MCID: ASP006
MIFTS: 73

Aspergillosis malady

Rare diseases, Infectious diseases categories
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Summaries for Aspergillosis

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NIH Rare Diseases:42 Aspergillosis is an infection, growth, or allergic response caused by the aspergillus fungus. there are several different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. another kind of aspergillosis is invasive aspergillosis. this infection usually affects people with weakened immune systems due to cancer, aids, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. in this condition, the fungus invades and damages tissues in the body. invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. this type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. the fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. last updated: 10/2/2013

MalaCards based summary: Aspergillosis, also known as infection due to aspergillus, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis. An important gene associated with Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Legionellosis and Cytokine production by Th17 cells in CF. The drugs flucytosine and miconazole and the compounds arabinogalactan and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and kidney, and related mouse phenotypes are tumorigenesis and vision/eye.

Disease Ontology:8 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. it is a serious illnesses in people with a weakened immune system.

MedlinePlus:33 Aspergillosis is a disease caused by a fungus (or mold) called aspergillus. the fungus is very common in both indoors and outdoors. most people breathe in the spores of the fungus every day without being affected. but some people get the disease. it usually occurs in people with lung diseases or weakened immune systems. there are different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa). symptoms of abpa include wheezing and coughing. abpa can affect healthy people but it is most common in people with asthma or cystic fibrosis. another kind is invasive aspergillosis, which damages tissues in the body. it usually affects the lungs. sometimes it can also cause infection in other organs and spread throughout the body. it affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, and an examination of tissues for signs of the fungus. treatment is with antifungal drugs. if you have abpa, you may also take steroids. centers for disease control and prevention

CDC:3 Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus. The types of health problems caused by Aspergillus include allergic reactions, lung infections, and infections in other organs.

Wikipedia:65 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Description from OMIM:46 614079

Aliases & Classifications for Aspergillosis

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 62UMLS, 9diseasecard, 39NCIt, 57SNOMED-CT, 27ICD9CM, 34MeSH, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Aspergillosis, Aliases & Descriptions:

Name: Aspergillosis 8 42 46 10 44 48 33 62
Infection Due to Aspergillus 8 62
 
Aspergillosis, Susceptibility to 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
aspergillosis:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:13564
NCIt39 C2886
ICD9CM27 117.3
MeSH34 D001228
OMIM46 614079
MESH via Orphanet35 D001228
ICD10 via Orphanet26 B44.0, B44.1, B44.2 B44.7, B44.8, B44.9, more
UMLS via Orphanet63 C0004030
ICD1025 B44, B44.9

Related Diseases for Aspergillosis

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Diseases related to Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 247)
idRelated DiseaseScoreTop Affiliating Genes
1invasive aspergillosis32.2TLR2, TLR4
2allergic bronchopulmonary aspergillosis31.4SFTPD, MBL2, IL4, CFTR, IL5
3asthma31.3IL5, IL4
4cystic fibrosis31.3SFTPD, CFTR, TLR4, MBL2
5sinusitis31.2IL5, CFTR
6candidiasis31.0IFNG
7thyroiditis30.7MBL2
8chronic obstructive pulmonary disease30.6CFTR, SFTPD, TLR2
9bronchiectasis30.6TLR2, CFTR, MBL2
10rhinitis30.5IL4, IL5
11respiratory failure30.5CFTR, SFTPD
12leprosy30.4TLR2
13allergic rhinitis30.3IL4, IL5
14meningitis30.3TLR2, MBL2
15influenza30.2IFNG, MBL2, SFTPD, CFTR
16bronchiolitis30.1IL5, TLR4
17mastitis30.1TLR4, TLR2
18common variable immunodeficiency30.1MBL2, IL4
19pneumonia30.1MBL2, IL5, TLR2, SFTPD, CFTR, TLR4
20bronchitis30.1IL5, CFTR
21atopic dermatitis30.0IL4, TLR2
22pulmonary tuberculosis30.0TLR2, MBL2, IL4, IFNG
23sepsis30.0MBL2, TLR2, TLR4, SFTPD
24septic shock30.0TLR4, TLR2, MBL2
25pulmonary eosinophilia29.9IL4, SFTPD, IL5
26leukemia29.8MBL2, IL4, IFNG, CFTR, TLR4, TLR2
27autosomal dominant hyper ige syndrome29.8IL4, IFNG
28graft versus host disease29.8IFNG, IL4
29eosinophilia29.8IL4, IL5, MBL2, IFNG
30dermatitis29.8IL4, IFNG, IL5
31hepatitis c29.6TLR4, IFNG, TLR2
32leishmaniasis29.6IL5, IL4, IFNG
33cutaneous t cell lymphoma29.5IFNG, IL4, IL5
34systemic lupus erythematosus29.5IL4, IFNG, TLR4, TLR2, MBL2
35arthritis29.5TLR2, TLR4, IFNG, IL4
36atopy29.4TLR2, IL4, IL5, TLR4, IFNG
37psoriasis29.4IL5, IL4, IFNG, TLR2
38tuberculosis29.4TLR2, IL4, IFNG, SFTPD, CLEC7A, TLR4
39colitis29.3TLR4, IFNG, TLR2, IL4
40ulcerative colitis28.9TLR2, IL4, IFNG, TLR4, CFTR
41rheumatoid arthritis28.7IFNG, TLR4, SFTPD, CFTR, TLR2, IL4
42hematopoietic stem cell transplantation10.5
43coccidioidomycosis10.5CLEC7A
44chronic granulomatous disease10.5
45rheumatic fever10.5MBL2
46cryptosporidiosis10.5MBL2
47cerebritis10.5
48zygomycosis10.5
49eosinophilic fasciitis10.5IL5
50kimura disease10.5IL5

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to aspergillosis

Symptoms for Aspergillosis

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Clinical features from OMIM:

614079

Drugs & Therapeutics for Aspergillosis

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Drug clinical trials:

Search ClinicalTrials for Aspergillosis

Search NIH Clinical Center for Aspergillosis

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Aspergillosis

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Anatomical Context for Aspergillosis

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MalaCards organs/tissues related to Aspergillosis:

32
Lung, Brain, Kidney, Testes, Bone, Colon, Heart, Skin, Eye, Liver, Myeloid, T cells, Bone marrow, Neutrophil, Whole blood, Thyroid, B cells, Breast, Prostate, Endothelial, Pituitary

Animal Models for Aspergillosis or affiliated genes

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Publications for Aspergillosis

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Articles related to Aspergillosis:

(show top 50)    (show all 1509)
idTitleAuthorsYear
1
PCR in diagnosis of invasive aspergillosis: a meta-analysis of diagnostic performance. (25122854)
2014
2
Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. (24476432)
2014
3
Evaluation of the Aspergillus Western Blot IgG kit for the diagnosis of chronic aspergillosis. (25392351)
2014
4
Sinobronchial allergic aspergillosis with allergic bronchopulmonary aspergillosis: a less common co-existence. (25371437)
2014
5
Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome. (24859554)
2014
6
Serum Galactomannan-Based Early Detection of Invasive Aspergillosis in Hematology Patients Receiving Effective Antimold Prophylaxis. (25165088)
2014
7
Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing aspergillosis. (23616459)
2013
8
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
9
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
10
A case series of chronic necrotizing pulmonary aspergillosis and a new proposal. (23883842)
2013
11
Recurrent pulmonary aspergillosis and mycobacterial infection in an unsplenectomized patient with type 1 Gaucher disease. (24195576)
2013
12
Allergic bronchopulmonary aspergillosis. (22640845)
2012
13
Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples. (22650156)
2012
14
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
15
Clinical features of allergic bronchopulmonary aspergillosis in Korea. (22950037)
2012
16
Poststernotomy aspergillosis: successful treatment with voriconazole, surgical debridement and vacuum-assisted closure therapy. (22473415)
2012
17
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
18
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
19
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
20
A pulmonary aspergillosis case with fatal course in a patient with SIRS clinic. (22091235)
2011
21
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis among asthma patients in eastern India. (21661466)
2010
22
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
23
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
24
Adherence to international guidelines for the treatment of invasive aspergillosis in acute myeloid leukaemia: feasibility and utility (SEIFEM-2008B study). (20639313)
2010
25
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
26
Voriconazole in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis. (19284017)
2009
27
Chronic necrotizing and allergic bronchopulmonary aspergillosis in an asthmatic patient--a therapeutic challenge. (20298342)
2008
28
Successful management of invasive pulmonary nocardiosis and aspergillosis in a patient with T-cell lymphoma: a case report. (24179349)
2008
29
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
30
Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. (17329558)
2007
31
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
32
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
33
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
34
Case quiz. Thoracic CT illustrating hyperdense bronchial mucous plugging: allergic bronchopulmonary aspergillosis. (12890264)
2003
35
Antifungal therapy for allergic bronchopulmonary aspergillosis. (12743553)
2003
36
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
37
Accuracy of CT in the diagnosis of allergic bronchopulmonary aspergillosis in asthmatic patients. (10511153)
1999
38
The role of bronchial biopsy and washing in the diagnosis of allergic bronchopulmonary aspergillosis. (9688180)
1998
39
Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis. (8769507)
1996
40
Immunohistochemical detection of GM-CSF, IL-4 and IL-5 in a murine model of allergic bronchopulmonary aspergillosis. (8732244)
1996
41
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
42
Problems with skin testing in patients with allergic bronchopulmonary aspergillosis. (8603286)
1995
43
Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression. (7663787)
1995
44
Management of allergic bronchopulmonary aspergillosis. (8029520)
1994
45
Pneumothorax and bronchopleural fistula during treatment of allergic bronchopulmonary aspergillosis. (8367756)
1993
46
Concanavalin A-nonbinding Aspergillus fumigatus antigen: a major immunogen in allergic bronchopulmonary aspergillosis. (1583388)
1992
47
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. (1653680)
1991
48
Pathologic features of allergic bronchopulmonary aspergillosis. (3344888)
1988
49
Concomitant pulmonary aspergillosis and nocardiosis in a patient with chronic granulomatous disease of childhood. (6701605)
1984
50
Chronic eosinophilic pneumonia, a manifestation of allergic aspergillosis. (4209914)
1974

Variations for Aspergillosis

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Clinvar genetic disease variations for Aspergillosis:

6
id Gene Name Type Significance SNP ID Assembly Location
1CLEC7ANM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter)single nucleotide variantPathogenicrs16910526GRCh37Chr 12, 10271087: 10271087

Expression for genes affiliated with Aspergillosis

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Expression patterns in normal tissues for genes affiliated with Aspergillosis

Search GEO for disease gene expression data for Aspergillosis.

Pathways for genes affiliated with Aspergillosis

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Pathways related to Aspergillosis according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, TLR4
2
Show member pathways
9.5TLR4, CFTR
3
Show member pathways
9.4CFTR, TLR2
49.4IL4, IL5
59.4IL5, IL4
69.2TLR2, TLR4, CLEC7A
7
Show member pathways
9.1TLR2, IL5, TLR4
8
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.0IL4, IFNG
98.9IL4, TLR2, TLR4
108.9IL5, IL4, TLR2
118.7TLR4, TLR2, IFNG
12
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
8.7TLR2, TLR4, IFNG
138.7TLR2, TLR4, IFNG
148.7IFNG, TLR4, TLR2
158.7TLR4, TLR2, IFNG
168.7TLR2, IFNG, TLR4
17
Show member pathways
IL27-mediated signaling events37
8.7TLR2, IFNG, TLR4
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways60
Immune response IL 1 signaling pathway60
8.7TLR4, CFTR, CLEC7A, TLR2
198.6TLR4, IL4, IFNG
208.6IFNG, IL5, IL4
218.6IFNG, IL5, IL4
228.6IFNG, IL5, IL4
23
Show member pathways
8.6IL5, IL4, IFNG
248.6IFNG, IL4, IL5
258.6IFNG, IL4, IL5
26
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
8.6IL4, IFNG, IL5
27
Show member pathways
Type III interferon signaling37
8.6IL4, IL5, IFNG
28
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.6IL5, IL4, IFNG
298.5SFTPD, TLR4, TLR2, MBL2, CLEC7A
30
Show member pathways
8.5TLR2, TLR4, IL5, IL4
318.4IFNG, TLR2, CLEC7A, TLR4
32
Show member pathways
8.2TLR4, IFNG, IL4, IL5
33
Show member pathways
8.1TLR2, IL4, IFNG, TLR4
34
Show member pathways
8.1IL4, IFNG, TLR2, TLR4
35
Show member pathways
8.1TLR2, TLR4, IFNG, IL4
36
Show member pathways
7.6IL5, IL4, IFNG, TLR4, TLR2
37
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
7.2TLR2, CFTR, IFNG, IL4, TLR4, SFTPD

Compounds for genes affiliated with Aspergillosis

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Compounds related to Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1arabinogalactan449.7TLR4, TLR2
2loteprednol44 1110.6IL4, IL5
3tolnaftate449.6IL5, IL4
4lipoteichoic acid449.5TLR2, TLR4, MBL2
5zymosan449.3TLR2, TLR4, CLEC7A, MBL2
6mannan449.2MBL2, SFTPD, TLR4, TLR2
7peptidoglycan44 2810.2TLR2, TLR4, MBL2
8agarose449.2SFTPD, TLR4, TLR2, MBL2
9carbohydrates449.2SFTPD, MBL2, CFTR, TLR4
10glatiramer acetate44 119.9IL4, IL5, IFNG
11il-12448.9IL5, IL4, IFNG
12mannose448.9CLEC7A, MBL2, TLR4, TLR2, SFTPD
13gm-csf44 289.9IFNG, IL4, IL5
14fluticasone propionate44 50 61 1111.9IL4, IFNG, IL5
15prednisolone44 28 1110.8SFTPD, IFNG, MBL2, IL5
16rolipram44 61 2810.8IL4, IFNG, IL5
17methylcellulose448.8IL4, IL5, IFNG
18polysaccharide448.8TLR2, TLR4, SFTPD, MBL2
19infliximab44 50 1110.8TLR4, IFNG, IL4
20endotoxin448.7TLR2, TLR4, SFTPD, IFNG
21tarc448.7IFNG, IL4, IL5
22imiquimod44 61 28 1111.7IL5, IFNG, TLR2, TLR4
23budesonide44 50 1110.6SFTPD, IL5, IFNG, IL4
24con a448.6MBL2, IL5, IFNG, IL4
25vitamin d448.6TLR2, TLR4, IL5, MBL2, CFTR
26amphotericin b448.5IL4, IFNG, TLR2, IL5
27simvastatin44 50 61 28 24 1113.4IL4, IFNG, TLR2, TLR4
28calcitriol44 61 24 1111.4IFNG, IL4, TLR4, TLR2
29ionomycin448.4IFNG, TLR2, IL4, IL5
30indomethacin44 28 61 1111.3IFNG, IL5, CFTR, IL4
31ivig448.3IL4, IL5, IFNG
32allergens448.3SFTPD, IFNG, IL5, IL4, TLR4
33polymyxin b448.2IL4, TLR2, TLR4, IFNG, MBL2
34polyinosinic-polycytidylic acid448.1TLR4, IFNG, IL5, IL4, TLR2
35poly(i-c)448.1TLR2, IL5, IL4, IFNG, TLR4
36il 10448.1IFNG, TLR2, TLR4, IL4, IL5
37tacrolimus44 50 1110.0IL4, TLR2, IL5, IFNG, TLR4
38sb 20358044 619.0IL4, TLR4, TLR2, IL5, IFNG
39nitric oxide44 24 1110.0MBL2, TLR4, IFNG, SFTPD, TLR2
40anti-fungal448.0IL5, MBL2, SFTPD, TLR4, TLR2, IFNG
41cycloheximide448.0IL5, TLR2, TLR4, IFNG, IL4
42actinomycin d448.0IL4, IFNG, CFTR, TLR4, TLR2
43serine447.7MBL2, SFTPD, IL5, CFTR, TLR4, TLR2
44histamine44 28 249.7IL5, IL4, SFTPD, TLR2, TLR4, IFNG
45rantes447.7MBL2, IL5, IL4, IFNG, TLR4, TLR2
46vegf447.7MBL2, IL5, IL4, IFNG, TLR4, TLR2
47cyclosporin a44 28 619.5IL4, TLR2, TLR4, CFTR, IFNG, IL5
48pge2447.5IFNG, TLR2, TLR4, CFTR, IL4, IL5
49cysteine446.8IFNG, TLR4, TLR2, SFTPD, CFTR, IL4
50dexamethasone44 50 28 119.5TLR4, IL4, IL5, MBL2, CLEC7A, CFTR

GO Terms for genes affiliated with Aspergillosis

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Cellular components related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:0055819.8SFTPD, MBL2
2cell surfaceGO:0099868.8MBL2, CFTR, TLR2
3external side of plasma membraneGO:0098977.8IL4, TLR4, CLEC7A, IFNG, TLR2
4extracellular spaceGO:0056157.8IFNG, IL4, IL5, MBL2, SFTPD

Biological processes related to Aspergillosis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:00275210.0CLEC7A, TLR2
2cellular response to lipoteichoic acidGO:0712239.9TLR2, TLR4
3positive regulation of macrophage cytokine productionGO:0609079.9TLR2, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9TLR4, TLR2
5positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.9TLR2, TLR4
6I-kappaB phosphorylationGO:0072529.8TLR2, TLR4
7positive regulation of chemokine productionGO:0327229.8TLR4, TLR2
8positive regulation of phagocytosisGO:0507669.8SFTPD, CLEC7A, MBL2
9positive regulation of NF-kappaB import into nucleusGO:0423469.8TLR2, TLR4
10positive regulation of interleukin-8 productionGO:0327579.8TLR4, TLR2
11respiratory gaseous exchangeGO:0075859.8CFTR, SFTPD
12positive regulation of interferon-beta productionGO:0327289.8TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:0316639.7TLR2, TLR4
14defense response to Gram-positive bacteriumGO:0508309.7MBL2, TLR2
15negative regulation of osteoclast differentiationGO:0456719.7TLR4, IL4
16positive regulation of interleukin-12 biosynthetic processGO:0450849.6TLR4, IFNG
17positive regulation of interleukin-6 productionGO:0327559.5TLR4, TLR2
18positive regulation of isotype switching to IgG isotypesGO:0483049.4IL4, IFNG
19positive regulation of B cell proliferationGO:0308909.4TLR4, IL4, IL5
20positive regulation of chemokine biosynthetic processGO:0450809.4IL4, IFNG
21response to cytokineGO:0340979.3IL4, CFTR
22positive regulation of interleukin-10 productionGO:0327339.3IL4, TLR4, TLR2
23positive regulation of inflammatory responseGO:0507299.2TLR4, TLR2
24inflammatory responseGO:0069549.2IL5, CLEC7A, TLR2
25negative regulation of growth of symbiont in hostGO:0441309.2TLR2, IFNG, MBL2
26negative regulation of interleukin-17 productionGO:0327009.1IFNG, TLR4, TLR2
27defense response to protozoanGO:0428329.1IL4, IFNG, CLEC7A
28positive regulation of interleukin-12 productionGO:0327359.1IFNG, TLR4, TLR2
29positive regulation of nitric oxide biosynthetic processGO:0454299.1IFNG, TLR4, TLR2
30positive regulation of MHC class II biosynthetic processGO:0453489.0TLR4, IFNG, IL4
31positive regulation of T cell proliferationGO:0421028.9IFNG, IL4
32defense response to bacteriumGO:0427428.9TLR4, SFTPD, IFNG, MBL2
33innate immune responseGO:0450878.9TLR2, TLR4, SFTPD, CLEC7A, MBL2
34immune responseGO:0069558.8TLR2, TLR4, IL4, IL5
35positive regulation of tumor necrosis factor productionGO:0327608.8IFNG, CLEC7A, TLR4, TLR2
36response to drugGO:0424938.6CFTR, IFNG, IL4
37positive regulation of transcription from RNA polymerase II promoterGO:0459448.3TLR2, TLR4, IFNG, IL4

Molecular functions related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.5TLR4, TLR2
2signaling pattern recognition receptor activityGO:0083299.5CLEC7A, TLR2
3cytokine activityGO:0051258.3IFNG, IL4, IL5
4protein bindingGO:0055157.2TLR4, SFTPD, CFTR, IL4, IL5, MBL2

Products for genes affiliated with Aspergillosis

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Sources for Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet