MCID: ASP006
MIFTS: 72

Aspergillosis malady

Rare diseases, Infectious diseases categories

Summaries for Aspergillosis

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9Disease Ontology, 44NIH Rare Diseases, 35MedlinePlus, 4CDC, 66Wikipedia, 48OMIM, 34MalaCards
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NIH Rare Diseases:44 Aspergillosis is an infection, growth, or allergic response caused by the aspergillus fungus. there are several different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. another kind of aspergillosis is invasive aspergillosis. this infection usually affects people with weakened immune systems due to cancer, aids, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. in this condition, the fungus invades and damages tissues in the body. invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. this type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. the fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. last updated: 10/2/2013

MalaCards: Aspergillosis, also known as aspergillosis, susceptibility to, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis. An important gene associated with Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Legionellosis and Cytokine production by Th17 cells in CF. The drugs flucytosine and miconazole and the compounds arabinogalactan and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and kidney, and related mouse phenotypes are tumorigenesis and vision/eye.

Disease Ontology:9 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. it is a serious illnesses in people with a weakened immune system.

MedlinePlus:35 Aspergillosis is a disease caused by a fungus (or mold) called aspergillus. the fungus is very common in both indoors and outdoors. most people breathe in the spores of the fungus every day without being affected. but some people get the disease. it usually occurs in people with lung diseases or weakened immune systems. there are different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa). symptoms of abpa include wheezing and coughing. abpa can affect healthy people but it is most common in people with asthma or cystic fibrosis. another kind is invasive aspergillosis, which damages tissues in the body. it usually affects the lungs. sometimes it can also cause infection in other organs and spread throughout the body. it affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, and an examination of tissues for signs of the fungus. treatment is with antifungal drugs. if you have abpa, you may also take steroids. centers for disease control and prevention

CDC:4 Aspergillus is a common fungus that can be found in indoor and outdoor environments. Most people breathe in Aspergillus spores every day without being affected. Aspergillosis is a disease caused by this fungus and usually occurs in people with lung diseases or weakened immune systems. The spectrum of illness includes allergic reactions, lung infections, and infections in other organs.

Wikipedia:66 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Description from OMIM:48 614079

Aliases & Classifications for Aspergillosis

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9Disease Ontology, 10diseasecard, 44NIH Rare Diseases, 48OMIM, 11DISEASES, 46Novoseek, 50Orphanet, 35MedlinePlus, 63UMLS, 28ICD9CM, 41NCIt, 59SNOMED-CT, 36MeSH, 37MESH via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet, 64UMLS via Orphanet, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

50
aspergillosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

aspergillosis 9 44 48 11 46 50 35 63
aspergillosis, susceptibility to 10
infection due to aspergillus 9
aspergillosis, unspecified 9


External Ids:

Disease Ontology9 DOID:13564
ICD9CM28 117.3
NCIt41 C2886
MeSH36 D001228
OMIM48 614079
MESH via Orphanet37 D001228
SNOMED-CT via Orphanet60 65553006
ICD10 via Orphanet27 B44.0, B44.1, B44.2 B44.7, B44.8, B44.9, more
UMLS via Orphanet64 C0004030
ICD1026 B44, B44.9

Related Diseases for Aspergillosis

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 238)
idRelated DiseaseScoreTop Affiliating Genes
1invasive aspergillosis31.9TLR2, TLR4
2allergic bronchopulmonary aspergillosis31.7SFTPD, MBL2, IL4, CFTR, IL5
3cystic fibrosis31.2SFTPD, CFTR, TLR4, MBL2
4asthma31.0IL5, IL4
5sinusitis30.9IL5, CFTR
6candidiasis30.7IFNG
7leukemia30.6MBL2, IL4, IFNG, CFTR, TLR4, TLR2
8pneumonia30.5MBL2, IL5, TLR2, SFTPD, CFTR, TLR4
9bronchiectasis30.5TLR2, CFTR, MBL2
10influenza30.4IFNG, MBL2, SFTPD, CFTR
11pulmonary tuberculosis30.4TLR2, MBL2, IL4, IFNG
12rhinitis30.3IL4, IL5
13tuberculosis30.3TLR2, IL4, IFNG, SFTPD, CLEC7A, TLR4
14respiratory failure30.2CFTR, SFTPD
15thyroiditis30.1MBL2
16eosinophilia30.1IL4, IL5, MBL2, IFNG
17allergic rhinitis30.0IL4, IL5
18meningitis30.0TLR2, MBL2
19systemic lupus erythematosus30.0IL4, IFNG, TLR4, TLR2, MBL2
20atopy30.0TLR2, IL4, IL5, TLR4, IFNG
21atopic dermatitis30.0IL4, TLR2
22sepsis30.0MBL2, TLR2, TLR4, SFTPD
23graft versus host disease29.9IFNG, IL4
24dermatitis29.9IL4, IFNG, IL5
25arthritis29.9TLR2, TLR4, IFNG, IL4
26psoriasis29.8IL5, IL4, IFNG, TLR2
27bronchiolitis29.8IL5, TLR4
28mastitis29.8TLR4, TLR2
29bronchitis29.8IL5, CFTR
30septic shock29.8TLR4, TLR2, MBL2
31pulmonary eosinophilia29.8IL4, SFTPD, IL5
32autosomal dominant hyper ige syndrome29.8IL4, IFNG
33hepatitis c29.7TLR4, IFNG, TLR2
34leishmaniasis29.7IL5, IL4, IFNG
35cutaneous t cell lymphoma29.7IFNG, IL4, IL5
36rheumatoid arthritis29.7IFNG, TLR4, SFTPD, CFTR, TLR2, IL4
37hematopoietic stem cell transplantation10.5
38chronic granulomatous disease10.5
39zygomycosis10.5
40cerebritis10.5
41acute myeloid leukemia10.3
42myeloid leukemia10.3
43acute leukemia10.3
44neutropenia10.3
45nocardiosis10.3
46hepatitis10.3
47pulmonary aspergilloma10.2
48pneumothorax10.2
49lupus erythematosus10.1
50sarcoidosis10.1

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to aspergillosis

Symptoms for Aspergillosis

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48OMIM
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Clinical features from OMIM:

614079

Drugs & Therapeutics for Aspergillosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Aspergillosis

Search NIH Clinical Center for Aspergillosis

Search CenterWatch for Aspergillosis

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Aspergillosis

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Anatomical Context for Aspergillosis

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34MalaCards
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MalaCards organs/tissues related to Aspergillosis:

34
Lung, Brain, Kidney, Testes, Bone, Colon, Heart, Skin, Eye, Liver, Myeloid, T cells, Bone marrow, B cells, Thyroid, Whole blood, Prostate, Breast, Endothelial, Pituitary

Animal Models for Aspergillosis or affiliated genes

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38MGI
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Publications for Aspergillosis

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53PubMed
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Articles related to Aspergillosis:

(show top 50)    (show all 1453)
idTitleAuthorsYear
1
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
2
Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing aspergillosis. (23616459)
2013
3
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
4
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
5
A case series of chronic necrotizing pulmonary aspergillosis and a new proposal. (23883842)
2013
6
Recurrent pulmonary aspergillosis and mycobacterial infection in an unsplenectomized patient with type 1 Gaucher disease. (24195576)
2013
7
Fluid rim sign: a new ultrasonographic sign of soft tissue aspergillosis. (23233408)
2013
8
Allergic bronchopulmonary aspergillosis. (22640845)
2012
9
Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples. (22650156)
2012
10
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
11
Clinical features of allergic bronchopulmonary aspergillosis in Korea. (22950037)
2012
12
Poststernotomy aspergillosis: successful treatment with voriconazole, surgical debridement and vacuum-assisted closure therapy. (22473415)
2012
13
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
14
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
15
The role of combination antifungal therapy in the treatment of invasive aspergillosis: a systematic review. (22137271)
2012
16
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
17
A pulmonary aspergillosis case with fatal course in a patient with SIRS clinic. (22091235)
2011
18
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis among asthma patients in eastern India. (21661466)
2010
19
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
20
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
21
Adherence to international guidelines for the treatment of invasive aspergillosis in acute myeloid leukaemia: feasibility and utility (SEIFEM-2008B study). (20639313)
2010
22
Allergic bronchopulmonary aspergillosis: Indian perspective. (19445441)
2009
23
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
24
Voriconazole in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis. (19284017)
2009
25
Successful management of invasive pulmonary nocardiosis and aspergillosis in a patient with T-cell lymphoma: a case report. (24179349)
2008
26
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
27
Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. (17329558)
2007
28
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
29
Images in HIV/AIDS. Invasive aspergillosis presenting as a neck mass in a person with HIV/AIDS. (17672013)
2007
30
Is combination antifungal therapy for invasive aspergillosis a necessity in hematopoietic stem-cell transplant recipients? (16804386)
2006
31
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
32
Concurrent sino-orbital aspergillosis and cerebral nocardiosis. (15179067)
2004
33
Case quiz. Thoracic CT illustrating hyperdense bronchial mucous plugging: allergic bronchopulmonary aspergillosis. (12890264)
2003
34
Antifungal therapy for allergic bronchopulmonary aspergillosis. (12743553)
2003
35
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
36
Accuracy of CT in the diagnosis of allergic bronchopulmonary aspergillosis in asthmatic patients. (10511153)
1999
37
The role of bronchial biopsy and washing in the diagnosis of allergic bronchopulmonary aspergillosis. (9688180)
1998
38
Recurrence of allergic bronchopulmonary aspergillosis in the posttransplant lungs of a cystic fibrosis patient. (9228393)
1997
39
Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis. (8769507)
1996
40
Immunohistochemical detection of GM-CSF, IL-4 and IL-5 in a murine model of allergic bronchopulmonary aspergillosis. (8732244)
1996
41
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
42
Problems with skin testing in patients with allergic bronchopulmonary aspergillosis. (8603286)
1995
43
Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression. (7663787)
1995
44
Management of allergic bronchopulmonary aspergillosis. (8029520)
1994
45
Pneumothorax and bronchopleural fistula during treatment of allergic bronchopulmonary aspergillosis. (8367756)
1993
46
Concanavalin A-nonbinding Aspergillus fumigatus antigen: a major immunogen in allergic bronchopulmonary aspergillosis. (1583388)
1992
47
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. (1653680)
1991
48
Pathologic features of allergic bronchopulmonary aspergillosis. (3344888)
1988
49
Concomitant pulmonary aspergillosis and nocardiosis in a patient with chronic granulomatous disease of childhood. (6701605)
1984
50
Chronic eosinophilic pneumonia, a manifestation of allergic aspergillosis. (4209914)
1974

Variations for Aspergillosis

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1 National Center for Biotechnology Information (Clinvar)
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Clinvar genetic disease variations for Aspergillosis:

1
id Gene Name Type Significance SNP ID Assembly Location
1CLEC7ANM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter)single nucleotide variantPathogenic, risk factorrs16910526GRCh37Chr 12, 10271087: 10271087

Expression for genes affiliated with Aspergillosis

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aspergillosis

Search GEO for disease gene expression data for Aspergillosis.

Pathways for genes affiliated with Aspergillosis

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Sources:
51PathCards, 31KEGG, 61Thomson Reuters, 56Reactome, 55R&D Systems, 39NCBI BioSystems Database, 5Cell Signaling Technology, 62Tocris Bioscience, 13EMD Millipore, 54QIAGEN
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Pathways related to Aspergillosis according to GeneCards/GeneDecks:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR4, TLR2
2
Show member pathways
9.5TLR4, CFTR
3
Show member pathways
9.4CFTR, TLR2
49.4IL5, IL4
59.4IL5, IL4
69.2CLEC7A, TLR4, TLR2
7
Show member pathways
9.1TLR2, TLR4, IL5
8
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.0IL4, IFNG
98.9IL4, TLR4, TLR2
108.9IL5, IL4, TLR2
118.7IFNG, TLR4, TLR2
12
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
8.7TLR2, TLR4, IFNG
138.7TLR2, TLR4, IFNG
148.7TLR2, TLR4, IFNG
15
Show member pathways
IL27-mediated signaling events39
8.7TLR2, TLR4, IFNG
168.7IFNG, TLR4, TLR2
178.7TLR2, TLR4, IFNG
18
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways61
Immune response IL 1 signaling pathway61
8.7TLR2, TLR4, CFTR, CLEC7A
198.6IL4, IFNG, TLR4
208.6IFNG, IL4, IL5
21
Show member pathways
8.6IL5, IL4, IFNG
228.6IL5, IL4, IFNG
23
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
8.6IL5, IL4, IFNG
24
Show member pathways
Type III interferon signaling39
8.6IL5, IL4, IFNG
258.6IL5, IL4, IFNG
268.6IL5, IL4, IFNG
278.6IL5, IL4, IFNG
28
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.6IFNG, IL4, IL5
298.5TLR2, TLR4, SFTPD, CLEC7A, MBL2
30
Show member pathways
8.5TLR2, TLR4, IL4, IL5
318.4TLR2, TLR4, CLEC7A, IFNG
32
Show member pathways
8.2TLR4, IFNG, IL4, IL5
33
Show member pathways
8.1TLR2, TLR4, IFNG, IL4
34
Show member pathways
8.1TLR2, TLR4, IFNG, IL4
35
Show member pathways
8.1IL4, IFNG, TLR4, TLR2
36
Show member pathways
7.6TLR2, TLR4, IFNG, IL4, IL5
37
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
7.2IL4, IFNG, CFTR, SFTPD, TLR4, TLR2

Compounds for genes affiliated with Aspergillosis

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Sources:
46Novoseek, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience, 25HMDB
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Compounds related to Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1arabinogalactan469.7TLR4, TLR2
2loteprednol46 1210.6IL4, IL5
3tolnaftate469.6IL5, IL4
4lipoteichoic acid469.5TLR2, TLR4, MBL2
5zymosan469.3TLR2, TLR4, CLEC7A, MBL2
6mannan469.2MBL2, SFTPD, TLR4, TLR2
7peptidoglycan46 3010.2TLR2, TLR4, MBL2
8agarose469.2SFTPD, TLR4, TLR2, MBL2
9carbohydrates469.2SFTPD, MBL2, CFTR, TLR4
10glatiramer acetate46 129.9IL4, IL5, IFNG
11il-12468.9IL5, IL4, IFNG
12mannose468.9CLEC7A, MBL2, TLR4, TLR2, SFTPD
13gm-csf46 309.9IFNG, IL4, IL5
14fluticasone propionate46 52 62 1211.9IL4, IFNG, IL5
15prednisolone46 30 1210.8SFTPD, IFNG, MBL2, IL5
16rolipram46 62 3010.8IL4, IFNG, IL5
17methylcellulose468.8IL4, IL5, IFNG
18polysaccharide468.8TLR2, TLR4, SFTPD, MBL2
19infliximab46 52 1210.8TLR4, IFNG, IL4
20endotoxin468.7TLR2, TLR4, SFTPD, IFNG
21tarc468.7IFNG, IL4, IL5
22imiquimod46 62 30 1211.7IL5, IFNG, TLR2, TLR4
23budesonide46 52 1210.6SFTPD, IL5, IFNG, IL4
24con a468.6MBL2, IL5, IFNG, IL4
25vitamin d468.6TLR2, TLR4, IL5, MBL2, CFTR
26amphotericin b468.5IL4, IFNG, TLR2, IL5
27simvastatin46 52 62 30 25 1213.4IL4, IFNG, TLR2, TLR4
28calcitriol46 62 25 1211.4IFNG, IL4, TLR4, TLR2
29ionomycin468.4IFNG, TLR2, IL4, IL5
30indomethacin46 30 62 1211.3IFNG, IL5, CFTR, IL4
31ivig468.3IL4, IL5, IFNG
32allergens468.3SFTPD, IFNG, IL5, IL4, TLR4
33polymyxin b468.2IL4, TLR2, TLR4, IFNG, MBL2
34polyinosinic-polycytidylic acid468.1TLR4, IFNG, IL5, IL4, TLR2
35poly(i-c)468.1TLR2, IL5, IL4, IFNG, TLR4
36il 10468.1IFNG, TLR2, TLR4, IL4, IL5
37tacrolimus46 52 1210.0IL4, TLR2, IL5, IFNG, TLR4
38sb 20358046 629.0IL4, TLR4, TLR2, IL5, IFNG
39nitric oxide46 25 1210.0MBL2, TLR4, IFNG, SFTPD, TLR2
40anti-fungal468.0IL5, MBL2, SFTPD, TLR4, TLR2, IFNG
41cycloheximide468.0IL5, TLR2, TLR4, IFNG, IL4
42actinomycin d468.0IL4, IFNG, CFTR, TLR4, TLR2
43serine467.7MBL2, SFTPD, IL5, CFTR, TLR4, TLR2
44histamine46 30 259.7IL5, IL4, SFTPD, TLR2, TLR4, IFNG
45rantes467.7MBL2, IL5, IL4, IFNG, TLR4, TLR2
46vegf467.7MBL2, IL5, IL4, IFNG, TLR4, TLR2
47cyclosporin a46 30 629.5IL4, TLR2, TLR4, CFTR, IFNG, IL5
48pge2467.5IFNG, TLR2, TLR4, CFTR, IL4, IL5
49cysteine466.8IFNG, TLR4, TLR2, SFTPD, CFTR, IL4
50dexamethasone46 52 30 129.5TLR4, IL4, IL5, MBL2, CLEC7A, CFTR

GO Terms for genes affiliated with Aspergillosis

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17Gene Ontology
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Cellular components related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:0055819.8MBL2, SFTPD
2cell surfaceGO:0099868.8MBL2, CFTR, TLR2
3external side of plasma membraneGO:0098977.8IL4, IFNG, CLEC7A, TLR4, TLR2
4extracellular spaceGO:0056157.8SFTPD, IFNG, IL4, IL5, MBL2

Biological processes related to Aspergillosis according to GeneCards/GeneDecks:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:00275210.0CLEC7A, TLR2
2cellular response to lipoteichoic acidGO:0712239.9TLR2, TLR4
3positive regulation of macrophage cytokine productionGO:0609079.9TLR2, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:0425359.9TLR4, TLR2
5positive regulation of nitric-oxide synthase biosynthetic processGO:0517709.9TLR2, TLR4
6I-kappaB phosphorylationGO:0072529.8TLR2, TLR4
7positive regulation of chemokine productionGO:0327229.8TLR4, TLR2
8positive regulation of phagocytosisGO:0507669.8SFTPD, CLEC7A, MBL2
9positive regulation of NF-kappaB import into nucleusGO:0423469.8TLR2, TLR4
10positive regulation of interleukin-8 productionGO:0327579.8TLR4, TLR2
11respiratory gaseous exchangeGO:0075859.8CFTR, SFTPD
12positive regulation of interferon-beta productionGO:0327289.8TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:0316639.7TLR2, TLR4
14defense response to Gram-positive bacteriumGO:0508309.7MBL2, TLR2
15negative regulation of osteoclast differentiationGO:0456719.7TLR4, IL4
16positive regulation of interleukin-12 biosynthetic processGO:0450849.6TLR4, IFNG
17positive regulation of interleukin-6 productionGO:0327559.5TLR4, TLR2
18positive regulation of isotype switching to IgG isotypesGO:0483049.4IL4, IFNG
19positive regulation of B cell proliferationGO:0308909.4TLR4, IL4, IL5
20positive regulation of chemokine biosynthetic processGO:0450809.4IL4, IFNG
21response to cytokineGO:0340979.3IL4, CFTR
22positive regulation of interleukin-10 productionGO:0327339.3IL4, TLR4, TLR2
23positive regulation of inflammatory responseGO:0507299.2TLR4, TLR2
24inflammatory responseGO:0069549.2IL5, CLEC7A, TLR2
25negative regulation of growth of symbiont in hostGO:0441309.2TLR2, IFNG, MBL2
26negative regulation of interleukin-17 productionGO:0327009.1IFNG, TLR4, TLR2
27defense response to protozoanGO:0428329.1IL4, IFNG, CLEC7A
28positive regulation of interleukin-12 productionGO:0327359.1IFNG, TLR4, TLR2
29positive regulation of nitric oxide biosynthetic processGO:0454299.1IFNG, TLR4, TLR2
30positive regulation of MHC class II biosynthetic processGO:0453489.0TLR4, IFNG, IL4
31positive regulation of T cell proliferationGO:0421028.9IFNG, IL4
32defense response to bacteriumGO:0427428.9TLR4, SFTPD, IFNG, MBL2
33innate immune responseGO:0450878.9TLR2, TLR4, SFTPD, CLEC7A, MBL2
34immune responseGO:0069558.8TLR2, TLR4, IL4, IL5
35positive regulation of tumor necrosis factor productionGO:0327608.8IFNG, CLEC7A, TLR4, TLR2
36response to drugGO:0424938.6CFTR, IFNG, IL4
37positive regulation of transcription from RNA polymerase II promoterGO:0459448.3TLR2, TLR4, IFNG, IL4

Molecular functions related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:0018759.5TLR4, TLR2
2signaling pattern recognition receptor activityGO:0083299.5CLEC7A, TLR2
3cytokine activityGO:0051258.3IFNG, IL4, IL5
4protein bindingGO:0055157.2TLR4, SFTPD, CFTR, IL4, IL5, MBL2

Products for genes affiliated with Aspergillosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aspergillosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet