MCID: AST005
MIFTS: 89

Asthma malady

Genetic diseases, Rare diseases, Respiratory diseases categories
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Summaries for Asthma

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MedlinePlus:33 Asthma is a chronic disease that affects your airways. your airways are tubes that carry air in and out of your lungs. if you have asthma, the inside walls of your airways become sore and swollen. that makes them very sensitive, and they may react strongly to things that you are allergic to or find irritating. when your airways react, they get narrower and your lungs get less air. symptoms of asthma include wheezing coughing, especially early in the morning or at night chest tightness shortness of breath not all people who have asthma have these symptoms. having these symptoms doesn't always mean that you have asthma. your doctor will diagnose asthma based on lung function tests, your medical history, and a physical exam. you may also have allergy tests. when your asthma symptoms become worse than usual, it's called an asthma attack. severe asthma attacks may require emergency care, and they can be fatal. asthma is treated with two kinds of medicines: quick-relief medicines to stop asthma symptoms and long-term control medicines to prevent symptoms. nih: national heart, lung, and blood institute

MalaCards based summary: Asthma, also known as chronic obstructive asthma, is related to allergic asthma and rhinitis, and has symptoms including An important gene associated with Asthma is IL13 (interleukin 13), and among its related pathways are PAK Pathway and Allograft rejection. The drugs albuterol and aminophylline and the compounds histamine and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include lung, t cells and testes, and related mouse phenotypes are immune system and respiratory system.

Disease Ontology:8 A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. the disease has symptomrecurring periods of wheezing (a whistling sound while breathing), has symptom chest tightness, has symptom shortness of breath, has symptom mucus production and has symptom coughing. the symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, excercise, stress, reflux disease, medications, foods and emotional anxiety.

Novus Biologicals:45 Asthma is a chronic lung disease that causes inflammation, thickening and narrowing of airways, as well as an overproduction of mucus. More than 300 million people worldwide suffer from asthma. Asthma symptoms include wheezing, shortness of breath, coughing and tightness of the chest. Interleukin 13 (IL-13) is the key effector cytokine in asthma. IL-13 stimulates airway fibrosis via action of matrix metalloproteinases (MMPs) on tumor transforming growth factor beta (TGN-beta), and also promotes epithelial damage, mucus production and an increased concentration of eosinophils. The inflammatory response characteristic of asthma is augmented by the production of IL-13 and other TH2 cytokines.

Wikipedia:65 Asthma (from the Greek ?????, more...

Description from OMIM:46 600807

Aliases & Classifications for Asthma

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Asthma, Aliases & Descriptions:

Name: Asthma 30 8 42 20 22 46 10 44 33 62
Chronic Obstructive Asthma 8 44 62
Bronchial Hyperreactivity 8 44 62
Chronic Obstructive Asthma with Status Asthmaticus 8 62
Bronchial Hypersensitivity 8 62
Chronic Obstructive Asthma with Acute Exacerbation 8
 
Chronic Obstructive Asthma with Exacerbation 62
Asthma, Exercise-Induced 62
Exercise Induced Asthma 8
Exercise-Induced Asthma 8
Asthma Exercise-Induced 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Respiratory diseases


Related Diseases for Asthma

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Diseases in the Asthma family:

Asthma 2 Asthma 1

Diseases related to Asthma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 415)
idRelated DiseaseScoreTop Affiliating Genes
1allergic asthma32.7IL4R, CCL11, ADAM33, ADRB2, SCGB1A1, SCGB3A2
2rhinitis32.6SCGB1A1, CCL11, IL9, IL13
3allergic rhinitis32.4CCL11, IL4R, IL13, ALOX5
4atopy32.3PLA2G7, IL4R
5eosinophilia32.2CCL11, IL9, IL13, ALOX5
6dermatitis31.9CCL11, IL13, ALOX5
7bronchiolitis31.9IL13, IL4R, CCL11
8chronic obstructive pulmonary disease31.9TNF, SCGB1A1, ADRB2, ADAM33, CCL11, IL9
9status asthmaticus31.7ADRB2
10bronchitis31.7IL9, CCL11
11pulmonary eosinophilia31.6IL13, CCL11
12food allergy31.5CCL11, IL13
13obesity31.4ALOX5, PLA2G7, CCL11, ADRB2, TNF
14atopic dermatitis31.4SPINK5, CCL11, IL13
15pneumonia31.3TNF, SCGB1A1, CCL11, IL13, PLA2G7, ALOX5AP
16eosinophilic pneumonia31.3CCL11, IL13
17arthritis31.2ALOX5, IL13, ADRB2, TNF
18respiratory failure31.2SCGB1A1, ADRB2, CCL11, IL13, ALOX5
19sinusitis31.1ALOX5, CCL11
20pulmonary sarcoidosis31.0IL9, IL12B, TNF
21tuberculosis31.0ALOX5, IL12B, IL4R, TNF
22allergic conjunctivitis30.9IL13, CCL11
23rheumatoid arthritis30.9HAVCR1, HLA-G, TNF, ADRB2, CCL11, IL4R
24esophagitis30.9CCL11, IL13
25keratoconjunctivitis30.9CCL11, IL13
26sarcoidosis30.9HLA-G, TNF, SCGB1A1, CCL11, IL12B, IL9
27vernal keratoconjunctivitis30.8CCL11, IL13
28idiopathic pulmonary fibrosis30.7SCGB1A1, IL9, IL13, ALOX5
29gamma chain deficiency30.7IL13, IL9, IL4R
30mastocytosis30.7IL13, IL9
31eosinophilic esophagitis30.6CCL11
32glioblastoma multiforme30.6ALOX5, IL13, IL4R
33malaria30.6TNF, IL12B
34hodgkin's lymphoma30.6CCL11, IL9, IL13
35atherosclerosis30.6TNF, ADRB2, CCL11, IL12B, PLA2G7, ALOX5AP
36bronchopulmonary dysplasia30.6SCGB1A1, PLA2G7
37systemic lupus erythematosus30.6TNF, ADRB2, IL4R, IL12B, PLA2G7, ALOX5
38sepsis30.6TNF, ADRB2, IL12B, PLA2G7, ALOX5
39insulin resistance30.5TNF, ADRB2, CCL11, PLA2G7
40glomerulonephritis30.5SCGB1A1, PLA2G7, ALOX5AP, ALOX5
41type 1 diabetes mellitus30.5PLA2G7, IL12B, CCL11, ADRB2
42cerebrovascular disease30.5ALOX5, ALOX5AP, PLA2G7, ADRB2
43myocardial infarction30.5ADRB2, CCL11, PLA2G7, ALOX5AP
44osteoarthritis30.4TNF, IL4R, IL12B, ALOX5AP, ALOX5
45breast cancer30.4HLA-G, SCGB1A1, CCL11, IL4R, ALOX5AP, ALOX5
46brain cancer30.4HLA-G, IL4R, IL13, ALOX5
47leukemia30.3HLA-G, TNF, SCGB1A1, CCL11, IL4R, IL12B
48lung cancer30.3HLA-G, SCGB1A1, ADRB2, IL9, ALOX5
49interstitial lung disease30.2TNF
50melanoma29.9HLA-G, TNF, CCL11, IL4R, ALOX5

Graphical network of the top 20 diseases related to Asthma:



Diseases related to asthma

Symptoms for Asthma

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Symptoms by clinical synopsis from OMIM:

600807

Clinical features from OMIM:

600807

HPO human phenotypes related to Asthma:

id Description Frequency HPO Source Accession
1 asthma HP:0002099

Drugs & Therapeutics for Asthma

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Drug clinical trials:

Search ClinicalTrials for Asthma

Search NIH Clinical Center for Asthma

Inferred drug relations via UMLS62/NDF-RT40:

Show with subtypes

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Asthma cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Asthma:
Bone marrow-derived mesenchymal stem cells for severe refractory asthma
Embryonic/Adult Cultured Cells Related to Asthma:
Mouse bone marrow-derived mesenchymal stem cells (family), PMIDs: 21653527, 20801416

Genetic Tests for Asthma

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Genetic tests related to Asthma:

id Genetic test Affiliating Genes
1 Asthma, Susceptibility to20 22 HNMT

Anatomical Context for Asthma

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MalaCards organs/tissues related to Asthma:

32
Lung, T cells, Testes, Neutrophil, Smooth muscle, Heart, Monocytes, Endothelial, Bone, Skin, B cells, Trachea, Bone marrow, Breast, Colon, Liver, Myeloid, Bronchial epithelium, Whole blood, Kidney, Thyroid, Nk cells, Lymph node, Spleen, Thymus, Brain, Skeletal muscle, Placenta, Tongue

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Asthma:
id TissueAnatomical CompartmentCell Relevance
1 LungTracheaAirway Smooth Muscle Cells Potential therapeutic candidate, affected by disease

Animal Models for Asthma or affiliated genes

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MGI Mouse Phenotypes related to Asthma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538710.6NPSR1, HAVCR1, SPINK5, HLA-G, TNF, SCGB1A1
2MP:000538810.6TNF, SCGB1A1, CCL11, IL4R, IL12B, IL13
3MP:000539710.5ADRB2, TNF, HLA-G, SPINK5, HAVCR1, CCL11
4MP:000537610.3ADRB2, SCGB1A1, TNF, HLA-G, SPINK5, IL4R

Publications for Asthma

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Articles related to Asthma:

(show top 50)    (show all 5676)
idTitleAuthorsYear
1
Nasal Il-17f Is Related To Bronchial Il-17f/Neutrophilia And Exacerbations In Stable Atopic Severe Asthma. (25394579)
2014
2
Expression and targeting of lymphocyte function-associated antigen 1 (LFA-1) on white blood cells for treatment of allergic asthma. (25341726)
2014
3
Is there a role for macrolides in severe asthma? (24247040)
2014
4
Gene-Gene Interaction Between CCR3 and Eotaxin Genes: The Relationship With Blood Eosinophilia in Asthma. (24404394)
2014
5
Cases of occupational dermatitis and asthma in beauticians that were reported to The Health and Occupation Research (THOR) network from 1996 to 2011. (24934913)
2014
6
Effects of taraxasterol on ovalbumin-induced allergic asthma in mice. (23727181)
2013
7
The effect of Qi'ao Decoction on ovalbumin induced and lipopolysaccharide enhanced severe asthma mice and its mechanism. (24345505)
2013
8
Siglec-8 and Siglec-F, the new therapeutic targets in asthma. (22324980)
2012
9
Phenotypic characterization of ex vivo CD4+CD25highCD127low immune regulatory T cells in allergic asthma: pathogenesis relevance of their FoxP3, GITR, CTLA-4 and FAS expressions. (23241113)
2012
10
Serum levels of lipoxin A(4) do not predict the development of subsequent asthma among young children with acute bronchiolitis. (21671842)
2011
11
Spirometric parameters and levels of interferon gamma and IL-5 in induced sputum from patients with allergic rhinitis or asthma. (22186238)
2011
12
Naringenin chalcone suppresses allergic asthma by inhibiting the type-2 function of CD4 T cells. (20035147)
2010
13
Disease management 360 degrees: a scorecard approach to evaluating TRICARE's programs for asthma, congestive heart failure, and diabetes. (20613658)
2010
14
Aspergillus hypersensitivity and allergic bronchopulmonary aspergillosis among asthma patients in eastern India. (21661466)
2010
15
Omalizumab reduces oral corticosteroid use in patients with severe allergic asthma: real-life data. (20599369)
2010
16
Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. (18331416)
2009
17
Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production. (18768794)
2008
18
Association of interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in Turkish children with atopic asthma. (18926055)
2008
19
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease. (18686943)
2008
20
Beta2-adrenoceptor polymorphisms and asthma phenotypes: interactions with passive smoking. (18238958)
2008
21
Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. (17373669)
2007
22
A functional CD86 polymorphism associated with asthma and related allergic disorders. (17513529)
2007
23
Granzyme B, a novel mediator of allergic inflammation: its induction and release in blood basophils and human asthma. (16794249)
2006
24
Adenovirus expressing interleukin-1 receptor antagonist alleviates allergic airway inflammation in a murine model of asthma. (16724092)
2006
25
Interleukin-13 and interleukin-5 in induced sputum of eosinophilic bronchitis: comparison with asthma. (16236836)
2005
26
Increased interleukin-4, interleukin-5, and interferon-gamma in airway CD4+ and CD8+ T cells in atopic asthma. (15502111)
2005
27
Incidence of Churg-Strauss syndrome in asthma drug users: a population-based perspective. (15940771)
2005
28
The relationship between delta-forced vital capacity (percent fall in forced vital capacity at the PC20 dose of methacholine) and the maximal airway response in patients who have mild asthma. (16450571)
2005
29
Nitric oxide synthase inhibition: therapeutic potential in asthma. (15182209)
2004
30
Plasma eotaxin level and severity of asthma treated with corticosteroid. (15303645)
2004
31
Mechanisms of action of nebulized low molecular weights heparin in patients with bronchial asthma]. (15058258)
2003
32
No linkage or association of five polymorphisms in the interleukin-4 receptor alpha gene with atopic asthma in Italian families. (14641543)
2003
33
Endogenous opioids as mediators of asthma. (11603951)
2001
34
Anti-immunoglobulin E (omalizumab) therapy in allergic asthma. (11704612)
2001
35
Management of influenza in patients with asthma or chronic obstructive pulmonary disease. (11770690)
2001
36
Rhinovirus infections: induction and modulation of airways inflammation in asthma. (10421825)
1999
37
Differential effects of endogenous and exogenous interferon-gamma on immunoglobulin E, cellular infiltration, and airway responsiveness in a murine model of allergic asthma. (9806748)
1998
38
Diisocyanate antigen-enhanced production of monocyte chemoattractant protein-1, IL-8, and tumor necrosis factor-alpha by peripheral mononuclear cells of workers with occupational asthma. (9723671)
1998
39
Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. (9482706)
1998
40
Relationship between activated eosinophils of the bronchial mucosa and serum eosinophil cationic protein in atopic asthma. (8980465)
1997
41
Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. (9487340)
1997
42
Inflammation of small airways in asthma. (9257786)
1997
43
Activation of CD4+ T cells and increased release of interleukin-5 in cultures of bronchoalveolar lavage cells and PBMC from patients with asthma]. (9387634)
1996
44
Effect of thromboxane A2-receptor antagonist on bradykinin-induced bronchoconstriction in asthma. (8806903)
1996
45
Asthma treatment in pregnancy: a randomized controlled study. (8694041)
1996
46
Allergic bronchopulmonary aspergillosis: an unusual complication of bronchial asthma. (8920604)
1995
47
Allergen-induced CD23 on CD4+ T lymphocytes and CD21 on B lymphocytes in patients with allergic asthma: evidence and regulation. (7910139)
1994
48
Comparison of the immunopathology of extrinsic, intrinsic and occupational asthma. (7874318)
1994
49
Moderating the inflammation of asthma: inhibiting the production or action of products of the 5-lipoxygenase pathway. (8129222)
1994
50
Effect of salbutamol on left ventricular function and selected biochemical parameters in patients with bronchial asthma]. (7854957)
1994

Variations for Asthma

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Clinvar genetic disease variations for Asthma:

6
id Gene Name Type Significance SNP ID Assembly Location
1TNFTNF, -308G-Asingle nucleotide variantrisk factor
2IL4RNM_000418.3(IL4R): c.1507T> C (p.Ser503Pro)single nucleotide variantPathogenicrs1805015GRCh37Chr 16, 27374180: 27374180
3IL13IL13, -1112C-Tsingle nucleotide variantrisk factor
4IL13NM_002188.2(IL13): c.431A> G (p.Gln144Arg)single nucleotide variantrisk factorrs20541GRCh37Chr 5, 131995964: 131995964
5SCGB3A2SCGB3A2, -112G/Asingle nucleotide variantrisk factor
6HNMTNM_006895.2(HNMT): c.314C> T (p.Thr105Ile)single nucleotide variantrisk factorrs11558538GRCh37Chr 2, 138759649: 138759649
7SPINK5NM_006846.3(SPINK5): c.1258A> G (p.Lys420Glu)single nucleotide variantrisk factorrs2303067GRCh37Chr 5, 147480955: 147480955
8CCL11CCL11, (GAAGGA)nundetermined variantrisk factor

Expression for genes affiliated with Asthma

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Expression patterns in normal tissues for genes affiliated with Asthma

Search GEO for disease gene expression data for Asthma.

Pathways for genes affiliated with Asthma

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Pathways related to Asthma according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.6CCL11, TNF, IL4R, IL12B, IL9, IL13
2
Show member pathways
10.6IL4R, TNF, CCL11, IL12B, IL9, IL13
3
Show member pathways
10.6TNF, CCL11, IL4R, IL12B, IL9, IL13
4
Show member pathways
10.6TNF, IL13, IL4R, IL12B, IL9, CCL11
5
Show member pathways
10.6IL9, IL13, IL12B, IL4R, CCL11, TNF
6
Show member pathways
10.6IL13, IL12B, IL4R, CCL11, TNF, IL9
7
Show member pathways
10.6IL12B, TNF, IL4R, IL13, ALOX5
8
Show member pathways
10.5HLA-G, IL13, IL12B, TNF
910.5IL12B, TNF, IL9, IL13
10
Show member pathways
Type III interferon signaling37
10.5IL9, IL12B, IL13, IL4R
1110.5TNF, IL12B, IL13
1210.5IL9, IL4R, IL13
13
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
10.5IL9, TNF, IL4R
14
Show member pathways
thioredoxin pathway37
10.5ALOX5AP, ALOX5, TNF
1510.5IL13, IL9
1610.5ALOX5, ALOX5AP
17
Show member pathways
aspirin triggered resolvin E biosynthesis37
10.5ALOX5AP, ALOX5

Compounds for genes affiliated with Asthma

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Compounds related to Asthma according to GeneCards/GeneDecks:

(show top 50)    (show all 90)
idCompoundScoreTop Affiliating Genes
1histamine44 28 2413.0IL13, IL9, IL4R, CCL11, TNF, ALOX5AP
2dexamethasone44 50 28 1114.0ADRB2, PLA2G7, ALOX5, IL4R, CCL11, TNF
3pge24411.0CCL11, IL13, PLA2G7, ALOX5, IL12B, ALOX5AP
4nitric oxide44 24 1113.0IL12B, ALOX5AP, PLA2G7, IL13, IL9, CCL11
5arachidonic acid44 28 24 1114.0TNF, ALOX5AP, SCGB1A1, ADRB2, IL4R, IL13
6aspirin44 50 28 2414.0ALOX5, PLA2G7, IL13, ADRB2, CCL11, ALOX5AP
7leukotriene b444 61 2413.0PLA2G7, ALOX5AP, ALOX5, TNF, IL13, CCL11
8lipid4411.0ALOX5AP, PLA2G7, IL9, ADRB2, IL12B, HLA-G
9endotoxin4411.0IL13, TNF, CCL11, IL12B, SCGB1A1, PLA2G7
10montelukast44 50 28 1114.0IL13, ALOX5AP, ADRB2, ALOX5, CCL11
11rantes4411.0IL4R, IL13, TNF, IL9, IL12B, CCL11
12cycloheximide4411.0IL12B, IL13, ALOX5AP, TNF, PLA2G7, IL4R
13rolipram44 61 2813.0CCL11, IL13, ALOX5, ADRB2, TNF
14tarc4411.0IL13, TNF, IL4R, IL9, CCL11
15methacholine44 50 1113.0CCL11, IL9, IL13, NPSR1, ADRB2
16pranlukast44 28 1113.0ALOX5AP, TNF, ALOX5, CCL11
17ionomycin4410.9IL13, IL9, CCL11, TNF, IL4R
18ltc44410.9CCL11, ALOX5, IL13, ALOX5AP
19thymidine44 2411.9ADRB2, IL4R, IL13, TNF, CCL11, IL9
20il 104410.9IL13, IL12B, IL4R, TNF
21fluticasone propionate44 50 61 1113.9IL13, TNF, ADRB2, CCL11
22sb 20358044 6111.9TNF, IL12B, IL13, CCL11, ALOX5
23allergens4410.9IL4R, IL9, IL13, CCL11
24oxygen44 2411.9TNF, CCL11, PLA2G7, HLA-G, SCGB1A1, ADRB2
25indomethacin44 28 61 1113.9ALOX5AP, TNF, CCL11, IL13, ALOX5
26serine4410.9IL4R, ADRB2, SPINK5, IL9, TNF, PLA2G7
27lte44410.9CCL11, ALOX5, ALOX5AP
28salmeterol44 50 28 1113.9IL13, CCL11, ADRB2
29actinomycin d4410.9ALOX5AP, TNF, CCL11, IL4R, IL13
30il-124410.9TNF, IL13, IL12B
315 aminosalicylic acid4410.9IL12B, ALOX5, TNF
32indoleamine4410.9TNF, HLA-G, IL13
33vegf4410.9TNF, ALOX5, IL13, CCL11, ADRB2, HLA-G
34groalpha4410.9TNF, IL13, CCL11
35budesonide44 50 1112.8CCL11, TNF, IL13
36sulfasalazine28 44 50 1113.8TNF, IL12B, ALOX5
37fmlp4410.8CCL11, IL13, TNF, ALOX5
38salbutamol44 50 28 24 1114.8CCL11, ADRB2, IL13
39prostaglandin4410.8CCL11, ALOX5, ALOX5AP, TNF
40ndga4410.8TNF, ALOX5AP, ALOX5
41pgd24410.7ALOX5, IL13, CCL11
42tacrolimus44 50 1112.7CCL11, IL13, ALOX5, TNF
43bw-b 70c6110.7ALOX5AP, ALOX5
44bay-x 10056110.6ALOX5AP, ALOX5
455-hydroxyeicosatetraenoic acid4410.6ALOX5AP, ALOX5
46poly(i-c)4410.6IL12B, CCL11, TNF
47peptidoglycan44 2811.5IL12B, CCL11, TNF
48pentoxifylline44 1111.5TNF, IL13, IL12B
49n-formylmethionyl-leucylphenylalanine4410.4TNF, CCL11, ALOX5
50ccl344 2811.2IL13, CCL11, TNF

GO Terms for genes affiliated with Asthma

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Cellular components related to Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.6PLA2G7, IL13, CCL11, SCGB3A2, TNF, SPINK5
2extracellular spaceGO:00561510.5ALOX5, IL13, IL9, IL12B, IL4R, CCL11
3nuclear envelopeGO:00563510.2SCGB1A1, ALOX5AP, ALOX5

Biological processes related to Asthma according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1leukotriene production involved in inflammatory responseGO:00254010.8ALOX5, ALOX5AP
2response to glucocorticoidGO:05138410.8HNMT, SCGB1A1, TNF
3inflammatory responseGO:00695410.8IL13, IL9, CCL11, TNF
4lipoxin metabolic processGO:200130010.8ALOX5, ALOX5AP
5positive regulation of macrophage activationGO:04303210.8IL4R, IL13
6immune responseGO:00695510.7CCL11, IL4R, IL9, IL13
7lipoxygenase pathwayGO:01937210.7ALOX5, ALOX5AP
8negative regulation of growth of symbiont in hostGO:04413010.7IL12B, TNF
9defense response to protozoanGO:04283210.7IL4R, IL12B
10leukotriene metabolic processGO:00669110.6ALOX5, ALOX5AP
11positive regulation of osteoclast differentiationGO:04567210.6TNF, IL12B
12positive regulation of NF-kappaB import into nucleusGO:04234610.5TNF, IL12B
13positive regulation of interleukin-12 productionGO:03273510.5IL12B, HLA-G
14positive regulation of T cell mediated cytotoxicityGO:00191610.4IL12B, HLA-G
15leukotriene biosynthetic processGO:01937010.2ALOX5, ALOX5AP

Molecular functions related to Asthma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.5IL13, IL9, IL12B, TNF

Products for genes affiliated with Asthma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Asthma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet