MCID: AST002
MIFTS: 37

Astroblastoma malady

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Astroblastoma

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Sources:
10Disease Ontology, 45NIH Rare Diseases, 47Novoseek, 12DISEASES, 51Orphanet, 65UMLS, 36MeSH, 42NCIt, 59SNOMED-CT, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Astroblastoma:

Name: Astroblastoma 10 45 47 12 51 65
 
Cerebral Astroblastoma 45

Characteristics:

Orphanet epidemiological data:

51
astroblastoma:
Inheritance: Not applicable; Prevalence: <1/1000000 (Europe); Age of onset: Adolescent,Adult,Childhood,Infancy

Classifications:



External Ids:

Disease Ontology10 DOID:7305
MeSH36 D018302
NCIt42 C4324
SNOMED-CT59 48952003
Orphanet51 251679
UMLS via Orphanet66 C0334587
UMLS65 C0334587

Summaries for Astroblastoma

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NIH Rare Diseases:45 Astroblastoma is a rare glial tumor usually located in the cerebral hemisphere of the brain. it can occur in individuals of any age, but occurs predominantly in children and young adults. signs and symptoms depend on the location and size of the tumor but most commonly include headaches and seizures. because these tumors are rare, there is little known regarding their behavior and how they should be managed. gross total resection (complete removal) of the tumor is recommended and is associated with a good prognosis for low-grade tumors. adjuvant therapy, including radiation and/or chemotherapy, is recommended for high-grade and recurrent cases (although its effectiveness is controversial). last updated: 9/4/2012

MalaCards based summary: Astroblastoma, also known as cerebral astroblastoma, is related to kidney cancer and conus medullaris neoplasm. An important gene associated with Astroblastoma is GFAP (Glial Fibrillary Acidic Protein), and among its related pathways are RB in Cancer and Citrate cycle (TCA cycle). Affiliated tissues include brain, temporal lobe and cerebellum, and related mouse phenotypes are pigmentation and tumorigenesis.

Wikipedia:68 Astroblastoma is a rare glial tumor derived from the astroblast, a type of cell that closely resembles... more...

Related Diseases for Astroblastoma

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Diseases related to Astroblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 210)
idRelated DiseaseScoreTop Affiliating Genes
1kidney cancer29.9ENO2, MDM2, SYP, TP53
2conus medullaris neoplasm10.6GFAP, NES
3alveoli adenoma10.6GFAP, TP53
4ovarian mucinous cystadenofibroma10.5GFAP, TP53
5urinary bladder villous adenoma10.5GFAP, SYP
6pediculus humanus capitis infestation10.5GFAP, SYP
7adult malignant schwannoma10.5GFAP, SYP
8malignant ovarian brenner tumor10.5SYP, VIM
9skin glomus tumor10.5GFAP, SYP
10breast leiomyosarcoma10.5PROM1, SMARCB1
11lateral ventricle meningioma10.5GFAP, TP53
12brain glioma10.5SYP, TP53
13thrombophlebitis10.5GFAP, SMARCB1
14childhood cerebellar neoplasm10.5GFAP, SMARCB1, VIM
15supratentorial primitive neuroectodermal tumor10.5NES, SYP
16benign ependymoma10.5GFAP, SYP
17mixed astrocytoma-ependymoma10.5IDH1, TP53
18mixed glioma10.5GFAP, SYP
19subglottic angioma10.5MDM2, TP53
20cerebral ventricle cancer10.4GFAP, SMARCB1, TP53
21anaplastic ganglioglioma10.4GFAP, MDM2
22esophageal lipoma10.4MDM2, VIM
23anovulation10.4GFAP, SYP, VIM
24spindle cell liposarcoma10.4MDM2, TP53
25melanotic neurilemmoma10.4NF1, SMARCB1
26rectum kaposi's sarcoma10.4SMARCB1, SYP
27fallopian tube serous papilloma10.4SYP, TP53
28vulval paget's disease10.4SMARCB1, TP53
29childhood infratentorial neoplasm10.4GFAP, SYP, TP53
30selective igg deficiency disease10.4GFAP, NES, SYP
31kidney rhabdoid cancer10.4SMARCB1, SYP, VIM
32head and neck carcinoma10.4GFAP, SYP, TP53
33cerebellum cancer10.4NES, TP53
34epithelioid sarcoma10.4GFAP, MDM2
35herpes simplex10.4MDM2, TP53
36congenital disorder of glycosylation, type if10.4GFAP, IDH1, TP53
37subependymal giant cell astrocytoma10.4GFAP, IDH1, TP53
38colon small cell carcinoma10.4GFAP, IDH1, TP53
39pilomyxoid astrocytoma10.4GFAP, SYP
40liver angiosarcoma10.4IDH1, SYP
41follicular infundibulum tumor10.4NF1, SYP
42middle ear disease10.4FUT4, VIM
43sympathetic neurilemmoma10.4GFAP, IDH1, SYP
44hypoplastic left heart syndrome10.4GFAP, NES, TP53
45pulmonary immaturity10.3MDM2, TP53, VIM
46pineal gland astrocytoma10.3GFAP, NF1, TP53
47paranasal sinus disease10.3GFAP, SYP, VIM
48vulvar syringoma10.3FUT4, VIM
49juvenile astrocytoma10.3GFAP, MDM2, TP53
50diencephalic astrocytomas10.3IDH1, NF1

Graphical network of the top 20 diseases related to Astroblastoma:



Diseases related to astroblastoma

Symptoms for Astroblastoma

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Drugs & Therapeutics for Astroblastoma

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Interventional clinical trials:

Search ClinicalTrials, NIH Clinical Center for Astroblastoma

Genetic Tests for Astroblastoma

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Anatomical Context for Astroblastoma

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MalaCards organs/tissues related to Astroblastoma:

33
Brain, Temporal lobe, Cerebellum, Parietal lobe, Hypothalamus, Neutrophil, Pons

Animal Models for Astroblastoma or affiliated genes

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MGI Mouse Phenotypes related to Astroblastoma:

38 (show all 12)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.3CFH, MDM2, NF1, PROM1, TP53
2MP:00020068.2MDM2, NF1, OLIG2, PROM1, SMARCB1, TP53
3MP:00053917.8CFH, DSC1, GFAP, GJB2, NF1, OLIG2
4MP:00053867.4DSC1, ENO2, GFAP, MDM2, NF1, OLIG2
5MP:00028737.3CFH, DSC1, GFAP, GJB2, MDM2, NF1
6MP:00053857.3CFH, FUT4, GFAP, GJB2, MDM2, NF1
7MP:00053846.6DSC1, ENO2, FUT4, GFAP, GJB2, MDM2
8MP:00107686.5CFH, GFAP, GJB2, IDH1, MDM2, NF1
9MP:00053876.3CFH, DSC1, FUT4, GFAP, GJB2, IDH1
10MP:00036316.1CFH, ENO2, GFAP, GJB2, MDM2, NF1
11MP:00053785.7DSC1, ENO2, GFAP, GJB2, IDH1, MDM2

Publications for Astroblastoma

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Articles related to Astroblastoma:

(show top 50)    (show all 69)
idTitleAuthorsYear
1
A teenager presents with fulminant hepatic failure and acute hemolytic anemia. (25732451)
2015
2
Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma. (25649006)
2015
3
Subunit composition of VRAC channels determines substrate specificity and cellular resistance to Pt-based anti-cancer drugs. (26530471)
2015
4
A Diagnostic Conundrum: Ectopic Nasal Ossification, Submucosal Alveolar Cleft, Absent Posterior Atlantal Arch, and Corpus Callosum Lipoma. (25291089)
2014
5
MLPA based detection of mutations in the dystrophin gene of 180 Polish families with Duchenne/Becker muscular dystrophy. (25482253)
2014
6
A mutation in TP63 causing a mild ectodermal dysplasia phenotype. (24675753)
2014
7
Investigating the structure and dynamics of the PIK3CA wild-type and H1047R oncogenic mutant. (25340423)
2014
8
Paraoxonase (PON)1 Q192R functional genotypes and PON1 Q192R genotype by smoking interactions are risk factors for the metabolic syndrome, but not overweight or obesity. (25037113)
2014
9
Different utilizable substrates have different effects on cometabolic fate of imidacloprid in Stenotrophomonas maltophilia. (23053094)
2013
10
Palliation of pancreatic ductal obstruction in pancreatic cancer. (24079797)
2013
11
Resolution of translation start site for the human Kell glycoprotein. (23721226)
2013
12
Primary progressive aphasia: from syndrome to disease. (22703637)
2013
13
Beneficial effect of a synthetic prostacyclin agonist, ONO-1301, in rat autoimmune myocarditis model. (23219794)
2013
14
Bilateral temporal lobe agenesis with bilateral arachnoid cysts - a rare congenital anomaly. (23612653)
2013
15
Multiple coregulatory control of tyrosine hydroxylase gene transcription. (21368136)
2011
16
Discrimination between sclerosing cholangitis-associated autoimmune pancreatitis and primary sclerosing cholangitis, cancer using intraductal ultrasonography. (21198911)
2011
17
Respiratory modulation of muscle sympathetic nerve activity is not increased in essential hypertension or chronic obstructive pulmonary disease. (21844003)
2011
18
Exploring DRD4 and its interaction with SLC6A3 as possible risk factors for adult ADHD: a meta-analysis in four European populations. (21595008)
2011
19
Induction of neutrophil degranulation by S100A9 via a MAPK-dependent mechanism. (20103766)
2010
20
The effect of UGT1A1 promoter polymorphism on bilirubin response to hydroxyurea therapy in hemoglobinopathies. (20709051)
2010
21
Umbilical surgical scar and vulval metastasis secondary to advanced cervical squamous cell carcinoma: a report of two cases. (19789888)
2010
22
Alpha-synuclein mediates alterations in membrane conductance: a potential role for alpha-synuclein oligomers in cell vulnerability. (20550572)
2010
23
Increased xanthine oxidase activity in idiopathic pulmonary arterial hypertension. (19567609)
2009
24
Clinical features, surgical treatment, and long-term outcome in adult patients with moyamoya disease. Clinical article. (19374496)
2009
25
Effect of atorvastatin on the pharmacokinetics and pharmacodynamics of prasugrel and clopidogrel in healthy subjects. (19025429)
2008
26
Analysis of single nucleotide polymorphisms of FSH receptor gene suggests association with testicular cancer susceptibility. (18430895)
2008
27
Infant botulism: two recent cases and literature review. (18984848)
2008
28
Glycogen synthase kinase 3beta modulates synphilin-1 ubiquitylation and cellular inclusion formation by SIAH: implications for proteasomal function and Lewy body formation. (16174773)
2005
29
Granulocyte and monocyte adsorption apheresis in Korean conventional treatment-refractory patients with active ulcerative colitis: a prospective open-label multicenter study]. (15665566)
2005
30
Coexistence of copy number changes of different genes (INK4A, erbB-1, erbB-2, CMYC, CCND1 and ZNF217) in urothelial tumors. (15897688)
2005
31
Treatment of Gastrointestinal Acute Graft-Versus-Host Disease. (15913514)
2005
32
The mouse kinome: discovery and comparative genomics of all mouse protein kinases. (15289607)
2004
33
Effects of cigarette smoking and exposure to cadmium and lead on phenotypic variability of hepatic CYP2A6 and renal function biomarkers in men. (15388242)
2004
34
Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. (12576524)
2003
35
Another case of acute poststreptococcal glomerulonephritis with recurrence. (12162274)
2002
36
The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. (11709168)
2001
37
Cystic fibrosis mutation testing in Italy. (11788089)
2001
38
15-LOX-1: a novel molecular target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells. (10904086)
2000
39
Combinatorial effect of T-cell receptor ligation and CD45 isoform expression on the signaling contribution of the small GTPases Ras and Rap1. (11073975)
2000
40
A Laugier-Hunziker syndrome associated with esophageal melanocytosis. (10559586)
1999
41
Importance of serum CA 125 levels in malignant peritoneal mesothelioma. (7501967)
1996
42
Immunocytochemical and morphometric study on the changes of TSH, PRL, GH and ACTH cells during the development of Bufo arenarum. (8581952)
1996
43
Basic amino acid residue cluster within nuclear targeting sequence motif is essential for cytoplasmic plectin-vimentin network junctions. (8830774)
1996
44
Balint's syndrome arising from bilateral posterior cortical atrophy or infarction: rehabilitation strategies and their limitation. (8783001)
1996
45
Mapping of a human brain voltage-gated calcium channel to human chromosome 12p13-pter. (1335957)
1992
46
Evidence for involvement of endogenous somatostatin in the galanin-induced growth hormone secretion in children. (1692988)
1990
47
A consideration in evaluation of short stature. Cohen syndrome. (2879822)
1987
48
Molecular characterization of the human excision repair gene ERCC-1: cDNA cloning and amino acid homology with the yeast DNA repair gene RAD10. (2420469)
1986
49
Case of Amyotonia Congenita. (19979758)
1917
50

Variations for Astroblastoma

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Expression for genes affiliated with Astroblastoma

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Search GEO for disease gene expression data for Astroblastoma.

Pathways for genes affiliated with Astroblastoma

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GO Terms for genes affiliated with Astroblastoma

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Cellular components related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament cytoskeletonGO:004511110.1NES, VIM

Biological processes related to Astroblastoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1intermediate filament-based processGO:004510310.1GFAP, VIM
22-oxoglutarate metabolic processGO:00061039.6IDH1, TAT

Sources for Astroblastoma

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet