MCID: AST005
MIFTS: 88

Asthma malady

Genetic diseases, Rare diseases, Respiratory diseases categories

Summaries for Asthma

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Sources:
9Disease Ontology, 35MedlinePlus, 47Novus Biologicals, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Asthma is a chronic disease that affects your airways. your airways are tubes that carry air in and out of your lungs. if you have asthma, the inside walls of your airways become sore and swollen. that makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. when your airways react, they get narrower and your lungs get less air. symptoms of asthma include wheezing coughing, especially early in the morning or at night chest tightness shortness of breath not all people who have asthma have these symptoms. having these symptoms doesn't always mean that you have asthma. your doctor will diagnose asthma based on lung function tests, your medical history, and a physical exam. you may also have allergy tests. when your asthma symptoms become worse than usual, it's called an asthma attack. severe asthma attacks may require emergency care, and they can be fatal. asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms. nih: national heart, lung, and blood institute

MalaCards: Asthma, also known as chronic obstructive asthma, is related to allergic asthma and rhinitis, and has symptoms including coughing, mucus production and shortness of breath. An important gene associated with Asthma is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Allograft rejection. The drugs albuterol and aminophylline and the compounds nitric oxide and histamine have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:9 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. the disease has symptomrecurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. the symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

Novus Biologicals:47 Asthma is a chronic lung disease that causes inflammation, thickening and narrowing of airways, as well as an overproduction of mucus. More than 300 million people worldwide suffer from asthma. Asthma symptoms include wheezing, shortness of breath, coughing and tightness of the chest. Interleukin 13 (IL-13) is the key effector cytokine in asthma. IL-13 stimulates airway fibrosis via action of matrix metalloproteinases (MMPs) on tumor transforming growth factor beta (TGN-beta), and also promotes epithelial damage, mucus production and an increased concentration of eosinophils. The inflammatory response characteristic of asthma is augmented by the production of IL-13 and other TH2 cytokines.

Wikipedia:66 Asthma (from the Greek ?????, more...

Description from OMIM:48 600807

Aliases & Classifications for Asthma

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Sources:
9Disease Ontology, 44NIH Rare Diseases, 21GeneTests, 23GTR, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 41NCIt, 36MeSH, 28ICD9CM, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Aliases & Descriptions:

asthma 9 44 21 23 48 11 46 35 32 63
chronic obstructive asthma 9 46 63
bronchial hyperreactivity 9 46 63
chronic obstructive asthma with status asthmaticus 9
chronic obstructive asthma with acute exacerbation 9
bronchial hypersensitivity 9
asthma, exercise-induced 63
exercise-induced asthma 9
asthma exercise-induced 46
exercise induced asthma 9


Related Diseases for Asthma

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases in the Asthma family:

Asthma 2 Asthma 1

Diseases related to Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 405)
idRelated DiseaseScoreTop Affiliating Genes
1allergic asthma32.0ALOX5, NPSR1, ADAM33, SCGB1A1, SCGB3A2, CCL11
2rhinitis31.7SCGB1A1, CCL11, IL9, IL13
3atopy31.6IL4R, PLA2G7
4allergic rhinitis31.5CCL11, IL4R, IL13, ALOX5
5eosinophilia31.3ALOX5, CCL11, IL9, IL13
6bronchitis31.2IL9, CCL11
7dermatitis31.1ALOX5, CCL11, IL13
8bronchiolitis31.1CCL11, IL13, IL4R
9status asthmaticus31.0ADRB2
10obesity31.0ALOX5, CCL11, ADRB2, TNF, PLA2G7
11pulmonary eosinophilia30.8IL13, CCL11
12pneumonia30.8PLA2G7, IL13, CCL11, SCGB1A1, TNF, ALOX5AP
13atopic dermatitis30.8HAVCR1, HLA-G, TNF, CCL11, IL4R, IL12B
14food allergy30.8CCL11, IL13
15arthritis30.6IL13, TNF, ALOX5, ADRB2
16sinusitis30.6ALOX5, CCL11
17eosinophilic pneumonia30.5CCL11, IL13
18sarcoidosis30.5TNF, SCGB1A1, IL12B, HLA-G, IL13, IL9
19rheumatoid arthritis30.5CCL11, ADRB2, HAVCR1, HLA-G, TNF, IL4R
20tuberculosis30.4IL12B, IL4R, ALOX5, TNF
21pulmonary sarcoidosis30.4TNF, IL12B, IL9
22respiratory failure30.4SCGB1A1, ADRB2, CCL11, IL13, ALOX5
23esophagitis30.2CCL11, IL13
24atherosclerosis30.1ALOX5, ALOX5AP, CCL11, TNF, ADRB2, IL12B
25allergic conjunctivitis30.1CCL11, IL13
26systemic lupus erythematosus30.1PLA2G7, IL12B, IL4R, ADRB2, ALOX5, TNF
27keratoconjunctivitis30.1CCL11, IL13
28sepsis30.1TNF, IL12B, ALOX5, PLA2G7, ADRB2
29insulin resistance30.1PLA2G7, TNF, ADRB2, CCL11
30vernal keratoconjunctivitis30.1IL13, CCL11
31mastocytosis30.1IL13, IL9
32bronchopulmonary dysplasia30.0PLA2G7, SCGB1A1
33breast cancer30.0ALOX5, CCL11, IL4R, HLA-G, SCGB1A1, ALOX5AP
34leukemia30.0HLA-G, TNF, SCGB1A1, IL4R, CCL11, IL12B
35idiopathic pulmonary fibrosis29.9ALOX5, SCGB1A1, IL9, IL13
36gamma chain deficiency29.9IL13, IL4R, IL9
37eosinophilic esophagitis29.9CCL11
38glioblastoma multiforme29.9IL4R, IL13, ALOX5
39hodgkin's lymphoma29.9CCL11, IL13, IL9
40glomerulonephritis29.8SCGB1A1, ALOX5, PLA2G7, ALOX5AP
41type 1 diabetes mellitus29.8CCL11, ADRB2, IL12B, PLA2G7
42pulmonary disease, chronic obstructive29.8IL13, IL9, CCL11, ADRB2, SCGB1A1, TNF
43cerebrovascular disease29.8ALOX5AP, PLA2G7, ADRB2, ALOX5
44myocardial infarction29.8PLA2G7, ALOX5AP, CCL11, ADRB2
45osteoarthritis29.8ALOX5, ALOX5AP, IL12B, IL4R, TNF
46malaria29.8TNF, IL12B
47brain cancer29.8IL13, ALOX5, HLA-G, IL4R
48lung cancer29.8ALOX5, IL9, HLA-G, SCGB1A1, ADRB2
49interstitial lung disease29.8TNF
50psoriasis29.7ALOX5, HLA-G, IL13, IL12B, TNF, IL4R

Graphical network of the top 20 diseases related to Asthma:



Diseases related to asthma

Symptoms for Asthma

About this section
Sources:
48OMIM, 9Disease Ontology
See all sources

Symptoms by clinical synopsis from OMIM:

600807

Clinical features from OMIM:

600807

Symptoms:

9
  • coughing
  • mucus production
  • shortness of breath
  • chest tightness

Drugs & Therapeutics for Asthma

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Asthma

Drug clinical trials:

Search ClinicalTrials for Asthma

Search NIH Clinical Center for Asthma

Highlights from CenterWatch's Drugs in Clinical Trials Database for Asthma:

idCompanyCompoundMechanismPhase
1Chiesi FarmaceuticiCHF 6001An inhaled PDE4 (phosphodiesterase 4) inhibitorIia
2KaloBios PharmaceuticalsKB003A humaneered monoclonal antibodyII
3Rochelebrikizumaba humanized monoclonal antibody inhibiting the IL-13 cytokineIII
4Teva PharmaceuticalsReslizumabA human monoclonal anti-IL-5 antibodyIII

Inferred drug relations via UMLS63/NDF-RT42:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Asthma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asthma:
Bone marrow-derived mesenchymal stem cells for severe refractory asthma
Embryonic/Adult Cultured Cells Related to Asthma:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 21653527, 20801416

Genetic Tests for Asthma

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Sources:
21GeneTests, 23GTR
See all sources

Genetic tests related to Asthma:

id Genetic test Affiliating Genes
1 Asthma, Susceptibility to21 23 HNMT

Anatomical Context for Asthma

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Asthma:

34
Lung, T cells, Testes, Smooth muscle, Heart, Monocytes, Endothelial, Bone, Skin, Trachea, B cells, Breast, Bone marrow, Colon, Myeloid, Liver, Thyroid, Kidney, Bronchial epithelium, Whole blood, Nk cells, Tongue, Thymus, Skeletal muscle, Brain, Lymph node, Placenta, Spleen

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Asthma:
id TissueAnatomical CompartmentCell Relevance
1 LungTracheaAirway Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Asthma or affiliated genes

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Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Asthma:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6NPSR1, HAVCR1, HLA-G, TNF, SCGB1A1, PTGDR
2MP:000537610.6TNF, SCGB1A1, PTGDR, ADRB2, IL4R, IL12B
3MP:000539710.5ADRB2, PTGDR, TNF, HLA-G, HAVCR1, CCL11
4MP:000538810.3HAVCR1, TNF, SCGB1A1, PTGDR, CCL11, IL4R

Publications for Asthma

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Sources:
53PubMed
See all sources

Articles related to Asthma:

(show top 50)    (show all 5516)
idTitleAuthorsYear
1
Is there a role for macrolides in severe asthma? (24247040)
2014
2
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
3
Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. (23727181)
2013
4
The effect of Qi'ao Decoction on ovalbumin induced and lipopolysaccharide enhanced severe asthma mice and its mechanism. (24345505)
2013
5
Siglec-8 and Siglec-F, the new therapeutic targets in asthma. (22324980)
2012
6
Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma: pathogenesis relevance of their FoxP3, GITR, CTLA-4 and FAS expressions. (23241113)
2012
7
Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. (21671842)
2011
8
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
9
Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (20035147)
2010
10
Disease management 360 degrees: a scorecard approach to evaluating TRICARE's programs for asthma, congestive heart failure, and diabetes. (20613658)
2010
11
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis among asthma patients in eastern India. (21661466)
2010
12
Omalizumab reduces oral corticosteroid use in patients with severe allergic asthma: real-life data. (20599369)
2010
13
Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. (18331416)
2009
14
Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. (18768794)
2008
15
Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma. (18926055)
2008
16
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. (18686943)
2008
17
Beta2-adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking. (18238958)
2008
18
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)
2007
19
A functional CD86 polymorphism associated with asthma and related allergic disorders. (17513529)
2007
20
Autologous serum skin test for autoantibodies is associated with airway hyperresponsiveness in patients with asthma. (17028420)
2007
21
Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. (16794249)
2006
22
Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. (16724092)
2006
23
Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma. (16236836)
2005
24
Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. (15502111)
2005
25
Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective. (15940771)
2005
26
The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma. (16450571)
2005
27
The effect of treatment with montelukast on in vitro interleukin-10 production of mononuclear cells of children with asthma. (15725194)
2005
28
Nitric oxide synthase inhibition: therapeutic potential in asthma. (15182209)
2004
29
Plasma eotaxin level and severity of asthma treated with corticosteroid. (15303645)
2004
30
Mechanisms of action of nebulized low molecular weights heparin in patients with bronchial asthma]. (15058258)
2003
31
No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families. (14641543)
2003
32
Endogenous opioids as mediators of asthma. (11603951)
2001
33
Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. (11704612)
2001
34
Management of influenza in patients with asthma or chronic obstructive pulmonary disease. (11770690)
2001
35
Rhinovirus infections: induction and modulation of airways inflammation in asthma. (10421825)
1999
36
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
37
Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. (9723671)
1998
38
Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. (9482706)
1998
39
Relationship between activated eosinophils of the bronchial mucosa and serum eosinophil cationic protein in atopic asthma. (8980465)
1997
40
Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. (9487340)
1997
41
Inflammation of small airways in asthma. (9257786)
1997
42
Activation of CD4+ T cells and increased release of interleukin-5 in cultures of bronchoalveolar lavage cells and PBMC from patients with asthma]. (9387634)
1996
43
Effect of thromboxane A2-receptor antagonist on bradykinin-induced bronchoconstriction in asthma. (8806903)
1996
44
Asthma treatment in pregnancy: a randomized controlled study. (8694041)
1996
45
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
46
Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: evidence and regulation. (7910139)
1994
47
Comparison of the immunopathology of extrinsic, intrinsic and occupational asthma. (7874318)
1994
48
Moderating the inflammation of asthma: inhibiting the production or action of products of the 5-lipoxygenase pathway. (8129222)
1994
49
Effect of salbutamol on left ventricular function and selected biochemical parameters in patients with bronchial asthma]. (7854957)
1994
50
Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. (8342904)
1993

Variations for Asthma

About this section
Sources:
1 National Center for Biotechnology Information (Clinvar)
See all sources

Clinvar genetic disease variations for Asthma:

1
id Gene Name Type Significance SNP ID Assembly Location
1IL4RNM_000418.3(IL4R): c.1507T> C (p.Ser503Pro)single nucleotide variantPathogenic, risk factorrs1805015GRCh37Chr 16, 27374180: 27374180

Expression for genes affiliated with Asthma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Asthma

Search GEO for disease gene expression data for Asthma.

Pathways for genes affiliated with Asthma

About this section
Sources:
51PathCards, 54QIAGEN, 31KEGG, 39NCBI BioSystems Database, 55R&D Systems, 61Thomson Reuters, 52PharmGKB, 56Reactome
See all sources

Pathways related to Asthma according to GeneCards/GeneDecks:

(show all 18)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.6TNF, CCL11, IL4R, IL12B, IL9, IL13
2
Show member pathways
10.5IL13, IL9, IL12B, IL4R, CCL11, TNF
3
Show member pathways
10.5TNF, CCL11, IL4R, IL12B, IL9, IL13
4
Show member pathways
10.5TNF, CCL11, IL4R, IL12B, IL9, IL13
5
Show member pathways
10.5TNF, CCL11, IL4R, IL12B, IL9, IL13
6
Show member pathways
10.5TNF, CCL11, IL4R, IL12B, IL9, IL13
7
Show member pathways
10.5TNF, IL4R, IL12B, IL13, ALOX5
8
Show member pathways
10.5HLA-G, TNF, IL12B, IL13
910.5TNF, IL12B, IL9, IL13
1010.5IL13, IL12B, TNF
11
Show member pathways
Type III interferon signaling39
10.5IL4R, IL12B, IL9, IL13
1210.5IL13, IL9, IL4R
1310.5IL13, IL9
14
Show member pathways
thioredoxin pathway39
10.5TNF, ALOX5AP, ALOX5
15
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
10.5IL9, IL4R, TNF
1610.5ALOX5, ALOX5AP
17
Show member pathways
aspirin triggered resolvin E biosynthesis39
10.5ALOX5AP, ALOX5
1810.5NPSR1, ADRB2, PTGDR

Compounds for genes affiliated with Asthma

About this section
Sources:
46Novoseek, 25HMDB, 12DrugBank, 30IUPHAR, 52PharmGKB, 62Tocris Bioscience
See all sources

Compounds related to Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1nitric oxide46 25 1213.0SCGB1A1, TNF, CCL11, IL12B, ADRB2, IL9
2histamine46 30 2513.0TNF, ADRB2, IL4R, IL13, HNMT, ALOX5AP
3pge24611.0ALOX5, PLA2G7, IL13, ADRB2, ALOX5AP, TNF
4aspirin46 52 30 2514.0ALOX5, ADRB2, CCL11, HNMT, IL13, PLA2G7
5arachidonic acid46 30 25 1214.0ADRB2, IL4R, PTGDR, SCGB1A1, TNF, IL13
6dexamethasone46 52 30 1214.0ALOX5AP, ALOX5, ADRB2, PLA2G7, IL13, IL4R
7leukotriene b446 62 2513.0PLA2G7, IL13, CCL11, TNF, ALOX5, ALOX5AP
8endotoxin4611.0PLA2G7, IL12B, TNF, CCL11, SCGB1A1, IL13
9lipid4611.0TNF, ADRB2, IL12B, IL9, HLA-G, PLA2G7
10montelukast46 52 30 1214.0ALOX5AP, CCL11, ALOX5, IL13, ADRB2
11rolipram46 62 3013.0TNF, ADRB2, IL13, ALOX5, CCL11
12rantes4611.0CCL11, IL4R, IL12B, TNF, IL13, IL9
13methacholine46 52 1213.0NPSR1, IL9, CCL11, ADRB2, IL13
14tarc4611.0TNF, CCL11, IL4R, IL9, IL13
15cycloheximide4610.9TNF, IL13, IL4R, ALOX5AP, IL12B, ALOX5
16indomethacin46 30 62 1213.9ALOX5AP, TNF, PTGDR, IL13, CCL11, ALOX5
17pranlukast46 30 1212.9ALOX5, ALOX5AP, CCL11, TNF
18ltc44610.9CCL11, ALOX5, ALOX5AP, IL13
19fluticasone propionate46 52 62 1213.9IL13, TNF, CCL11, ADRB2
20ionomycin4610.9IL13, IL4R, IL9, TNF, CCL11
21pgd24610.9ALOX5, CCL11, PTGDR, IL13
22il 104610.9IL13, IL12B, TNF, IL4R
23prostaglandin4610.9ALOX5, TNF, PTGDR, CCL11, ALOX5AP
24thymidine46 2511.9TNF, ADRB2, CCL11, IL4R, IL13, IL9
25oxygen46 2511.9SCGB1A1, PLA2G7, HLA-G, TNF, CCL11, ADRB2
26sb 20358046 6211.9ALOX5, TNF, IL12B, IL13, CCL11
27allergens4610.9IL4R, IL9, IL13, CCL11
28lte44610.9CCL11, ALOX5AP, ALOX5
29thromboxane46 2511.9ALOX5, ALOX5AP, PTGDR, PLA2G7
30salmeterol46 52 30 1213.9CCL11, IL13, ADRB2
31calcium46 52 25 1213.9HLA-G, CCL11, PLA2G7, ALOX5, ALOX5AP, SCGB1A1
32il-124610.9IL12B, IL13, TNF
335 aminosalicylic acid4610.8IL12B, TNF, ALOX5
34indoleamine4610.8TNF, IL13, HLA-G
35actinomycin d4610.8TNF, CCL11, IL4R, ALOX5AP, IL13
36groalpha4610.8CCL11, IL13, TNF
37budesonide46 52 1212.8CCL11, TNF, IL13
38vegf4610.8HLA-G, TNF, ADRB2, CCL11, ALOX5, IL13
39sulfasalazine30 46 52 1213.8ALOX5, IL12B, TNF
40salbutamol46 52 30 25 1214.8CCL11, ADRB2, IL13
41fmlp4610.7TNF, CCL11, ALOX5, IL13
42prostacyclin4610.7TNF, PLA2G7, ALOX5, PTGDR
43ndga4610.7TNF, ALOX5AP, ALOX5
44tacrolimus46 52 1212.7ALOX5, IL13, CCL11, TNF
45bay-x 10056210.6ALOX5, ALOX5AP
46bw-b 70c6210.6ALOX5, ALOX5AP
47n-formylmethionyl-leucylphenylalanine4610.5ALOX5, CCL11, TNF
485-hydroxyeicosatetraenoic acid4610.5ALOX5AP, ALOX5
49poly(i-c)4610.4CCL11, TNF, IL12B
50peptidoglycan46 3011.2TNF, IL12B, CCL11

GO Terms for genes affiliated with Asthma

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear envelopeGO:00563510.5ALOX5, ALOX5AP, SCGB1A1
2extracellular spaceGO:00561510.3ALOX5, TNF, SCGB1A1, CCL11, IL4R, IL12B

Biological processes related to Asthma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695410.8IL13, IL9, CCL11, PTGDR, TNF
2leukotriene production involved in inflammatory responseGO:00254010.8ALOX5AP, ALOX5
3response to glucocorticoidGO:05138410.8TNF, SCGB1A1, HNMT
4lipoxin metabolic processGO:200130010.8ALOX5, ALOX5AP
5positive regulation of macrophage activationGO:04303210.7IL13, IL4R
6immune responseGO:00695510.7CCL11, IL4R, IL9, IL13
7lipoxygenase pathwayGO:01937210.7ALOX5, ALOX5AP
8negative regulation of growth of symbiont in hostGO:04413010.7IL12B, TNF
9defense response to protozoanGO:04283210.6IL4R, IL12B
10leukotriene metabolic processGO:00669110.6ALOX5, ALOX5AP
11positive regulation of osteoclast differentiationGO:04567210.6TNF, IL12B
12positive regulation of NF-kappaB import into nucleusGO:04234610.5TNF, IL12B
13positive regulation of interleukin-12 productionGO:03273510.5IL12B, HLA-G
14positive regulation of T cell mediated cytotoxicityGO:00191610.4IL12B, HLA-G
15leukotriene biosynthetic processGO:01937010.2ALOX5, ALOX5AP

Molecular functions related to Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.5IL13, IL9, IL12B, TNF

Products for genes affiliated with Asthma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Asthma

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet