MCID: AST020
MIFTS: 26

Asthma and Nasal Polyps malady

Summaries for Asthma and Nasal Polyps

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46OMIM, 32MalaCards
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MalaCards: Asthma and Nasal Polyps is related to multiple sclerosis and rhinitis. An important gene associated with Asthma and Nasal Polyps is TBX21 (T-box 21), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Development VEGF signaling via VEGFR2 - generic cascades. The compounds Salicylate-sodium and dup 697 have been mentioned in the context of this disorder. Related mouse phenotypes are tumorigenesis and respiratory system.

Description from OMIM:46 208550

Aliases & Classifications for Asthma and Nasal Polyps

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46OMIM
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Aliases & Descriptions:

asthma and nasal polyps 46


Related Diseases for Asthma and Nasal Polyps

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17GeneCards, 18GeneDecks
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Diseases related to Asthma and Nasal Polyps via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 18)
idRelated DiseaseScoreTop Affiliating Genes
1multiple sclerosis10.0TBX21
2rhinitis10.0PTGS1
3pleurisy10.0PTGS2
4ureteral obstruction10.0PTGS1
5cervical cancer10.0PTGS2
6gastroesophageal reflux disease10.0PTGS1
7stomach disease10.0PTGS2, PTGS1
8urticaria10.0PTGS2, PTGS1
9gastritis10.0PTGS2, PTGS1
10rheumatoid arthritis10.0PTGS2, PTGS1
11arthritis10.0PTGS2, PTGS1
12barrett's esophagus10.0PTGS2, PTGS1
13rheumatic disease10.0PTGS2, PTGS1
14angioedema10.0PTGS1, PTGS2
15polycythemia vera10.0IL3
16peptic ulcer10.0PTGS2, PTGS1
17gastric ulcer10.0PTGS1, PTGS2
18asthma10.0IL3, PTGS1, TBX21

Graphical network of diseases related to Asthma and Nasal Polyps:



Diseases related to asthma and nasal polyps

Clinical Features for Asthma and Nasal Polyps

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46OMIM
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Clinical features from OMIM:

208550

Drugs & Therapeutics for Asthma and Nasal Polyps

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Asthma and Nasal Polyps

Drug clinical trials:

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Search NIH Clinical Center for Asthma and Nasal Polyps

Search CenterWatch for Asthma and Nasal Polyps

Genetic Tests for Asthma and Nasal Polyps

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Anatomical Context for Asthma and Nasal Polyps

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Animal Models for Asthma and Nasal Polyps or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Asthma and Nasal Polyps:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.1TBX21
2MP:00053888.1PTGS2, PTGS1, IL3, TBX21
3MP:00053798.0TBX21, IL3, PTGS1, PTGS2
4MP:00053848.0PTGS2, PTGS1, IL3, TBX21
5MP:00053977.9TBX21, IL3, PTGS1, PTGS2
6MP:00053877.7TBX21, IL3, PTGS1, PTGS2

Publications for Asthma and Nasal Polyps

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Genetic Variations for Asthma and Nasal Polyps

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Expression for genes affiliated with Asthma and Nasal Polyps

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Asthma and Nasal Polyps

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Pathways for genes affiliated with Asthma and Nasal Polyps

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49PharmGKB, 12EMD Millipore, 53Reactome, 29KEGG, 4Cell Signaling Technology, 37NCBI BioSystems Database, 51QIAGEN
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Compounds for genes affiliated with Asthma and Nasal Polyps

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11DrugBank, 44Novoseek, 24HMDB, 28IUPHAR, 59Tocris Bioscience, 49PharmGKB
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Compounds related to Asthma and Nasal Polyps according to GeneCards/GeneDecks:

(show top 50)    (show all 102)
idCompoundScoreTop Affiliating Genes
1Salicylate-sodium119.8PTGS2, PTGS1
2dup 697449.8PTGS1, PTGS2
3loxoprofen449.8PTGS2, PTGS1
4mofezolac449.8PTGS2, PTGS1
5bromfenac44 1110.8PTGS1, PTGS2
6salsalate44 1110.8PTGS1, PTGS2
7Prostaglandin G211 2410.8PTGS2, PTGS1
8Tiaprofenic acid119.8PTGS2, PTGS1
9flosulide449.8PTGS2, PTGS1
10Antrafenine119.8PTGS1, PTGS2
11Trisalicylate-choline119.8PTGS1, PTGS2
12Nepafenac119.8PTGS1, PTGS2
13aceclofenac449.8PTGS2, PTGS1
14gamma-Homolinolenic acid119.7PTGS1, PTGS2
15Magnesium salicylate119.7PTGS2, PTGS1
16diclofenac sodium449.7PTGS1, PTGS2
17oxaprozin44 1110.7PTGS1, PTGS2
18lornoxicam44 1110.7PTGS2, PTGS1
19parecoxib44 28 1111.7PTGS1, PTGS2
20licofelone449.7PTGS1, PTGS2
2115-hydroperoxyeicosatetraenoic acid449.7PTGS1, PTGS2
22sc 5812544 5910.7PTGS1, PTGS2
23r-flurbiprofen449.7PTGS1, PTGS2
24carprofen44 1110.7PTGS2, PTGS1
25tenoxicam44 1110.7PTGS2, PTGS1
26fenoprofen28 44 1111.7PTGS2, PTGS1
27ketorolac44 1110.7PTGS1, PTGS2
28balsalazide44 1110.7PTGS2, PTGS1
29lumiracoxib44 28 1111.7PTGS2, PTGS1
30nabumetone44 1110.7PTGS2, PTGS1
31tolmetin44 1110.7PTGS1, PTGS2
32Mesalazine119.7PTGS1, PTGS2
33meclofenamic acid44 1110.7PTGS1, PTGS2
34etoricoxib44 28 1111.6PTGS2, PTGS1
35valdecoxib44 28 11 2412.6PTGS1, PTGS2
36diflunisal44 1110.6PTGS2, PTGS1
37mefenamic acid44 28 1111.6PTGS1, PTGS2
38Acetylsalicylic acid119.6PTGS2, PTGS1
3911-deoxy-pge1449.6PTGS2, PTGS1
40suprofen44 1110.5PTGS2, PTGS1
41Icosapent119.5PTGS1, PTGS2
42prostaglandin-h2449.5PTGS1, PTGS2
43meloxicam44 1110.4PTGS2, PTGS1
44Salicyclic acid119.4PTGS2, PTGS1
45tramadol44 49 1111.3PTGS1, PTGS2
46nimesulide44 1110.3PTGS2, PTGS1
47phenylbutazone44 1110.0PTGS2, PTGS1
48lenalidomide44 1110.0PTGS2, IL3
49herbimycin a44 599.8IL3, PTGS2, PTGS1
50prostacyclin448.7IL3, PTGS2, PTGS1

GO Terms for genes affiliated with Asthma and Nasal Polyps

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16Gene Ontology
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Biological processes related to Asthma and Nasal Polyps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cyclooxygenase pathwayGO:0193719.4PTGS2, PTGS1
2prostaglandin biosynthetic processGO:0015169.3PTGS2, PTGS1
3response to oxidative stressGO:0069799.3PTGS2, PTGS1
4arachidonic acid metabolic processGO:0193699.2PTGS1, PTGS2
5regulation of blood pressureGO:0082179.0PTGS2, PTGS1

Molecular functions related to Asthma and Nasal Polyps according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1heme bindingGO:0200379.3PTGS2, PTGS1
2prostaglandin-endoperoxide synthase activityGO:0046669.2PTGS2, PTGS1
3peroxidase activityGO:0046019.0PTGS2, PTGS1

Products for genes affiliated with Asthma and Nasal Polyps

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Sources for Asthma and Nasal Polyps

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet