MCID: AST005
MIFTS: 88

Asthma malady

Respiratory diseases category

Summaries for Asthma

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Sources:
8Disease Ontology, 33MedlinePlus, 3CDC, 45Novus Biologicals, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Asthma is a chronic disease that affects your airways. your airways are tubes that carry air in and out of your lungs. if you have asthma, the inside walls of your airways become sore and swollen. that makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. when your airways react, they get narrower and your lungs get less air. symptoms of asthma include wheezing coughing, especially early in the morning or at night chest tightness shortness of breath not all people who have asthma have these symptoms. having these symptoms doesn't always mean that you have asthma. your doctor will diagnose asthma based on lung function tests, your medical history, and a physical exam. you may also have allergy tests. when your asthma symptoms become worse than usual, it's called an asthma attack. severe asthma attacks may require emergency care, and they can be fatal. asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms. nih: national heart, lung, and blood institute

MalaCards: Asthma, also known as chronic obstructive asthma, is related to allergic asthma and rhinitis, and has symptoms including coughing, mucus production and shortness of breath. An important gene associated with Asthma is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Allograft rejection. The drugs albuterol and aminophylline and the compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are immune system and homeostasis/metabolism.

Disease Ontology:8 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. the disease has symptomrecurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. the symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

CDC:3 Asthma is a disease that affects your lungs. It causes repeated episodes of wheezing, breathlessness, chest tightness, and nighttime or early morning coughing. Asthma can be controlled by taking medicine and avoiding the triggers that can cause an attack. You must also remove the triggers in your environment that can make your asthma worse.

Novus Biologicals:45 Asthma is a chronic lung disease that causes inflammation, thickening and narrowing of airways, as well as an overproduction of mucus. More than 300 million people worldwide suffer from asthma. Asthma symptoms include wheezing, shortness of breath, coughing and tightness of the chest. Interleukin 13 (IL-13) is the key effector cytokine in asthma. IL-13 stimulates airway fibrosis via action of matrix metalloproteinases (MMPs) on tumor transforming growth factor beta (TGN-beta), and also promotes epithelial damage, mucus production and an increased concentration of eosinophils. The inflammatory response characteristic of asthma is augmented by the production of IL-13 and other TH2 cytokines.

Wikipedia:63 Asthma (from the Greek ἅσθμα, ásthma, \"panting\") is a common chronic inflammatory disease of... more...

Description from OMIM:46 600807

Aliases & Classifications for Asthma

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 20GeneTests, 22GTR, 46OMIM, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 39NCIt, 56SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Respiratory diseases


Aliases & Descriptions:

asthma 8 42 20 22 46 10 44 33 30 60
chronic obstructive asthma 8 44 60
bronchial hyperreactivity 8 44 60
chronic obstructive asthma with status asthmaticus 8
chronic obstructive asthma with acute exacerbation 8
bronchial hypersensitivity 8
asthma, exercise-induced 60
exercise-induced asthma 8
asthma exercise-induced 44
exercise induced asthma 8


Related Diseases for Asthma

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Asthma family:

Asthma 2 Asthma 1

Diseases related to Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 385)
idRelated DiseaseScoreTop Affiliating Genes
1allergic asthma31.9ADRB2, ADAM33, CCL11, NPSR1, HAVCR1, ALOX5
2rhinitis31.4IL9, IL13, SCGB1A1, CCL11
3allergic rhinitis31.3CCL11, IL13, IL4R, ALOX5
4eosinophilia31.0CCL11, IL13, IL9, ALOX5
5dermatitis30.8CCL11, ALOX5, IL13
6atopic dermatitis30.8CCL11, TNF, HAVCR1, PHF11, HLA-G, IL13
7bronchiolitis30.8IL4R, IL13, CCL11
8pneumonia30.7CCL11, TNF, SCGB1A1, IL13, PLA2G7, ALOX5AP
9status asthmaticus30.7ADRB2
10cystic fibrosis30.6ADRB2, IL9, SCGB1A1
11arthritis30.5TNF, IL13, ALOX5, ADRB2
12urticaria30.5ALOX5, HNMT
13sarcoidosis30.4CCL11, TNF, SCGB1A1, HLA-G, IL13, IL12B
14rheumatoid arthritis30.4CCL11, TNF, HAVCR1, HLA-G, IL13, IL12B
15eosinophilic pneumonia30.3IL13, CCL11
16diabetes mellitus30.2PLA2G7, TNF
17tuberculosis30.2ALOX5, IL4R, IL12B, TNF
18pulmonary sarcoidosis30.2TNF, IL12B, IL9
19respiratory failure30.1CCL11, SCGB1A1, IL13, ALOX5, ADRB2
20pulmonary fibrosis30.0ALOX5, IL13
21hypertension30.0ADRB2
22atherosclerosis30.0CCL11, TNF, IL12B, PLA2G7, PTGER2, ALOX5AP
23systemic lupus erythematosus30.0TNF, IL12B, IL4R, PLA2G7, ALOX5, ADRB2
24esophagitis30.0IL13, CCL11
25allergic conjunctivitis30.0IL13, CCL11
26measles29.9IL12B
27leukemia29.8CCL11, TNF, SCGB1A1, HLA-G, IL12B, IL9
28breast cancer29.8CCL11, SCGB1A1, HLA-G, IL4R, PTGER2, ALOX5AP
29hepatitis29.8HAVCR1, CCL11
30malaria29.8IL12B, TNF
31myasthenia gravis29.8ADRB2
32bronchiolitis obliterans29.8SCGB1A1
33psoriasis29.6CCL11, TNF, HLA-G, IL13, IL12B, IL4R
34cork-handlers' disease29.6CCL11, TNF, SCGB1A1, HLA-G, IL13, IL9
35inflammatory bowel disease29.6CCL11, TNF, HLA-G, IL13, IL12B, PLA2G7
36osteoarthritis29.6TNF, IL12B, IL4R, ALOX5AP, ALOX5
37melanoma29.6ALOX5, IL4R, HLA-G, TNF, CCL11
38glomerulonephritis29.6SCGB1A1, PLA2G7, ALOX5AP, ALOX5
39myocardial infarction29.6CCL11, PLA2G7, ALOX5AP, ADRB2
40idiopathic pulmonary fibrosis29.6SCGB1A1, IL13, IL9, ALOX5
41alzheimer's disease29.6HNMT, ALOX5AP, ALOX5, ADRB2
42brain cancer29.6HLA-G, IL13, IL4R, ALOX5
43gamma chain deficiency29.6IL13, IL9, IL4R
44lung cancer29.6SCGB1A1, HLA-G, IL4R, PTGER2
45adenoma29.6PTGER2, HLA-G
46ovarian cancer29.6IL4R, HLA-G
47pulmonary disease, chronic obstructive29.6ADRB2
48silicosis29.6SCGB1A1
49celiac disease29.6HLA-G
50encephalitis29.6IL12B

Graphical network of the top 20 diseases related to Asthma:



Diseases related to asthma

Clinical Features for Asthma

About this section
Sources:
46OMIM, 8Disease Ontology
See all sources

Clinical features from OMIM:

600807

Clinical synopsis from OMIM:

600807

Symptoms:

8
  • coughing
  • mucus production
  • shortness of breath
  • chest tightness

Drugs & Therapeutics for Asthma

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Asthma

Drug clinical trials:

Search ClinicalTrials for Asthma

Search NIH Clinical Center for Asthma

Highlights from CenterWatch's Drugs in Clinical Trials Database for Asthma:

idCompanyCompoundMechanismPhase
1Chiesi FarmaceuticiCHF 6001An inhaled PDE4 (phosphodiesterase 4) inhibitorIia
2KaloBios PharmaceuticalsKB003A humaneered monoclonal antibodyII
3Rochelebrikizumaba humanized monoclonal antibody inhibiting the IL-13 cytokineIII
4Teva PharmaceuticalsReslizumabA human monoclonal anti-IL-5 antibodyIII

Inferred drug relations via UMLS60/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Asthma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asthma:
Bone marrow-derived mesenchymal stem cells for severe refractory asthma
Embryonic/Adult Cultured Cells Related to Asthma:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 21653527, 20801416

Genetic Tests for Asthma

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Asthma:

id Genetic test Affiliating Genes
1 Asthma, Susceptibility to20 22 HNMT

Anatomical Context for Asthma

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Sources:
30LifeMap Discovery™, 32MalaCards
See all sources

MalaCards organs/tissues related to Asthma:

32
Lung, T cells, Testes, Smooth muscle, Heart, Monocytes, Endothelial, Bone, Skin, Trachea, B cells, Breast, Bone marrow, Colon, Myeloid, Liver, Thyroid, Kidney, Bronchial epithelium, Whole blood, Nk cells, Tongue, Thymus, Skeletal muscle, Brain, Lymph node, Placenta, Spleen

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Asthma:
id TissueAnatomical CompartmentCell Relevance
1 LungTracheaAirway Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Asthma or affiliated genes

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Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538713.1ADRB2, CCL11, TNF, NPSR1, HAVCR1, SCGB1A1
2MP:000537612.7TNF, SCGB1A1, ADRB2, ALOX5, ALOX5AP, PTGER2
3MP:000539712.3HAVCR1, IL13, IL12B, IL9, TNF, IL4R
4MP:000538812.1CCL11, PTGER2, IL4R, IL12B, SCGB1A1, HAVCR1

Publications for Asthma

About this section
Sources:
50PubMed
See all sources

Articles related to Asthma:

(show top 50)    (show all 5577)
idTitleAuthorsYear
1
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
2
Advances in adult asthma diagnosis and treatment in 2013. (24369799)
2014
3
Associations between selected allergens, phthalates, nicotine, polycyclic aromatic hydrocarbons, and bedroom ventilation and clinically confirmed asthma, rhinoconjunctivitis, and atopic dermatitis in preschool children. (23869823)
2013
4
Asthma, allergy, and responses to methyl donor supplements and nutrients. (24360248)
2013
5
Reduction in oral corticosteroid use in patients receiving omalizumab for allergic asthma in the real-world setting. (24305549)
2013
6
Toward composite molecular signatures in the phenotyping of asthma. (24313773)
2013
7
An inhibitory role for Sema4A in antigen-specific allergic asthma. (23007237)
2013
8
Consider talc too in poorly controlled asthma and unexplained bronchiolitis. (23276875)
2013
9
Asthma associated with incontinentia pigmenti and Fanconi anemia: variable airflow limitation without cellular bronchitis. (23460164)
2013
10
PI3-kinase regulates eosinophil and neutrophil degranulation in patients with allergic rhinitis and allergic asthma irrespective of allergen challenge model. (21384093)
2012
11
Non-invasive positive pressure ventilation for treatment of respiratory failure due to severe acute exacerbations of asthma. (23235608)
2012
12
Th17 cell frequency in peripheral blood from children with allergic asthma correlates with the level of asthma control. (22944005)
2012
13
Asthma, atopy and COPD in sub-Saharan countries: the challenges. (22066305)
2011
14
Persistence of rhinovirus RNA and IP-10 gene expression after acute asthma. (21054674)
2011
15
Eosinophilic bronchitis, eosinophilia associated genetic variants, and notch signaling in asthma. (20592918)
2010
16
Anti-inflammatory effects of the neurotransmitter agonist Honokiol in a mouse model of allergic asthma. (20889543)
2010
17
Inflammatory subtypes in cough-variant asthma: association with maintenance doses of inhaled corticosteroids. (20671058)
2010
18
A case of endobronchial lipoma mimicking bronchial asthma. (23754876)
2009
19
Asthma drugs counter-regulate interleukin-8 release stimulated by sodium sulfite in an A549 cell line. (19373630)
2009
20
Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma. (19733294)
2009
21
C-reactive protein, obesity, atopy and asthma symptoms in middle-aged adults. (18321940)
2008
22
Increased expression of CD30 and CD57 molecules on CD4(+) T cells from children with atopic asthma: a preliminary report. (18201430)
2007
23
Total eosinophil cationic protein levels in induced sputum as a marker of changes in eosinophilic inflammation in a patient with allergic asthma. (16095147)
2005
24
Dissecting asthma using focused transgenic modeling and functional genomics. (16083784)
2005
25
NOD1 variation, immunoglobulin E and asthma. (15718249)
2005
26
Increased oxidative stress in acute exacerbations of asthma. (15801328)
2005
27
Expression of interleukin 4 receptors in bronchial asthma patients who underwent specific immunotherapy. (15281474)
2004
28
Impaired T helper 2 response to aeroallergen in helminth-infected patients with asthma. (15499536)
2004
29
Leptin levels in patients with bronchial asthma and diabetes mellitus]. (12718213)
2003
30
Association of Eotaxin gene family with asthma and serum total IgE. (12761043)
2003
31
Discovery and development of respirable antisense therapeutics for asthma. (12162700)
2002
32
IL-10 serum levels in children with moderate asthma]. (12148173)
2002
33
p38 Mitogen-activated protein kinase-induced glucocorticoid receptor phosphorylation reduces its activity: role in steroid-insensitive asthma. (11941315)
2002
34
7-Methoxyfuro[2,3-c]pyridine-4-carboxamides as PDE4 inhibitors: a potential treatment for asthma. (11814830)
2002
35
The role of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and regulated on activation, normal T-cell expressed and secreted (RANTES) in the relationship between air pollution and asthma among children. (11480498)
2001
36
Blunting airway eosinophilic inflammation results in a decreased airway neutrophil response to inhaled LPS in patients with atopic asthma: a role for CD14. (11590384)
2001
37
Association of HLA-DRB1(*)07 and DRB1(*)04 to citrus red mite (Panonychus citri) and house dust mite sensitive asthma. (11069565)
2000
38
Sputum matrix metalloproteinase-9: tissue inhibitor of metalloproteinase-1 ratio in acute asthma. (10808169)
2000
39
Tests for bronchial asthma]. (11215421)
2000
40
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
41
Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. (9723671)
1998
42
Adherence and compliance in the management of asthma: 2. (10076216)
1998
43
T-lymphocyte responses to plicatic acid-human serum albumin conjugate in occupational asthma caused by western red cedar. (9648713)
1998
44
Clinical improvement of asthma after anthelminthic treatment in a tropical situation. (9230725)
1997
45
Association between toluene diisocyanate-induced asthma and DQB1 markers: a possible role for aspartic acid at position 57. (8777952)
1996
46
Plasma zinc, copper and copper/zinc ratio in intrinsic asthma. (8793823)
1996
47
Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. (8598621)
1996
48
Effect of pilocarpine on propranolol-induced bronchoconstriction in asthma. (8111602)
1994
49
Interpretation of skin tests to house dust mite and relationship to other allergy parameters in patients with asthma and chronic obstructive pulmonary disease. The Dutch CNSLD Study Group. (8436772)
1993
50
Bronchodilator, cardiovascular, and cyclic guanylyl monophosphate response to high-dose infused atrial natriuretic peptide in asthma. (8387254)
1993

Genetic Variations for Asthma

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Expression for genes affiliated with Asthma

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Asthma

Search GEO for disease gene expression data for Asthma.

Pathways for genes affiliated with Asthma

About this section
Sources:
51QIAGEN, 29KEGG, 12EMD Millipore, 37NCBI BioSystems Database, 52R&D Systems, 53Reactome, 49PharmGKB
See all sources

Pathways related to Asthma according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.8CCL11, TNF, IL13, IL12B, IL9, IL4R
2
Hide members
11.8IL9, IL12B, IL4R, CCL11, TNF, HLA-G
3
Hide members
11.6IL4R, PLA2G7, IL13, HLA-G, TNF, CCL11
4
Hide members
11.6IL4R, CCL11, IL12B, IL13, IL9, TNF
5
Hide members
11.6IL4R, IL12B, IL13, TNF, CCL11, IL9
6
Hide members
11.6IL4R, IL9, IL12B, IL13, TNF, CCL11
7
Hide members
11.2IL13, HLA-G, TNF, IL12B
811.2TNF, IL13, IL9, IL12B
9
Hide members
11.2IL13, IL9, IL4R, CCL11
10
Hide members
11.2IL4R, ALOX5, IL12B, IL13
1111.2IL12B, IL13, IL4R, IL9
1211.0IL12B, IL13, TNF
1311.0IL13, IL9, IL4R
1411.0TNF, ALOX5, ALOX5AP
15
Hide members
10.9ALOX5AP, ALOX5
16
Hide members
10.9ALOX5, ALOX5AP

Compounds for genes affiliated with Asthma

About this section
Sources:
44Novoseek, 28IUPHAR, 24HMDB, 49PharmGKB, 11DrugBank, 59Tocris Bioscience
See all sources

Compounds related to Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 75)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2414.8ADRB2, ALOX5, ALOX5AP, PTGER2, IL4R, IL13
2dexamethasone44 49 28 1115.8CCL11, TNF, HLA-G, PTGER2, ADRB2, ALOX5
3nitric oxide44 11 2414.8ALOX5AP, CCL11, TNF, SCGB1A1, IL13, IL12B
4arachidonic acid44 28 11 2415.6PTGER2, ADRB2, TNF, ALOX5AP, PLA2G7, IL13
5lipid4412.6IL12B, CCL11, TNF, PLA2G7, HLA-G, SCGB1A1
6aspirin44 49 28 2415.4ALOX5AP, ADRB2, ALOX5, PTGER2, PLA2G7, IL13
7vegf4412.2ADRB2, CCL11, TNF, HLA-G, IL13, PTGER2
8leukotriene b444 59 2414.0TNF, IL13, ALOX5AP, ALOX5, PLA2G7, CCL11
9indomethacin44 59 28 1115.0CCL11, ALOX5, ALOX5AP, PTGER2, IL13, TNF
10thymidine44 2413.0TNF, IL13, CCL11, IL4R, ADRB2, IL9
11oxygen44 2412.9HLA-G, SCGB1A1, TNF, CCL11, ADRB2, PLA2G7
12montelukast44 49 28 1114.9ALOX5, ALOX5AP, IL13, CCL11, ADRB2
13methacholine44 1112.9IL9, ADRB2, CCL11, IL13, NPSR1
14tarc4411.8CCL11, IL13, TNF, IL9, IL4R
15rantes4411.8TNF, CCL11, IL9, IL4R, IL12B
16ionomycin4411.8IL4R, IL9, IL13, TNF, CCL11
17prostaglandin4411.8CCL11, TNF, PTGER2, ALOX5, ALOX5AP
18sb 20358044 5912.8TNF, CCL11, IL13, IL12B, ALOX5
19pge24411.7ADRB2, CCL11, ALOX5AP, PLA2G7
20actinomycin d4411.7ALOX5AP, IL4R, CCL11, TNF, IL13
21pranlukast44 28 1113.7ALOX5, ALOX5AP, TNF, CCL11
22ltc44411.6CCL11, IL13, ALOX5AP, ALOX5
23fluticasone propionate44 49 59 1114.6ADRB2, CCL11, IL13, TNF
24pgd24411.6IL13, CCL11, ALOX5, PTGER2
25il 104411.6TNF, IL13, IL12B, IL4R
26phosphatidylinositol4411.6SCGB1A1, IL13, IL12B, IL4R, PTGER2, CCL11
27thromboxane44 2412.6PTGER2, ALOX5AP, PLA2G7, ALOX5
28allergens4411.6CCL11, IL9, IL4R, IL13
29bromodeoxyuridine4411.5PTGER2, IL9, SCGB1A1, IL13
30serine4411.5ALOX5, ADRB2, IL13, IL9, TNF
31lte44411.4ALOX5AP, CCL11, ALOX5
32salmeterol44 49 28 1114.4IL13, CCL11, ADRB2
33il-124411.4IL13, IL12B, TNF
345 aminosalicylic acid4411.4IL12B, TNF, ALOX5
35indoleamine4411.4HLA-G, TNF, IL13
36groalpha4411.3IL13, CCL11, TNF
37fmlp4411.3TNF, IL13, ALOX5, CCL11
38budesonide44 49 1113.3TNF, CCL11, IL13
39salbutamol44 49 28 11 2415.3IL13, ADRB2, CCL11
40sulfasalazine44 28 49 1114.3IL12B, TNF, ALOX5
41rolipram44 59 2813.3ADRB2, ALOX5
42endotoxin4411.3PLA2G7, SCGB1A1
43cycloheximide4411.3ALOX5AP, PLA2G7
44prostacyclin4411.2ALOX5, TNF, PLA2G7, PTGER2
45ndga4411.2TNF, ALOX5AP, ALOX5
465-hydroxyeicosatetraenoic acid4411.1ALOX5AP, ALOX5
47bw-b 70c5911.1ALOX5, ALOX5AP
48bay-x 10055911.0ALOX5AP, ALOX5
49poly(i-c)4410.9CCL11, TNF, IL12B
50tacrolimus44 49 1112.9CCL11, TNF, IL13, ALOX5

GO Terms for genes affiliated with Asthma

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561511.5IL4R, CCL11, TNF, SCGB1A1, IL13, IL12B
2nuclear envelopeGO:00563511.0ALOX5, ALOX5AP, SCGB1A1

Biological processes related to Asthma according to GeneCards/GeneDecks:

(show all 11)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.3IL9, IL13, TNF, CCL11
2response to glucocorticoid stimulusGO:05138411.2HNMT, TNF, SCGB1A1
3leukotriene production involved in inflammatory responseGO:00254011.1ALOX5, ALOX5AP
4lipoxin metabolic processGO:200130011.1ALOX5, ALOX5AP
5response to lipopolysaccharideGO:03249611.0PTGER2, IL13, SCGB1A1
6positive regulation of macrophage activationGO:04303211.0IL4R, IL13
7lipoxygenase pathwayGO:01937211.0ALOX5, ALOX5AP
8negative regulation of growth of symbiont in hostGO:04413010.9IL12B, TNF
9defense response to protozoanGO:04283210.9IL4R, IL12B
10leukotriene metabolic processGO:00669110.8ALOX5, ALOX5AP
11positive regulation of osteoclast differentiationGO:04567210.6TNF, IL12B

Molecular functions related to Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.2IL9, IL12B, IL13, TNF

Products for genes affiliated with Asthma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Asthma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet