MCID: ASP004
MIFTS: 35

Asphyxia Neonatorum malady

Categories: Rare diseases, Fetal diseases, Respiratory diseases

Aliases & Classifications for Asphyxia Neonatorum

Aliases & Descriptions for Asphyxia Neonatorum:

Name: Asphyxia Neonatorum 38 12 50 42 14 69
Asphyxia, in Liveborn Infant 12
Hypoxia, in Liveborn Infant 69
Postnatal Asphyxia 12
Hypoxia Neonatorum 50
Asphyxia - Birth 12
Birth Asphyxia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11088
ICD10 33 P84 P21
ICD9CM 35 768.9
MeSH 42 D001238
UMLS 69 C0004045

Summaries for Asphyxia Neonatorum

MalaCards based summary : Asphyxia Neonatorum, also known as asphyxia, in liveborn infant, is related to birth defects and maturity-onset diabetes of the young, type 13. An important gene associated with Asphyxia Neonatorum is WIZ (Widely Interspaced Zinc Finger Motifs). The drugs Oxytocin and Vitamin C have been mentioned in the context of this disorder. Affiliated tissues include brain and heart.

Related Diseases for Asphyxia Neonatorum

Diseases related to Asphyxia Neonatorum via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 birth defects 10.0
2 maturity-onset diabetes of the young, type 13 10.0 ABCC8 SLC16A1
3 hepatitis 9.9
4 nasopharyngitis 9.9
5 pertussis 9.9
6 teratoma 9.9
7 nasopharyngeal teratoma 9.9
8 adams-oliver syndrome 2 9.8 MTM1 MTMR14 TTN
9 spindle cell sarcoma 9.8 MTM1 MTMR14 TTN
10 autoimmune hepatitis 8.5 ABCC8 GLS2 KCNC3 MGEA5 MTM1 MTMR14

Graphical network of the top 20 diseases related to Asphyxia Neonatorum:



Diseases related to Asphyxia Neonatorum

Symptoms & Phenotypes for Asphyxia Neonatorum

Drugs & Therapeutics for Asphyxia Neonatorum

Drugs for Asphyxia Neonatorum (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 89)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxytocin Approved, Vet_approved Phase 4 50-56-6 439302 53477758
2
Vitamin C Approved, Nutraceutical Phase 4 50-81-7 5785 54670067
3
Vitamin E Approved, Nutraceutical, Vet_approved Phase 4 59-02-9 14985
4 Antioxidants Phase 4,Phase 1,Phase 2
5 Micronutrients Phase 4,Phase 2
6 Protective Agents Phase 4,Phase 1,Phase 2
7 Tocopherols Phase 4
8 Tocotrienols Phase 4
9 Trace Elements Phase 4,Phase 2
10 Vitamins Phase 4,Phase 2
11 Oxytocics Phase 4,Phase 3
12 Tocopherol Nutraceutical Phase 4
13 Tocotrienol Nutraceutical Phase 4
14
Papaverine Approved Phase 2, Phase 3 61-25-6, 58-74-2 4680
15
Magnesium Sulfate Approved, Vet_approved Phase 3 7487-88-9 24083
16
Progesterone Approved, Vet_approved Phase 2, Phase 3 57-83-0 5994
17
Dinoprostone Approved Phase 3 363-24-6 5280360
18 Analgesics Phase 2, Phase 3
19 Autonomic Agents Phase 2, Phase 3,Phase 1
20 Drotaverin Phase 2, Phase 3
21 Parasympatholytics Phase 2, Phase 3
22 Peripheral Nervous System Agents Phase 2, Phase 3, Phase 1
23 Phosphodiesterase Inhibitors Phase 2, Phase 3,Phase 1
24 Vasodilator Agents Phase 2, Phase 3,Phase 1
25 Epoetin alfa Phase 2, Phase 3, Phase 1 113427-24-0
26 Hematinics Phase 2, Phase 3, Phase 1
27 Anesthetics Phase 3,Phase 1,Phase 2
28 Anti-Arrhythmia Agents Phase 3
29 Anticonvulsants Phase 3,Phase 2
30 calcium channel blockers Phase 3
31 Calcium, Dietary Phase 3
32 Central Nervous System Depressants Phase 3,Phase 1,Phase 2
33 Tocolytic Agents Phase 3
34 11-hydroxyprogesterone Phase 2, Phase 3
35 17-alpha-hydroxy-progesterone caproate Phase 2, Phase 3
36 Estrogen Antagonists Phase 2, Phase 3
37 Estrogens Phase 2, Phase 3
38 Hormone Antagonists Phase 2, Phase 3
39 Hormones Phase 2, Phase 3
40 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
41 Progestins Phase 2, Phase 3
42 Caproate Nutraceutical Phase 2, Phase 3
43
Nitric Oxide Approved Phase 1, Phase 2 10102-43-9 145068
44
Topiramate Approved Phase 2 97240-79-4 5284627
45
Darbepoetin alfa Approved, Investigational Phase 1, Phase 2 11096-26-7, 209810-58-2
46
Melatonin Approved, Nutraceutical, Vet_approved Phase 1, Phase 2 73-31-4 896
47
Biotin Approved, Nutraceutical Phase 2 58-85-5 171548
48
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
49 Anti-Asthmatic Agents Phase 1, Phase 2
50 Bronchodilator Agents Phase 1, Phase 2

Interventional clinical trials:

(show top 50) (show all 65)
id Name Status NCT ID Phase
1 Single High Dose Vitamin C, E in Severe Birth Asphyxia Completed NCT01743742 Phase 4
2 BRAIN - Home Intervention Trial Completed NCT00639184 Phase 4
3 Continued Versus Discontinued Oxytocin Stimulation of Labour Recruiting NCT02553226 Phase 4
4 Oxygen Toxicity in the Resuscitation in Extremely Premature Infants Completed NCT00494702 Phase 3
5 Neonatal Resuscitation in Zambia Completed NCT00097097 Phase 3
6 Whole-Body Cooling for Birth Asphyxia in Term Infants Completed NCT00005772 Phase 3
7 Drotaverine to Shorten the Length of Labor Completed NCT01639027 Phase 2, Phase 3
8 Neuroprotective Role of Erythropoietin in Perinatal Asphyxia Completed NCT02002039 Phase 2, Phase 3
9 Magnesium Sulphate in Perinatal Asphyxia Completed NCT00553072 Phase 3
10 17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies Completed NCT00163020 Phase 2, Phase 3
11 High-dose Erythropoietin for Asphyxia and Encephalopathy Recruiting NCT02811263 Phase 3
12 Mechanical cervicAl ripeninG for Women With PrOlongedPregnancies Recruiting NCT02907060 Phase 3
13 Erythropoietin in Infants With Hypoxic Ischemic Encephalopathy (HIE) Completed NCT00945789 Phase 1, Phase 2
14 Safety and Efficacy of Topiramate in Neonates With Hypoxic Ischemic Encephalopathy Treated With Hypothermia Completed NCT01241019 Phase 2
15 Systemic Hypothermia Improves Outcome of Hypoxic-Ischemic Encephalopathy Completed NCT00817401 Phase 1, Phase 2
16 Darbe Administration in Newborns Undergoing Cooling for Encephalopathy Completed NCT01471015 Phase 1, Phase 2
17 Melatonin for Neuroprotection Following Perinatal Asphyxia Completed NCT02071160 Phase 1, Phase 2
18 Use of Omega-3 Fatty Acids for Perinatal Depression Completed NCT00402389 Phase 2
19 Intermittent Auscultation Using Handheld Doppler: a Randomized Controlled Trial Comparing Perinatal Outcomes in Uganda Completed NCT02273037 Phase 2
20 Neuroprotective Effects of Hypothermia Combined With Inhaled Xenon Following Perinatal Asphyxia Completed NCT00934700 Phase 1, Phase 2
21 Neonatal Erythropoietin And Therapeutic Hypothermia Outcomes in Newborn Brain Injury (NEATO) Active, not recruiting NCT01913340 Phase 1, Phase 2
22 A Study of 2-Iminobiotin in Neonates With Perinatal Asphyxia Terminated NCT01626924 Phase 2
23 Therapeutic Hypothermia for Severe Acute Pancreatitis Withdrawn NCT01794858 Phase 2
24 Neonatal Erythropoietin in Asphyxiated Term Newborns Completed NCT00719407 Phase 1
25 Sober Network IPT for Perinatal Women With Comorbid Substance Use and Depression Completed NCT01550913 Phase 1
26 Sildenafil Administration to Treat Neonatal Encephalopathy Recruiting NCT02812433 Phase 1
27 S100B as a Marker of Brain Injury of Preterm Infants Unknown status NCT02082535
28 Apgar-Score in Asphyxiated Infants Under Resuscitation Unknown status NCT01193751
29 Characterization of the Cord Blood Stem Cell in Situation of Neonatal Asphyxia Completed NCT01284673
30 Naushero Feroze Neonatal Survival Project Completed NCT01350765
31 First Breath: Neonatal Resuscitation in Developing Countries Completed NCT00136708
32 Resident Training Enhanced by New Innovations: Teleintubation Completed NCT02572427
33 Randomized Clinical Trial Assessing Laryngeal Mask Airway Versus Face-mask Ventilation in Neonatal Resuscitation Completed NCT02042118
34 Intraosseous Infusion for Neonatal Asphyxiated Resuscitation Completed NCT01866358
35 Early or Late Cord Clamping in the Depressed Neonate Completed NCT02727517
36 Home Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT Completed NCT02473796
37 Infant Special Program for In Hospital Resuscitation Education in the Delivery Room Completed NCT02347241
38 TOBY (TOtal Body hYpothermia): a Study of Treatment for Perinatal Asphyxia Completed NCT00147030
39 Post Term Pregnancy - Induction of Labor or Monitoring of Pregnancy Completed NCT00385229
40 Measurements of Colloid Osmotic Pressure in Interstitial Fluid and Plasma in Healthy and Sick Children Completed NCT01044940
41 Routine Ultrasound Screening in the Third Trimester Completed NCT01594463
42 Moyo; strap-on Fetal Heart Rate Monitoring in a Rural Setting Completed NCT02790814
43 Best Partograph Action Line to Prevent Prolonged Labour Completed NCT02911272
44 Lufwanyama Neonatal Survival Project Completed NCT00518856
45 Medicaid Enhanced Prenatal/Postnatal Services Using a Nurse-Community Health Worker Team Completed NCT00536159
46 A Skills and Drills Intervention for Emergency Obstetrics and Neonatal Care at First Referral Units of North Karnataka Completed NCT01865656
47 CoolCap Followup Study-Coordination of Participating Centers Completed NCT00581581
48 Improved Accessibility of EmONC Services for Maternal and Newborn Health: a Community Based Project Completed NCT01751945
49 Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan Completed NCT02797353
50 CoolCap Trial, Treatment of Perinatal Hypoxic-Ischemic Encephalopathy Completed NCT00383305

Search NIH Clinical Center for Asphyxia Neonatorum

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Asphyxia Neonatorum cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asphyxia Neonatorum:
Cord blood-derived hematopoietic stem cells for treatment of oxygen deprivation in newborns
Embryonic/Adult Cultured Cells Related to Asphyxia Neonatorum:
Umbilical cord blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: asphyxia neonatorum

Genetic Tests for Asphyxia Neonatorum

Anatomical Context for Asphyxia Neonatorum

MalaCards organs/tissues related to Asphyxia Neonatorum:

39
Brain, Heart

Publications for Asphyxia Neonatorum

Articles related to Asphyxia Neonatorum:

(show top 50) (show all 84)
id Title Authors Year
1
Human recombinant erythropoietin in asphyxia neonatorum: pilot trial. ( 20385632 )
2010
2
Defending a neurologic birth injury. Asphyxia neonatorum redux. ( 19499449 )
2009
3
Is it time to revisit a role for antithrombotic therapy in asphyxia neonatorum? ( 15080111 )
2004
4
Renal insult in asphyxia neonatorum. ( 11042710 )
2000
5
Hepatic profile in asphyxia neonatorum. ( 9567557 )
1997
6
Maternal factors contributing to asphyxia neonatorum. ( 8816028 )
1996
7
Influence of maternal nutritional status on mode of delivery and asphyxia neonatorum. ( 1398866 )
1992
8
Myocardial changes in neonates dying of asphyxia neonatorum. ( 1344220 )
1992
9
Foetal co-relates and mode of delivery in asphyxia neonatorum. ( 1937632 )
1991
10
ECG changes in asphyxia neonatorum. ( 2081640 )
1990
11
Asphyxia neonatorum. ( 3711811 )
1986
12
Definition and grading of asphyxia neonatorum. ( 3775608 )
1986
13
Myocardial ischaemia in asphyxia neonatorum. Electrocardiographic, enzymatic and histological correlations. ( 4024929 )
1985
14
Management of asphyxia neonatorum. ( 1193711 )
1975
15
Asphyxia neonatorum: a clinical evaluation of 60 affected infants. ( 1193708 )
1975
16
Asphyxia neonatorum--neurological status at one year follow-up. ( 4473837 )
1974
17
Asphyxia neonatorum--assessment of the infant at birth. ( 4473836 )
1974
18
Asphyxia neonatorum--incidence in Cape Town. ( 4428302 )
1974
19
Letter: Asphyxia neonatorum. ( 4475487 )
1974
20
Neonatal complications and conditions associated with asphyxia neonatorum. ( 4432179 )
1974
21
Asphyxia neonatorum. ( 4799713 )
1973
22
Asphyxia neonatorum caused by foaming. ( 4112571 )
1972
23
Asphyxia neonatorum. ( 5529468 )
1970
24
Hyponatremia following asphyxia neonatorum. ( 5448486 )
1970
25
Memory deficit in monkeys brain damaged by asphyxia neonatorum. ( 4979089 )
1969
26
Asphyxia neonatorum. ( 5587613 )
1967
27
Controlled trials of hyperbaric oxygen and tracheal intubation in asphyxia neonatorum. ( 4160515 )
1966
28
The use of hyperbaric oxygen in asphyxia neonatorum and the respiratory distress syndrome. ( 6003308 )
1966
29
On the influence of abnormal parturition, difficult labours, premature birth, and asphyxia neonatorum, on the mental and physical condition of the child, especially in relation to deformities. ( 5950310 )
1966
30
TREATMENT OF ASPHYXIA NEONATORUM BY HYPERBARIC OXYGENATION. ( 14252020 )
1965
31
ASPHYXIA NEONATORUM. ( 14116230 )
1964
32
HYPOTHERMIA IN THE TREATMENT OF ASPHYXIA NEONATORUM. ( 14136494 )
1964
33
ASPHYXIA NEONATORUM. ( 14044048 )
1963
34
Structural and functional sequelae of asphyxia neonatorum in monkeys (Macaca mulatta). ( 14007461 )
1962
35
Hypothermia and transfusion with oxygenated blood in the treatment of asphyxia neonatorum. ( 14000132 )
1962
36
Effects of asphyxia neonatorum on behavior in the Rhesus monkey. ( 14497712 )
1961
37
The weight of the heart of mature infants after asphyxia neonatorum. ( 13689151 )
1961
38
Maternal and obstetric factors in asphyxia neonatorum with a preliminary report on a possible association with ABO blood groups. ( 13683009 )
1960
39
Brain damage in the monkey, macaca mulatta, by asphyxia neonatorum. ( 13663899 )
1959
40
An electronic resuscitator for possible use in asphyxia neonatorum. ( 13616412 )
1958
41
Asphyxia neonatorum. ( 13479645 )
1957
42
Neurological and psychological deficits from asphyxia neonatorum. ( 13441865 )
1957
43
Causation and treatment of asphyxia neonatorum. ( 13306743 )
1956
44
Management of asphyxia neonatorum. ( 13359430 )
1956
45
Asphyxia neonatorum. ( 13310418 )
1956
46
Asphyxia neonatorum: its clinical features and treatment. ( 13292258 )
1955
47
Pathological anatomy of asphyxia neonatorum. ( 13292256 )
1955
48
An experimental study of the human fetus with special reference to asphyxia neonatorum. ( 13292259 )
1955
49
Late result of prolonged endotracheal insufflation in asphyxia neonatorum. ( 14389722 )
1955
50
Asphyxia neonatorum due to a nasopharyngeal teratoma. ( 13159371 )
1954

Variations for Asphyxia Neonatorum

Expression for Asphyxia Neonatorum

Search GEO for disease gene expression data for Asphyxia Neonatorum.

Pathways for Asphyxia Neonatorum

GO Terms for Asphyxia Neonatorum

Cellular components related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 voltage-gated potassium channel complex GO:0008076 9.16 ABCC8 KCNC3
2 I band GO:0031674 8.96 MTM1 TTN
3 ruffle GO:0001726 8.8 MTM1 MTMR14 S100B

Biological processes related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol biosynthetic process GO:0006661 8.96 MTM1 MTMR14
2 regulation of insulin secretion GO:0050796 8.62 ABCC8 SLC16A1

Molecular functions related to Asphyxia Neonatorum according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 potassium channel activity GO:0005267 9.16 ABCC8 KCNC3
2 phosphatidylinositol-3-phosphatase activity GO:0004438 8.96 MTM1 MTMR14
3 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity GO:0052629 8.62 MTM1 MTMR14

Sources for Asphyxia Neonatorum

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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