MCID: AST007
MIFTS: 72

Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Astrocytoma

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Disease Ontology:10 A malignant glioma that is has material basis in astocyte cells, a type of star-shaped glial cell, located in the cerebrum.

MalaCards based summary: Astrocytoma, also known as astrocytoma of cerebrum, is related to pilocytic astrocytoma and subependymal giant cell astrocytoma. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Inhibition of Ribosome Biogenesis by p14(ARF). The drugs cisplatin and temozolomide and the compounds reticulin and bcnu have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and spinal cord, and related mouse phenotypes are pigmentation and normal.

Wikipedia:65 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Aliases & Classifications for Astrocytoma

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Sources:
10Disease Ontology, 45Novoseek, 62UMLS, 40NCIt, 57SNOMED-CT, 35MeSH
See all sources

Astrocytoma, Aliases & Descriptions:

Name: Astrocytoma 10 45 62
Astrocytoma of Cerebrum 10 62
Astrocytoma of Brain 10 62
Cerebral Astrocytoma 10 62
 
Astrocytic Tumor 10 62
Astrocytoma, No Icd-O Subtype 10
Astroglioma 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology10 DOID:3069
MeSH35 D001254

Related Diseases for Astrocytoma

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Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1pilocytic astrocytoma31.6CDK4, S100B, OLIG2, SYP, LGALS3, NES
2subependymal giant cell astrocytoma31.4S100B, SYP
3tuberous sclerosis31.2S100B, SYP, NES, PTEN, GFAP
4juvenile pilocytic astrocytoma31.1TNC
5glioblastoma31.1EGFR, CDK4, CDKN2A, S100B, OLIG2, PCNA
6glioblastoma multiforme30.9EGFR, CDK4, CDKN2A, NES, TP53, PTEN
7gemistocytic astrocytoma30.8S100B, PTEN, GFAP
8oligodendroglioma30.8EGFR, CDK4, CDKN2A, OLIG2, PCNA, SYP
9medulloblastoma30.8CDK4, S100B, SYP, NES, TP73, TP53
10grade iii astrocytoma30.7EGFR, CDK4, CDKN2A, OLIG2, PCNA, LGALS3
11neuroblastoma30.7SYP, TP53
12ependymoma30.6EGFR, S100B, SYP, NES, TP73, GFAP
13oligoastrocytoma30.6GFAP, MGMT
14ganglioglioma30.5S100B, SYP, GFAP
15dysembryoplastic neuroepithelial tumor30.3KIAA1549, OLIG2, SYP
16anaplastic oligodendroglioma30.3EGFR, CDK4, CDKN2A, OLIG2, LGALS3, PTEN
17malignant glioma30.3EGFR, CDK4, CDKN2A, KIAA1549, OLIG2, PCNA
18retinoblastoma30.2EGFR, CDK4, CDKN2A, PCNA, SYP, TP73
19leukemia30.2CDK4, CDKN2A, OLIG2, NES, TP73, TP53
20gliosarcoma30.2CDK4, PTEN, GFAP
21adenoma30.1CDK4, CDKN2A, PCNA, SYP, LGALS3, NES
22gangliocytoma30.1SYP, PTEN
23renal cell carcinoma30.1EGFR, TP53
24giant cell glioblastoma30.1EGFR, PTEN, GFAP
25central neurocytoma30.0OLIG2, SYP, GFAP
26hemangioblastoma30.0S100B, SYP, NES, GFAP
27adenocarcinoma30.0EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
28pituitary adenoma30.0CDK4, PCNA, SYP, LGALS3, NES, TP73
29melanoma29.9CDK4, CDKN2A, S100B, PCNA, LGALS3, NES
30gliomatosis cerebri29.9PTEN, GFAP
31myxopapillary ependymoma29.8S100B, GFAP
32pineoblastoma29.8SYP, GFAP
33choroid plexus carcinoma29.8S100B, GFAP
34li-fraumeni syndrome29.8CDKN2A, TP53
35brain cancer29.8EGFR, MGMT
36chordoma29.8S100B, LGALS3, GFAP
37neurilemmoma29.8S100B, NES, GFAP
38mesothelioma29.8CDK4, CDKN2A, TNC
39pleomorphic adenoma29.8S100B, PCNA, TNC, GFAP
40neurofibroma29.8S100B, SYP, TP73, TNC
41b-cell lymphomas29.8CDK4, CDKN2A, TP53, MGMT
42papilloma29.8CDKN2A, PCNA, TP73, TP53
43breast cancer29.8PCNA, TP53
44colorectal cancer29.8EGFR, CDK4, LGALS3, TP73, TP53, IGFBP2
45prostate cancer29.7EGFR, CDK4, PCNA, LGALS3, NES, TP73
46cerebellar astrocytoma10.8
47pilomyxoid astrocytoma10.7
48spinal cord astrocytoma10.7
49fibrillary astrocytoma10.6
50endotheliitis10.5

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Symptoms for Astrocytoma

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Drugs & Therapeutics for Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Inferred drug relations via UMLS62/NDF-RT41:

Genetic Tests for Astrocytoma

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Anatomical Context for Astrocytoma

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MalaCards organs/tissues related to Astrocytoma:

33
Brain, Spinal cord, Endothelial, Cerebellum, Pineal, Pituitary, Cortex, Temporal lobe, Thyroid, Breast, Colon, Ovary, Testes, Monocytes, Eye, Bone, Retina, Lung, Testis, T cells, Hypothalamus, Medulla oblongata, Tongue, Bone marrow, Liver, Skin, Prostate, Myeloid, B cells, Prefrontal cortex

FMA organs/tissues related to Astrocytoma:

16
The cerebrum

Animal Models for Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Astrocytoma:

37 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7EGFR, CDKN2A, TP53, PTEN
2MP:00028739.2IGFBP2, GFAP, TNC, PTEN, TP53, SYP
3MP:00107719.2PTEN, TP53, LGALS3, S100B, CDKN2A, CDK4
4MP:00053699.2GFAP, PTEN, TP53, OLIG2, CDKN2A, CDK4
5MP:00053819.2GFAP, PTEN, TP53, TP73, LGALS3, CDKN2A
6MP:00053709.2IGFBP2, PTEN, TP53, CDKN2A, CDK4, EGFR
7MP:00053889.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
8MP:00020069.1MGMT, PTEN, TP53, TP73, OLIG2, CDKN2A
9MP:00053679.1IGFBP2, PTEN, TP53, LGALS3, CDK4, EGFR
10MP:00053809.1PTEN, TP53, TP73, NES, CDKN2A, CDK4
11MP:00053919.1GFAP, PTEN, TP53, TP73, OLIG2, CDKN2A
12MP:00030129.1MGMT, TP53, SYP, PCNA, NRN1, OLIG2
13MP:00053909.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
14MP:00053799.1MGMT, PTEN, TP53, TP73, PCNA, CDKN2A
15MP:00053859.0IGFBP2, GFAP, PTEN, TP53, TP73, LGALS3
16MP:00053759.0PTEN, TP53, PCNA, OLIG2, EGFR
17MP:00053899.0PTEN, TP53, TP73, LGALS3, PCNA, CDKN2A
18MP:00053868.7GFAP, TNC, PTEN, TP53, TP73, NES
19MP:00053768.6TNC, GFAP, IDH1, MGMT, PTEN, TP53
20MP:00053848.6TP73, TP53, PTEN, GFAP, NES, LGALS3
21MP:00053978.5IGFBP2, IDH1, PTEN, TP53, TP73, LGALS3
22MP:00053788.4GFAP, PTEN, TP53, TP73, NES, PCNA
23MP:00053878.4PTEN, GFAP, IDH1, IGFBP2, TP53, TP73
24MP:00036318.2EGFR, GFAP, TNC, PTEN, TP53, TP73
25MP:00107688.2TP73, TP53, PTEN, GFAP, MGMT, NES

Publications for Astrocytoma

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Articles related to Astrocytoma:

(show top 50)    (show all 1966)
idTitleAuthorsYear
1
Long survival in a child with a mutated K27M-H3.3 pilocytic astrocytoma. (25909089)
2015
2
Expression and functional significance of ezrin in human brain astrocytoma. (23712870)
2013
3
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
4
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
5
Expression and biological role of CIP2A in human astrocytoma. (23467938)
2013
6
Correlation of aquaporin-1 water channel protein expression with tumor angiogenesis in human astrocytoma. (23393355)
2013
7
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
8
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
9
Expression of pERK and pAKT in pediatric high grade astrocytomas: correlation with YKL40 and prognostic significance. (21978279)
2012
10
I^-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas. (22505738)
2012
11
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
12
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. (22347337)
2011
13
Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT. (20569675)
2010
14
Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. (19357230)
2009
15
Analysis of interleukin (IL)-8 expression in human astrocytomas: associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. (19332096)
2009
16
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
17
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas. (18713462)
2008
18
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
19
Congenital diffuse anaplastic astrocytoma with ependymal and leptomeningeal spread: case report. (17443288)
2007
20
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis. (17634619)
2007
21
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. (16298472)
2006
22
Immunohistochemical detection of epidermal growth factor receptor in human high-grade astrocytomas--a comparison between frozen- and paraffin sections. (15943037)
2005
23
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas. (15523899)
2004
24
Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. (15255942)
2004
25
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (15367334)
2004
26
Epigenetics in high-grade astrocytomas: opportunities for prevention and detection of brain tumors. (12724228)
2003
27
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (14581362)
2003
28
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. (12747804)
2003
29
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. (12866026)
2003
30
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
31
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
32
Expression and regulation of neuropilin-1 in human astrocytomas. (11058875)
2000
33
Spinal cord astrocytoma: response to PCV chemotherapy. (10668731)
2000
34
Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. (10554042)
1999
35
Astrocytoma cell interaction with elastin substrates: implications for astrocytoma invasive potential. (9890632)
1999
36
Glial fibrillary acidic protein and its fragments discriminate astrocytoma from oligodendroglioma. (10344289)
1999
37
Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma? (10630353)
1999
38
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
39
A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade. (9739111)
1998
40
The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells. (9821106)
1998
41
Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis. (9568761)
1998
42
Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment. (9293896)
1997
43
Immunohistochemical characterization of subependymal giant cell astrocytomas. (8928613)
1996
44
Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. (8290551)
1994
45
Simultaneous quantitation of cytokine mRNAs in interleukin-1 beta stimulated U373 human astrocytoma cells by a polymerisation chain reaction method involving co-amplification with an internal multi-specific control. (1296803)
1992
46
Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells. (1902475)
1991
47
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
48
Intracranial metastasis of a spinal cord astrocytoma--case report. (1694278)
1990
49
Multiple primary intracranial tumors of different cell types: association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature. (7179095)
1982
50
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Astrocytoma

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Cosmic variations for Astrocytoma:

8
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144653TP53central nervous system,spinal cord,glioma,astrocytoma Grade IV3

Expression for genes affiliated with Astrocytoma

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Search GEO for disease gene expression data for Astrocytoma.

Pathways for genes affiliated with Astrocytoma

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Pathways related to Astrocytoma according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1LGALS3, S100B
210.1CDKN2A, TP53
39.9CDK4, TP53, MGMT
49.9CDK4, TP53, PTEN
5
Show member pathways
9.9CDK4, TP53, PTEN
6
Show member pathways
Prostate Cancer38
Integrated Cancer pathway38
Steroid Biosynthesis38
9.9CDK4, TP53, PTEN
79.9TP53, TP73, CDK4
8
Show member pathways
9.9TP53, CDKN2A, CDK4
99.9CDK4, CDKN2A, TP53
109.9CDK4, CDKN2A, TP53
11
Show member pathways
9.8TP53, TP73, CDKN2A
12
Show member pathways
Apoptosis Modulation and Signaling38
Apoptosis38
9.8TP53, TP73, CDKN2A
139.8GFAP, TNC, SYP, S100B
149.8CDK4, PCNA, TP53
15
Show member pathways
9.8CDK4, PCNA, TP53
169.8CDK4, PCNA, TP53
179.8TP53, PCNA, CDK4
18
Show member pathways
9.8GFAP, PTEN, S100B, EGFR
19
Show member pathways
9.8EGFR, TP53, PTEN, TNC
209.7PTEN, TP53, CDK4, EGFR
219.7EGFR, CDK4, TP53, PTEN
22
Show member pathways
Development EGFR signaling via PIP360
Development PDGF signaling via MAPK cascades60
Apoptosis and survival Anti apoptotic action of membrane bound ESR160
Signaling of Hepatocyte Growth Factor Receptor38
Development EGFR signaling via small GTPases60
Development Neurotrophin family signaling60
Apoptosis and survival NGF signaling pathway60
Apoptosis and survival Role of CDK5 in neuronal death and survival60
9.7PTEN, TP53, TP73, EGFR
23
Show member pathways
9.7EGFR, CDK4, CDKN2A, TP53
24
Show member pathways
DNA damage response (only ATM dependent)38
Wnt Signaling Pathway and Pluripotency38
9.7CDKN2A, TP73, TP53, PTEN
25
Show member pathways
Toll-like receptor signaling pathway38
Regulation of toll-like receptor signaling pathway38
9.6PTEN, TP53, PCNA, CDK4
26
Show member pathways
Signal transduction PTEN pathway60
9.6PTEN, TP53, PCNA, EGFR
279.6PTEN, TP53, PCNA, CDKN2A
289.6TNC, PTEN, TP53, CDK4, EGFR
299.6CDK4, CDKN2A, PCNA, TP53
30
Show member pathways
9.6TP53, PCNA, CDKN2A, CDK4
31
Show member pathways
Cell cycle38
9.6TP53, PCNA, CDKN2A, CDK4
32
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.5IGFBP2, PTEN, TP53, PCNA
339.5GFAP, TP53, LGALS3, CDK4, EGFR
349.5EGFR, CDKN2A, TP53, PTEN, TNC
359.5PTEN, TP53, CDKN2A, CDK4, EGFR
36
Show member pathways
Signaling Pathways in Glioblastoma38
9.5PTEN, TP53, CDKN2A, CDK4, EGFR
37
Show member pathways
DNA damage response38
9.5PTEN, TP53, TP73, CDKN2A, CDK4
389.4PTEN, TP53, PCNA, CDK4, EGFR
399.4EGFR, PCNA, TP73, TP53, PTEN
409.3EGFR, CDK4, CDKN2A, TP53, PTEN, MGMT
41
Show member pathways
9.2GFAP, TNC, PTEN, TP53, CDKN2A, CDK4
42
Show member pathways
9.2MGMT, TP53, TP73, PCNA, CDKN2A, CDK4

Compounds for genes affiliated with Astrocytoma

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Compounds related to Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1reticulin4510.0GFAP, S100B, PCNA, SYP
2bcnu4510.0EGFR, MGMT, CDKN2A, TP53, GFAP
3olomoucine45 1310.9CDK4, CDKN2A, PCNA, TP53
4dutp459.8PCNA, SYP, LGALS3, TP53, GFAP
5crcs459.8MGMT, TP53, CDKN2A, PTEN
6o6-methylguanine459.8CDKN2A, MGMT, PCNA, TP73, TP53
7silver459.7CDKN2A, PCNA, SYP, TNC, GFAP
8deoxyribonucleic acid459.7MGMT, IGFBP2, PTEN, PCNA, CDKN2A
9gemcitabine45 51 1311.6TP53, PCNA, EGFR, TP73, PTEN
10vincristine45 51 1311.6TP53, TP73, MGMT, CDKN2A, PTEN
11temozolomide45 1310.6NES, TP53, EGFR, CDKN2A, PCNA, MGMT
12thymidylate459.6CDK4, CDKN2A, TP53, MGMT, EGFR, PCNA
13agar459.6CDK4, EGFR, CDKN2A, LGALS3, PTEN, GFAP
14egcg459.6CDKN2A, EGFR, TP53, PCNA, CDK4, MGMT
15bromodeoxyuridine459.5GFAP, CDK4, S100B, PCNA, NES, IGFBP2
16camptothecin45 61 1311.5CDKN2A, PCNA, TP53, TP73, MGMT, CDK4
175-aza-2deoxycytidine459.5PTEN, CDKN2A, TP53, TP73, MGMT, PCNA
18etoposide45 51 61 1312.5TP53, SYP, PTEN, PCNA, S100B, LGALS3
19hematoxylin459.5CDKN2A, GFAP, PCNA, PTEN, S100B, LGALS3
20glycogen45 2610.4IGFBP2, GFAP, PTEN, LGALS3, SYP, CDK4
21doxorubicin45 51 1311.4EGFR, TP53, TP73, CDKN2A, CDK4, PTEN
22thymidine45 2610.3GFAP, IGFBP2, S100B, MGMT, PCNA, TP53
23butyrate459.3PCNA, GFAP, CDKN2A, TP53, LGALS3, CDK4
24leucine459.3CDK4, CDKN2A, IGFBP2, GFAP, PTEN, S100B
25formaldehyde45 2610.3MGMT, PCNA, SYP, S100B, TNC, GFAP
26ly294002459.3EGFR, CDK4, TP53, PTEN, IGFBP2, TNC
27genistein45 30 61 3 26 1314.3CDK4, CDKN2A, PCNA, SYP, PTEN, GFAP
28cycloheximide459.3IGFBP2, TNC, CDKN2A, PTEN, EGFR, GFAP
295fluorouracil459.2PTEN, EGFR, CDKN2A, MGMT, PCNA, TP73
30nitric oxide45 26 1311.2CDKN2A, LGALS3, MGMT, CDK4, SYP, NES
31paclitaxel45 51 1311.1PCNA, S100B, CDKN2A, MGMT, CDK4, GFAP
32mg 13245 6110.1PCNA, CDKN2A, EGFR, TP53, PTEN
33dexamethasone45 51 30 1312.0MGMT, TNC, GFAP, PCNA, S100B, CDKN2A
34glutamate459.0LGALS3, PCNA, IDH1, GFAP, TNC, NES
35testosterone45 61 26 1312.0EGFR, IGFBP2, PCNA, GFAP, SYP, S100B
36cysteine458.9GFAP, MGMT, PTEN, LGALS3, CDK4, CDKN2A
37h2o2458.9TNC, PTEN, TP53, LGALS3, SYP, CDKN2A
38oxygen45 269.8CDKN2A, CDK4, IGFBP2, GFAP, PTEN, NES
39lipid458.8TNC, PTEN, TP73, GFAP, IGFBP2, S100B
40arginine458.8TP73, GFAP, PTEN, PCNA, CDK4, CDKN2A
41oligonucleotide458.7MGMT, IGFBP2, PTEN, TP53, TNC, CDK4
42serine458.7S100B, CDKN2A, EGFR, SYP, TNC, IGFBP2
43cisplatin45 51 61 1311.7EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
44tyrosine458.7IGFBP2, GFAP, EGFR, CDK4, S100B, SYP
45calcium45 51 26 1311.5IDH1, GFAP, IGFBP2, LGALS3, MGMT, TNC
46paraffin458.1CDK4, EGFR, CDKN2A, S100B, PCNA, MGMT
47progesterone45 30 61 26 1311.9IGFBP2, PTEN, TP53, TP73, NES, LGALS3
48vegf457.9EGFR, LGALS3, MGMT, IGFBP2, GFAP, TNC
49estrogen457.9IGFBP2, EGFR, CDK4, PCNA, S100B, CDKN2A
50retinoic acid45 268.5TNC, GFAP, IGFBP2, MGMT, PTEN, TP53

GO Terms for genes affiliated with Astrocytoma

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Cellular components related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00007859.9CDK4, TP73, TP53
2cytoplasmGO:00057377.7TRIM47, IDH1, GFAP, PTEN, TP53, NES
3nucleusGO:00056347.5LGALS3, TP73, TP53, PTEN, MGMT, PCNA

Biological processes related to Astrocytoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell sizeGO:004579310.3CDK4, TP73
2long-term synaptic potentiationGO:006029110.3S100B, PTEN, GFAP
3regulation of neuronal synaptic plasticityGO:004816810.3S100B, SYP
4mitotic G1 DNA damage checkpointGO:003157110.3TP73, TP53
5replicative senescenceGO:009039910.3CDKN2A, TP53
6learning or memoryGO:000761110.3EGFR, S100B, PTEN
7response to ethanolGO:004547110.3PTEN, TNC, MGMT
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.2TP73, TP53
9digestive tract morphogenesisGO:004854610.2EGFR, TP73
10positive regulation of oligodendrocyte differentiationGO:004871410.1TP73, OLIG2
11central nervous system developmentGO:000741710.1S100B, NES, TP53, PTEN
12positive regulation of cell cycle arrestGO:007115810.1CDKN2A, TP53
13response to X-rayGO:001016510.0TP53, TP73
14mismatch repairGO:00062989.9PCNA, TP73
15cell cycle arrestGO:00070509.9TP53, TP73, CDKN2A
16response to drugGO:00424939.9MGMT, IGFBP2, PTEN, CDK4
17positive regulation of cell proliferationGO:00082849.9TNC, PTEN, S100B, CDK4, EGFR
18positive regulation of apoptotic processGO:00430659.9PTEN, TP53, TP73, S100B, CDK4
19phosphatidylinositol-mediated signalingGO:00480159.9EGFR, PCNA, PTEN
20cell proliferationGO:00082839.8PTEN, TP53, PCNA, S100B, EGFR
21G1/S transition of mitotic cell cycleGO:00000829.4CDK4, CDKN2A, PCNA

Molecular functions related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:009737110.1CDKN2A, TP53
2p53 bindingGO:00020399.5CDKN2A, TP73, TP53
3protein kinase bindingGO:00199019.4PTEN, TP53, TP73, CDKN2A, EGFR
4identical protein bindingGO:00428029.2EGFR, S100B, PCNA, SYP, TP73, TP53

Products for genes affiliated with Astrocytoma

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  • Antibodies
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Sources for Astrocytoma

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet