MCID: AST007
MIFTS: 70

Astrocytoma malady

Neuronal, Cancer categories

Summaries for Astrocytoma

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
See all sources

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Disease Ontology:8 A malignant glioma that is has material basis in astocyte cells, a type of glial cell, located in the cerebrum.

MalaCards: Astrocytoma, also known as cerebral astrocytoma, is related to pilocytic astrocytoma and anaplastic astrocytoma. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Rho Family GTPases and PI3K-Akt signaling pathway. The drugs cisplatin and temozolomide and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, bone marrow and brain, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia:64 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Aliases & Classifications for Astrocytoma

Sources:
8Disease Ontology, 45Novoseek, 61UMLS, 57SNOMED-CT, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer
Anatomical: Neuronal


Aliases & Descriptions:

astrocytoma 8 45 61
cerebral astrocytoma 8 61
astrocytoma, no icd-o subtype 8
astrocytoma of cerebrum 8
astrocytoma of brain 8
astrocytic tumor 8
astroglioma 8


External Ids:

Disease Ontology8 DOID:3069
MeSH35 D001254

Related Diseases for Astrocytoma

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Astrocytoma family:

juvenile astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 299)
idRelated DiseaseScoreTop Affiliating Genes
1pilocytic astrocytoma31.6TP73, TSC1, LGALS3, PTEN, GFAP, OLIG2
2anaplastic astrocytoma31.5TP53, TP73, LGALS3, PTEN, GFAP, OLIG2
3subependymal giant cell astrocytoma31.3TSC1, SYP, S100B
4tuberous sclerosis31.1TSC1, PTEN, GFAP, SYP, NES, S100B
5juvenile pilocytic astrocytoma31.0TNC
6tuberous sclerosis complex30.9TSC1
7gemistocytic astrocytoma30.7PTEN, GFAP, S100B
8ependymoma30.6TP73, GFAP, SYP, NES, EGFR, MGMT
9oligoastrocytoma30.4GFAP, MGMT
10anaplastic oligodendroglioma30.3LGALS3, PTEN, GFAP, OLIG2, CDK4, IGFBP2
11ganglioglioma30.3TSC1, GFAP, SYP, S100B
12adenoma30.2TP53, TP73, TSC1, LGALS3, PCNA, CDK4
13dysembryoplastic neuroepithelial tumor30.2KIAA1549, OLIG2, SYP
14acute leukemia30.1IGFBP2
15turcot syndrome30.1PTEN
16adenocarcinoma30.1TP53, TP73, TSC1, LGALS3, PTEN, PCNA
17gliosarcoma30.1PTEN, GFAP, CDK4
18angiomyolipoma30.1TSC1
19brain cancer30.1EGFR, MGMT
20oral cancer29.9TP53, TP73, PCNA, CDK4, EGFR, MGMT
21giant cell glioblastoma29.9PTEN, GFAP, EGFR
22central neurocytoma29.9GFAP, OLIG2, SYP
23wilms tumor29.9TP73
24gangliocytoma29.9PTEN, SYP
25colorectal cancer29.7TP53, TP73, LGALS3, PTEN, PCNA, IGFBP2
26pleomorphic adenoma29.7GFAP, PCNA, TNC, S100B
27anaplastic ependymoma29.7PTEN, GFAP, S100B
28xeroderma pigmentosum29.7TP53, PCNA, MGMT
29gliomatosis cerebri29.7PTEN, GFAP
30myxopapillary ependymoma29.7GFAP, S100B
31choroid plexus carcinoma29.7GFAP, S100B
32diffuse astrocytoma10.8
33spinal cord astrocytoma10.7
34pilomyxoid astrocytoma10.7
35juvenile astrocytoma10.7
36fibrillary astrocytoma10.6
37neurofibromatosis10.5
38cerebellar astrocytoma, childhood10.5
39desmoplastic infantile astrocytoma10.4
40protoplasmic astrocytoma10.3
41melanoma astrocytoma syndrome10.3
42childhood cerebral astrocytoma10.3
43pineal gland astrocytoma10.2
44pleomorphic xanthoastrocytoma10.2
45diencephalic syndrome10.2
46pituicytoma10.2
47desmoplastic infantile astrocytoma/ganglioglioma10.2
48mixed astrocytoma-ependymoma10.2
49mixed oligodendroglioma-astrocytoma10.2
50diencephalic astrocytomas10.2

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Clinical Features for Astrocytoma

Drugs & Therapeutics for Astrocytoma

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Search CenterWatch for Astrocytoma

Inferred drug relations via UMLS61/NDF-RT41:

Genetic Tests for Astrocytoma

Anatomical Context for Astrocytoma

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Astrocytoma:

33
Bone marrow, Brain, Cortex, Cerebellum, Retina, Spinal cord, Skeletal muscle, Colon, Liver, Lung, Thyroid, Breast, Skin, Ovary, Prostate, Testis, Myeloid, Monocytes, T cells, B lymphoblasts, B cells, Endothelial, Fetal brain, Prefrontal cortex, Temporal lobe, Occipital lobe, Hypothalamus, Medulla oblongata, Dorsal root ganglion, Tongue, Fetal liver, Fetal lung, Fetal thyroid, Pineal, Pituitary, Testis germ, Testis leydig

FMA organs/tissues related to Astrocytoma:

14
The cerebrum

Animal Models for Astrocytoma or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Astrocytoma:

37 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.7GFAP, NRN1, CDK4, PCNA, OLIG2, PTEN
2MP:001076812.7CDK4, EGFR, NES, TSC1, LGALS3, PTEN
3MP:000538612.6TNC, TP73, TP53, GFAP, OLIG2, CDK4
4MP:000537812.5EGFR, NRN1, CDK4, PCNA, OLIG2, GFAP
5MP:000538712.4CDK4, TP53, TP73, LGALS3, PTEN, PCNA
6MP:000363112.3GFAP, TP73, TSC1, LGALS3, SYP, NRN1
7MP:000538512.2TP53, PTEN, CDK4, LGALS3, TSC1, TP73
8MP:000539712.1EGFR, CDK4, IDH1, TP53, PTEN, PCNA
9MP:000287312.0TP53, EGFR, S100B, TNC, PTEN, GFAP
10MP:000200611.9TP73, TSC1, PTEN, OLIG2, CDK4, EGFR
11MP:000301211.8OLIG2, MGMT, SYP, EGFR, TP53, NRN1
12MP:000538811.8LGALS3, TP73, TSC1, OLIG2, EGFR, TP53
13MP:000538111.8GFAP, PTEN, CDK4, EGFR, TP53, TP73
14MP:000537611.7TNC, MGMT, CDK4, GFAP, IDH1, TSC1
15MP:000538911.6PTEN, TP73, PCNA, TSC1, EGFR, TP53
16MP:000537911.4MGMT, CDK4, TP73, TP53
17MP:000536911.4CDK4, TSC1, GFAP, TP53, OLIG2
18MP:000536711.2EGFR, LGALS3, TSC1
19MP:001077111.2TP53, TSC1, PTEN, CDK4, S100B
20MP:000537011.1TP53, TSC1, PTEN, CDK4, IGFBP2, EGFR
21MP:000539011.0LGALS3, TSC1, OLIG2
22MP:000539110.9EGFR, GFAP
23MP:000538010.8NES, TSC1

Publications for Astrocytoma

Sources:
51PubMed
See all sources

Articles related to Astrocytoma:

(show top 50)    (show all 1877)
idTitleAuthorsYear
1
A management strategy for intraventricular subependymal giant cell astrocytomas in tuberous sclerosis complex. (24180681)
2014
2
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
3
Molecular interactions of ErbB1 (EGFR) and integrin-I^1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance. (23595626)
2013
4
Profiling and sequence analysis of gangliosides in human astrocytoma by high-resolution mass spectrometry. (23877172)
2013
5
Pilocytic astrocytoma with leptomeningeal dissemination. (23207974)
2013
6
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
7
Analysis of risk factors and survival in pediatric high-grade spinal cord astrocytoma: a population-based study. (23881025)
2012
8
Efficient genetic manipulation of 1321N1 astrocytoma cells using lentiviral gene transfer. (22387260)
2012
9
Pilocytic astrocytoma originating at the cavernous sinus. (21892636)
2012
10
Proteomics studies of childhood pilocytic astrocytoma. (21466243)
2011
11
FRAT1 expression and its correlation with pathologic grade, proliferation, and apoptosis in human astrocytomas. (20041315)
2011
12
Genome-wide polymorphism analysis demonstrates a monoclonal origin of pilocytic astrocytoma. (20646217)
2011
13
Proliferation inhibition, DNA damage, and cell-cycle arrest of human astrocytoma cells after acrylamide exposure. (20734998)
2010
14
Collision tumor of meningioma and malignant astrocytoma. (21389747)
2010
15
Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma. (21059263)
2010
16
MGMT activity, promoter methylation and immunohistochemistry of pretreatment and recurrent malignant gliomas: a comparative study on astrocytoma and glioblastoma. (20131314)
2010
17
Subtelomeric analysis of pediatric astrocytoma: subchromosomal instability is a distinctive feature of pleomorphic xanthoastrocytoma. (19099200)
2009
18
Acute v pattern esotropia without abduction deficit, secondary to a posterior fossa pilocytic astrocytoma. (19645405)
2009
19
Regulation of progesterone receptor isoforms content in human astrocytoma cell lines. (19095059)
2009
20
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
21
Magnetic resonance imaging characteristics of pilomyxoid astrocytoma. (18662499)
2008
22
Comparison between cells and cancer stem-like cells isolated from glioblastoma and astrocytoma on expression of anti-apoptotic and multidrug resistance-associated protein genes. (18462887)
2008
23
Multifocal anaplastic astrocytoma in a patient with hereditary colorectal cancer, transcobalamin II deficiency, agenesis of the corpus callosum, mental retardation, and inherited PMS2 mutation. (17993636)
2008
24
Aldehydic lipid peroxidation products in human brain astrocytomas. (17487452)
2007
25
Fascicular multiple ocular motor nerve paresis as first presentation of anaplastic astrocytoma. (17951905)
2007
26
Expression of HOXC9 and E2F2 are up-regulated in CD133(+) cells isolated from human astrocytomas and associate with transformation of human astrocytes. (17588684)
2007
27
Congenital gemistocytic astrocytoma in a fetus. (15864706)
2006
28
No aberrant methylation of neurofibromatosis 1 gene (NF1) promoter in pilocytic astrocytoma in childhood. (15770836)
2005
29
Phase II trial of carmustine, cisplatin, and oral etoposide chemotherapy before radiotherapy for grade 3 astrocytoma (anaplastic astrocytoma): results of North Central Cancer Treatment Group trial 98-72-51. (15667956)
2005
30
High expression of Aurora-B/Aurora and Ipll-like midbody-associated protein (AIM-1) in astrocytomas. (15072448)
2004
31
Molecular markers that identify human astrocytomas and oligodendrogliomas. (11939588)
2002
32
Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis. (11137571)
2001
33
The A3 adenosine receptor induces cytoskeleton rearrangement in human astrocytoma cells via a specific action on Rho proteins. (11462805)
2001
34
p53 and vascular endothelial growth factor expression in astrocytoma and their relation to angiogenesis]. (11783119)
2001
35
Prognostic value of the expression of tumor suppressor genes p53, p21, p16 and prb, and Ki-67 labelling in high grade astrocytomas treated with radiotherapy. (10896207)
2000
36
Cholesterol homeostasis in rat astrocytoma cells GA-1. (11056397)
2000
37
Co-expression of nestin and vimentin intermediate filaments in invasive human astrocytoma cells. (10571412)
1999
38
Cerebellar astrocytoma presenting with acute esotropia in a 5 year-old girl. Case report. (11456255)
1999
39
Characterization of glial filament-cytoskeletal interactions in human astrocytomas: an immuno-ultrastructural analysis. (9765058)
1998
40
Proliferation of human malignant astrocytomas is dependent on Ras activation. (9419966)
1997
41
Molecular variants of epidermal growth factor in malignant astrocytoma. (8822528)
1996
42
Expression of bFGF and VEGF in brain astrocytoma. (8835763)
1996
43
Radiology rounds. Cerebellar astrocytoma. (7580377)
1995
44
The mechanism of muscarinic receptor-stimulated phosphatidylinositol resynthesis in 1321N1 astrocytoma cells and its inhibition by Li+. (7595517)
1995
45
Timing of p53 mutations during astrocytoma tumorigenesis. (8268922)
1993
46
Cytokine-induced nitric oxide generation by cultured astrocytoma cells involves Ca(++)-calmodulin-independent NO-synthase. (7681665)
1993
47
Distribution of transforming growth factor-beta 1 in human astrocytomas. (1427755)
1992
48
Pilocytic astrocytoma of the optic nerve with hemorrhage and extreme cystic degeneration. (7304696)
1981
49
Cerebellar astrocytoma invading the musculature and soft tissues of the neck. Case report. (7359199)
1980
50
Pineocytoma with astrocytomatous differentiation. (438866)
1979

Genetic Variations for Astrocytoma

Expression for genes affiliated with Astrocytoma

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Astrocytoma

Search GEO for disease gene expression data for Astrocytoma.

Pathways for genes affiliated with Astrocytoma

Sources:
52QIAGEN, 30KEGG, 38NCBI BioSystems Database, 53R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 54Reactome
See all sources

Pathways related to Astrocytoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6TNC, EGFR, CDK4, GFAP, PTEN, TSC1
211.4TNC, EGFR, CDK4, PTEN, TSC1, TP53
311.4TP53, TSC1, PTEN, CDK4, EGFR, MGMT
411.3TP53, LGALS3, GFAP, CDK4, EGFR
511.3EGFR, CDK4, PTEN, TSC1, TP53
611.3EGFR, CDK4, PTEN, TSC1, TP53
711.3EGFR, CDK4, PCNA, PTEN, TP53
811.3EGFR, PCNA, PTEN, TP73, TP53
9
Hide members
11.3IGFBP2, PCNA, PTEN, TSC1, TP53
1011.1GFAP, SYP, TNC, S100B
11
Hide members
11.1S100B, EGFR, GFAP, PTEN
1211.1TP53, PTEN, EGFR, TNC
13
Hide members
11.1TP53, TP73, PTEN, CDK4
14
Hide members
11.1EGFR, PTEN, TP73, TP53
15
Hide members
11.1CDK4, PTEN, TSC1, TP53
16
Hide members
11.1CDK4, PCNA, PTEN, TP53
17
Hide members
11.1EGFR, PCNA, PTEN, TP53
18
Hide members
11.1MGMT, CDK4, PCNA, TP73
1911.0TP53, PTEN, CDK4
2011.0TP53, CDK4, MGMT
21
Hide members
11.0EGFR, CDK4, TP53
2211.0TP53, PCNA, CDK4
2311.0TP53, PCNA, CDK4
2410.8LGALS3, S100B
25
Hide members
10.8TP73, TP53
26
Hide members
10.8TP53, TSC1

Compounds for genes affiliated with Astrocytoma

Sources:
45Novoseek, 24HMDB, 60Tocris Bioscience, 29IUPHAR, 11DrugBank, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1vegf4513.3TNC, MGMT, EGFR, NES, SYP, IGFBP2
2retinoic acid45 2414.3OLIG2, GFAP, PTEN, LGALS3, TP73, TP53
3progesterone45 60 29 11 2417.2TNC, S100B, MGMT, EGFR, NES, SYP
4paraffin4513.1S100B, TP53, TP73, TSC1, LGALS3, TNC
5tyrosine4512.8PTEN, LGALS3, TP73, CDK4, IGFBP2, GFAP
6cisplatin45 50 60 1115.5EGFR, TP73, SYP, GFAP, LGALS3, PTEN
7oligonucleotide4512.3TP73, TNC, TP53, LGALS3, PTEN, CDK4
8arginine4512.3TP53, TP73, LGALS3, PTEN, GFAP, PCNA
9cysteine4512.3S100B, TNC, LGALS3, MGMT, SYP, CDK4
10lipid4512.2GFAP, TP73, LGALS3, IGFBP2, SYP, NES
11formaldehyde45 2413.2IGFBP2, PCNA, SYP, MGMT, TNC, LGALS3
12glycogen45 2413.2CDK4, SYP, S100B, IGFBP2, LGALS3, TSC1
13testosterone45 60 11 2415.1PTEN, EGFR, SYP, IGFBP2, CDK4, PCNA
145fluorouracil4512.0CDK4, TP73, MGMT, PTEN, PCNA, EGFR
15genistein45 29 60 2 11 2417.0PCNA, CDK4, MGMT, PTEN, GFAP, EGFR
16thymidine45 2412.9GFAP, PCNA, CDK4, IGFBP2, TP53, S100B
17hematoxylin4511.9S100B, PCNA, SYP, LGALS3, PTEN, GFAP
18paclitaxel45 50 1113.9PTEN, TP53, CDK4, GFAP, EGFR, S100B
19bromodeoxyuridine4511.8PCNA, GFAP, CDK4, IGFBP2, NES, S100B
20temozolomide45 1112.7NES, EGFR, MGMT, TP53, PCNA
21dutp4511.7TP53, SYP, PCNA, GFAP, LGALS3
22doxorubicin45 50 1113.7TP53, MGMT, CDK4, PTEN, TP73, EGFR
23gemcitabine45 50 1113.6TP73, TP53, PTEN, EGFR, PCNA
24dexamethasone45 50 29 1114.6S100B, MGMT, CDK4, PCNA, GFAP
25thymidylate4511.6PCNA, TP53, MGMT, CDK4, EGFR
26camptothecin45 60 1113.6TP53, CDK4, MGMT, PCNA, TP73
27phosphatidylinositol4511.6TSC1, IGFBP2, TNC, LGALS3, PTEN, EGFR
28proline4511.6TP73, TP53, MGMT, S100B, LGALS3, CDK4
29glutamine4511.5S100B, PCNA, SYP, GFAP, LGALS3, IDH1
30reticulin4511.5S100B, SYP, PCNA, GFAP
315-aza-2deoxycytidine4511.5PTEN, PCNA, TP73, TP53, MGMT
32serine4511.5TSC1, GFAP, SYP, S100B
33bcnu4511.5TP53, GFAP, EGFR, MGMT
34o6-methylguanine4511.5TP73, TP53, MGMT, PCNA
35glucose4511.5MGMT, IGFBP2, PTEN, GFAP, TSC1
36acth4511.4SYP, LGALS3, IGFBP2, GFAP, S100B
37ly2940024511.4CDK4, EGFR, TNC, IGFBP2
38deoxyribonucleic acid4511.4PCNA, IGFBP2, MGMT, PTEN
39estradiol45 11 2413.3PTEN, SYP, GFAP, CDK4
40eosin4511.3S100B, PCNA, GFAP
41agar4511.3EGFR, LGALS3, CDK4, GFAP, PTEN
42s 1004511.3S100B, SYP, GFAP
43streptozotocin4511.2NES, GFAP, SYP
44etoposide45 50 60 1114.2S100B, LGALS3
45carboplatin45 50 1113.2TP53, CDK4, EGFR, MGMT
46gaba4511.2TNC, S100B, NES, SYP, GFAP
47glutamate4511.1GFAP, IDH1
48estrogen4511.1GFAP
49cycloheximide4511.0IGFBP2
50silver4510.8GFAP, PCNA, SYP, TNC

GO Terms for genes affiliated with Astrocytoma

Sources:
16Gene Ontology
See all sources

Cellular components related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1IDH1, S100B, EGFR, NES, TRIM47, PCNA
2chromatinGO:00078511.0CDK4, TP73, TP53

Biological processes related to Astrocytoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:00828311.4S100B, EGFR, PCNA, PTEN, TP53
2positive regulation of cell proliferationGO:00828411.4S100B, TNC, EGFR, CDK4, PTEN
3central nervous system developmentGO:00741711.3TP53, PTEN, NES, S100B
4long-term synaptic potentiationGO:06029111.2PTEN, GFAP, S100B
5positive regulation of cell sizeGO:04579310.9TP73, CDK4
6negative regulation of cell sizeGO:04579210.9TSC1, PTEN
7positive regulation of apoptotic processGO:04306510.8TP53, TP73, CDK4, S100B
8positive regulation of oligodendrocyte differentiationGO:04871410.8OLIG2, TP73
9DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.8TP53, TP73
10mitotic G1 DNA damage checkpointGO:03157110.7TP73, TP53

Molecular functions related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.4TP53, TP73, PCNA, SYP, EGFR, S100B

Products for genes affiliated with Astrocytoma

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Astrocytoma

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet