MCID: ASP006
MIFTS: 73

Aspergillosis malady

Infectious diseases category

Summaries for Aspergillosis

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8Disease Ontology, 42NIH Rare Diseases, 33MedlinePlus, 3CDC, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Aspergillosis is an infection, growth, or allergic response caused by the aspergillus fungus. there are several different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. another kind of aspergillosis is invasive aspergillosis. this infection usually affects people with weakened immune systems due to cancer, aids, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. in this condition, the fungus invades and damages tissues in the body. invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. this type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. the fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. last updated: 10/2/2013

MalaCards: Aspergillosis, also known as aspergillosis, susceptibility to, is related to invasive aspergillosis and allergic bronchopulmonary aspergillosis. An important gene associated with Aspergillosis is CLEC7A (C-type lectin domain family 7, member A), and among its related pathways are Th17 Differentiation and Malaria. The drugs flucytosine and miconazole and the compounds mannan and cycloheximide have been mentioned in the context of this disorder. Affiliated tissues include lung, kidney and brain, and related mouse phenotypes are respiratory system and liver/biliary system.

Disease Ontology:8 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. it is a serious illnesses in people with a weakened immune system.

MedlinePlus:33 Aspergillosis is a disease caused by a fungus (or mold) called aspergillus. the fungus is very common in both indoors and outdoors. most people breathe in the spores of the fungus every day without being affected. but some people get the disease. it usually occurs in people with lung diseases or weakened immune systems. there are different kinds of aspergillosis. one kind is allergic bronchopulmonary aspergillosis (also called abpa). symptoms of abpa include wheezing and coughing. abpa can affect healthy people but it is most common in people with asthma or cystic fibrosis. another kind is invasive aspergillosis, which damages tissues in the body. it usually affects the lungs. sometimes it can also cause infection in other organs and spread throughout the body. it affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, ct scan of the lungs, and an examination of tissues for signs of the fungus. treatment is with antifungal drugs. if you have abpa, you may also take steroids. centers for disease control and prevention

CDC:3 Aspergillus is a common fungus that can be found in indoor and outdoor environments. Most people breathe in Aspergillus spores every day without being affected. Aspergillosis is a disease caused by this fungus and usually occurs in people with lung diseases or weakened immune systems. The spectrum of illness includes allergic reactions, lung infections, and infections in other organs.

Wikipedia:63 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Description from OMIM:46 614079

Aliases & Classifications for Aspergillosis

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8Disease Ontology, 42NIH Rare Diseases, 46OMIM, 10DISEASES, 44Novoseek, 48Orphanet, 33MedlinePlus, 60UMLS, 9diseasecard, 34MeSH, 56SNOMED-CT, 27ICD9CM, 39NCIt, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
aspergillosis:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

aspergillosis 8 42 46 10 44 48 33 60
aspergillosis, susceptibility to 9
infection due to aspergillus 8
aspergillosis, unspecified 8


External Ids:

Disease Ontology8 DOID:13564
MeSH34 D001228
ICD9CM27 117.3
NCIt39 C2886
OMIM46 614079
MESH via Orphanet35 D001228
SNOMED-CT via Orphanet57 65553006
ICD10 via Orphanet26 B44.0, B44.1, B44.2 B44.7, B44.8, B44.9, more
UMLS via Orphanet61 C0004030
ICD1025 B44, B44.9

Related Diseases for Aspergillosis

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17GeneCards, 18GeneDecks
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Diseases related to Aspergillosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 276)
idRelated DiseaseScoreTop Affiliating Genes
1invasive aspergillosis31.8TLR2, TLR4
2allergic bronchopulmonary aspergillosis31.7SFTPD, MBL2, IGHE, IL5, IL4, CFTR
3cystic fibrosis31.2SLPI, CFTR, MBL2, SFTPD, TLR4, CCL17
4asthma30.9IGHE, IL4, IL5
5allergic asthma30.9CCL17, TLR4, TLR2, SFTPD, IFNG, IGHE
6leukemia30.8TLR2, SLPI, TLR4, CFTR, IL4, MBL2
7chronic granulomatous disease30.7MT-CYB
8pneumonia30.6TLR4, TLR2, SFTPD, MBL2, MT-CYB, IL5
9candidiasis30.5IFNG
10tuberculosis30.5IL4, TLR1, SFTPD, IFNG, TLR2, MBL2
11influenza30.4CFTR, MBL2, MBL3P, IFNG, SFTPD
12pulmonary tuberculosis30.4TLR2, MBL2, IFNG, IL4
13neutropenia30.4MBL2
14bronchiectasis30.4TLR2, SLPI, CFTR, IGHE, MBL2
15hepatitis30.3TLR2
16rhinitis30.2IL4, IL5, IGHE
17sarcoidosis30.1IFNG, SFTPD, CCR4
18eosinophilia30.1CCR4, CCL17, IL4, IL5, IGHE, MBL2
19systemic lupus erythematosus30.1CCR4, TLR4, TLR2, IFNG, MBL2, IL4
20pulmonary fibrosis30.0CCR4, SFTPD, CCL17, CCL22
21eosinophilic pneumonia30.0IL5, CCL17, CCL22, IGHE
22allergic rhinitis30.0IGHE, IL4, IL5
23respiratory failure30.0CFTR, SFTPD
24pancreatitis30.0CFTR
25lung cancer30.0CCR4, CCL22, TLR4, SFTPD, SLPI, CFTR
26thyroiditis29.9MBL2
27churg-strauss syndrome29.9IL5
28meningitis29.9TLR2, MBL2
29arthritis29.9IFNG, IL4, TLR2, TLR4
30rheumatoid arthritis29.9CCR4, IL4, IFNG, SFTPD, TLR2, TLR4
31dermatitis29.9IL4, CCL22, CCR4, CCL17, IFNG, IGHE
32pulmonary sarcoidosis29.9SFTPD, CCR4, IFNG
33atopic dermatitis29.9IL5, IFNG, CCL22, CCR4, CCL17, IGHE
34psoriasis29.9CCR4, CCL22, CCL17, TLR2, IFNG, IL5
35adenocarcinoma29.7SFTPD
36bronchiolitis29.7TLR4, IGHE, IL5
37dermatomyositis29.7SFTPD
38acute pancreatitis29.7CFTR, TLR4
39pulmonary alveolar proteinosis29.7SFTPD
40pulmonary eosinophilia29.7SFTPD, IL5, IL4, IGHE
41liver cirrhosis29.7SLPI
42glomerulonephritis29.7MBL2
43leishmaniasis29.7IL4, IL5, IFNG, MT-CYB
44bronchitis29.7SLPI, CFTR, IL5, IGHE
45cutaneous t cell lymphoma29.7IL5, IFNG, CCL17, CCR4, IL4
46idiopathic pulmonary fibrosis29.7CCL17, CCR4, SFTPD, CCL22, IFNG
47hepatitis c29.7IL4, TLR2, TLR4, IFNG
48toxic shock syndrome29.7IFNG
49mastitis29.7TLR4, TLR2
50extrinsic allergic alveolitis29.7SFTPD, IGHE

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to aspergillosis

Clinical Features for Aspergillosis

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46OMIM
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Clinical features from OMIM:

614079

Drugs & Therapeutics for Aspergillosis

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Aspergillosis

Drug clinical trials:

Search ClinicalTrials for Aspergillosis

Search NIH Clinical Center for Aspergillosis

Search CenterWatch for Aspergillosis

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Aspergillosis

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Anatomical Context for Aspergillosis

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32MalaCards
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MalaCards organs/tissues related to Aspergillosis:

32
Lung, Kidney, Brain, Testes, Bone, Colon, Heart, Skin, Eye, Liver, Myeloid, T cells, Bone marrow, B cells, Thyroid, Whole blood, Prostate, Breast, Endothelial, Pituitary

Animal Models for Aspergillosis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Aspergillosis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538810.5SFTPD, CLEC7A
2MP:000537010.4CFTR, IL4, IL5, IFNG, TLR2, TLR4
3MP:000538710.3SLPI, CCR4, CCL17, TLR4, TLR2, TLR1
4MP:000539710.3CCR4, TLR4, TLR2, SFTPD, IFNG, MBL2
5MP:000537610.2IFNG, SFTPD, TLR2, TLR4, MBL2, IGHE
6MP:000538110.1TLR4, TLR2, IFNG, CLEC7A, IL5, IL4

Publications for Aspergillosis

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50PubMed
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Articles related to Aspergillosis:

(show top 50)    (show all 1466)
idTitleAuthorsYear
1
Isolated primary frontal sinus aspergillosis: role of endonasal endoscopic approach. (23388080)
2013
2
Microsatellite typing of Aspergillus flavus in patients with various clinical presentations of aspergillosis. (23336695)
2013
3
Comparison of serum and bronchoalveolar lavage galactomannan in diagnosing invasive aspergillosis in solid-organ transplant recipients. (22631066)
2012
4
An observational efficacy and safety analysis of the treatment of acute invasive aspergillosis using voriconazole. (21971820)
2012
5
Primary laryngeal aspergillosis related to oral sex? A case report and review of the literature. (24432202)
2012
6
New respirable and fast dissolving itraconazole dry powder composition for the treatment of invasive pulmonary aspergillosis. (22644590)
2012
7
Sinonasal aspergillosis in dogs: a review. (22788729)
2012
8
Pseudotumoral cutaneous aspergillosis in chronic granulomatous disease, report of a pediatric case. (22588549)
2012
9
Pulseless right upper limb: an unusual manifestation of invasive pulmonary aspergillosis in acute myeloid leukemia. (22715561)
2012
10
A pulmonary aspergillosis case with fatal course in a patient with SIRS clinic. (22091235)
2011
11
Eosinophilic pleural effusion complicating allergic bronchopulmonary aspergillosis. (21311176)
2011
12
Invasive pulmonary aspergillosis in a patient with seminomatous testicular cancer. (22126525)
2011
13
Evaluation of PCR on bronchoalveolar lavage fluid for diagnosis of invasive aspergillosis: a bivariate metaanalysis and systematic review. (22164295)
2011
14
Chronic necrotizing pulmonary aspergillosis. (22191319)
2011
15
The Y238X stop codon polymorphism in the human I^-glucan receptor dectin-1 and susceptibility to invasive aspergillosis. (21242599)
2011
16
Clinical relevance of peripheral blood eosinophil count in allergic bronchopulmonary aspergillosis. (22118718)
2011
17
Treatment strategies for invasive aspergillosis in neutropenic patients: voriconazole or liposomal amphotericin-B? (21482486)
2011
18
Geoclimatic factors and invasive aspergillosis after allogeneic hematopoietic stem cell transplantation: new perspectives for patient management? (20450415)
2010
19
Detection of Aspergillus DNA by a nested PCR assay is able to improve the diagnosis of invasive aspergillosis in paediatric patients. (19541789)
2009
20
Successful voriconazole treatment of invasive pulmonary aspergillosis in a patient with acute biphenotypic leukemia. (19727206)
2009
21
Resolution of corticosteroid-induced diabetes in allergic bronchopulmonary aspergillosis with omalizumab therapy: a novel approach. (19544162)
2009
22
Allergic bronchopulmonary aspergillosis: A review of 42 patients from a tertiary care center in India. (20440392)
2009
23
Diagnosing allergic bronchopulmonary aspergillosis in children with cystic fibrosis. (19203743)
2009
24
Molecular diagnosis of invasive aspergillosis in patients with hematologic malignancies - new answers to a diagnostic challenge? (23495815)
2008
25
Toll-like receptor 4 polymorphisms and aspergillosis in stem-cell transplantation. (18946062)
2008
26
Value of a single galactomannan determination (Platelia) for the diagnosis of invasive aspergillosis in non-hematological patients with clinical isolation of Aspergillus spp. (19180751)
2008
27
Development and optimization of quantitative PCR for the diagnosis of invasive aspergillosis with bronchoalveolar lavage fluid. (18510764)
2008
28
Invasive aspergillosis in the ICU: an emerging disease. (17646965)
2007
29
A systematic literature review on the diagnosis of invasive aspergillosis using polymerase chain reaction (PCR) from bronchoalveolar lavage clinical samples. (17604424)
2007
30
Non-decompensated cirrhosis as a risk factor for invasive aspergillosis: a case report and review of the immune dysfunction of cirrhosis. (18030192)
2007
31
Hospital-wide prospective mandatory surveillance of invasive aspergillosis in a French teaching hospital (2000-2002). (16257084)
2006
32
Pericardial and pleural diffusion of voriconazole during disseminated invasive aspergillosis: report of a case with successful outcome. (16532330)
2006
33
Use of galactomannan enzyme immunoassay for diagnosis of invasive aspergillosis in a tertiary-care center over a 12-month period. (16597909)
2006
34
Comparison of galactomannan detection, PCR-enzyme-linked immunosorbent assay, and real-time PCR for diagnosis of invasive aspergillosis in a neutropenic rat model and effect of caspofungin acetate. (16275948)
2005
35
A murine model of invasive aspergillosis: variable benefit of interferon-gamma administration under in vitro and in vivo conditions. (16433604)
2005
36
A case of allergic bronchopulmonary aspergillosis leading to pneumonia with unusual organisms. (16351036)
2005
37
Mucoid impaction: a localized form of allergic bronchopulmonary aspergillosis. (15510581)
2004
38
Azoles for allergic bronchopulmonary aspergillosis associated with asthma. (12917898)
2003
39
Cytokines and chemokines in allergic bronchopulmonary aspergillosis (ABPA) and experimental Aspergillus-induced allergic airway or asthmatic disease. (12456354)
2003
40
Allergic bronchopulmonary aspergillosis mimicking pulmonary tuberculosis. (11953782)
2002
41
Allergic bronchopulmonary aspergillosis in cystic fibrosis. (11307747)
2001
42
Prevalence of allergic bronchopulmonary aspergillosis in patients with bronchial asthma. (11316037)
2000
43
Conformational and linear B-cell epitopes of Asp f 2, a major allergen of Aspergillus fumigatus, bind differently to immunoglobulin E antibody in the sera of allergic bronchopulmonary aspergillosis patients. (10225885)
1999
44
Increased antigen-specific Th-2 response in allergic bronchopulmonary aspergillosis (ABPA) in patients with cystic fibrosis. (10088929)
1999
45
Pathogenesis of pulmonary aspergillosis. Granulocytopenia versus cyclosporine and methylprednisolone-induced immunosuppression. (7663787)
1995
46
Central nervous system aspergillosis following steroidal therapy for allergic bronchopulmonary aspergillosis. (8417908)
1993
47
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. (1653680)
1991
48
Allergic bronchopulmonary aspergillosis with adenopathy. (1883124)
1991
49
Development of allergic bronchopulmonary aspergillosis during treatment of severe asthma with systemic corticosteroids. (7462540)
1981
50
Leukopenia and therapy in leukemia as factors predisposing to fatal mycoses. Mucormycosis, aspergillosis, and cryptococcosis. (13864156)
1962

Genetic Variations for Aspergillosis

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Expression for genes affiliated with Aspergillosis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aspergillosis

Search GEO for disease gene expression data for Aspergillosis.

Pathways for genes affiliated with Aspergillosis

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52R&D Systems, 29KEGG, 12EMD Millipore, 51QIAGEN, 37NCBI BioSystems Database, 53Reactome, 4Cell Signaling Technology, 59Tocris Bioscience
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Pathways related to Aspergillosis according to GeneCards/GeneDecks:

(show all 35)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4TLR1
210.4TLR4, TLR2
310.4IL4, IL5
410.4TLR2, IL5, IL4
510.4TLR4, TLR2, IFNG
610.4IFNG, TLR2, TLR4
710.4IFNG, IL5, IL4
810.4IL4, IL5, IFNG
910.4IL4, IL5, IFNG
10
Hide members
10.4IL4, IL5, IFNG
1110.4IL4, IL5, IFNG
1210.4SFTPD, SFTPA2, SFTPA1
1310.4SFTPD, SFTPA2, SFTPA1
1410.4TLR1, TLR2, TLR4
1510.4TLR4, SFTPA1, SFTPA2
1610.4TLR4, TLR2, TLR1, CLEC7A
17
Hide members
10.4CLEC7A, TLR1, TLR2, TLR4
18
Hide members
10.4IL5, TLR1, TLR2, TLR4
1910.4TLR4, TLR2, TLR1, IFNG
20
Hide members
10.4TLR4, TLR2, TLR1, IFNG
21
Hide members
10.4IFNG, TLR1, TLR2, TLR4
2210.4CCL17, CCR4, CCL22
23
Hide members
10.4IL4, IL5, IGHE, IFNG
24
Hide members
10.4IL4, IL5, IFNG, TLR2, TLR4
2510.4CCL17, IGHE, IL5, IL4
2610.4TLR4, TLR2, TLR1, IFNG, CLEC7A
27
Hide members
10.4TLR4, TLR2, TLR1, IFNG, IL4
28
Hide members
10.4IL4, IL5, IFNG, CCL17, CCL22
2910.4TLR4, TLR2, TLR1, SFTPA1, IL4
30
Hide members
10.4CCL22, CCR4, CCL17, TLR4, IL5
3110.4TLR4, TLR2, SFTPA1, SFTPA2, SFTPD, MBL2
32
Hide members
10.4CCL22, CCR4, CCL17, IL5, IL4
33
Immune response Bacterial infections in normal airways
10.3CFTR, TLR4, TLR2, TLR1, SFTPA1, SFTPD
34
Hide members
10.3TLR4, TLR2, TLR1, IFNG, MBL2, IGHE
35
Hide members
10.3CCL22, CCR4, CCL17, TLR4, TLR2, TLR1

Compounds for genes affiliated with Aspergillosis

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44Novoseek, 28IUPHAR, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB, 2BitterDB
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Compounds related to Aspergillosis according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1mannan4410.8SFTPD, MBL3P, TLR2, MBL2, TLR4
2cycloheximide4410.8MT-CYB, TLR2
3polymyxin b4410.8TLR4, TLR2, MBL2, IL4, IFNG
4imiquimod44 28 59 1113.8TLR1, IFNG, TLR2, TLR4, IL5
5rantes4410.8TLR4, TLR2, IFNG, MBL2, IL4, SLPI
6il 104410.8CCL17, TLR4, TLR2, IL5, IL4, IFNG
7polyinosinic-polycytidylic acid4410.8IFNG, TLR2, TLR4, IL5, IL4
8budesonide44 49 1112.8IGHE, IL4, SFTPD, IFNG, IL5
9anti-fungal4410.8SLPI, IFNG, IL5, SFTPD, TLR2, TLR4
10zymosan4410.8CLEC7A, TLR4, TLR2, MBL2
11poly(i-c)4410.8TLR2, IFNG, IL5, TLR4, IL4
12lipoteichoic acid4410.8MBL2, TLR4, TLR2, TLR1, SLPI
13allergens4410.8TLR4, IL4, IL5, IGHE, IFNG, SFTPD
14pam3csk45910.8TLR2, TLR4, TLR1
15ccl344 2811.8CCR4, TLR4, CCL17, IFNG, CCL22, TLR2
16prednisolone44 28 1112.8IL5, SFTPD, MBL2, IGHE, CCR4
17poly(i:c)5910.8TLR4, TLR2, TLR1
18fluticasone propionate44 49 59 1113.8SLPI, IFNG, IGHE, IL5, IL4
19tacrolimus44 49 1112.8CCL22, IL5, CCL17, TLR4, IL4, TLR2
20cyclosporin a44 28 5912.8IFNG, CCL17, CCL22, SLPI, IGHE, CFTR
21mannose4410.8MBL2, CLEC7A, SFTPD, MBL3P, TLR2, TLR4
22omalizumab44 1111.8IGHE, IL5, IL4
23pam2csk45910.8TLR1, TLR2, TLR4
24tarc4410.8IL4, CCL22, CCL17, IFNG, CCR4, IGHE
25methacholine44 1111.8IL5, CCL22, IGHE, SLPI, IL4
26con a4410.7IFNG, IL5, IL4, MBL2
27histamine44 28 2412.7TLR4, CCL22, SLPI, TLR2, SFTPD, IL4
28hydrocortisone44 2 59 1113.7SLPI, IGHE
29vitamin d4410.7TLR2, TLR4, IL5, SLPI, MBL2, IGHE
30actinomycin d4410.7CFTR, SLPI, IL4, IGHE, IFNG, TLR2
31sb 20358044 5911.7CCL22, TLR4, IL5, IFNG, IL4, TLR2
32resiquimod44 5911.7TLR1, TLR2, TLR4
33cysteine4410.7SLPI, IL5, IL4, IFNG, TLR2, TLR4
34dexamethasone44 49 28 1113.7CCL17, SLPI, CFTR, IL4, IL5, CLEC7A
35polysaccharide4410.7IGHE, MBL2, MBL3P, SFTPD, TLR2, TLR4
36vegf4410.6TLR2, IL5, IGHE, MBL2, IL4, IFNG
37agarose4410.6TLR2, SFTPD, SLPI, MBL2, TLR4
38fibrinogen4410.6CCL22, SLPI, MBL2, TLR2, TLR4, CCL17
39carbohydrates4410.6CFTR, MBL2, SFTPD, TLR4, IGHE
40nitric oxide44 11 2412.6CCL17, SLPI, MT-CYB, MBL2, IFNG, SFTPD
41ovomucoid4410.6IL5, IGHE, IL4
42simvastatin44 49 59 28 11 2415.6TLR2, TLR4, CCR4, IL4, IFNG
43endotoxin4410.6SLPI
44infliximab44 49 1112.5IL4, IGHE, IFNG, TLR4
45peptidoglycan44 2811.5TLR1, MBL2, TLR2, TLR4
46calcium44 49 11 2413.4SLPI, MBL2, SFTPD, SFTPA2, SFTPA1, MT-CYB
47ivig4410.4IL4, IGHE, IFNG, IL5
48nedocromil sodium4410.3IGHE, IL5, IL4
49retinoic acid44 2411.3CFTR, IL5, IGHE, IFNG, TLR2, SLPI
50ccl444 2811.1CCL22, CCR4, CCL17, TLR2

GO Terms for genes affiliated with Aspergillosis

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16Gene Ontology
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Cellular components related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Toll-like receptor 1-Toll-like receptor 2 protein complexGO:03535410.4TLR1, TLR2
2extracellular spaceGO:00561510.4IL4, CCL22, CCL17, SFTPA1, SFTPA2, SFTPD
3external side of plasma membraneGO:00989710.4CCR4, TLR4, TLR2, IFNG, CLEC7A, IL4
4extracellular regionGO:00557610.2CCL22, CCL17, SFTPA1, SFTPA2, SFTPD, IFNG
5collagenGO:00558110.1SFTPA1, SFTPA2, SFTPD, MBL2

Biological processes related to Aspergillosis according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of MHC class II biosynthetic processGO:04534810.8TLR4, IFNG, IL4
2positive regulation of tumor necrosis factor productionGO:03276010.8TLR4, TLR2, IFNG, CLEC7A
3negative regulation of interleukin-17 productionGO:03270010.8IFNG, TLR2, TLR4
4positive regulation of tumor necrosis factor biosynthetic processGO:04253510.8TLR4, TLR2, TLR1
5positive regulation of phagocytosisGO:05076610.8SFTPD, MBL2, CLEC7A
6negative regulation of growth of symbiont in hostGO:04413010.8MBL2, IFNG, TLR2
7respiratory gaseous exchangeGO:00758510.8CFTR, SFTPD, SFTPA2, SFTPA1
8defense response to protozoanGO:04283210.8IFNG, CLEC7A, IL4
9positive regulation of interleukin-12 productionGO:03273510.8TLR4, TLR2, IFNG
10cell surface pattern recognition receptor signaling pathwayGO:00275210.8TLR2, CLEC7A
11cellular response to triacyl bacterial lipopeptideGO:07172710.8TLR2, TLR1
12detection of triacyl bacterial lipopeptideGO:04249510.8TLR2, TLR1
13positive regulation of nitric oxide biosynthetic processGO:04542910.7IFNG, TLR2, TLR4
14positive regulation of B cell proliferationGO:03089010.7TLR4, IL5, IL4
15inflammatory responseGO:00695410.7CCL22, CCR4, CCL17, TLR2, TLR1, CLEC7A
16innate immune responseGO:04508710.7TLR4, TLR2, TLR1, SFTPD, MBL2, IGHE
17positive regulation of macrophage cytokine productionGO:06090710.7TLR4, TLR2
18detection of diacyl bacterial lipopeptideGO:04249610.7TLR1, TLR2
19positive regulation of isotype switching to IgG isotypesGO:04830410.7IFNG, IL4
20chemotaxisGO:00693510.7CCL22, CCR4, CCL17, IL4
21cellular response to lipoteichoic acidGO:07122310.7TLR4, TLR2
22immune responseGO:00695510.7IL4, CCL22, CCR4, CCL17, TLR4, TLR2
23regulation of cytokine secretionGO:05070710.7TLR4, TLR1
24positive regulation of interleukin-6 biosynthetic processGO:04541010.6TLR1, IFNG
25positive regulation of interleukin-12 biosynthetic processGO:04508410.6TLR4, IFNG
26positive regulation of chemokine biosynthetic processGO:04508010.6IFNG, IL4
27macrophage activationGO:04211610.5TLR4, TLR1
28MyD88-dependent toll-like receptor signaling pathwayGO:00275510.5TLR1, TLR2, TLR4
29positive regulation of nitric-oxide synthase biosynthetic processGO:05177010.4TLR4, TLR2
30defense response to bacteriumGO:04274210.4MBL2, IFNG, TLR4
31I-kappaB phosphorylationGO:00725210.3TLR4, TLR2
32T-helper 1 type immune responseGO:04208810.1TLR1, TLR4

Molecular functions related to Aspergillosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1transmembrane signaling receptor activityGO:00488810.4TLR1, TLR2, TLR4
2carbohydrate bindingGO:03024610.4CLEC7A, SFTPD, SFTPA2, SFTPA1
3lipopolysaccharide receptor activityGO:00187510.3TLR4, TLR2
4signaling pattern recognition receptor activityGO:00832910.1CLEC7A, TLR2

Products for genes affiliated with Aspergillosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aspergillosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet