MCID: AST002
MIFTS: 32

Astroblastoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Astroblastoma

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Sources:
11Disease Ontology, 46NIH Rare Diseases, 13DISEASES, 52Orphanet, 48Novoseek, 66UMLS, 37MeSH, 43NCIt, 67UMLS via Orphanet, 60SNOMED-CT
See all MalaCards sources

Aliases & Descriptions for Astroblastoma:

Name: Astroblastoma 11 46 13 52 48 66
 
Cerebral Astroblastoma 46

Characteristics:

Orphanet epidemiological data:

52
astroblastoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy

Classifications:



External Ids:

Disease Ontology11 DOID:7305
MeSH37 D018302
NCIt43 C4324
SNOMED-CT60 48952003
Orphanet52 ORPHA251679
UMLS via Orphanet67 C0334587

Summaries for Astroblastoma

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NIH Rare Diseases:46 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards based summary: Astroblastoma, also known as cerebral astroblastoma, is related to empty sella syndrome and anaplastic oligodendroglioma. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways are Cytoskeleton remodeling Neurofilaments and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, cerebellum and parietal lobe.

Wikipedia:69 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

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Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 82)
idRelated DiseaseScoreTop Affiliating Genes
1empty sella syndrome10.3GFAP, NES
2anaplastic oligodendroglioma10.3GFAP, NES
3cervical alveolar soft part sarcoma10.3GFAP, NES
4cerebritis10.3
5uterine corpus epithelioid leiomyosarcoma10.2GFAP, NES
6grubben de cock borghgraef syndrome10.2GFAP, SYP
7papillary glioneuronal tumor10.2GFAP, SYP
8bladder flat intraepithelial lesion10.2GFAP, SYP
9lice infestation10.2GFAP, SYP
10chiari malformation type 410.2GFAP, SYP
11cauda equina neoplasm10.2GFAP, SYP
12glomus tumor10.2GFAP, SYP
13vulvar benign neoplasm10.2GFAP, SYP
14hypersensitivity reaction type ii disease10.2GFAP, SYP
15brainstem intraparenchymal clear cell meningioma10.2GFAP, SYP
16cervical benign neoplasm10.2GFAP, NES
17lumbar plexus neoplasm10.2GFAP, SYP
18atypical choroid plexus papilloma10.2GFAP, SYP
19pilomyxoid astrocytoma10.2GFAP, SYP
20cauda equina intradural extramedullary astrocytoma10.2GFAP, SYP
21choroid disease10.2GFAP, SYP
22vitamin metabolic disorder10.2GFAP, SYP
23pineoblastoma10.2GFAP, SYP
24plexopathy10.2GFAP, SYP
25malignant granular cell esophageal tumor10.2GFAP, SYP
26gallbladder adenoma10.2GFAP, SYP
27malignant pineal area germ cell neoplasm10.2GFAP, SYP
28diencephalic astrocytomas10.2GFAP, SYP
29pineal parenchymal tumor of intermediate differenciation10.2GFAP, SYP
30pulmonary plasma cell granuloma10.1GFAP, SYP
31sm-ahnmd10.1NES, SYP
32spinal cord glioma10.1GFAP, SYP
33large intestine lipoma10.1GFAP, SYP
34central centrifugal cicatricial alopecia10.1GFAP, SYP
35neurilemmoma of the fifth cranial nerve10.1GFAP, SYP
36peritoneal benign neoplasm10.1GFAP, SYP
37mesenchymoma10.1GFAP, SYP
38central nervous system sarcoma10.1GFAP, SYP
39adult central nervous system primitive neuroectodermal neoplasm10.0GFAP, SYP
40pediatric ependymoma10.0GFAP, SYP
41gallbladder leiomyosarcoma10.0GFAP, SYP
42trochlear nerve neoplasm10.0NES, SYP
43grade iii astrocytoma10.0GFAP, SYP
44melanotic medulloblastoma10.0GFAP, SYP
45sarcoma10.0
46arteriovenous malformation10.0
47glioma10.0
48protoplasmic astrocytoma10.0GFAP, SYP
49intestinal benign neoplasm9.9GFAP, GJB2
50central nervous system vasculitis9.9GFAP, SYP

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Symptoms for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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MalaCards organs/tissues related to Astroblastoma:

34
Brain, Cerebellum, Parietal lobe, Hypothalamus, Temporal lobe, Spinal cord, Bone

Animal Models for Astroblastoma or affiliated genes

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Publications for Astroblastoma

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Articles related to Astroblastoma:

(show top 50)    (show all 80)
idTitleAuthorsYear
1
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. (27416954)
2016
2
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. (27048363)
2016
3
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. (26547295)
2016
4
Genomic characterization of recurrent high-grade astroblastoma. (27425854)
2016
5
Astroblastoma: Case Report and Review of Literature. (27349390)
2016
6
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. (26614252)
2016
7
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? (25737639)
2015
8
Distant dissemination of mixed low-grade astroblastoma-arteriovenous malformation after initial operation: a case report. (26261652)
2015
9
Astroblastoma of cerebrum: A rare case report and review of literature. (26458709)
2015
10
High-grade astroblastoma in a child: Report of one case and review of literature. (25101206)
2014
11
Astroblastoma: rare incidence and challenges in the pattern of care. (24607547)
2014
12
Cerebral astroblastoma: A radiopathological diagnosis. (24891904)
2014
13
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
14
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. (23301912)
2013
15
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
16
Anaplastic astroblastoma: a rare glial tumour. (22679316)
2011
17
Astroblastoma with bone invasion. (22347336)
2011
18
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
19
Clinical features and post-surgical outcome of patients with astroblastoma. (21507653)
2011
20
Two cases of pediatric high-grade astroblastoma with different clinical behavior. (20437876)
2010
21
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
22
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
23
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
24
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
25
Astroblastoma in a child. (17653728)
2008
26
Intraventricular astroblastoma. Case report. (18352788)
2008
27
Brainstem astroblastoma: a case report and review of the literature. (17765957)
2008
28
Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. (18415663)
2008
29
Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. (17369788)
2007
30
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
31
'Low-grade' astroblastoma with rapid recurrence: a case report. (16484017)
2006
32
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. (16636749)
2006
33
Low-grade astroblastoma recurring with extensive invasion. (16998280)
2006
34
Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation. (16521483)
2006
35
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
36
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
37
Astroblastoma with unusual signet-ring-like cell components: a case report and literature review. (12416560)
2002
38
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
39
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
40
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
41
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
42
Astroblastoma: report of a case with ultrastructural, cell kinetic, and cytogenetic analysis. (8516227)
1993
43
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
44
The fine structure of astroblastoma. (3967170)
1985
45
Activation of acetyl- and butyrylcholinesterase by enzymatic removal of sialic acid from intact neuroblastoma and astroblastoma cells in culture. (172121)
1975
46
Clinical pathological conference; astroblastoma. (14899596)
1952
47
A study of 182 patients with verified astrocytoma, astroblastoma and oligodendroglioma of the brain. (15422396)
1950
48
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
49
Astroblastoma of the brain with sudden death. (15406883)
1949
50
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949

Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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Search GEO for disease gene expression data for Astroblastoma.

Pathways for genes affiliated with Astroblastoma

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Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

idSuper pathwaysScoreTop Affiliating Genes
1
Show member pathways
9.0GFAP, NES, TUBB
28.9GFAP, NES, SYP
38.9GFAP, SYP, TUBB

GO Terms for genes affiliated with Astroblastoma

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Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:00451119.5GFAP, NES
2cell bodyGO:00442979.5GFAP, TUBB
3intermediate filamentGO:00058829.4GFAP, NES

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1G2/M transition of mitotic cell cycleGO:00000869.4NES, TUBB

Molecular functions related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:00052009.5GFAP, TUBB
2structural molecule activityGO:00051988.9GFAP, NES, TUBB

Sources for Astroblastoma

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet