ASPX1
MCID: ASP001
MIFTS: 50

Asperger Syndrome (ASPX1) malady

Categories: Rare diseases, Mental diseases, Genetic diseases

Aliases & Classifications for Asperger Syndrome

Aliases & Descriptions for Asperger Syndrome:

Name: Asperger Syndrome 12 50 24 25 51 52 42 14 69
Asperger Disorder 50 24 25
Asperger's Syndrome 25 29
Asperger Syndrome Susceptibility, X-Linked 24
Asperger's Disorder 25
Asperger's Disease 25
Asperger Disease 25
Aspx1 24

Classifications:



External Ids:

Disease Ontology 12 DOID:0050432
ICD10 33 F84.5
MeSH 42 D020817
NCIt 47 C97159
UMLS 69 C0236792

Summaries for Asperger Syndrome

NIH Rare Diseases : 50 asperger syndrome (as) is an autism spectrum disorder, a type of neurological condition characterized by impaired language and communication skills, and repetitive or restrictive thought and behavior patterns. unlike many people with autism, those with as retain their early language skills. features of as include an obsessive interest in a particular object or topic; high vocabulary; formal speech patterns; repetitive routines or habits; inappropriate social and emotional behavior; impaired non-verbal communication; and uncoordinated motor skills. as is likely caused by a combination of genetic and environmental influences. while autism spectrum disorders including as sometimes run in families, no specific inheritance pattern has been recognized. last updated: 6/8/2015

MalaCards based summary : Asperger Syndrome, also known as asperger disorder, is related to personality disorder and schizophrenia. An important gene associated with Asperger Syndrome is NLGN3 (Neuroligin 3), and among its related pathways/superpathways are Transmission across Chemical Synapses and Calcium signaling pathway. The drugs Dopamine and Risperidone have been mentioned in the context of this disorder. Affiliated tissues include testes, brain and eye, and related phenotypes are behavior/neurological and nervous system

NINDS : 51 Asperger syndrome (AS) is a developmental disorder.  It is an autism spectrum disorder (ASD), one of a distinct group of neurological conditions characterized by a greater or lesser degree of impairment in language and communication skills, as well as repetitive or restrictive patterns of thought and behavior.  Other ASDs include:  classic autism, Rett syndrome, childhood disintegrative disorder, and pervasive developmental disorder not otherwise specified (usually referred to as PDD-NOS). Unlike children with autism, children with AS retain their early language skills.

Genetics Home Reference : 25 Asperger syndrome is a disorder on the autism spectrum, which is a group of conditions characterized by impaired communication and social interaction. Asperger syndrome is on the mild, or "high-functioning," end of the autism spectrum. Many affected individuals learn to compensate for their differences and live independent and successful lives. However, the behavioral challenges associated with this condition often lead to social isolation and difficulties at school, at work, and in personal relationships.

Disease Ontology : 12 An autism spectrum disorder that is characterized by significant difficulties in social interaction, along with restricted and repetitive patterns of behavior and interests. It differs from other autism spectrum disorders by its relative preservation of linguistic and cognitive development.

Wikipedia : 71 Asperger syndrome (AS), also known as Asperger\'s, is a developmental disorder characterized by... more...

Related Diseases for Asperger Syndrome

Diseases related to Asperger Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
id Related Disease Score Top Affiliating Genes
1 personality disorder 29.7 DISC1 SHANK3 SLC6A4
2 schizophrenia 29.6 DISC1 GABRB3 OXTR SHANK3 SLC6A4
3 asperger syndrome susceptibility, x-linked 1 12.2
4 asperger syndrome susceptibility, x-linked 2 12.2
5 autism spectrum disorder 11.2
6 autism susceptibility, x-linked 2 10.9
7 autism x-linked 4 10.9
8 autism susceptibility, x-linked 1 10.9
9 autism susceptibility 16 10.9
10 autism susceptibility, x-linked 3 10.9
11 autism x-linked 5 10.9
12 autism 9 10.9
13 epsilon-trimethyllysine hydroxylase deficiency 10.9
14 autism susceptibility 15 10.9
15 autism 10 10.9
16 autism susceptibility 17 10.9
17 autism 18 10.9
18 pervasive developmental disorder 10.7
19 munchausen by proxy 10.1 NLGN3 NLGN4X OXTR
20 active cochlear meniere's disease 10.0 GABRB3 SHANK3
21 apperceptive agnosia 10.0 OXTR SLC6A4
22 learning disability 10.0
23 epileptic encephalopathy, early infantile, 26 10.0 AVPR1A AVPR1B
24 bartter disease 9.9 GABRB3 NLGN3 NLGN4X OXTR SLC6A4
25 attention deficit-hyperactivity disorder 9.8
26 obsessive-compulsive disorder 9.8
27 prosopagnosia 9.8
28 chronic conjunctivitis 9.8 DISC1 GABRB3 SHANK3 SLC6A4
29 myotonic dystrophy 9.8
30 specific language impairment 9.8
31 gender identity disorder 9.8
32 conduct disorder 9.8
33 anxiety disorder 9.8
34 anorexia nervosa 9.8
35 atypical autism 9.8
36 sexual disorder 9.7 GABRB3 NLGN3 NLGN4X OXTR SHANK3 SLC6A4
37 prader-willi syndrome 9.6
38 alexithymia 9.6
39 stuttering 9.6
40 developmental prosopagnosia 9.6
41 borderline personality disorder 9.6
42 synesthesia 9.6
43 epilepsy 9.6
44 cystic fibrosis 9.6
45 common variable immunodeficiency 9.6
46 psychotic disorder 9.6
47 crohn's disease 9.6
48 astrocytoma 9.6
49 temporal lobe epilepsy 9.6
50 mood disorder 9.6

Graphical network of the top 20 diseases related to Asperger Syndrome:



Diseases related to Asperger Syndrome

Symptoms & Phenotypes for Asperger Syndrome

MGI Mouse Phenotypes related to Asperger Syndrome:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.7 AVPR1A AVPR1B CYP11B1 DISC1 GABRB3 NLGN3
2 nervous system MP:0003631 9.36 ARNT2 AVPR1A AVPR1B DISC1 GABRB3 NLGN3

Drugs & Therapeutics for Asperger Syndrome

Drugs for Asperger Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
3
Milnacipran Approved Phase 4 92623-85-3 65833
4
Guanfacine Approved, Investigational Phase 4 29110-47-2 3519
5
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
6
Choline Approved, Nutraceutical Phase 4 62-49-7 305
7
Creatine Approved, Nutraceutical Phase 4 57-00-1 586
8 Antibodies Phase 4
9 gamma-Globulins Phase 4
10 Immunoglobulins Phase 4
11 Immunoglobulins, Intravenous Phase 4
12 Rho(D) Immune Globulin Phase 4
13 Dopamine Agents Phase 4,Phase 3,Phase 2
14 Neurotransmitter Agents Phase 4,Phase 3,Phase 2
15 Antipsychotic Agents Phase 4,Phase 3,Phase 2
16 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
17 Dopamine Antagonists Phase 4,Phase 3,Phase 2
18
Phosphocreatine Phase 4 67-07-2 587
19 Psychotropic Drugs Phase 4,Phase 3,Phase 2
20
Serotonin Phase 4,Phase 3,Phase 2 50-67-9 5202
21 Serotonin Agents Phase 4,Phase 3,Phase 2
22 Serotonin Antagonists Phase 4,Phase 3,Phase 2
23 Tranquilizing Agents Phase 4,Phase 3,Phase 2
24 Adrenergic Agents Phase 4,Phase 3,Phase 2
25 Antidepressive Agents Phase 4,Phase 3,Phase 2
26 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
27 Serotonin Uptake Inhibitors Phase 4,Phase 2
28 Atomoxetine Hydrochloride Phase 4,Phase 3
29 Adrenergic Agonists Phase 4
30 Adrenergic alpha-2 Receptor Agonists Phase 4
31 Adrenergic alpha-Agonists Phase 4
32 Antihypertensive Agents Phase 4
33 Central Nervous System Stimulants Phase 4
34 Dopamine Uptake Inhibitors Phase 4
35
Cycloserine Approved Phase 3 68-41-7 401 6234
36
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
37
Mianserin Approved Phase 3 24219-97-4 4184
38
Mirtazapine Approved Phase 3 85650-52-8, 61337-67-5 4205
39
Ziprasidone Approved Phase 3 146939-27-7 60854
40 Anti-Bacterial Agents Phase 3
41 Antibiotics, Antitubercular Phase 3
42 Anti-Infective Agents Phase 3,Phase 2
43 Antimetabolites Phase 3
44 Antitubercular Agents Phase 3
45 Renal Agents Phase 3
46 Adrenergic alpha-Antagonists Phase 3,Phase 2
47 Adrenergic Antagonists Phase 3,Phase 2
48 Antidepressive Agents, Second-Generation Phase 3,Phase 2
49 Antidepressive Agents, Tricyclic Phase 3
50 Histamine Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 81)
id Name Status NCT ID Phase
1 An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum Unknown status NCT02199925 Phase 4
2 Janssen Asperger's MRS (Magnetic Resonance Spectroscopy Risperidone Study Completed NCT00352196 Phase 4
3 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4
4 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4
5 Guanfacine for the Treatment of Hyperactivity in Pervasive Developmental Disorder Completed NCT01238575 Phase 4
6 Methylphenidate ER Liquid Formulation in Adults With ASD and ADHD Recruiting NCT02096952 Phase 4
7 Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism Completed NCT00498173 Phase 3
8 D-Cycloserine and Social Skills Training in Autism Spectrum Disorders Completed NCT01086475 Phase 3
9 Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01178385 Phase 2, Phase 3
10 A Study of the Effectiveness and Safety of Risperidone Versus Placebo in the Treatment of Children With Autistic Disorder and Other Pervasive Developmental Disorders (PDD) Completed NCT00261508 Phase 3
11 Mirtazapine Treatment of Anxiety in Children and Adolescents With Pervasive Developmental Disorders Recruiting NCT01302964 Phase 3
12 Psychotherapy for Anxiety in Children With Autism Spectrum Disorder Recruiting NCT02028247 Phase 3
13 Deep rTMS (Repetitive Transcranial Magnetic Stimulation)for Treatment of Autism Symptoms in Children. Unknown status NCT01388179 Phase 2
14 An Open-Label Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Completed NCT01592786 Phase 2
15 Withdrawal Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder, or Pervasive Developmental Disorder Not Otherwise Specified Previously Treated With Memantine Completed NCT01592747 Phase 2
16 CBT for Comorbid Anxiety Disorders in Children With Autism, Asperger Syndrome, or PDD-NOS Completed NCT00280670 Phase 2
17 The Development of Autistic Children Based on Mothers´Response in Autism Behavior Checklist Completed NCT00725556 Phase 1, Phase 2
18 Cognitive Behavioral Therapy (CBT) for Anxiety Disorders in Autism: Adapting Treatment for Adolescents Completed NCT01177969 Phase 1, Phase 2
19 A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder. Completed NCT00198055 Phase 2
20 A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Completed NCT00453180 Phase 2
21 Study of Aripiprazole to Treat Children and Adolescents With Autism Completed NCT00619190 Phase 2
22 Cholesterol in ASD: Characterization and Treatment Completed NCT00965068 Phase 1, Phase 2
23 An Open-Label Trial of Aripiprazole in Autism Spectrum Disorders Completed NCT00308074 Phase 2
24 Omega-3 Fatty Acids For Treatment Of Young Children With Autism (OMG) Completed NCT01248728 Phase 2
25 Study of Arbaclofen for the Treatment of Social Withdrawal in Subjects With Autism Spectrum Disorders Completed NCT01288716 Phase 2
26 My Scrivener® - Measuring Effectiveness and Dose Response in Children Completed NCT00919906 Phase 1, Phase 2
27 Riluzole to Treat Child and Adolescent Obsessive-Compulsive Disorder With or Without Autism Spectrum Disorders Completed NCT00251303 Phase 2
28 Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Completed NCT01731119 Phase 2
29 Citalopram for Children With Autism and Repetitive Behavior (STAART Study 1) Completed NCT00086645 Phase 2
30 Safety Study of Memantine in Pediatric Patients With Autism, Asperger's Disorder or Pervasive Developmental Disorder Not Otherwise Specified (PDD-NOS) Terminated NCT01592773 Phase 2
31 Transcranial Magnetic Stimulation for Evaluation and Treatment of Repetetive Behaviors in Autism Terminated NCT01983189 Phase 2
32 A Folinic Acid Intervention for Autism Spectrum Disorders Terminated NCT01602016 Phase 2
33 Mercury Chelation to Treat Autism Withdrawn NCT00376194 Phase 2
34 Cognitive-Behavioral Therapy for Children With High-Functioning Autism Spectrum Disorder and Anxiety Completed NCT01187784 Phase 1
35 Evaluation of the French Version of Screening Questionnaires for Autism and Asperger Syndrome: AQ, EQ and SQ Unknown status NCT00505830
36 Portable Visual Guidance System Phase II Unknown status NCT00848874
37 Memantine in Adult Autism Spectrum Disorder Unknown status NCT01078844
38 Adolescent Social Skills Training Program Unknown status NCT01031823
39 Cognitive-Behavioral Therapy for Irritability in Adolescents With High Functioning Autism Spectrum Disorder Unknown status NCT01631851
40 A Non-Drug Study on the Relationship Between Exploratory Biomarkers and Functional Dimensions in Individuals With Autistic Disorder or Asperger's Syndrome Completed NCT01669889
41 The Use of rTMS to Improve Theory of Mind Among Adults With Autism and Asperger's Disorder Completed NCT00808782
42 Validation of the French Adaptation of the RAADS-R Scale : Scale of Asperger Syndrome Diagnosis Completed NCT02826148
43 Psychometric Studies of the Chinese Versions of the SRS, CAST, and AQ Completed NCT01247662
44 Functional Magnetic Resonance Imaging (fMRI) for the Study of Response Inhibition, and Face and Linguistic Processing in Autism Completed NCT00211783
45 Cognitive Behavioural Therapy (CBT) and Recreational Activity for Autism Spectrum Disorders (ASD) Completed NCT01655173
46 Advanced Grandparental Age as a Risk Factor for Autism Completed NCT00464477
47 Predictors of Caregiver Adaptation to Pervasive Developmental Disorders Completed NCT00496210
48 RUPP PI PDD: Drug and Behavioral Therapy for Children With Pervasive Developmental Disorders Completed NCT00080145
49 Computer- Assisted Cognitive-Behavioral Treatment for Anxiety Disorders in Children With Autism Spectrum Disorders Completed NCT01565629
50 Cognitive Behavioral Therapy for Anxiety Disorders in Adolescents With Autism Completed NCT01563003

Search NIH Clinical Center for Asperger Syndrome

Cochrane evidence based reviews: asperger syndrome

Genetic Tests for Asperger Syndrome

Genetic tests related to Asperger Syndrome:

id Genetic test Affiliating Genes
1 Asperger's Disease 29
2 Asperger Disorder 24 NLGN3

Anatomical Context for Asperger Syndrome

MalaCards organs/tissues related to Asperger Syndrome:

39
Testes, Brain, Eye, Amygdala, Skin, Cortex, Temporal Lobe

Publications for Asperger Syndrome

Articles related to Asperger Syndrome:

(show top 50) (show all 471)
id Title Authors Year
1
A Case of Asperger Syndrome With Comorbidity of Posttraumatic Stress Disorder and Selective Mutism: Significant Remission With the Combination of Aripiprazole and Eye Movement Desensitization and Reprocessing. ( 27977468 )
2017
2
Impaired social cognition processes in Asperger syndrome and anorexia nervosa. In search for endophenotypes of social cognition. ( 27556112 )
2016
3
Do Adults with High Functioning Autism or Asperger Syndrome Differ in Empathy and Emotion Recognition? ( 26883645 )
2016
4
The Occupational Transition Process to Upper Secondary School, Further Education and/or Work in Sweden: As Described by Young Adults with Asperger Syndrome and Attention Deficit Hyperactivity Disorder. ( 28005233 )
2016
5
Romantic Relationships and Relationship Satisfaction Among Adults With Asperger Syndrome and High-Functioning Autism. ( 27196958 )
2016
6
Asperger syndrome in males over two decades: Quality of life in relation to diagnostic stability and psychiatric comorbidity. ( 27233289 )
2016
7
Neuroanatomical Markers of Neurological Soft Signs in Recent-Onset Schizophrenia and Asperger-Syndrome. ( 26708327 )
2016
8
The People with Asperger syndrome and anxiety disorders (PAsSA) trial: a pilot multicentre, single-blind randomised trial of group cognitive-behavioural therapy. ( 27703772 )
2016
9
Asperger Syndrome and Schizophrenia: A Comparative Neuropsychological Study. ( 26936160 )
2016
10
Age-related differences in inhibitory control and memory updating in boys with Asperger syndrome. ( 28025692 )
2016
11
Asperger syndrome in childhood - personality dimensions in adult life: temperament, character and outcome trajectories. ( 27703778 )
2016
12
Crohn's Disease and Asperger Syndrome: Not Just a Coincidence? ( 27104829 )
2016
13
Exploratory Study of Childbearing Experiences of Women With Asperger Syndrome. ( 26902438 )
2016
14
Effects of multisensory yoga on behavior in a male child with Apert and Asperger syndrome. ( 26865777 )
2016
15
From High Intellectual Potential to Asperger Syndrome: Evidence for Differences and a Fundamental Overlap-A Systematic Review. ( 27812341 )
2016
16
3p22.1p21.31 microdeletion identifies CCK as Asperger syndrome candidate gene and shows the way for therapeutic strategies in chromosome imbalances. ( 26523151 )
2015
17
Asperger syndrome in India: findings from a case-series with respect to clinical profile and comorbidity. ( 25969609 )
2015
18
Repetition, response mobilization, and face: Analysis of group interactions with a 19-year-old with Asperger syndrome. ( 26026646 )
2015
19
Early-onset anorexia nervosa in girls with Asperger syndrome. ( 26170676 )
2015
20
Incidental diagnosis of HLRCC following investigation for Asperger Syndrome: actionable and actioned. ( 26275867 )
2015
21
Substance use disorder in Asperger syndrome: An investigation into the development and maintenance of substance use disorder by individuals with a diagnosis of Asperger syndrome. ( 26187185 )
2015
22
Constrained spherical deconvolution-based tractography and tract-based spatial statistics show abnormal microstructural organization in Asperger syndrome. ( 25874076 )
2015
23
Correlation between chromatic sensitivity and higher order color vision functions in Asperger Syndrome but not in high functioning autism. ( 26325950 )
2015
24
Evaluation of Asperger Syndrome in Youth Presenting to a Gender Dysphoria Clinic. ( 26651183 )
2015
25
Boys with Asperger Syndrome Grow Up: Psychiatric and Neurodevelopmental Disorders 20A Years After Initial Diagnosis. ( 26210519 )
2015
26
Genetic variant rs17225178 in the ARNT2 gene is associated with Asperger Syndrome. ( 25745553 )
2015
27
A Pooled Genome-Wide Association Study of Asperger Syndrome. ( 26176695 )
2015
28
The Puberty Video for Boys with Asperger Syndrome (and Autism Spectrum Disorder: Level 1) DVD $25.00, 48A Minutes and Managing Puberty, Social Challenges, and (Almost) Everything: A Video Guide for Girls: DVD, $25.00, 80 Minutes; Coulter Video (http://coultervideo.com). ( 25432100 )
2015
29
Late diagnosis of Asperger syndrome in Croatia - a low-income country. ( 26609658 )
2015
30
A Concise History of Asperger Syndrome: The Short Reign of a Troublesome Diagnosis. ( 26834663 )
2015
31
Beyond childhood: psychiatric comorbidities and social background of adults with Asperger syndrome. ( 25751431 )
2015
32
Asperger syndrome and schizophrenia: Overlap of self-reported autistic traits using the Autism-spectrum Quotient (AQ). ( 25389915 )
2014
33
Micturition Difficulty and Urinary Retention Associated with Aripiprazole and Citalopram Treatment in a Male Adolescent with Asperger Syndrome. ( 24511913 )
2014
34
Group training in interpersonal problem-solving skills for workplace adaptation of adolescents and adults with Asperger syndrome: A preliminary study. ( 24569569 )
2014
35
Neurological abnormalities in recent-onset schizophrenia and asperger-syndrome. ( 25147527 )
2014
36
The effect of bumetanide treatment on the sensory behaviours of a young girl with Asperger syndrome. ( 24488662 )
2014
37
Oxytocin promotes facial emotion recognition and amygdala reactivity in adults with asperger syndrome. ( 24067301 )
2014
38
Gaze and visual search strategies of children with Asperger syndrome/high functioning autism viewing a magic trick. ( 24866104 )
2014
39
Piloting the use of experience sampling method to investigate the everyday social experiences of children with Asperger syndrome/high functioning autism. ( 24840290 )
2014
40
Single nucleotide polymorphism rs6716901 in SLC25A12 gene is associated with Asperger syndrome. ( 24679184 )
2014
41
The neuropsychology of male adults with high-functioning autism or asperger syndrome. ( 24903974 )
2014
42
History of suicide attempts in adults with Asperger syndrome. ( 25113892 )
2014
43
Asperger syndrome in males over two decades: stability and predictors of diagnosis. ( 25283685 )
2014
44
Automatic conversational scene analysis in children with Asperger syndrome/high-functioning autism and typically developing peers. ( 24489674 )
2014
45
An investigation of the "jumping to conclusions" data-gathering bias and paranoid thoughts in asperger syndrome. ( 23933997 )
2014
46
Genetic variation in the oxytocin receptor (OXTR) gene is associated with Asperger Syndrome. ( 25264479 )
2014
47
Asperger syndrome and nonverbal learning difficulties in adult males: self- and parent-reported autism, attention and executive problems. ( 25399237 )
2014
48
I Collect Therefore I am-Autonoetic Consciousness and Hoarding in Asperger Syndrome. ( 24615808 )
2014
49
Serum proteomic analysis identifies sex-specific differences in lipid metabolism and inflammation profiles in adults diagnosed with Asperger syndrome. ( 24467795 )
2014
50
Atypical prosody in Asperger syndrome: perceptual and acoustic measurements. ( 24590408 )
2014

Variations for Asperger Syndrome

Expression for Asperger Syndrome

Search GEO for disease gene expression data for Asperger Syndrome.

Pathways for Asperger Syndrome

Pathways related to Asperger Syndrome according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1
Show member pathways
11.88 GABRB3 NLGN3 NLGN4X SHANK3 SLC6A4
2
Show member pathways
11.6 AVPR1A AVPR1B OXTR
3
Show member pathways
11.25 NLGN3 NLGN4X SHANK3

GO Terms for Asperger Syndrome

Cellular components related to Asperger Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 9.85 AVPR1A AVPR1B DISC1 GABRB3 NLGN3 NLGN4X
2 synapse GO:0045202 9.67 DISC1 GABRB3 NLGN3 NLGN4X
3 cell junction GO:0030054 9.65 DISC1 GABRB3 NLGN3 NLGN4X SHANK3
4 postsynaptic density GO:0014069 9.58 DISC1 NLGN4X SHANK3
5 excitatory synapse GO:0060076 9.32 NLGN3 NLGN4X
6 postsynaptic membrane GO:0045211 9.26 DISC1 GABRB3 NLGN4X SHANK3
7 integral component of plasma membrane GO:0005887 9.23 AVPR1A AVPR1B GABRB3 NLGN3 NLGN4X OXTR

Biological processes related to Asperger Syndrome according to GeneCards Suite gene sharing:

(show all 29)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cytosolic calcium ion concentration GO:0007204 9.78 AVPR1A AVPR1B OXTR
2 response to estradiol GO:0032355 9.74 ARNT2 OXTR SLC6A4
3 memory GO:0007613 9.7 OXTR SHANK3 SLC6A4
4 learning GO:0007612 9.69 NLGN3 NLGN4X SHANK3
5 synapse organization GO:0050808 9.64 NLGN3 NLGN4X
6 long-term synaptic potentiation GO:0060291 9.64 NLGN3 SHANK3
7 telencephalon development GO:0021537 9.63 AVPR1A OXTR
8 activation of phospholipase C activity GO:0007202 9.63 AVPR1A AVPR1B
9 positive regulation of vasoconstriction GO:0045907 9.63 AVPR1A AVPR1B OXTR
10 regulation of synaptic transmission, glutamatergic GO:0051966 9.62 DISC1 NLGN3
11 positive regulation of excitatory postsynaptic potential GO:2000463 9.62 NLGN3 SHANK3
12 positive regulation of blood pressure GO:0045777 9.61 AVPR1A OXTR
13 adult behavior GO:0030534 9.61 NLGN3 NLGN4X SHANK3
14 brain morphogenesis GO:0048854 9.6 SHANK3 SLC6A4
15 neuron cell-cell adhesion GO:0007158 9.59 NLGN3 NLGN4X
16 regulation of dendritic spine morphogenesis GO:0061001 9.58 NLGN3 SHANK3
17 maternal behavior GO:0042711 9.58 AVPR1A OXTR
18 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.58 NLGN3 OXTR SHANK3
19 negative regulation of excitatory postsynaptic potential GO:0090394 9.56 NLGN3 NLGN4X
20 cellular response to hormone stimulus GO:0032870 9.56 AVPR1A AVPR1B CYP11B1 OXTR
21 presynaptic membrane assembly GO:0097105 9.55 NLGN3 NLGN4X
22 inhibitory postsynaptic potential GO:0060080 9.54 GABRB3 NLGN3
23 response to peptide GO:1901652 9.54 AVPR1A AVPR1B OXTR
24 vocalization behavior GO:0071625 9.5 NLGN3 NLGN4X SHANK3
25 regulation of long-term synaptic potentiation GO:1900271 9.49 NLGN3 SHANK3
26 positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity GO:2000969 9.48 NLGN3 SHANK3
27 sperm ejaculation GO:0042713 9.33 AVPR1A OXTR SLC6A4
28 regulation of systemic arterial blood pressure by vasopressin GO:0001992 9.13 AVPR1A AVPR1B OXTR
29 social behavior GO:0035176 9.1 AVPR1A NLGN3 NLGN4X OXTR SHANK3 SLC6A4

Molecular functions related to Asperger Syndrome according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 peptide binding GO:0042277 9.33 AVPR1A AVPR1B OXTR
2 peptide hormone binding GO:0017046 9.32 AVPR1A OXTR
3 neurexin family protein binding GO:0042043 9.26 NLGN3 NLGN4X
4 scaffold protein binding GO:0097110 9.13 NLGN3 NLGN4X SHANK3
5 vasopressin receptor activity GO:0005000 8.8 AVPR1A AVPR1B OXTR

Sources for Asperger Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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