MCID: AST007
MIFTS: 63

Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Aliases & Classifications for Astrocytoma

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Sources:
9Disease Ontology, 43Novoseek, 60UMLS, 38NCIt, 55SNOMED-CT, 33MeSH
See all sources

Astrocytoma, Aliases & Descriptions:

Name: Astrocytoma 9 43 60
Cerebral Astrocytoma 9 60
Astrocytoma, No Icd-O Subtype 9
Astrocytoma of Cerebrum 9
 
Astrocytoma of Brain 9
Astrocytic Tumor 9
Astroglioma 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


External Ids:

Disease Ontology9 DOID:3069
MeSH33 D001254

Summaries for Astrocytoma

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Disease Ontology:9 A malignant glioma that is has material basis in astocyte cells, a type of star-shaped glial cell, located in the cerebrum.

MalaCards based summary: Astrocytoma, also known as cerebral astrocytoma, is related to subependymal giant cell astrocytoma and juvenile pilocytic astrocytoma. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Inhibition of Ribosome Biogenesis by p14(ARF). The drugs cisplatin and cisplatin pwdr and the compounds reticulin and bcnu have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and spinal cord, and related mouse phenotypes are pigmentation and normal.

Wikipedia:63 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Related Diseases for Astrocytoma

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Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 303)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma32.1S100B, SYP
2juvenile pilocytic astrocytoma31.9TNC
3tuberous sclerosis31.6S100B, SYP, NES, PTEN, GFAP
4gemistocytic astrocytoma31.5S100B, PTEN, GFAP
5neuroblastoma31.3SYP, TP53
6oligoastrocytoma31.3GFAP, MGMT
7ganglioglioma31.1S100B, SYP, GFAP
8pilocytic astrocytoma31.0CDK4, S100B, OLIG2, SYP, LGALS3, NES
9oligodendroglioma31.0EGFR, CDKN2A, OLIG2, TP73, PTEN, GFAP
10dysembryoplastic neuroepithelial tumor30.9KIAA1549, OLIG2, SYP
11gliosarcoma30.8CDK4, PTEN, GFAP
12medulloblastoma30.8CDK4, S100B, SYP, NES, TP73, TP53
13ependymoma30.8EGFR, S100B, SYP, NES, TP73, GFAP
14glioblastoma multiforme30.7EGFR, CDK4, CDKN2A, NES, TP53, PTEN
15gangliocytoma30.7SYP, PTEN
16renal cell carcinoma30.7EGFR, TP53
17giant cell glioblastoma30.7EGFR, PTEN, GFAP
18gliomatosis cerebri30.6PTEN, GFAP
19central neurocytoma30.6OLIG2, SYP, GFAP
20myxopapillary ependymoma30.5S100B, GFAP
21pineoblastoma30.5SYP, GFAP
22hemangioblastoma30.5S100B, SYP, NES, GFAP
23choroid plexus carcinoma30.5S100B, GFAP
24li-fraumeni syndrome30.4CDKN2A, TP53
25brain cancer30.4EGFR, MGMT
26chordoma30.4S100B, LGALS3, GFAP
27neurilemmoma30.4S100B, NES, GFAP
28mesothelioma30.3CDK4, CDKN2A, TNC
29pleomorphic adenoma30.3S100B, PCNA, TNC, GFAP
30neurofibroma30.3S100B, SYP, TP73, TNC
31b-cell lymphomas30.2CDK4, CDKN2A, TP53, MGMT
32papilloma30.1CDKN2A, PCNA, TP73, TP53
33anaplastic oligodendroglioma30.1EGFR, CDK4, CDKN2A, OLIG2, LGALS3, PTEN
34retinoblastoma30.0EGFR, CDK4, CDKN2A, PCNA, SYP, TP73
35glioblastoma30.0EGFR, CDK4, CDKN2A, S100B, OLIG2, PCNA
36pituitary adenoma30.0CDK4, PCNA, SYP, LGALS3, NES, TP73
37breast cancer29.9PCNA, TP53
38leukemia29.9CDK4, CDKN2A, OLIG2, NES, TP73, TP53
39grade iii astrocytoma29.9EGFR, CDK4, CDKN2A, OLIG2, PCNA, LGALS3
40colorectal cancer29.8EGFR, CDK4, LGALS3, TP73, TP53, IGFBP2
41adenoma29.7CDK4, CDKN2A, PCNA, SYP, LGALS3, NES
42malignant glioma29.5EGFR, CDK4, CDKN2A, KIAA1549, OLIG2, PCNA
43prostate cancer29.5EGFR, CDK4, PCNA, LGALS3, NES, TP73
44melanoma29.3CDK4, CDKN2A, S100B, PCNA, LGALS3, NES
45adenocarcinoma29.3EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
46cerebellar astrocytoma10.8
47pilomyxoid astrocytoma10.7
48spinal cord astrocytoma10.7
49fibrillary astrocytoma10.6
50ependymoblastoma10.6GFAP

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Symptoms for Astrocytoma

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Drugs & Therapeutics for Astrocytoma

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Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Inferred drug relations via UMLS60/NDF-RT39:

Genetic Tests for Astrocytoma

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Anatomical Context for Astrocytoma

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MalaCards organs/tissues related to Astrocytoma:

31
Brain, Spinal cord, Endothelial, Cerebellum, Pineal, Pituitary, Cortex, Temporal lobe, Thyroid, Breast, Colon, Ovary, Testes, Monocytes, Eye, Bone, Retina, Lung, Testis, T cells, Hypothalamus, Medulla oblongata, Tongue, Bone marrow, Liver, Skin, Prostate, Myeloid, B cells, Prefrontal cortex

FMA organs/tissues related to Astrocytoma:

14
The cerebrum

Animal Models for Astrocytoma or affiliated genes

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MGI Mouse Phenotypes related to Astrocytoma:

35 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7EGFR, CDKN2A, TP53, PTEN
2MP:00028739.2IGFBP2, GFAP, TNC, PTEN, TP53, SYP
3MP:00107719.2PTEN, TP53, LGALS3, S100B, CDKN2A, CDK4
4MP:00053699.2GFAP, PTEN, TP53, OLIG2, CDKN2A, CDK4
5MP:00053819.2GFAP, PTEN, TP53, TP73, LGALS3, CDKN2A
6MP:00053709.2IGFBP2, PTEN, TP53, CDKN2A, CDK4, EGFR
7MP:00053889.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
8MP:00020069.1MGMT, PTEN, TP53, TP73, OLIG2, CDKN2A
9MP:00053679.1IGFBP2, PTEN, TP53, LGALS3, CDK4, EGFR
10MP:00053809.1PTEN, TP53, TP73, NES, CDKN2A, CDK4
11MP:00053919.1GFAP, PTEN, TP53, TP73, OLIG2, CDKN2A
12MP:00030129.1MGMT, TP53, SYP, PCNA, NRN1, OLIG2
13MP:00053909.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
14MP:00053799.1MGMT, PTEN, TP53, TP73, PCNA, CDKN2A
15MP:00053859.0IGFBP2, GFAP, PTEN, TP53, TP73, LGALS3
16MP:00053759.0PTEN, TP53, PCNA, OLIG2, EGFR
17MP:00053899.0PTEN, TP53, TP73, LGALS3, PCNA, CDKN2A
18MP:00053868.7GFAP, TNC, PTEN, TP53, TP73, NES
19MP:00053768.6TNC, GFAP, IDH1, MGMT, PTEN, TP53
20MP:00053848.6TP73, TP53, PTEN, GFAP, NES, LGALS3
21MP:00053978.5IGFBP2, IDH1, PTEN, TP53, TP73, LGALS3
22MP:00053788.4GFAP, PTEN, TP53, TP73, NES, PCNA
23MP:00053878.4PTEN, GFAP, IDH1, IGFBP2, TP53, TP73
24MP:00036318.2EGFR, GFAP, TNC, PTEN, TP53, TP73
25MP:00107688.2TP73, TP53, PTEN, GFAP, MGMT, NES

Publications for Astrocytoma

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Articles related to Astrocytoma:

(show top 50)    (show all 1966)
idTitleAuthorsYear
1
Long survival in a child with a mutated K27M-H3.3 pilocytic astrocytoma. (25909089)
2015
2
Expression and functional significance of ezrin in human brain astrocytoma. (23712870)
2013
3
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
4
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
5
Expression and biological role of CIP2A in human astrocytoma. (23467938)
2013
6
Correlation of aquaporin-1 water channel protein expression with tumor angiogenesis in human astrocytoma. (23393355)
2013
7
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
8
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
9
Expression of pERK and pAKT in pediatric high grade astrocytomas: correlation with YKL40 and prognostic significance. (21978279)
2012
10
I^-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas. (22505738)
2012
11
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
12
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. (22347337)
2011
13
Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT. (20569675)
2010
14
Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. (19357230)
2009
15
Analysis of interleukin (IL)-8 expression in human astrocytomas: associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. (19332096)
2009
16
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
17
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas. (18713462)
2008
18
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
19
Congenital diffuse anaplastic astrocytoma with ependymal and leptomeningeal spread: case report. (17443288)
2007
20
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis. (17634619)
2007
21
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. (16298472)
2006
22
Immunohistochemical detection of epidermal growth factor receptor in human high-grade astrocytomas--a comparison between frozen- and paraffin sections. (15943037)
2005
23
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas. (15523899)
2004
24
Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. (15255942)
2004
25
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (15367334)
2004
26
Epigenetics in high-grade astrocytomas: opportunities for prevention and detection of brain tumors. (12724228)
2003
27
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (14581362)
2003
28
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. (12747804)
2003
29
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. (12866026)
2003
30
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
31
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
32
Expression and regulation of neuropilin-1 in human astrocytomas. (11058875)
2000
33
Spinal cord astrocytoma: response to PCV chemotherapy. (10668731)
2000
34
Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. (10554042)
1999
35
Astrocytoma cell interaction with elastin substrates: implications for astrocytoma invasive potential. (9890632)
1999
36
Glial fibrillary acidic protein and its fragments discriminate astrocytoma from oligodendroglioma. (10344289)
1999
37
Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma? (10630353)
1999
38
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
39
A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade. (9739111)
1998
40
The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells. (9821106)
1998
41
Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis. (9568761)
1998
42
Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment. (9293896)
1997
43
Immunohistochemical characterization of subependymal giant cell astrocytomas. (8928613)
1996
44
Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. (8290551)
1994
45
Simultaneous quantitation of cytokine mRNAs in interleukin-1 beta stimulated U373 human astrocytoma cells by a polymerisation chain reaction method involving co-amplification with an internal multi-specific control. (1296803)
1992
46
Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells. (1902475)
1991
47
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
48
Intracranial metastasis of a spinal cord astrocytoma--case report. (1694278)
1990
49
Multiple primary intracranial tumors of different cell types: association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature. (7179095)
1982
50
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Astrocytoma

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Cosmic variations for Astrocytoma:

7
id Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Conf
144653TP53central nervous system,spinal cord,glioma,astrocytoma Grade IV3

Expression for genes affiliated with Astrocytoma

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Search GEO for disease gene expression data for Astrocytoma.

Pathways for genes affiliated with Astrocytoma

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Pathways related to Astrocytoma according to GeneCards Suite gene sharing:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1LGALS3, S100B
210.1CDKN2A, TP53
39.9CDK4, TP53, PTEN
4
Show member pathways
9.9CDK4, TP53, PTEN
5
Show member pathways
Prostate Cancer36
Integrated Cancer pathway36
Steroid Biosynthesis36
9.9CDK4, TP53, PTEN
69.9TP53, TP73, CDK4
7
Show member pathways
9.9TP53, CDKN2A, CDK4
89.9CDK4, CDKN2A, TP53
99.9CDK4, CDKN2A, TP53
10
Show member pathways
9.8TP53, TP73, CDKN2A
11
Show member pathways
Apoptosis Modulation and Signaling36
Apoptosis36
9.8TP53, TP73, CDKN2A
129.8GFAP, TNC, SYP, S100B
139.8CDK4, PCNA, TP53
14
Show member pathways
9.8CDK4, PCNA, TP53
159.8CDK4, PCNA, TP53
169.8TP53, PCNA, CDK4
17
Show member pathways
9.8GFAP, PTEN, S100B, EGFR
18
Show member pathways
9.8EGFR, TP53, PTEN, TNC
199.7PTEN, TP53, CDK4, EGFR
209.7EGFR, CDK4, TP53, PTEN
21
Show member pathways
Development EGFR signaling via PIP358
Development PDGF signaling via MAPK cascades58
Apoptosis and survival Anti apoptotic action of membrane bound ESR158
Signaling of Hepatocyte Growth Factor Receptor36
Development EGFR signaling via small GTPases58
Development Neurotrophin family signaling58
Apoptosis and survival NGF signaling pathway58
Apoptosis and survival Role of CDK5 in neuronal death and survival58
9.7PTEN, TP53, TP73, EGFR
22
Show member pathways
9.7EGFR, CDK4, CDKN2A, TP53
23
Show member pathways
DNA damage response (only ATM dependent)36
Wnt Signaling Pathway and Pluripotency36
9.7CDKN2A, TP73, TP53, PTEN
24
Show member pathways
Toll-like receptor signaling pathway36
Regulation of toll-like receptor signaling pathway36
9.6PTEN, TP53, PCNA, CDK4
25
Show member pathways
Signal transduction PTEN pathway58
9.6PTEN, TP53, PCNA, EGFR
269.6PTEN, TP53, PCNA, CDKN2A
279.6TNC, PTEN, TP53, CDK4, EGFR
289.6CDK4, CDKN2A, PCNA, TP53
29
Show member pathways
9.6TP53, PCNA, CDKN2A, CDK4
30
Show member pathways
Cell cycle36
9.6TP53, PCNA, CDKN2A, CDK4
31
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.5IGFBP2, PTEN, TP53, PCNA
329.5GFAP, TP53, LGALS3, CDK4, EGFR
339.5EGFR, CDKN2A, TP53, PTEN, TNC
349.5PTEN, TP53, CDKN2A, CDK4, EGFR
35
Show member pathways
Signaling Pathways in Glioblastoma36
9.5PTEN, TP53, CDKN2A, CDK4, EGFR
36
Show member pathways
DNA damage response36
9.5PTEN, TP53, TP73, CDKN2A, CDK4
379.4PTEN, TP53, PCNA, CDK4, EGFR
389.4EGFR, PCNA, TP73, TP53, PTEN
399.3EGFR, CDK4, CDKN2A, TP53, PTEN, MGMT
40
Show member pathways
9.2GFAP, TNC, PTEN, TP53, CDKN2A, CDK4
41
Show member pathways
9.2MGMT, TP53, TP73, PCNA, CDKN2A, CDK4

Compounds for genes affiliated with Astrocytoma

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Compounds related to Astrocytoma according to GeneCards Suite gene sharing:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1reticulin4310.0GFAP, S100B, PCNA, SYP
2bcnu4310.0EGFR, MGMT, CDKN2A, TP53, GFAP
3olomoucine43 1210.9CDK4, CDKN2A, PCNA, TP53
4dutp439.8PCNA, SYP, LGALS3, TP53, GFAP
5crcs439.8MGMT, TP53, CDKN2A, PTEN
6o6-methylguanine439.8CDKN2A, MGMT, PCNA, TP73, TP53
7silver439.7CDKN2A, PCNA, SYP, TNC, GFAP
8deoxyribonucleic acid439.7MGMT, IGFBP2, PTEN, PCNA, CDKN2A
9gemcitabine43 49 1211.6TP53, PCNA, EGFR, TP73, PTEN
10vincristine43 49 1211.6TP53, TP73, MGMT, CDKN2A, PTEN
11temozolomide43 1210.6NES, TP53, EGFR, CDKN2A, PCNA, MGMT
12thymidylate439.6CDK4, CDKN2A, TP53, MGMT, EGFR, PCNA
13agar439.6CDK4, EGFR, CDKN2A, LGALS3, PTEN, GFAP
14egcg439.6CDKN2A, EGFR, TP53, PCNA, CDK4, MGMT
15bromodeoxyuridine439.5GFAP, CDK4, S100B, PCNA, NES, IGFBP2
16camptothecin43 59 1211.5CDKN2A, PCNA, TP53, TP73, MGMT, CDK4
175-aza-2deoxycytidine439.5PTEN, CDKN2A, TP53, TP73, MGMT, PCNA
18etoposide43 49 59 1212.5TP53, SYP, PTEN, PCNA, S100B, LGALS3
19hematoxylin439.5CDKN2A, GFAP, PCNA, PTEN, S100B, LGALS3
20glycogen43 2410.4IGFBP2, GFAP, PTEN, LGALS3, SYP, CDK4
21doxorubicin43 49 1211.4EGFR, TP53, TP73, CDKN2A, CDK4, PTEN
22thymidine43 2410.3GFAP, IGFBP2, S100B, MGMT, PCNA, TP53
23butyrate439.3PCNA, GFAP, CDKN2A, TP53, LGALS3, CDK4
24leucine439.3CDK4, CDKN2A, IGFBP2, GFAP, PTEN, S100B
25formaldehyde43 2410.3MGMT, PCNA, SYP, S100B, TNC, GFAP
26ly294002439.3EGFR, CDK4, TP53, PTEN, IGFBP2, TNC
27genistein43 28 59 2 24 1214.3CDK4, CDKN2A, PCNA, SYP, PTEN, GFAP
28cycloheximide439.3IGFBP2, TNC, CDKN2A, PTEN, EGFR, GFAP
295fluorouracil439.2PTEN, EGFR, CDKN2A, MGMT, PCNA, TP73
30nitric oxide43 24 1211.2CDKN2A, LGALS3, MGMT, CDK4, SYP, NES
31paclitaxel43 49 1211.1PCNA, S100B, CDKN2A, MGMT, CDK4, GFAP
32mg 13243 5910.1PCNA, CDKN2A, EGFR, TP53, PTEN
33dexamethasone43 49 28 1212.0MGMT, TNC, GFAP, PCNA, S100B, CDKN2A
34glutamate439.0LGALS3, PCNA, IDH1, GFAP, TNC, NES
35testosterone43 59 24 1212.0EGFR, IGFBP2, PCNA, GFAP, SYP, S100B
36cysteine438.9GFAP, MGMT, PTEN, LGALS3, CDK4, CDKN2A
37h2o2438.9TNC, PTEN, TP53, LGALS3, SYP, CDKN2A
38oxygen43 249.8CDKN2A, CDK4, IGFBP2, GFAP, PTEN, NES
39lipid438.8TNC, PTEN, TP73, GFAP, IGFBP2, S100B
40arginine438.8TP73, GFAP, PTEN, PCNA, CDK4, CDKN2A
41oligonucleotide438.7MGMT, IGFBP2, PTEN, TP53, TNC, CDK4
42serine438.7S100B, CDKN2A, EGFR, SYP, TNC, IGFBP2
43cisplatin43 49 59 1211.7EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
44tyrosine438.7IGFBP2, GFAP, EGFR, CDK4, S100B, SYP
45calcium43 49 24 1211.5IDH1, GFAP, IGFBP2, LGALS3, MGMT, TNC
46paraffin438.1CDK4, EGFR, CDKN2A, S100B, PCNA, MGMT
47progesterone43 28 59 24 1211.9IGFBP2, PTEN, TP53, TP73, NES, LGALS3
48vegf437.9EGFR, LGALS3, MGMT, IGFBP2, GFAP, TNC
49estrogen437.9IGFBP2, EGFR, CDK4, PCNA, S100B, CDKN2A
50retinoic acid43 248.5TNC, GFAP, IGFBP2, MGMT, PTEN, TP53

GO Terms for genes affiliated with Astrocytoma

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Cellular components related to Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:00007859.9CDK4, TP73, TP53
2cytoplasmGO:00057377.7TRIM47, IDH1, GFAP, PTEN, TP53, NES
3nucleusGO:00056347.5LGALS3, TP73, TP53, PTEN, MGMT, PCNA

Biological processes related to Astrocytoma according to GeneCards Suite gene sharing:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell sizeGO:004579310.3CDK4, TP73
2long-term synaptic potentiationGO:006029110.3S100B, PTEN, GFAP
3regulation of neuronal synaptic plasticityGO:004816810.3S100B, SYP
4mitotic G1 DNA damage checkpointGO:003157110.3TP73, TP53
5replicative senescenceGO:009039910.3CDKN2A, TP53
6learning or memoryGO:000761110.3EGFR, S100B, PTEN
7response to ethanolGO:004547110.3PTEN, TNC, MGMT
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:000697810.2TP73, TP53
9digestive tract morphogenesisGO:004854610.2EGFR, TP73
10positive regulation of oligodendrocyte differentiationGO:004871410.1TP73, OLIG2
11central nervous system developmentGO:000741710.1S100B, NES, TP53, PTEN
12positive regulation of cell cycle arrestGO:007115810.1CDKN2A, TP53
13response to X-rayGO:001016510.0TP53, TP73
14mismatch repairGO:00062989.9PCNA, TP73
15cell cycle arrestGO:00070509.9TP53, TP73, CDKN2A
16response to drugGO:00424939.9MGMT, IGFBP2, PTEN, CDK4
17positive regulation of cell proliferationGO:00082849.9TNC, PTEN, S100B, CDK4, EGFR
18positive regulation of apoptotic processGO:00430659.9PTEN, TP53, TP73, S100B, CDK4
19phosphatidylinositol-mediated signalingGO:00480159.9EGFR, PCNA, PTEN
20cell proliferationGO:00082839.8PTEN, TP53, PCNA, S100B, EGFR
21G1/S transition of mitotic cell cycleGO:00000829.4CDK4, CDKN2A, PCNA

Molecular functions related to Astrocytoma according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:009737110.1CDKN2A, TP53
2p53 bindingGO:00020399.5CDKN2A, TP73, TP53
3protein kinase bindingGO:00199019.4PTEN, TP53, TP73, CDKN2A, EGFR
4identical protein bindingGO:00428029.2EGFR, S100B, PCNA, SYP, TP73, TP53

Products for genes affiliated with Astrocytoma

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  • Antibodies
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Sources for Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet