MCID: AST002
MIFTS: 35

Astroblastoma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Astroblastoma

MalaCards integrated aliases for Astroblastoma:

Name: Astroblastoma 12 49 55 51 14 69
Cerebral Astroblastoma 49

Characteristics:

Orphanet epidemiological data:

55
astroblastoma
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy;

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:7305
MeSH 41 D018302
NCIt 46 C4324
SNOMED-CT 64 48952003
Orphanet 55 ORPHA251679
UMLS via Orphanet 70 C0334587
ICD10 via Orphanet 33 C71.9
UMLS 69 C0334587

Summaries for Astroblastoma

NIH Rare Diseases : 49 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. It can occur in individuals of any age, but occurs predominantly in children and young adults. Signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. Because these tumors are rare, there is little known regarding their behavior and how they should be managed. Gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. Adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). Last updated: 9/4/2012

MalaCards based summary : Astroblastoma, also known as cerebral astroblastoma, is related to oligodendroglioma and ependymoma. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways/superpathways are Neuroscience and Cytoskeleton remodeling Neurofilaments. Affiliated tissues include brain, cerebellum and parietal lobe.

Wikipedia : 72 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.5 ENO2 GFAP SYP
2 ependymoma 28.9 GFAP NES SYP VIM
3 astrocytoma 28.8 GFAP NES SYP VIM
4 intracranial cysts 10.3 ENO2 GFAP
5 melanotic medulloblastoma 10.3 ENO2 GFAP
6 cerebellar medulloblastoma 10.3 ENO2 GFAP
7 plexiform schwannoma 10.3 ENO2 GFAP
8 bednar tumor 10.3 ENO2 VIM
9 integumentary system benign neoplasm 10.3 ENO2 GFAP
10 epulis 10.3 ENO2 VIM
11 ossifying fibromyxoid tumor 10.3 ENO2 VIM
12 epithelioid leiomyosarcoma 10.3 ENO2 VIM
13 cerebritis 10.3
14 traumatic brain injury 10.3 ENO2 GFAP
15 central nervous system teratoma 10.3 GFAP NES
16 anaplastic ganglioglioma 10.3 GFAP NES
17 dysgerminoma of ovary 10.3 ENO2 GFAP
18 cutaneous leiomyosarcoma 10.3 GFAP VIM
19 chondroid chordoma 10.3 ENO2 VIM
20 parachordoma 10.3 GFAP VIM
21 central nervous system germ cell tumor 10.3 GFAP NES
22 clear cell meningioma 10.2 GFAP VIM
23 syringocystadenoma papilliferum 10.2 GFAP VIM
24 juvenile pilocytic astrocytoma 10.2 ENO2 GFAP
25 myxopapillary ependymoma 10.2 GFAP VIM
26 syringoma 10.2 GFAP VIM
27 malignant sertoli cell tumor 10.2 ENO2 SYP
28 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
29 congenital epulis 10.2 ENO2 VIM
30 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
31 auditory system cancer 10.2 ENO2 SYP
32 cutaneous ganglioneuroma 10.2 ENO2 SYP
33 sensory organ benign neoplasm 10.2 ENO2 SYP
34 middle ear adenoma 10.2 ENO2 SYP
35 gallbladder small cell carcinoma 10.2 ENO2 SYP
36 liver angiosarcoma 10.2 ENO2 VIM
37 pancreatic somatostatinoma 10.2 ENO2 SYP
38 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
39 small cell carcinoma of the bladder 10.2 ENO2 SYP
40 perineurioma 10.2 GFAP VIM
41 gliomatosis cerebri 10.2 GFAP NES
42 orbital cancer 10.2 ENO2 SYP
43 brain ischemia 10.2 GFAP NES
44 brain injury 10.2 ENO2 GFAP
45 ovarian carcinosarcoma 10.2 ENO2 SYP
46 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
47 atypical follicular adenoma 10.2 ENO2 SYP
48 cerebellum cancer 10.2 ENO2 SYP
49 olfactory nerve neoplasm 10.2 ENO2 SYP
50 cauda equina neoplasm 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to Astroblastoma

Symptoms & Phenotypes for Astroblastoma

Drugs & Therapeutics for Astroblastoma

Search Clinical Trials , NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

Anatomical Context for Astroblastoma

MalaCards organs/tissues related to Astroblastoma:

38
Brain, Cerebellum, Parietal Lobe, Hypothalamus, Temporal Lobe, Spinal Cord, Bone

Publications for Astroblastoma

Articles related to Astroblastoma:

(show top 50) (show all 89)
# Title Authors Year
1
The use of 5-aminolevulinic acid to assist gross total resection of pediatric astroblastoma. ( 29305683 )
2018
2
Characterization of stem-like cells in a new astroblastoma cell line. ( 28232116 )
2017
3
Astroblastoma in a Young Female Patient: A Case Report and Literature Review of Clinicopathological, Radiological and Prognostic Characteristics and Current Treatment Strategies. ( 29188215 )
2017
4
Erratum: A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. ( 29259838 )
2017
5
Astroblastoma: a distinct tumor entity characterized by alterations of the X chromosome and MN1 rearrangement. ( 28990708 )
2017
6
Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases. ( 28477040 )
2017
7
A Pediatric Tumor Found Frequently in the Adult Population: A Case of Anaplastic Astroblastoma in an Elderly Patient and Review of the Literature. ( 28239500 )
2017
8
Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. ( 28960623 )
2017
9
A case of astroblastoma: Radiological and histopathological characteristics and a review of current treatment options. ( 28144474 )
2016
10
Adult intraventricular astroblastoma. ( 26831319 )
2016
11
Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications. ( 27048363 )
2016
12
Hemorrhage in astroblastoma: An unusual manifestation of an extremely rare entity. ( 26547295 )
2016
13
Genomic characterization of recurrent high-grade astroblastoma. ( 27425854 )
2016
14
Astroblastoma: Case Report and Review of Literature. ( 27349390 )
2016
15
A case of cerebral astroblastoma with rhabdoid features: a cytological, histological, and immunohistochemical study. ( 26614252 )
2016
16
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults. ( 27416954 )
2016
17
Astroblastoma of cerebrum: A rare case report and review of literature. ( 26458709 )
2015
18
Well-differentiated and anaplastic astroblastoma in the same patient: a case report and review of the literature. ( 26227256 )
2015
19
Distant dissemination of mixed low-grade astroblastoma-arteriovenous malformation after initial operation: a case report. ( 26261652 )
2015
20
Intraventricular Astroblastoma in an Infant: A Case Report and Review of the Literature. ( 26406441 )
2015
21
Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas? ( 25737639 )
2015
22
Astroblastoma: report of two cases with unexpected clinical behavior and review of the literature. ( 25108699 )
2014
23
Astroblastoma: rare incidence and challenges in the pattern of care. ( 24607547 )
2014
24
High-grade astroblastoma in a child: Report of one case and review of literature. ( 25101206 )
2014
25
Cerebral astroblastoma: A radiopathological diagnosis. ( 24891904 )
2014
26
Cerebral astroblastoma in an adult: an immunohistochemical, ultrastructural and genetic study. ( 22994361 )
2013
27
Recurrent low-grade astroblastoma with signet ring-like cells and high proliferative index. ( 23301912 )
2013
28
Mixed astroblastoma-arteriovenous malformation complex: a case report. ( 24005749 )
2013
29
Pediatric astroblastoma: a rare case with a review of the literature. ( 23038221 )
2012
30
Cerebral astroblastoma: A case report and review of literature. ( 22870162 )
2012
31
Anaplastic astroblastoma: a rare glial tumour. ( 22679316 )
2011
32
Recurrent astroblastoma treated with gamma knife radiosurgery. ( 20938716 )
2011
33
Astroblastoma - a case report of a rare neuroepithelial tumor with complete remission after chemotherapy. ( 22011735 )
2011
34
Astroblastoma with bone invasion. ( 22347336 )
2011
35
Clinical features and post-surgical outcome of patients with astroblastoma. ( 21507653 )
2011
36
A newborn with massive congenital astroblastoma. ( 21491993 )
2011
37
Two cases of pediatric high-grade astroblastoma with different clinical behavior. ( 20437876 )
2010
38
Anaplastic astroblastoma-sarcoma in neurofibromatosis Type 1. ( 20860891 )
2010
39
Anaplastic astroblastoma presenting as massive, sudden-onset, intraparenchymal hemorrhage. ( 21540623 )
2010
40
Supratentorial high grade astroblastoma: report of two cases and review of the literature. ( 19431125 )
2009
41
Unusual manifestations of astroblastoma: a radiologic-pathologic analysis. ( 18958463 )
2009
42
Anaplastic astroblastoma of childhood: aggressive behavior. ( 19357852 )
2009
43
Cerebral astroblastoma: analysis of six cases and critical review of treatment options. ( 19214707 )
2009
44
Brainstem astroblastoma: a case report and review of the literature. ( 17765957 )
2008
45
Intraventricular astroblastoma. Case report. ( 18352788 )
2008
46
A Cerebral Astroblastoma Mimicking an Extra-axial Neoplasm. ( 19096646 )
2008
47
Astroblastoma with rhabdoid features and favorable long-term outcome: report of a case with a 12-year follow-up. ( 18280055 )
2008
48
Astroblastoma in a child. ( 17653728 )
2008
49
Consecutive histological changes in an astroblastoma that disseminated to the spinal cord after repeated intracranial recurrences: a case report. ( 18415663 )
2008
50
Malignant astroblastoma with rhabdoid morphology. ( 17332948 )
2007

Variations for Astroblastoma

Expression for Astroblastoma

Search GEO for disease gene expression data for Astroblastoma.

Pathways for Astroblastoma

Pathways related to Astroblastoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.86 ENO2 GFAP SYP
2
Show member pathways
11.17 GFAP NES VIM
3 10.82 GFAP NES SYP VIM

GO Terms for Astroblastoma

Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell body GO:0044297 9.26 GFAP GJB2
2 intermediate filament cytoskeleton GO:0045111 9.16 GFAP NES
3 intermediate filament GO:0005882 9.13 GFAP NES VIM
4 astrocyte projection GO:0097449 8.62 GFAP GJB2

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of neuron projection development GO:0010977 9.32 GFAP VIM
2 astrocyte development GO:0014002 9.26 GFAP VIM
3 intermediate filament organization GO:0045109 9.16 GFAP VIM
4 Bergmann glial cell differentiation GO:0060020 8.96 GFAP VIM
5 intermediate filament-based process GO:0045103 8.62 GFAP VIM

Molecular functions related to Astroblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.26 GFAP GJB2 SYP VIM
2 structural molecule activity GO:0005198 8.8 GFAP NES VIM

Sources for Astroblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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