MCID: AST002
MIFTS: 37

Astroblastoma malady

Rare diseases, Neuronal diseases, Cancer diseases categories

Summaries for Astroblastoma

About this section


NIH Rare Diseases:41 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards based summary: Astroblastoma, also known as cerebral astroblastoma, is related to ependymoma and astrocytoma. An important gene associated with Astroblastoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoplasmic microtubules. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and parietal lobe, and related mouse phenotypes are vision/eye and cellular.

Wikipedia:63 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Aliases & Classifications for Astroblastoma

About this section
Sources:
9Disease Ontology, 41NIH Rare Diseases, 11DISEASES, 43Novoseek, 47Orphanet, 60UMLS, 33MeSH, 38NCIt, 55SNOMED-CT, 61UMLS via Orphanet
See all sources

Astroblastoma, Aliases & Descriptions:

Name: Astroblastoma 9 41 11 43 47 60
 
Cerebral Astroblastoma 41


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

47
astroblastoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy


External Ids:

Disease Ontology9 DOID:7305
MeSH33 D018302
NCIt38 C4324
SNOMED-CT55 48952003
Orphanet47 251679
UMLS via Orphanet61 C0334587

Related Diseases for Astroblastoma

About this section

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Symptoms for Astroblastoma

About this section

Drugs & Therapeutics for Astroblastoma

About this section

Drug clinical trials:

Search ClinicalTrials for Astroblastoma

Search NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

About this section

Anatomical Context for Astroblastoma

About this section

MalaCards organs/tissues related to Astroblastoma:

31
Brain, Cerebellum, Parietal lobe, Temporal lobe, Hypothalamus, Bone, Spinal cord

Animal Models for Astroblastoma or affiliated genes

About this section

MGI Mouse Phenotypes related to Astroblastoma:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5VIM, DSC1, GFAP
2MP:00053848.5GFAP, DSC1, VIM
3MP:00053868.4GFAP, DSC1, VIM
4MP:00053878.2VIM, DSC1, GFAP

Publications for Astroblastoma

About this section

Articles related to Astroblastoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? (25737639)
2015
2
High-grade astroblastoma in a child: Report of one case and review of literature. (25101206)
2014
3
Astroblastoma: rare incidence and challenges in the pattern of care. (24607547)
2014
4
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
5
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. (23301912)
2013
6
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
7
Clinical features and post-surgical outcome of patients with astroblastoma. (21507653)
2011
8
Anaplastic astroblastoma: a rare glial tumour. (22679316)
2011
9
Astroblastoma with bone invasion. (22347336)
2011
10
A newborn with massive congenital astroblastoma. (21491993)
2011
11
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
12
Two cases of pediatric high-grade astroblastoma with different clinical behavior. (20437876)
2010
13
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
14
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
15
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
16
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. (19214707)
2009
17
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
18
Astroblastoma in a child. (17653728)
2008
19
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. (19096646)
2008
20
Intraventricular astroblastoma. Case report. (18352788)
2008
21
Brainstem astroblastoma: a case report and review of the literature. (17765957)
2008
22
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. (18280055)
2008
23
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
24
Neuroradiologic characteristics of astroblastoma. (17216265)
2007
25
'Low-grade' astroblastoma with rapid recurrence: a case report. (16484017)
2006
26
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. (16636749)
2006
27
Low-grade astroblastoma recurring with extensive invasion. (16998280)
2006
28
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
29
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
30
Identification of phenotypic neural stem cells in a pediatric astroblastoma. (16302618)
2005
31
Cerebral astroblastoma. (15168232)
2004
32
Astroblastoma: diffusion MRI, and proton MR spectroscopy. (11918982)
2002
33
Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. (11847049)
2002
34
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
35
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
36
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
37
Astroblastoma: does histology predict biologic behavior? (9874187)
1998
38
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
39
Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. (8352168)
1993
40
Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. (8516227)
1993
41
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
42
The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. (2683559)
1989
43
Astroblastoma revisited: a report of three cases. (3727930)
1986
44
The fine structure of astroblastoma. (3967170)
1985
45
The angioarchitecture of the astroblastoma. (1222508)
1975
46
Clinical pathological conference; astroblastoma. (14899596)
1952
47
A study of 182 patients with verified astrocytoma, astroblastoma and oligodendroglioma of the brain. (15422396)
1950
48
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
49
Astroblastoma of the brain with sudden death. (15406883)
1949
50
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949

Variations for Astroblastoma

About this section

Expression for genes affiliated with Astroblastoma

About this section
Search GEO for disease gene expression data for Astroblastoma.

Pathways for genes affiliated with Astroblastoma

About this section

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0VIM, GFAP

Compounds for genes affiliated with Astroblastoma

About this section

Compounds related to Astroblastoma according to GeneCards Suite gene sharing:

(show all 36)
idCompoundScoreTop Affiliating Genes
1eosin439.4VIM, GFAP
2s 100439.4VIM, GFAP
3reticulin439.4VIM, GFAP
4retinaldehyde439.4VIM, GFAP
5silicone439.4GFAP, VIM
6streptozotocin439.4VIM, GFAP
7hematoxylin439.4VIM, GFAP
8ganciclovir43 1210.4GFAP, VIM
9neomycin439.4VIM, GFAP
10ganglioside439.4GFAP, VIM
11dbc-amp439.4VIM, GFAP
12chondroitin sulfate43 2410.4VIM, GFAP
13cytarabine43 49 1211.4GFAP, VIM
14cocaine43 1210.4VIM, GFAP
15bromodeoxyuridine439.4VIM, GFAP
165-hydroxytryptamine439.4VIM, GFAP
17choline43 24 1211.4GFAP, VIM
18formaldehyde43 2410.4VIM, GFAP
19isoproterenol43 1210.3VIM, GFAP
20agar439.3GFAP, VIM
21gaba439.3VIM, GFAP
22matrigel439.3GFAP, VIM
23butyrate439.3VIM, GFAP
24methionine439.3VIM, GFAP
25nmda43 2810.3VIM, GFAP
26paclitaxel43 49 1211.3GFAP, VIM
27acetylcholine43 49 28 24 1213.2VIM, GFAP
28glycogen43 2410.2VIM, GFAP
29estradiol43 24 1211.2GFAP, VIM
30paraffin439.1VIM, GFAP
31forskolin43 49 1211.1GFAP, VIM
32genistein43 28 59 2 24 1214.0VIM, GFAP
33lactate439.0VIM, GFAP
34glutamine438.9VIM, GFAP
35retinoic acid43 249.9VIM, DSC1, GFAP
36iron43 249.7VIM, GFAP

GO Terms for genes affiliated with Astroblastoma

About this section

Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:00058829.0VIM, GFAP

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:00600209.0VIM, GFAP
2negative regulation of neuron projection developmentGO:00109779.0VIM, GFAP
3astrocyte developmentGO:00140028.9VIM, GFAP
4intermediate filament organizationGO:00451098.7VIM, GFAP

Molecular functions related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.0VIM, GFAP

Products for genes affiliated with Astroblastoma

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies
  • Proteins
  • Kits and Assays

Sources for Astroblastoma

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet