MCID: ASP007
MIFTS: 43

Aspiration Pneumonia malady

Summaries for Aspiration Pneumonia

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. it is seen in individuals with dysphagia and gastric dysmotility. the disease has symptom tachypnea and has symptom cough.

MalaCards: Aspiration Pneumonia, also known as pneumonia aspiration, is related to bacteremia and sepsis, and has symptoms including tachypneaand cough. An important gene associated with Aspiration Pneumonia is ELANE (elastase, neutrophil expressed), and among its related pathways is Selected targets of C/EBPbeta. The compounds ulinastatin and sivelestat sodium hydrate have been mentioned in the context of this disorder. Affiliated tissues include brain, heart and colon.

Wikipedia:64 Aspiration pneumonia is bronchopneumonia that develops due to the entrance of foreign materials into the... more...

Aliases & Classifications for Aspiration Pneumonia

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Aliases & Descriptions:

aspiration pneumonia 8 10 61
pneumonia aspiration 45


External Ids:

Disease Ontology8 DOID:0050152
NCIt40 C34932
SNOMED-CT57 47839005, 422588002
MeSH35 D011015

Related Diseases for Aspiration Pneumonia

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Aspiration Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1bacteremia30.3LACTB, CRP
2sepsis30.3CRP, IL8, LACTB, ELANE
3bronchiolitis30.0IL8
4acute pancreatitis30.0ELANE, IL8, CRP
5septic shock30.0ELANE, LACTB, IL8, CRP
6dysphagia10.6
7anaerobic pneumonia10.4
8lipid pneumonia10.4
9achalasia10.3
10bronchiectasis10.2
11megaesophagus10.2
12diffuse idiopathic skeletal hyperostosis10.2
13aspiration pneumonitis10.2
14tracheoesophageal fistula10.2
15stroke, ischemic10.0
16burns10.0
17bronchiolitis obliterans10.0
18acute chest syndrome10.0
19pulmonary edema10.0
20digeorge syndrome10.0
21kennedy's disease10.0
22gastric ulcer10.0
23gastroesophageal reflux disease10.0
24esophageal atresia10.0
25adult syndrome10.0
26bipolar disorder10.0
27developmental disabilities10.0
28x-linked spinal-bulbar muscle atrophy10.0
29candida glabrata10.0
30klebsiella10.0
31oral cancer10.0
32alzheimer disease risk factor10.0
33guillain-barr� syndrome10.0
34myotonia10.0
35swallowing disorders10.0
36erythrocytosis10.0
37sinusitis10.0LACTB
38endophthalmitis10.0LACTB
39otitis media10.0LACTB
40wegener's granulomatosis10.0ELANE
41gingivitis10.0ELANE
42alpha 1-antitrypsin deficiency10.0ELANE
43pancreas disease10.0ELANE
44gastroenteritis10.0LACTB
45glomerulonephritis10.0ELANE
46pulmonary disease, chronic obstructive10.0CRP
47acute pyelonephritis10.0CRP
48capillary leak syndrome10.0ELANE
49carotid stenosis10.0CRP
50ulcerative colitis10.0CRP

Graphical network of the top 20 diseases related to Aspiration Pneumonia:



Diseases related to aspiration pneumonia

Clinical Features for Aspiration Pneumonia

Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • tachypnea
  • cough

Drugs & Therapeutics for Aspiration Pneumonia

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Aspiration Pneumonia

Drug clinical trials:

Search ClinicalTrials for Aspiration Pneumonia

Search NIH Clinical Center for Aspiration Pneumonia

Search CenterWatch for Aspiration Pneumonia

Genetic Tests for Aspiration Pneumonia

Anatomical Context for Aspiration Pneumonia

Sources:
33MalaCards
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MalaCards organs/tissues related to Aspiration Pneumonia:

33
Brain, Heart, Colon, Lung, Tongue

Animal Models for Aspiration Pneumonia or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Aspiration Pneumonia

Sources:
51PubMed
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Articles related to Aspiration Pneumonia:

(show top 50)    (show all 408)
idTitleAuthorsYear
1
Aspiration pneumonia and death in Huntington's disease. (22307361)
2012
2
Risk factors for aspiration pneumonia in frail older people: a systematic literature review. (21450240)
2011
3
Severe hypoxaemia due to methaemoglobinaemia and aspiration pneumonia. (22679183)
2011
4
A patient with severe emphysema and aspiration pneumonia. (20802009)
2011
5
The effect of hyperbaric oxygen treatment on aspiration pneumonia. (21656021)
2011
6
New aspirations: the debate on aspiration pneumonia treatment guidelines. (21978335)
2011
7
Sensory stimulation to improve swallowing reflex and prevent aspiration pneumonia in elderly dysphagic people. (21258172)
2011
8
The outcome and prognostic factors in patients with aspiration pneumonia during concurrent chemoradiotherapy for head and neck cancer. (20109165)
2010
9
Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia. (20102390)
2010
10
Predictors of aspiration pneumonia following radiotherapy for head and neck cancer. (19999368)
2009
11
Limitations in using aspiration pneumonia as a quality measure. (19877817)
2009
12
Reducing the risk of aspiration pneumonia among elderly patients in long-term care facilities through oral health interventions. (18261707)
2008
13
Impaired urge-to-cough in elderly patients with aspiration pneumonia. (19019213)
2008
14
Incidence of aspiration pneumonia in ALS in Olmsted County, MN. (17453635)
2007
15
Squalene aspiration pneumonia in children: radiographic and CT findings as the first clue to diagnosis. (15806404)
2005
16
Aspiration pneumonia. (14989729)
2004
17
Ampicillin + sulbactam vs clindamycin +/- cephalosporin for the treatment of aspiration pneumonia and primary lung abscess. (14759242)
2004
18
The nasogastric feeding tube as a risk factor for aspiration and aspiration pneumonia. (12690267)
2003
19
Aspiration pneumonia and dysphagia in the elderly. (12853541)
2003
20
Introduction of simple swallowing ability test for prevention of aspiration pneumonia in the elderly and investigation of factors of swallowing disorders. (11828754)
2002
21
Methods for decreasing risk of aspiration pneumonia in critically ill patients. (12405624)
2002
22
Outcome of acid ingestion related aspiration pneumonia. (11932160)
2002
23
Predictors of aspiration pneumonia in nursing home residents. (12355145)
2002
24
Incidence of aspiration pneumonia in intubated patients receiving activated charcoal. (10195487)
1999
25
The value of the lipid-laden macrophage index in the assessment of aspiration pneumonia. (9404586)
1997
26
Aspiration pneumonia in a mentally handicapped patient due to a foreign body impacted in the pharynx: a near fatal outcome. (8832357)
1996
27
Treatment of aspiration pneumonia with low-dose methylprednisolone and antibiotics]. (7699968)
1995
28
The cytologic evaluation of lipid-laden alveolar macrophages as an indicator of aspiration pneumonia in young children. (7887776)
1995
29
Sputum substance P in aspiration pneumonia. (7539090)
1995
30
Is penicillin G an adequate initial treatment for aspiration pneumonia? A prospective evaluation using a protected specimen brush and quantitative cultures. (8408937)
1993
31
Aspiration pneumonia. (1431490)
1992
32
Does gastrostomy and fundoplication prevent aspiration pneumonia in mentally retarded persons? (2502160)
1989
33
Aspiration pneumonia in an infant with pharyngonasal reflux and left-sided vocal cord paralysis. (3798192)
1987
34
Aspiration pneumonia: a review. (3513497)
1986
35
Aspiration pneumonia caused by fibrous material in rats. (3803436)
1986
36
Aspiration pneumonia and complications of inhalation of smoke and toxic gases. (3878028)
1985
37
Aspiration pneumonia after brain surgery. (6800924)
1981
38
Percutaneous transtracheal aspiration in the diagnosis and treatment of aspiration pneumonia in children. (6989969)
1980
39
Aspiration pneumonia: a ten-year review. (453716)
1979
40
A clinical approach to the choice of antimicrobial agents, case number 7: aspiration pneumonia. (458256)
1979
41
Incidence of pneumothorax and pneumomediastinum in patients with aspiration pneumonia requiring ventilatory support. (884974)
1977
42
The triple threat of aspiration pneumonia. (1175415)
1975
43
Postoperative aspiration pneumonia. (4717254)
1973
44
Aspiration pneumonia. Clinical outcome following documented aspiration. (4565234)
1973
45
Aspiration pneumonia. A clinical and experimental review. (5333798)
1967
46
Pneumomediastinum and aspiration pneumonia complicating labor. (13670223)
1959
47
Intubation of the esophagus; its role in preventing aspiration pneumonia and asphyxial death. (13394812)
1957
48
Experimental aspiration pneumonia. III. Pneumonia produced by intratracheal injection of carbohydrate solutions. (13137679)
1954
49
ASPIRATION pneumonia. (14869800)
1951
50
Fuel oil aspiration pneumonia. (18915222)
1948

Genetic Variations for Aspiration Pneumonia

Expression for genes affiliated with Aspiration Pneumonia

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aspiration Pneumonia

Search GEO for disease gene expression data for Aspiration Pneumonia.

Pathways for genes affiliated with Aspiration Pneumonia

Sources:
12EMD Millipore
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Pathways related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ELANE, TAC1

Compounds for genes affiliated with Aspiration Pneumonia

Sources:
45Novoseek, 11DrugBank, 29IUPHAR, 50PharmGKB, 24HMDB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Aspiration Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1ulinastatin4510.5ELANE
2sivelestat sodium hydrate4510.1ELANE, IL8
3curosurf4510.1ELANE, IL8
4survanta4510.1IL8, ELANE
5sivelestat4510.1IL8, ELANE
6tlck4510.1ELANE, IL8
7cilomilast4510.1IL8, ELANE
8chymostatin4510.1ACE, ELANE
9fosinopril45 1111.1CRP, ACE
10quinapril45 1111.1ACE, CRP
11ramipril45 1111.0CRP, ACE
12atenolol45 29 50 11 2414.0CRP, ACE
13δ9-tetrahydrocannabinol2910.0GLRA1, TRPM8
14valsartan45 60 29 1113.0ACE, CRP
15telmisartan45 29 1112.0CRP, ACE
16aebsf4510.0IL8, ELANE
17perindopril45 50 1112.0CRP, ACE
18polysulfone4510.0CRP, ELANE
19beta-lactam459.9LACTB, ELANE
20vancomycin45 1110.9LACTB, ELANE
21hydrochlorothiazide45 50 29 11 2413.9ACE, CRP
22ceftriaxone45 1110.8LACTB, CRP
23moxifloxacin45 1110.8LACTB, IL8
24nitroglycerin45 1110.8CRP, ACE, ELANE
25anaphylatoxin459.8ELANE, IL8
26chlorine45 2410.8ELANE, ACE, GLRA1
27gabexate mesilate459.8ELANE, IL8, CRP
28clopidogrel50 45 11 2412.8ACE, CRP
29norepinephrine45 11 2411.8TAC1, ELANE
30neopterin459.7ELANE, IL8, CRP
31clarithromycin45 1110.7LACTB, IL8
32sulfasalazine45 29 50 1112.6CRP, IL8
33aspirin45 50 29 2412.6CRP, ACE, ELANE
34anandamide45 29 60 2412.6GLRA1, TRPM8
35fluticasone propionate45 50 60 1112.6ELANE, IL8
36nedocromil sodium459.6TAC1, IL8
37thiorphan45 29 1111.6TAC1, ACE
38menthol45 29 11 2412.5TRPM8, TAC1
39capsazepine45 60 2911.5TAC1, TRPM8
40azithromycin45 1110.5LACTB, IL8, CRP
41enalapril45 50 1111.4ACE, TAC1
42chloramphenicol45 2 1111.4ELANE, LACTB, CRP
43phosphoramidon45 1110.4TAC1, ACE, ELANE
44captopril45 29 50 60 1113.4ELANE, ACE, TAC1
458-isoprostane459.3IL8, CRP
46nifedipine45 50 29 1112.3GLRA1, TAC1, ACE
47methacholine45 1110.3CRP, IL8, TAC1
48fmlp459.2ELANE, TAC1, IL8
49prostacyclin459.0ELANE, ACE, TAC1, CRP
50acetylcholine45 50 29 11 2413.0ELANE, ACE, TAC1, CRP

GO Terms for genes affiliated with Aspiration Pneumonia

Sources:
16Gene Ontology
See all sources

Cellular components related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9TRPM8, GLRA1, ACE
2extracellular spaceGO:0056158.4ACE, TAC1, IL8, CRP
3extracellular regionGO:0055767.5ELANE, ACE, TAC1, IL8, VASN, CRP

Biological processes related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069548.8TAC1, IL8, CRP

Molecular functions related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:0041759.7ELANE, ACE

Products for genes affiliated with Aspiration Pneumonia

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aspiration Pneumonia

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet