Summaries for Asthma

Sources:
6Disease Ontology, 23MedlinePlus, 2CDC, 44Wikipedia, 33OMIM, 22MalaCards
See all sources

Export this MalaCard
MedlinePlus: Asthma is a chronic disease that affects your airways. your airways are tubes that carry air in and out of your lungs. if you have asthma, the inside walls of your airways become sore and swollen. that makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. when your airways react, they get narrower and your lungs get less air. this can cause wheezing, coughing, chest tightness and trouble breathing, especially early in the morning or at night. when your asthma symptoms become worse than usual, it's called an asthma attack. in a severe asthma attack, the airways can close so much that your vital organs do not get enough oxygen. people can die from severe asthma attacks. asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms. nih: national heart, lung, and blood institute23

MalaCards: Asthma, also known as chronic obstructive asthma, is related to carcinoma and leukemia, and has symptoms including chest tightness, shortness of breath and mucus production. An important gene associated with Asthma is NPSR1 (neuropeptide S receptor 1), and among its related pathways are Tec Kinases Signaling and Antioxidant Action of Vitamin-C. The drugs metaproterenol and ephedrine sulfate and the compounds serine and acetylcholine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and spleen, and related mouse phenotypes are adipose tissue and homeostasis/metabolism.

Disease Ontology: A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. the disease has symptomrecurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. the symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.6

CDC: Asthma is a disease that affects your lungs. It causes repeated episodes of wheezing, breathlessness, chest tightness, and nighttime or early morning coughing. Asthma can be controlled by taking medicine and avoiding the triggers that can cause an attack. You must also remove the triggers in your environment that can make your asthma worse.2

Wikipedia: Asthma (from the Greek ἅσθμα, ásthma, \"panting\") is the common chronic inflammatory disease of...44 more...

OMIM: 600807

Aliases & Descriptions for Asthma

Sources:
2CDC, 6Disease Ontology, 16GeneTests, 8DISEASES, 33OMIM, 32Novoseek , 23MedlinePlus, 43UMLS, 24MeSH, 40SNOMED-CT, 19ICD9CM, 27NCIt
See all sources

Aliases & Descriptions:

asthma 6 16 8 33 32 23 43
chronic obstructive asthma 6 32 43
bronchial hyperreactivity 6 32 43
chronic obstructive asthma with acute exacerbation 6
chronic obstructive asthma with status asthmaticus 6
exercise-induced asthma (disorder) 6
bronchial hypersensitivity 6
asthma, exercise-induced 43
exercise-induced asthma 6
exercise induced asthma 6
asthma exercise-induced 32

Related Diseases for Asthma

Sources:
13GeneCards, 14GeneDecks
See all sources

Disease types for asthma family:

asthma 1 asthma 2

Diseases related to asthma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 882)
idRelated DiseaseScoreTop Affiliating Genes
1carcinoma115.2PIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, LRRC32
2leukemia110.2PIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, SH2B3
3fibrosis94.7PIK3CG, PIN1, LRP1, PDE4A, RECK, RETN
4neuronitis91.1PIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, SH2B1
5pulmonary disease83.6PIK3CG, PIN1, PDE4A, RETN, SFTPA1, SFTPB
6bronchial asthma83.5PDE3B, KITLG, SFTPD, SELE, SELL, SELP
7atherosclerosis82.7PIK3CG, LRP1, PDCD1, PDE4A, RECK, RETN
8thyroiditis81.6PIK3R1, PIK3CG, PIN1, LRP1, PDE10A, PDE4A
9dermatitis79.8PDE3B, PDE4A, CNR1, KITLG, SFTPD, BTK
10pneumonia79.4PDE4A, VTN, SFTPA1, SFTPB, SFTPC, SFTPD
11rhinitis78.1PIK3CD, PIK3CG, PDE4A, RETN, KITLG, SFTPA1
12cholesterol73.9PIK3CD, PIK3R1, PIK3CG, LRP1, PDE3B, RECK
13atopy72.0KITLG, SELP, NAT1, NAT2, VEGFA, VDR
14diabetes mellitus71.7PIK3CD, PIK3R1, PIK3CG, SH2B3, PDCD1, PDE3B
15hypoxia71.5PIK3CD, PIK3R1, PIK3CG, LRP1, PDE4A, RECK
16obesity71.3PIK3R1, PIK3CG, LRP1, SH2B1, PDE10A, PDE3B
17bronchiolitis71.2KIT, KITLG, SFTPA1, SFTPB, SFTPC, SFTPD
18cystic fibrosis70.8PIK3CG, PDE4A, RECK, SFTPA1, SFTPB, SFTPC
19alzheimer's disease70.6PIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, PDE4A
20hypertension70.0PIK3R1, PIK3CG, LRP1, SH2B3, PDE3B, PDE4A
21myocardial infarction68.3PIK3CG, LRP1, SH2B3, PDCD1, PDE4A, RECK
22gonococcal synovitis67.9PIK3R1, PIK3CG, LRP1, PDCD1, PDE3B, PDE4A
23copd64.7PDE4A, SFRP2, SFTPB, SFTPD, GCLC, GC
24sarcoidosis64.6VTN, SFTPD, SELE, SELL, SELP, SERPINA3
25ischemia64.3PIK3CG, PDE4A, RETN, CNR1, KITLG, VTN
26allergic asthma64.0PDE3B, PDE4A, SFTPD, SELE, SELL, NAT2
27influenza63.7PIK3CD, PIK3R1, PIK3CG, RECK, VTN, SFTPA1
28osteoarthritis63.6PIK3CG, PDE4A, RETN, CNR1, VTN, SERPINB2
29blindness58.8PIK3CG, PDE4A, CNR1, SELE, SELP, SERPINA7
30prostatitis57.8PIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, PDCD1
31atopic dermatitis57.5PDE4A, KITLG, SELE, SELL, SELP, VIP
32pancreatitis55.9PIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, PDE3B
33squamous cell carcinoma54.1PIN1, RECK, VTN, SFTPB, PCNA, GC
34sepsis53.3PDE4A, RECK, RETN, VTN, SFTPD, SELE
35eosinophilia53.2PDE3B, PDE4A, SFTPA1, SFTPD, SELL, SERPINA1
36polyposis52.8PIK3CG, PIN1, SH2B3, PDCD1, KITLG, KIF3A
37adenocarcinoma52.5PIK3R1, PIK3CG, PIN1, LRP1, RECK, CNR1
38chronic obstructive pulmonary disease52.3PDE4A, SFTPB, SFTPD, GC, SELPLG, SERPINA1
39melanoma52.0PIK3CD, PIK3R1, PIK3CG, LRP1, PDCD1, PDE3B
40insulin resistance50.9PIK3R1, PIK3CG, LRP1, PDE3B, RETN, RETNLB
41urticaria50.1KIT, KITLG, SELE, SELP, SERPINB1, VEGFA
42infertility49.0RETN, KIT, KITLG, GC, SERPINA1, SERPINE1
43eczema48.6BTK, SELE, VIP, CMA1, MS4A2, MPO
44lupus erythematosus48.1PIK3CD, PIK3CG, SH2B3, PDCD1, RECK, RETN
45sinusitis48.0SFTPD, PCNA, BTK, SELL, SELP, SERPINB3
46esophagitis47.0PIK3CG, PIN1, PDE4A, RECK, CNR1, KIT
47hepatocellular carcinoma47.0PIK3CD, PIK3R1, PIK3CG, PIN1, PDCD1, RECK
48duodenitis46.8PIK3CG, KIT, KITLG, PCNA, VIP, VDR
49gastric cancer46.7PIK3R1, PIK3CG, PIN1, RECK, RETN, RETNLB
50cerebritis45.8PIK3R1, PIK3CG, LRP1, PDE4A, CNR1, KITLG

Graphical network of the top 20 diseases related to asthma:



Graphical network of diseases related to asthma

Clinical Features for Asthma

Sources:
33OMIM, 6Disease Ontology
See all sources
Clinical features from OMIM: 600807
Symptoms: chest tightness, shortness of breath, mucus production, coughing.6

Drugs & Therapeutics for Asthma

Sources:
4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials, 21LifeMap Discovery™, 43UMLS, 28NDF-RT
See all sources

Approved drugs:

Search CenterWatch for asthma

Drug clinical trials:

Search ClinicalTrials for asthma

Search NIH Clinical Center for asthma

Search CenterWatch for asthma

Inferred drug relations via UMLS/NDF-RT:

43 28 [re100] antiasthma/bronchodilators, [re101] anti-inflammatories,inhalation, [re102] bronchodilators,sympathomimetic,inhalation, [re103] bronchodilators,sympathomimetic,oral, [re104] bronchodilators,xanthine-derivative, [re105] bronchodilators,anticholinergic, [re108] antiasthma,antileukotrienes, [re109] antiasthma,other, albuterol, albuterol so4 pwdr [va product], albuterol sulfate, aminophylline, aminophylline dihydrate, aminophylline pwdr [va product], ephedra, ephedrine, ephedrine hydrochloride, ephedrine sulfate, ephedrine tannate, glycerol,iodinated, isoetharine, isoetharine hydrochloride, isoetharine mesylate, metaproterenol, metaproterenol sulfate, montelukast, montelukast sodium, oleandomycin (as troleandomycin), oxtriphylline, pirbuterol, pirbuterol acetate, pseudoephedrine, pseudoephedrine hydrochloride, pseudoephedrine sulfate, terbutaline, terbutaline sulfate, theophylline, theophylline calcium salicylate, theophylline sodium glycinate, theophylline,anhydrous

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Stem-Cell-Based therapeutic approaches for asthma:
Mesenchymal stem cells for treatment of severe refractory asthma
Embryonic/Adult Cultured Cells Related to asthma:
Mesenchymal stem cell, PMIDs: 20801416, 21544902

Genetic Tests for Asthma

Sources:
16GeneTests
See all sources

Genetic tests related to asthma:

id Genetic test Affiliating Genes
1 Asthma
clinical/research
HNMT, ADRB2

Anatomical Context for Asthma

Sources:
21LifeMap Discovery™, 22MalaCards
See all sources

MalaCards organs/tissues related to asthma:

22
Bone marrow, Whole blood, Spleen, Thymus, Brain, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Kidney, Liver, Lung, Thyroid, Breast, Skin, Placenta, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Fetal brain, Tongue, Fetal liver, Fetal lung, Bronchial epithelium, Fetal thyroid

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Embryonic and adult cells/anatomical compartments related to asthma:
id Organ / Tissue -> Anatomical Compartment -> Cell Relevance
1 Lung -> Trachea -> Airway Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Phenotypes for genes affiliated with Asthma

Sources:
25MGI
See all sources

MGI Mouse Phenotypes related to asthma:

25 (show all 28)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1adipose tissue phenotypeMP:0005375INFPIK3R1, LRP1, PDE3B, RETN, CNR1, SERPINE1
2homeostasis/metabolism phenotypeMP:0005376INFPIK3CD, PIK3R1, PIK3CG, LRP1, SH2B1, PDE10A
3behavior/neurological phenotypeMP:0005386INFLRP1, PDE10A, PDE11A, CNR1, KIT, KIF3A
4cardiovascular system phenotypeMP:0005385INFPIK3CD, PIK3R1, PIK3CG, LRP1, PDCD1, PDE4A
5growth/size phenotypeMP:0005378INFPIK3R1, PIK3CG, PIN1, LRP1, SH2B1, PDE10A
6integument phenotypeMP:0010771INFPIK3CG, PIN1, PDE3B, RECK, CNR1, KIT
7liver/biliary system phenotypeMP:0005370INFRECK, RETN, KIT, GCLC, VEGFA, MYB
8hematopoietic system phenotypeMP:000539729.6SH2B3, PDCD1, KIT, PCNA, BTK, SERPINB2
9tumorigenesisMP:000200623.4PIK3R1, KIT, KITLG, SFTPC, BTK, SELL
10vision/eye phenotypeMP:000539121.7PIN1, PDCD1, KIT, KITLG, KIF3A, SFTPC
11reproductive system phenotypeMP:000538921.3SH2B1, SFRP2, SFRP5, SFTPC, SERPINE2, VIP
12muscle phenotypeMP:000536920.0PIK3R1, PIK3CG, LRP1, PDCD1, KIT, SFRP2
13no phenotypic analysisMP:000301218.5PIK3CD, PIK3R1, CNR1, SFRP2, SFTPC, PCNA
14renal/urinary system phenotypeMP:000536718.3PDCD1, KIT, KIF3A, SELP, SELPLG, MYLK
15limbs/digits/tail phenotypeMP:000537115.2RECK, KIT, KITLG, KIF3A, SFRP2, SFRP5
16hearing/vestibular/ear phenotypeMP:000537714.9KIT, KITLG, VDR, BMP2, BMP7, BMPR1A
17craniofacial phenotypeMP:000538214.3KIT, KITLG, KIF3A, BMPR1A, BMPR1B, ZMPSTE24
18other phenotypeMP:000539513.8SH2B3, RECK, CNR1, KDR, LEPR, CD40LG
19normal phenotypeMP:0002873INFPIK3R1, LRP1, VTN, SFRP2, SFRP5, GCLC
20digestive/alimentary phenotypeMP:0005381INFRETNLB, KIT, KITLG, KIF3A, BTK, VEGFA
21cellular phenotypeMP:0005384INFPIK3CD, PIK3R1, PIK3CG, PIN1, SH2B3, PDCD1
22endocrine/exocrine gland phenotypeMP:0005379INFSH2B1, SFRP2, SFRP5, SELL, SERPINE2, BMPR1A
23nervous system phenotypeMP:0003631INFLRP1, PDCD1, PDE11A, PDE4A, RECK, CNR1
24embryogenesis phenotypeMP:0005380INFRECK, KIT, KIF3A, SFRP2, SFRP5, GCLC
25mortality/agingMP:0010768INFLRP1, SH2B1, PDCD1, RECK, RETNLB, CNR1
26skeleton phenotypeMP:0005390INFPIK3CD, PIK3CG, LRP1, RECK, CNR1, KIT
27immune system phenotypeMP:0005387INFPIK3CD, LRP1, SH2B1, PDE4A, RETNLB, KIT
28respiratory system phenotypeMP:0005388INFKIF3A, SFTPC, SFTPD, SELL, SELP, SERPINB1

Publications for genes affiliated with Asthma

Sources:
35PubMed
See all sources

Articles related to asthma:

(show top 50)    (show all 3328)
idTitleAuthorsYearAffiliating Genes
1Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes. (21324137)Lange N.E.... Litonjua A.A.2011TLR9
2Attempted replication of 50 reported asthma risk gene s identifies a SNP in RAD50 as associated with childhood atopic asthma. (21734400)Murk W.... DeWan A.T.2011CCL5, PTPRE, TBXA2R
3TNFalpha inhibitors may improve asthma symptoms: a ca se series of 12 patients with rheumatoid arthritis and asthma. (19455057)Stoll M.L.... Shadick N.A.2009TNF
4Analyses of associations between three positionally c loned asthma candidate genes and asthma or asthma-related phenotypes in a Chine se population. (19951440)Zhou H.... Xu X.2009HLA-G, CYFIP2, ADAM33
5Analyses of associations with asthma in four asthma population samples from Canada and Australia. (19247692)Daley D.... Hudson T.J.2009GSTP1, VDR, TGFB1
6Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: The Fungal Asthma Sensitization Trial (FAST) study. (18948425)Denning D.W.... Niven R.M.2009IGHE
7Cross-sectional and longitudinal association of the secretoglobin 1A1 gene A38G polymorphism with asthma phenotype in the Perth Infant Asthma Follow-up cohort. (19128353)Laing I.A.... Le SouAf P.N.2009SCGB1A1
8Identifying the components of asthma health status in children with mild to moderate asthma. (18466785)Holt E.W.... Fuhlbrigge A.L.2008RNASE3
9Daclizumab improves asthma control in patients with moderate to severe persistent asthma: a randomized, controlled trial. (18787222)Busse W.W.... Shames R.S.2008IL2, IL2RB
10Safety of regadenoson, an adenosine A2A receptor agonist for myocardial perfusion imaging, in mild asthma and moderate asthma patients: a randomized, double-blind, placebo-controlled trial. (18513639)Leaker B.R.... Lieu H.D.2008ADORA2A
11Relative corticosteroid insensitivity of alveolar macrophages in severe asthma compared with non-severe asthma. (18492738)Bhavsar P.... Chung K.F.2008MAPK14, CCL2, IL1B
12Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. (18340359)Wu H.... London S.J.2008NPSR1
13Managing difficult-to-treat asthma: Lessons from a ce nter of excellence in allergy and asthma care. (17612311)Smits W.... Letz K.2007IGHE
14Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma. (17498790)Naqvi M.... Burchard E.G.2007IGHE
15Atopic features of cough variant asthma and classic asthma with wheezing. (17941915)Takemura M.... Mishima M.2007IGHE
16The effectiveness of asthma therapy alternatives and evaluating the effectivity of asthma therapy by interleukin-13 and interferon gamma levels in children. (17479606)Karaman O.... Tezcan D.2007IFNG, IL13
17Transcription factors in asthma: are transcription factors a new target for asthma therapy? (16719769)Roth M.... Black J.L.2006JUN, NR3C1, NFE2L2
18CD14 tobacco gene-environment interaction modifies asthma severity and immunoglobulin E levels in Latinos with asthma. (15879416)Choudhry S.... Burchard E.G.2005CD14
19The CD14 C-159T polymorphism is not associated with asthma or asthma severity in an Australian adult population. (15741437)Kedda M.A.... Upham J.2005CD14
20The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persistent asthma. (15679714)Bousquet J.... Cioppa G.D.2005IGHE
21The effect of polymorphisms at the CD14 promoter and the TLR4 gene on asthma phenotypes in Turkish children with asthma. (16266379)Sackesen C.... Kalayci O.2005TLR4, CD14, IGHE
22Extended haplotype in the tumor necrosis factor gene cluster is associated with asthma and asthma-related phenotypes. (15976383)Randolph A.G.... Weiss S.T.2005TNF, LTA
23Sputum eosinophil counts and eosinophil cationic protein levels in cough-variant asthma and in classic asthma, and their relationships to airway hypersensitivity or maximal airway response to methacholine. (15355463)Yoo Y.... Kim C.K.2004RNASE3
24Sputum eosinophilia in cough-variant asthma as a pred ictor of the subsequent development of classic asthma. (14519148)Kim C.K.... Koh Y.Y.2003RNASE3
25Hospitalization for asthma: atopic, pulmonary function, and psychological correlates among participants in the Childhood Asthma Management Program. (12897312)Bacharier L.B.... Strunk R.C.2003IGES
26Chromosome 12q harbors multiple genetic loci related to asthma and asthma-related phenotypes. (12913068)Raby B.A.... Weiss S.T.2003NOS1
27HLA class II genotypic frequencies in atopic asthma: association of DRB1*01-DQB1*0501 genotype with Artemisia vulgaris allergic asthma. (12878360)Torio A.... Alvarez-Lopez M.R.2003HLA-DQB1, HLA-DRB1
28Discriminant analysis in allergic rhinitis and asthma: methacholine dose-response slope allows a good differentiation between mild asthma and rhinitis. (12556008)Alvarez-Puebla M.J.... Olaguibel-Rivera J.M.2003IGHE
29Matrix metalloproteinase-9 expression in asthma: effect of asthma severity, allergen challenge, and inhaled corticosteroids. (12426251)Mattos W.... Barnes P.J.2002MMP9, TIMP1
30Omalizumab improves asthma-related quality of life in children with allergic asthma. (12415061)Lemanske R.F.... Gupta N.2002IGHE
31Increased interleukin-4 and decreased interferon gamma production in children with asthma: function of atopy or asthma? (11990231)Akpinarli A.... Ozon A.2002IL4, IFNG
32Polyclonal and allergen-induced cytokine responses in adults with asthma: resolution of asthma is associated with normalization of IFN-gamma responses. (12209093)Smart J.M.... Tang M.L.2002IFNG, IL5
33Acupuncture and bronchial asthma: a long-term randomized study of the effects of real versus sham acupuncture compared to controls in patients with bronchial asthma. (12614526)Medici T.C.... WA1thrich B.2002RNASE3
34Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma. (11709756)Howard T.D.... Bleecker E.R.2002IL13, IL4R, IGES
35Genomewide screen and identification of gene-gene interactions for asthma-susceptibility loci in three U.S. populations: collaborative study on the genetics of asthma. (11349227)Xu J.... Cox N.J.2001AASTH24, AASTH21, AASTH22
36Th2 cytokines and asthma. Interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. (11686867)Steinke J.W.... Borish L.2001VCAM1, IL4, IL4R
37Th2 cytokines and asthma. Interleukin-9 as a therapeutic target for asthma. (11686869)Zhou Y.... Levitt R.C.2001IL9
38Serum levels of eosinophilic cationic protein (ECP), myeloperoxidase (MPO), lipid peroxidation products, interleukin (IL)-5 and interferon (IFN)-gamma in children with bronchial asthma at acute asthma attack and remission. (10731862)Kalayci O.... Sekerel B.E.2000MPO, RNASE3
39Immunogenetics of atopic asthma: association of DRB1*1101 DQA1*0501 DQB1*0301 haplotype with Dermatophagoides spp.-sensitive asthma in a sample of the Venezuelan population. (10051703)Lara-Marquez M.L.... Yunis E.1999HLA-DRB1
40Two subphenotypes of childhood asthma that differ in maternal and paternal influences on asthma risk. (10430729)Halonen M.... Martinez F.D.1999IGHE
41Genome-wide search for asthma susceptibility loci in a founder population. The Collaborative Study on the Genetics of Asthma. (9700192)Ober C.... Parry R.1998IL12B, AASTH46, AASTH49
42Difficult-to-control asthma: clinical characteristics of steroid-insensitive asthma. (9600494)Chan M.T.... Spahn J.D.1998IL2RB, RNASE3, IGHE
43Rhinitis and asthma: nasal provocation test in the diagnosis of asthma. (9416559)OlivAc PAcrez A.1997RNASE3
44Evaluation of efficacy of traditional Chinese medicin es in the treatment of childhood bronchial asthma: clinical trial, immunologica l tests and animal study. Taiwan Asthma Study Group. (9116877)Hsieh K.H.1996IL4, IFNG
45Inflammatory determinants of asthma severity: mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. (8939174)Virchow J.C.... Matthys H.1996IL6, IL8, IL4
46IL-4 and IL-5 mRNA and protein in bronchial biopsies from patients with atopic and nonatopic asthma: evidence against 'intrinsic' asthma being a distinct immunopathologic entity. (8912771)Humbert M.... Corrigan C.J.1996IL4, IL5
47Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma. (8880106)Sunyer J.... Roca J.1996IGHE
48Lipoxygenase inhibitor-provoked acute asthma in a patient with asthma relieved by aspirin. (7648373)Imokawa S.... Chida K.1995ALOX5
49Monitoring of asthma inflammation by serum measurements of eosinophil cationic protein (ECP). A new clinical approach to asthma management. (7708973)Venge P.1995RNASE3
50Asthma classification by pathophysiology and IgE-medi ated allergic reaction: new concepts for classification of asthma. (1442158)Tanizaki Y.... Kimura I.1992IGHE

Expression for genes affiliated with Asthma

Sources:
1BioGPS
See all sources
Expression patterns in normal tissues for genes affiliated with Asthma

Pathways for genes affiliated with Asthma

Sources:
36QIAGEN, 20KEGG, 38Reactome, 10EMD Millipore, 41Thomson Reuters
See all sources

Pathways related to asthma according to GeneDecks:

(show top 50)    (show all 212)
idPathwayScoreTop Affiliating Genes
1Tec Kinases Signaling3627.5PIK3R1, KITLG, BTK, BMP2, BMP6, BMP7
2Antioxidant Action of Vitamin-C3626.7KIT, KITLG, BTK, BMP2, BMP6, BMP7
3Akt Signaling3622.4PIK3R1, PIK3CG, PDE3B, KIT, BTK, BMP2
4TGF-Beta Pathway3620.7PIK3R1, KITLG, BTK, BMP2, BMP6, BMP7
5all-trans-Retinoic Acid Signaling in Brain3620.6BTK, BMP2, BMP6, BMP7, BCL2, BAX
6ERK Signaling3619.2PIK3R1, KIT, KITLG, BTK, MYLK, BMP2
7Tuberculosis2018.1VDR, BCL2, CIITA, BAX, LBP, CEBPB
8Endothelin-1 Signaling Pathway3617.6PIK3R1, KIT, BTK, BMP2, BMP6, BMP7
9Rheumatoid arthritis2017.1VEGFA, JUN, CD28, CD86, CD80, ITGAL
10Jak-STAT signaling pathway2017.1PIK3CD, PIK3R1, PIK3CG, LIFR, LEP, LEPR
11Neuroactive ligand-receptor interaction2016.4CNR1, BDKRB2, LEP, LEPR, CHRM2, CHRM1
12Class A/1 (Rhodopsin-like receptors)3816.0CNR1, S1PR1, MC4R, CCL4, CCL7, CCL22
13Phagosome2015.9SFTPA1, SFTPD, MRC1, MPO, CD209, CD36
14Phospholipase-C Pathway3615.7KIT, KITLG, BTK, BMP2, BMP6, BMP7
15NFAT in Immune Response3615.7PIK3R1, KIT, KITLG, BTK, BMP2, BMP6
16NF-KappaB (p50-p65) Pathway3615.4PIK3R1, KITLG, BMP2, BMP6, BMP7, UTS2
17Intestinal immune network for IgA production2015.3CD28, CD86, CD40LG, CD80, CD40, ITGA4
18NF-KappaB Family Pathway3615.2PIK3R1, KITLG, BMP2, BMP6, BMP7, UTS2
19Toll-like receptor signaling pathway2015.0PIK3CD, PIK3R1, PIK3CG, CHUK, LBP, JUN
20TRAF Pathway3614.3PIK3R1, CHUK, JUN, FOS, IRAK1, IRAK3
21Staphylococcus aureus infection2014.2SELP, SELPLG, CFI, ITGAL, ITGAM, ITGB2
22DHA Signaling3614.2PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
23Malaria2013.9LRP1, SELE, SELP, VCAM1, CD36, CD40LG
24Autoimmune thyroid disease2013.9CD28, CD86, CD40LG, CD80, CD40, GZMB
25Glioma Invasiveness3613.8KITLG, VTN, BMP2, BMP6, BMP7, UTS2
26Immune response IL-1 signaling pathway1013.4SERPINE1, CHUK, JUN, JUND, FOS, IRAK1
27Antigen processing and presentation2013.3CIITA, CD4, HSP90AA1, HSP90AB1, HSPA1B, HSPA4
28Immune response_IL-1 signaling pathway4113.3SERPINE1, CHUK, JUN, JUND, FOS, IRAK1
29Rac1 Pathway3613.2PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
30p70S6K Signaling3613.2PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
31Immune response ICOS pathway in T-helper cell1013.2PIK3CD, PIK3R1, PIK3CG, CD28, CD86, CD80
32Toll-Like Receptors Pathway3613.2PIK3R1, BTK, CHUK, LBP, JUN, CD14
33TNF Superfamily Pathway3613.2PIK3R1, CHUK, JUN, FOS, MAPK8, MAPK14
34CDC42 Pathway3613.1KIT, MYLK, LIFR, KDR, CFL1, JUN
35ERK5 Signaling3613.0KIT, KITLG, BMP2, BMP6, BMP7, UTS2
36Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response1013.0CHUK, LBP, JUN, CD14, IRAK1, IRAK3
37Actin-Based Motility by Rho Family GTPases3613.0MYLK, BMP7, UTS2, BDNF, ITGA4, ITGAE
38Estrogen Pathway3612.9PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
39p53 Mediated Apoptosis3612.8PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
40Immune response IL-12-induced IFN-gamma production1012.8CHUK, JUN, IRAK1, IL12A, IL12B, IL12RB1
41Cellular Transformation by HTLV13612.7CHUK, JUN, FOS, MAPK8, IKBKB, IFNG
42GPCR Pathway3612.6PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
43Immune response MIF in innate immunity response1012.6CHUK, LBP, CEBPB, JUN, CD14, IRAK1
44Immune response_MIF in innate immunity response4112.6CHUK, LBP, CEBPB, JUN, CD14, IRAK1
45eNOS Signaling3612.5PIK3R1, KIT, KITLG, BMP2, BMP6, BMP7
46eIF2 Pathway3612.3PIK3R1, KIT, KITLG, BMP6, BMP7, UTS2
4714-3-3 Induced Intracellular Signaling3612.2PIK3R1, KITLG, BMP2, BMP7, UTS2, LIFR
48Telomerase Components in Cell Signaling3612.0KIT, KITLG, BMP2, BMP6, BMP7, UTS2
49IL-6 Pathway36INFPIK3R1, BTK, BMP2, BMP6, BMP7, BAX
50Cell adhesion molecules (CAMs)20INFSELL, SELP, SELPLG, CD28, CD86, CD4

Compounds for genes affiliated with Asthma

Sources:
32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
See all sources

Compounds related to asthma according to GeneDecks:

(show top 50)    (show all 519)
idCompoundScoreTop Affiliating Genes
1serine32 INFPIK3CD, PIK3R1, PIK3CG, PIN1, LRP1, SH2B1
2acetylcholine32 9 18 9 24.9PDE4A, CNR1, SERPINE2, SERPINA3, VIP, BMP6
3cyclic amp32 18 20.8PIK3R1, PDE10A, PDE11A, PDE3B, PDE4A, CNR1
4herbimycin a32 42 20.1PIK3CG, KITLG, VTN, SELE, SELL, VCAM1
5progesterone32 42 9 18 9 21.6PIK3R1, PDE4A, KIT, SFTPB, PCNA, SERPINA7
6n acetylcysteine32 17.0PCNA, GCLC, SELE, SELP, VCAM1, UTS2
7methacholine32 9 9 18.9PDE3B, VIP, CHRM3, MPO, CD79A, CD14
8neopterin32 16.9LGALS3BP, CHIT1, CHKB, MX1, LCN2, CD79A
9hydrocortisone32 9 9 18.9KITLG, BMP6, BGLAP, KDR, CD36, CD14
10quercetin32 42 9 18 9 20.4PIK3CD, PIK3R1, PIK3CG, SELE, LPO, VCAM1
11ccl432 16.2XCL1, ATF3, IL12B, IL13, IL15, IL16
12agarose32 15.5KIT, KITLG, SFTPD, SERPINA7, SERPINA1, LPA
13fluticasone propionate32 42 9 9 18.2SELE, VCAM1, BGLAP, MPO, MMP9, IL13
14ionomycin32 15.1BTK, SERPINA3, KCNN4, CHUK, ATP2A3, CD69
15imatinib32 34 9 9 17.5PIK3R1, PIK3CG, KIT, KITLG, SELL, VIP
16resveratrol32 9 18 9 17.3PIK3CG, PCNA, VEGFA, VDR, BMP2, PARP1
17adenine32 9 18 9 17.2PDE3B, NAT1, NAT2, MYB, SCGB1A1, LEP
18cytarabine32 34 9 9 17.1KIT, KITLG, PCNA, BCL2, CHEK1, BAX
19mannitol32 9 9 16.1SELP, VCAM1, SDHB, CHKB, XDH, CD40LG
20ibuprofen32 9 18 9 17.0VCAM1, BMP6, BDNF, LEP, CHUK, CFTR
21linoleic acid32 18 14.6CETP, ITGAM, MME, IL2RA, ALOX12, ALOX15
22egcg32 13.5PIK3CG, CHUK, IL1A, MAPK8, MAPK14, MAP2K1
23cytochalasin b32 13.4VTN, SELPLG, MPO, CD44, ITGAL, ITGB1
24ndga32 13.2VCAM1, JUN, MMP3, FOS, IL1B, IL2RA
25carvedilol32 34 9 9 16.1SELE, VEGFA, VCAM1, XDH, PTGS1, CYP1A1
26vitamin b1232 12.9PCNA, SERPINA3, LPA, MTHFR, MPO, CD79A
27gf 109203x32 42 13.8PIK3CG, KITLG, BTK, VEGFA, CHRM3, CFTR
28sulforaphane32 12.8PIK3CG, PARP1, BCL2, BAX, JUN, GSTA1
29melphalan32 9 9 14.8GCLC, CHKB, CD79A, MMP2, GSTA1, GSTP1
30okadaic acid32 42 13.7PIK3R1, PDE3B, SERPINB2, MYLK, MYB, BMP6
31sialic acid32 12.6RECK, SELL, SELPLG, SERPINA7, SERPINA3, LPA
32sucrose32 9 18 9 15.5LRP1, RECK, SFTPB, CIITA, CHGA, CHRM1
33rifampicin32 12.3SERPINA7, NAT2, UGT1A6, INHA, GPT, HP
34anisomycin32 42 9 9 15.2PIK3CG, BDNF, ATF3, JUN, JUND, FOS
35cyclophosphamide32 34 9 9 15.2MS4A1, ITGA4, ITGAL, ITGB2, FLT3LG, MBL2
36raloxifene32 9 9 14.0SERPINA7, SERPINE1, VDR, BMP2, BGLAP, CHKB
37ciglitazone32 11.9SERPINE1, PARP1, BAX, JUN, MMP2, MMP9
38cerivastatin32 9 9 13.8SERPINE1, BMP2, CHKB, MMP1, APOA1, CCL2
39silymarin32 11.8PCNA, VEGFA, BMP6, PARP1, CHUK, XDH
40lactose32 9 9 13.8SELE, SELL, LGALS3BP, CFTR, CD40LG, MIF
41irinotecan32 34 9 9 14.3KIT, VEGFA, PARP1, CHEK1, UGT1A6, BAX
42phospholipid32 INFPIK3R1, PDE4A, SFTPB, SFTPC, SFTPD, SERPINA1
43amide32 INFPIN1, CNR1, , CHGA, MT2A, ITGA2
44rantes32 INFKITLG, SELE, SELL, SELP, VIP, VCAM1
45catecholamine32 INFPDE4A, VIP, BDNF, SDHB, , CHGA
46vitamin d32 INFLRP1, GC, SERPINE1, VDR, BMP2, BMP6
47hydrogen32 18 INFPIN1, PDE4A, SFTPB, SFTPC, BTK, SELPLG
48threonine32 INFSH2B1, SFTPB, BTK, SELPLG, SERPINA7, MYLK
49estrogen32 INFPIK3R1, RETN, PCNA, GC, SERPINA7, SERPINB2
50butyrate32 INFKITLG, PCNA, VDR, MYB, BMP6, BCL2

GO Terms for genes affiliated with Asthma

Sources:
12Gene Ontology
See all sources

Cellular components related to asthma according to GeneDecks:

(show all 12)
idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561532.1KIT, KITLG, VTN, SFRP2, SFRP5, SFTPA1
2cytoplasmGO:00573728.4PIK3CG, PIN1, LRP1, KIT, KITLG, RCBTB1
3external side of plasma membraneGO:00989718.3KIT, SELL, SELP, VCAM1, KDR, LAG3
4cell surfaceGO:00998616.1VEGFA, VCAM1, BMP2, BMPR2, RAMP1, CLCN3
5membraneGO:01602014.5PIK3CG, SH2B1, PDE3B, PDE4A, RECK, SELPLG
6membrane raftGO:04512112.4BTK, SELE, P2RX7, MS4A2, CD79A, CD36
7MHC class II protein complexGO:04261312.0HLA-DMA, HLA-DMB, HLA-DOA, HLA-DOB, HLA-DPA1, HLA-DPB1
8integral to lumenal side of endoplasmic reticulum membraneGO:07155611.6HLA-A, HLA-B, HLA-C, HLA-DPA1, HLA-DPB1, HLA-DQA1
9integral to plasma membraneGO:005887INFLRP1, LRRC32, CNR1, SELL, SELP, SELPLG
10plasma membraneGO:005886INFPIK3CD, PIK3R1, PIK3CG, PDCD1, RECK, CNR1
11cytosolGO:005829INFPIK3CD, PIK3R1, PIK3CG, SH2B1, SH2B3, PDE10A
12extracellular regionGO:005576INFRETN, RETNLB, KITLG, VTN, SFTPA1, SFTPD

Biological processes related to asthma according to GeneDecks:

(show top 50)    (show all 75)
idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695526.0VTN, SERPINB4, BMP6, BMPR1A, CIITA, CHIT1
2inflammatory responseGO:00695425.8PIK3CD, PIK3CG, KIT, SELE, SELP, SERPINA3
3signal transductionGO:00716521.2PIK3CD, PDCD1, PDE10A, PDE11A, PDE4A, KIT
4G-protein coupled receptor signaling pathwayGO:00718617.9PIK3CG, VIP, BDKRB2, CHRM2, CHRM1, CHRM3
5innate immune responseGO:04508717.8PIK3CD, PIK3CG, PIN1, SFTPD, BTK, CLEC4D
6cell-cell signalingGO:00726717.6SFRP2, BMP2, XCL1, CD86, CD80, ITGB2
7chemotaxisGO:00693517.3S100A8, FPR2, FGF2, IL4, MAPK14, MAPK1
8positive regulation of transcription from RNA polymerase II promoterGO:04594417.0SFRP2, SERPINE1, VEGFA, VDR, MYB, BMP2
9positive regulation of cell proliferationGO:00828416.7KIT, SFRP2, VIP, VEGFA, LIFR, KDR
10blood coagulationGO:00759616.6PIK3R1, PIK3CG, SH2B1, SH2B3, PDE10A, PDE11A
11cell adhesionGO:00715516.5KITLG, VTN, SELL, SELP, SELPLG, VCAM1
12cell surface receptor signaling pathwayGO:00716615.3LIFR, BDKRB2, LEPR, LAG3, P2RX7, CD28
13negative regulation of cell proliferationGO:00828515.1SFRP2, SFRP5, SERPINE2, VDR, BMP2, BDKRB2
14elevation of cytosolic calcium ion concentrationGO:00720414.9UTS2, BDKRB2, IL1B, IL2, CCR6, CCR2
15xenobiotic metabolic processGO:00680514.6GCLC, GCLM, NAT1, NAT2, UGT1A6, S100A12
16response to virusGO:00961514.6CHRM2, CHUK, MX1, XCL1, CFL1, FOXP3
17positive regulation of inflammatory responseGO:05072914.3SERPINE1, IL12B, IL15, IL18, IL1RL1, IL2
18positive regulation of angiogenesisGO:04576614.3SFRP2, SERPINE1, VEGFA, UTS2, KDR, CHI3L1
19negative regulation of apoptotic processGO:04306614.3PIK3CG, SERPINE1, VEGFA, BDKRB2, KDR, BCL2
20positive regulation of cell migrationGO:03033514.1VEGFA, MYLK, BMP2, KDR, S1PR1, ITGAV
21platelet activationGO:03016813.9PIK3R1, PIK3CG, SELP, SERPINA1, SERPINE1, VEGFA
22cellular calcium ion homeostasisGO:00687413.8VDR, ATP2A2, CD40, ITGB1, CCL15, CCL7
23cellular response to lipopolysaccharideGO:07122213.7SERPINE1, LBP, CD36, CD14, ARG2, ARG1
24positive regulation of peptidyl-tyrosine phosphorylationGO:05073113.4KITLG, VTN, VEGFA, CD36, CD4, CD80
25positive regulation of interleukin-6 productionGO:03275513.4UCN, LBP, P2RX7, CD36, FCER1G, IL1A
26positive regulation of tumor necrosis factor productionGO:03276013.4LBP, CD36, CD14, FCER1G, IL12B, IL18
27female pregnancyGO:00756513.3GC, PAPPA, BCL2, SCGB1A1, LEP, UCN
28positive regulation of smooth muscle cell proliferationGO:04866113.3S1PR1, JUN, FLT1, IL13, IL6, IL6R
29positive regulation of NF-kappaB transcription factor activityGO:05109213.3BTK, CHUK, CD40, IRAK1, IRAK3, INS
30T cell costimulationGO:03129513.1PIK3R1, PDCD1, CD28, CD86, CD4, CD80
31positive regulation of interferon-gamma productionGO:03272913.1CD40LG, IL12A, IL12B, IL12RB1, IL12RB2, IL18
32positive regulation of ERK1 and ERK2 cascadeGO:07037413.0BMP2, KDR, CHI3L1, CD44, MIF, ARRB2
33cellular response to mechanical stimulusGO:07126012.9SFTPB, SFTPC, CHEK1, CD40, ITGB1, IRF1
34lipopolysaccharide-mediated signaling pathwayGO:03166312.9LBP, IRAK1, IL18, IL1B, MAPK14, CCL2
35response to mechanical stimulusGO:00961212.8BMP2, BGLAP, CHI3L1, P2RX7, JUN, MMP9
36positive regulation of protein kinase B signaling cascadeGO:05189712.7PIK3CG, CHI3L1, ARRB2, INS, IL26, ANGPT1
37neutrophil chemotaxisGO:03059312.6PIK3CD, PIK3CG, XCL1, ITGB2, FCER1G, IL1B
38positive regulation of interleukin-12 productionGO:03273512.6CD36, CD40LG, CD40, IL12B, IL23A, CCR7
39regulation of blood pressureGO:00821712.4UTS2, LEP, CHGA, CALCA, HMOX1, PTGS2
40positive regulation of chemokine productionGO:03272212.0LBP, IL18, IL6, IL6R, TNF, HIF1A
41response to hypoxiaGO:001666INFSFTPB, SERPINA1, VEGFA, VCAM1, BMP2, UTS2
42anti-apoptosisGO:006916INFGCLC, SERPINB2, BDNF, BCL2, BCL2A1, CFL1
43response to glucocorticoid stimulusGO:051384INFSFTPB, SFTPC, SERPINE1, BGLAP, UCN, IL10
44response to drugGO:042493INFPDE4A, SFRP2, GCLM, SERPINA7, UTS2, BGLAP
45agingGO:007568INFCNR1, SERPINA7, VDR, VCAM1, JUN, IL15
46response to organic cyclic compoundGO:014070INFSELP, SERPINA1, P2RX7, JUN, IL1A, IL1RN
47interferon-gamma-mediated signaling pathwayGO:060333INFVCAM1, CIITA, MT2A, CD44, IRF1, IRF2
48cytokine-mediated signaling pathwayGO:019221INFPIN1, KIT, VCAM1, LIFR, CIITA, MX1
49response to heatGO:009408INFGCLC, BCL2, CD14, MMP9, IRF1, MICB
50response to lipopolysaccharideGO:032496INFCNR1, SFTPB, SFTPC, SELE, SELP, SERPINA1

Molecular functions related to asthma according to GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1protein bindingGO:005515INFSOCS1, ADAM23, ADAM8, ADRB2, ADORA2A, ADORA1
2cytokine activityGO:00512517.7KITLG, VEGFA, IL18, IL19, IL1A, IL1B
3protein homodimerization activityGO:04280317.2NR6A1, STK10, OXA1L, PRLR, SOD1, CSF1
4chemokine activityGO:00800914.7CCL1, CCL25, CCL3, CCL24, CCL18, CCL13
5growth factor activityGO:00808314.6IL12A, IL12B, IL1B, IL2, IL3, IL4
6protein heterodimerization activityGO:04698214.1TLR1, AHR, AGTR1, HIF1A, HEXB, EGFR
7receptor activityGO:00487213.8PLAUR, DARC, TNFRSF9, TNFRSF10B, TNFRSF10A, F2RL1
8heme bindingGO:02003713.6CYP27B1, CYP27A1, CYP4F3, CYCS, CYBB, CYBA
9heparin bindingGO:00820113.0CTGF, NRP1, PF4, LTF, ABP1, ELANE
10transmembrane signaling receptor activityGO:00488813.0NGFR, EGFR, TLR1, TLR10, TLR2, TLR3
11receptor bindingGO:005102INFPOMC, NPPA, KNG1, C5, C3, ADM

Sources for Asthma

2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS