MCID: AST005
MIFTS: 84

Asthma malady

Genetic diseases, Rare diseases, Respiratory diseases categories

Aliases & Classifications for Asthma

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Asthma, Aliases & Descriptions:

Name: Asthma 45 30 9 41 20 11 43 22 32 3 60
Chronic Obstructive Asthma 9 43 60
Bronchial Hyperreactivity 9 43 60
Asthma, Diminished Response to Antileukotriene Treatment in 45 10
Chronic Obstructive Asthma with Status Asthmaticus 9 60
Chronic Obstructive Asthma with Acute Exacerbation 9
Chronic Obstructive Asthma with Exacerbation 60
 
Asthma, Protection Against 45
Asthma, Exercise-Induced 60
Exercise Induced Asthma 9
Asthma Exercise-Induced 43
Exercise-Induced Asthma 9
Asthma, Nocturnal 45


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


External Ids:

OMIM45 600807
Disease Ontology9 DOID:2841
ICD9CM27 493, 493.9
NCIt38 C28397
MeSH33 D001249
ICD1025 J45

Summaries for Asthma

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MedlinePlus:32 Asthma is a chronic disease that affects your airways. your airways are tubes that carry air in and out of your lungs. if you have asthma, the inside walls of your airways become sore and swollen. that makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. when your airways react, they get narrower and your lungs get less air. symptoms of asthma include wheezing coughing, especially early in the morning or at night chest tightness shortness of breath not all people who have asthma have these symptoms. having these symptoms doesn't always mean that you have asthma. your doctor will diagnose asthma based on lung function tests, your medical history, and a physical exam. you may also have allergy tests. when your asthma symptoms become worse than usual, it's called an asthma attack. severe asthma attacks may require emergency care, and they can be fatal. asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms. nih: national heart, lung, and blood institute

MalaCards based summary: Asthma, also known as chronic obstructive asthma, is related to allergic asthma and rhinitis, and has symptoms including recurring periods of wheezing (a whistling sound while breathing), chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (interleukin 13), and among its related pathways are PEDF Induced Signaling and PAK Pathway. The drugs albuterol and aminophylline and the compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are immune system and hematopoietic system.

Disease Ontology:9 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. the disease has symptom recurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. the symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety.

CDC:3 Asthma is a disease that affects your lungs. It causes repeated episodes of wheezing, breathlessness, chest tightness, and nighttime or early morning coughing. Asthma can be controlled by taking medicine and avoiding the triggers that can cause an attack. You must also remove the triggers in your environment that can make your asthma worse.

OMIM:45 Bronchial asthma is the most common chronic disease affecting children and young adults. It is a complex genetic... (600807) more...

Novus Biologicals:44 Asthma is a chronic lung disease that causes inflammation, thickening and narrowing of airways, as well as an overproduction of mucus. More than 300 million people worldwide suffer from asthma. Asthma symptoms include wheezing, shortness of breath, coughing and tightness of the chest. Interleukin 13 (IL-13) is the key effector cytokine in asthma. IL-13 stimulates airway fibrosis via action of matrix metalloproteinases (MMPs) on tumor transforming growth factor beta (TGN-beta), and also promotes epithelial damage, mucus production and an increased concentration of eosinophils. The inflammatory response characteristic of asthma is augmented by the production of IL-13 and other TH2 cytokines.

Wikipedia:63 Asthma (from the Greek ?????, more...

Related Diseases for Asthma

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Diseases in the Asthma family:

Asthma 2 Asthma 1

Diseases related to Asthma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 410)
idRelated DiseaseScoreTop Affiliating Genes
1allergic asthma32.9HAVCR1, ALOX5AP, PLA2G7, IL13, IL9, IL4R
2rhinitis32.6IL13, IL9, CCL11
3allergic rhinitis32.4ALOX5, IL13, IL4R, CCL11
4atopy32.4PLA2G7, IL4R
5eosinophilia32.2CCL11, IL9, IL13, ALOX5
6bronchiolitis31.9CCL11, IL4R, IL13
7dermatitis31.8IL4R, IL13
8bronchitis31.8IL9, CCL11
9status asthmaticus31.7ADRB2
10pulmonary eosinophilia31.6IL13, CCL11
11food allergy31.6CCL11, IL13
12obesity31.5ALOX5, PLA2G7, CCL11, ADRB2, TNF
13pneumonia31.4TNF, CCL11, IL13, PLA2G7, ALOX5AP
14atopic dermatitis31.4SPINK5, CCL11, IL13
15eosinophilic pneumonia31.3CCL11, IL13
16arthritis31.2TNF, ADRB2, IL13, ALOX5
17respiratory failure31.2ADRB2, CCL11, IL13, ALOX5
18sinusitis31.1ALOX5, CCL11
19esophagitis31.0CCL11, IL13
20tuberculosis31.0TNF, IL4R, IL12B, ALOX5
21pulmonary sarcoidosis31.0IL9, IL12B, TNF
22rheumatoid arthritis30.9HAVCR1, HLA-G, TNF, ADRB2, CCL11, IL4R
23allergic conjunctivitis30.9CCL11, IL13
24keratoconjunctivitis30.9CCL11, IL13
25mastocytosis30.8IL13, IL9
26atherosclerosis30.8TNF, ADRB2, CCL11, IL12B, PLA2G7, ALOX5AP
27vernal keratoconjunctivitis30.8IL13, CCL11
28systemic lupus erythematosus30.7TNF, ADRB2, IL4R, IL12B, PLA2G7, ALOX5
29glioblastoma multiforme30.7ALOX5, IL13, IL4R
30myocardial infarction30.6ALOX5AP, PLA2G7, CCL11, ADRB2
31glomerulonephritis30.5PLA2G7, ALOX5AP, ALOX5
32osteoarthritis30.4TNF, IL4R, IL12B, ALOX5AP, ALOX5
33brain cancer30.4HLA-G, IL4R, IL13, ALOX5
34leukemia30.3HLA-G, TNF, CCL11, IL4R, IL12B, IL9
35malaria30.3TNF, IL12B
36interstitial lung disease30.2TNF
37cork-handlers' disease30.0HLA-G, TNF, ADRB2, CCL11, IL9, IL13
38inflammatory bowel disease30.0HLA-G, TNF, CCL11, IL12B, IL13, PLA2G7
39melanoma29.9HLA-G, TNF, CCL11, IL4R, ALOX5
40psoriasis29.9ALOX5, IL13, IL12B, IL4R, CCL11, ADRB2
41cough variant asthma10.8
42intrinsic asthma10.8
43severe combined immunodeficiency, x-linked10.7IL13, IL9, IL4R
44pulmonary fibrosis, idiopathic10.7ALOX5, IL13, IL9
45multicentric reticulohistiocytosis10.7HAVCR1
46esophagitis, eosinophilic, 110.6CCL11
47aspergillosis10.6
48allergic bronchopulmonary aspergillosis10.6
49hodgkin lymphoma10.6CCL11, IL9, IL13
50lipoid nephrosis10.6IL13, IL4R

Graphical network of the top 20 diseases related to Asthma:



Diseases related to asthma

Symptoms for Asthma

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Symptoms by clinical synopsis from OMIM:

600807

Clinical features from OMIM:

600807

Symptoms:

 9
  • recurring periods of wheezing (a whistling sound while breathing)
  • chest tightness
  • shortness of breath
  • mucus production
  • coughing

HPO human phenotypes related to Asthma:

id Description Frequency HPO Source Accession
1 asthma HP:0002099

Drugs & Therapeutics for Asthma

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Drug clinical trials:

Search ClinicalTrials for Asthma

Search NIH Clinical Center for Asthma

Inferred drug relations via UMLS60/NDF-RT39:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Asthma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asthma:
Bone marrow-derived mesenchymal stem cells for severe refractory asthma
Embryonic/Adult Cultured Cells Related to Asthma:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 21653527, 20801416

Genetic Tests for Asthma

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Genetic tests related to Asthma:

id Genetic test Affiliating Genes
1 Asthma, Susceptibility to20 22 HNMT

Anatomical Context for Asthma

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MalaCards organs/tissues related to Asthma:

31
Lung, T cells, Testes, Neutrophil, Smooth muscle, Heart, Monocytes, Endothelial, Bone, Skin, B cells, Trachea, Bone marrow, Breast, Colon, Liver, Myeloid, Bronchial epithelium, Whole blood, Kidney, Thyroid, Nk cells, Lymph node, Spleen, Thymus, Brain, Skeletal muscle, Placenta, Tongue

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Asthma:
id TissueAnatomical CompartmentCell Relevance
1 LungTracheaAirway Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Asthma or affiliated genes

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MGI Mouse Phenotypes related to Asthma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.8NPSR1, HAVCR1, SPINK5, HLA-G, TNF, ADRB2
2MP:000539710.7ADRB2, TNF, HLA-G, SPINK5, HAVCR1, CCL11
3MP:000538810.6TNF, CCL11, IL4R, IL12B, IL13, NPSR1
4MP:000537610.4SPINK5, HLA-G, TNF, ADRB2, IL4R, IL12B

Publications for Asthma

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Articles related to Asthma:

(show top 50)    (show all 5737)
idTitleAuthorsYear
1
Childhood allergic asthma is associated with increased IL-13 and FOXP3 histone acetylation. (25769912)
2015
2
Nasal Il-17f Is Related To Bronchial Il-17f/Neutrophilia And Exacerbations In Stable Atopic Severe Asthma. (25394579)
2014
3
Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma. (25341726)
2014
4
Is there a role for macrolides in severe asthma? (24247040)
2014
5
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
6
Cases of occupational dermatitis and asthma in beauticians that were reported to The Health and Occupation Research (THOR) network from 1996 to 2011. (24934913)
2014
7
Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. (23727181)
2013
8
The effect of Qi'ao Decoction on ovalbumin induced and lipopolysaccharide enhanced severe asthma mice and its mechanism. (24345505)
2013
9
Siglec-8 and Siglec-F, the new therapeutic targets in asthma. (22324980)
2012
10
Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma: pathogenesis relevance of their FoxP3, GITR, CTLA-4 and FAS expressions. (23241113)
2012
11
Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. (21671842)
2011
12
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
13
Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (20035147)
2010
14
Disease management 360 degrees: a scorecard approach to evaluating TRICARE's programs for asthma, congestive heart failure, and diabetes. (20613658)
2010
15
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis among asthma patients in eastern India. (21661466)
2010
16
Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. (18331416)
2009
17
Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma. (18926055)
2008
18
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. (18686943)
2008
19
Beta2-adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking. (18238958)
2008
20
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)
2007
21
A functional CD86 polymorphism associated with asthma and related allergic disorders. (17513529)
2007
22
Autologous serum skin test for autoantibodies is associated with airway hyperresponsiveness in patients with asthma. (17028420)
2007
23
Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. (16724092)
2006
24
Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma. (16236836)
2005
25
Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. (15502111)
2005
26
Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective. (15940771)
2005
27
The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma. (16450571)
2005
28
Nitric oxide synthase inhibition: therapeutic potential in asthma. (15182209)
2004
29
Plasma eotaxin level and severity of asthma treated with corticosteroid. (15303645)
2004
30
Mechanisms of action of nebulized low molecular weights heparin in patients with bronchial asthma]. (15058258)
2003
31
No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families. (14641543)
2003
32
Endogenous opioids as mediators of asthma. (11603951)
2001
33
Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. (11704612)
2001
34
Management of influenza in patients with asthma or chronic obstructive pulmonary disease. (11770690)
2001
35
Rhinovirus infections: induction and modulation of airways inflammation in asthma. (10421825)
1999
36
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
37
Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. (9723671)
1998
38
Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. (9482706)
1998
39
Relationship between activated eosinophils of the bronchial mucosa and serum eosinophil cationic protein in atopic asthma. (8980465)
1997
40
Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. (9487340)
1997
41
Inflammation of small airways in asthma. (9257786)
1997
42
Activation of CD4+ T cells and increased release of interleukin-5 in cultures of bronchoalveolar lavage cells and PBMC from patients with asthma]. (9387634)
1996
43
Effect of thromboxane A2-receptor antagonist on bradykinin-induced bronchoconstriction in asthma. (8806903)
1996
44
Asthma treatment in pregnancy: a randomized controlled study. (8694041)
1996
45
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
46
Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: evidence and regulation. (7910139)
1994
47
Comparison of the immunopathology of extrinsic, intrinsic and occupational asthma. (7874318)
1994
48
Moderating the inflammation of asthma: inhibiting the production or action of products of the 5-lipoxygenase pathway. (8129222)
1994
49
Effect of salbutamol on left ventricular function and selected biochemical parameters in patients with bronchial asthma]. (7854957)
1994
50
Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-gamma cytokine gene expression. (8342904)
1993

Variations for Asthma

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Clinvar genetic disease variations for Asthma:

6
id Gene Variation Type Significance SNP ID Assembly Location
1TNFTNF, -308G-Asingle nucleotide variantrisk factor
2IL4RNM_000418.3(IL4R): c.1507T> C (p.Ser503Pro)single nucleotide variantPathogenic, risk factorrs1805015GRCh37Chr 16, 27374180: 27374180
3IL13IL13, -1112C-Tsingle nucleotide variantrisk factor
4IL13NM_002188.2(IL13): c.431A> G (p.Gln144Arg)single nucleotide variantrisk factorrs20541GRCh37Chr 5, 131995964: 131995964
5SCGB3A2SCGB3A2, -112G/Asingle nucleotide variantrisk factor
6HNMTNM_006895.2(HNMT): c.314C> T (p.Thr105Ile)single nucleotide variantrisk factorrs11558538GRCh37Chr 2, 138759649: 138759649
7SPINK5NM_006846.3(SPINK5): c.1258A> G (p.Lys420Glu)single nucleotide variantrisk factorrs2303067GRCh37Chr 5, 147480955: 147480955
8CCL11CCL11, (GAAGGA)nundetermined variantrisk factor

Expression for genes affiliated with Asthma

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LifeMap Discovery
Genes differentially expressed in tissues of Asthma patients vs. healthy controls: 30 (show all 18)
id Gene Description Tissue Up/Dn Fold Change (log2) P value
1TATtyrosine aminotransferaseBlood-3.700.004
2LOC100130642uncharacterized LOC100130642Blood-3.620.001
3GPRC5BG protein-coupled receptor, class C, group 5, member BBlood-3.590.005
4KCNK1potassium channel, subfamily K, member 1Blood-3.550.003
5DNMBPdynamin binding proteinBlood-3.490.002
6TAAR1trace amine associated receptor 1Blood-3.490.021
7ARL10ADP-ribosylation factor-like 10Blood-3.470.000
8LMBRD2LMBR1 domain containing 2Blood-3.430.002
9LAMB4laminin, beta 4Blood-3.430.001
10RHOJras homolog family member JBlood-3.410.007
11AKR1D1aldo-keto reductase family 1, member D1Blood-3.370.019
12FBXO4F-box protein 4Blood-3.370.002
13AGAP1ArfGAP with GTPase domain, ankyrin repeat and PH domain 1Blood-3.360.039
14CES1P1carboxylesterase 1 pseudogene 1Blood-3.340.003
15EMP1epithelial membrane protein 1Blood-3.310.031
16PCDH7protocadherin 7Blood-3.300.001
17ZAR1zygote arrest 1Blood-3.240.023
18TMEM259transmembrane protein 259Blood-3.230.047

Search GEO for disease gene expression data for Asthma.

Pathways for genes affiliated with Asthma

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Pathways related to Asthma according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.7TNF, CCL11, IL4R, IL12B, IL9, IL13
2
Show member pathways
10.7TNF, CCL11, IL4R, IL12B, IL9, IL13
3
Show member pathways
10.6IL13, IL9, IL12B, IL4R, CCL11, TNF
4
Show member pathways
10.6TNF, CCL11, IL4R, IL12B, IL9, IL13
5
Show member pathways
10.6TNF, CCL11, IL4R, IL12B, IL9, IL13
6
Show member pathways
10.6TNF, CCL11, IL4R, IL12B, IL9, IL13
7
Show member pathways
10.6TNF, IL4R, IL12B, IL13, ALOX5
8
Show member pathways
10.6HLA-G, TNF, IL12B, IL13
910.6TNF, IL12B, IL9, IL13
10
Show member pathways
Type III interferon signaling36
10.6IL4R, IL12B, IL9, IL13
1110.6IL13, IL12B, TNF
12
Show member pathways
thioredoxin pathway36
10.5TNF, ALOX5AP, ALOX5
1310.5IL13, IL9, IL4R
14
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
10.5IL9, IL4R, TNF
1510.5IL13, IL9
1610.5ALOX5, ALOX5AP
17
Show member pathways
aspirin triggered resolvin E biosynthesis36
10.5ALOX5, ALOX5AP

Compounds for genes affiliated with Asthma

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Compounds related to Asthma according to GeneCards Suite gene sharing:

(show top 50)    (show all 84)
idCompoundScoreTop Affiliating Genes
1histamine43 28 2413.2ALOX5, TNF, ADRB2, CCL11, IL4R, IL9
2dexamethasone43 49 28 1214.1HLA-G, TNF, ADRB2, CCL11, IL4R, IL13
3pge24311.1TNF, ADRB2, CCL11, IL12B, IL13, PLA2G7
4aspirin43 49 28 2414.1ADRB2, CCL11, IL13, PLA2G7, HNMT, ALOX5AP
5nitric oxide43 24 1213.1TNF, ADRB2, CCL11, IL12B, IL9, IL13
6serine4311.1SPINK5, TNF, MUC7, ADRB2, IL4R, IL9
7arachidonic acid43 28 24 1214.1TNF, ADRB2, IL4R, IL13, PLA2G7, ALOX5AP
8leukotriene b443 59 2413.1TNF, CCL11, IL13, PLA2G7, ALOX5AP, ALOX5
9cycloheximide4311.1TNF, IL4R, IL12B, IL13, PLA2G7, ALOX5AP
10montelukast43 49 28 1214.1ADRB2, CCL11, IL13, ALOX5AP, ALOX5
11rolipram43 59 2813.1TNF, ADRB2, CCL11, IL13, ALOX5
12lipid4311.1HLA-G, TNF, ADRB2, CCL11, IL12B, IL9
13rantes4311.1TNF, CCL11, IL4R, IL12B, IL9, IL13
14methacholine43 49 1213.0NPSR1, IL13, IL9, CCL11, ADRB2
15tarc4311.0TNF, CCL11, IL4R, IL9, IL13
16endotoxin4311.0PLA2G7, IL13, IL12B, CCL11, TNF
17thymidine43 2412.0TNF, ADRB2, CCL11, IL4R, IL9, IL13
18pranlukast43 28 1213.0ALOX5, ALOX5AP, CCL11, TNF
19ltc44311.0CCL11, IL13, ALOX5AP, ALOX5
20ionomycin4311.0TNF, CCL11, IL4R, IL9, IL13
21fluticasone propionate43 49 59 1214.0IL13, CCL11, ADRB2, TNF
22il 104311.0TNF, IL4R, IL12B, IL13
23sb 20358043 5912.0TNF, CCL11, IL12B, IL13, ALOX5
24indomethacin43 28 59 1214.0TNF, CCL11, IL13, ALOX5AP, ALOX5
25allergens4311.0CCL11, IL4R, IL9, IL13
26lte44310.9ALOX5, ALOX5AP, CCL11
27vegf4310.9HLA-G, TNF, ADRB2, CCL11, IL13, ALOX5
28salmeterol43 49 28 1213.9IL13, CCL11, ADRB2
29actinomycin d4310.9TNF, CCL11, IL4R, IL13, ALOX5AP
305 aminosalicylic acid4310.9TNF, IL12B, ALOX5
31il-124310.9TNF, IL12B, IL13
32indoleamine4310.9IL13, TNF, HLA-G
33groalpha4310.9IL13, CCL11, TNF
34budesonide43 49 1212.9TNF, CCL11, IL13
35fmlp4310.9TNF, CCL11, IL13, ALOX5
36sulfasalazine28 43 49 1213.9ALOX5, IL12B, TNF
37salbutamol43 49 28 24 1214.9IL13, CCL11, ADRB2
38prostaglandin4310.8TNF, CCL11, ALOX5AP, ALOX5
39ndga4310.8ALOX5, ALOX5AP, TNF
40tacrolimus43 49 1212.8TNF, CCL11, IL13, ALOX5
41pgd24310.8ALOX5, IL13, CCL11
42bw-b 70c5910.7ALOX5AP, ALOX5
43bay-x 10055910.7ALOX5AP, ALOX5
445-hydroxyeicosatetraenoic acid4310.7ALOX5AP, ALOX5
45poly(i-c)4310.7TNF, CCL11, IL12B
46peptidoglycan43 2811.6IL12B, CCL11, TNF
47n-formylmethionyl-leucylphenylalanine4310.6TNF, CCL11, ALOX5
48ccl343 2811.6IL13, CCL11, TNF
49oxygen43 2411.5HLA-G, TNF, ADRB2, CCL11, PLA2G7, ALOX5
50pentoxifylline43 1211.3IL13, IL12B, TNF

GO Terms for genes affiliated with Asthma

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Cellular components related to Asthma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:000557610.6PLA2G7, IL13, CCL11, SCGB3A2, TNF, SPINK5
2extracellular spaceGO:000561510.4ALOX5, TNF, CCL11, IL4R, IL12B, IL9

Biological processes related to Asthma according to GeneCards Suite gene sharing:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:000695410.8TNF, CCL11, IL9, IL13
2leukotriene production involved in inflammatory responseGO:000254010.8ALOX5, ALOX5AP
3lipoxin metabolic processGO:0200130010.8ALOX5, ALOX5AP
4positive regulation of macrophage activationGO:004303210.8IL13, IL4R
5immune responseGO:000695510.8IL13, IL9, IL4R, CCL11
6lipoxygenase pathwayGO:001937210.7ALOX5, ALOX5AP
7negative regulation of growth of symbiont in hostGO:004413010.7TNF, IL12B
8defense response to protozoanGO:004283210.7IL12B, IL4R
9leukotriene metabolic processGO:000669110.6ALOX5, ALOX5AP
10positive regulation of osteoclast differentiationGO:004567210.6TNF, IL12B
11positive regulation of NF-kappaB import into nucleusGO:004234610.5TNF, IL12B
12positive regulation of interleukin-12 productionGO:003273510.5IL12B, HLA-G
13positive regulation of T cell mediated cytotoxicityGO:000191610.4IL12B, HLA-G
14leukotriene biosynthetic processGO:001937010.2ALOX5, ALOX5AP

Molecular functions related to Asthma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:000512510.6IL13, IL9, IL12B, TNF

Products for genes affiliated with Asthma

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  • Antibodies
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Sources for Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet