MCID: AST002
MIFTS: 40

Astroblastoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Astroblastoma

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Astroblastoma:

Name: Astroblastoma 10 45 47 12 51 65
 
Cerebral Astroblastoma 45

Characteristics:

Orphanet epidemiological data:

51
astroblastoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy

Classifications:



External Ids:

Disease Ontology10 DOID:7305
MeSH36 D018302
NCIt42 C4324
SNOMED-CT59 48952003
Orphanet51 251679
UMLS via Orphanet66 C0334587
UMLS65 C0334587

Summaries for Astroblastoma

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NIH Rare Diseases:45 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards based summary: Astroblastoma, also known as cerebral astroblastoma, is related to astrocytoma and conus medullaris neoplasm. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways are RB in Cancer and Citrate cycle (TCA cycle). Affiliated tissues include brain, cerebellum and temporal lobe, and related mouse phenotypes are pigmentation and tumorigenesis.

Wikipedia:68 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

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Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 158)
idRelated DiseaseScoreTop Affiliating Genes
1astrocytoma29.7GFAP, IDH1, MDM2, NES, TP53
2conus medullaris neoplasm10.9GFAP, NES
3alveoli adenoma10.8GFAP, TP53
4ovarian mucinous cystadenofibroma10.8GFAP, TP53
5urinary bladder villous adenoma10.8GFAP, SYP
6pediculus humanus capitis infestation10.8GFAP, SYP
7adult malignant schwannoma10.8GFAP, SYP
8malignant ovarian brenner tumor10.8SYP, VIM
9skin glomus tumor10.7GFAP, SYP
10breast leiomyosarcoma10.7PROM1, SMARCB1
11lateral ventricle meningioma10.7GFAP, TP53
12brain glioma10.7SYP, TP53
13thrombophlebitis10.7GFAP, SMARCB1
14childhood cerebellar neoplasm10.7GFAP, SMARCB1, VIM
15supratentorial primitive neuroectodermal tumor10.7NES, SYP
16benign ependymoma10.7GFAP, SYP
17mixed astrocytoma-ependymoma10.7IDH1, TP53
18mixed glioma10.7GFAP, SYP
19subglottic angioma10.7MDM2, TP53
20cerebral ventricle cancer10.7GFAP, SMARCB1, TP53
21anaplastic ganglioglioma10.7GFAP, MDM2
22esophageal lipoma10.7MDM2, VIM
23anovulation10.7GFAP, SYP, VIM
24spindle cell liposarcoma10.7MDM2, TP53
25melanotic neurilemmoma10.6NF1, SMARCB1
26rectum kaposi's sarcoma10.6SMARCB1, SYP
27fallopian tube serous papilloma10.6SYP, TP53
28vulval paget's disease10.6SMARCB1, TP53
29childhood infratentorial neoplasm10.6GFAP, SYP, TP53
30selective igg deficiency disease10.6GFAP, NES, SYP
31kidney rhabdoid cancer10.6SMARCB1, SYP, VIM
32head and neck carcinoma10.6GFAP, SYP, TP53
33cerebellum cancer10.6NES, TP53
34epithelioid sarcoma10.6GFAP, MDM2
35herpes simplex10.6MDM2, TP53
36congenital disorder of glycosylation, type if10.6GFAP, IDH1, TP53
37subependymal giant cell astrocytoma10.6GFAP, IDH1, TP53
38colon small cell carcinoma10.6GFAP, IDH1, TP53
39pilomyxoid astrocytoma10.6GFAP, SYP
40liver angiosarcoma10.6IDH1, SYP
41follicular infundibulum tumor10.6NF1, SYP
42middle ear disease10.6FUT4, VIM
43sympathetic neurilemmoma10.5GFAP, IDH1, SYP
44hypoplastic left heart syndrome10.5GFAP, NES, TP53
45pulmonary immaturity10.5MDM2, TP53, VIM
46pineal gland astrocytoma10.5GFAP, NF1, TP53
47paranasal sinus disease10.5GFAP, SYP, VIM
48vulvar syringoma10.5FUT4, VIM
49juvenile astrocytoma10.5GFAP, MDM2, TP53
50diencephalic astrocytomas10.5IDH1, NF1

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Symptoms for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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MalaCards organs/tissues related to Astroblastoma:

33
Brain, Cerebellum, Temporal lobe, Hypothalamus, Parietal lobe, Lung, Breast

Animal Models for Astroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Astroblastoma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.3CFH, MDM2, NF1, PROM1, TP53
2MP:00020068.2MDM2, NF1, OLIG2, PROM1, SMARCB1, TP53
3MP:00053917.8CFH, DSC1, GFAP, GJB2, NF1, OLIG2
4MP:00053867.4DSC1, ENO2, GFAP, MDM2, NF1, OLIG2
5MP:00028737.3CFH, DSC1, GFAP, GJB2, MDM2, NF1
6MP:00053857.3CFH, FUT4, GFAP, GJB2, MDM2, NF1
7MP:00053846.6DSC1, ENO2, FUT4, GFAP, GJB2, MDM2
8MP:00107686.5CFH, GFAP, GJB2, IDH1, MDM2, NF1
9MP:00053876.3CFH, DSC1, FUT4, GFAP, GJB2, IDH1
10MP:00036316.1CFH, ENO2, GFAP, GJB2, MDM2, NF1
11MP:00053785.7DSC1, ENO2, GFAP, GJB2, IDH1, MDM2

Publications for Astroblastoma

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Articles related to Astroblastoma:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. (26614252)
2016
2
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. (27048363)
2016
3
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. (26547295)
2016
4
Adult intraventricular astroblastoma. (26831319)
2016
5
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? (25737639)
2015
6
High-grade astroblastoma in a child: Report of one case and review of literature. (25101206)
2014
7
Astroblastoma: rare incidence and challenges in the pattern of care. (24607547)
2014
8
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
9
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. (23301912)
2013
10
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
11
Clinical features and post-surgical outcome of patients with astroblastoma. (21507653)
2011
12
Anaplastic astroblastoma: a rare glial tumour. (22679316)
2011
13
Astroblastoma with bone invasion. (22347336)
2011
14
A newborn with massive congenital astroblastoma. (21491993)
2011
15
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
16
Two cases of pediatric high-grade astroblastoma with different clinical behavior. (20437876)
2010
17
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
18
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
19
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
20
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. (19214707)
2009
21
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
22
Astroblastoma in a child. (17653728)
2008
23
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. (19096646)
2008
24
Intraventricular astroblastoma. Case report. (18352788)
2008
25
Brainstem astroblastoma: a case report and review of the literature. (17765957)
2008
26
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
27
Neuroradiologic characteristics of astroblastoma. (17216265)
2007
28
'Low-grade' astroblastoma with rapid recurrence: a case report. (16484017)
2006
29
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. (16636749)
2006
30
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
31
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
32
Identification of phenotypic neural stem cells in a pediatric astroblastoma. (16302618)
2005
33
Astroblastoma: diffusion MRI, and proton MR spectroscopy. (11918982)
2002
34
Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. (11847049)
2002
35
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
36
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
37
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
38
Astroblastoma: does histology predict biologic behavior? (9874187)
1998
39
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
40
Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. (8352168)
1993
41
Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. (8516227)
1993
42
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
43
The astroblastoma and its possible cytogenic relationship to the tanycyte. An electron microscopic, immunohistochemical, tissue- and organ-culture study. (2683559)
1989
44
Astroblastoma revisited: a report of three cases. (3727930)
1986
45
Clinical pathological conference; astroblastoma. (14899596)
1952
46
A study of 182 patients with verified astrocytoma, astroblastoma and oligodendroglioma of the brain. (15422396)
1950
47
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
48
Astroblastoma of the brain with sudden death. (15406883)
1949
49
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949
50

Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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Search GEO for disease gene expression data for Astroblastoma.

Pathways for genes affiliated with Astroblastoma

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GO Terms for genes affiliated with Astroblastoma

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Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:004511110.1NES, VIM

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament-based processGO:004510310.1GFAP, VIM
22-oxoglutarate metabolic processGO:00061039.6IDH1, TAT

Sources for Astroblastoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet