MCID: ASP006
MIFTS: 68

Aspergillosis malady

Infectious category

Summaries for Aspergillosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 34MedlinePlus, 3CDC, 64Wikipedia, 47OMIM, 33MalaCards
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NIH Rare Diseases:43 Aspergillosis is an infection, growth, or allergic response caused by the aspergillus fungus. there are several different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. another kind of aspergillosis is invasive aspergillosis. this infection usually affects people with weakened immune systems due to cancer, aids, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. in this condition, the fungus invades and damages tissues in the body. invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. this type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. the fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. last updated: 10/2/2013

MalaCards: Aspergillosis, also known as aspergillosis, susceptibility to, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis. An important gene associated with Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Th17 Differentiation and Malaria. The drugs flucytosine and miconazole and the compounds mannan and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and spinal cord, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology:8 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. it is a serious illnesses in people with a weakened immune system.

MedlinePlus:34 Aspergillosis is a disease caused by a fungus (or mold) called aspergillus. the fungus is very common in both indoors and outdoors. most people breathe in the spores of the fungus every day without being affected. but some people get the disease. it usually occurs in people with lung diseases or weakened immune systems. there are different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa). symptoms of abpa include wheezing and coughing. abpa can affect healthy people but it is most common in people with asthma or cystic fibrosis. another kind is invasive aspergillosis, which damages tissues in the body. it usually affects the lungs. sometimes it can also cause infection in other organs and spread throughout the body. it affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, and an examination of tissues for signs of the fungus. treatment is with antifungal drugs. if you have abpa, you may also take steroids. centers for disease control and prevention

CDC:3 Aspergillus is a common fungus that can be found in indoor and outdoor environments. Most people breathe in Aspergillus spores every day without being affected. Aspergillosis is a disease caused by this fungus and usually occurs in people with lung diseases or weakened immune systems. The spectrum of illness includes allergic reactions, lung infections, and infections in other organs.

Wikipedia:64 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Description from OMIM:47 614079

Aliases & Classifications for Aspergillosis

Sources:
8Disease Ontology, 43NIH Rare Diseases, 47OMIM, 10DISEASES, 45Novoseek, 49Orphanet, 34MedlinePlus, 61UMLS, 9diseasecard, 35MeSH, 57SNOMED-CT, 27ICD9CM, 40NCIt, 36MESH via Orphanet, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
aspergillosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

aspergillosis 8 43 47 10 45 49 34 61
aspergillosis, susceptibility to 9
infection due to aspergillus 8
aspergillosis, unspecified 8


External Ids:

Disease Ontology8 DOID:13564
MeSH35 D001228
ICD9CM27 117.3
NCIt40 C2886
OMIM47 614079
MESH via Orphanet36 D001228
ICD10 via Orphanet26 B44
SNOMED-CT via Orphanet58 65553006
UMLS via Orphanet62 C0004030
ICD1025 B44, B44.9

Related Diseases for Aspergillosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 267)
idRelated DiseaseScoreTop Affiliating Genes
1invasive aspergillosis31.8TLR2, TLR4
2allergic bronchopulmonary aspergillosis31.8SFTPD, MBL2, IGHE, IL5, IL4, CFTR
3cystic fibrosis31.2SLPI, CFTR, MBL2, SFTPD, TLR4, CCL17
4asthma31.1IGHE, IL4, IL5
5allergic asthma31.1CCL17, TLR4, TLR2, SFTPD, IFNG, IGHE
6chronic granulomatous disease30.7MT-CYB
7sinusitis30.7IGHE, CFTR, IL5
8pulmonary disease, chronic obstructive30.5TLR2, CCR4, SLPI, CFTR, SFTPD
9tuberculosis30.5IL4, TLR1, SFTPD, IFNG, TLR2, MBL2
10pulmonary tuberculosis30.4TLR2, MBL2, IFNG, IL4
11bronchiectasis30.4TLR2, SLPI, CFTR, IGHE, MBL2
12atopy30.2IGHE, IL5, IFNG, TLR2, TLR4, CCL17
13systemic lupus erythematosus30.2CCR4, TLR4, TLR2, IFNG, MBL2, IL4
14allergic rhinitis30.1IGHE, IL4, IL5
15churg-strauss syndrome29.9IL5
16arthritis29.9IFNG, IL4, TLR2, TLR4
17hepatitis c29.9IL4, TLR2, TLR4, IFNG
18pulmonary sarcoidosis29.9SFTPD, CCR4, IFNG
19sepsis29.9TLR4, MBL2, TLR2, SFTPD, TLR1
20atopic dermatitis29.9IL5, IFNG, CCL22, CCR4, CCL17, IGHE
21thyroiditis29.7MBL2
22adenocarcinoma29.7SFTPD
23bronchiolitis29.7TLR4, IGHE, IL5
24acute pancreatitis29.7CFTR, TLR4
25pulmonary alveolar proteinosis29.7SFTPD
26bronchitis29.7SLPI, CFTR, IL5, IGHE
27idiopathic pulmonary fibrosis29.7CCL17, CCR4, SFTPD, CCL22, IFNG
28toxic shock syndrome29.7IFNG
29septic shock29.7TLR4, MBL2, TLR2
30acute leukemia10.6
31zygomycosis10.5
32hematopoietic stem cell transplantation10.4
33invasive mole10.4
34acute myeloid leukemia10.3
35pulmonary aspergilloma10.3
36nocardiosis10.3
37pulmonary sequestration10.1
38acute liver failure10.1
39cryptococcosis10.1
40hepatitis a10.1
41aplastic anemia10.1
42t-cell leukemia10.1
43mycetoma10.1
44influenza, severe10.1
45candidiasis10.0IFNG
46keratoconjunctivitis10.0IL5
47esophagitis10.0IL5
48interstitial lung disease10.0SFTPD
49leprosy10.0TLR2
50cholangitis10.0CFTR

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to aspergillosis

Clinical Features for Aspergillosis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

614079

Drugs & Therapeutics for Aspergillosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Aspergillosis

Search NIH Clinical Center for Aspergillosis

Search CenterWatch for Aspergillosis

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Aspergillosis

Anatomical Context for Aspergillosis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Aspergillosis:

33
Skin, Liver, Spinal cord, Brain, Kidney, Lung, Bone marrow, Whole blood, Heart, Small intestine, Colon, Thyroid, Breast, Prostate, Myeloid, Monocytes, Nk cells, T cells, B lymphoblasts, B cells, Endothelial, Temporal lobe, Pituitary

Animal Models for Aspergillosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Aspergillosis

Sources:
51PubMed
See all sources

Articles related to Aspergillosis:

(show top 50)    (show all 1466)
idTitleAuthorsYear
1
Vertebral aspergillosis in a patient with autosomal-dominant hyper-IgE syndrome. (24197892)
2014
2
Reconstruction of the right atrium using an extracellular matrix patch in a patient with severe mediastinal aspergillosis. (23376511)
2013
3
Myocardial abscess, a rare form of cardiac aspergillosis. (23791602)
2013
4
Invasive aspergillosis caused by cryptic Aspergillus species: a report of two consecutive episodes in a patient with leukaemia. (23161769)
2013
5
Pulmonary aspergillosis and aflatoxins in chronic lung diseases. (23948964)
2013
6
Increased susceptibility for aspergillosis and post-transplant immune deficiency in patients with gene variants of TLR4 after stem cell transplantation. (23890253)
2013
7
Clinical characteristics and treatment outcomes of chronic pulmonary aspergillosis. (23834282)
2013
8
Masaoka approach for invasive aspergillosis: an aggressive approach for an aggressive disease. (22916784)
2012
9
Invasive aspergillosis in children with acquired immunodeficiencies. (22075793)
2012
10
Allergic bronchopulmonary aspergillosis--a clinical review. (23029742)
2012
11
Pharmacokinetic effect of voriconazole on cyclosporine in the treatment of aspergillosis after renal transplantation. (23084335)
2012
12
Galactomannan Antigen Testing for Diagnosis of Invasive Aspergillosis in Pediatric Hematology Patients. (23687575)
2012
13
Voriconazole-induced pancreatitis in a patient of acute myeloid leukemia and invasive aspergillosis. (22713708)
2012
14
Progression of hepatic aspergillosis following second renal transplantation in a patient with recurrent glomerulonephritis. (23455814)
2012
15
Clinical features of invasive pulmonary aspergillosis vs. colonization in COPD patients distributed by gold stage. (22863904)
2012
16
Clinical utility and development of biomarkers in invasive aspergillosis. (21686223)
2011
17
Infection-associated hemophagocytic syndrome among patients with dengue shock syndrome and invasive aspergillosis: a case series and review of the literature. (22299436)
2011
18
Allergic bronchopulmonary aspergillosis in asthma and cystic fibrosis. (21603163)
2011
19
Acute liver failure may lead to lethal pulmonary aspergillosis. (20216429)
2010
20
Early proinflammatory cytokines and Ca89reactive protein trends as predictors of outcome in invasive Aspergillosis. (20879853)
2010
21
TNFR1 mRNA expression level and TNFR1 gene polymorphisms are predictive markers for susceptibility to develop invasive pulmonary aspergillosis. (20646338)
2010
22
Aspirin induced asthma accompanied with allergic bronchopulmonary aspergillosis: a case report. (21034574)
2010
23
Use of PCR for diagnosis of invasive aspergillosis: systematic review and meta-analysis. (19179225)
2009
24
Allergic bronchopulmonary aspergillosis. (19265090)
2009
25
Aspergillus/allergic bronchopulmonary aspergillosis in an Irish cystic fibrosis population: a diagnostically challenging entity. (18655741)
2008
26
Potential of lung surfactant proteins, SP-A and SP-D, and mannan binding lectin for therapy and genetic predisposition to allergic and invasive aspergillosis. (19075981)
2007
27
Distinct alleles of mannose-binding lectin (MBL) and surfactant proteins A (SP-A) in patients with chronic cavitary pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. (17311505)
2007
28
The debate: a case for randomized controls in invasive aspergillosis. (17050456)
2006
29
Incidence of invasive aspergillosis among allogeneic hematopoietic stem cell transplant patients receiving voriconazole prophylaxis. (16626917)
2006
30
Role of collectins in innate immunity against aspergillosis. (16114131)
2005
31
Chronic necrotising pulmonary aspergillosis: a rare complication in a case of silicosis. (16022149)
2005
32
Concurrent sino-orbital aspergillosis and cerebral nocardiosis. (15179067)
2004
33
Frequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis. (11243954)
2001
34
Therapy of allergic bronchopulmonary aspergillosis. (15597668)
2000
35
Allergic bronchopulmonary aspergillosis in Italian cystic fibrosis patients: prevalence and percentage of positive tests in the employed diagnostic criteria. (11297226)
2000
36
Hilar adenopathy in allergic bronchopulmonary aspergillosis. (10353584)
1999
37
Antifungals in the treatment of allergic bronchopulmonary aspergillosis. (10400477)
1999
38
Successful treatment of fungus ball in a patient with allergic bronchopulmonary aspergillosis: continuous percutaneous instillation of antifungal agents into the cavity. (8915703)
1996
39
Improved diagnosis of allergic bronchopulmonary aspergillosis with gp66 (formerly antigen 7) of Aspergillus fumigatus for specific IgE detection. (8765818)
1996
40
Allergic bronchopulmonary aspergillosis: a case report. (7674424)
1995
41
Management of allergic bronchopulmonary aspergillosis. (8029520)
1994
42
Allergic bronchopulmonary aspergillosis: a report of three cases. (8174015)
1994
43
Application of enzyme-immunohistochemistry for the diagnosis of aspergillosis, candidiasis, and zygomycosis in three lovebirds. (8257396)
1993
44
Management of allergic bronchopulmonary aspergillosis. (8379995)
1993
45
Crossed immunoelectrophoresis of fungal antigens in tissues as a means of diagnosing systemic aspergillosis and zygomycosis in cattle. (8146952)
1993
46
Allergic bronchopulmonary aspergillosis in a child. (2122950)
1990
47
Chronic sinusitis caused by zygomycosis and aspergillosis. (2497008)
1989
48
Pathologic features of allergic bronchopulmonary aspergillosis. (3344888)
1988
49
Serum IgA antibodies to Aspergillus fumigatus in various stages of allergic bronchopulmonary aspergillosis. (3522709)
1986
50
Allergic bronchopulmonary aspergillosis complicating cystic fibrosis in childhood. (7002053)
1980

Genetic Variations for Aspergillosis

Expression for genes affiliated with Aspergillosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Aspergillosis

Search GEO for disease gene expression data for Aspergillosis.

Pathways for genes affiliated with Aspergillosis

Sources:
53R&D Systems, 30KEGG, 12EMD Millipore, 52QIAGEN, 38NCBI BioSystems Database, 54Reactome, 4Cell Signaling Technology, 60Tocris Bioscience
See all sources

Pathways related to Aspergillosis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TLR1
210.4TLR4, TLR2
310.4IL4, IL5
410.4TLR2, IL5, IL4
510.4TLR4, TLR2, IFNG
610.4IFNG, TLR2, TLR4
710.4IFNG, IL5, IL4
810.4IL4, IL5, IFNG
910.4IL4, IL5, IFNG
10
Hide members
10.4IL4, IL5, IFNG
1110.4IL4, IL5, IFNG
1210.4SFTPD, SFTPA2, SFTPA1
1310.4SFTPD, SFTPA2, SFTPA1
1410.4TLR1, TLR2, TLR4
1510.4TLR4, SFTPA1, SFTPA2
1610.4TLR4, TLR2, TLR1, CLEC7A
17
Hide members
10.4CLEC7A, TLR1, TLR2, TLR4
18
Hide members
10.4IL5, TLR1, TLR2, TLR4
1910.4TLR4, TLR2, TLR1, IFNG
20
Hide members
10.4TLR4, TLR2, TLR1, IFNG
21
Hide members
10.4IFNG, TLR1, TLR2, TLR4
2210.4CCL17, CCR4, CCL22
23
Hide members
10.4IL4, IL5, IGHE, IFNG
24
Hide members
10.4IL4, IL5, IFNG, TLR2, TLR4
2510.4CCL17, IGHE, IL5, IL4
2610.4TLR4, TLR2, TLR1, IFNG, CLEC7A
27
Hide members
10.4TLR4, TLR2, TLR1, IFNG, IL4
28
Hide members
10.4IL4, IL5, IFNG, CCL17, CCL22
2910.4TLR4, TLR2, TLR1, SFTPA1, IL4
30
Hide members
10.4CCL22, CCR4, CCL17, TLR4, IL5
3110.4TLR4, TLR2, SFTPA1, SFTPA2, SFTPD, MBL2
32
Hide members
10.4CCL22, CCR4, CCL17, IL5, IL4
33
Immune response Bacterial infections in normal airways
10.3CFTR, TLR4, TLR2, TLR1, SFTPA1, SFTPD
34
Hide members
10.3TLR4, TLR2, TLR1, IFNG, MBL2, IGHE
35
Hide members
10.3CCL22, CCR4, CCL17, TLR4, TLR2, TLR1

Compounds for genes affiliated with Aspergillosis

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB, 2BitterDB
See all sources

Compounds related to Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1mannan4510.8SFTPD, MBL3P, TLR2, MBL2, TLR4
2cycloheximide4510.8MT-CYB, TLR2
3polymyxin b4510.8TLR4, TLR2, MBL2, IL4, IFNG
4imiquimod45 29 60 1113.8TLR1, IFNG, TLR2, TLR4, IL5
5rantes4510.8TLR4, TLR2, IFNG, MBL2, IL4, SLPI
6il 104510.8CCL17, TLR4, TLR2, IL5, IL4, IFNG
7polyinosinic-polycytidylic acid4510.8IFNG, TLR2, TLR4, IL5, IL4
8budesonide45 50 1112.8IGHE, IL4, SFTPD, IFNG, IL5
9anti-fungal4510.8SLPI, IFNG, IL5, SFTPD, TLR2, TLR4
10zymosan4510.8CLEC7A, TLR4, TLR2, MBL2
11poly(i-c)4510.8TLR2, IFNG, IL5, TLR4, IL4
12lipoteichoic acid4510.8MBL2, TLR4, TLR2, TLR1, SLPI
13allergens4510.8TLR4, IL4, IL5, IGHE, IFNG, SFTPD
14pam3csk46010.8TLR2, TLR4, TLR1
15ccl345 2911.8CCR4, TLR4, CCL17, IFNG, CCL22, TLR2
16prednisolone45 29 1112.8IL5, SFTPD, MBL2, IGHE, CCR4
17poly(i:c)6010.8TLR4, TLR2, TLR1
18fluticasone propionate45 50 60 1113.8SLPI, IFNG, IGHE, IL5, IL4
19tacrolimus45 50 1112.8CCL22, IL5, CCL17, TLR4, IL4, TLR2
20cyclosporin a45 29 6012.8IFNG, CCL17, CCL22, SLPI, IGHE, CFTR
21mannose4510.8MBL2, CLEC7A, SFTPD, MBL3P, TLR2, TLR4
22omalizumab45 1111.8IGHE, IL5, IL4
23pam2csk46010.8TLR1, TLR2, TLR4
24tarc4510.8IL4, CCL22, CCL17, IFNG, CCR4, IGHE
25methacholine45 1111.8IL5, CCL22, IGHE, SLPI, IL4
26con a4510.7IFNG, IL5, IL4, MBL2
27histamine45 29 2412.7TLR4, CCL22, SLPI, TLR2, SFTPD, IL4
28hydrocortisone45 2 60 1113.7SLPI, IGHE
29vitamin d4510.7TLR2, TLR4, IL5, SLPI, MBL2, IGHE
30actinomycin d4510.7CFTR, SLPI, IL4, IGHE, IFNG, TLR2
31sb 20358045 6011.7CCL22, TLR4, IL5, IFNG, IL4, TLR2
32resiquimod45 6011.7TLR1, TLR2, TLR4
33cysteine4510.7SLPI, IL5, IL4, IFNG, TLR2, TLR4
34dexamethasone45 50 29 1113.7CCL17, SLPI, CFTR, IL4, IL5, CLEC7A
35polysaccharide4510.7IGHE, MBL2, MBL3P, SFTPD, TLR2, TLR4
36vegf4510.6TLR2, IL5, IGHE, MBL2, IL4, IFNG
37agarose4510.6TLR2, SFTPD, SLPI, MBL2, TLR4
38fibrinogen4510.6CCL22, SLPI, MBL2, TLR2, TLR4, CCL17
39carbohydrates4510.6CFTR, MBL2, SFTPD, TLR4, IGHE
40nitric oxide45 11 2412.6CCL17, SLPI, MT-CYB, MBL2, IFNG, SFTPD
41ovomucoid4510.6IL5, IGHE, IL4
42simvastatin45 50 60 29 11 2415.6TLR2, TLR4, CCR4, IL4, IFNG
43endotoxin4510.6SLPI
44infliximab45 50 1112.5IL4, IGHE, IFNG, TLR4
45peptidoglycan45 2911.5TLR1, MBL2, TLR2, TLR4
46calcium45 50 11 2413.4SLPI, MBL2, SFTPD, SFTPA2, SFTPA1, MT-CYB
47ivig4510.4IL4, IGHE, IFNG, IL5
48nedocromil sodium4510.3IGHE, IL5, IL4
49retinoic acid45 2411.3CFTR, IL5, IGHE, IFNG, TLR2, SLPI
50ccl445 2911.1CCL22, CCR4, CCL17, TLR2

GO Terms for genes affiliated with Aspergillosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.4TLR1, TLR2
2extracellular spaceGO:00561510.4IL4, CCL22, CCL17, SFTPA1, SFTPA2, SFTPD
3external side of plasma membraneGO:00989710.4CCR4, TLR4, TLR2, IFNG, CLEC7A, IL4
4extracellular regionGO:00557610.2CCL22, CCL17, SFTPA1, SFTPA2, SFTPD, IFNG
5collagenGO:00558110.1SFTPA1, SFTPA2, SFTPD, MBL2

Biological processes related to Aspergillosis according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.8TLR4, IFNG, IL4
2positive regulation of tumor necrosis factor productionGO:03276010.8TLR4, TLR2, IFNG, CLEC7A
3negative regulation of interleukin-17 productionGO:03270010.8IFNG, TLR2, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:04253510.8TLR4, TLR2, TLR1
5positive regulation of phagocytosisGO:05076610.8SFTPD, MBL2, CLEC7A
6negative regulation of growth of symbiont in hostGO:04413010.8MBL2, IFNG, TLR2
7respiratory gaseous exchangeGO:00758510.8CFTR, SFTPD, SFTPA2, SFTPA1
8defense response to protozoanGO:04283210.8IFNG, CLEC7A, IL4
9positive regulation of interleukin-12 productionGO:03273510.8TLR4, TLR2, IFNG
10cell surface pattern recognition receptor signaling pathwayGO:00275210.8TLR2, CLEC7A
11cellular response to triacyl bacterial lipopeptideGO:07172710.8TLR2, TLR1
12detection of triacyl bacterial lipopeptideGO:04249510.8TLR2, TLR1
13positive regulation of nitric oxide biosynthetic processGO:04542910.7IFNG, TLR2, TLR4
14positive regulation of B cell proliferationGO:03089010.7TLR4, IL5, IL4
15inflammatory responseGO:00695410.7CCL22, CCR4, CCL17, TLR2, TLR1, CLEC7A
16innate immune responseGO:04508710.7TLR4, TLR2, TLR1, SFTPD, MBL2, IGHE
17positive regulation of macrophage cytokine productionGO:06090710.7TLR4, TLR2
18detection of diacyl bacterial lipopeptideGO:04249610.7TLR1, TLR2
19positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
20chemotaxisGO:00693510.7CCL22, CCR4, CCL17, IL4
21cellular response to lipoteichoic acidGO:07122310.7TLR4, TLR2
22immune responseGO:00695510.7IL4, CCL22, CCR4, CCL17, TLR4, TLR2
23regulation of cytokine secretionGO:05070710.7TLR4, TLR1
24positive regulation of interleukin-6 biosynthetic processGO:04541010.6TLR1, IFNG
25positive regulation of interleukin-12 biosynthetic processGO:04508410.6TLR4, IFNG
26positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, IL4
27macrophage activationGO:04211610.5TLR4, TLR1
28MyD88-dependent toll-like receptor signaling pathwayGO:00275510.5TLR1, TLR2, TLR4
29positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.4TLR4, TLR2
30defense response to bacteriumGO:04274210.4MBL2, IFNG, TLR4
31I-kappaB phosphorylationGO:00725210.3TLR4, TLR2
32T-helper 1 type immune responseGO:04208810.1TLR1, TLR4

Molecular functions related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.4TLR1, TLR2, TLR4
2carbohydrate bindingGO:03024610.4CLEC7A, SFTPD, SFTPA2, SFTPA1
3lipopolysaccharide receptor activityGO:00187510.3TLR4, TLR2
4signaling pattern recognition receptor activityGO:00832910.1CLEC7A, TLR2

Products for genes affiliated with Aspergillosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aspergillosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet