ASRT1
MCID: AST037
MIFTS: 29

Asthma 1 (ASRT1) malady

Categories: Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Asthma 1

Aliases & Descriptions for Asthma 1:

Name: Asthma 1 54
Asthma-Related Traits 1 66 29
Asthma-Related Traits, Susceptibility to, 1 69
Asthma, Susceptibility to, 1 13
Asrt1 66

Classifications:



External Ids:

OMIM 54 607277
MedGen 40 C1846534
MeSH 42 D001249

Summaries for Asthma 1

OMIM : 54 Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial... (607277) more...

MalaCards based summary : Asthma 1, also known as asthma-related traits 1, is related to asthma and respiratory failure. An important gene associated with Asthma 1 is PTGDR (Prostaglandin D2 Receptor). The drugs Montelukast and Prednisone have been mentioned in the context of this disorder. Affiliated tissues include testes.

UniProtKB/Swiss-Prot : 66 Asthma-related traits 1: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma 1

Diseases in the Asthma family:

Asthma 2 Asthma 1
Asthma, Phf11-Related

Diseases related to Asthma 1 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 asthma 9.9
2 respiratory failure 9.5

Symptoms & Phenotypes for Asthma 1

Clinical features from OMIM:

607277

Drugs & Therapeutics for Asthma 1

Drugs for Asthma 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 974)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 158966-92-8 5281040
2
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
3
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
4
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51333-22-3 63006 5281004
5
Procaterol Approved Phase 4,Phase 3,Phase 2,Phase 1 72332-33-3 688561
6
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 299-42-3 9294
7
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
8
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 90-82-4 7028
9
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 242138-07-4
10
Bambuterol Approved Phase 4,Phase 1 81732-65-2, 81732-46-9 54766
11
Terbutaline Approved Phase 4,Phase 3,Phase 2,Phase 1 23031-25-6 5403
12
Benzocaine Approved Phase 4,Phase 2,Phase 3,Phase 1 1994-09-7, 94-09-7 2337
13
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
14
Etomidate Approved Phase 4,Phase 2,Phase 3 33125-97-2 36339 667484
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 437-38-7 3345
16
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 1,Phase 2 59467-70-8 4192
17
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 2078-54-8 4943
18
Remifentanil Approved Phase 4 132875-61-7 60815
19
Capsaicin Approved Phase 4,Early Phase 1 404-86-4 1548943
20
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
21
Ipratropium Approved Phase 4,Phase 3,Phase 2,Phase 1 22254-24-6, 60205-81-4 43232
22
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
23
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2 26787-78-0 33613 2171
24
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 69-65-8 453 6251
25
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
26
Cilostazol Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 73963-72-1 2754
27
Everolimus Approved Phase 4,Phase 3 159351-69-6 6442177
28
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 22916-47-8 4189
29
Sirolimus Approved, Investigational Phase 4,Phase 3 53123-88-9 5284616 6436030 46835353
30
Ticlopidine Approved Phase 4,Phase 3,Phase 2,Phase 1 55142-85-3 5472
31
Carvedilol Approved, Investigational Phase 4,Phase 1 72956-09-3 2585
32
Metoprolol Approved, Investigational Phase 4,Phase 2,Phase 1 37350-58-6, 51384-51-1 4171
33
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-02-2 5743
34
Atropine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 5908-99-6, 51-55-8 174174
35
Tropicamide Approved Phase 4,Phase 1 1508-75-4 5593
36
Succinylcholine Approved Phase 4,Phase 2 306-40-1 5314
37
Epoprostenol Approved Phase 4,Phase 3 61849-14-7, 35121-78-9 5280427 5282411
38
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83881-51-0 2678
39
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Phase 1 103-90-2 1983
40
Aminocaproic Acid Approved, Investigational Phase 4 60-32-2 564
41
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 137-58-6 3676
42
Biperiden Approved Phase 4 514-65-8 2381
43
Diazepam Approved, Illicit, Vet_approved Phase 4,Phase 3,Phase 1 439-14-5 3016
44
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
45
Droperidol Approved, Vet_approved Phase 4 548-73-2 3168
46
Lorazepam Approved Phase 4 846-49-1 3958
47
Oxymetazoline Approved Phase 4,Phase 3,Phase 2,Phase 1 1491-59-4 4636
48
Phenylephrine Approved Phase 4,Phase 3,Phase 2,Phase 1 59-42-7 6041
49
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 2216-51-5 16666
50
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 100643-71-8 124087

Interventional clinical trials:

(show top 50) (show all 4123)
id Name Status NCT ID Phase
1 Effects of Montelukast in Asthmatic Children With and Without Food Allergy Unknown status NCT01618929 Phase 4
2 Rapid Onset Action of Salbutamol Versus Formoterol Unknown status NCT00900874 Phase 4
3 Vitamin D for the Treatment of Severe Asthma Unknown status NCT00712205 Phase 4
4 A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control Unknown status NCT00385359 Phase 4
5 Inflammatory, Functional and Image Composite Measure to Define Asthma Control Unknown status NCT00597064 Phase 4
6 Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma Unknown status NCT00500253 Phase 4
7 Efficacy and Safety of Activation Energy Serum (AES) Versus Placebo in Persistent Asthma. Unknown status NCT01939951 Phase 4
8 Assessing Decision Maker Tools for Asthma: the Asthma APGAR Unknown status NCT01446315 Phase 4
9 Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4
10 A Comparison of Mometasone to Advair in Patients With Milder Persistent Asthma Unknown status NCT00461812 Phase 4
11 Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma Unknown status NCT00496574 Phase 4
12 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4
13 Effect of Specific Immunotherapy to Dust Mites in Children With Asthma Unknown status NCT00496561 Phase 4
14 Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma Unknown status NCT00830505 Phase 4
15 A Pilot Study Involving an Asthma Management Program for Inner-city Early Head Start Children Unknown status NCT00624429 Phase 4
16 Optimization of Inhaled Corticosteroid Treatment in Adult Patients With Asthma Guided by Exhaled NO Measurement at Home Unknown status NCT01783132 Phase 4
17 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4
18 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4
19 mRNA Expression as a Biomarker of Omalizumab Response Unknown status NCT01584687 Phase 4
20 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4
21 Predicting the Clinical Response to Omalizumab With Anti-IgE Ab Response or Syk Expression in Basophils Unknown status NCT02023151 Phase 4
22 Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia Unknown status NCT02289391 Phase 4
23 Comparing Fluticasone-Salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep Unknown status NCT00731770 Phase 4
24 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4
25 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4
26 Mechanism(s)of Airflow Limitation in Moderate-severe Persistent Asthma Unknown status NCT00576069 Phase 4
27 POLlinosis and Exhaled Breath Temperature Unknown status NCT01785394 Phase 4
28 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4
29 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4
30 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4
31 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4
32 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4
33 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4
34 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Unknown status NCT02371941 Phase 4
35 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4
36 Inhaled Salbutamol in Elective Caesarean Section Unknown status NCT01978418 Phase 4
37 Comparing Treatment Efficacy With HD/MD Flu Plus Sal in Chronic Obstructive Pulmonary Disease (COPD) Patients Unknown status NCT01131806 Phase 4
38 Intravenous Terbutaline to Facilitate Labor Epidural Catheter Placement Unknown status NCT01651962 Phase 4
39 Predictor for an Additional Benefit of Inhaled Corticosteroid in Patients Treated With Tiotropium for COPD Unknown status NCT00860938 Phase 4
40 Can Advair and Flovent Reduce Systemic Inflammation Related to Chronic Obstructive Pulmonary Disease (COPD)? A Multi-Center Randomized Controlled Trial Unknown status NCT00120978 Phase 4
41 The Efficacy and Safety of Salmeterol/Fluticasone Propionate vs Atropium/Albuterol in Patients COPD Unknown status NCT01243788 Phase 4
42 Sufficient Treatment of Peripheral Intervention by Cilostazol Unknown status NCT00912756 Phase 4
43 Efficacy and Safety of add-on Montelukast to Inhaled Budesonide in the Treatment of Nonasthmatic Eosinophilic Bronchitis Unknown status NCT01121016 Phase 4
44 Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis - SAfety & EffectiveneSS of Drug-ElUting Stents & Anti-platelet REgimen Unknown status NCT01267734 Phase 4
45 Comparing Treatment Efficacy With High and Medium Dose of Fluticasone in Combination With Salmeterol in COPD Patients Unknown status NCT01657487 Phase 4
46 Singulair Use in Non-Allergic Rhinitis Eosinophil Syndrome (NARES) Unknown status NCT00406094 Phase 4
47 Coreg CR, Blood Vessel Stiffness and Blood Vessel Function Unknown status NCT00732511 Phase 4
48 Nebulized 3% Hypertonic Saline in the Treatment of Acute Bronchiolitis in the Emergency Department Unknown status NCT01660867 Phase 4
49 Study of Myopia Prevention in Children With Low Concentration of Atropine Unknown status NCT00541177 Phase 4
50 Atropine Versus no Atropine for Neonatal Rapid Sequence Intubation Unknown status NCT01595399 Phase 4

Search NIH Clinical Center for Asthma 1

Genetic Tests for Asthma 1

Genetic tests related to Asthma 1:

id Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 1 29

Anatomical Context for Asthma 1

MalaCards organs/tissues related to Asthma 1:

39
Testes

Publications for Asthma 1

Articles related to Asthma 1:

id Title Authors Year
1
A 47-year-old woman with severe asthma, 1 year later. ( 11466125 )
2001
2
Adherence and compliance in the management of asthma: 1. ( 10076205 )
1998
3
Practical aspects of aerosol therapy in asthma (1) ( 9141764 )
1996
4
Asthma: 1. Pathophysiologic features and evaluation of severity. ( 3815196 )
1987
5
Duration of the development stages of house dust mites Dermatophagoides farinae and D. pteronyssinus under controlled temperatures and relative humidities to pave the way in front of the workers in the field of house-dust mite bronchial asthma. 1. Pre-imaginal period. ( 6663096 )
1983
6
Management of asthma. 1. Approach. ( 854495 )
1977
7
Acute respiratory failure due to asthma. 1. Pathophysiology. ( 5566205 )
1971

Variations for Asthma 1

ClinVar genetic disease variations for Asthma 1:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PTGDR PTGDR, HAPLOTYPE TCT undetermined variant risk factor
2 PTGDR PTGDR, HAPLOTYPE CCC undetermined variant risk factor

Expression for Asthma 1

Search GEO for disease gene expression data for Asthma 1.

Pathways for Asthma 1

GO Terms for Asthma 1

Sources for Asthma 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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