MCID: AST037
MIFTS: 33

Asthma 1

Categories: Genetic diseases, Rare diseases, Respiratory diseases

Aliases & Classifications for Asthma 1

MalaCards integrated aliases for Asthma 1:

Name: Asthma 1 54
Asthma-Related Traits, Susceptibility to, 1 29 69
Asthma, Susceptibility to, 1 13
Asthma-Related Traits 1 71
Asrt1 71

Classifications:



External Ids:

OMIM 54 607277
MedGen 40 C1846534
MeSH 42 D001249

Summaries for Asthma 1

OMIM : 54
Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, and dyspnea; bronchial hyperresponsiveness (BHR) as assessed by methacholine challenge test; serum IgE levels; atopy; and atopic dermatitis (Laitinen et al., 2001; Illig and Wjst, 2002; Pillai et al., 2006). For a general phenotypic description and a discussion of genetic heterogeneity of asthma, see 600807. (607277)

MalaCards based summary : Asthma 1, also known as asthma-related traits, susceptibility to, 1, is related to asthma and glycogen storage disease vi. An important gene associated with Asthma 1 is PTGDR (Prostaglandin D2 Receptor). The drugs Prednisone and Adenosine have been mentioned in the context of this disorder. Affiliated tissues include lung, testes and heart.

UniProtKB/Swiss-Prot : 71 Asthma-related traits 1: Asthma-related traits include clinical symptoms of asthma, such as coughing, wheezing, dyspnea, bronchial hyperresponsiveness as assessed by methacholine challenge test, serum IgE levels, atopy and atopic dermatitis.

Related Diseases for Asthma 1

Diseases in the Asthma family:

Asthma 2 Asthma 1

Diseases related to Asthma 1 via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 asthma 9.9
2 glycogen storage disease vi 9.5 CHRM1 PTGDR
3 respiratory failure 9.5

Symptoms & Phenotypes for Asthma 1

Clinical features from OMIM:

607277

Drugs & Therapeutics for Asthma 1

Drugs for Asthma 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 756)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 53-03-2 5865
2
Adenosine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 58-61-7 60961
3
Budesonide Approved Phase 4,Phase 3,Phase 2,Phase 1 51333-22-3 63006 5281004
4
Nitric Oxide Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 10102-43-9 145068
5
Procaterol Approved Phase 4,Phase 3,Phase 2,Phase 1 72332-33-3 688561
6
Ephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 299-42-3 9294
7
Guaifenesin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 93-14-1 3516
8
Pseudoephedrine Approved Phase 4,Phase 3,Phase 2,Phase 1 90-82-4 7028
9
Montelukast Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 158966-92-8 5281040
10
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1 242138-07-4
11
Bambuterol Approved Phase 4 81732-65-2, 81732-46-9 54766
12
Terbutaline Approved Phase 4,Phase 3,Phase 2,Phase 1 23031-25-6 5403
13
Benzocaine Approved Phase 4,Phase 2,Phase 3 1994-09-7, 94-09-7 2337
14
Dexmedetomidine Approved, Vet_approved Phase 4 76631-46-4, 113775-47-6 68602 5311068 56032
15
Etomidate Approved Phase 4 33125-97-2 36339 667484
16
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 437-38-7 3345
17
Midazolam Approved, Illicit Phase 4,Phase 1,Phase 2 59467-70-8 4192
18
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 2078-54-8 4943
19
Remifentanil Approved Phase 4 132875-61-7 60815
20
Capsaicin Approved Phase 4,Early Phase 1 404-86-4 1548943
21
Epinephrine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 51-43-4 5816
22 Racepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1
23
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 75614-87-8, 51-45-6 774
24
Azelastine Approved Phase 4,Phase 3 58581-89-8 2267
25
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83-43-2 6741
26
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 50-24-8 5755
27
Xylometazoline Approved Phase 4 526-36-3 5709
28
Amoxicillin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Early Phase 1 26787-78-0 33613 2171
29
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 2216-51-5 16666
30
Levocetirizine Approved Phase 4,Phase 3,Phase 2 130018-77-8
31
Ciclesonide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 126544-47-6, 141845-82-1 444033
32
Ipratropium Approved Phase 4,Phase 3,Phase 2,Phase 1 22254-24-6, 60205-81-4 43232
33
Azithromycin Approved Phase 4,Phase 3,Phase 1,Phase 2 83905-01-5 55185 53477736 447043
34
Citalopram Approved Phase 4 59729-33-8 2771
35
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-23-7 5754 657311
36
Propranolol Approved, Investigational Phase 4,Phase 2,Phase 1 525-66-6 4946
37
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 50-78-2 2244
38
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2,Early Phase 1 137-58-6 3676
39
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
40
Atropine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 5908-99-6, 51-55-8 174174
41
Bupivacaine Approved, Investigational Phase 4,Phase 1,Phase 2,Early Phase 1 2180-92-9, 38396-39-3 2474
42
Cetirizine Approved Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 83881-51-0 2678
43
Desloratadine Approved, Investigational Phase 4,Phase 3,Phase 2 100643-71-8 124087
44
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
45
Lamotrigine Approved, Investigational Phase 4 84057-84-1 3878
46
Carbamazepine Approved, Investigational Phase 4 298-46-4 2554
47
Oxcarbazepine Approved Phase 4 28721-07-5 34312
48
Valproic Acid Approved, Investigational Phase 4 99-66-1 3121
49
Varenicline Approved, Investigational Phase 4 249296-44-4 5310966
50
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Early Phase 1 69-65-8 453 6251

Interventional clinical trials:

(show top 50) (show all 2804)

id Name Status NCT ID Phase Drugs
1 Rapid Onset Action of Salbutamol Versus Formoterol Unknown status NCT00900874 Phase 4 salbutamol;Formoterol
2 Vitamin D for the Treatment of Severe Asthma Unknown status NCT00712205 Phase 4 Placebo;Calcitriol
3 A Pilot Efficacy Study of Inhaled Albuterol Delivered With Akita Breath Control Unknown status NCT00385359 Phase 4 Albuterol
4 Inflammatory, Functional and Image Composite Measure to Define Asthma Control Unknown status NCT00597064 Phase 4 prednisone
5 Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics Unknown status NCT02574975 Phase 4 methacholine;adenosine monophosphate;leukotriene D4;budesonide /formoterol
6 Assessment of Utility of Exhaled Nitric Oxide Measurement for Treatment Monitoring in Children With Asthma Unknown status NCT00500253 Phase 4
7 Efficacy and Safety of Activation Energy Serum (AES) Versus Placebo in Persistent Asthma. Unknown status NCT01939951 Phase 4
8 Assessing Decision Maker Tools for Asthma: the Asthma APGAR Unknown status NCT01446315 Phase 4
9 Efficacy and Safety Study of Procaterol Hydrochloride to Treat Patients With Cough Variant Asthma (CVA) Unknown status NCT01170429 Phase 4 Procaterol hydrochloride;Meptin placebo
10 Evaluation of Efficacy of House Dust Mite Immunotherapy in Children With Bronchial Asthma Unknown status NCT00496574 Phase 4
11 Assessment of Sublingual Immunotherapy in Children Allergic to House Dust Mites Unknown status NCT01052610 Phase 4 sublingual house dust mites allergen extract;placebo in sublingual applicator
12 Effect of Specific Immunotherapy to Dust Mites in Children With Asthma Unknown status NCT00496561 Phase 4
13 Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma Unknown status NCT00830505 Phase 4 fluticasone/ salmeterol;fluticasone
14 A Pilot Study Involving an Asthma Management Program for Inner-city Early Head Start Children Unknown status NCT00624429 Phase 4 Budesonide respules
15 Optimization of Inhaled Corticosteroid Treatment in Adult Patients With Asthma Guided by Exhaled NO Measurement at Home Unknown status NCT01783132 Phase 4
16 Effects of Su-Huang Antitussive Capsule on Cough Variant Asthma Unknown status NCT01584804 Phase 4 Su-Huang antitussive capsule;Sugar pill
17 Effects of Leukotriene Modulator Montelukast on Cough Variant Asthma Unknown status NCT01404013 Phase 4 ICS/LABA;Montelukast;ICS/LABA and Montelukast
18 mRNA Expression as a Biomarker of Omalizumab Response Unknown status NCT01584687 Phase 4
19 The Effect of Bronchodilator on Eosinophilic Bronchitis and Cough Variant Asthma Unknown status NCT02002754 Phase 4 Bambuterol Hydrochloride tablets
20 Predicting the Clinical Response to Omalizumab With Anti-IgE Ab Response or Syk Expression in Basophils Unknown status NCT02023151 Phase 4 Omalizumab;Placebo injection
21 Effect of Dexmedetomidine on Levels of Plasma Inflammatory Factor in Asthma Patients Undergoing General Anesthesia Unknown status NCT02289391 Phase 4 Anesthesia induction;Anesthesia maintenance;Assisted anesthesia
22 Comparing Fluticasone-Salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep Unknown status NCT00731770 Phase 4 fluticasone/salmeterol 250/50;placebo
23 Comparative Study of Sinol and Sinol-M in Patients With Congestion Due to Allergic Rhinitis Unknown status NCT00825656 Phase 4 Sinol or Sinol-M nasal spray
24 Bronchiolitis All-study, SE-Norway Unknown status NCT00817466 Phase 4 Racemic adrenaline;Isotonic saline
25 POLlinosis and Exhaled Breath Temperature Unknown status NCT01785394 Phase 4 5 grass allergen extract
26 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
27 Montelukast for Persistent Cough in Young People and Adults Unknown status NCT01279668 Phase 4 Montelukast;Placebo
28 Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 Mcg BID Unknown status NCT00235053 Phase 4 fluticasone/salmeterol DISKUS 250/50
29 4"S" - Seasonal Symptoms Suppression Study Unknown status NCT02557269 Phase 4 Xylometazoline - intranasal application;Azelastine - intranasal application;Mometasone furoate - intranasal application;Hydroxyl-propyl-methyl cellulose powder - intranasal application;Bilastine 20 mg;Prednisolone 5 mg
30 Evaluate the Effects of Formoterol and Beclomethasone Dipropionate Combination Therapy on Small Airways Function Unknown status NCT01466712 Phase 4 Tiotropium + formoterol/beclometasone;tiotropium + placebo
31 Comparison of Daily Mometasone Furoate Nasal Spray Alone Versus a Combination With Montelukast for Treatment of Chronic Rhinosinusitis With Asthma After Functional Endoscopic Sinus Surgery Unknown status NCT02110654 Phase 4 Montelukast;mometasone furoate nasal spray
32 Middle Meatal Bacteriology During Acute Respiratory Infection in Children Unknown status NCT00545961 Phase 4 placebo;amoxicillin clavulanate acid
33 Oral Cromolyn Sodium for the Treatment of Eosinophilic Esophagitis Unknown status NCT02371941 Phase 4 oral cromolyn sodium;Placebo
34 The Effect of Xolair on Inhibiting Leukotriene and Cytokine (IL-4 and IL-13) Release From Blood Basophils Unknown status NCT00673218 Phase 4 Placebo;Xolair
35 Inhaled Salbutamol in Elective Caesarean Section Unknown status NCT01978418 Phase 4 salbutamol;Placebo
36 A Non-inferiority Study to Evaluate Efficacy, Safety and Tolerability of NEUMOTEROL® 400 and SYMBICORT® Forte in Adults With Asthma Completed NCT02233803 Phase 4 NEUMOTEROL 400 (BFF 400/12 mcg) single capsule inhaler;SYMBICORT forte (BFF 320/9mcg) TURBUHALER inhaler;NEUMOTEX 400 (Budesonide 400 mcg);Salbutamol 100 mcg pMDI
37 Effect of Montelukast on Remodelling Markers in Asthmatic Children Completed NCT00875082 Phase 4 Montelukast;placebo
38 Crossover Study Comparing Fluticasone Furoate (FF)/Vilanterol (VI) Once Daily Versus Fluticasone Propionate (FP) Twice Daily in Subjects With Asthma and Exercise-Induced Bronchoconstriction (EIB) Completed NCT02730351 Phase 4 Fluticasone furoate/ Vilanterol 100 mcg/25 mcg;Fluticasone propionate 250 mcg;Placebo via ELLIPTA inhaler;Placebo via DISKUS / ACCUHALER
39 Efficacy and Safety of Fluticasone Propionate(FP)/ Salmeterol Xinafoate (SLM) Hydro Fluoro Alkane (HFA) Metered Dose Inhaler (MDI) in Pediatric Patients With Bronchial Asthma Completed NCT02113436 Phase 4 FP/ SLM HFA MDI 50/25 mcg;FP HFA MDI 50 mcg
40 Inhaled Steroid Treatment as Regular Therapy in Early Asthma Completed NCT00641914 Phase 4 budesonide;Placebo
41 MethaCholine Bronchoprovocation Study (MeCIS) Completed NCT00705341 Phase 4 fluticasone
42 Effects of Montelukast in Asthmatic Children With and Without Food Allergy Completed NCT01618929 Phase 4 Montelukast
43 Comparison of Single-Dose Efficacy of an Albuterol Breath Activated Inhaler (Albuterol-HFA-BAI) Versus an Albuterol Metered Dose Inhaler (HFA-MDI) (Both Using the Same Hydrofluoroalkane Propellant) in Asthmatics Completed NCT00530062 Phase 4 Albuterol-HFA-MDI;Albuterol-HFA-BAI
44 Anti-inflammatory H1 Antihistamines Allergic Rhinitis Completed NCT02507635 Phase 4 Levocetirizine;Desloratadine
45 Albuterol Versus Xopenex in Treatment of Acute Asthma in the Emergency Department (ED) Completed NCT00585039 Phase 4 xopenex
46 Study of Efficacy of Gabapentin in Therapy of Bronchial Asthma Completed NCT00153283 Phase 4 Gabapentin
47 Study of Efficacy of Lamotrigine in Therapy of Bronchial Asthma Completed NCT00153244 Phase 4 Lamotrigine
48 Study of Efficacy of Oxcarbazepine in Therapy of Bronchial Asthma Completed NCT00142025 Phase 4 Oxcarbazepine
49 Study of Efficacy of Sodium Valproate in Therapy of Bronchial Asthma Completed NCT00153270 Phase 4 Sodium Valproate
50 Study of Efficacy of Carbamazepine in Therapy of Patients With Moderate Persistent and Severe Bronchial Asthma Completed NCT00153296 Phase 4 Carbamazepine

Search NIH Clinical Center for Asthma 1

Genetic Tests for Asthma 1

Genetic tests related to Asthma 1:

id Genetic test Affiliating Genes
1 Asthma-Related Traits, Susceptibility to, 1 29

Anatomical Context for Asthma 1

MalaCards organs/tissues related to Asthma 1:

39
Lung, Testes, Heart, Skin, T Cells, Neutrophil, Breast

Publications for Asthma 1

Articles related to Asthma 1:

id Title Authors Year
1
A 47-year-old woman with severe asthma, 1 year later. ( 11466125 )
2001
2
Adherence and compliance in the management of asthma: 1. ( 10076205 )
1998
3
Practical aspects of aerosol therapy in asthma (1) ( 9141764 )
1996
4
Asthma: 1. Pathophysiologic features and evaluation of severity. ( 3815196 )
1987
5
Duration of the development stages of house dust mites Dermatophagoides farinae and D. pteronyssinus under controlled temperatures and relative humidities to pave the way in front of the workers in the field of house-dust mite bronchial asthma. 1. Pre-imaginal period. ( 6663096 )
1983
6
Management of asthma. 1. Approach. ( 854495 )
1977
7
Acute respiratory failure due to asthma. 1. Pathophysiology. ( 5566205 )
1971

Variations for Asthma 1

ClinVar genetic disease variations for Asthma 1:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 PTGDR PTGDR, HAPLOTYPE TCT undetermined variant risk factor
2 PTGDR PTGDR, HAPLOTYPE CCC undetermined variant risk factor

Expression for Asthma 1

Search GEO for disease gene expression data for Asthma 1.

Pathways for Asthma 1

GO Terms for Asthma 1

Biological processes related to Asthma 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor signaling pathway GO:0007186 8.62 CHRM1 PTGDR

Molecular functions related to Asthma 1 according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 8.96 CHRM1 PTGDR
2 signal transducer activity GO:0004871 8.62 CHRM1 PTGDR

Sources for Asthma 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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