MCID: AST038
MIFTS: 28

Asthma, Aspirin-Induced malady

Categories: Genetic diseases (common), Respiratory diseases

Aliases & Classifications for Asthma, Aspirin-Induced

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Aliases & Descriptions for Asthma, Aspirin-Induced:

Name: Asthma, Aspirin-Induced 52 39
Asthma and Nasal Polyps 52 70 12
Asthma, with Nasal Polyps and Aspirin Intolerance 70 27
Asthma, Nasal Polyps, and Aspirin Intolerance 68
Nasal Polyps Asthma and Aspirin Sensitivity 70
Aspirin-Intolerant Asthma 70
 
Asthma Aspirin-Induced 70
Samter Triad 70
Asa Triad 70
Anpai 70
Aia 70

Characteristics:

HPO:

64
asthma, aspirin-induced:
Inheritance: autosomal recessive inheritance

Classifications:



External Ids:

OMIM52 208550
MeSH39 D055963
ICD1030 J45.9

Summaries for Asthma, Aspirin-Induced

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UniProtKB/Swiss-Prot:70 Asthma, with nasal polyps and aspirin intolerance: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.

MalaCards based summary: Asthma, Aspirin-Induced, also known as asthma and nasal polyps, is related to asthma and cataract 32, multiple types, and has symptoms including asthma, aspirin-induced asthma and nasal polyposis. An important gene associated with Asthma, Aspirin-Induced is TBX21 (T-Box 21). Affiliated tissues include t cells and testes, and related mouse phenotypes are Increased shRNA abundance (Z-score > 2) and neoplasm.

Wikipedia:71 Aspirin-induced asthma, also termed Samter\'s triad, Samter\'s syndrome, aspirin-exacerbated respiratory... more...

Description from OMIM:52 208550

Related Diseases for Asthma, Aspirin-Induced

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Diseases related to Asthma, Aspirin-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1asthma10.0
2cataract 32, multiple types9.5PTGER2, TBX21

Symptoms & Phenotypes for Asthma, Aspirin-Induced

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Symptoms by clinical synopsis from OMIM:

208550

Clinical features from OMIM:

208550

Human phenotypes related to Asthma, Aspirin-Induced:

 64
id Description HPO Frequency HPO Source Accession
1 asthma64 HP:0002099
2 aspirin-induced asthma64 HP:0012042
3 nasal polyposis64 HP:0100582

GenomeRNAi Phenotypes related to Asthma, Aspirin-Induced according to GeneCards Suite gene sharing:

26
idDescriptionGenomeRNAi Source AccessionScoreTop Affiliating Genes
1GR00366-A-359.9PTGER2, TBX21

MGI Mouse Phenotypes related to Asthma, Aspirin-Induced according to GeneCards Suite gene sharing:

41
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.8PTGER2, TBX21
2MP:00053889.1PTGER2, TBX21

Drugs & Therapeutics for Asthma, Aspirin-Induced

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Drugs for Asthma, Aspirin-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Aspirinapproved, vet_approvedPhase 4, Phase 3, Phase 2111250-78-22244
Synonyms:
11126-35-5
11126-37-7
1oxr
2-(ACETYLOXY)benzoic acid
2-(Acetyloxy)benzoate
2-(Acetyloxy)benzoic acid
2-Acetoxybenzenecarboxylic acid
2-Acetoxybenzoate
2-Acetoxybenzoic acid
2-Carboxyphenyl acetate
2349-94-2
26914-13-6
50-78-2
8-hour Bayer
98201-60-6
A 5376
A.S.A
A.S.A.
A.S.A. Empirin
A.S.A. empirin
A2093_SIGMA
A3160_SIGMA
A5376_SIGMA
A6810_SIGMA
AB1003266
AC 5230
AC1L1D8U
AC1Q1LA0
ACETYLSALICYLIC ACID
AI3-02956
AIN
AKOS000118884
ASA
Acenterine
Acesal
Acetal
Acetard
Aceticyl
Acetilsalicilico
Acetilum acidulatum
Acetisal
Acetol
Acetonyl
Acetophen
Acetosal
Acetosalic acid
Acetosalin
Acetoxybenzoic acid
Acetylin
Acetylsal
Acetylsalicylate
Acetylsalicylic acid
Acetylsalicylsaeure
Acetylsalicylsaure
Acetylsalycilic acid
Acetyonyl
Acetysal
Acetysalicylic acid
Acide 2-(acetyloxy)benzoique
Acide acetylsalicylique
Acide acétylsalicylique
Acido O-acetil-benzoico
Acido acetilsalicilico
Acidum acetylsalicylicum
Acimetten
Acisal
Acylpyrin
Adiro
Aloxiprimum
Asacard
Asagran
Asatard
Ascoden-30
Aspalon
Aspec
Aspergum
Aspir-Mox
Aspirdrops
Aspirin
Aspirin (JP15/USP)
Aspirin [BAN:JAN]
Aspirina 03
Aspirine
Asprin
Aspro
Aspro Clear
Asteric
Azetylsalizylsaeure
Azetylsalizylsäure
BIDD:GT0118
BRN 0779271
Bay-e-4465
Bayer
Bayer Aspirin 8 Hour
Bayer Buffered
Bayer Extra Strength Aspirin For Migraine Pain
Bayer Plus
Benaspir
Bi-prin
Bialpirina
Bialpirinia
Bufferin
C01405
CCRIS 3243
CHEBI:15365
CHEMBL25
CID2244
Caprin
Cardioaspirin
Cardioaspirina
Cemirit
Claradin
Clariprin
Colfarit
Contrheuma retard
Coricidin
Crystar
D00109
D001241
DB00945
Decaten
Delgesic
Dispril
DivK1c_000555
Dolean pH 8
Duramax
ECM
EINECS 200-064-1
EU-0100038
Easprin
Easprin (TN)
Ecolen
Ecotrin
Empirin
Empirin with Codeine
Endosprin
Endydol
 
Entericin
Enterophen
Enterosarein
Enterosarine
Entrophen
Extren
Globentyl
Globoid
HMS1920E13
HMS2090G03
HMS2091K13
HMS501L17
HSDB 652
Helicon
I14-7505
IDI1_000555
Idragin
Istopirin
KBio1_000555
KBio2_001725
KBio2_002271
KBio2_004293
KBio2_004839
KBio2_006861
KBio2_007407
KBio3_002149
KBio3_002751
KBioGR_000398
KBioGR_002271
KBioSS_001725
KBioSS_002272
Kapsazal
Kyselina 2-acetoxybenzoova
Kyselina acetylsalicylova
LS-143
Levius
Lopac-A-5376
Lopac0_000038
MLS001055329
MLS001066332
MLS001336045
MLS001336046
Magnecyl
Measurin
Medisyl
Micristin
MolPort-000-871-622
NCGC00015067-01
NCGC00015067-04
NCGC00015067-09
NCGC00090977-01
NCGC00090977-02
NCGC00090977-03
NCGC00090977-04
NCGC00090977-05
NCGC00090977-06
NCGC00090977-07
NCI60_002222
NINDS_000555
NSC 27223
NSC27223
NSC406186
Neuronika
Novid
Nu-seals
Nu-seals aspirin
O-(Acetyloxy)benzoate
O-(Acetyloxy)benzoic acid
O-Acetoxybenzoate
O-Acetoxybenzoic acid
O-Acetylsalicylic acid
O-Carboxyphenyl acetate
O-accetylsalicylic acid
O-acetylsalicylic acid
PL-2200
Persistin
Pharmacin
Pirseal
Polopirin
Polopiryna
Premaspin
R16CO5Y76E [UNII]
Rheumin tabletten
Rheumintabletten
Rhodine
Rhonal
Ronal
S-211
SMR000059138
SP 189
SPBio_001838
SPECTRUM1500130
ST075414
Salacetin
Salcetogen
Saletin
Salicylic acid acetate
Salicylic acid, acetate
Salospir
Solfrin
Solprin
Solprin acid
Solpyron
Solupsan
Spectrum2_001899
Spectrum3_001295
Spectrum4_000099
Spectrum5_000740
Spectrum_001245
Spira-Dine
St. Joseph
St. Joseph Aspirin for Adults
Supac
Tasprin
Temperal
Toldex
Triaminicin
Triple-sal
UNII R16CO5Y76E
UNII-R16CO5Y76E
UNII=R16CO5Y76E
UNM-0000306102
Vanquish
WLN: QVR BOV1
XAXA
Xaxa
Yasta
ZORprin
aspirin
cMAP_000006
component of Midol
component of Synirin
nchem.859-comp6
o-Acetoxybenzoic acid
o-Carboxyphenyl acetate
o-acetoxybenzoic acid
o-carboxyphenyl acetate
ácido acetilsalicílico
2
Omalizumabapproved, investigationalPhase 4143242138-07-4
Synonyms:
242138-07-4
D05251
Ig gamma-1 chain C region
Omalizumab
 
Omalizumab (USAN/INN)
Omalizumab (genetical recombination)
Omalizumab (genetical recombination) (JAN)
Xolair
Xolair (TN)
3Cyclooxygenase InhibitorsPhase 4, Phase 3, Phase 22778
4Fibrinolytic AgentsPhase 4, Phase 3, Phase 22317
5Platelet Aggregation InhibitorsPhase 4, Phase 3, Phase 22419
6AnalgesicsPhase 4, Phase 3, Phase 211287
7Peripheral Nervous System AgentsPhase 4, Phase 3, Phase 222776
8Antirheumatic AgentsPhase 4, Phase 3, Phase 210627
9Anti-Inflammatory AgentsPhase 4, Phase 3, Phase 210355
10Analgesics, Non-NarcoticPhase 4, Phase 3, Phase 26260
11Anti-Inflammatory Agents, Non-SteroidalPhase 4, Phase 3, Phase 24295
12AntipyreticsPhase 4, Phase 3, Phase 21534
13Respiratory System AgentsPhase 44818
14Anti-Asthmatic AgentsPhase 43369
15Anti-Allergic AgentsPhase 41490
16ifetrobanPhase 24
17Tetrahydrozoline593
18Ophthalmic Solutions1092
19Prasugrel hydrochloride142389574-19-0
20Omega 3 Fatty AcidNutraceutical969

Interventional clinical trials:

idNameStatusNCT IDPhase
1The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory DiseasesCompletedNCT01867281Phase 4
2Therapeutic Utility of Xolair in Patients Undergoing Aspirin DesensitizationCompletedNCT00555971Phase 4
3Aspirin for Uncontrolled AsthmaNot yet recruitingNCT02906761Phase 3
4Trial to Determine the Safety of Oral Ifetroban in Patients With a History of Aspirin Exacerbated Respiratory DiseaseCompletedNCT02216357Phase 2
5Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD)Not yet recruitingNCT03028350Phase 2
6Challenge Test for Acetylsalicylic Acid HypersensitivityUnknown statusNCT01681615
7High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD)RecruitingNCT02064738
8Diagnosis of Aspirin Hypersensitivity in Aspirin Exacerbated Respiratory DiseaseActive, not recruitingNCT01320072
9Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin)Active, not recruitingNCT01597375
10Role of Inflammatory Mediators in AERDNot yet recruitingNCT02824523

Search NIH Clinical Center for Asthma, Aspirin-Induced


Cochrane evidence based reviews: asthma, aspirin-induced

Genetic Tests for Asthma, Aspirin-Induced

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Genetic tests related to Asthma, Aspirin-Induced:

id Genetic test Affiliating Genes
1 Asthma, Nasal Polyps, and Aspirin Intolerance27

Anatomical Context for Asthma, Aspirin-Induced

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MalaCards organs/tissues related to Asthma, Aspirin-Induced:

36
T cells, Testes

Publications for Asthma, Aspirin-Induced

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Variations for Asthma, Aspirin-Induced

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Expression for genes affiliated with Asthma, Aspirin-Induced

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Search GEO for disease gene expression data for Asthma, Aspirin-Induced.

Pathways for genes affiliated with Asthma, Aspirin-Induced

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GO Terms for genes affiliated with Asthma, Aspirin-Induced

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Sources for Asthma, Aspirin-Induced

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet