MCID: AST002
MIFTS: 31

Astroblastoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Astroblastoma

Aliases & Descriptions for Astroblastoma:

Name: Astroblastoma 12 50 56 52 14 69
Cerebral Astroblastoma 50

Characteristics:

Orphanet epidemiological data:

56
astroblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7305
MeSH 42 D018302
NCIt 47 C4324
SNOMED-CT 64 48952003
Orphanet 56 ORPHA251679
UMLS via Orphanet 70 C0334587
ICD10 via Orphanet 34 C71.9
UMLS 69 C0334587

Summaries for Astroblastoma

NIH Rare Diseases : 50 astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards based summary : Astroblastoma, also known as cerebral astroblastoma, is related to hypothalamic neoplasm and angiofollicular lymph hyperplasia. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain, cerebellum and hypothalamus.

Wikipedia : 71 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
id Related Disease Score Top Affiliating Genes
1 hypothalamic neoplasm 10.2 GFAP NES
2 angiofollicular lymph hyperplasia 10.2 GFAP NES
3 childhood kidney cell carcinoma 10.2 GFAP NES
4 childhood embryonal testis carcinoma 10.2 GFAP NES
5 diabetes hypogonadism deafness mental retardation 10.2 GFAP SYP
6 papillary tumor of the pineal region 10.2 GFAP SYP
7 osteopetrosis, autosomal recessive 8 10.2 GFAP NES
8 brain stem ependymoma 10.2 GFAP SYP
9 myelinoclastic diffuse sclerosis 10.2 ENO2 GFAP
10 intrahepatic bile duct adenoma 10.2 GFAP SYP
11 pilocytic astrocytoma of cerebellum 10.2 GFAP SYP
12 bronchiolitis obliterans 10.2 GFAP NES
13 children's interstitial lung disease 10.2 GFAP SYP
14 thrombophlebitis 10.2 ENO2 GFAP
15 cervical benign neoplasm 10.2 GFAP SYP
16 epidermal appendage tumor 10.2 GFAP SYP
17 clear cell meningioma 10.2 GFAP SYP
18 cerebral folate receptor alpha deficiency 10.2 GFAP SYP
19 pilocytic astrocytoma 10.2 GFAP SYP
20 pleomorphic xanthoastrocytoma 10.2 GFAP SYP
21 mediastinal granular cell myoblastoma 10.2 GFAP SYP
22 central neurocytoma 10.2 GFAP SYP
23 mast-cell sarcoma 10.2 GFAP SYP
24 olfactory neuroblastoma 10.2 GFAP SYP
25 jejunal somatostatinoma 10.2 ENO2 GFAP
26 pineoblastoma 10.2 GFAP SYP
27 fallopian tube benign neoplasm 10.2 GFAP NES
28 pneumothorax 10.2 GFAP SYP
29 brain stem astrocytic neoplasm 10.2 GFAP SYP
30 brain oligodendroglioma 10.2 GFAP SYP
31 arthus reaction 10.2 GFAP SYP
32 bone dysplasia azouz type 10.2 GFAP SYP
33 pancreatic cancer 10.2 GFAP SYP
34 heavy chain disease 10.2 ENO2 GFAP
35 pacinian tumor 10.2 GFAP SYP
36 temporal lobe neoplasm 10.2 GFAP SYP
37 melanotic neurilemmoma 10.2 GFAP SYP
38 infiltrating renal pelvis transitional cell carcinoma 10.2 ENO2 SYP
39 thymus small cell carcinoma 10.2 ENO2 SYP
40 skeletal-extraskeletal angiomatosis 10.2 ENO2 SYP
41 prolactin producing pituitary tumor 10.2 ENO2 SYP
42 glomus tumor 10.2 ENO2 SYP
43 pemphigus foliaceus 10.2 ENO2 SYP
44 spasmodic dysphonia 10.2 ENO2 SYP
45 pneumonia 10.2 ENO2 GFAP
46 cerebritis 10.2
47 ampullary signet ring cell adenocarcinoma 10.2 ENO2 SYP
48 focal cortical dysplasia, taylor balloon cell type 10.2 GFAP SYP
49 perineural angioma 10.2 ENO2 SYP
50 gliofibroma 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to Astroblastoma

Symptoms & Phenotypes for Astroblastoma

Drugs & Therapeutics for Astroblastoma

Search Clinical Trials , NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

Anatomical Context for Astroblastoma

MalaCards organs/tissues related to Astroblastoma:

39
Brain, Cerebellum, Hypothalamus, Temporal Lobe, Parietal Lobe, Bone, Spinal Cord

Publications for Astroblastoma

Articles related to Astroblastoma:

(show top 50) (show all 80)
id Title Authors Year
1
Genomic characterization of recurrent high-grade astroblastoma. ( 27425854 )
2016
2
Astroblastoma: Case Report and Review of Literature. ( 27349390 )
2016
3
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. ( 26614252 )
2016
4
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. ( 27416954 )
2016
5
Adult intraventricular astroblastoma. ( 26831319 )
2016
6
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. ( 27048363 )
2016
7
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. ( 26547295 )
2016
8
Distant dissemination of mixed low-grade astroblastoma-arteriovenous malformation after initial operation: a case report. ( 26261652 )
2015
9
Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature. ( 26227256 )
2015
10
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? ( 25737639 )
2015
11
Astroblastoma of cerebrum: A rare case report and review of literature. ( 26458709 )
2015
12
Intraventricular Astroblastoma in an Infant: A Case Report and Review of the Literature. ( 26406441 )
2015
13
Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. ( 25108699 )
2014
14
Cerebral astroblastoma: A radiopathological diagnosis. ( 24891904 )
2014
15
Astroblastoma: rare incidence and challenges in the pattern of care. ( 24607547 )
2014
16
High-grade astroblastoma in a child: Report of one case and review of literature. ( 25101206 )
2014
17
Cerebral astroblastoma in an adult: an immunohistochemical, ultrastructural and genetic study. ( 22994361 )
2013
18
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. ( 23301912 )
2013
19
Mixed astroblastoma-arteriovenous malformation complex: a case report. ( 24005749 )
2013
20
Cerebral astroblastoma: A case report and review of literature. ( 22870162 )
2012
21
Pediatric astroblastoma: a rare case with a review of the literature. ( 23038221 )
2012
22
Astroblastoma - a case report of a rare neuroepithelial tumor with complete remission after chemotherapy. ( 22011735 )
2011
23
Anaplastic astroblastoma: a rare glial tumour. ( 22679316 )
2011
24
Astroblastoma with bone invasion. ( 22347336 )
2011
25
A newborn with massive congenital astroblastoma. ( 21491993 )
2011
26
Clinical features and post-surgical outcome of patients with astroblastoma. ( 21507653 )
2011
27
Recurrent astroblastoma treated with gamma knife radiosurgery. ( 20938716 )
2011
28
Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1. ( 20860891 )
2010
29
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. ( 21540623 )
2010
30
Two cases of pediatric high-grade astroblastoma with different clinical behavior. ( 20437876 )
2010
31
Supratentorial high grade astroblastoma: report of two cases and review of the literature. ( 19431125 )
2009
32
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. ( 18958463 )
2009
33
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. ( 19214707 )
2009
34
Anaplastic astroblastoma of childhood: aggressive behavior. ( 19357852 )
2009
35
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. ( 19096646 )
2008
36
Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. ( 18415663 )
2008
37
Brainstem astroblastoma: a case report and review of the literature. ( 17765957 )
2008
38
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. ( 18280055 )
2008
39
Astroblastoma in a child. ( 17653728 )
2008
40
Intraventricular astroblastoma. Case report. ( 18352788 )
2008
41
An astroblastoma mimicking a cavernous malformation: case report. ( 17327764 )
2007
42
Astroblastoma presenting with intracerebral hemorrhage misdiagnosed as dural arteriovenous fistula: review of a rare entity. ( 17320647 )
2007
43
Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. ( 17369788 )
2007
44
Malignant astroblastoma with rhabdoid morphology. ( 17332948 )
2007
45
Neuroradiologic characteristics of astroblastoma. ( 17216265 )
2007
46
Low-grade astroblastoma recurring with extensive invasion. ( 16998280 )
2006
47
An astroblastoma case associated with loss of heterozygosity on chromosome 9p. ( 16636749 )
2006
48
Astroblastoma: immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation. ( 16521483 )
2006
49
Complete surgical resection of high-grade astroblastoma with long time survival: case report and review of the literature. ( 16565782 )
2006
50
'Low-grade' astroblastoma with rapid recurrence: a case report. ( 16484017 )
2006

Variations for Astroblastoma

Expression for Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for Astroblastoma

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 11.84 ENO2 GFAP SYP
2
Show member pathways
11.17 GFAP NES VIM
3 10.83 GFAP NES SYP VIM

GO Terms for Astroblastoma

Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.96 GFAP NES
2 intermediate filament GO:0005882 8.8 GFAP NES VIM

Sources for Astroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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