MCID: AST002
MIFTS: 44

Astroblastoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories
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Summaries for Astroblastoma

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NIH Rare Diseases:42 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards based summary: Astroblastoma, also known as cerebral astroblastoma, is related to ependymoma and astrocytoma. An important gene associated with Astroblastoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoplasmic microtubules. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and parietal lobe, and related mouse phenotypes are vision/eye and cellular.

Wikipedia:65 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Aliases & Classifications for Astroblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 34MeSH, 39NCIt, 57SNOMED-CT, 63UMLS via Orphanet
See all sources

Astroblastoma, Aliases & Descriptions:

Name: Astroblastoma 8 42 10 44 48 62
 
Cerebral Astroblastoma 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
astroblastoma:
Inheritance: Sporadic; Age of onset: Variable


External Ids:

Disease Ontology8 DOID:7305
MeSH34 D018302
SNOMED-CT57 48952003
NCIt39 C4324
UMLS via Orphanet63 C0334587

Related Diseases for Astroblastoma

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Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Symptoms for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Drug clinical trials:

Search ClinicalTrials for Astroblastoma

Search NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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MalaCards organs/tissues related to Astroblastoma:

32
Brain, Cerebellum, Parietal lobe, Temporal lobe, Hypothalamus, Bone, Spinal cord

Animal Models for Astroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Astroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5VIM, DSC1, GFAP
2MP:00053848.5VIM, DSC1, GFAP
3MP:00053868.4VIM, DSC1, GFAP
4MP:00053878.2GFAP, DSC1, VIM

Publications for Astroblastoma

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Articles related to Astroblastoma:

(show top 50)    (show all 67)
idTitleAuthorsYear
1
High-grade astroblastoma in a child: Report of one case and review of literature. (25101206)
2014
2
Astroblastoma: rare incidence and challenges in the pattern of care. (24607547)
2014
3
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
4
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. (23301912)
2013
5
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
6
Cerebral astroblastoma: A case report and review of literature. (22870162)
2012
7
Clinical features and post-surgical outcome of patients with astroblastoma. (21507653)
2011
8
Anaplastic astroblastoma: a rare glial tumour. (22679316)
2011
9
Astroblastoma with bone invasion. (22347336)
2011
10
A newborn with massive congenital astroblastoma. (21491993)
2011
11
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
12
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
13
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
14
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
15
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. (19214707)
2009
16
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
17
Astroblastoma in a child. (17653728)
2008
18
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. (19096646)
2008
19
Intraventricular astroblastoma. Case report. (18352788)
2008
20
Brainstem astroblastoma: a case report and review of the literature. (17765957)
2008
21
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. (18280055)
2008
22
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
23
Neuroradiologic characteristics of astroblastoma. (17216265)
2007
24
Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. (17369788)
2007
25
'Low-grade' astroblastoma with rapid recurrence: a case report. (16484017)
2006
26
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. (16636749)
2006
27
Low-grade astroblastoma recurring with extensive invasion. (16998280)
2006
28
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
29
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
30
Identification of phenotypic neural stem cells in a pediatric astroblastoma. (16302618)
2005
31
Cerebral astroblastoma. (15168232)
2004
32
Astroblastoma: diffusion MRI, and proton MR spectroscopy. (11918982)
2002
33
Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. (11847049)
2002
34
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
35
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
36
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
37
Astroblastoma: does histology predict biologic behavior? (9874187)
1998
38
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
39
Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. (8352168)
1993
40
Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. (8516227)
1993
41
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
42
The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. (2683559)
1989
43
Astroblastoma revisited: a report of three cases. (3727930)
1986
44
The fine structure of astroblastoma. (3967170)
1985
45
The angioarchitecture of the astroblastoma. (1222508)
1975
46
Clinical pathological conference; astroblastoma. (14899596)
1952
47
A study of 182 patients with verified astrocytoma, astroblastoma and oligodendroglioma of the brain. (15422396)
1950
48
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
49
Astroblastoma of the brain with sudden death. (15406883)
1949
50
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949

Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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Expression patterns in normal tissues for genes affiliated with Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for genes affiliated with Astroblastoma

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Pathways related to Astroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0VIM, GFAP
2
Show member pathways
Cytoskeleton remodeling Neurofilaments60
9.0VIM, GFAP

Compounds for genes affiliated with Astroblastoma

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Compounds related to Astroblastoma according to GeneCards/GeneDecks:

(show all 36)
idCompoundScoreTop Affiliating Genes
1eosin449.4VIM, GFAP
2s 100449.4VIM, GFAP
3reticulin449.4VIM, GFAP
4retinaldehyde449.4VIM, GFAP
5silicone449.4GFAP, VIM
6streptozotocin449.4VIM, GFAP
7hematoxylin449.4VIM, GFAP
8ganciclovir44 1110.4GFAP, VIM
9neomycin449.4VIM, GFAP
10ganglioside449.4GFAP, VIM
11dbc-amp449.4VIM, GFAP
12chondroitin sulfate44 2410.4VIM, GFAP
13cytarabine44 50 1111.4GFAP, VIM
14cocaine44 1110.4VIM, GFAP
15bromodeoxyuridine449.4VIM, GFAP
165-hydroxytryptamine449.4VIM, GFAP
17choline44 24 1111.4GFAP, VIM
18formaldehyde44 2410.4VIM, GFAP
19isoproterenol44 1110.3VIM, GFAP
20agar449.3GFAP, VIM
21gaba449.3VIM, GFAP
22matrigel449.3GFAP, VIM
23butyrate449.3VIM, GFAP
24methionine449.3VIM, GFAP
25nmda44 2810.3VIM, GFAP
26paclitaxel44 50 1111.3GFAP, VIM
27acetylcholine44 50 28 24 1113.2VIM, GFAP
28glycogen44 2410.2VIM, GFAP
29estradiol44 24 1111.2GFAP, VIM
30paraffin449.1VIM, GFAP
31forskolin44 50 1111.1GFAP, VIM
32genistein44 28 61 2 24 1114.0VIM, GFAP
33lactate449.0VIM, GFAP
34glutamine448.9VIM, GFAP
35retinoic acid44 249.9VIM, DSC1, GFAP
36iron44 249.7VIM, GFAP

GO Terms for genes affiliated with Astroblastoma

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Cellular components related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0VIM, GFAP

Biological processes related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.0VIM, GFAP
2negative regulation of neuron projection developmentGO:0109779.0VIM, GFAP
3astrocyte developmentGO:0140028.9VIM, GFAP
4intermediate filament organizationGO:0451098.7VIM, GFAP

Molecular functions related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0VIM, GFAP

Products for genes affiliated with Astroblastoma

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  • Antibodies
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Sources for Astroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet