MCID: AST002
MIFTS: 40

Astroblastoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Astroblastoma

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards: Astroblastoma, also known as cerebral astroblastoma, is related to oligodendroglioma and cerebritis. An important gene associated with Astroblastoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoskeleton remodeling Neurofilaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and parietal lobe, and related mouse phenotype vision/eye.

Wikipedia:63 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Aliases & Classifications for Astroblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
astroblastoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

astroblastoma 8 42 10 44 48 60
cerebral astroblastoma 42


External Ids:

Disease Ontology8 DOID:7305
NCIt39 C4324
SNOMED-CT56 48952003
MeSH34 D018302
SNOMED-CT via Orphanet57 48952003

Related Diseases for Astroblastoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Clinical Features for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Astroblastoma

Drug clinical trials:

Search ClinicalTrials for Astroblastoma

Search NIH Clinical Center for Astroblastoma

Search CenterWatch for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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32MalaCards
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MalaCards organs/tissues related to Astroblastoma:

32
Brain, Cerebellum, Parietal lobe, Temporal lobe, Hypothalamus, Bone, Spinal cord

Animal Models for Astroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Astroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5GFAP, DSC1, VIM

Publications for Astroblastoma

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50PubMed
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Articles related to Astroblastoma:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
2
Cerebral astroblastoma in an adult: an immunohistochemical, ultrastructural and genetic study. (22994361)
2013
3
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
4
Cerebral astroblastoma: A case report and review of literature. (22870162)
2012
5
Clinical features and post-surgical outcome of patients with astroblastoma. (21507653)
2011
6
Anaplastic astroblastoma: a rare glial tumour. (22679316)
2011
7
A newborn with massive congenital astroblastoma. (21491993)
2011
8
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
9
Two cases of pediatric high-grade astroblastoma with different clinical behavior. (20437876)
2010
10
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
11
Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1. (20860891)
2010
12
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
13
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
14
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. (19214707)
2009
15
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
16
Astroblastoma in a child. (17653728)
2008
17
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. (19096646)
2008
18
Intraventricular astroblastoma. Case report. (18352788)
2008
19
Brainstem astroblastoma: a case report and review of the literature. (17765957)
2008
20
Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. (18415663)
2008
21
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
22
Neuroradiologic characteristics of astroblastoma. (17216265)
2007
23
Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. (17369788)
2007
24
An astroblastoma mimicking a cavernous malformation: case report. (17327764)
2007
25
Astroblastoma presenting with intracerebral hemorrhage misdiagnosed as dural arteriovenous fistula: review of a rare entity. (17320647)
2007
26
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. (16636749)
2006
27
Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation. (16521483)
2006
28
Complete surgical resection of high-grade astroblastoma with long time survival: case report and review of the literature. (16565782)
2006
29
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
30
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
31
Identification of phenotypic neural stem cells in a pediatric astroblastoma. (16302618)
2005
32
Astroblastoma: a case report. (15483362)
2004
33
Astroblastoma: diffusion MRI, and proton MR spectroscopy. (11918982)
2002
34
Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. (11847049)
2002
35
Astroblastoma with unusual signet-ring-like cell components: a case report and literature review. (12416560)
2002
36
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
37
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
38
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
39
Astroblastoma: does histology predict biologic behavior? (9874187)
1998
40
Cerebral astroblastoma resembling an extra-axial neoplasm. (8767917)
1996
41
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
42
Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. (8352168)
1993
43
Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. (8516227)
1993
44
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
45
The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. (2683559)
1989
46
Astroblastoma of pure type. (4012581)
1985
47
The angioarchitecture of the astroblastoma. (1222508)
1975
48
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
49
Astroblastoma of the brain with sudden death. (15406883)
1949
50
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949

Genetic Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Astroblastoma

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Pathways for genes affiliated with Astroblastoma

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Astroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0GFAP, VIM
2
Hide members
9.0GFAP, VIM

Compounds for genes affiliated with Astroblastoma

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Sources:
44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Astroblastoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1eosin449.4GFAP, VIM
2s 100449.4GFAP, VIM
3reticulin449.4GFAP, VIM
4retinaldehyde449.4VIM, GFAP
5silicone449.4GFAP, VIM
6streptozotocin449.4GFAP, VIM
7hematoxylin449.4VIM, GFAP
8ganciclovir44 1110.3GFAP, VIM
9neomycin449.3GFAP, VIM
10ganglioside449.3VIM, GFAP
11dbc-amp449.3GFAP, VIM
12chondroitin sulfate44 2410.3GFAP, VIM
13cytarabine44 49 1111.3GFAP, VIM
14cocaine44 1110.3GFAP, VIM
15bromodeoxyuridine449.2VIM, GFAP
165-hydroxytryptamine449.2GFAP, VIM
17choline44 11 2411.2GFAP, VIM
18formaldehyde44 2410.1VIM, GFAP
19isoproterenol44 1110.1GFAP, VIM
20agar449.0GFAP, VIM
21butyrate449.0GFAP, VIM
22gaba448.9VIM, GFAP
23retinoic acid44 249.8VIM, DSC1, GFAP
24matrigel448.7GFAP, VIM

GO Terms for genes affiliated with Astroblastoma

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16Gene Ontology
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Cellular components related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0GFAP, VIM

Biological processes related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.0GFAP, VIM
2negative regulation of neuron projection developmentGO:0109779.0GFAP, VIM
3astrocyte developmentGO:0140028.9GFAP, VIM
4intermediate filament organizationGO:0451098.7GFAP, VIM

Molecular functions related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0GFAP, VIM

Products for genes affiliated with Astroblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Astroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet