MCID: AST002
MIFTS: 44

Astroblastoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Astroblastoma

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Sources:
43NIH Rare Diseases, 65Wikipedia, 33MalaCards
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NIH Rare Diseases:43 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards: Astroblastoma, also known as cerebral astroblastoma, is related to ependymoma and astrocytoma. An important gene associated with Astroblastoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoplasmic microtubules. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and hypothalamus, and related mouse phenotypes are vision/eye and cellular.

Wikipedia:65 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Aliases & Classifications for Astroblastoma

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8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 62UMLS, 40NCIt, 35MeSH, 58SNOMED-CT, 63UMLS via Orphanet, 59SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

49
astroblastoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

astroblastoma 8 43 10 45 49 62
cerebral astroblastoma 43


External Ids:

Disease Ontology8 DOID:7305
NCIt40 C4324
MeSH35 D018302
SNOMED-CT58 48952003
UMLS via Orphanet63 C0334587
SNOMED-CT via Orphanet59 48952003

Related Diseases for Astroblastoma

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Symptoms for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Astroblastoma

Search NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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33MalaCards
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MalaCards organs/tissues related to Astroblastoma:

33
Brain, Cerebellum, Hypothalamus, Temporal lobe, Parietal lobe, Spinal cord, Bone

Animal Models for Astroblastoma or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Astroblastoma:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5VIM, DSC1, GFAP
2MP:00053848.5VIM, DSC1, GFAP
3MP:00053868.4VIM, DSC1, GFAP
4MP:00053878.2GFAP, DSC1, VIM

Publications for Astroblastoma

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52PubMed
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Articles related to Astroblastoma:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
2
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. (23301912)
2013
3
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
4
Cerebral astroblastoma: A case report and review of literature. (22870162)
2012
5
Clinical features and post-surgical outcome of patients with astroblastoma. (21507653)
2011
6
Anaplastic astroblastoma: a rare glial tumour. (22679316)
2011
7
Astroblastoma with bone invasion. (22347336)
2011
8
A newborn with massive congenital astroblastoma. (21491993)
2011
9
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
10
Two cases of pediatric high-grade astroblastoma with different clinical behavior. (20437876)
2010
11
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
12
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
13
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
14
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. (19214707)
2009
15
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
16
Astroblastoma in a child. (17653728)
2008
17
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. (19096646)
2008
18
Intraventricular astroblastoma. Case report. (18352788)
2008
19
Brainstem astroblastoma: a case report and review of the literature. (17765957)
2008
20
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. (18280055)
2008
21
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
22
Neuroradiologic characteristics of astroblastoma. (17216265)
2007
23
Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. (17369788)
2007
24
'Low-grade' astroblastoma with rapid recurrence: a case report. (16484017)
2006
25
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. (16636749)
2006
26
Low-grade astroblastoma recurring with extensive invasion. (16998280)
2006
27
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
28
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
29
Identification of phenotypic neural stem cells in a pediatric astroblastoma. (16302618)
2005
30
Cerebral astroblastoma. (15168232)
2004
31
Astroblastoma: diffusion MRI, and proton MR spectroscopy. (11918982)
2002
32
Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. (11847049)
2002
33
Astroblastoma with unusual signet-ring-like cell components: a case report and literature review. (12416560)
2002
34
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
35
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
36
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
37
Astroblastoma: does histology predict biologic behavior? (9874187)
1998
38
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
39
Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. (8352168)
1993
40
Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. (8516227)
1993
41
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
42
The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. (2683559)
1989
43
Astroblastoma revisited: a report of three cases. (3727930)
1986
44
The fine structure of astroblastoma. (3967170)
1985
45
The angioarchitecture of the astroblastoma. (1222508)
1975
46
Clinical pathological conference; astroblastoma. (14899596)
1952
47
A study of 182 patients with verified astrocytoma, astroblastoma and oligodendroglioma of the brain. (15422396)
1950
48
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
49
Astroblastoma of the brain with sudden death. (15406883)
1949
50
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949

Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for genes affiliated with Astroblastoma

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50PathCards, 38NCBI BioSystems Database, 12EMD Millipore, 60Thomson Reuters
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Pathways related to Astroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0VIM, GFAP
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.0VIM, GFAP

Compounds for genes affiliated with Astroblastoma

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45Novoseek, 11DrugBank, 24HMDB, 51PharmGKB, 29IUPHAR, 61Tocris Bioscience, 3BitterDB
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Compounds related to Astroblastoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1eosin459.4VIM, GFAP
2s 100459.4VIM, GFAP
3reticulin459.4VIM, GFAP
4retinaldehyde459.4VIM, GFAP
5silicone459.4GFAP, VIM
6streptozotocin459.4VIM, GFAP
7hematoxylin459.4VIM, GFAP
8ganciclovir45 1110.4GFAP, VIM
9neomycin459.4VIM, GFAP
10ganglioside459.4GFAP, VIM
11dbc-amp459.4VIM, GFAP
12chondroitin sulfate45 2410.4VIM, GFAP
13cytarabine45 51 1111.4GFAP, VIM
14cocaine45 1110.4VIM, GFAP
15bromodeoxyuridine459.4VIM, GFAP
165-hydroxytryptamine459.4VIM, GFAP
17choline45 24 1111.4GFAP, VIM
18formaldehyde45 2410.4VIM, GFAP
19isoproterenol45 1110.3VIM, GFAP
20agar459.3GFAP, VIM
21gaba459.3VIM, GFAP
22matrigel459.3GFAP, VIM
23butyrate459.3VIM, GFAP
24methionine459.3VIM, GFAP
25nmda45 2910.3VIM, GFAP
26paclitaxel45 51 1111.3GFAP, VIM
27acetylcholine45 51 29 24 1113.2VIM, GFAP
28glycogen45 2410.2VIM, GFAP
29estradiol45 24 1111.2GFAP, VIM
30paraffin459.1VIM, GFAP
31forskolin45 51 1111.1GFAP, VIM
32genistein45 29 61 3 24 1114.0VIM, GFAP
33lactate459.0VIM, GFAP
34glutamine458.9VIM, GFAP
35retinoic acid45 249.9VIM, DSC1, GFAP
36iron45 249.7VIM, GFAP

GO Terms for genes affiliated with Astroblastoma

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16Gene Ontology
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Cellular components related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0VIM, GFAP

Biological processes related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.0VIM, GFAP
2negative regulation of neuron projection developmentGO:0109779.0VIM, GFAP
3astrocyte developmentGO:0140028.9VIM, GFAP
4intermediate filament organizationGO:0451098.7VIM, GFAP

Molecular functions related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0VIM, GFAP

Products for genes affiliated with Astroblastoma

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Sources for Astroblastoma

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet