1presynaptic membrane assemblyGO:09710510.1NLGN4X, NLGN3
2vocalization behaviorGO:07162510.1NLGN3, NLGN4X
3neuron cell-cell adhesionGO:00715810.1NLGN4X, NLGN3
4regulation of respiratory gaseous exchange by neurological system processGO:00208710.1NLGN3, MECP2
5adult behaviorGO:03053410.0NLGN3, NLGN4X
6positive regulation of synapse assemblyGO:05196510.0MECP2, NLGN3
7synapse organizationGO:05080810.0NLGN4X, NLGN3
8cerebellum developmentGO:0215499.9NLGN4X, MECP2
9visual learningGO:0085429.8MECP2, NLGN3
10learningGO:0076129.8NLGN4X, NLGN3
11long-term memoryGO:0076169.7NTF4, MECP2
12adult locomotory behaviorGO:0083449.6NTF4, MECP2
13synapse assemblyGO:0074169.5NLGN3, MECP2
14progesterone biosynthetic processGO:0067019.5FSHB, LHB
15social behaviorGO:0351769.4SLC6A4, NLGN4X, NLGN3, MECP2
16peptide hormone processingGO:0164869.4FSHB, LHB

Molecular functions related to Asperger Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1neurexin family protein bindingGO:0420439.8NLGN4X, NLGN3
2cell adhesion molecule bindingGO:0508399.6NLGN4X, NLGN3
3hormone activityGO:0051799.2FSHB, LHB

Products for genes affiliated with Asperger Syndrome

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Sources for Asperger Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet