Aspergillosis malady

Categories: Genetic diseases, Rare diseases, Infectious diseases

Aliases & Classifications for Aspergillosis

Aliases & Descriptions for Aspergillosis:

Name: Aspergillosis 54 12 50 56 52 41 3 42 14 69
Aspergillosis, Susceptibility to 54 29 13
Infection Due to Aspergillus 12


Orphanet epidemiological data:

Inheritance: Not applicable; Age of onset: All ages;


Orphanet: 56  
Rare infectious diseases

External Ids:

OMIM 54 614079
Disease Ontology 12 DOID:13564
ICD10 33 B44 B44.9
ICD9CM 35 117.3
MeSH 42 D001228
NCIt 47 C2886
Orphanet 56 ORPHA1163
MESH via Orphanet 43 D001228
UMLS via Orphanet 70 C0004030
ICD10 via Orphanet 34 B44.0 B44.1 B44.2 more
UMLS 69 C0004030

Summaries for Aspergillosis

NIH Rare Diseases : 50 aspergillosis is an infection, growth, or allergic response caused by the aspergillus fungus. there are several different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. another kind of aspergillosis is invasive aspergillosis. this infection usually affects people with weakened immune systems due to cancer, aids, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. in this condition, the fungus invades and damages tissues in the body. invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. this type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. the fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. last updated: 10/2/2013

MalaCards based summary : Aspergillosis, also known as aspergillosis, susceptibility to, is related to hepatitis and pulmonary tuberculosis, and has symptoms including fever and pruritus. An important gene associated with Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

OMIM : 54 Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization... (614079) more...

MedlinePlus : 41 aspergillosis is a disease caused by a fungus (or mold) called aspergillus. the fungus is very common in both indoors and outdoors. most people breathe in the spores of the fungus every day without being affected. but some people get the disease. it usually occurs in people with lung diseases or weakened immune systems. there are different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa). symptoms of abpa include wheezing and coughing. abpa can affect healthy people but it is most common in people with asthma or cystic fibrosis. another kind is invasive aspergillosis, which damages tissues in the body. it usually affects the lungs. sometimes it can also cause infection in other organs and spread throughout the body. it affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, and an examination of tissues for signs of the fungus. treatment is with antifungal drugs. if you have abpa, you may also take steroids. centers for disease control and prevention

CDC : 3 Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus. The types of health problems caused by Aspergillus include allergic reactions, lung infections, and infections in other organs.

Wikipedia : 71 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Related Diseases for Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
id Related Disease Score Top Affiliating Genes
1 hepatitis 30.0 CLEC7A IFNG IL10
2 pulmonary tuberculosis 29.8 IFNG IL10 IL4 IL5 TLR4
3 middle lobe syndrome 29.7 CCL17 IL10 IL5
4 polyarteritis nodosa 29.4 IFNG TLR2 TLR4
5 aseptic meningitis 29.3 CCL17 TLR2 TLR4
6 clostridium difficile colitis 29.3 CD79A IFNG IL4
7 pulmonary eosinophilia 29.2 IFNG IL10 MBL2 TLR2
8 esophageal candidiasis 29.2 IFNG IL10 IL4
9 histiocytosis 28.9 CD79A ELANE TLR2 TLR4
10 rheumatoid arthritis 28.9 CD79A CSF2 IFNG IL10 IL4 TLR2
11 exophthalmos 28.8 CD209 IFNG IL10 IL4
12 allergic bronchopulmonary aspergillosis 12.4
13 invasive aspergillosis 12.3
14 allergic bronchopulmonary aspergillosis, familial 11.9
15 pulmonary aspergilloma 11.1
16 plastic bronchitis 10.8
17 neuroaspergillosis 10.8
18 cystic fibrosis 10.4
19 myoglobinuria recurrent 10.3 IFNG IL4
20 gonococcal synovitis 10.3 CLEC7A MBL2 TLR4
21 pseudoainhum 10.3 MBL2 TLR2 TLR4
22 gastroschisis abdominal wall defects, included 10.3 IFNG IL5
23 nephropathy familial with hyperuricemia 10.2 MBL2 TLR2 TLR4
24 tubular renal disease-cardiomyopathy syndrome 10.2 IL10 IL4
25 multiple epiphyseal dysplasia due to collagen 9 anomaly 10.2 IFNG IL4 IL5
26 asthma 10.2
27 urethral intrinsic sphincter deficiency 10.2 IFNG IL4 IL5
28 acute gonococcal prostatitis 10.2 IFNG IL4 IL5
29 hyperlucent lung 10.2 IFNG TLR2 TLR4
30 cutaneous fibrous histiocytoma 10.2 IFNG IL4 IL5
31 isolated klippel-feil syndrome 10.2 IFNG IL4 IL5
32 asymptomatic neurosyphilis 10.2 IFNG IL10 IL4
33 tungiasis 10.2 IFNG IL10 IL4
34 parkinson disease 11 10.2 IFNG IL10 TLR4
35 duodenal somatostatinoma 10.2 IL4 IL5 TLR4
36 centronuclear myopathy 5 10.2 IFNG IL10 IL4
37 hydrophthalmos 10.2 IFNG IL4 IL5
38 neurotic disorder 10.2 IFNG IL10 IL4
39 malignant renovascular hypertension 10.2 CD79A IFNG
40 ectodermal dysplasia bartalos type 10.2 IFNG IL10 IL4
41 mycoplasmal pneumonia 10.2 CFTR CLEC7A TLR2
42 acute myeloid leukemia with recurrent genetic anomaly 10.2 IFNG IL10 IL4
43 leukemia 10.2
44 choledochal cyst 10.2 CSF2 IL5
45 thyroid hyalinizing trabecular adenoma 10.2 IFNG IL4 IL5
46 otulipenia 10.2 CSF2 IFNG MBL2
47 leukoplakia of penis 10.2 IL10 IL4 TLR2
48 autosomal recessive type iv ehlers-danlos syndrome 10.2 IL10 IL4 TLR4
49 microcephaly 10.2 IFNG IL10 TLR2
50 paralytic poliomyelitis 10.2 IFNG TLR4

Comorbidity relations with Aspergillosis via Phenotypic Disease Network (PDN):

Bronchiectasis Bronchitis
Deficiency Anemia Heart Disease
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Aspergillosis:

Diseases related to Aspergillosis

Symptoms & Phenotypes for Aspergillosis

Clinical features from OMIM:


UMLS symptoms related to Aspergillosis:

fever, pruritus

MGI Mouse Phenotypes related to Aspergillosis:

id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 IL4 IL5 MBL2 SFTPD TLR2 TLR4
2 homeostasis/metabolism MP:0005376 10.22 CD79A CFTR CLEC7A CSF2 ELANE IFNG
3 immune system MP:0005387 10.21 CCL17 CD79A CFTR CLEC7A CSF2 ELANE
4 digestive/alimentary MP:0005381 10.06 CFTR CLEC7A IFNG IL10 IL4 IL5
5 liver/biliary system MP:0005370 9.92 TLR2 TLR4 CD79A CFTR IFNG IL10
6 neoplasm MP:0002006 9.86 CD79A CSF2 ELANE IFNG IL10 IL5
7 normal MP:0002873 9.76 CD79A CFTR ELANE IFNG IL10 IL4
8 renal/urinary system MP:0005367 9.5 CD79A CSF2 IFNG IL4 MBL2 TLR2
9 respiratory system MP:0005388 9.32 TLR4 CFTR CLEC7A CSF2 IFNG IL10

Drugs & Therapeutics for Aspergillosis

Drugs for Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 129)
id Name Status Phase Clinical Trials Cas Number PubChem Id
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 14956 5280965
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 22916-47-8 4189
Voriconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 137234-62-9 71616
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1 179463-17-3, 162808-62-0 468682 2826718
Guaifenesin Approved, Vet_approved Phase 4 93-14-1 3516
Itraconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 84625-61-6 55283
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 3081921 477468
Omalizumab Approved, Investigational Phase 4 242138-07-4
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
Mycophenolic acid Approved Phase 4 24280-93-1 446541
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
14 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
15 Antifungal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
16 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
22 Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
23 Hormones Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
25 Steroid Synthesis Inhibitors Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1
26 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1
27 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Early Phase 1
28 Antitussive Agents Phase 4
29 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
30 Hydroxyitraconazole Phase 4,Phase 2,Phase 3,Early Phase 1
31 Anti-Allergic Agents Phase 4,Phase 2,Phase 3
32 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3
33 Respiratory System Agents Phase 4,Phase 2,Phase 3
34 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
35 glucocorticoids Phase 4,Phase 2,Phase 3
36 Antibodies Phase 4
37 Immunoglobulin E Phase 4
38 Immunoglobulins Phase 4
39 Immunosuppressive Agents Phase 4,Phase 1
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
deoxycholic acid Approved Phase 3,Phase 2 83-44-3 222528
Budesonide Approved Phase 2, Phase 3 51333-22-3 63006 5281004
Fluconazole Approved Phase 3,Phase 1 86386-73-4 3365
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
Cholecalciferol Approved, Nutraceutical Phase 2, Phase 3, Phase 1 67-97-0 6221 10883523 5280795
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3,Phase 1 50-14-6 5280793
49 Methylprednisolone acetate Phase 2, Phase 3
50 Methylprednisolone Hemisuccinate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 155)
id Name Status NCT ID Phase
1 Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation Unknown status NCT00986713 Phase 4
2 Voriconazole for IPA in Chinese Patients With COPD Unknown status NCT02234739 Phase 4
3 Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease Unknown status NCT01499433 Phase 4
4 Aspergillus PCR Early Detection in High Risk Oncohematological Patients Unknown status NCT01742026 Phase 4
5 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4
6 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4
7 Voriconazole Prophylaxis Against Aspergillosis in Lung Transplant Recipients Completed NCT00177827 Phase 4
8 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4
9 A Study To Assess The Anidulafungin And Voriconazole Concentration In Lung Following Intravenous Administration In Healthy Subjects Completed NCT00940017 Phase 4
10 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4
11 King's Invasive Aspergillosis Study II Not yet recruiting NCT02875743 Phase 4
12 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4
13 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4
14 An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complicated by Acute Bronchopulmonary Aspergillosis (ABPA) Terminated NCT00787917 Phase 4
15 Post Marketing Study to Evaluate the Safety and Efficacy of Micafungin Against Fungal Infections Caused by Candida Spp or Aspergillus Spp Terminated NCT02646800 Phase 4
16 Comparison of 2 Antifungal Treatment (Empirical Versus Pre-Empirical) Strategies in Prolonged Neutropenia Terminated NCT00190463 Phase 4
17 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4
18 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4
19 Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection. Withdrawn NCT02020213 Phase 4
20 Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis Unknown status NCT01125644 Phase 3
21 Voriconazole For Chronic Bronchopulmonary Aspergillosis Completed NCT00159822 Phase 2, Phase 3
22 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3
23 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3
24 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3
25 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
26 Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3
27 Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary Aspergillosis Completed NCT01621321 Phase 2, Phase 3
28 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3
29 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3
30 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3
31 A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Completed NCT01857479 Phase 2, Phase 3
32 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3
33 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3
34 Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Completed NCT01321827 Phase 2, Phase 3
35 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001810 Phase 3
36 Comparing the Effectiveness of Fluconazole and a New Medicine (FK463) in Preventing Fungal Infections in Bone Marrow Transplant Patients Completed NCT00001937 Phase 3
37 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3
38 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3
39 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3
40 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001757 Phase 3
41 A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED) Completed NCT00717860 Phase 3
42 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3
43 Voriconazole to Treat Fungal Infections Completed NCT00001940 Phase 3
44 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3
45 A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis Recruiting NCT02440009 Phase 2, Phase 3
46 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3
47 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Recruiting NCT02180165 Phase 3
48 Caspofungin Acetate or Fluconazole in Preventing Invasive Fungal Infections in Patients With Acute Myeloid Leukemia Who Are Undergoing Chemotherapy Active, not recruiting NCT01307579 Phase 3
49 A Study Evaluating Vitamin D in Allergic Bronchopulmonary Aspergillosis Complicating Asthma Not yet recruiting NCT03133299 Phase 2, Phase 3
50 A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children Terminated NCT00836875 Phase 3

Search NIH Clinical Center for Aspergillosis

Inferred drug relations via UMLS 69 / NDF-RT 48 :

Cochrane evidence based reviews: aspergillosis

Genetic Tests for Aspergillosis

Genetic tests related to Aspergillosis:

id Genetic test Affiliating Genes
1 Aspergillosis, Susceptibility to 29

Anatomical Context for Aspergillosis

MalaCards organs/tissues related to Aspergillosis:

Lung, Testes, Kidney, Brain, Bone, Heart, Colon

Publications for Aspergillosis

Articles related to Aspergillosis:

(show top 50) (show all 1773)
id Title Authors Year
Possible relationship between organizing pneumonia and chronic pulmonary aspergillosis: A case report and literature review. ( 28012499 )
Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia. ( 27815226 )
Development of Aspergillosis in a cohort of non-neutropenic, non-transplant patients colonised by Aspergillus spp. ( 28056830 )
Beneficial effects of Omalizumab therapy in allergic bronchopulmonary aspergillosis: A synthesis review of published literature. ( 27993289 )
Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients. ( 27795339 )
Case series of omalizumab for allergic bronchopulmonary aspergillosis in cystic fibrosis patients. ( 27717223 )
7th Advances Against Aspergillosis: Basic, diagnostic, clinical and therapeutic studies. ( 27994098 )
Cost-Effectiveness Analysis of Isavuconazole vs. Voriconazole as First-Line Treatment for Invasive Aspergillosis. ( 27913989 )
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
Intracranial Aspergillosis in an Immunocompetent Young Woman. ( 28054219 )
Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis: MR Imaging of Airway Mucus Contrasts as a Tool for Diagnosis. ( 28530849 )
Increasing Total Serum IgE, Allergic Bronchopulmonary Aspergillosis, and Lung Function in Cystic Fibrosis. ( 28526275 )
Serial assessment of pulmonary lesion volume by computed tomography allows survival prediction in invasive pulmonary aspergillosis. ( 28083695 )
Renal aspergillosis after liver transplant: Report of an unusual case. ( 28089360 )
Two cases of non-cystic fibrosis (CF) bronchiectasis with allergic bronchopulmonary aspergillosis. ( 28053855 )
Invasive aspergillosis in acute myeloid leukemia: Are we making progress in reducing mortality? ( 27915304 )
Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis. ( 26585435 )
PCR-based detection of Aspergillus fumigatus Cyp51A mutations on bronchoalveolar lavage: a multicentre validation of the AsperGenius assayAr in 201 patients with haematological disease suspected for invasive aspergillosis. ( 27530755 )
Role of Aspergillus fumigatus-specific IgG in diagnosis and monitoring treatment response in allergic bronchopulmonary aspergillosis. ( 27523578 )
Pulmonary hydatid cyst with co-existent aspergillosis: A rare cytology finding. ( 27177687 )
Molecular-based allergy diagnosis of allergic bronchopulmonary aspergillosis in Aspergillus fumigatus-sensitized Japanese patients. ( 26817858 )
Outcomes of Bronchial Artery Embolization for Life-Threatening Hemoptysis in Patients with Chronic Pulmonary Aspergillosis. ( 28006828 )
Reducing hypoxia and inflammation during invasive pulmonary aspergillosis by targeting the Interleukin-1 receptor. ( 27215684 )
New therapeutic strategies for invasive aspergillosis in the era of azole resistance: how should the prevalence of azole resistance be defined? ( 27494830 )
Basophil activation test determination of CD63 combined with CD203c is not superior to CD203c alone in identifying allergic bronchopulmonary aspergillosis in cystic fibrosis. ( 27215492 )
Allergic bronchopulmonary aspergillosis in asthma. ( 27599560 )
Sequential Sonographic Features of Primary Invasive Aspergillosis Involving Only the Thyroid Gland: A Case Report and Literature Review. ( 27110341 )
Delayed diagnosis of allergic bronchopulmonary aspergillosis due to absence of asthmatic symptoms. ( 27489792 )
Invasive Aspergillosis Mimicking Sphenoid Wing Meningioma. ( 27977495 )
Neonatal Cutaneous Invasive Aspergillosis Accompanied by Hemophagocytic Lymphohistocytosis. ( 27977554 )
Common invasive fungal diseases: an overview of invasive candidiasis, aspergillosis, cryptococcosis, and Pneumocystis pneumonia. ( 26901377 )
Childhood allergic bronchopulmonary aspergillosis presenting as a middle lobe syndrome. ( 26844222 )
Human Immunodeficiency Virus and Allergic Bronchopulmonary Aspergillosis: Case Report and Review of Literature. ( 27419184 )
Allergic bronchopulmonary aspergillosis complicating Swyer-James-Macleod's syndrome: case report and review of literature. ( 27152607 )
The influence of the control group characteristics for the diagnostic performance of 1,3-beta-D-glucan in invasive aspergillosis. ( 27663204 )
Invasive Aspergillosis of the Stomach and Co-infection With Candida krusei in a Patient With Terminal Liver Failure: A Case Report. ( 27932169 )
Diagnosis of Invasive Pulmonary Aspergillosis. ( 27645542 )
Treating allergic bronchopulmonary aspergillosis: the way forward. ( 26828049 )
Tracheoesophageal fistula induced by invasive pulmonary aspergillosis. ( 27761449 )
Cerebral aspergillosis and pulmonary tuberculosis in a child with chronic granulomatous disease. ( 27308089 )
Are allergic fungal rhinosinusitis and allergic bronchopulmonary aspergillosis lifelong conditions? ( 27601608 )
Radiologic Criteria for the Diagnosis of High-Attenuation Mucus in Allergic Bronchopulmonary Aspergillosis. ( 27055707 )
Clinical manifestations and outcomes of pulmonary aspergillosis: experience from Pakistan. ( 28074136 )
Safety, Efficacy, and Exposure-Response of Voriconazole in Pediatric Patients with Invasive Aspergillosis, Invasive Candidiasis, or Esophageal Candidiasis. ( 27636722 )
"Blood basophil activation is a reliable biomarker of allergic bronchopulmonary aspergillosis in cystic fibrosis." Yael Gernez, Jeffrey Waters, Bojana MirkoviA8, Gillian M. Lavelle, Colleen E. Dunn, Zoe A. Davies, Cassie Everson, Rabindra Tirouvanziam, Elana Silver, Sylvan Wallenstein, Sanjay H. Chotirmall, Noel G. McElvaney, Leonore A. Herzenberg and Richard B. Moss. Eur Respir J 2016; 47: 177-185. ( 27246085 )
Combination Antifungal Therapy for Invasive Aspergillosis Revisited. ( 27441304 )
Severe acute pancytopaenia in a patient with rheumatoid arthritis complicated by fatal invasive pulmonary aspergillosis. ( 27575284 )
Blood Aspergillus RNA is a promising alternative biomarker for invasive aspergillosis. ( 27335056 )
Invasive aspergillosis successfully treated by combined antifungal therapy and immunosuppressive monotherapy two months following heart transplantation. ( 27516796 )
Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium. ( 26667837 )

Variations for Aspergillosis

ClinVar genetic disease variations for Aspergillosis:

id Gene Variation Type Significance SNP ID Assembly Location
1 CLEC7A NM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter) single nucleotide variant risk factor rs16910526 GRCh37 Chromosome 12, 10271087: 10271087

Expression for Aspergillosis

Search GEO for disease gene expression data for Aspergillosis.

Pathways for Aspergillosis

Pathways related to Aspergillosis according to GeneCards Suite gene sharing:

(show all 44)
id Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
13.36 CCL17 CSF2 IL10 IL4 IL5 TLR2
Show member pathways
Show member pathways
12.76 CD209 IFNG IL4 TLR2 TLR4
5 12.54 CD79A IFNG IL10 IL4 TLR2
Show member pathways
12.54 IFNG IL10 IL4 IL5 TLR2 TLR4
Show member pathways
12.52 CD79A CSF2 IL4 IL5
Show member pathways
12.44 CSF2 IFNG IL10 IL4 IL5
Show member pathways
12.25 IFNG IL10 IL4 TLR2 TLR4
Show member pathways
12.17 CSF2 IFNG IL10 IL4 IL5
Show member pathways
12.16 IFNG IL10 IL4 IL5
12 12.16 CD209 CLEC7A IFNG IL10 TLR2 TLR4
Show member pathways
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Show member pathways
11.96 IFNG IL10 TLR2 TLR4
16 11.95 IFNG IL4 TLR4
Show member pathways
11.93 IFNG IL4 TLR2 TLR4
18 11.87 CSF2 IFNG TLR2 TLR4
19 11.86 CSF2 IFNG IL10 TLR2 TLR4
20 11.85 CSF2 IL4 IL5
Show member pathways
11.83 CFTR CSF2 TLR4
22 11.82 CSF2 IFNG IL4 IL5
23 11.8 IFNG IL10 IL4 IL5
24 11.79 CSF2 IFNG TLR4
25 11.78 CLEC7A TLR2 TLR4
Show member pathways
11.77 CSF2 IFNG IL4 IL5
27 11.77 CD209 CSF2 IFNG IL10
28 11.73 IL10 SFTPA2 TLR4
30 11.66 CCL17 IL10 IL4 IL5
31 11.65 CSF2 IL4 IL5 SFTPA2
32 11.65 IL10 IL4 IL5 TLR2 TLR4
33 11.53 CSF2 IL10 IL4
34 11.52 IFNG TLR2 TLR4
35 11.49 IFNG IL10 TLR2 TLR4
Show member pathways
11.43 CSF2 IFNG IL10
37 11.39 CCL17 IFNG IL10 IL4 IL5
38 11.34 IFNG IL4 IL5
39 11.32 IFNG IL4 IL5
40 11.24 CD209 CD79A CSF2 IFNG IL10 IL4
41 11.2 CCL17 CSF2 IL10 IL4 IL5
42 11.17 IFNG IL10 IL4 IL5
43 11.03 CSF2 IFNG IL10 IL4 IL5
44 10.86 IL4 IL5

GO Terms for Aspergillosis

Cellular components related to Aspergillosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.73 CD209 CFTR ELANE MBL2 TLR2 TLR4
2 extracellular region GO:0005576 9.7 CCL17 CD209 CSF2 ELANE IFNG IL10
3 external side of plasma membrane GO:0009897 9.55 CD209 CD79A IFNG IL4 TLR4
4 collagen trimer GO:0005581 9.54 MBL2 SFTPA2 SFTPD
5 clathrin-coated endocytic vesicle GO:0045334 9.4 SFTPA2 SFTPD
6 lamellar body GO:0042599 9.32 SFTPA2 SFTPD
7 extracellular space GO:0005615 9.32 CCL17 CSF2 ELANE IFNG IL10 IL4

Biological processes related to Aspergillosis according to GeneCards Suite gene sharing:

(show all 39)
id Name GO ID Score Top Affiliating Genes
1 innate immune response GO:0045087 9.95 CD209 CLEC7A MBL2 SFTPD TLR2 TLR4
2 inflammatory response GO:0006954 9.91 CCL17 CLEC7A IL10 IL5 TLR2 TLR4
3 immune system process GO:0002376 9.91 CD209 CD79A CLEC7A MBL2 SFTPD TLR2
4 response to lipopolysaccharide GO:0032496 9.9 ELANE IL10 TLR2 TLR4
5 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 9.85 IL10 IL4 IL5
6 cellular response to lipopolysaccharide GO:0071222 9.81 CSF2 IFNG IL10 TLR4
7 defense response to bacterium GO:0042742 9.8 ELANE IFNG IL10 MBL2 SFTPD TLR4
8 B cell differentiation GO:0030183 9.78 CD79A IL10 IL4
9 immune response GO:0006955 9.76 CCL17 CSF2 IFNG IL10 IL4 IL5
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.74 CSF2 IFNG IL4
11 positive regulation of tumor necrosis factor production GO:0032760 9.73 IFNG TLR2 TLR4
12 respiratory gaseous exchange GO:0007585 9.71 CFTR SFTPA2 SFTPD
13 toll-like receptor signaling pathway GO:0002224 9.71 SFTPA2 SFTPD TLR2 TLR4
14 positive regulation of B cell proliferation GO:0030890 9.7 IL4 IL5 TLR4
15 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.68 CSF2 IL4
16 positive regulation of chemokine production GO:0032722 9.68 TLR2 TLR4
17 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.67 TLR2 TLR4
18 microglial cell activation GO:0001774 9.67 IL4 TLR2
19 positive regulation of interleukin-12 production GO:0032735 9.67 IFNG TLR2 TLR4
20 negative regulation of nitric oxide biosynthetic process GO:0045019 9.66 IL10 IL4
21 response to molecule of bacterial origin GO:0002237 9.66 IL10 TLR2
22 I-kappaB phosphorylation GO:0007252 9.65 TLR2 TLR4
23 positive regulation of podosome assembly GO:0071803 9.65 CSF2 IL5
24 regulation of cytokine secretion GO:0050707 9.65 TLR2 TLR4
25 dendritic cell differentiation GO:0097028 9.64 CSF2 IL4
26 negative regulation of interleukin-17 production GO:0032700 9.64 IFNG TLR4
27 macrophage activation GO:0042116 9.63 CSF2 TLR4
28 positive regulation of chemokine biosynthetic process GO:0045080 9.63 IFNG IL4
29 positive regulation of interleukin-10 production GO:0032733 9.63 IL4 TLR2 TLR4
30 positive regulation of isotype switching to IgG isotypes GO:0048304 9.62 IFNG IL4
31 cellular response to lipoteichoic acid GO:0071223 9.62 TLR2 TLR4
32 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.61 ELANE TLR4
33 positive regulation of interleukin-12 biosynthetic process GO:0045084 9.59 IFNG TLR4
34 type 2 immune response GO:0042092 9.58 IL10 IL4
35 positive regulation of interleukin-23 production GO:0032747 9.58 CSF2 IFNG
36 defense response to protozoan GO:0042832 9.56 CLEC7A IFNG IL10 IL4
37 regulation of isotype switching GO:0045191 9.55 IL10 IL4
38 negative regulation of growth of symbiont in host GO:0044130 9.26 ELANE IFNG IL10 MBL2
39 positive regulation of MHC class II biosynthetic process GO:0045348 8.92 IFNG IL10 IL4 TLR4

Molecular functions related to Aspergillosis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.46 CSF2 IL10 IL4 IL5
2 mannose binding GO:0005537 9.37 CD209 MBL2
3 carbohydrate binding GO:0030246 9.35 CD209 CLEC7A MBL2 SFTPA2 SFTPD
4 signaling pattern recognition receptor activity GO:0008329 9.32 CLEC7A TLR2
5 lipopolysaccharide receptor activity GO:0001875 9.26 TLR2 TLR4
6 cytokine activity GO:0005125 9.1 CCL17 CSF2 IFNG IL10 IL4 IL5

Sources for Aspergillosis

9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
52 Novoseek
55 OMIM via Orphanet
59 PubMed
65 SNOMED-CT via Orphanet
68 Tocris
70 UMLS via Orphanet
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