Aliases & Classifications for Astigmatism

MalaCards integrated aliases for Astigmatism:

Name: Astigmatism 12 29 52 42 14 69

Classifications:



External Ids:

Disease Ontology 12 DOID:11782
ICD10 33 H52.2 H52.20
ICD9CM 35 367.2 367.20
MeSH 42 D001251
UMLS 69 C0004106

Summaries for Astigmatism

Disease Ontology : 12 A refractive error characterized by the optics of the eye to focus a point object into a sharp focused image on the retina, has symptom blurred vision.

MalaCards based summary : Astigmatism is related to irregular astigmatism and regular astigmatism, and has symptoms including aniseikonia An important gene associated with Astigmatism is ANKRD11 (Ankyrin Repeat Domain 11). The drugs Dipivefrin and Hyaluronic acid have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotype is vision/eye.

Wikipedia : 72 Astigmatism is a type of refractive error in which the eye does not focus light evenly on the retina.... more...

Related Diseases for Astigmatism

Diseases related to Astigmatism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
id Related Disease Score Top Affiliating Genes
1 irregular astigmatism 12.0
2 regular astigmatism 12.0
3 refractive error 11.2
4 keratoconus 11.2
5 amblyopia 11.0
6 nystagmus 6, congenital, x-linked 10.8
7 aland island eye disease 10.8
8 megalocornea 1, x-linked 10.8
9 nystagmus 1, congenital, x-linked 10.8
10 microcephaly with or without chorioretinopathy, lymphedema, or mental retardation 10.8
11 isolated ectopia lentis 10.8
12 lymphedema-distichiasis syndrome 10.8
13 ectopia lentis et pupillae 10.8
14 keratoconus 5 10.6
15 nystagmus 5, congenital, x-linked 10.6
16 macrocephaly/megalencephaly syndrome, autosomal recessive 10.6
17 nystagmus 2, congenital, autosomal dominant 10.6
18 nystagmus 3, congenital, autosomal dominant 10.6
19 familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis 10.6
20 ichthyosis follicularis atrichia photophobia syndrome 10.6
21 isolated congenital megalocornea 10.6
22 meesmann corneal dystrophy 10.6
23 nystagmus 4, congenital, autosomal dominant 10.6
24 retinitis pigmentosa 10.6
25 keratoconus 8 10.6
26 lacrimal duct defect 10.6
27 nystagmus 7, congenital, autosomal dominant 10.6
28 keratoconus 1 10.6
29 aldosterone-producing adenoma 10.5 FRMD7 GPR143
30 cataract 10.5
31 chronic pulmonary heart disease 10.5 KRT12 KRT3
32 stromal dystrophy 10.5 KRT12 KRT3
33 aphthous stomatitis 10.5 FRMD7 GPR143
34 myopia 10.5
35 liver disease 10.4 KRT12 KRT3
36 oral mucosa leukoplakia 10.4 FRMD7 GPR143
37 white sponge nevus 1 10.4 KRT12 KRT3
38 enterocele 10.3 FRMD7 GPR143
39 corneal dystrophy, epithelial basement membrane 10.2 KRT12 KRT3
40 anisometropia 10.1
41 presbyopia 10.0
42 endotheliitis 10.0
43 acute allergic serous otitis media 10.0 KRT12 KRT3
44 epiblepharon 9.9
45 corneal ectasia 9.8
46 pellucid marginal degeneration 9.8
47 hemangioma 9.8
48 retinitis 9.8
49 eye disease 9.8
50 corneal degeneration 9.8

Graphical network of the top 20 diseases related to Astigmatism:



Diseases related to Astigmatism

Symptoms & Phenotypes for Astigmatism

UMLS symptoms related to Astigmatism:


aniseikonia

MGI Mouse Phenotypes related to Astigmatism:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.1 DPT GPR143 KRT12 VAX2 ANKRD11 CACNA1F

Drugs & Therapeutics for Astigmatism

Drugs for Astigmatism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 105)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dipivefrin Approved Phase 4,Phase 3 52365-63-6 3105
2
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
3
Bevacizumab Approved, Investigational Phase 4 216974-75-3
4
Fluorouracil Approved Phase 4 51-21-8 3385
5 Anesthetics Phase 4,Phase 2,Phase 3
6 Proxymetacaine Phase 4,Phase 3
7 Neurotransmitter Agents Phase 4
8 Pharmaceutical Solutions Phase 4,Phase 2,Phase 3,Phase 1
9 Adrenergic Agents Phase 4
10 Adrenergic Agonists Phase 4
11 Angiogenesis Inhibitors Phase 4
12 Angiogenesis Modulating Agents Phase 4
13 Antimetabolites Phase 4
14 Antimetabolites, Antineoplastic Phase 4
15 Immunosuppressive Agents Phase 4
16
Lidocaine Approved, Vet_approved Phase 2, Phase 3 137-58-6 3676
17
Menthol Approved Phase 3 2216-51-5 16666
18
Benzocaine Approved Phase 3 1994-09-7, 94-09-7 2337
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Phase 1 59-30-3 6037
20
Riboflavin Approved, Nutraceutical, Vet_approved Phase 2, Phase 3, Phase 1 83-88-5 493570
21 tannic acid Approved, Nutraceutical Phase 3
22
Flavin Mononucleotide Experimental Phase 2, Phase 3 146-17-8 643976
23 Anesthetics, Local Phase 2, Phase 3
24 Anti-Arrhythmia Agents Phase 2, Phase 3
25 Central Nervous System Depressants Phase 2, Phase 3
26 Dermatologic Agents Phase 2, Phase 3, Phase 1
27 Dextrans Phase 2, Phase 3, Phase 1
28 Diuretics, Potassium Sparing Phase 2, Phase 3
29 Micronutrients Phase 2, Phase 3, Phase 1
30 Peripheral Nervous System Agents Phase 2, Phase 3
31 Photosensitizing Agents Phase 2, Phase 3, Phase 1
32 Sodium Channel Blockers Phase 2, Phase 3
33 Trace Elements Phase 2, Phase 3, Phase 1
34 Vitamin B Complex Phase 2, Phase 3, Phase 1
35 Vitamins Phase 2, Phase 3, Phase 1
36 Mitomycins Phase 3,Phase 1
37 Ophthalmic Solutions Phase 3,Phase 1,Phase 2
38 Polymethyl Methacrylate Phase 3
39 Protective Agents Phase 3
40 Vasodilator Agents Phase 3
41 Anticoagulants Phase 3,Phase 1,Phase 2
42 Blood Substitutes Phase 3,Phase 1,Phase 2
43 Plasma Substitutes Phase 3,Phase 1,Phase 2
44 Folate Nutraceutical Phase 2, Phase 3, Phase 1
45 Vitamin B2 Nutraceutical Phase 2, Phase 3, Phase 1
46 Vitamin B9 Nutraceutical Phase 2, Phase 3, Phase 1
47 Mydriatics Phase 2,Phase 1,Early Phase 1
48 Anti-Bacterial Agents Phase 2,Phase 1
49 Anti-Infective Agents Phase 2
50 Alkylating Agents Phase 1

Interventional clinical trials:

(show top 50) (show all 285)

id Name Status NCT ID Phase Drugs
1 Effect of Posterior Corneal Toricity on Refractive Outcome of Pseudophakia Unknown status NCT01554761 Phase 4
2 Prospective Investigation of SUPRACOR Visual Outcomes of Presbyopic Hyperopic Patients With and Without Astigmatism Unknown status NCT01628146 Phase 4
3 Clinical Evaluation of Toric Intraocular Lens Made by Aurolab Unknown status NCT01396616 Phase 4
4 A Intra-patient Comparison of Closed Loop and Plate Haptic Toric Intraocular Lenses Unknown status NCT02264457 Phase 4
5 Multi Laser Platform Comparison Study for LASIK Unknown status NCT00770094 Phase 4
6 Use of Toric Intraocular Lens to Neutralize Keratometric Astigmatism Completed NCT00925886 Phase 4
7 Comparison of Toric IOL Implantation and Opposite Clear Corneal Incision During Cataract Surgery to Correct Corneal Astigmatism Completed NCT01763151 Phase 4
8 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
9 Clinical Performance of Biofinity Toric Versus Air Optix for Astigmatism Completed NCT01965288 Phase 4
10 Prospective Evaluation of the Effectiveness of the Femtosecond Laser-assisted Refractive Astigmatic Keratotomy. Completed NCT01885780 Phase 4
11 Safety and Effectiveness of the Akreos Toric Intraocular Lens. Completed NCT00825513 Phase 4
12 Clinical Performance of Habitual Hydrogel vs. Silicone Hydrogel Toric Contact Lenses Completed NCT02142361 Phase 4
13 Contralateral Comparison of Three Excimer Laser Systems in Performing LASIK Completed NCT00821236 Phase 4
14 Randomized Comparison of the Abbott WHITESTAR Signature System With Ellips Tranversal Ultrasound vs. the Alcon Infiniti With the Ozil Torsional Handpiece in Phacoemulsification: A Contralaterally-Controlled Trial Completed NCT01279031 Phase 4
15 AcrySof Toric Clinical Results Completed NCT01214863 Phase 4
16 Low Cylinder Toric Completed NCT00732030 Phase 4
17 An Evaluation of Outcomes Following Wavefront Optimized or Wavefront Guided Lasik Procedure in Low to Moderate Myopic Patients Completed NCT01173198 Phase 4
18 Visual Outcomes After Implantation of a New Multifocal Intraocular Lens Completed NCT01505816 Phase 4
19 Daily Wear Corneal Infiltrative Event Study Completed NCT00937105 Phase 4
20 Co-Axial Micro-Incision Versus Co-Axial Small Incision Cataract Surgery Using the Stellaris Enhancement System Completed NCT01261975 Phase 4
21 High Resolution Wavefront-guided vs. Wavefront Optimized LASIK Recruiting NCT02565537 Phase 4
22 A Prospective, Contralateral, Eye to Eye Comparison of SMILE Surgery to LASIK Surgery Recruiting NCT03067077 Phase 4
23 LASIK Using the Alcon Allegretto Wavefront-Guided Excimer Laser vs AMO Visx Wavefront-Guided Excimer Laser Active, not recruiting NCT01454843 Phase 4
24 Wavefront-guided PRK vs Wavefront-optimized PRK Active, not recruiting NCT02091934 Phase 4
25 Wavefront-guided Photorefractive Keratectomy (PRK) Versus Wavefront-guided Lasik for Myopia Active, not recruiting NCT01140594 Phase 4
26 Topography-guided LASIK Surgery Not yet recruiting NCT03292419 Phase 4
27 Strategies for Management of Recurrent Pterygium Not yet recruiting NCT02530801 Phase 4 Bevacizumab;5 fluorouracil
28 Recommendations for Monitoring Clinical Experience Following Implantation of the AcrySof® Toric Withdrawn NCT00761488 Phase 4
29 SUPRACOR for Myopia and Myopic Astigmatism Unknown status NCT01404884 Phase 3
30 Evaluation of the BunnyLens TR Intraocular Lens Unknown status NCT01659801 Phase 3
31 Intrastromal Correction of Ametropia by a Femtosecond Laser Unknown status NCT00928122 Phase 3
32 Comparison of Penetrating Keratoplasty and Deep Lamellar Keratoplasty With the Big Bubble Technique for Keratoconus Unknown status NCT00371202 Phase 3
33 Treatment of Keratoconus Using Collagen Cross-Linking Unknown status NCT00841386 Phase 2, Phase 3 Riboflavin-5-phosphate;Sham cross-linking
34 Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism Completed NCT00663923 Phase 3
35 The Berkeley Orthokeratology Study Completed NCT00000123 Phase 3
36 Multicenter Evaluation of Safety and Effectiveness of Presbyopic LASIK for Hyperopes Completed NCT00910403 Phase 3
37 A Prospective Study of Femtosecond Laser Intracorneal Lensectomi Completed NCT01673503 Phase 3
38 Effects of Prismatic Spectacle Lenses on Symptoms of Dizziness, Headache and Anxiety as Caused by Vertical Heterophoria Completed NCT00785135 Phase 3
39 Economic Evaluation of Femtosecond Laser Assisted Cataract Surgery Completed NCT01982006 Phase 3
40 Evaluating the Safety and Efficacy of the KXL System for Corneal Collagen Cross-Linking in Eyes Having Keratoconus Recruiting NCT02638376 Phase 3
41 Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial Recruiting NCT01604135 Phase 3
42 Safety and Effectiveness of Corneal Crosslinking (CXL): Keratoconus and Post-Refractive Ectasia Recruiting NCT03080077 Phase 3 Ricrolin+;Epi-Off
43 Corneal Cross Linking and Topography Guided Excimer Laser Treatment Terminated NCT01682993 Phase 3
44 Myoring Versus Keraring Implantation for Keratoconus Unknown status NCT01869517 Phase 2
45 Safety and Effectiveness of Arcuate Incisions Performed With the iFS Femtosecond Laser System Completed NCT01348854 Phase 2
46 Wavefront Analyzes and Visual Performance of Three Multifocal Intra-ocular Lenses Completed NCT00876707 Phase 1, Phase 2
47 Is Non-cycloplegic Photorefraction Applicable for Screening Refractive Risk Factors of Amblyopia? Completed NCT01308307 Phase 2
48 Comparative Evaluation of Corneal Staining With Balafilcon A Lenses and Two Multi-Purpose Solutions Completed NCT01024855 Phase 1, Phase 2
49 Eye Muscle Surgery to Treat Congenital Nystagmus Completed NCT00001866 Phase 2
50 Safety and Efficacy of Corneal Collagen Cross-linking Following LASIK for Treatment of Hyperopia and Hyperopic Astigmatism Terminated NCT01893359 Phase 1, Phase 2 riboflavin ophthalmic solution, 0% dextran

Search NIH Clinical Center for Astigmatism

Cochrane evidence based reviews: astigmatism

Genetic Tests for Astigmatism

Genetic tests related to Astigmatism:

id Genetic test Affiliating Genes
1 Astigmatism 29

Anatomical Context for Astigmatism

MalaCards organs/tissues related to Astigmatism:

39
Eye, Retina, Endothelial, Testes

Publications for Astigmatism

Articles related to Astigmatism:

(show top 50) (show all 761)
id Title Authors Year
1
Neck/shoulder discomfort due to visually demanding experimental near work is influenced by previous neck pain, task duration, astigmatism, internal eye discomfort and accommodation. ( 28832612 )
2017
2
Intrastromal Corneal Ring Segments for Astigmatism Correction after Deep Anterior Lamellar Keratoplasty. ( 28951784 )
2017
3
Changes in Astigmatism, Densitometry, and Aberrations After SMILE for Low to High Myopic Astigmatism: A 12-Month Prospective Study. ( 28068441 )
2017
4
Refractive Outcomes of 20 Eyes Undergoing ICL Implantation for Correction of Hyperopic Astigmatism. ( 28880335 )
2017
5
Consistency analysis of surgically induced astigmatism. ( 28917416 )
2017
6
Comparison of refractive and keratometric astigmatism after microincision cataractA surgery. ( 28917405 )
2017
7
Anisometropia of spherical equivalent and astigmatism among myopes: a 23-year follow-up study of prevalence and changes from childhood to adulthood. ( 28481050 )
2017
8
Association between mode of delivery and astigmatism in preschool children. ( 28887859 )
2017
9
Comparison between toric and spherical phakic intraocular lenses combined with astigmatic keratotomy for high myopic astigmatism. ( 28828390 )
2017
10
Polar Value Analysis of Low to Moderate Astigmatism with Wavefront-Guided Sub-Bowman Keratomileusis. ( 28831306 )
2017
11
Correction of irregular and induced regular corneal astigmatism with toric IOL after posterior segment surgery: a case series. ( 28086913 )
2017
12
Refractive Outcomes of Posterior Chamber Phakic Intraocular Lens Implantation for Correction of Myopia and Myopic Astigmatism. ( 28790537 )
2017
13
Stepwise Guided Photorefractive Keratectomy in Treatment of Irregular Astigmatism After Penetrating Keratoplasty and Deep Anterior Lamellar Keratoplasty. ( 28914632 )
2017
14
Validity of autorefractor based screening method for irregular astigmatism compared to the corneal topography- a cross sectional study. ( 28944202 )
2017
15
Effect of iris registration on outcomes of FEMTOLASIK for myopia and myopic astigmatism. ( 28875250 )
2017
16
Photorefractive keratectomy in the management of postradial keratotomy hyperopia and astigmatism. ( 28919909 )
2017
17
Correction of hyperopia with astigmatism following radial keratotomy with daily disposable plus spherical contact lens: a case report. ( 28856508 )
2017
18
Comparison of astigmatism prediction error taken with the Pentacam measurements, Baylor nomogram, and Barrett formula for toric intraocular lens implantation. ( 28836956 )
2017
19
Implantation of a Multifocal Toric Intraocular Lens after Radial Keratotomy and Cross-Linking with Hyperopia and Astigmatism Residues: A Case Report. ( 28924444 )
2017
20
Axis-free correction of astigmatism using bifocal soft contact lenses. ( 28935527 )
2017
21
Refractive, corneal and ocular residual astigmatism: distribution in a German population and age-dependency - the Gutenberg health study. ( 28823075 )
2017
22
Correction of High Astigmatism after Penetrating Keratoplasty with Toric Multifocal Intraocular Lens Implantation. ( 28868034 )
2017
23
Note: Measurement of synchrotron radiation phase-space beam properties to verify astigmatism compensation in Fresnel zone plate focusing optics. ( 28863654 )
2017
24
Astigmatism in underserved rural areas: a population based study. ( 27572485 )
2016
25
Long-Term Comparison of Posterior Chamber Phakic Intraocular Lens With and Without a Central Hole (Hole ICL and Conventional ICL) Implantation for Moderate to High Myopia and Myopic Astigmatism: Consort-Compliant Article. ( 27057883 )
2016
26
Off-axis astigmatism in the isolated chicken crystalline lens. ( 27923771 )
2016
27
Effectiveness of Toric Orthokeratology in the Treatment of Patients with Combined Myopia and Astigmatism. ( 27980362 )
2016
28
Toric intraocular lens implantation in children with developmental cataract and preexisting corneal astigmatism. ( 27573881 )
2016
29
Residual astigmatism after toric intraocular lens implantation: Analysis of data from an online toric intraocular lens back-calculator. ( 27956286 )
2016
30
Transmissive liquid-crystal device for correcting primary coma aberration and astigmatism in biospecimen in two-photon excitation laser scanning microscopy. ( 27624000 )
2016
31
Analysis of components of total astigmatism in infants and young children. ( 27138592 )
2016
32
Predictors of femtosecond laser intrastromal astigmatic keratotomy efficacy for astigmatism management in cataract surgery. ( 27026450 )
2016
33
A novel color-LED corneal topographer to assess astigmatism in pseudophakic eyes. ( 27574391 )
2016
34
Astigmatism terminology and source references. ( 27113891 )
2016
35
Development of a nomogram for femtosecond laser astigmatic keratotomy for astigmatism after keratoplasty. ( 27113878 )
2016
36
Clinical Performance of a Spherical Hybrid Lens Design in High Regular Astigmatism. ( 27660920 )
2016
37
Combined Special Capsular Tension Ring and Toric IOL Implantation for Management of Astigmatism and High Axial Myopia with Cataracts. ( 28005433 )
2016
38
Total Corneal Astigmatism Measurements: Agreement Between 2 Rotating Scheimpflug Cameras. ( 28002110 )
2016
39
Refractive and Quality of Vision Outcomes with Toric IOL Implantation in Low Astigmatism. ( 28070415 )
2016
40
Does astigmatism alter with cycloplegia? ( 27579457 )
2016
41
Prevalence of corneal astigmatism before cataract surgery in Indian population. ( 27567924 )
2016
42
Corneal Astigmatism Stability in Descemet Membrane Endothelial Keratoplasty for Fuchs Corneal Dystrophy. ( 27191667 )
2016
43
Threshold limit of postoperative astigmatism for patient satisfaction after refractive lens exchange and multifocal intraocular lens implantation. ( 27531287 )
2016
44
Astigmatism Correction With Toric Intraocular Lenses in Descemet Membrane Endothelial Keratoplasty Triple Procedures. ( 28002107 )
2016
45
Internal Astigmatism in Myopes and Non-myopes: Compensation or Constant? ( 27564515 )
2016
46
Mode-coupling enhancement by pump astigmatism correction in a Ti:Sapphire femtosecond laser. ( 27958484 )
2016
47
Keratometry versus total corneal refractive power: Analysis of measurement repeatability with 5 different devices in normalA eyes with low astigmatism. ( 27113880 )
2016
48
Long-term follow-up of astigmatic keratotomy for corneal astigmatism after penetrating keratoplasty. ( 27150121 )
2016
49
Comparison of Toric Foldable Iris-Fixated Phakic Intraocular Lens Implantation and Limbal Relaxing Incisions for Moderate-to-High Myopic Astigmatism. ( 27593877 )
2016
50
Changes in the axis of astigmatism and in the fundus torsion following inferior oblique muscle weakening. ( 27138808 )
2016

Variations for Astigmatism

ClinVar genetic disease variations for Astigmatism:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 ANKRD11 NM_013275.5(ANKRD11): c.5317G> T (p.Glu1773Ter) single nucleotide variant Pathogenic rs1114167291 GRCh37 Chromosome 16, 89347633: 89347633
2 GRIN2B NM_000834.4(GRIN2B): c.2002G> A (p.Asp668Asn) single nucleotide variant Pathogenic/Likely pathogenic rs876661151 GRCh38 Chromosome 12, 13608611: 13608611

Expression for Astigmatism

Search GEO for disease gene expression data for Astigmatism.

Pathways for Astigmatism

GO Terms for Astigmatism

Biological processes related to Astigmatism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 collagen fibril organization GO:0030199 9.16 DPT GREM1
2 face morphogenesis GO:0060325 8.96 ANKRD11 PDGFRA
3 visual perception GO:0007601 8.92 CACNA1F GPR143 KRT12 VAX2

Sources for Astigmatism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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