MCID: AST007
MIFTS: 72

Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Astrocytoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant glioma that is has material basis in astocyte cells, a type of glial cell, located in the cerebrum.

MalaCards: Astrocytoma, also known as cerebral astrocytoma, is related to subependymal giant cell astrocytoma and tuberous sclerosis. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Rho Family GTPases and PI3K-Akt signaling pathway. The drugs cisplatin and temozolomide and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and spinal cord, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia:63 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Aliases & Classifications for Astrocytoma

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Sources:
8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

astrocytoma 8 44 60
cerebral astrocytoma 8 60
astrocytoma, no icd-o subtype 8
astrocytoma of cerebrum 8
astrocytoma of brain 8
astrocytic tumor 8
astroglioma 8


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Disease Ontology8 DOID:3069
MeSH34 D001254

Related Diseases for Astrocytoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.2TSC1, SYP, S100B
2tuberous sclerosis31.1TSC1, PTEN, GFAP, SYP, NES, S100B
3juvenile pilocytic astrocytoma30.9TNC
4glioblastoma multiforme30.9TP53, TSC1, PTEN, GFAP, CDK4, IGFBP2
5oligodendroglioma30.8TP73, PTEN, GFAP, OLIG2, EGFR, MGMT
6gemistocytic astrocytoma30.7PTEN, GFAP, S100B
7medulloblastoma30.7TP53, TP73, GFAP, CDK4, SYP, NES
8meningioma30.6TP73, TSC1, PTEN, GFAP, PCNA, SYP
9pilocytic astrocytoma30.6TP73, TSC1, LGALS3, PTEN, GFAP, OLIG2
10neuroblastoma30.5TP53, SYP
11anaplastic astrocytoma30.5TP53, TP73, LGALS3, PTEN, GFAP, OLIG2
12malignant glioma30.4TP53, PTEN, GFAP, KIAA1549, OLIG2, PCNA
13ganglioglioma30.2TSC1, GFAP, SYP, S100B
14retinoblastoma30.2TP53, TP73, GFAP, PCNA, CDK4, IGFBP2
15leukemia30.2TP53, TP73, OLIG2, CDK4, IGFBP2, NES
16adenoma30.1TP53, TP73, TSC1, LGALS3, PCNA, CDK4
17dysembryoplastic neuroepithelial tumor30.1KIAA1549, OLIG2, SYP
18hydrocephalus30.1TSC1, NES
19acute leukemia30.1IGFBP2
20adenocarcinoma30.0TP53, TP73, TSC1, LGALS3, PTEN, PCNA
21gliosarcoma30.0PTEN, GFAP, CDK4
22meningitis30.0IGFBP2
23angiomyolipoma30.0TSC1
24brain cancer30.0EGFR, MGMT
25melanoma29.9TP53, TP73, LGALS3, PTEN, PCNA, CDK4
26pituitary adenoma29.9TP73, LGALS3, PCNA, CDK4, SYP, NES
27colon cancer29.9TP53, TP73, LGALS3, CDK4, IGFBP2, EGFR
28lung small cell carcinoma29.9TP53, IGFBP2, SYP, EGFR, MGMT
29hemangioblastoma29.9GFAP, SYP, NES, S100B
30giant cell glioblastoma29.9PTEN, GFAP, EGFR
31central neurocytoma29.9GFAP, OLIG2, SYP
32oligoastrocytoma29.9GFAP, MGMT
33gangliocytoma29.9PTEN, SYP
34breast cancer29.7TP53, TP73, TSC1, LGALS3, PTEN, PCNA
35prostate cancer29.7TP53, TP73, LGALS3, PTEN, PCNA, CDK4
36colorectal cancer29.7TP53, TP73, LGALS3, PTEN, PCNA, IGFBP2
37neurofibroma29.6TP73, SYP, TNC, S100B
38pleomorphic adenoma29.6GFAP, PCNA, TNC, S100B
39papilloma29.6TP53, TP73, PCNA
40osteosarcoma29.6TP53, TP73, CDK4
41chordoma29.6LGALS3, GFAP, S100B
42multiple sclerosis29.6GFAP, OLIG2, IGFBP2, TNC
43xeroderma pigmentosum29.6TP53, PCNA, MGMT
44alzheimer's disease29.6TSC1, GFAP, SYP, S100B
45lung adenocarcinoma29.6TP53, TP73, EGFR, MGMT
46gliomatosis cerebri29.6PTEN, GFAP
47fibrosarcoma29.6NES, TNC
48myeloid leukemia29.6TP73, CDK4
49neurilemmoma29.6GFAP, NES, S100B
50pineoblastoma29.6GFAP, SYP

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Clinical Features for Astrocytoma

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Drugs & Therapeutics for Astrocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Search CenterWatch for Astrocytoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Astrocytoma

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Anatomical Context for Astrocytoma

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Astrocytoma:

32
Brain, Spinal cord, Endothelial, Cerebellum, Pituitary, Pineal, Cortex, Temporal lobe, Breast, Thyroid, Monocytes, Testes, Ovary, Colon, Eye, T cells, Retina, Hypothalamus, Lung, Testis, Tongue, Bone, Medulla oblongata, Bone marrow, Prefrontal cortex, B cells, Myeloid, Prostate, Liver, Skin

FMA organs/tissues related to Astrocytoma:

14
The cerebrum

Animal Models for Astrocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Astrocytoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.7GFAP, NRN1, CDK4, PCNA, OLIG2, PTEN
2MP:001076812.7CDK4, EGFR, NES, TSC1, LGALS3, PTEN
3MP:000538612.6TNC, TP73, TP53, GFAP, OLIG2, CDK4
4MP:000537812.5EGFR, NRN1, CDK4, PCNA, OLIG2, GFAP
5MP:000538712.4CDK4, TP53, TP73, LGALS3, PTEN, PCNA
6MP:000363112.3GFAP, TP73, TSC1, LGALS3, SYP, NRN1
7MP:000538512.2TP53, PTEN, CDK4, LGALS3, TSC1, TP73
8MP:000539712.1EGFR, CDK4, IDH1, TP53, PTEN, PCNA
9MP:000287312.0TP53, EGFR, S100B, TNC, PTEN, GFAP
10MP:000200611.9TP73, TSC1, PTEN, OLIG2, CDK4, EGFR
11MP:000301211.8OLIG2, MGMT, SYP, EGFR, TP53, NRN1
12MP:000538811.8LGALS3, TP73, TSC1, OLIG2, EGFR, TP53
13MP:000538111.8GFAP, PTEN, CDK4, EGFR, TP53, TP73
14MP:000537611.7TNC, MGMT, CDK4, GFAP, IDH1, TSC1
15MP:000538911.6PTEN, TP73, PCNA, TSC1, EGFR, TP53
16MP:000537911.4MGMT, CDK4, TP73, TP53
17MP:000536911.4CDK4, TSC1, GFAP, TP53, OLIG2
18MP:000536711.2EGFR, LGALS3, TSC1
19MP:001077111.2TP53, TSC1, PTEN, CDK4, S100B
20MP:000537011.1TP53, TSC1, PTEN, CDK4, IGFBP2, EGFR
21MP:000539011.0LGALS3, TSC1, OLIG2
22MP:000539110.9EGFR, GFAP
23MP:000538010.8NES, TSC1

Publications for Astrocytoma

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Sources:
50PubMed
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Articles related to Astrocytoma:

(show top 50)    (show all 1876)
idTitleAuthorsYear
1
Metachronous, multicentric glioma of pilocytic astrocytoma with oligodendroglioma-like component and oligodendroglioma through distinct genetic aberrations. (23082883)
2013
2
Subependymal giant cell astrocytoma with intratumoral hemorrhage. (23414132)
2013
3
Anaplastic astrocytoma masquerading as hemorrhagic stroke. (23510543)
2013
4
IDH1 mutations in grade II astrocytomas are associated with unfavorable progression-free survival and prolonged postrecurrence survival. (21717448)
2012
5
A fraction of neurofibromin interacts with PML bodies in the nucleus of the CCF astrocytoma cell line. (22293200)
2012
6
Diencephalic juvenile pilomyxoid astrocytoma with leptomeningeal dissemination. (21534206)
2011
7
Infiltrating growing pattern xenografts induced by glioblastoma and anaplastic astrocytoma derived tumor stem cells. (21141095)
2010
8
Cerebellar glioblastoma multiforme with non-contiguous grade 2 astrocytoma of the temporal lobe in the same individual. (20739816)
2010
9
A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. (20531304)
2010
10
The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6. (20815783)
2010
11
Corneal verticillata after dual anti-epidermal growth factor receptor and anti-vascular endothelial growth factor receptor 2 therapy (vandetanib) for anaplastic astrocytoma. (19512898)
2009
12
Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient. (19537133)
2009
13
Expression of stem cell markers in human astrocytomas of different WHO grades. (17611714)
2008
14
Proliferation and programmed cell death: role of p53 protein in high and low grade astrocytoma. (18383819)
2008
15
Utility of EGFR and PTEN numerical aberrations in the evaluation of diffusely infiltrating astrocytomas. Laboratory investigation. (18240930)
2008
16
Cerebral phaeohyphomycosis mimics high-grade astrocytoma. (18614370)
2008
17
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
18
Qualitative and quantitative analysis of cytologic assessment of astrocytoma, oligodendroglioma and oligoastrocytoma. (18077983)
2007
19
Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma. (16896310)
2006
20
Metachronous secondary atypical meningioma and anaplastic astrocytoma after postoperative craniospinal irradiation for medulloblastoma. (16570196)
2006
21
Interleukin-1 beta-induced expression of the prostaglandin E-receptor subtype EP3 in U373 astrocytoma cells depends on protein kinase C and nuclear factor-kappaB. (16405508)
2006
22
BCR gene disruption in a pilomyxoid astrocytoma. (17080723)
2006
23
Isolated oculomotor nerve paresis in anaplastic astrocytoma with exophytic invasion. (16636512)
2006
24
Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array. (17034947)
2006
25
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (15367334)
2004
26
Safety and efficacy of high-dose chemotherapy with autologous stem cell transplantation for patients with malignant astrocytomas. (15139065)
2004
27
Lymphokine activated killer cells from umbilical cord blood show higher antitumor effect against anaplastic astrocytoma cell line (U87) and medulloblastoma cell line (TE671) than lymphokine activated killer cells from peripheral blood. (14968374)
2004
28
Astrocytoma of the pituitary gland (pituicytoma): case report. (11942363)
2002
29
Expression and hypoxic regulation of angiopoietins in human astrocytomas. (11305411)
2001
30
Spontaneous cerebellar hemorrhage due to a juvenile pilocytic astrocytoma: case report and review of the literature. (11423772)
2001
31
A clinicopathologic reappraisal of brain stem tumor classification. Identification of pilocystic astrocytoma and fibrillary astrocytoma as distinct entities. (11013373)
2000
32
Anaplastic astrocytoma invading the optic chiasm through the optic pathway. (11014557)
2000
33
Acquired cerebral arteriovenous malformation induced by an anaplastic astrocytoma: an interesting case. (10935219)
2000
34
Astrocytoma cell interaction with elastin substrates: implications for astrocytoma invasive potential. (9890632)
1999
35
Mechanism of thrombin clearance by human astrocytoma cells. (10037469)
1999
36
Expression of vascular endothelial growth factor in brain astrocytoma and its clinical evaluation]. (12205936)
1999
37
Low density lipoprotein receptor related protein gene amplification and 766T polymorphism in astrocytomas. (9832203)
1998
38
Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain? (9077524)
1997
39
Preclinical studies on thymidine kinase gene (TK) and gancyclovir system for treatment of malignant astrocytoma]. (9596975)
1997
40
Thrombin receptors modulate insulin-stimulated phosphatidylinositol 3,4,5-trisphosphate accumulation in 1321N1 astrocytoma cells. (8713057)
1996
41
Hemorrhagic subependymal giant cell astrocytoma. (7761172)
1995
42
The lack of a role for p53 in astrocytomas in pediatric patients. (8084407)
1994
43
Expression of granulocyte colony stimulating factor and granulocyte-macrophage colony stimulating factor genes in human astrocytoma cell lines and in glioma specimens. (1377084)
1992
44
Human malignant astrocytoma xenografts migrate in rat brain: a model for central nervous system cancer research. (2651679)
1989
45
Effect of retinoids on the proliferation, morphology and expression of glial fibrillary acidic protein of an anaplastic astrocytoma cell line. (3417370)
1988
46
Anaplastic astrocytoma mimicking metastatic carcinoma. (3532839)
1986
47
Post laminectomy kyphoscoliosis following surgical treatment for spinal cord astrocytoma. (3960792)
1986
48
Diffuse infiltrating astrocytoma (gliomatosis cerebri) with twenty-two-year history. (6568933)
1983
49
Anaplastic astrocytoma following radiation for a glomus jugular tumor. (222421)
1979
50
Precocious puberty--unusual manifestation of cerebellar astrocytoma. (924642)
1977

Genetic Variations for Astrocytoma

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Expression for genes affiliated with Astrocytoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Astrocytoma

Search GEO for disease gene expression data for Astrocytoma.

Pathways for genes affiliated with Astrocytoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome
See all sources

Pathways related to Astrocytoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.6EGFR, TNC, PTEN, TSC1, TP53, CDK4
211.4EGFR, TSC1, TNC, TP53, PTEN, CDK4
311.4PTEN, TP53, TSC1, CDK4, EGFR, MGMT
411.3EGFR, CDK4, GFAP, TP53, LGALS3
511.3TP53, TSC1, EGFR, PTEN, CDK4
611.3PTEN, CDK4, TP53, EGFR, TSC1
711.3TP53, PTEN, PCNA, CDK4, EGFR
811.3EGFR, TP53, TP73, PTEN, PCNA
9
Hide members
11.3TP53, PTEN, TSC1, IGFBP2, PCNA
1011.1S100B, TNC, SYP, GFAP
11
Hide members
11.1PTEN, GFAP, EGFR, S100B
1211.1TNC, PTEN, EGFR, TP53
13
Hide members
11.1TP53, TP73, PTEN, CDK4
14
Hide members
11.1EGFR, PTEN, TP73, TP53
15
Hide members
11.1PTEN, CDK4, TSC1, TP53
16
Hide members
11.1CDK4, PCNA, PTEN, TP53
17
Hide members
11.1PTEN, TP53, PCNA, EGFR
18
Hide members
11.1MGMT, CDK4, PCNA, TP73
1911.0CDK4, PTEN, TP53
2011.0CDK4, TP53, MGMT
21
Hide members
11.0EGFR, CDK4, TP53
2211.0CDK4, PCNA, TP53
2311.0PCNA, CDK4, TP53
2410.8LGALS3, S100B
25
Hide members
10.8TP73, TP53
26
Hide members
10.8TP53, TSC1

Compounds for genes affiliated with Astrocytoma

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
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Compounds related to Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1vegf4413.3TNC, MGMT, EGFR, NES, SYP, IGFBP2
2retinoic acid44 2414.3OLIG2, GFAP, PTEN, LGALS3, TP73, TP53
3progesterone44 59 28 11 2417.2TNC, S100B, MGMT, EGFR, NES, SYP
4paraffin4413.1S100B, TP53, TP73, TSC1, LGALS3, TNC
5tyrosine4412.8PTEN, LGALS3, TP73, CDK4, IGFBP2, GFAP
6cisplatin44 49 59 1115.5EGFR, TP73, SYP, GFAP, LGALS3, PTEN
7oligonucleotide4412.3TP73, TNC, TP53, LGALS3, PTEN, CDK4
8arginine4412.3TP53, TP73, LGALS3, PTEN, GFAP, PCNA
9cysteine4412.3S100B, TNC, LGALS3, MGMT, SYP, CDK4
10lipid4412.2GFAP, TP73, LGALS3, IGFBP2, SYP, NES
11formaldehyde44 2413.2IGFBP2, PCNA, SYP, MGMT, TNC, LGALS3
12glycogen44 2413.2CDK4, SYP, S100B, IGFBP2, LGALS3, TSC1
13testosterone44 59 11 2415.1PTEN, EGFR, SYP, IGFBP2, CDK4, PCNA
145fluorouracil4412.0CDK4, TP73, MGMT, PTEN, PCNA, EGFR
15genistein44 28 59 2 11 2417.0PCNA, CDK4, MGMT, PTEN, GFAP, EGFR
16thymidine44 2412.9GFAP, PCNA, CDK4, IGFBP2, TP53, S100B
17hematoxylin4411.9S100B, PCNA, SYP, LGALS3, PTEN, GFAP
18paclitaxel44 49 1113.9PTEN, TP53, CDK4, GFAP, EGFR, S100B
19bromodeoxyuridine4411.8PCNA, GFAP, CDK4, IGFBP2, NES, S100B
20temozolomide44 1112.7NES, EGFR, MGMT, TP53, PCNA
21dutp4411.7TP53, SYP, PCNA, GFAP, LGALS3
22doxorubicin44 49 1113.7TP53, MGMT, CDK4, PTEN, TP73, EGFR
23gemcitabine44 49 1113.6TP73, TP53, PTEN, EGFR, PCNA
24dexamethasone44 49 28 1114.6S100B, MGMT, CDK4, PCNA, GFAP
25thymidylate4411.6PCNA, TP53, MGMT, CDK4, EGFR
26camptothecin44 59 1113.6TP53, CDK4, MGMT, PCNA, TP73
27phosphatidylinositol4411.6TSC1, IGFBP2, TNC, LGALS3, PTEN, EGFR
28proline4411.6TP73, TP53, MGMT, S100B, LGALS3, CDK4
29glutamine4411.5S100B, PCNA, SYP, GFAP, LGALS3, IDH1
30reticulin4411.5S100B, SYP, PCNA, GFAP
315-aza-2deoxycytidine4411.5PTEN, PCNA, TP73, TP53, MGMT
32serine4411.5TSC1, GFAP, SYP, S100B
33bcnu4411.5TP53, GFAP, EGFR, MGMT
34o6-methylguanine4411.5TP73, TP53, MGMT, PCNA
35glucose4411.5MGMT, IGFBP2, PTEN, GFAP, TSC1
36acth4411.4SYP, LGALS3, IGFBP2, GFAP, S100B
37ly2940024411.4CDK4, EGFR, TNC, IGFBP2
38deoxyribonucleic acid4411.4PCNA, IGFBP2, MGMT, PTEN
39estradiol44 11 2413.3PTEN, SYP, GFAP, CDK4
40eosin4411.3S100B, PCNA, GFAP
41agar4411.3EGFR, LGALS3, CDK4, GFAP, PTEN
42s 1004411.3S100B, SYP, GFAP
43streptozotocin4411.2NES, GFAP, SYP
44etoposide44 49 59 1114.2S100B, LGALS3
45carboplatin44 49 1113.2TP53, CDK4, EGFR, MGMT
46gaba4411.2TNC, S100B, NES, SYP, GFAP
47glutamate4411.1GFAP, IDH1
48estrogen4411.1GFAP
49cycloheximide4411.0IGFBP2
50silver4410.8GFAP, PCNA, SYP, TNC

GO Terms for genes affiliated with Astrocytoma

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Sources:
16Gene Ontology
See all sources

Cellular components related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1IDH1, S100B, EGFR, NES, TRIM47, PCNA
2chromatinGO:00078511.0CDK4, TP73, TP53

Biological processes related to Astrocytoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:00828311.4S100B, EGFR, PCNA, PTEN, TP53
2positive regulation of cell proliferationGO:00828411.4S100B, TNC, EGFR, CDK4, PTEN
3central nervous system developmentGO:00741711.3TP53, PTEN, NES, S100B
4long-term synaptic potentiationGO:06029111.2S100B, GFAP, PTEN
5positive regulation of cell sizeGO:04579310.9CDK4, TP73
6negative regulation of cell sizeGO:04579210.9PTEN, TSC1
7positive regulation of apoptotic processGO:04306510.8S100B, TP53, TP73, CDK4
8positive regulation of oligodendrocyte differentiationGO:04871410.8TP73, OLIG2
9DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.8TP73, TP53
10mitotic G1 DNA damage checkpointGO:03157110.7TP53, TP73

Molecular functions related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.4TP53, TP73, PCNA, SYP, EGFR, S100B

Products for genes affiliated with Astrocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet