MCID: AST007
MIFTS: 74

Astrocytoma malady

Cancer diseases, Neuronal diseases categories
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Summaries for Astrocytoma

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Disease Ontology:8 A malignant glioma that is has material basis in astocyte cells, a type of star-shaped glial cell, located in the cerebrum.

MalaCards based summary: Astrocytoma, also known as astrocytoma of cerebrum, is related to subependymal giant cell astrocytoma and juvenile pilocytic astrocytoma. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Inhibition of Ribosome Biogenesis by p14(ARF). The drugs cisplatin and temozolomide and the compounds reticulin and bcnu have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and spinal cord, and related mouse phenotypes are pigmentation and normal.

Wikipedia:65 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Aliases & Classifications for Astrocytoma

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Sources:
8Disease Ontology, 44Novoseek, 62UMLS, 57SNOMED-CT, 39NCIt, 34MeSH
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Astrocytoma, Aliases & Descriptions:

Name: Astrocytoma 8 44 62
Astrocytoma of Cerebrum 8 62
Astrocytoma of Brain 8 62
Cerebral Astrocytoma 8 62
 
Astrocytic Tumor 8 62
Astrocytoma, No Icd-O Subtype 8
Astroglioma 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology8 DOID:3069
MeSH34 D001254

Related Diseases for Astrocytoma

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Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 310)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma32.1S100B, SYP
2juvenile pilocytic astrocytoma31.9TNC
3tuberous sclerosis31.6S100B, SYP, NES, PTEN, GFAP
4gemistocytic astrocytoma31.4S100B, PTEN, GFAP
5neuroblastoma31.3SYP, TP53
6oligoastrocytoma31.3GFAP, MGMT
7ganglioglioma31.1S100B, SYP, GFAP
8pilocytic astrocytoma31.0CDK4, S100B, OLIG2, SYP, LGALS3, NES
9turcot syndrome31.0PTEN
10dysembryoplastic neuroepithelial tumor30.9KIAA1549, OLIG2, SYP
11meningioma30.9S100B, PCNA, SYP, TP73, PTEN, TNC
12gliosarcoma30.8CDK4, PTEN, GFAP
13medulloblastoma30.8CDK4, S100B, SYP, NES, TP73, TP53
14ependymoma30.8EGFR, S100B, SYP, NES, TP73, GFAP
15glioblastoma multiforme30.7EGFR, CDK4, CDKN2A, NES, TP53, PTEN
16gangliocytoma30.7SYP, PTEN
17giant cell glioblastoma30.7EGFR, PTEN, GFAP
18gliomatosis cerebri30.6PTEN, GFAP
19central neurocytoma30.6OLIG2, SYP, GFAP
20myxopapillary ependymoma30.5S100B, GFAP
21pineoblastoma30.5SYP, GFAP
22hemangioblastoma30.5S100B, SYP, NES, GFAP
23choroid plexus carcinoma30.5S100B, GFAP
24li-fraumeni syndrome30.5CDKN2A, TP53
25brain cancer30.4EGFR, MGMT
26chordoma30.4S100B, LGALS3, GFAP
27neurilemmoma30.4S100B, NES, GFAP
28acute lymphoblastic leukemia30.3CDK4, CDKN2A, TP73, IGFBP2
29xeroderma pigmentosum30.3PCNA, TP53, MGMT
30pleomorphic adenoma30.3S100B, PCNA, TNC, GFAP
31neurofibroma30.3S100B, SYP, TP73, TNC
32b-cell lymphomas30.2CDK4, CDKN2A, TP53, MGMT
33breast cancer30.1EGFR, CDK4, TNC
34papilloma30.1CDKN2A, PCNA, TP73, TP53
35anaplastic oligodendroglioma30.1EGFR, CDK4, CDKN2A, OLIG2, LGALS3, PTEN
36osteosarcoma30.1CDK4, CDKN2A, TP73, TP53
37retinoblastoma30.0EGFR, CDK4, CDKN2A, PCNA, SYP, TP73
38glioblastoma30.0EGFR, CDK4, CDKN2A, S100B, OLIG2, PCNA
39pituitary adenoma30.0CDK4, PCNA, SYP, LGALS3, NES, TP73
40leukemia29.9CDK4, CDKN2A, OLIG2, NES, TP73, TP53
41oligodendroglioma29.9EGFR, CDK4, CDKN2A, OLIG2, PCNA, SYP
42grade iii astrocytoma29.9EGFR, CDK4, CDKN2A, OLIG2, PCNA, LGALS3
43adenoma29.7CDK4, CDKN2A, PCNA, SYP, LGALS3, NES
44malignant glioma29.5EGFR, CDK4, CDKN2A, KIAA1549, OLIG2, PCNA
45prostate cancer29.5EGFR, CDK4, PCNA, LGALS3, NES, TP73
46colorectal cancer29.5EGFR, CDKN2A, PCNA, LGALS3, TP73, TP53
47melanoma29.4CDK4, CDKN2A, S100B, PCNA, LGALS3, NES
48adenocarcinoma29.3EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
49cerebellar astrocytoma10.8
50pilomyxoid astrocytoma10.7

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Symptoms for Astrocytoma

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Drugs & Therapeutics for Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Inferred drug relations via UMLS62/NDF-RT40:

Genetic Tests for Astrocytoma

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Anatomical Context for Astrocytoma

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MalaCards organs/tissues related to Astrocytoma:

32
Brain, Spinal cord, Endothelial, Cerebellum, Pineal, Pituitary, Cortex, Temporal lobe, Thyroid, Breast, Colon, Ovary, Testes, Monocytes, Eye, Bone, Retina, Lung, Testis, T cells, Hypothalamus, Tongue, Bone marrow, Liver, Skin, Prostate, Myeloid, B cells, Prefrontal cortex, Medulla oblongata

FMA organs/tissues related to Astrocytoma:

14
The cerebrum

Animal Models for Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Astrocytoma:

36 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7EGFR, CDKN2A, TP53, PTEN
2MP:00028739.2IGFBP2, GFAP, TNC, PTEN, TP53, SYP
3MP:00107719.2PTEN, TP53, LGALS3, S100B, CDKN2A, CDK4
4MP:00053699.2GFAP, PTEN, TP53, OLIG2, CDKN2A, CDK4
5MP:00053819.2GFAP, PTEN, TP53, TP73, LGALS3, CDKN2A
6MP:00053709.2IGFBP2, PTEN, TP53, CDKN2A, CDK4, EGFR
7MP:00053889.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
8MP:00020069.1MGMT, PTEN, TP53, TP73, OLIG2, CDKN2A
9MP:00053679.1IGFBP2, PTEN, TP53, LGALS3, CDK4, EGFR
10MP:00053809.1PTEN, TP53, TP73, NES, CDKN2A, CDK4
11MP:00053919.1GFAP, PTEN, TP53, TP73, OLIG2, CDKN2A
12MP:00030129.1MGMT, TP53, SYP, PCNA, NRN1, OLIG2
13MP:00053909.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
14MP:00053799.1MGMT, PTEN, TP53, TP73, PCNA, CDKN2A
15MP:00053859.0IGFBP2, GFAP, PTEN, TP53, TP73, LGALS3
16MP:00053759.0PTEN, TP53, PCNA, OLIG2, EGFR
17MP:00053899.0PTEN, TP53, TP73, LGALS3, PCNA, CDKN2A
18MP:00053868.7GFAP, TNC, PTEN, TP53, TP73, NES
19MP:00053768.6TNC, GFAP, IDH1, MGMT, PTEN, TP53
20MP:00053848.6TP73, TP53, PTEN, GFAP, NES, LGALS3
21MP:00053978.5IGFBP2, IDH1, PTEN, TP53, TP73, LGALS3
22MP:00053788.4GFAP, PTEN, TP53, TP73, NES, PCNA
23MP:00053878.4PTEN, GFAP, IDH1, IGFBP2, TP53, TP73
24MP:00036318.2EGFR, GFAP, TNC, PTEN, TP53, TP73
25MP:00107688.2TP73, TP53, PTEN, GFAP, MGMT, NES

Publications for Astrocytoma

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Articles related to Astrocytoma:

(show top 50)    (show all 1934)
idTitleAuthorsYear
1
Expression and functional significance of ezrin in human brain astrocytoma. (23712870)
2013
2
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
3
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
4
Expression and biological role of CIP2A in human astrocytoma. (23467938)
2013
5
Correlation of aquaporin-1 water channel protein expression with tumor angiogenesis in human astrocytoma. (23393355)
2013
6
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
7
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
8
Expression of pERK and pAKT in pediatric high grade astrocytomas: correlation with YKL40 and prognostic significance. (21978279)
2012
9
I^-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas. (22505738)
2012
10
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
11
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. (22347337)
2011
12
Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT. (20569675)
2010
13
Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. (19357230)
2009
14
Analysis of interleukin (IL)-8 expression in human astrocytomas: associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. (19332096)
2009
15
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
16
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas. (18713462)
2008
17
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
18
Congenital diffuse anaplastic astrocytoma with ependymal and leptomeningeal spread: case report. (17443288)
2007
19
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis. (17634619)
2007
20
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. (16298472)
2006
21
Immunohistochemical detection of epidermal growth factor receptor in human high-grade astrocytomas--a comparison between frozen- and paraffin sections. (15943037)
2005
22
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas. (15523899)
2004
23
Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. (15255942)
2004
24
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (15367334)
2004
25
Epigenetics in high-grade astrocytomas: opportunities for prevention and detection of brain tumors. (12724228)
2003
26
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (14581362)
2003
27
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. (12747804)
2003
28
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. (12866026)
2003
29
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
30
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
31
Expression and regulation of neuropilin-1 in human astrocytomas. (11058875)
2000
32
Spinal cord astrocytoma: response to PCV chemotherapy. (10668731)
2000
33
Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. (10554042)
1999
34
Astrocytoma cell interaction with elastin substrates: implications for astrocytoma invasive potential. (9890632)
1999
35
Glial fibrillary acidic protein and its fragments discriminate astrocytoma from oligodendroglioma. (10344289)
1999
36
Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma? (10630353)
1999
37
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
38
A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade. (9739111)
1998
39
The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells. (9821106)
1998
40
Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis. (9568761)
1998
41
Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment. (9293896)
1997
42
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
43
Immunohistochemical characterization of subependymal giant cell astrocytomas. (8928613)
1996
44
Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. (8290551)
1994
45
Simultaneous quantitation of cytokine mRNAs in interleukin-1 beta stimulated U373 human astrocytoma cells by a polymerisation chain reaction method involving co-amplification with an internal multi-specific control. (1296803)
1992
46
Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells. (1902475)
1991
47
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
48
Intracranial metastasis of a spinal cord astrocytoma--case report. (1694278)
1990
49
Multiple primary intracranial tumors of different cell types: association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature. (7179095)
1982
50
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Astrocytoma

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Expression for genes affiliated with Astrocytoma

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Expression patterns in normal tissues for genes affiliated with Astrocytoma

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Pathways for genes affiliated with Astrocytoma

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Pathways related to Astrocytoma according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1LGALS3, S100B
210.1CDKN2A, TP53
39.9CDK4, TP53, MGMT
49.9CDK4, TP53, PTEN
5
Show member pathways
9.9CDK4, TP53, PTEN
6
Show member pathways
Prostate Cancer37
Integrated Cancer pathway37
Steroid Biosynthesis37
9.9CDK4, TP53, PTEN
79.9TP53, TP73, CDK4
8
Show member pathways
9.9TP53, CDKN2A, CDK4
99.9CDK4, CDKN2A, TP53
109.9CDK4, CDKN2A, TP53
11
Show member pathways
9.8TP53, TP73, CDKN2A
12
Show member pathways
Apoptosis Modulation and Signaling37
Apoptosis37
9.8TP53, TP73, CDKN2A
139.8GFAP, TNC, SYP, S100B
149.8CDK4, PCNA, TP53
15
Show member pathways
9.8CDK4, PCNA, TP53
169.8CDK4, PCNA, TP53
179.8TP53, PCNA, CDK4
18
Show member pathways
9.8GFAP, PTEN, S100B, EGFR
19
Show member pathways
9.8EGFR, TP53, PTEN, TNC
209.7PTEN, TP53, CDK4, EGFR
219.7EGFR, CDK4, TP53, PTEN
22
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor37
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.7PTEN, TP53, TP73, EGFR
23
Show member pathways
9.7EGFR, CDK4, CDKN2A, TP53
24
Show member pathways
DNA damage response (only ATM dependent)37
Wnt Signaling Pathway and Pluripotency37
9.7CDKN2A, TP73, TP53, PTEN
25
Show member pathways
Toll-like receptor signaling pathway37
Regulation of toll-like receptor signaling pathway37
9.6PTEN, TP53, PCNA, CDK4
26
Show member pathways
Signal transduction PTEN pathway60
9.6PTEN, TP53, PCNA, EGFR
279.6PTEN, TP53, PCNA, CDKN2A
289.6TNC, PTEN, TP53, CDK4, EGFR
299.6CDK4, CDKN2A, PCNA, TP53
30
Show member pathways
9.6TP53, PCNA, CDKN2A, CDK4
31
Show member pathways
Cell cycle37
9.6TP53, PCNA, CDKN2A, CDK4
32
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.5IGFBP2, PTEN, TP53, PCNA
339.5GFAP, TP53, LGALS3, CDK4, EGFR
349.5EGFR, CDKN2A, TP53, PTEN, TNC
359.5PTEN, TP53, CDKN2A, CDK4, EGFR
36
Show member pathways
Signaling Pathways in Glioblastoma37
9.5PTEN, TP53, CDKN2A, CDK4, EGFR
37
Show member pathways
DNA damage response37
9.5PTEN, TP53, TP73, CDKN2A, CDK4
389.4PTEN, TP53, PCNA, CDK4, EGFR
399.4EGFR, PCNA, TP73, TP53, PTEN
409.3EGFR, CDK4, CDKN2A, TP53, PTEN, MGMT
41
Show member pathways
9.2GFAP, TNC, PTEN, TP53, CDKN2A, CDK4
42
Show member pathways
9.2MGMT, TP53, TP73, PCNA, CDKN2A, CDK4

Compounds for genes affiliated with Astrocytoma

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Compounds related to Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1reticulin4410.0GFAP, S100B, PCNA, SYP
2bcnu4410.0EGFR, MGMT, CDKN2A, TP53, GFAP
3olomoucine44 1110.9CDK4, CDKN2A, PCNA, TP53
4dutp449.8PCNA, SYP, LGALS3, TP53, GFAP
5crcs449.8MGMT, TP53, CDKN2A, PTEN
6o6-methylguanine449.8CDKN2A, MGMT, PCNA, TP73, TP53
7silver449.7CDKN2A, PCNA, SYP, TNC, GFAP
8deoxyribonucleic acid449.7MGMT, IGFBP2, PTEN, PCNA, CDKN2A
9gemcitabine44 50 1111.6TP53, PCNA, EGFR, TP73, PTEN
10vincristine44 50 1111.6TP53, TP73, MGMT, CDKN2A, PTEN
11temozolomide44 1110.6NES, TP53, EGFR, CDKN2A, PCNA, MGMT
12thymidylate449.6CDK4, CDKN2A, TP53, MGMT, EGFR, PCNA
13agar449.6CDK4, EGFR, CDKN2A, LGALS3, PTEN, GFAP
14egcg449.6CDKN2A, EGFR, TP53, PCNA, CDK4, MGMT
15bromodeoxyuridine449.5GFAP, CDK4, S100B, PCNA, NES, IGFBP2
16camptothecin44 61 1111.5CDKN2A, PCNA, TP53, TP73, MGMT, CDK4
175-aza-2deoxycytidine449.5PTEN, CDKN2A, TP53, TP73, MGMT, PCNA
18etoposide44 50 61 1112.5TP53, SYP, PTEN, PCNA, S100B, LGALS3
19hematoxylin449.5CDKN2A, GFAP, PCNA, PTEN, S100B, LGALS3
20glycogen44 2410.4IGFBP2, GFAP, PTEN, LGALS3, SYP, CDK4
21doxorubicin44 50 1111.4EGFR, TP53, TP73, CDKN2A, CDK4, PTEN
22thymidine44 2410.3GFAP, IGFBP2, S100B, MGMT, PCNA, TP53
23butyrate449.3PCNA, GFAP, CDKN2A, TP53, LGALS3, CDK4
24leucine449.3CDK4, CDKN2A, IGFBP2, GFAP, PTEN, S100B
25formaldehyde44 2410.3MGMT, PCNA, SYP, S100B, TNC, GFAP
26ly294002449.3EGFR, CDK4, TP53, PTEN, IGFBP2, TNC
27genistein44 28 61 2 24 1114.3CDK4, CDKN2A, PCNA, SYP, PTEN, GFAP
28cycloheximide449.3IGFBP2, TNC, CDKN2A, PTEN, EGFR, GFAP
295fluorouracil449.2PTEN, EGFR, CDKN2A, MGMT, PCNA, TP73
30nitric oxide44 24 1111.2CDKN2A, LGALS3, MGMT, CDK4, SYP, NES
31paclitaxel44 50 1111.1PCNA, S100B, CDKN2A, MGMT, CDK4, GFAP
32mg 13244 6110.1PCNA, CDKN2A, EGFR, TP53, PTEN
33dexamethasone44 50 28 1112.0MGMT, TNC, GFAP, PCNA, S100B, CDKN2A
34glutamate449.0LGALS3, PCNA, IDH1, GFAP, TNC, NES
35testosterone44 61 24 1112.0EGFR, IGFBP2, PCNA, GFAP, SYP, S100B
36cysteine448.9GFAP, MGMT, PTEN, LGALS3, CDK4, CDKN2A
37h2o2448.9TNC, PTEN, TP53, LGALS3, SYP, CDKN2A
38oxygen44 249.8CDKN2A, CDK4, IGFBP2, GFAP, PTEN, NES
39lipid448.8TNC, PTEN, TP73, GFAP, IGFBP2, S100B
40arginine448.8TP73, GFAP, PTEN, PCNA, CDK4, CDKN2A
41oligonucleotide448.7MGMT, IGFBP2, PTEN, TP53, TNC, CDK4
42serine448.7S100B, CDKN2A, EGFR, SYP, TNC, IGFBP2
43cisplatin44 50 61 1111.7EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
44tyrosine448.7IGFBP2, GFAP, EGFR, CDK4, S100B, SYP
45calcium44 50 24 1111.5IDH1, GFAP, IGFBP2, LGALS3, MGMT, TNC
46paraffin448.1CDK4, EGFR, CDKN2A, S100B, PCNA, MGMT
47progesterone44 28 61 24 1111.9IGFBP2, PTEN, TP53, TP73, NES, LGALS3
48vegf447.9EGFR, LGALS3, MGMT, IGFBP2, GFAP, TNC
49estrogen447.9IGFBP2, EGFR, CDK4, PCNA, S100B, CDKN2A
50retinoic acid44 248.5TNC, GFAP, IGFBP2, MGMT, PTEN, TP53

GO Terms for genes affiliated with Astrocytoma

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Cellular components related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.9CDK4, TP73, TP53
2cytoplasmGO:0057377.7TRIM47, IDH1, GFAP, PTEN, TP53, NES
3nucleusGO:0056347.5LGALS3, TP73, TP53, PTEN, MGMT, PCNA

Biological processes related to Astrocytoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell sizeGO:04579310.3CDK4, TP73
2long-term synaptic potentiationGO:06029110.3S100B, PTEN, GFAP
3regulation of neuronal synaptic plasticityGO:04816810.3S100B, SYP
4mitotic G1 DNA damage checkpointGO:03157110.3TP73, TP53
5replicative senescenceGO:09039910.3CDKN2A, TP53
6learning or memoryGO:00761110.3EGFR, S100B, PTEN
7response to ethanolGO:04547110.3PTEN, TNC, MGMT
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP73, TP53
9digestive tract morphogenesisGO:04854610.2EGFR, TP73
10positive regulation of oligodendrocyte differentiationGO:04871410.1TP73, OLIG2
11central nervous system developmentGO:00741710.1S100B, NES, TP53, PTEN
12positive regulation of cell cycle arrestGO:07115810.1CDKN2A, TP53
13response to X-rayGO:01016510.0TP53, TP73
14mismatch repairGO:0062989.9PCNA, TP73
15cell cycle arrestGO:0070509.9TP53, TP73, CDKN2A
16response to drugGO:0424939.9MGMT, IGFBP2, PTEN, CDK4
17positive regulation of cell proliferationGO:0082849.9TNC, PTEN, S100B, CDK4, EGFR
18positive regulation of apoptotic processGO:0430659.9PTEN, TP53, TP73, S100B, CDK4
19phosphatidylinositol-mediated signalingGO:0480159.9EGFR, PCNA, PTEN
20cell proliferationGO:0082839.8PTEN, TP53, PCNA, S100B, EGFR
21G1/S transition of mitotic cell cycleGO:0000829.4CDK4, CDKN2A, PCNA

Molecular functions related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:09737110.1CDKN2A, TP53
2p53 bindingGO:0020399.5CDKN2A, TP73, TP53
3protein kinase bindingGO:0199019.4PTEN, TP53, TP73, CDKN2A, EGFR
4identical protein bindingGO:0428029.2EGFR, S100B, PCNA, SYP, TP73, TP53

Products for genes affiliated with Astrocytoma

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  • Antibodies
  • Proteins
  • Lysates

Sources for Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet