ANPAI
MCID: AST038
MIFTS: 27

Asthma, Aspirin-Induced (ANPAI) malady

Categories: Genetic diseases, Respiratory diseases

Aliases & Classifications for Asthma, Aspirin-Induced

Aliases & Descriptions for Asthma, Aspirin-Induced:

Name: Asthma, Aspirin-Induced 54 42
Asthma and Nasal Polyps 54 66 13
Asthma, with Nasal Polyps and Aspirin Intolerance 66 29
Asthma, Nasal Polyps, and Aspirin Intolerance 69
Nasal Polyps Asthma and Aspirin Sensitivity 66
Aspirin-Intolerant Asthma 66
Asthma Aspirin-Induced 66
Samter Triad 66
Asa Triad 66
Anpai 66
Aia 66

Characteristics:

HPO:

32
asthma, aspirin-induced:
Inheritance autosomal recessive inheritance


Classifications:



External Ids:

OMIM 54 208550
MeSH 42 D055963
ICD10 33 J45.9

Summaries for Asthma, Aspirin-Induced

UniProtKB/Swiss-Prot : 66 Asthma, with nasal polyps and aspirin intolerance: A condition consisting of asthma, aspirin sensitivity and nasal polyposis. Nasal polyposis is due to chronic inflammation of the paranasal sinus mucosa, leading to protrusion of edematous polyps into the nasal cavities.

MalaCards based summary : Asthma, Aspirin-Induced, also known as asthma and nasal polyps, is related to asthma and spastic paraplegia 28, autosomal recessive, and has symptoms including asthma, nasal polyposis and aspirin-induced asthma. An important gene associated with Asthma, Aspirin-Induced is PTGER2 (Prostaglandin E Receptor 2). The drugs Aspirin and Omalizumab have been mentioned in the context of this disorder. Affiliated tissues include t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and neoplasm

Wikipedia : 71 Aspirin-induced asthma, also termed Samter\'s triad, Samter\'s syndrome, aspirin-exacerbated respiratory... more...

Description from OMIM: 208550

Related Diseases for Asthma, Aspirin-Induced

Diseases related to Asthma, Aspirin-Induced via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 asthma 10.1
2 spastic paraplegia 28, autosomal recessive 9.8 PTGER2 TBX21

Symptoms & Phenotypes for Asthma, Aspirin-Induced

Symptoms by clinical synopsis from OMIM:

208550

Clinical features from OMIM:

208550

Human phenotypes related to Asthma, Aspirin-Induced:

32
id Description HPO Frequency HPO Source Accession
1 asthma 32 HP:0002099
2 nasal polyposis 32 HP:0100582
3 aspirin-induced asthma 32 HP:0012042

GenomeRNAi Phenotypes related to Asthma, Aspirin-Induced according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.36 TBX21
2 Increased shRNA abundance (Z-score > 2) GR00366-A-159 9.36 TBX21
3 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.36 PTGER2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.36 PTGER2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 TBX21
6 Increased shRNA abundance (Z-score > 2) GR00366-A-3 9.36 PTGER2
7 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 PTGER2 TBX21
8 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 TBX21
9 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.36 PTGER2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.36 TBX21

MGI Mouse Phenotypes related to Asthma, Aspirin-Induced:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.96 PTGER2 TBX21
2 respiratory system MP:0005388 8.62 PTGER2 TBX21

Drugs & Therapeutics for Asthma, Aspirin-Induced

Drugs for Asthma, Aspirin-Induced (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 20)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-78-2 2244
2
Omalizumab Approved, Investigational Phase 4 242138-07-4
3 Analgesics Phase 4,Phase 3,Phase 2
4 Analgesics, Non-Narcotic Phase 4,Phase 3,Phase 2
5 Anti-Inflammatory Agents Phase 4,Phase 3,Phase 2
6 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 3,Phase 2
7 Antipyretics Phase 4,Phase 3,Phase 2
8 Antirheumatic Agents Phase 4,Phase 3,Phase 2
9 Cyclooxygenase Inhibitors Phase 4,Phase 3,Phase 2
10 Fibrinolytic Agents Phase 4,Phase 3,Phase 2
11 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2
12 Platelet Aggregation Inhibitors Phase 4,Phase 3,Phase 2
13 Anti-Allergic Agents Phase 4
14 Anti-Asthmatic Agents Phase 4
15 Respiratory System Agents Phase 4
16 ifetroban Phase 2
17 Ophthalmic Solutions
18 Tetrahydrozoline
19 Prasugrel hydrochloride 389574-19-0
20 Omega 3 Fatty Acid Nutraceutical

Interventional clinical trials:


id Name Status NCT ID Phase
1 The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases Completed NCT01867281 Phase 4
2 Therapeutic Utility of Xolair in Patients Undergoing Aspirin Desensitization Completed NCT00555971 Phase 4
3 Aspirin for Uncontrolled Asthma Not yet recruiting NCT02906761 Phase 3
4 Trial to Determine the Safety of Oral Ifetroban in Patients With a History of Aspirin Exacerbated Respiratory Disease Completed NCT02216357 Phase 2
5 Oral Ifetroban to Treat Aspirin Exacerbated Respiratory Disease (AERD) Not yet recruiting NCT03028350 Phase 2
6 Challenge Test for Acetylsalicylic Acid Hypersensitivity Unknown status NCT01681615
7 High Omega-3/Low Omega-6 Treatment Diet for Aspirin-exacerbated Respiratory Disease (AERD) Recruiting NCT02064738
8 Diagnosis of Aspirin Hypersensitivity in Aspirin Exacerbated Respiratory Disease Active, not recruiting NCT01320072
9 Therapeutic Control of Aspirin-Exacerbated Respiratory Disease (Aspirin) Active, not recruiting NCT01597375
10 Role of Inflammatory Mediators in AERD Not yet recruiting NCT02824523

Search NIH Clinical Center for Asthma, Aspirin-Induced

Cochrane evidence based reviews: asthma, aspirin-induced

Genetic Tests for Asthma, Aspirin-Induced

Genetic tests related to Asthma, Aspirin-Induced:

id Genetic test Affiliating Genes
1 Asthma, Nasal Polyps, and Aspirin Intolerance 29

Anatomical Context for Asthma, Aspirin-Induced

MalaCards organs/tissues related to Asthma, Aspirin-Induced:

39
T Cells

Publications for Asthma, Aspirin-Induced

Variations for Asthma, Aspirin-Induced

ClinVar genetic disease variations for Asthma, Aspirin-Induced:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 TBX21 TBX21, -1993T-C single nucleotide variant Pathogenic,risk factor

Expression for Asthma, Aspirin-Induced

Search GEO for disease gene expression data for Asthma, Aspirin-Induced.

Pathways for Asthma, Aspirin-Induced

GO Terms for Asthma, Aspirin-Induced

Sources for Asthma, Aspirin-Induced

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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