MCID: ASP006
MIFTS: 65

Aspergillosis

Categories: Genetic diseases, Rare diseases, Infectious diseases

Aliases & Classifications for Aspergillosis

MalaCards integrated aliases for Aspergillosis:

Name: Aspergillosis 53 12 72 49 55 51 40 3 41 14 69
Aspergillosis, Susceptibility to 53 28 13
Infection Due to Aspergillus 12

Characteristics:

Orphanet epidemiological data:

55
aspergillosis
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 55  
Rare infectious diseases


External Ids:

OMIM 53 614079
Disease Ontology 12 DOID:13564
ICD10 32 B44 B44.9
ICD9CM 34 117.3
MeSH 41 D001228
NCIt 46 C2886
Orphanet 55 ORPHA1163
MESH via Orphanet 42 D001228
UMLS via Orphanet 70 C0004030
ICD10 via Orphanet 33 B44.0 B44.1 B44.2 more
UMLS 69 C0004030

Summaries for Aspergillosis

NIH Rare Diseases : 49 Aspergillosis is an infection, growth, or allergic response caused by the Aspergillus fungus. There are several different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA), a condition where the fungus causes allergic respiratory symptoms similar to asthma, such as wheezing and coughing, but does not actually invade and destroy tissue. Another kind of aspergillosis is invasive aspergillosis. This infection usually affects people with weakened immune systems due to cancer, AIDS, leukemia, organ transplantation, chemotherapy, or other conditions or events that reduce the number of normal white blood cells. In this condition, the fungus invades and damages tissues in the body. Invasive aspergillosis most commonly affects the lungs, but can also cause infection in many other organs and can spread throughout the body (commonly affecting the kidneys and brain).Aspergilloma, a growth (fungus ball) that develops in an area of previous lung disease such as tuberculosis or lung abscess, is a third kind of aspergillosis. This type of aspergillosis is composed of a tangled mass of fungus fibers, blood clots, and white blood cells. The fungus ball gradually enlarges, destroying lung tissue in the process, but usually does not spread to other areas. Last updated: 10/2/2013

MalaCards based summary : Aspergillosis, also known as aspergillosis, susceptibility to, is related to allergic bronchopulmonary aspergillosis and invasive aspergillosis, and has symptoms including pruritus and fever. An important gene associated with Aspergillosis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Amphotericin B and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and kidney, and related phenotypes are hematopoietic system and homeostasis/metabolism

Disease Ontology : 12 An opportunistic mycosis that involves a spectrum of diseases of humans and animals caused by members of the genus Aspergillus infecting lungs, brain, kidney,heart, bone, eyes, sinuses, skin and gastrointestinal tract. It is a serious illnesses in people with a weakened immune system.

OMIM : 53 Aspergillus species are ubiquitous in nature and cause a wide spectrum of diseases, including saprophytic colonization of existing cavities (aspergilloma), allergic asthma, hypersensitivity pneumonitis, allergic bronchopulmonary aspergillosis, and disseminated disease associated with high mortality rates in patients with hematologic malignancies and recipients of solid organs and stem cell transplantations. Immunocompetent and nonatopic individuals are relatively resistant to infection, and disease occurs in the setting of host damage. Association of persistent inflammation with intractable infection is common in nonneutropenic patients after hematopoietic stem cell transplantation, as well as in allergic fungal diseases. The pathophysiology underlying Aspergillus infection highlights the bipolar nature of the inflammatory process in infection, in which early inflammation prevents or limits infection, but an uncontrolled response may oppose disease eradication (summary by Cunha et al., 2010). For information on familial occurrence of allergic bronchopulmonary aspergillosis, see 103920. (614079)

MedlinePlus : 40 Aspergillosis is a disease caused by a fungus (or mold) called Aspergillus. The fungus is very common in both indoors and outdoors. Most people breathe in the spores of the fungus every day without being affected. But some people get the disease. It usually occurs in people with lung diseases or weakened immune systems. There are different kinds of aspergillosis. One kind is allergic bronchopulmonary aspergillosis (also called ABPA). Symptoms of ABPA include wheezing and coughing. ABPA can affect healthy people but it is most common in people with asthma or cystic fibrosis. Another kind is invasive aspergillosis, which damages tissues in the body. It usually affects the lungs. Sometimes it can also cause infection in other organs and spread throughout the body. It affects people who have immune system problems, such as people who have had a transplant, are taking high doses of steroids, or getting chemotherapy for some cancers. Your doctor might do a variety of tests to make the diagnosis, including a chest x-ray, CT scan of the lungs, and an examination of tissues for signs of the fungus. Treatment is with antifungal drugs. If you have ABPA, you may also take steroids. Centers for Disease Control and Prevention

CDC : 3 Aspergillosis is an infection caused by Aspergillus, a common mold (a type of fungus) that lives indoors and outdoors. Most people breathe in Aspergillus spores every day without getting sick. However, people with weakened immune systems or lung diseases are at a higher risk of developing health problems due to Aspergillus. The types of health problems caused by Aspergillus include allergic reactions, lung infections, and infections in other organs.

Wikipedia : 72 Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus... more...

Related Diseases for Aspergillosis

Diseases in the Aspergillosis family:

Invasive Aspergillosis

Diseases related to Aspergillosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 420)
# Related Disease Score Top Affiliating Genes
1 allergic bronchopulmonary aspergillosis 32.6 CCL17 CFTR IL4 IL5 MBL2 SFTPA2
2 invasive aspergillosis 32.0 CD79A CLEC7A IFNG MBL2 SFTPD TLR2
3 hematopoietic stem cell transplantation 30.8 CLEC7A IFNG IL10
4 cystic fibrosis 30.2 CFTR ELANE MBL2 SFTPD TLR4
5 immune suppression 30.0 IFNG IL10
6 candidiasis 29.8 CD79A CLEC7A IFNG IL10
7 eosinophilic pneumonia 29.8 CCL17 IL5 SFTPD
8 ige responsiveness, atopic 29.8 IFNG IL10 IL4 IL5
9 cryptococcosis 29.8 IFNG IL4 MBL2 TLR9
10 wegener granulomatosis 29.8 ELANE IFNG IL10
11 rhinitis 29.8 IL4 IL5 TLR9
12 pneumocystosis 29.7 CD79A CLEC7A SFTPD
13 acute graft versus host disease 29.7 IFNG IL10 IL4
14 cough variant asthma 29.7 IL4 IL5
15 lepromatous leprosy 29.7 IFNG IL10 TLR2
16 respiratory failure 29.7 ELANE IL10 SFTPD
17 churg-strauss syndrome 29.6 CCL17 IL10 IL5
18 bronchiectasis 29.6 CFTR ELANE MBL2 TLR2
19 allergic rhinitis 29.5 IFNG IL10 IL4 IL5
20 cutaneous t cell lymphoma 29.5 CCL17 IFNG IL4
21 toxic shock syndrome 29.5 IFNG IL10 IL4 TLR4
22 pulmonary tuberculosis 29.4 IFNG IL10 IL4 MBL2 TLR2 TLR9
23 pulmonary eosinophilia 29.4 CCL17 IL4 IL5
24 hepatitis b 29.4 IFNG MBL2 TLR2 TLR4
25 dermatitis 29.4 CCL17 IFNG IL4 IL5
26 gastroenteritis 29.3 IFNG IL10 IL4 IL5
27 colitis 29.3 IFNG IL10 IL4 TLR4 TLR9
28 farmer's lung 29.3 CD79A ELANE
29 crohn's disease 29.2 IFNG IL10 TLR4 TLR9
30 meningitis 29.2 IFNG IL10 MBL2 TLR2 TLR9
31 chronic graft versus host disease 29.1 CD79A IFNG IL10
32 extrinsic allergic alveolitis 29.0 CD79A IL10 SFTPD
33 acquired immunodeficiency syndrome 29.0 CD79A IFNG IL10
34 interstitial lung disease 29.0 CCL17 IFNG IL10 IL4 SFTPD
35 allergic hypersensitivity disease 28.9 CCL17 IFNG IL10 IL4 IL5 TLR9
36 pneumonia 28.7 ELANE IL10 IL5 MBL2 SFTPD TLR2
37 rheumatoid arthritis 28.6 CD79A IFNG IL10 IL4 TLR2 TLR4
38 bronchiolitis 28.6 IFNG IL10 IL4 IL5 TLR4 TLR9
39 mycobacterium tuberculosis 1 28.6 CD209 IFNG IL10 IL4 MBL2 TLR2
40 paranasal sinus disease 28.5 CD79A IFNG IL10 IL4 IL5
41 psoriasis 28.4 CCL17 ELANE IFNG IL10 IL4 TLR9
42 lung disease 28.3 CFTR ELANE IL10 IL5 SFTPA2 SFTPD
43 dermatitis, atopic 28.3 CCL17 IFNG IL10 IL4 IL5 TLR2
44 leishmaniasis 28.2 IFNG IL10 IL4 IL5 TLR2 TLR4
45 bronchitis 28.2 CD79A CFTR ELANE IL5
46 common variable immunodeficiency 28.1 CD79A IFNG IL10 IL4 MBL2 TLR9
47 leprosy 3 28.1 CD209 CD79A IFNG IL10 IL4 TLR2
48 systemic lupus erythematosus 27.6 CD79A ELANE IFNG IL10 IL4 MBL2
49 asthma 27.6 CCL17 CD79A CFTR ELANE IFNG IL10
50 allergic bronchopulmonary aspergillosis, familial 12.1

Comorbidity relations with Aspergillosis via Phenotypic Disease Network (PDN):


Bronchiectasis Bronchitis
Deficiency Anemia Heart Disease
Postinflammatory Pulmonary Fibrosis Respiratory Failure

Graphical network of the top 20 diseases related to Aspergillosis:



Diseases related to Aspergillosis

Symptoms & Phenotypes for Aspergillosis

Clinical features from OMIM:

614079

UMLS symptoms related to Aspergillosis:


pruritus, fever

MGI Mouse Phenotypes related to Aspergillosis:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.28 IL10 CFTR IL4 CLEC7A ELANE IL5
2 homeostasis/metabolism MP:0005376 10.22 IL10 CFTR IL4 CLEC7A ELANE IL5
3 immune system MP:0005387 10.21 IL10 CFTR IL4 CLEC7A ELANE IL5
4 digestive/alimentary MP:0005381 10.11 IL10 CFTR IL4 CLEC7A IL5 IFNG
5 liver/biliary system MP:0005370 9.92 CD79A IL10 CFTR IL4 IFNG TLR2
6 neoplasm MP:0002006 9.8 CD79A IL10 ELANE IFNG TLR2 TLR4
7 normal MP:0002873 9.76 IFNG CD79A IL10 CFTR IL4 ELANE
8 renal/urinary system MP:0005367 9.5 IFNG CD79A IL4 MBL2 TLR2 TLR4
9 respiratory system MP:0005388 9.28 IL10 CFTR IL4 CLEC7A IL5 IFNG

Drugs & Therapeutics for Aspergillosis

Drugs for Aspergillosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 118)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4,Phase 2,Phase 3 1397-89-3 5280965 14956
2
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 22916-47-8 4189
3
Voriconazole Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137234-62-9 71616
4
Caspofungin Approved Phase 4,Phase 3,Phase 2,Phase 1 162808-62-0, 179463-17-3 2826718 468682
5
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
6
Itraconazole Approved, Investigational Phase 4,Phase 2,Phase 3,Early Phase 1 84625-61-6 55283
7
Anidulafungin Approved, Investigational Phase 4,Phase 3,Phase 2 166663-25-8 166548
8
Micafungin Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 235114-32-6 477468 3081921
9
Posaconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 171228-49-2 147912
10
Omalizumab Approved, Investigational Phase 4 242138-07-4
11
Mycophenolate mofetil Approved, Investigational Phase 4 128794-94-5 5281078
12
Mycophenolic acid Approved Phase 4 24280-93-1 446541
13
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
14 Anti-Bacterial Agents Phase 4,Phase 2,Phase 3
15 Antifungal Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
16 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
17 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1
18 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1
19 Liposomal amphotericin B Phase 4,Phase 2,Phase 3
20 Cytochrome P-450 CYP3A Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
21 Cytochrome P-450 Enzyme Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
22 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23 Hormones Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
24 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
25 Steroid Synthesis Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
26 Echinocandins Phase 4,Phase 3,Phase 2,Phase 1
27 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
28 Antitussive Agents Phase 4
29 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
30 Hydroxyitraconazole Phase 4,Phase 2,Phase 3,Early Phase 1
31 Anti-Allergic Agents Phase 4,Phase 2,Phase 3
32 Anti-Asthmatic Agents Phase 4,Phase 2,Phase 3
33 Antibodies Phase 4
34 Immunoglobulin E Phase 4
35 Immunoglobulins Phase 4
36 Respiratory System Agents Phase 4,Phase 2,Phase 3
37 Cytochrome P-450 CYP2C9 Inhibitors Phase 4,Phase 3,Phase 2,Phase 1
38 glucocorticoids Phase 4,Phase 2,Phase 3
39 Immunosuppressive Agents Phase 4,Phase 1
40
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
41
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
42
Midazolam Approved, Illicit Phase 2, Phase 3,Phase 1 59467-70-8 4192
43
Budesonide Approved Phase 2, Phase 3 51333-22-3 5281004 63006
44
deoxycholic acid Approved Phase 2, Phase 3 83-44-3 222528
45
Fluconazole Approved, Investigational Phase 3,Phase 1 86386-73-4 3365
46
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
47
Cholecalciferol Approved, Nutraceutical Phase 2, Phase 3, Phase 1 67-97-0 10883523 5280795 6221
48
Ergocalciferol Approved, Nutraceutical Phase 2, Phase 3,Phase 1 50-14-6 5280793
49
Vitamin D Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 1 1406-16-2
50 Methylprednisolone acetate Phase 2, Phase 3

Interventional clinical trials:

(show top 50) (show all 171)

# Name Status NCT ID Phase Drugs
1 Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation Unknown status NCT00986713 Phase 4 Amphotericin B
2 Voriconazole for IPA in Chinese Patients With COPD Unknown status NCT02234739 Phase 4 Voriconazole
3 Efficacy and Safety of Caspofungin for Invasive Pulmonary Aspergillosis Underlying Chronic Obstructive Pulmonary Disease Unknown status NCT01499433 Phase 4 caspofungin
4 Aspergillus PCR Early Detection in High Risk Oncohematological Patients Unknown status NCT01742026 Phase 4
5 Efficacy Of Itraconazole In Chronic Cavitary Pulmonary Aspergillosis Completed NCT01259336 Phase 4 Itraconazole;treatment in cavitary pulmonary aspergillosis
6 COMBISTRAT: AmBisome® in Combination With Caspofungin for the Treatment of Invasive Aspergillosis Completed NCT00334412 Phase 4 Ambisome;caspofungin
7 Voriconazole Prophylaxis Against Aspergillosis in Lung Transplant Recipients Completed NCT00177827 Phase 4
8 Acetato de Caspofungin (Cancidas®) in the Treatment of Fungal Infection Completed NCT00388167 Phase 4 Caspofungin
9 A Study To Assess The Anidulafungin And Voriconazole Concentration In Lung Following Intravenous Administration In Healthy Subjects Completed NCT00940017 Phase 4 anidulafungin and voriconazole
10 A Study of the Efficacy and Safety of Voriconazole for the Treatment of Fungal Infections Completed NCT00647907 Phase 4 Voriconazole
11 Pharmacokinetics of Micafungin in Patients of Intensive Care Units Completed NCT02164890 Phase 4
12 Posaconazole for the Prevention of Influenza-associated Aspergillosis in Critically Ill Patients Recruiting NCT03378479 Phase 4 SOC +Posaconazole 18 MG/ML (milligram/milliliter)
13 King's Invasive Aspergillosis Study II Not yet recruiting NCT02875743 Phase 4 Posaconazole
14 Study to Test the Combination of Voriconazole and Anidulafungin in Patients Who Have, or Are Thought to Have, Invasive Aspergillosis and Who Are Unable to Take a Common Antifungal Therapy (Polyene) Terminated NCT00620074 Phase 4 voriconazole;anidulafungin
15 Post Marketing Study to Evaluate the Efficacy and Safety of Micafungin Treatment on Invasive Aspergillosis Terminated NCT02646774 Phase 4 Micafungin
16 An Exploratory Study to Assess Multiple Doses of Omalizumab in Patients With Cystic Fibrosis Complicated by Acute Bronchopulmonary Aspergillosis (ABPA) Terminated NCT00787917 Phase 4 Omalizumab;Placebo;Itraconazole
17 Post Marketing Study to Evaluate the Safety and Efficacy of Micafungin Against Fungal Infections Caused by Candida Spp or Aspergillus Spp Terminated NCT02646800 Phase 4 Micafungin
18 Comparison of 2 Antifungal Treatment (Empirical Versus Pre-Empirical) Strategies in Prolonged Neutropenia Terminated NCT00190463 Phase 4 Amphotericin B
19 Evaluation of Antifungal Prophylaxis on Graft-versus-host Disease (GVHD) Patients Terminated NCT01282879 Phase 4 Itraconazole
20 A Study to Evaluate the Effectiveness of Voriconazole + Micafungin Versus Voriconazole Alone for Invasive Aspergillosis Withdrawn NCT00423163 Phase 4 micafungin;voriconazole
21 Posaconazole as Salvage Therapy for Aspergillus Pulmonary Infection. Withdrawn NCT02020213 Phase 4 Posaconazole
22 Efficacy, Safety and Pharmacokinetics of SPK-843 in the Treatment of Pulmonary Mycosis Unknown status NCT01125644 Phase 3 SPK-843
23 Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis Completed NCT00531479 Phase 3 voriconazole;anidulafungin;voriconazole
24 Voriconazole For Chronic Bronchopulmonary Aspergillosis Completed NCT00159822 Phase 2, Phase 3 Voriconazole
25 Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis Completed NCT00263315 Phase 2, Phase 3 nebulised liposomal amphotericin B
26 Trial on the Efficacy and Safety of Two Different Glucocorticoid Dose Regimens in Allergic Bronchopulmonary Aspergillosis Completed NCT00974766 Phase 2, Phase 3 Glucocorticoids;Glucocorticoids
27 A Safety & Effectiveness Study of Intravenous Anidulafungin With AmBisome® for Treatment of Invasive Aspergillosis (IA). Completed NCT00037206 Phase 2, Phase 3 Anidulafungin, VER002
28 A Multicentre Randomised Controlled Trial Comparing Two Strategies for the Diagnosis of Invasive Aspergillosis in High-risk Haematology Patients Completed NCT00163722 Phase 3
29 Voriconazole Versus Oral Steroids in Allergic Bronchopulmonary Aspergillosis Completed NCT01621321 Phase 2, Phase 3 Prednisolone;Voriconazole
30 Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi Completed NCT00634049 Phase 3 isavuconazole
31 A Randomized Controlled Trial of Inhaled Amphotericin B for Maintaining Remission in Allergic Bronchopulmonary Aspergillosis Completed NCT01857479 Phase 2, Phase 3 Inhaled budesonide;Inhaled amphotericin
32 Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis Completed NCT00001646 Phase 3 Voriconazole;Amphotericin B
33 Comparison of Voriconazole and Amphotericin B in Treating Patients With Aspergillosis Completed NCT00003031 Phase 3 amphotericin B deoxycholate;voriconazole
34 Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis Completed NCT00412893 Phase 3 Isavuconazole;Voriconazole
35 Assessing the Safety and Efficacy of MK-5592 (Posaconazole) in Japanese Participants With Fungal Infection (MK-5592-101) Completed NCT02180165 Phase 3 Posaconazole;Voriconazole
36 Study Safety/Efficacy of AmBisome Loading Dose Regimen Versus Standard AmBisome Regimen for Initial Treatment Completed NCT00158730 Phase 3 AmBisome
37 Monotherapy of Itraconazole Versus Prednisolone in Allergic Bronchopulmonary Aspergillosis Completed NCT01321827 Phase 2, Phase 3 Glucocorticoids;Itraconazole
38 A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED) Completed NCT00717860 Phase 3 caspofungin acetate;Comparator: Micafungin sodium
39 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001810 Phase 3 Voriconazole
40 Comparing the Effectiveness of Fluconazole and a New Medicine (FK463) in Preventing Fungal Infections in Bone Marrow Transplant Patients Completed NCT00001937 Phase 3 FK463;Fluconazole
41 Open Label Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P00041) Completed NCT00034658 Phase 3 Posaconazole
42 Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation Completed NCT00003883 Phase 3 fluconazole;itraconazole
43 Pharmacokinetic Profiles of Inhaled Lipid Complex Amphotericin B (Abelcet ®) Completed NCT00177684 Phase 3 Amphotericin B
44 Study of Posaconazole in the Treatment of Invasive Fungal Infections (Study P02095) Completed NCT00034632 Phase 3 Posaconazole oral suspension
45 An Open Label, Non-Comparative, Multicenter, Phase III Trial of the Efficacy, Safety and Toleration of Voriconazole in the Primary or Secondary Treatment of Invasive Fungal Infections Completed NCT00001757 Phase 3 Voriconazole
46 A Pharmacokinetic Study of JK1211(Itraconazole [Itrizole]) Oral Solution in Participants With Deep Mycosis and Those With Febrile Neutropenia Suspected of Fungal Infection Completed NCT00784368 Phase 3 ITCZ Oral Solution;ITCZ-IV
47 Voriconazole to Treat Fungal Infections Completed NCT00001940 Phase 3 Voriconazole
48 Safety and Effectiveness of Granulocyte Transfusions in Resolving Infection in People With Neutropenia (The RING Study) Completed NCT00627393 Phase 3 Standard antimicrobial therapy;G-CSF/dexamethasone
49 A Randomized Trial of Itraconazole in Acute Stages of Allergic Bronchopulmonary Aspergillosis Recruiting NCT02440009 Phase 2, Phase 3 Itraconazole;Glucocorticoids
50 A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069) Recruiting NCT01782131 Phase 3 Posaconazole;Voriconazole

Search NIH Clinical Center for Aspergillosis

Inferred drug relations via UMLS 69 / NDF-RT 47 :


Cochrane evidence based reviews: aspergillosis

Genetic Tests for Aspergillosis

Genetic tests related to Aspergillosis:

# Genetic test Affiliating Genes
1 Aspergillosis, Susceptibility to 28 CLEC7A

Anatomical Context for Aspergillosis

MalaCards organs/tissues related to Aspergillosis:

38
Lung, Testes, Kidney, Brain, Bone, Liver, Heart

Publications for Aspergillosis

Articles related to Aspergillosis:

(show top 50) (show all 1868)
# Title Authors Year
1
A Randomized Trial of Itraconazole vs Prednisolone in Acute-Stage Allergic Bronchopulmonary Aspergillosis Complicating Asthma. ( 29331473 )
2018
2
Predominance of non-fumigatus Aspergillus species among patients suspected to pulmonary aspergillosis in a tropical and subtropical region of the Middle East. ( 29410233 )
2018
3
Cost-effectiveness analysis of interventions for prevention of invasive aspergillosis among leukemia patients during hospital construction activities. ( 29105850 )
2018
4
Treatment of Sinonasal Aspergillosis by Debridement and Sinonasal Deposition Therapy with Clotrimazole Under Rhinoscopic Guidance. ( 29372867 )
2018
5
Subacute invasive aspergillosis associated with sorafenib therapy for hepatocellular carcinoma. ( 29370392 )
2018
6
X-linked agammaglobulinemia complicated with pulmonary aspergillosis. ( 29356289 )
2018
7
Low sensitivity of Lateral Flow Device-<i>Aspergillus</i>in patients with probable and proven aspergillosis: results from a multicentre evaluation. ( 29444833 )
2018
8
Early-onset invasive aspergillosis and other fungal infections in patients treated with ibrutinib. ( 29437588 )
2018
9
Vitamin D levels in asthmatic patients with and without allergic bronchopulmonary aspergillosis. ( 29314357 )
2018
10
Invasive pulmonary aspergillosis mimicking organizing pneumonia after mTOR inhibitor therapy: a case report. ( 29408183 )
2018
11
Predicting Invasive Aspergillosis in Hematology Patients by Combining Clinical and Genetic Risk Factors with Early Diagnostic Biomarkers. ( 29118175 )
2018
12
Applying host disease status biomarkers to therapeutic response monitoring in invasive aspergillosis patients. ( 29370415 )
2018
13
Improving the diagnosis of invasive aspergillosis by the detection of Aspergillus in broncho-alveolar lavage fluid: Comparison of non-culture-based assays. ( 29248586 )
2018
14
Epidemiology of invasive aspergillosis and triazole-resistant Aspergillus fumigatus in patients with haematological malignancies: a single-centre retrospective cohort study. ( 29394399 )
2018
15
Chitinase Induction Prior to Caspofungin Treatment of Experimental Invasive Aspergillosis in Neutropenic Rats Does Not Enhance Survival. ( 29084744 )
2018
16
Multiple small bowel perforations due to invasive aspergillosis in a patient with acute myeloid leukemia: case report and a systematic review of the literature. ( 29357049 )
2018
17
Murine model to follow hyphal development in invasive pulmonary aspergillosis. ( 29423632 )
2018
18
Invasive Aspergillosis with Pulmonary and Central Nervous System involvement during ibrutinib therapy for relapsed Chronic Lymphocytic Leukaemia, a case report. ( 29427802 )
2018
19
Cerebral aspergillosis: An emerging opportunistic infection in patients receiving ibrutinib for chronic lymphocytic leukemia? ( 29402474 )
2018
20
Outbreak of invasive aspergillosis in heart transplant recipients: The role of screening computed tomography scans in asymptomatic patients and universal antifungal prophylaxis. ( 29125713 )
2018
21
Receiver operating characteristic curve analysis of four Aspergillus-specific IgG assays for the diagnosis of chronic pulmonary aspergillosis. ( 29398462 )
2018
22
Clinical features of fatal severe fever with thrombocytopenia syndrome that is complicated by invasive pulmonary aspergillosis. ( 29428567 )
2018
23
Long-term follow up of invasive aspergillosis in allogeneic stem cell transplantation recipients and leukemia patients: Differences in risk factors and outcomes. ( 28689016 )
2017
24
Development of Aspergillosis in a cohort of non-neutropenic, non-transplant patients colonised by Aspergillus spp. ( 28056830 )
2017
25
Exposure-Response Relationships for Isavuconazole in Patients with Invasive Aspergillosis and Other Filamentous Fungi. ( 28923872 )
2017
26
Invasive aspergillosis in acute myeloid leukemia: Are we making progress in reducing mortality? ( 27915304 )
2017
27
Caspofungin Increases Fungal Chitin and Eosinophil and I^I' T Cell-Dependent Pathology in Invasive Aspergillosis. ( 28566368 )
2017
28
Evaluation of serum galactomannan enzyme immunoassay at two different cut-offs for the diagnosis of invasive aspergillosis in patients with febrile neutropenia. ( 28681812 )
2017
29
Multivariate Analysis As a Support for Diagnostic Flowcharts in Allergic Bronchopulmonary Aspergillosis: A Proof-of-Concept Study. ( 28878778 )
2017
30
Identifying rare diseases using electronic medical records: the example of allergic bronchopulmonary aspergillosis. ( 28370596 )
2017
31
IL-12 Influence mTOR to Modulate CD8(+) T Cells Differentiation through T-bet and Eomesodermin in Response to Invasive Pulmonary Aspergillosis. ( 28924369 )
2017
32
Emergence of Echinocandin Resistance due to a Point Mutation in the fks1 Gene of Aspergillus fumigatus in a Patient with Chronic Pulmonary Aspergillosis. ( 28923871 )
2017
33
Towards Translational ImmunoPET/MR Imaging of Invasive Pulmonary Aspergillosis: The Humanised Monoclonal Antibody JF5 Detects Aspergillus Lung Infections In Vivo. ( 28912884 )
2017
34
Cart before the horse: use of Aspergillus PCR to increase the diagnostic yield from BAL in hematological patients at risk of invasive aspergillosis. ( 28573907 )
2017
35
Novel cutting-edge metabolite-based diagnostic tools for aspergillosis. ( 28880911 )
2017
36
F508del CFTR gene mutation in patients with allergic bronchopulmonary aspergillosis. ( 29035608 )
2017
37
Antifungal prophylaxis with fluconazole in allogeneic stem cell transplantation recipients who had prior invasive aspergillosis with subsequent complete resolution by computed tomography. ( 29087731 )
2017
38
Atypical Presentation of Isolated Cerebral Aspergillosis in a Renal Allograft Recipient. ( 28892898 )
2017
39
Two cases of non-cystic fibrosis (CF) bronchiectasis with allergic bronchopulmonary aspergillosis. ( 28053855 )
2017
40
A suspected case of autoinduction of voriconazole metabolism in a patient with cerebral aspergillosis. ( 28932128 )
2017
41
Nosocomial legionellosis and invasive aspergillosis in a child with T-lymphoblastic leukemia. ( 28529020 )
2017
42
Triazole resistance is still not emerging in A fumigatus isolates causing invasive aspergillosis in Brazilian patients. ( 28893772 )
2017
43
Allergic bronchopulmonary aspergillosis in Japan: A nationwide survey. ( 28546015 )
2017
44
Inverted Mucoid Impaction Signal in Allergic Bronchopulmonary Aspergillosis: Are We Calling a Spade a Big Spoon? ( 29045221 )
2017
45
Increasing Total Serum IgE, Allergic Bronchopulmonary Aspergillosis, and Lung Function in Cystic Fibrosis. ( 28526275 )
2017
46
Efficacy and safety of micafungin for the treatment of patients with proven or probable invasive aspergillosis: A non-comparative, multicenter, phase IV, open-label study. ( 29384927 )
2017
47
Utility of the serum galactomannan assay for the diagnosis of invasive aspergillosis in children with acute lymphoblastic leukemia. ( 27815226 )
2017
48
Challenges and Solution of Invasive Aspergillosis in Non-neutropenic Patients: A Review. ( 29273978 )
2017
49
Invasive aspergillosis in a patient with end stage renal disease. ( 28761803 )
2017
50
Invasive Aspergillosis of the Abdominal Aorta with Multiple Peripheral Embolic Lesions. ( 28567096 )
2017

Variations for Aspergillosis

ClinVar genetic disease variations for Aspergillosis:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CLEC7A NM_197947.2(CLEC7A): c.714T> G (p.Tyr238Ter) single nucleotide variant risk factor rs16910526 GRCh37 Chromosome 12, 10271087: 10271087

Expression for Aspergillosis

Search GEO for disease gene expression data for Aspergillosis.

Pathways for Aspergillosis

Pathways related to Aspergillosis according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CD209 CD79A CLEC7A ELANE IFNG IL10
2
Show member pathways
13.36 CCL17 IL10 IL4 IL5 TLR2 TLR4
3
Show member pathways
13.15 CD79A IFNG IL4 TLR2 TLR4 TLR9
4
Show member pathways
12.94 CD209 CFTR CLEC7A TLR2 TLR4 TLR9
5
Show member pathways
12.77 CD209 IFNG IL4 TLR2 TLR4 TLR9
6
Show member pathways
12.55 IFNG IL10 IL4 IL5 TLR2 TLR4
7
Show member pathways
12.51 IFNG IL10 TLR2 TLR4 TLR9
8 12.51 CD79A IFNG IL10 IL4 TLR2 TLR9
9
Show member pathways
12.39 IFNG IL10 IL4 IL5
10
Show member pathways
12.34 IFNG IL10 IL4 IL5
11
Show member pathways
12.29 CCL17 CFTR IFNG IL4 IL5 TLR2
12
Show member pathways
12.23 IFNG IL10 IL4 TLR2 TLR4
13 12.17 IFNG TLR2 TLR4 TLR9
14
Show member pathways
12.14 IFNG IL10 IL4 IL5
15 12.05 CD209 CLEC7A IFNG IL10 TLR2 TLR4
16
Show member pathways
12.01 IL5 TLR2 TLR4 TLR9
17 11.95 IFNG IL4 TLR4
18
Show member pathways
11.93 IFNG IL10 TLR2 TLR4 TLR9
19
Show member pathways
11.92 CFTR IFNG IL4 SFTPD TLR2 TLR4
20 11.88 IFNG IL10 TLR2 TLR4
21 11.86 CD209 CD79A IFNG IL10 IL4 IL5
22 11.81 IFNG TLR2 TLR4
23 11.81 CLEC7A TLR2 TLR4 TLR9
24
Show member pathways
11.81 IFNG IL4 TLR2 TLR4 TLR9
25 11.78 IFNG IL10 IL4 IL5
26 11.77 IFNG IL4 IL5
27 11.74 CD209 IFNG IL10 TLR9
28
Show member pathways
11.73 IFNG IL4 IL5
29 11.73 IL10 SFTPA2 TLR4
30 11.68 CD209 CLEC7A MBL2 SFTPA2 SFTPD TLR2
31 11.65 CCL17 IL10 IL4 IL5
32 11.64 IL4 IL5 SFTPA2
33 11.51 IFNG TLR2 TLR4
34 11.49 IFNG IL10 TLR2 TLR4 TLR9
35 11.43 CCL17 IFNG IL10 IL4 IL5
36 11.36 IFNG IL10 TLR9
37 11.32 IFNG IL4 IL5
38 11.3 IFNG IL4 IL5
39 11.27 IFNG IL10 IL4 IL5
40 11.19 CCL17 IL10 IL4 IL5
41 11.15 IFNG IL10 IL4 IL5
42 10.92 IL10 IL4 IL5 TLR2 TLR4 TLR9
43 10.76 IL4 IL5

GO Terms for Aspergillosis

Cellular components related to Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CCL17 CD209 ELANE IFNG IL10 IL4
2 cell surface GO:0009986 9.63 CD209 CFTR ELANE MBL2 TLR2 TLR4
3 collagen trimer GO:0005581 9.5 MBL2 SFTPA2 SFTPD
4 extracellular space GO:0005615 9.32 CCL17 ELANE IFNG IL10 IL4 IL5
5 lamellar body GO:0042599 9.26 SFTPA2 SFTPD

Biological processes related to Aspergillosis according to GeneCards Suite gene sharing:

(show all 38)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 CCL17 IFNG IL10 IL4 IL5 TLR2
2 response to lipopolysaccharide GO:0032496 9.94 ELANE IL10 TLR2 TLR4
3 B cell differentiation GO:0030183 9.84 CD79A IL10 IL4
4 positive regulation of inflammatory response GO:0050729 9.83 TLR2 TLR4 TLR9
5 positive regulation of tumor necrosis factor production GO:0032760 9.81 TLR2 TLR4 TLR9
6 positive regulation of interleukin-6 production GO:0032755 9.8 TLR2 TLR4 TLR9
7 defense response to bacterium GO:0042742 9.8 ELANE IL10 MBL2 SFTPD TLR4 TLR9
8 inflammatory response GO:0006954 9.8 CCL17 CLEC7A IL10 IL5 TLR2 TLR4
9 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.77 TLR2 TLR4 TLR9
10 positive regulation of interleukin-8 production GO:0032757 9.77 TLR2 TLR4 TLR9
11 negative regulation of interleukin-6 production GO:0032715 9.76 IL10 TLR4 TLR9
12 positive regulation of interferon-beta production GO:0032728 9.75 TLR2 TLR4 TLR9
13 positive regulation of interleukin-10 production GO:0032733 9.74 TLR2 TLR4 TLR9
14 positive regulation of NF-kappaB import into nucleus GO:0042346 9.73 TLR2 TLR4 TLR9
15 positive regulation of B cell proliferation GO:0030890 9.73 IL4 IL5 TLR4 TLR9
16 positive regulation of chemokine production GO:0032722 9.72 TLR2 TLR4 TLR9
17 negative regulation of growth of symbiont in host GO:0044130 9.71 ELANE IL10 MBL2
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.7 TLR2 TLR4 TLR9
19 response to molecule of bacterial origin GO:0002237 9.69 IL10 TLR2 TLR9
20 positive regulation of macrophage activation GO:0043032 9.68 IL10 TLR4
21 negative regulation of interleukin-17 production GO:0032700 9.67 IFNG TLR4
22 cellular response to lipoteichoic acid GO:0071223 9.67 TLR2 TLR4
23 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.67 ELANE TLR4
24 I-kappaB phosphorylation GO:0007252 9.67 TLR2 TLR4 TLR9
25 positive regulation of interferon-beta biosynthetic process GO:0045359 9.65 TLR4 TLR9
26 type 2 immune response GO:0042092 9.65 IL10 IL4
27 regulation of cytokine secretion GO:0050707 9.65 TLR2 TLR4 TLR9
28 negative regulation of interleukin-8 production GO:0032717 9.64 IL10 TLR9
29 regulation of isotype switching GO:0045191 9.62 IL10 IL4
30 positive regulation of interleukin-18 production GO:0032741 9.62 TLR2 TLR9
31 tumor necrosis factor production GO:0032640 9.61 TLR2 TLR9
32 positive regulation of toll-like receptor signaling pathway GO:0034123 9.61 TLR2 TLR9
33 immune system process GO:0002376 9.56 CD209 CD79A CLEC7A MBL2 SFTPD TLR2
34 positive regulation of MHC class II biosynthetic process GO:0045348 9.54 IL10 IL4 TLR4
35 positive regulation of interleukin-12 production GO:0032735 9.46 IFNG TLR2 TLR4 TLR9
36 toll-like receptor signaling pathway GO:0002224 9.02 SFTPA2 SFTPD TLR2 TLR4 TLR9
37 regulation of receptor activity GO:0010469 10.05 CCL17 IFNG IL10 IL4 IL5
38 innate immune response GO:0045087 10 CD209 CLEC7A MBL2 SFTPD TLR2 TLR4

Molecular functions related to Aspergillosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 carbohydrate binding GO:0030246 9.35 CD209 CLEC7A MBL2 SFTPA2 SFTPD
2 mannose binding GO:0005537 9.32 CD209 MBL2
3 signaling pattern recognition receptor activity GO:0008329 9.26 CLEC7A TLR2
4 lipopolysaccharide receptor activity GO:0001875 9.16 TLR2 TLR4
5 cytokine activity GO:0005125 9.02 CCL17 IFNG IL10 IL4 IL5

Sources for Aspergillosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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