MCID: AST002
MIFTS: 40

Astroblastoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Astroblastoma

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Sources:
42NIH Rare Diseases, 63Wikipedia, 32MalaCards
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NIH Rare Diseases:42 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards: Astroblastoma, also known as cerebral astroblastoma, is related to oligodendroglioma and cerebritis. An important gene associated with Astroblastoma is GFAP (glial fibrillary acidic protein), and among its related pathways are Spinal Cord Injury and Cytoskeleton remodeling Neurofilaments. The compounds eosin and s 100 have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and parietal lobe, and related mouse phenotype vision/eye.

Wikipedia:63 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Aliases & Classifications for Astroblastoma

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Characteristics (Orphanet epidemiological data):

48
astroblastoma:
Inheritance: Sporadic; Age of onset: Variable


Aliases & Descriptions:

astroblastoma 8 42 10 44 48 60
cerebral astroblastoma 42


External Ids:

Disease Ontology8 DOID:7305
NCIt39 C4324
SNOMED-CT56 48952003
MeSH34 D018302
SNOMED-CT via Orphanet57 48952003

Related Diseases for Astroblastoma

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Clinical Features for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Astroblastoma

Drug clinical trials:

Search ClinicalTrials for Astroblastoma

Search NIH Clinical Center for Astroblastoma

Search CenterWatch for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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32MalaCards
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MalaCards organs/tissues related to Astroblastoma:

32
Brain, Cerebellum, Parietal lobe, Temporal lobe, Hypothalamus, Bone, Spinal cord

Animal Models for Astroblastoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Astroblastoma:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053918.5GFAP, DSC1, VIM

Publications for Astroblastoma

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50PubMed
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Articles related to Astroblastoma:

(show top 50)    (show all 64)
idTitleAuthorsYear
1
Mixed astroblastoma-arteriovenous malformation complex: a case report. (24005749)
2013
2
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. (23301912)
2013
3
Cerebral astroblastoma in an adult: an immunohistochemical, ultrastructural and genetic study. (22994361)
2013
4
Pediatric astroblastoma: a rare case with a review of the literature. (23038221)
2012
5
Cerebral astroblastoma: A case report and review of literature. (22870162)
2012
6
Astroblastoma with bone invasion. (22347336)
2011
7
A newborn with massive congenital astroblastoma. (21491993)
2011
8
Recurrent astroblastoma treated with gamma knife radiosurgery. (20938716)
2011
9
Astroblastoma - a case report of a rare neuroepithelial tumor with complete remission after chemotherapy. (22011735)
2011
10
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. (21540623)
2010
11
Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1. (20860891)
2010
12
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. (18958463)
2009
13
Supratentorial high grade astroblastoma: report of two cases and review of the literature. (19431125)
2009
14
Anaplastic astroblastoma of childhood: aggressive behavior. (19357852)
2009
15
Astroblastoma in a child. (17653728)
2008
16
Intraventricular astroblastoma. Case report. (18352788)
2008
17
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. (18280055)
2008
18
Malignant astroblastoma with rhabdoid morphology. (17332948)
2007
19
Astroblastoma. Case report, review of the literature, and analysis of treatment strategies. (17369788)
2007
20
Astroblastoma presenting with intracerebral hemorrhage misdiagnosed as dural arteriovenous fistula: review of a rare entity. (17320647)
2007
21
'Low-grade' astroblastoma with rapid recurrence: a case report. (16484017)
2006
22
Low-grade astroblastoma recurring with extensive invasion. (16998280)
2006
23
Complete surgical resection of high-grade astroblastoma with long time survival: case report and review of the literature. (16565782)
2006
24
Low-grade glial tumor with features of astroblastoma in a dog. (15872386)
2005
25
Astroblastoma in childhood: pathological and clinical analysis. (15654633)
2005
26
Identification of phenotypic neural stem cells in a pediatric astroblastoma. (16302618)
2005
27
Cerebral astroblastoma. (15168232)
2004
28
Astroblastoma: a case report. (15483362)
2004
29
Brainstem astroblastoma. (15367808)
2004
30
Astroblastoma: diffusion MRI, and proton MR spectroscopy. (11918982)
2002
31
Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma. (11847049)
2002
32
Astroblastoma: report of a case with microsatellite analysis. (11132940)
2000
33
Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization. (10885653)
2000
34
Astroblastoma: ultrastructural observations on a case of high-grade type. (10582270)
1999
35
Astroblastoma: does histology predict biologic behavior? (9874187)
1998
36
Cerebral astroblastoma resembling an extra-axial neoplasm. (8767917)
1996
37
Congenital astroblastoma: an immunohistochemical study. Case report. (7545227)
1995
38
Predominantly extraaxial astroblastoma: imaging and proton MR spectroscopy features. (8352168)
1993
39
Astroblastoma: electron microscopy and immunohistochemical findings: case report. (1990478)
1991
40
Astroblastoma revisited: a report of three cases. (3727930)
1986
41
Cerebral astroblastoma: immunohistochemical and ultrastructural features. Case report. (3950749)
1986
42
The fine structure of astroblastoma. (3967170)
1985
43
Astroblastoma of pure type. (4012581)
1985
44
The angioarchitecture of the astroblastoma. (1222508)
1975
45
Activation of acetyl- and butyrylcholinesterase by enzymatic removal of sialic acid from intact neuroblastoma and astroblastoma cells in culture. (172121)
1975
46
Clinical pathological conference; astroblastoma. (14899596)
1952
47
A study of 182 patients with verified astrocytoma, astroblastoma and oligodendroglioma of the brain. (15422396)
1950
48
Astroblastoma and perithelial sarcoma in a case of neoplastic disease of the brain. (18125890)
1949
49
Astroblastoma of the brain with sudden death. (15406883)
1949
50
Astroblastoma of the cerebellum in an infant; report of a case. (18134318)
1949

Genetic Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Astroblastoma

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Pathways for genes affiliated with Astroblastoma

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37NCBI BioSystems Database, 12EMD Millipore
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Pathways related to Astroblastoma according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.0GFAP, VIM
2
Hide members
9.0GFAP, VIM

Compounds for genes affiliated with Astroblastoma

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44Novoseek, 11DrugBank, 24HMDB, 49PharmGKB
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Compounds related to Astroblastoma according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1eosin449.4GFAP, VIM
2s 100449.4GFAP, VIM
3reticulin449.4GFAP, VIM
4retinaldehyde449.4VIM, GFAP
5silicone449.4GFAP, VIM
6streptozotocin449.4GFAP, VIM
7hematoxylin449.4VIM, GFAP
8ganciclovir44 1110.3GFAP, VIM
9neomycin449.3GFAP, VIM
10ganglioside449.3VIM, GFAP
11dbc-amp449.3GFAP, VIM
12chondroitin sulfate44 2410.3GFAP, VIM
13cytarabine44 49 1111.3GFAP, VIM
14cocaine44 1110.3GFAP, VIM
15bromodeoxyuridine449.2VIM, GFAP
165-hydroxytryptamine449.2GFAP, VIM
17choline44 11 2411.2GFAP, VIM
18formaldehyde44 2410.1VIM, GFAP
19isoproterenol44 1110.1GFAP, VIM
20agar449.0GFAP, VIM
21butyrate449.0GFAP, VIM
22gaba448.9VIM, GFAP
23retinoic acid44 249.8VIM, DSC1, GFAP
24matrigel448.7GFAP, VIM

GO Terms for genes affiliated with Astroblastoma

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16Gene Ontology
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Cellular components related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1intermediate filamentGO:0058829.0GFAP, VIM

Biological processes related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Bergmann glial cell differentiationGO:0600209.0GFAP, VIM
2negative regulation of neuron projection developmentGO:0109779.0GFAP, VIM
3astrocyte developmentGO:0140028.9GFAP, VIM
4intermediate filament organizationGO:0451098.7GFAP, VIM

Molecular functions related to Astroblastoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1structural constituent of cytoskeletonGO:0052009.0GFAP, VIM

Products for genes affiliated with Astroblastoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Astroblastoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet