MCID: ASP006
MIFTS: 63

Aspergillosis malady

Genetic diseases, Rare diseases, Infectious diseases categories

Summaries for Aspergillosis

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NIH Rare Diseases:41 Aspergillosis is an infection, growth, or allergic response caused by the aspergillus fungus. there are several different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. another kind of aspergillosis is invasive aspergillosis. this infection usually affects people with weakened immune systems due to cancer, aids, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. in this condition, the fungus invades and damages tissues in the body. invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. this type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. the fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. last updated: 10/2/2013

MalaCards based summary: Aspergillosis, also known as aspergillosis, susceptibility to, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis. An important gene associated with Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Legionellosis and Cytokine production by Th17 cells in CF. The drugs flucytosine and miconazole and the compounds arabinogalactan and loteprednol have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and brain, and related mouse phenotypes are tumorigenesis and vision/eye.

Disease Ontology:9 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. it is a serious illnesses in people with a weakened immune system.

MedlinePlus:32 Aspergillosis is a disease caused by a fungus (or mold) called aspergillus. the fungus is very common in both indoors and outdoors. most people breathe in the spores of the fungus every day without being affected. but some people get the disease. it usually occurs in people with lung diseases or weakened immune systems. there are different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa). symptoms of abpa include wheezing and coughing. abpa can affect healthy people but it is most common in people with asthma or cystic fibrosis. another kind is invasive aspergillosis, which damages tissues in the body. it usually affects the lungs. sometimes it can also cause infection in other organs and spread throughout the body. it affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, and an examination of tissues for signs of the fungus. treatment is with antifungal drugs. if you have abpa, you may also take steroids. centers for disease control and prevention

CDC:3 Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus. The types of health problems caused by Aspergillus include allergic reactions, lung infections, and infections in other organs.

OMIM:45 Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization... (614079) more...

Wikipedia:63 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Aliases & Classifications for Aspergillosis

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Sources:
45OMIM, 9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 32MedlinePlus, 3CDC, 60UMLS, 10diseasecard, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 34MESH via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
See all sources

Aspergillosis, Aliases & Descriptions:

Name: Aspergillosis 45 9 41 11 43 47 32 3 60
Aspergillosis, Susceptibility to 10
 
Infection Due to Aspergillus 9


Classifications:



Characteristics (Orphanet epidemiological data):

47
aspergillosis:
Inheritance: Not applicable; Age of onset: All ages


External Ids:

OMIM45 614079
Disease Ontology9 DOID:13564
ICD9CM27 117.3
MeSH33 D001228
NCIt38 C2886
Orphanet47 1163
MESH via Orphanet34 D001228
ICD10 via Orphanet26 B44.0, B44.1, B44.2 B44.7, B44.8, B44.9, more
UMLS via Orphanet61 C0004030
ICD1025 B44, B44.9

Related Diseases for Aspergillosis

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Diseases related to Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 243)
idRelated DiseaseScoreTop Affiliating Genes
1invasive aspergillosis32.2TLR2, TLR4
2allergic bronchopulmonary aspergillosis31.4SFTPD, MBL2, IL4, CFTR, IL5
3asthma31.3IL5, IL4
4cystic fibrosis31.3SFTPD, CFTR, TLR4, MBL2
5sinusitis31.2IL5, CFTR
6candidiasis31.0IFNG
7thyroiditis30.8MBL2
8bronchiectasis30.5TLR2, CFTR, MBL2
9rhinitis30.4IL4, IL5
10respiratory failure30.4CFTR, SFTPD
11leprosy30.4TLR2
12allergic rhinitis30.3IL4, IL5
13meningitis30.3TLR2, MBL2
14influenza30.2IFNG, MBL2, SFTPD, CFTR
15bronchiolitis30.1IL5, TLR4
16mastitis30.1TLR4, TLR2
17pneumonia30.1MBL2, IL5, TLR2, SFTPD, CFTR, TLR4
18common variable immunodeficiency30.1MBL2, IL4
19bronchitis30.1IL5, CFTR
20atopic dermatitis30.0IL4, TLR2
21pulmonary tuberculosis30.0TLR2, MBL2, IL4, IFNG
22pulmonary eosinophilia29.9IL4, SFTPD, IL5
23leukemia29.8MBL2, IL4, IFNG, CFTR, TLR4, TLR2
24eosinophilia29.8IL4, IL5, MBL2, IFNG
25acute graft versus host disease29.8IL4, IFNG
26dermatitis29.7IL4, IFNG, IL5
27hepatitis c29.6TLR4, IFNG, TLR2
28leishmaniasis29.5IL5, IL4, IFNG
29cutaneous t cell lymphoma29.5IFNG, IL4, IL5
30systemic lupus erythematosus29.5IL4, IFNG, TLR4, TLR2, MBL2
31colitis29.5TLR4, IFNG, TLR2, IL4
32arthritis29.5TLR2, TLR4, IFNG, IL4
33atopy29.4TLR2, IL4, IL5, TLR4, IFNG
34psoriasis29.4IL5, IL4, IFNG, TLR2
35tuberculosis29.4TLR2, IL4, IFNG, SFTPD, CLEC7A, TLR4
36ulcerative colitis28.9TLR2, IL4, IFNG, TLR4, CFTR
37rheumatoid arthritis28.7IFNG, TLR4, SFTPD, CFTR, TLR2, IL4
38hematopoietic stem cell transplantation10.5
39coccidioidomycosis10.5CLEC7A
40chronic granulomatous disease10.5
41cerebritis10.5
42rheumatic fever10.5MBL2
43cryptosporidiosis10.5MBL2
44zygomycosis10.5
45eosinophilic fasciitis10.5IL5
46kimura disease10.5IL5
47eosinophilia-myalgia syndrome10.5IL5
48keratoconjunctivitis10.5IL5
49strongyloidiasis10.4IL5
50keratoconjunctivitis sicca10.4CFTR

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to aspergillosis

Symptoms for Aspergillosis

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Clinical features from OMIM:

614079

Drugs & Therapeutics for Aspergillosis

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Drug clinical trials:

Search ClinicalTrials for Aspergillosis

Search NIH Clinical Center for Aspergillosis

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Aspergillosis

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Anatomical Context for Aspergillosis

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MalaCards organs/tissues related to Aspergillosis:

31
Lung, Kidney, Brain, Testes, Bone, Heart, Colon, Skin, Eye, Liver, Myeloid, T cells, Bone marrow, Neutrophil, Thyroid, B cells, Whole blood, Breast, Prostate, Endothelial, Pituitary

Animal Models for Aspergillosis or affiliated genes

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MGI Mouse Phenotypes related to Aspergillosis:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020068.2IFNG, TLR4, TLR2, IL5
2MP:00053918.1IL4, CFTR, TLR4, IFNG
3MP:00053677.8IL4, MBL2, IFNG, TLR2, TLR4
4MP:00053897.6TLR4, IL4, IFNG, CFTR, IL5
5MP:00053867.4IL5, TLR2, TLR4, CFTR, IFNG
6MP:00053707.3TLR4, IL5, IL4, IFNG, CFTR, TLR2
7MP:00053817.0IL5, TLR2, TLR4, CLEC7A, IFNG, IL4
8MP:00107687.0TLR2, TLR4, IL4, IFNG, CLEC7A, CFTR
9MP:00053786.9IL5, IL4, IFNG, CFTR, TLR4, TLR2
10MP:00053886.7IL5, TLR2, CLEC7A, IFNG, IL4, CFTR
11MP:00053976.3TLR2, MBL2, IL5, IL4, TLR4, IFNG
12MP:00053876.3MBL2, IL5, IL4, IFNG, CLEC7A, TLR4
13MP:00053766.3IL5, MBL2, TLR2, TLR4, CFTR, CLEC7A

Publications for Aspergillosis

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Articles related to Aspergillosis:

(show top 50)    (show all 1553)
idTitleAuthorsYear
1
Genomic analysis for single nucleotide polymorphisms (Asp299Gly and Thr399lle) in Japanese patients with invasive aspergillosis. (25766605)
2015
2
Gastric wall perforation secondary to presumed aspergillosis in a pediatric patient with aplastic anemia: A case report. (25881536)
2015
3
Tumoral presentation of invasive cerebral aspergillosis. (25860478)
2015
4
PCR in diagnosis of invasive aspergillosis: a meta-analysis of diagnostic performance. (25122854)
2014
5
Genetic PTX3 deficiency and aspergillosis in stem-cell transplantation. (24476432)
2014
6
Evaluation of the Aspergillus Western Blot IgG kit for the diagnosis of chronic aspergillosis. (25392351)
2014
7
Sinobronchial allergic aspergillosis with allergic bronchopulmonary aspergillosis: a less common co-existence. (25371437)
2014
8
Invasive pulmonary aspergillosis in a patient presenting with idiopathic systemic capillary leak syndrome. (24859554)
2014
9
Serum Galactomannan-Based Early Detection of Invasive Aspergillosis in Hematology Patients Receiving Effective Antimold Prophylaxis. (25165088)
2014
10
Renal Infarction Secondary to Invasive Aspergillosis in a 5-Year-Old Girl With Acute Lymphoblastic Leukemia. (24136022)
2013
11
Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing aspergillosis. (23616459)
2013
12
Comparison of a novel Aspergillus lateral-flow device and the PlateliaAr galactomannan assay for the diagnosis of invasive aspergillosis following haematopoietic stem cell transplantation. (23661288)
2013
13
TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. (23862689)
2013
14
A case series of chronic necrotizing pulmonary aspergillosis and a new proposal. (23883842)
2013
15
Allergic bronchopulmonary aspergillosis. (22640845)
2012
16
Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples. (22650156)
2012
17
Clinical epidemiology of 960 patients with invasive aspergillosis from the PATH Alliance registry. (22898389)
2012
18
Clinical features of allergic bronchopulmonary aspergillosis in Korea. (22950037)
2012
19
Poststernotomy aspergillosis: successful treatment with voriconazole, surgical debridement and vacuum-assisted closure therapy. (22473415)
2012
20
Invasive aspergillosis: an important risk factor on the short- and long-term survival of acute myeloid leukemia (AML) patients. (21909650)
2012
21
Invasive aspergillosis associated with pulmonary hydatid disease. (22824534)
2012
22
Epidemiology and antifungal resistance in invasive Aspergillosis according to primary disease: review of the literature. (21486729)
2011
23
A pulmonary aspergillosis case with fatal course in a patient with SIRS clinic. (22091235)
2011
24
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis among asthma patients in eastern India. (21661466)
2010
25
Invasive aspergillosis after pandemic (H1N1) 2009. (20507748)
2010
26
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
27
Allergic bronchopulmonary aspergillosis: Indian perspective. (19445441)
2009
28
Risk stratification for invasive aspergillosis: early assessment of host susceptibility. (19253143)
2009
29
Voriconazole in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis. (19284017)
2009
30
Chronic necrotizing and allergic bronchopulmonary aspergillosis in an asthmatic patient--a therapeutic challenge. (20298342)
2008
31
Successful management of invasive pulmonary nocardiosis and aspergillosis in a patient with T-cell lymphoma: a case report. (24179349)
2008
32
Detection of circulating Aspergillus fumigatus DNA by real-time PCR assay of large serum volumes improves early diagnosis of invasive aspergillosis in high-risk adult patients under hematologic surveillance. (18845828)
2008
33
Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti-IgE antibody. (17329558)
2007
34
Aspergillus galactomannan antigen in the bronchoalveolar lavage fluid for the diagnosis of invasive aspergillosis in lung transplant recipients. (17519782)
2007
35
Combination therapy with terbinafine and amphotericin B in a rabbit model of experimental invasive aspergillosis. (16251321)
2005
36
Case quiz. Thoracic CT illustrating hyperdense bronchial mucous plugging: allergic bronchopulmonary aspergillosis. (12890264)
2003
37
Antifungal therapy for allergic bronchopulmonary aspergillosis. (12743553)
2003
38
Allergic bronchopulmonary aspergillosis, allergic fungal sinusitis, and hypersensitivity pneumonitis. (11577554)
2002
39
Accuracy of CT in the diagnosis of allergic bronchopulmonary aspergillosis in asthmatic patients. (10511153)
1999
40
The role of bronchial biopsy and washing in the diagnosis of allergic bronchopulmonary aspergillosis. (9688180)
1998
41
Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis. (8769507)
1996
42
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
43
Problems with skin testing in patients with allergic bronchopulmonary aspergillosis. (8603286)
1995
44
Management of allergic bronchopulmonary aspergillosis. (8029520)
1994
45
Pneumothorax and bronchopleural fistula during treatment of allergic bronchopulmonary aspergillosis. (8367756)
1993
46
Concanavalin A-nonbinding Aspergillus fumigatus antigen: a major immunogen in allergic bronchopulmonary aspergillosis. (1583388)
1992
47
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. (1653680)
1991
48
Pathologic features of allergic bronchopulmonary aspergillosis. (3344888)
1988
49
Concomitant pulmonary aspergillosis and nocardiosis in a patient with chronic granulomatous disease of childhood. (6701605)
1984
50
Chronic eosinophilic pneumonia, a manifestation of allergic aspergillosis. (4209914)
1974

Variations for Aspergillosis

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Clinvar genetic disease variations for Aspergillosis:

6
id Gene Variation Type Significance SNP ID Assembly Location
1CLEC7ANM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter)single nucleotide variantPathogenic, risk factorrs16910526GRCh37Chr 12, 10271087: 10271087

Expression for genes affiliated with Aspergillosis

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Search GEO for disease gene expression data for Aspergillosis.

Pathways for genes affiliated with Aspergillosis

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Pathways related to Aspergillosis according to GeneCards Suite gene sharing:

(show all 37)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.5TLR2, TLR4
2
Show member pathways
9.5TLR4, CFTR
3
Show member pathways
9.4CFTR, TLR2
49.4IL4, IL5
59.4IL5, IL4
69.2TLR2, TLR4, CLEC7A
7
Show member pathways
9.1TLR2, IL5, TLR4
8
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.0IL4, IFNG
98.9IL4, TLR2, TLR4
108.7TLR4, TLR2, IFNG
11
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
8.7TLR2, TLR4, IFNG
128.7TLR2, TLR4, IFNG
138.7IFNG, TLR4, TLR2
148.7TLR4, TLR2, IFNG
158.7TLR2, IFNG, TLR4
16
Show member pathways
IL27-mediated signaling events36
8.7TLR2, IFNG, TLR4
17
Show member pathways
Immune response Role of TLRs 3 and 4 in cell antiviral response TICAM1 specific signaling pathways58
Immune response IL 1 signaling pathway58
8.7TLR4, CFTR, CLEC7A, TLR2
188.6TLR4, IL4, IFNG
198.6IFNG, IL5, IL4
208.6IFNG, IL5, IL4
218.6IFNG, IL5, IL4
22
Show member pathways
8.6IL5, IL4, IFNG
238.6IFNG, IL4, IL5
248.6IFNG, IL4, IL5
25
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
8.6IL4, IFNG, IL5
26
Show member pathways
Type III interferon signaling36
8.6IL4, IL5, IFNG
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.6IL5, IL4, IFNG
288.5SFTPD, TLR4, TLR2, MBL2, CLEC7A
29
Show member pathways
8.5TLR2, TLR4, IL5, IL4
308.4IFNG, TLR2, CLEC7A, TLR4
31
Show member pathways
8.2TLR4, IFNG, IL4, IL5
32
Show member pathways
8.1TLR2, IL4, IFNG, TLR4
33
Show member pathways
8.1IL4, IFNG, TLR2, TLR4
34
Show member pathways
8.1TLR2, TLR4, IFNG, IL4
35
Show member pathways
7.6IL5, IL4, IFNG, TLR4, TLR2
36
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
7.2TLR2, CFTR, IFNG, IL4, TLR4, SFTPD

Compounds for genes affiliated with Aspergillosis

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Compounds related to Aspergillosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 130)
idCompoundScoreTop Affiliating Genes
1arabinogalactan439.7TLR4, TLR2
2loteprednol43 1210.6IL4, IL5
3tolnaftate439.6IL5, IL4
4lipoteichoic acid439.5TLR2, TLR4, MBL2
5zymosan439.3TLR2, TLR4, CLEC7A, MBL2
6mannan439.2MBL2, SFTPD, TLR4, TLR2
7peptidoglycan43 2810.2TLR2, TLR4, MBL2
8agarose439.2SFTPD, TLR4, TLR2, MBL2
9carbohydrates439.2SFTPD, MBL2, CFTR, TLR4
10glatiramer acetate43 129.9IL4, IL5, IFNG
11il-12438.9IL5, IL4, IFNG
12mannose438.9CLEC7A, MBL2, TLR4, TLR2, SFTPD
13gm-csf43 289.9IFNG, IL4, IL5
14fluticasone propionate43 49 59 1211.9IL4, IFNG, IL5
15prednisolone43 28 1210.8SFTPD, IFNG, MBL2, IL5
16rolipram43 59 2810.8IL4, IFNG, IL5
17methylcellulose438.8IL4, IL5, IFNG
18polysaccharide438.8TLR2, TLR4, SFTPD, MBL2
19infliximab43 49 1210.8TLR4, IFNG, IL4
20endotoxin438.7TLR2, TLR4, SFTPD, IFNG
21tarc438.7IFNG, IL4, IL5
22imiquimod43 59 28 1211.7IL5, IFNG, TLR2, TLR4
23budesonide43 49 1210.6SFTPD, IL5, IFNG, IL4
24con a438.6MBL2, IL5, IFNG, IL4
25vitamin d438.6TLR2, TLR4, IL5, MBL2, CFTR
26amphotericin b438.5IL4, IFNG, TLR2, IL5
27simvastatin43 49 59 28 24 1213.4IL4, IFNG, TLR2, TLR4
28calcitriol43 59 24 1211.4IFNG, IL4, TLR4, TLR2
29ionomycin438.4IFNG, TLR2, IL4, IL5
30indomethacin43 28 59 1211.3IFNG, IL5, CFTR, IL4
31ivig438.3IL4, IL5, IFNG
32allergens438.3SFTPD, IFNG, IL5, IL4, TLR4
33polymyxin b438.2IL4, TLR2, TLR4, IFNG, MBL2
34polyinosinic-polycytidylic acid438.1TLR4, IFNG, IL5, IL4, TLR2
35poly(i-c)438.1TLR2, IL5, IL4, IFNG, TLR4
36il 10438.1IFNG, TLR2, TLR4, IL4, IL5
37tacrolimus43 49 1210.0IL4, TLR2, IL5, IFNG, TLR4
38sb 20358043 599.0IL4, TLR4, TLR2, IL5, IFNG
39nitric oxide43 24 1210.0MBL2, TLR4, IFNG, SFTPD, TLR2
40anti-fungal438.0IL5, MBL2, SFTPD, TLR4, TLR2, IFNG
41cycloheximide438.0IL5, TLR2, TLR4, IFNG, IL4
42actinomycin d438.0IL4, IFNG, CFTR, TLR4, TLR2
43serine437.7MBL2, SFTPD, IL5, CFTR, TLR4, TLR2
44histamine43 28 249.7IL5, IL4, SFTPD, TLR2, TLR4, IFNG
45rantes437.7MBL2, IL5, IL4, IFNG, TLR4, TLR2
46vegf437.7MBL2, IL5, IL4, IFNG, TLR4, TLR2
47cyclosporin a43 28 599.5IL4, TLR2, TLR4, CFTR, IFNG, IL5
48pge2437.5IFNG, TLR2, TLR4, CFTR, IL4, IL5
49cysteine436.8IFNG, TLR4, TLR2, SFTPD, CFTR, IL4
50dexamethasone43 49 28 129.5TLR4, IL4, IL5, MBL2, CLEC7A, CFTR

GO Terms for genes affiliated with Aspergillosis

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Cellular components related to Aspergillosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1collagenGO:00055819.8SFTPD, MBL2
2cell surfaceGO:00099868.8MBL2, CFTR, TLR2
3external side of plasma membraneGO:00098977.8IL4, TLR4, CLEC7A, IFNG, TLR2
4extracellular spaceGO:00056157.8IFNG, IL4, IL5, MBL2, SFTPD

Biological processes related to Aspergillosis according to GeneCards Suite gene sharing:

(show all 37)
idNameGO IDScoreTop Affiliating Genes
1cell surface pattern recognition receptor signaling pathwayGO:000275210.0CLEC7A, TLR2
2cellular response to lipoteichoic acidGO:00712239.9TLR2, TLR4
3positive regulation of macrophage cytokine productionGO:00609079.9TLR2, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:00425359.9TLR4, TLR2
5positive regulation of nitric-oxide synthase biosynthetic processGO:00517709.9TLR2, TLR4
6I-kappaB phosphorylationGO:00072529.8TLR2, TLR4
7positive regulation of chemokine productionGO:00327229.8TLR4, TLR2
8positive regulation of phagocytosisGO:00507669.8SFTPD, CLEC7A, MBL2
9positive regulation of NF-kappaB import into nucleusGO:00423469.8TLR2, TLR4
10positive regulation of interleukin-8 productionGO:00327579.8TLR4, TLR2
11respiratory gaseous exchangeGO:00075859.8CFTR, SFTPD
12positive regulation of interferon-beta productionGO:00327289.8TLR4, TLR2
13lipopolysaccharide-mediated signaling pathwayGO:00316639.7TLR2, TLR4
14defense response to Gram-positive bacteriumGO:00508309.7MBL2, TLR2
15negative regulation of osteoclast differentiationGO:00456719.7TLR4, IL4
16positive regulation of interleukin-12 biosynthetic processGO:00450849.6TLR4, IFNG
17positive regulation of interleukin-6 productionGO:00327559.5TLR4, TLR2
18positive regulation of isotype switching to IgG isotypesGO:00483049.4IL4, IFNG
19positive regulation of B cell proliferationGO:00308909.4TLR4, IL4, IL5
20positive regulation of chemokine biosynthetic processGO:00450809.4IL4, IFNG
21response to cytokineGO:00340979.3IL4, CFTR
22positive regulation of interleukin-10 productionGO:00327339.3IL4, TLR4, TLR2
23positive regulation of inflammatory responseGO:00507299.2TLR4, TLR2
24inflammatory responseGO:00069549.2IL5, CLEC7A, TLR2
25negative regulation of growth of symbiont in hostGO:00441309.2TLR2, IFNG, MBL2
26negative regulation of interleukin-17 productionGO:00327009.1IFNG, TLR4, TLR2
27defense response to protozoanGO:00428329.1IL4, IFNG, CLEC7A
28positive regulation of interleukin-12 productionGO:00327359.1IFNG, TLR4, TLR2
29positive regulation of nitric oxide biosynthetic processGO:00454299.1IFNG, TLR4, TLR2
30positive regulation of MHC class II biosynthetic processGO:00453489.0TLR4, IFNG, IL4
31positive regulation of T cell proliferationGO:00421028.9IFNG, IL4
32defense response to bacteriumGO:00427428.9TLR4, SFTPD, IFNG, MBL2
33innate immune responseGO:00450878.9TLR2, TLR4, SFTPD, CLEC7A, MBL2
34immune responseGO:00069558.8TLR2, TLR4, IL4, IL5
35positive regulation of tumor necrosis factor productionGO:00327608.8IFNG, CLEC7A, TLR4, TLR2
36response to drugGO:00424938.6CFTR, IFNG, IL4
37positive regulation of transcription from RNA polymerase II promoterGO:00459448.3TLR2, TLR4, IFNG, IL4

Molecular functions related to Aspergillosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide receptor activityGO:00018759.5TLR4, TLR2
2signaling pattern recognition receptor activityGO:00083299.5CLEC7A, TLR2
3cytokine activityGO:00051258.3IFNG, IL4, IL5
4protein bindingGO:00055157.2TLR4, SFTPD, CFTR, IL4, IL5, MBL2

Products for genes affiliated with Aspergillosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet