MCID: ASP007
MIFTS: 45

Aspiration Pneumonia malady

Summaries for Aspiration Pneumonia

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A bacterial pneumonia which is an acute pulmonary inflammatory response that develops after the inhalation of colonized oropharyngeal material containing bacteria. it is seen in individuals with dysphagia and gastric dysmotility. the disease has symptom tachypnea and has symptom cough.

MalaCards: Aspiration Pneumonia, also known as pneumonia aspiration, is related to pneumonia and cerebrovascular disease, and has symptoms including tachypneaand cough. An important gene associated with Aspiration Pneumonia is ELANE (elastase, neutrophil expressed), and among its related pathways is Selected targets of C/EBPbeta. The compounds ulinastatin and sivelestat sodium hydrate have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and testes.

Wikipedia:63 Aspiration pneumonia is bronchopneumonia that develops due to the entrance of foreign materials into the... more...

Aliases & Classifications for Aspiration Pneumonia

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 39NCIt, 56SNOMED-CT, 34MeSH
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Aliases & Descriptions:

aspiration pneumonia 8 10 60
pneumonia aspiration 44


External Ids:

Disease Ontology8 DOID:0050152
NCIt39 C34932
SNOMED-CT56 47839005, 422588002
MeSH34 D011015

Related Diseases for Aspiration Pneumonia

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Aspiration Pneumonia via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1pneumonia31.9ELANE, LACTB, IL8, CRP
2cerebrovascular disease30.3ACE
3gastroenteritis29.9LACTB
4bronchiolitis29.9IL8
5influenza29.9LACTB
6respiratory failure29.9TAC1, LACTB, ELANE
7acute pancreatitis29.9ELANE, IL8, CRP
8pancreatitis29.9ELANE, TAC1, CRP
9diabetes mellitus29.9ACE, TAC1, CRP
10hypertension29.9ACE, TAC1, CRP
11anaerobic pneumonia10.4
12esophagitis10.4
13lipid pneumonia10.3
14burns10.3
15achalasia10.3
16laryngitis10.3
17epiglottitis10.2
18bronchiectasis10.2
19laryngotracheitis10.2
20hyperostosis10.2
21megaesophagus10.1
22diffuse idiopathic skeletal hyperostosis10.1
23alzheimer's disease10.1
24aspiration pneumonitis10.1
25cervicitis10.1
26dementia10.1
27sinusitis10.0LACTB
28endophthalmitis10.0LACTB
29otitis media10.0LACTB
30wegener's granulomatosis10.0ELANE
31gingivitis10.0ELANE
32alpha 1-antitrypsin deficiency10.0ELANE
33pancreas disease10.0ELANE
34glomerulonephritis10.0ELANE
35pulmonary disease, chronic obstructive10.0CRP
36acute pyelonephritis10.0CRP
37capillary leak syndrome10.0ELANE
38carotid stenosis10.0CRP
39ulcerative colitis10.0CRP
40rheumatic fever10.0CRP
41pustulosis palmaris et plantaris10.0ELANE
42appendicitis10.0CRP
43aortic aneurysm10.0CRP
44periodontitis10.0IL8
45migraine10.0TAC1
46irritable bowel syndrome10.0TAC1
47cystitis10.0TAC1
48peripheral vascular disease10.0TAC1
49familial mediterranean fever10.0CRP
50hyperhomocysteinemia10.0CRP

Graphical network of the top 20 diseases related to Aspiration Pneumonia:



Diseases related to aspiration pneumonia

Clinical Features for Aspiration Pneumonia

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8Disease Ontology
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Symptoms:

8
  • tachypnea
  • cough

Drugs & Therapeutics for Aspiration Pneumonia

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Aspiration Pneumonia

Drug clinical trials:

Search ClinicalTrials for Aspiration Pneumonia

Search NIH Clinical Center for Aspiration Pneumonia

Search CenterWatch for Aspiration Pneumonia

Genetic Tests for Aspiration Pneumonia

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Anatomical Context for Aspiration Pneumonia

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32MalaCards
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MalaCards organs/tissues related to Aspiration Pneumonia:

32
Colon, Lung, Testes, Brain, Heart, Tongue

Animal Models for Aspiration Pneumonia or affiliated genes

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Publications for Aspiration Pneumonia

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50PubMed
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Articles related to Aspiration Pneumonia:

(show top 50)    (show all 410)
idTitleAuthorsYear
1
Computed tomography findings of aspiration pneumonia in 53 patients. (22994842)
2013
2
A case of bipolar affective disorder and aspiration pneumonia. (23956911)
2013
3
The presence of diatom algae in a tracheal wash from a German Wirehaired Pointer with aspiration pneumonia. (23647227)
2013
4
Constipation and aspiration pneumonia. (22712814)
2012
5
Effect of aging on cough and swallowing reflexes: implications for preventing aspiration pneumonia. (22033612)
2012
6
Prevention of aspiration pneumonia (AP) with oral care. (21764148)
2012
7
Aspiration pneumonia and challenges following the Samoa Tsunami in 2009. (22282279)
2012
8
Aspiration pneumonia and esophagotracheal fistula secondary to button battery ingestion. (21305390)
2011
9
Aspiration pneumonia in the child with DiGeorge syndrome -A case report-. (21738851)
2011
10
New aspirations: the debate on aspiration pneumonia treatment guidelines. (21978335)
2011
11
A report summarizing measures formulated to prevent aspiration pneumonia. (22224359)
2011
12
Potential risks, prognostic indicators, and diagnostic and treatment modalities affecting survival in dogs with presumptive aspiration pneumonia: 125 cases (2005-2008). (20636985)
2010
13
Aspiration syndromes: aspiration pneumonia and pneumonitis. (20469622)
2010
14
Effects of capsiate on the triggering of the swallowing reflex in elderly patients with aspiration pneumonia. (20102390)
2010
15
Bile acid aspiration in suspected ventilator-associated pneumonia. (19318678)
2009
16
Clinical, clinicopathologic, and radiographic findings in dogs with aspiration pneumonia: 88 cases (2004-2006). (19046033)
2008
17
Incidence of aspiration pneumonia in ALS in Olmsted County, MN. (17453635)
2007
18
Aspiration pneumonia as a cause of neonatal death in three captive bottlenose dolphins (Tursiops truncates). (17409655)
2007
19
Effect of aspiration pneumonia-induced sepsis on post-burn cardiac inflammation and function in mice. (16629602)
2006
20
Enterobacter sakazakii in the mouths of stroke patients and its association with aspiration pneumonia. (16618451)
2006
21
Involvement of periodontopathic anaerobes in aspiration pneumonia. (16277588)
2005
22
A probable case of aspiration pneumonia caused by Candida glabrata in a non-neutropenic patient with candidemia. (16357460)
2005
23
Preventive strategies for aspiration pneumonia in elderly disabled persons. (16082150)
2005
24
Microbiology of severe aspiration pneumonia in institutionalized elderly. (12689848)
2003
25
The nasogastric feeding tube as a risk factor for aspiration and aspiration pneumonia. (12690267)
2003
26
Acute stroke predisposes to oral gram-negative bacilli -- a cause of aspiration pneumonia? (12679608)
2003
27
Routine preoperative gastric emptying is seldom indicated. A study of 85,594 anaesthetics with special focus on aspiration pneumonia. (8986180)
1996
28
Prevention of aspiration pneumonia: a research-based protocol. (8697946)
1996
29
Aspiration pneumonia in a mentally handicapped patient due to a foreign body impacted in the pharynx: a near fatal outcome. (8832357)
1996
30
Increased levels of tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) in tracheal aspirates of newborns with pneumonia. (8002082)
1994
31
The association of swallowing dysfunction and aspiration pneumonia. (8131418)
1994
32
Aspiration pneumonia. (1855371)
1991
33
Clostridium tertium bacteremia in a patient with aspiration pneumonia: an elusive diagnosis. (3346578)
1988
34
Treatment of nosocomial aspiration pneumonia and soft-tissue infections in diabetic patients. (3319174)
1987
35
Aspiration pneumonia in an infant with pharyngonasal reflux and left-sided vocal cord paralysis. (3798192)
1987
36
Aspiration pneumonia and coma--an unusual presentation of dystrophic myotonia. (3779503)
1986
37
Aspiration pneumonia in patients fed through nasoenteral tubes. (3084401)
1986
38
Aspiration pneumonia prophylaxis. (6650888)
1983
39
Aspiration pneumonia in institutionalized children. A retrospective comparison of treatment with penicillin G, clindamycin and carbenicillin. (7460462)
1981
40
Percutaneous transtracheal aspiration in the diagnosis and treatment of aspiration pneumonia in children. (6989969)
1980
41
Clindamycin in treatment of aspiration pneumonia in children. (380459)
1979
42
A clinical approach to the choice of antimicrobial agents, case number 7: aspiration pneumonia. (458256)
1979
43
Aspiration pneumonia and anaerobic lung infections. (251325)
1978
44
Incidence of pneumothorax and pneumomediastinum in patients with aspiration pneumonia requiring ventilatory support. (884974)
1977
45
Neonatal milk aspiration pneumonia--a possible additional use for continuous positive airway pressure. (4585443)
1973
46
The view box. Pharyngeal (Zenker's) diverticulum and aspiration pneumonia. (4627662)
1972
47
Experimental aspiration pneumonia. III. Pneumonia produced by intratracheal injection of carbohydrate solutions. (13137679)
1954
48
Aspiration pneumonia due to "lethane" hair-oil. (14848518)
1951
49
The pathogenesis of the vernix membrane; relation to aspiration pneumonia in stillborn and newborn infants. (18131826)
1949
50
The role of delayed gastric emptying time in the etiology of aspiration pneumonia. (18882818)
1948

Genetic Variations for Aspiration Pneumonia

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Expression for genes affiliated with Aspiration Pneumonia

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Aspiration Pneumonia

Search GEO for disease gene expression data for Aspiration Pneumonia.

Pathways for genes affiliated with Aspiration Pneumonia

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12EMD Millipore
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Pathways related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3ELANE, TAC1

Compounds for genes affiliated with Aspiration Pneumonia

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Sources:
44Novoseek, 11DrugBank, 28IUPHAR, 49PharmGKB, 24HMDB, 59Tocris Bioscience, 2BitterDB
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Compounds related to Aspiration Pneumonia according to GeneCards/GeneDecks:

(show top 50)    (show all 53)
idCompoundScoreTop Affiliating Genes
1ulinastatin4410.5ELANE
2sivelestat sodium hydrate4410.1ELANE, IL8
3curosurf4410.1IL8, ELANE
4survanta4410.1ELANE, IL8
5sivelestat4410.1IL8, ELANE
6tlck4410.1IL8, ELANE
7cilomilast4410.1ELANE, IL8
8chymostatin4410.1ACE, ELANE
9fosinopril44 1111.1ACE, CRP
10quinapril44 1111.1ACE, CRP
11ramipril44 1111.0CRP, ACE
12atenolol44 28 49 11 2414.0CRP, ACE
13δ9-tetrahydrocannabinol2810.0GLRA1, TRPM8
14valsartan44 59 28 1113.0ACE, CRP
15telmisartan44 28 1112.0CRP, ACE
16aebsf4410.0ELANE, IL8
17perindopril44 49 1112.0ACE, CRP
18polysulfone4410.0ELANE, CRP
19beta-lactam449.9ELANE, LACTB
20vancomycin44 1110.9LACTB, ELANE
21hydrochlorothiazide44 49 28 11 2413.9ACE, CRP
22ceftriaxone44 1110.8CRP, LACTB
23moxifloxacin44 1110.8IL8, LACTB
24nitroglycerin44 1110.8ACE, CRP, ELANE
25anaphylatoxin449.8ELANE, IL8
26chlorine44 2410.8GLRA1, ELANE, ACE
27gabexate mesilate449.8ELANE, IL8, CRP
28clopidogrel49 44 11 2412.8CRP, ACE
29norepinephrine44 11 2411.8ELANE, TAC1
30neopterin449.7IL8, CRP, ELANE
31clarithromycin44 1110.7LACTB, IL8
32sulfasalazine44 28 49 1112.6IL8, CRP
33aspirin44 49 28 2412.6ACE, CRP, ELANE
34anandamide44 28 59 2412.6GLRA1, TRPM8
35fluticasone propionate44 49 59 1112.6IL8, ELANE
36nedocromil sodium449.6TAC1, IL8
37thiorphan44 28 1111.6TAC1, ACE
38menthol44 28 11 2412.5TRPM8, TAC1
39capsazepine44 59 2811.5TAC1, TRPM8
40azithromycin44 1110.5LACTB, CRP, IL8
41enalapril44 49 1111.4TAC1, ACE
42chloramphenicol44 2 1111.4LACTB, ELANE, CRP
43phosphoramidon44 1110.4ELANE, TAC1, ACE
44captopril44 28 49 59 1113.4TAC1, ELANE, ACE
458-isoprostane449.3CRP, IL8
46nifedipine44 49 28 1112.3TAC1, GLRA1, ACE
47methacholine44 1110.3TAC1, IL8, CRP
48fmlp449.2IL8, ELANE, TAC1
49prostacyclin449.0CRP, TAC1, ACE, ELANE
50acetylcholine44 49 28 11 2413.0ELANE, TAC1, ACE, CRP

GO Terms for genes affiliated with Aspiration Pneumonia

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16Gene Ontology
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Cellular components related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098978.9GLRA1, ACE, TRPM8
2extracellular spaceGO:0056158.4IL8, CRP, TAC1, ACE
3extracellular regionGO:0055767.5ELANE, ACE, TAC1, IL8, VASN, CRP

Biological processes related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:0069548.8TAC1, IL8, CRP

Molecular functions related to Aspiration Pneumonia according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1endopeptidase activityGO:0041759.7ELANE, ACE

Products for genes affiliated with Aspiration Pneumonia

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Aspiration Pneumonia

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet