Aliases & Classifications for Astigmatism

Summaries for Astigmatism

Disease Ontology : 12 A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has symptom blurred vision.

MalaCards based summary : Astigmatism is related to irregular astigmatism and regular astigmatism, and has symptoms including blurred vision and aniseikonia. An important gene associated with Astigmatism is VAX2 (Ventral Anterior Homeobox 2). The drugs Dipivefrin and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial.

Wikipedia : 71 Astigmatism is a type of refractive error in which the eye does not focus light evenly on the retina.... more...

Related Diseases for Astigmatism

Diseases related to Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
id Related Disease Score Top Affiliating Genes
1 irregular astigmatism 12.1
2 regular astigmatism 12.0
3 refractive error 11.2
4 keratoconus 11.1
5 amblyopia 11.0
6 lymphedema-distichiasis syndrome 10.8
7 ectopia lentis et pupillae 10.8
8 nystagmus 6, congenital, x-linked 10.8
9 aland island eye disease 10.8
10 megalocornea 1, x-linked 10.8
11 nystagmus 1, congenital, x-linked 10.8
12 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 10.8
13 isolated ectopia lentis 10.8
14 lacrimal duct defect 10.6
15 keratoconus 1 10.6
16 nystagmus 7, congenital, autosomal dominant 10.6
17 nystagmus 5, congenital, x-linked 10.6
18 keratoconus 5 10.6
19 macrocephaly/megalencephaly syndrome, autosomal recessive 10.6
20 nystagmus 2, congenital, autosomal dominant 10.6
21 meesmann corneal dystrophy 10.6
22 nystagmus 3, congenital, autosomal dominant 10.6
23 isolated congenital megalocornea 10.6
24 nystagmus 4, congenital, autosomal dominant 10.6
25 keratoconus 8 10.6
26 retinitis pigmentosa 10.6
27 cataract 10.5
28 myopia 10.5
29 femoral vein thrombophlebitis 10.1 ADAMTSL4 GREM1
30 anisometropia 10.1
31 presbyopia 10.0
32 endotheliitis 10.0
33 epiblepharon 9.9
34 corneal ectasia 9.8
35 pellucid marginal degeneration 9.8
36 eye disease 9.8
37 corneal degeneration 9.8
38 hemangioma 9.8
39 retinitis 9.8
40 iridocyclitis 9.7
41 congenital nystagmus 9.7
42 bullous keratopathy 9.7
43 capillary hemangioma 9.7
44 keratopathy 9.7
45 necrotizing ulcerative gingivitis 9.7 LOXL3 RPS29
46 splenic sequestration 9.5 CER1 DPT FLNA LCK SOST
47 aniseikonia 9.5
48 synostosis 9.5
49 strabismus 9.5
50 neurofibromatosis, type 1 9.5

Graphical network of the top 20 diseases related to Astigmatism:



Diseases related to Astigmatism

Symptoms & Phenotypes for Astigmatism

Symptoms:

12
  • blurred vision

UMLS symptoms related to Astigmatism:


aniseikonia

Drugs & Therapeutics for Astigmatism

Drugs for Astigmatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 104)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
3
Menthol Approved Phase 4,Phase 3 2216-51-5 16666
4
Bevacizumab Approved, Investigational Phase 4 216974-75-3
5
Fluorouracil Approved Phase 4 51-21-8 3385
6 Anesthetics Phase 4,Phase 2,Phase 3
7 Proxymetacaine Phase 4,Phase 3
8 Neurotransmitter Agents Phase 4
9 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
10 Adrenergic Agents Phase 4
11 Adrenergic Agonists Phase 4
12 Angiogenesis Inhibitors Phase 4
13 Angiogenesis Modulating Agents Phase 4
14 Antimetabolites Phase 4
15 Antimetabolites, Antineoplastic Phase 4
16 Immunosuppressive Agents Phase 4
17
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
18
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Phase 1 59-30-3 6037
20
Riboflavin Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Phase 1 83-88-5 493570
21 tannic acid Approved, Nutraceutical Phase 3
22
Flavin Mononucleotide Experimental Phase 2, Phase 3 146-17-8 643976
23 Anesthetics, Local Phase 2, Phase 3
24 Anti-Arrhythmia Agents Phase 2, Phase 3
25 Central Nervous System Depressants Phase 2, Phase 3
26 Dermatologic Agents Phase 2, Phase 3, Phase 1
27 Dextrans Phase 2, Phase 3, Phase 1
28 Diuretics, Potassium Sparing Phase 2, Phase 3
29 Micronutrients Phase 2, Phase 3, Phase 1
30 Peripheral Nervous System Agents Phase 2, Phase 3
31 Photosensitizing Agents Phase 2, Phase 3, Phase 1
32 Sodium Channel Blockers Phase 2, Phase 3
33 Trace Elements Phase 2, Phase 3, Phase 1
34 Vitamin B Complex Phase 2, Phase 3, Phase 1
35 Vitamins Phase 2, Phase 3, Phase 1
36 Mitomycins Phase 3,Phase 1
37 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
38 Polymethyl Methacrylate Phase 3
39 Protective Agents Phase 3
40 Vasodilator Agents Phase 3
41 Anticoagulants Phase 3,Phase 1,Phase 2
42 Blood Substitutes Phase 3,Phase 1,Phase 2
43 Plasma Substitutes Phase 3,Phase 1,Phase 2
44 Folate Nutraceutical Phase 2, Phase 3, Phase 1
45 Vitamin B2 Nutraceutical Phase 2, Phase 3, Phase 1
46 Vitamin B9 Nutraceutical Phase 2, Phase 3, Phase 1
47 Mydriatics Phase 2,Phase 1,Early Phase 1
48 Anti-Bacterial Agents Phase 2,Phase 1
49 Anti-Infective Agents Phase 2
50 Alkylating Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 272)
id Name Status NCT ID Phase
1 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
2 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
3 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
4 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
5 Multi Laser Platform Comparison Study for LASIK Unknown status NCT00770094 Phase 4
6 Use of Toric Intraocular Lens to Neutralize Keratometric Astigmatism Completed NCT00925886 Phase 4
7 Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism Completed NCT01763151 Phase 4
8 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
9 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
10 Prospective Evaluation of the Effectiveness of the Femtosecond Laser-assisted Refractive Astigmatic Keratotomy. Completed NCT01885780 Phase 4
11 Safety and Effectiveness of the Akreos Toric Intraocular Lens. Completed NCT00825513 Phase 4
12 Clinical Performance of Habitual Hydrogel vs. Silicone Hydrogel Toric Contact Lenses Completed NCT02142361 Phase 4
13 Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK Completed NCT00821236 Phase 4
14 Randomized Comparison of the Abbott WHITESTAR Signature System With Ellips Tranversal Ultrasound vs. the Alcon Infiniti With the Ozil Torsional Handpiece in Phacoemulsification: A Contralaterally-Controlled Trial Completed NCT01279031 Phase 4
15 AcrySof Toric Clinical Results Completed NCT01214863 Phase 4
16 Low Cylinder Toric Completed NCT00732030 Phase 4
17 An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic Patients Completed NCT01173198 Phase 4
18 Visual Outcomes After Implantation of a New Multifocal Intraocular Lens Completed NCT01505816 Phase 4
19 Daily Wear Corneal Infiltrative Event Study Completed NCT00937105 Phase 4
20 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed NCT01261975 Phase 4
21 Pseudophakic Astigmatic Reduction With Verion-LenSx Arcuate Incisions Recruiting NCT02763124 Phase 4
22 High Resolution Wavefront-guided vs. Wavefront Optimized LASIK Recruiting NCT02565537 Phase 4
23 Post-Approval Study of the TECNIS® Toric Extended Cylinder Range Intraocular Lens (IOL) Recruiting NCT02649842 Phase 4
24 A Prospective, Contralateral, Eye to Eye Comparison of SMILE Surgery to LASIK Surgery Recruiting NCT03067077 Phase 4
25 LASIK Using the Alcon Allegretto Wavefront-Guided Excimer Laser vs AMO Visx Wavefront-Guided Excimer Laser Active, not recruiting NCT01454843 Phase 4
26 Wavefront-guided PRK vs Wavefront-optimized PRK Active, not recruiting NCT02091934 Phase 4
27 Wavefront-guided Photorefractive Keratectomy (PRK) Versus Wavefront-guided Lasik for Myopia Active, not recruiting NCT01140594 Phase 4
28 Strategies for Management of Recurrent Pterygium Not yet recruiting NCT02530801 Phase 4
29 Recommendations for Monitoring Clinical Experience Following Implantation of the AcrySof® Toric Withdrawn NCT00761488 Phase 4
30 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
31 Evaluation of the BunnyLens TR Intraocular Lens Unknown status NCT01659801 Phase 3
32 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
33 Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus Unknown status NCT00371202 Phase 3
34 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3
35 Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism Completed NCT00663923 Phase 3
36 The Berkeley Orthokeratology Study Completed NCT00000123 Phase 3
37 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
38 A Prospective Study of Femtosecond Laser Intracorneal Lensectomi Completed NCT01673503 Phase 3
39 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
40 Economic Evaluation of Femtosecond Laser Assisted Cataract Surgery Completed NCT01982006 Phase 3
41 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Recruiting NCT02638376 Phase 3
42 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Recruiting NCT01604135 Phase 3
43 Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia Recruiting NCT03080077 Phase 3
44 Clinical Evaluation of CATS Tonometer Prism Not yet recruiting NCT02989909 Phase 3
45 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
46 Complete Easy Rub Comparative Efficacy Study Withdrawn NCT01019564 Phase 3
47 Myoring Versus Keraring Implantation for Keratoconus Unknown status NCT01869517 Phase 2
48 Safety and Effectiveness of Arcuate Incisions Performed With the iFS Femtosecond Laser System Completed NCT01348854 Phase 2
49 Wavefront Analyzes and Visual Performance of Three Multifocal Intra-ocular Lenses Completed NCT00876707 Phase 1, Phase 2
50 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2

Search NIH Clinical Center for Astigmatism

Cochrane evidence based reviews: astigmatism

Genetic Tests for Astigmatism

Genetic tests related to Astigmatism:

id Genetic test Affiliating Genes
1 Astigmatism 29

Anatomical Context for Astigmatism

MalaCards organs/tissues related to Astigmatism:

39
Eye, Retina, Endothelial, Testes

Publications for Astigmatism

Articles related to Astigmatism:

(show top 50) (show all 739)
id Title Authors Year
1
Changes in Astigmatism, Densitometry, and Aberrations After SMILE for Low to High Myopic Astigmatism: A 12-Month Prospective Study. ( 28068441 )
2017
2
Correction of irregular and induced regular corneal astigmatism with toric IOL after posterior segment surgery: a case series. ( 28086913 )
2017
3
Off-axis astigmatism in the isolated chicken crystalline lens. ( 27923771 )
2016
4
Effectiveness of Toric Orthokeratology in the Treatment of Patients with Combined Myopia and Astigmatism. ( 27980362 )
2016
5
Changes in the axis of astigmatism and in the fundus torsion following inferior oblique muscle weakening. ( 27138808 )
2016
6
Toric intraocular lens implantation in children with developmental cataract and preexisting corneal astigmatism. ( 27573881 )
2016
7
Total Corneal Astigmatism Measurements: Agreement Between 2 Rotating Scheimpflug Cameras. ( 28002110 )
2016
8
A control-matched comparison of flap off and flap on laser-assisted subepithelial keratectomy (LASEK) for the treatment of myopia and myopic astigmatism. ( 26949353 )
2016
9
Combined Special Capsular Tension Ring and Toric IOL Implantation for Management of Astigmatism and High Axial Myopia with Cataracts. ( 28005433 )
2016
10
Convergence Insufficiency, Accommodative Insufficiency, Visual Symptoms, and Astigmatism in Tohono O'odham Students. ( 27525112 )
2016
11
Evaluation of the diagnostic ability of vector parameters characterizing the corneal astigmatism and regularity in clinical and subclinical keratoconus. ( 27931882 )
2016
12
Single-step transepithelial photorefractive keratectomy in myopia and astigmatism: 18-month follow-up. ( 27956283 )
2016
13
Comparison of Astigmatism Induced by Combined Inferior Oblique Anterior Transposition Procedure and Lateral Rectus Recession Alone. ( 27980365 )
2016
14
Assessment of refractive astigmatism and simulated therapeutic refractive surgery strategies in coma-like-aberrations-dominant corneal optics. ( 27175371 )
2016
15
Astigmatism Correction With Toric Intraocular Lenses in Descemet Membrane Endothelial Keratoplasty Triple Procedures. ( 28002107 )
2016
16
Interaction of axial and oblique astigmatism in theoretical and physical eye models. ( 27607493 )
2016
17
A novel color-LED corneal topographer to assess astigmatism in pseudophakic eyes. ( 27574391 )
2016
18
Residual astigmatism after toric intraocular lens implantation: Analysis of data from an online toric intraocular lens back-calculator. ( 27956286 )
2016
19
Keratometry versus total corneal refractive power: Analysis of measurement repeatability with 5 different devices in normalA eyes with low astigmatism. ( 27113880 )
2016
20
Trabeculectomy With Moorfields Conjunctival Closure Technique Offers Safety Without Astigmatism Induction. ( 27120136 )
2016
21
Prevalence of corneal astigmatism before cataract surgery in Indian population. ( 27567924 )
2016
22
Astigmatism-free high-brightness 1060 nm edge-emitting lasers with narrow circular beam profile. ( 28059399 )
2016
23
Analysis of cataract surgery induced astigmatism: Two polar methods comparison. ( 28040496 )
2016
24
Treatment of mixed astigmatism: early clinical outcomes withWaveLight and Technolas excimer lasers. ( 27513239 )
2016
25
Comparison of Toric Foldable Iris-Fixated Phakic Intraocular Lens Implantation and Limbal Relaxing Incisions for Moderate-to-High Myopic Astigmatism. ( 27593877 )
2016
26
Effect of fronto-orbital advancement on astigmatism in patients with anterior plagiocephaly. ( 27567360 )
2016
27
Accuracy of total corneal astigmatism measurements with a Scheimpflug imager and a color light-emitting diode corneal topographer. ( 27131773 )
2016
28
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. ( 27660920 )
2016
29
Off-axis astigmatism in the isolated chicken crystalline lens. ( 27984063 )
2016
30
Authors reply to: toric intraocular lens implantation in children with developmental cataract and preexisting corneal astigmatism by Ram etA al. ( 27966837 )
2016
31
Aspheric Micro-monovision LASIK in Correction of Presbyopia and Myopic Astigmatism: Early Clinical Outcomes in a Chinese Population. ( 27722755 )
2016
32
Development of a nomogram for femtosecond laser astigmatic keratotomy for astigmatism after keratoplasty. ( 27113878 )
2016
33
Astigmatism terminology and source references. ( 27113891 )
2016
34
Correlation of higher order aberrations and components of astigmatism in myopic refractive surgery candidates. ( 27579454 )
2016
35
Ocular residual astigmatism (ORA) in pre-cataract eyes prior to and after refractive lens exchange. ( 27624172 )
2016
36
Long-term follow-up of astigmatic keratotomy for corneal astigmatism after penetrating keratoplasty. ( 27150121 )
2016
37
Surgically induced astigmatism is characterized by optical vectors, not by ratios. ( 27026473 )
2016
38
The Influence of Induced Astigmatism on the Depth of Focus. ( 27536975 )
2016
39
Combination of Toric and multifocal intraocular lens implantation in bilateral cataract patients with unilateral astigmatism. ( 28003977 )
2016
40
Development of a program for toric intraocular lens calculation considering posterior corneal astigmatism, incision-induced posterior corneal astigmatism, and effective lens position. ( 27541160 )
2016
41
Threshold limit of postoperative astigmatism for patient satisfaction after refractive lens exchange and multifocal intraocular lens implantation. ( 27531287 )
2016
42
Distribution of the Anterior and Posterior Corneal Astigmatism in Eyes with Keratoconus. ( 27066720 )
2016
43
Long-Term Comparison of Posterior Chamber Phakic Intraocular Lens With and Without a Central Hole (Hole ICL and Conventional ICL) Implantation for Moderate to High Myopia and Myopic Astigmatism: Consort-Compliant Article. ( 27057883 )
2016
44
Effect of posterior corneal astigmatism on power calculation and alignment of toric intraocular lenses: Comparison of methodologies. ( 27026445 )
2016
45
Transmissive liquid-crystal device for correcting primary coma aberration and astigmatism in biospecimen in two-photon excitation laser scanning microscopy. ( 27624000 )
2016
46
Predictors of femtosecond laser intrastromal astigmatic keratotomy efficacy for astigmatism management in cataract surgery. ( 27026450 )
2016
47
Astigmatism in underserved rural areas: a population based study. ( 27572485 )
2016
48
Excimer Laser Versus Phakic Intraocular Lenses for Myopia and Astigmatism: A Meta-Analysis of Randomized Controlled Trials. ( 27930395 )
2016
49
Long-term Visual and Refractive Outcomes After LASIK for High Myopia and Astigmatism From -8.00 to -14.25 D. ( 27163613 )
2016
50
Changes in astigmatism and corneal higher-order aberrations after phacoemulsification with toric intraocular lens implantation for mild keratoconus with cataract. ( 27165708 )
2016

Variations for Astigmatism

ClinVar genetic disease variations for Astigmatism:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 GRIN2B NM_000834.3(GRIN2B): c.2002G> A (p.Asp668Asn) single nucleotide variant Pathogenic rs876661151 GRCh38 Chromosome 12, 13608611: 13608611

Expression for Astigmatism

Search GEO for disease gene expression data for Astigmatism.

Pathways for Astigmatism

GO Terms for Astigmatism

Cellular components related to Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 ADAMTSL4 CER1 DPT GREM1 LOXL3 SOST
2 extracellular matrix GO:0031012 8.92 ADAMTSL4 DPT FLNA SOST

Biological processes related to Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 signal transduction involved in regulation of gene expression GO:0023019 9.26 CER1 PDGFRA
2 positive regulation of integrin-mediated signaling pathway GO:2001046 9.16 FLNA LOXL3
3 determination of dorsal identity GO:0048263 8.96 CER1 GREM1
4 negative regulation of BMP signaling pathway GO:0030514 8.8 CER1 GREM1 SOST

Molecular functions related to Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 BMP binding GO:0036122 8.96 CER1 GREM1
2 morphogen activity GO:0016015 8.62 CER1 GREM1

Sources for Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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