Astrocytoma malady

Disease Ontology: A malignant glioma that is has material basis in astocyte cells, a type of glial cell, located in the cerebrum.⁶

MalaCards: Astrocytoma, also known as cerebral astrocytoma, is related to carcinoma and neuronitis. An important gene associated with Astrocytoma is TRIM47 (tripartite motif containing 47), and among its related pathways are ERK Signaling and cAMP Pathway. The drugs cisplatin and cisplatin pwdr [va product] and the compounds atp and genistein have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and cortex, and related mouse phenotypes are behavior/neurological and nervous system.

Wikipedia: Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,...⁴⁴ more...

Aliases & Descriptions:

astrocytoma 6 8 32 43 cerebral astrocytoma 6 8 43 astrocytoma, no icd-o subtype (morphologic abnormality) 6 astrocytoma of brain (disorder) 6

astrocytoma of cerebrum 6 astrocytic tumor 6 astroglioma 6

Diseases related to astrocytoma by text searches and GeneDecks gene sharing:

(show top 50)    (show all 839)

id	Related Disease	Score	Top Affiliating Genes
1	carcinoma	100.6	PIK3CA, PIK3R1, PIK3CG, LRP1, SH3GL2, KLF6
2	neuronitis	87.7	PIK3CA, PIK3R1, PIK3CG, LRP1, SH3GL2, KLF6
3	leukemia	80.9	PIK3CA, PIK3R1, PIK3CG, LRP1, SH3GL2, KLF6
4	melanoma	79.3	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
5	neuroblastoma	78.4	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF16, KLF6
6	colorectal cancer	76.5	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
7	thyroiditis	75.6	PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1, RECK
8	hypoxia	69.4	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF16, RECK
9	cerebritis	69.4	PIK3R1, PIK3CG, LRP1, KLF6, NCAM1, RELA
10	colon cancer	69.1	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, PDE2A
11	retinitis	64.3	PIK3CA, PIK3CG, LRP1, KLF6, PDE2A, PDE3B
12	adenoma	63.3	PIK3CA, NCAM1, RECK, RET, CNR1, KIT
13	cholesterol	59.3	PIK3CA, PIK3R1, PIK3CG, LRP1, PDE3B, RECK
14	meningioma	56.1	PIK3CG, NCAM1, RET, CNTNAP1, PCNA, RB1
15	malignant glioma	55.7	PIK3CA, PIK3CG, RECK, KIT, VTN, PCNA
16	prostatitis	54.1	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
17	anaplastic astrocytoma	53.7	PCNA, RB1, BSG, VEGFA, RAB3IP, BLZF1
18	retinoblastoma	53.4	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, PDE3B
19	pilocytic astrocytoma	52.4	KIAA1549, BRAF, VEGFA, RANBP9, RAB19, RAB3IP
20	medulloblastoma	52.2	PIK3CA, PIK3R1, PIK3CG, NCAM1, KIT, PCNA
21	pancreatitis	51.7	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
22	glioblastoma	51.6	PIK3CA, PIK3CG, KLF6, RB1, SETD2, BSG
23	oligodendroglioma	49.2	PIK3CA, KLF6, NCAM1, PDE3B, PCNA, RB1
24	adenocarcinoma	48.6	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
25	obesity	47.7	PIK3CA, PIK3R1, PIK3CG, LRP1, PDE3B, RECK
26	hepatitis	47.0	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
27	tuberculosis	45.4	PIK3CG, PDE3B, RELA, RELB, RB1, VIM
28	choroiditis	42.2	PIK3CG, NCAM1, VTN, PCNA, RBL1, SETD2
29	tuberous sclerosis	42.1	PIK3CA, PIK3R1, PIK3CG, PCNA, VIM, VHL
30	gastric cancer	41.6	PIK3CA, PIK3R1, PIK3CG, KLF6, RECK, RELA
31	hepatocellular carcinoma	41.6	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
32	diffuse astrocytoma	41.2	PCNA, BRAF, MYT1L, BIN1, LGALS3, LDHA
33	esophagitis	41.2	PIK3CA, PIK3CG, KLF6, NCAM1, RECK, RELA
34	ependymoma	41.2	NCAM1, VTN, RB1, VIM, BRCA2, VEGFA
35	breast carcinoma	39.9	PIK3CA, PIK3R1, PIK3CG, LRP1, SH3GL2, RECK
36	sarcoma	39.6	PIK3CA, PIK3R1, PIK3CG, NCAM1, RECK, RELA
37	gonococcal synovitis	39.3	PIK3CA, PIK3R1, PIK3CG, LRP1, NCAM1, PDE3B
38	wilms tumor	39.0	NCAM1, RET, PCNA, SETD2, VIM, BRCA1
39	papilloma	38.6	RET, PCNA, RB1, RBL1, VIM, BRAF
40	pertussis	38.4	PIK3CG, RELA, CNR1, CNR2, LPAR1, LPAR2
41	cervicitis	38.4	PIK3CA, PIK3CG, RECK, RELA, RET, CNR1
42	alzheimer's disease	38.1	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, NCAM1
43	subependymal giant cell astrocytoma	37.9	SGCA, VIM, MTOR, S100B, FABP7, MAP2
44	neuroectodermal tumors	37.7	NCAM1, KIT, RB1, VIM, MYC, RAF1
45	fibrosis	37.1	PIK3CA, PIK3CG, LRP1, KLF6, RECK, RELA
46	hemangioma	37.0	RELA, RET, RB1, SETD2, VHL, VEGFA
47	pleomorphic adenoma	36.9	PCNA, VIM, BRCA1, MYC, BMP6, LIFR
48	lung carcinoma	36.8	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RECK
49	arthritis	36.5	PIK3CG, LRP1, RECK, RELA, RELB, CNR1
50	ovarian carcinoma	36.2	PIK3CA, PIK3CG, RECK, RELA, KIT, VTN

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 cisplatin, cisplatin pwdr [va product], temozolomide

MalaCards organs/tissues related to astrocytoma:

²²

FMA organs/tissues related to astrocytoma:

¹¹

MGI Mouse Phenotypes related to astrocytoma:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological phenotype	MP:0005386	INF	PIK3CA, LRP1, NCAM1, RELB, CNR1,
2	nervous system phenotype	MP:0003631	INF	LRP1, RECK, RELA, CNR1, , KIT
3	growth/size phenotype	MP:0005378	INF	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, PDE3B
4	homeostasis/metabolism phenotype	MP:0005376	40.1	PIK3CA, PIK3R1, PIK3CG, LRP1, PDE3B, RELA
5	cardiovascular system phenotype	MP:0005385	31.6	PIK3CA, PIK3R1, PIK3CG, LRP1, KLF6, RECK
6	tumorigenesis	MP:0002006	23.0	PIK3CA, PIK3R1, RET, KIT, RB1, RBL1
7	digestive/alimentary phenotype	MP:0005381	22.8	RELB, RET, KIT, RB1, RBL1, BRAF
8	normal phenotype	MP:0002873	22.7	PIK3R1, LRP1, RELA, RET, VTN, RBL1
9	embryogenesis phenotype	MP:0005380	22.3	PIK3CA, KLF6, RECK, RET, KIT, RBL1
10	no phenotypic analysis	MP:0003012	17.8	PIK3R1, RET, CNR1, PCNA, RB1, RBL1
11	limbs/digits/tail phenotype	MP:0005371	16.4	RECK, RELA, RELB, RET, KIT, RB1
12	hearing/vestibular/ear phenotype	MP:0005377	16.3	KIT, RB1, MYC, BMP4, RARA, RARB
13	endocrine/exocrine gland phenotype	MP:0005379	15.9	RELB, RET, RBL1, SERPINE2, BRCA1, BRCA2
14	craniofacial phenotype	MP:0005382	15.7	KIT, RBL1, LPAR1, BMI1, BMP4, RASA1
15	pigmentation phenotype	MP:0001186	15.0	PDE3B, KIT, BTD, RB1, BRAF, BRCA1
16	adipose tissue phenotype	MP:0005375	14.9	PIK3CA, PIK3R1, LRP1, PDE3B, CNR1, RB1
17	liver/biliary system phenotype	MP:0005370	14.7	KLF6, RECK, RELB, KIT, RBL1, SERPINA6
18	other phenotype	MP:0005395	13.4	RECK, RELB, CNR1, RARA, RARB, KDR
19	respiratory system phenotype	MP:0005388	13.1	RELB, RET, BRCA1, LPAR2, RAD50, PARK2
20	reproductive system phenotype	MP:0005389	INF	PIK3CA, KLF6, RET, , RBL1, SERPINE2
21	vision/eye phenotype	MP:0005391	INF	PIK3CA, NCAM1, RELA, , KIT, BTD
22	skeleton phenotype	MP:0005390	INF	PIK3CG, LRP1, RECK, RELA, CNR1, KIT
23	immune system phenotype	MP:0005387	INF	LRP1, RELB, SGCA, CNR2, KIT, RBL1
24	renal/urinary system phenotype	MP:0005367	INF	RET, KIT, BTD, SERPINA6, BRAF, BRCA1
25	integument phenotype	MP:0010771	INF	PIK3CG, KLF6, PDE3B, RECK, RELA, RELB
26	mortality/aging	MP:0010768	INF	PIK3CA, LRP1, KLF6, NCAM1, PDE2A, RECK
27	hematopoietic system phenotype	MP:0005397	INF	KLF6, KIT, PCNA, RBL1, BRAF, BRCA1
28	muscle phenotype	MP:0005369	INF	PIK3CA, PIK3R1, PIK3CG, LRP1, RELA, RELB
29	cellular phenotype	MP:0005384	INF	PIK3CA, PIK3R1, PIK3CG, KLF6, NCAM1, RELA

Articles related to astrocytoma:

(show top 50)    (show all 813)

id	Title	Authors	Year	Affiliating Genes
1	Identification and characterization of estrogen recep tor-related receptor alpha and gamma in human glioma and astrocytoma cells. (19822186)	Gandhari M.K.... Wainer I.W.	2010	ESRRA, ESRRB, ESRRG
2	Overexpression of c-erbB2 is a negative prognostic fa ctor in anaplastic astrocytomas. (20331873)	Gulati S.... Torp S.H.	2010	ERBB2, EGFR
3	Involvement of aquaporin in thromboxane A2 receptor-m ediated, G 12/13/RhoA/NHE-sensitive cell swelling in 1321N1 human astrocytoma c ells. (19772916)	Saito M.... Nakahata N.	2010	RHOA, AQP4, AQP1
4	Combined molecular analysis of BRAF and IDH1 distingu ishes pilocytic astrocytoma from diffuse astrocytoma. (19543740)	Korshunov A.... Hartmann C.	2009	BRAF, IDH1
5	Influence of imatinib mesylate on radiosensitivity of astrocytoma cells. (20032406)	Ranza E.... Nano R.	2009	PDGFRB
6	Myc down-regulation affects cyclin D1/cdk4 activity and induces apoptosis via Smac/Diablo pathway in an astrocytoma cell line. (19143767)	Amendola D.... Bucci B.	2009	CDK4, MYC, CCND1
7	Activation of Wnt/beta-catenin/Tcf signaling pathway in human astrocytomas. (19576519)	Sareddy G.R.... Babu P.P.	2009	JUN, TCF7L2, DVL1
8	Loss of prostaglandin D2 synthase: a key molecular event in the transition of a low-grade astrocytoma to an anaplastic astrocytoma. (18852145)	Payne C.A.... McDonald K.L.	2008	PTGDS
9	Activation of the human FPRL-1 receptor promotes Ca2+ mobilization in U87 astrocytoma cells. (17703360)	Kwan D.H.... Wong Y.H.	2008	GNAI1, FPR2
10	Prognostic significance of co-overexpression of the EGFR/IGFBP-2/HIF-2A genes in astrocytomas. (17285230)	Scrideli C.A.... Tone L.G.	2007	EGFR, EPAS1, IGFBP2
11	Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)	Maes L.... De Ridder L.	2007	TERT
12	Cytoplasmic, but not nuclear, p16 expression may signal poor prognosis in high-grade astrocytomas. (16614947)	Arifin M.T.... Kurisu K.	2006	CDKN2A
13	Gemistocytic astrocytomas: histomorphology, proliferative potential and genetic alterations--a study of 32 cases. (16614946)	Avninder S.... Sarkar C.	2006	EGFR
14	A dyad symmetry element in the fibroblast growth factor-2 gene promoter with different levels of activity in astrocytoma and hepatocelluar carcinoma cell lines. (16739027)	Ueba T.... Hashimoto N.	2006	FGF2
15	Immunohistochemical evaluation of minichromosome maintenance protein 7 in astrocytoma grading. (17094475)	Facoetti A.... Nano R.	2006	MCM7
16	FAS associated phosphatase (FAP-1) blocks apoptosis of astrocytomas through dephosphorylation of FAS. (16187021)	Foehr E.D.... Urfer R.	2005	FAS, PTPN13
17	Localization of the endothelin system in human diffuse astrocytomas. (16007684)	Naidoo V.... Raidoo D.M.	2005	EDNRA, ECE1
18	Pathological and molecular progression of astrocytomas in a GFAP:12 V-Ha-Ras mouse astrocytoma model. (16127163)	Shannon P.... Guha A.	2005	EGFR, PTEN, VEGFA
19	Shc3 affects human high-grade astrocytomas survival. (15870690)	Magrassi L.... Cattaneo E.	2005	SHC3
20	Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. (16357147)	Woerner B.M.... Rubin J.B.	2005	CXCR4, CXCL12
21	Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma. (16098465)	Zhu Y.... Parada L.F.	2005	TP53, NF1
22	Effect of melatonin on temporal changes of reactive oxygen species and glutathione after MPP(+) treatment in human astrocytoma U373MG cells. (14962063)	Chuang J.I.... Chen T.H.	2004	CASP3, MAOB
23	Cyclooxygenase-2, Bcl-2, and chromosome 1p analysis in protoplasmic astrocytomas. (15017587)	Prayson R.A.	2004	PTGS2
24	Expression of pituitary tumor transforming gene (PTTG) and its binding protein in human astrocytes and astrocytoma cells: function and regulation of PTTG in U87 astrocytoma cells. (15178645)	Tfelt-Hansen J.... Chattopadhyay N.	2004	PPARG, TNF, PTTG1
25	Galectin-3 as an immunohistochemical tool to distinguish pilocytic astrocytomas from diffuse astrocytomas, and glioblastomas from anaplastic oligodendrogliomas. (15605987)	Neder L.... Zago M.A.	2004	LGALS3
26	Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): a study of histopathologic features, grading, an d outcome. (12023579)	Brat D.J.... Burger P.C.	2002	RPS27A
27	Expression of vascular endothelial growth factor (VEGF) and its two receptors in diffusely infiltrating astrocytomas and relationship to proliferative activity of tumor cells. (11908876)	Xiang F.... Fukuda T.	2001	FLT1, KDR, VEGFA
28	Serum deprivation and NGF induce and modulate voltage-gated Na(+) currents in human astrocytoma cell lines. (11284020)	Kraft R.... Patt S.	2001	NGF
29	Galectins are differentially expressed in supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas, and significantly modulate tumor astrocyte migration. (11145198)	Camby I.... Kiss R.	2001	LGALS3, LGALS1, LGALS8
30	Expression of the neural cell adhesion molecule in human astrocytomas (12536535)	Huang C.X.... Chen B.	2001	NCAM1, PCNA
31	Impaired RNA splicing of 5'-regulatory sequences of the astroglial glutamate transporter EAAT2 in human astrocytoma. (11606683)	Munch C.... Meyer T.	2001	SLC1A2
32	Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas. (11294925)	Li J.... Gutmann D.H.	2001	CDK4, EGFR, NF1
33	Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)	Cheng Y.... Poon W.S.	2000	CDK4, TP53, PTEN
34	Apoptosis induced by 2-chloro-adenosine and 2-chloro-2'-deoxy-adenosine in a human astrocytoma cell line: differential mechanisms and possible clinical relevance. (10797542)	Ceruti S.... Abbracchio M.P.	2000	ADK, DCK
35	Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. (11005256)	Lau N.... Guha A.	2000	NF1
36	Preferential inactivation of the p53 tumor suppressor pathway and lack of EGFR amplification distinguish de novo high grade pediatric astrocytomas from de novo adult astrocytomas. (10764044)	Sung T.... Newcomb E.W.	2000	EGFR, RB1, TP53
37	Astrocytoma cell interaction with elastin substrates: implications for astrocytoma invasive potential. (9890632)	Jung S.... Rutka J.T.	1999	GLB1
38	Extracellular calcium-sensing receptor induces cellular proliferation and activation of a nonselective cation channel in U373 human astrocytoma cells. (10642834)	Chattopadhyay N.... Brown E.M.	1999	CASR, NR1I3
39	Supratentorial pilocytic astrocytomas, astrocytomas, anaplastic astrocytomas and glioblastomas are characterized by a differential expression of S100 proteins. (9989446)	Camby I.... Decaestecker C.	1999	S100B, S100A4, S100A2
40	MIB-1 and p53 immunocytochemistry for differentiating pilocytic astrocytomas and astrocytomas from anaplastic astrocytomas and glioblastomas in children and young adults. (9839169)	Matsumoto T.... Sato K.	1998	TP53
41	The stimulation of glutamate uptake by the phorbol ester in rat cerebral cortex synaptosomes and cell line of human anaplastic astrocytoma BT-325 (11324578)	Zhu B.G.... Chen Y.Z.	1998	DYT10
42	Increased expression of low density lipoprotein receptor-related protein/alpha2-macroglobulin receptor in human malignant astrocytomas. (9205092)	Yamamoto M.... Tomonaga M.	1997	LRP1, PLAUR
43	Expression of vascular endothelial growth factor and its receptors in pilocytic astrocytoma. (9255258)	Leung S.Y.... Chung L.P.	1997	FLT1, VEGFA
44	PAX5 expression correlates with increasing malignancy in human astrocytomas. (9815975)	Stuart E.T.... Gruss P.	1995	PAX5
45	Hypothalamic astrocytoma presenting as obesity with hypogonadism (8367917)	Adingra-Groga N.... Bojanowski M.	1993	GFAP
46	IL1 and TNF alpha induce cGMP formation in C6 astrocytoma cells via the nitridergic pathway. (7683959)	Vigne P.... Frelin C.	1993	IL1A
47	Pleomorphic granular cell astrocytoma of the pineal g land. (1394046)	Snipes G.J.... Silverberg G.D.	1992	SAG
48	Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells. (1902475)	Malik R.K.... Blackshear P.J.	1991	EGF, FOS
49	Differential expression of ros oncogene in primary human astrocytomas and astrocytoma cell lines. (2185878)	Wu J.K.... Chikaraishi D.M.	1990	ROS1
50	PGJ2 and delta 12PGJ2 inhibit cell growth accompanied with inhibition of phosphoinositide turnover in human astrocytoma cells. (2177901)	Nakahata N.... Nakanishi H.	1990	ADCY10

Genes related to astrocytoma according to GeneCards:

(show top 50)    (show all 721)

id	Symbol	Description	Score	GeneCards Section Context
1	TRIM47	tripartite motif containing 47	11.0	Expressions, Publications, Aliases & Descriptions
2	GFAP	glial fibrillary acidic protein	11.0	Publications
3	MGMT	O-6-methylguanine-DNA methyltransferase	11.0	Publications
4	PTEN	phosphatase and tensin homolog	11.0	Publications, Functions
5	S100B	S100 calcium binding protein B	11.0	Publications
6	TNC	tenascin C	11.0	Publications
7	TP53	tumor protein p53	11.0	Publications
8	SYP	synaptophysin	11.0	Publications
9	CDK4	cyclin-dependent kinase 4	11.0	Publications, Functions
10	EGFR	epidermal growth factor receptor	11.0	Publications, Functions
11	NES	nestin	11.0	Publications
12	IGFBP2	insulin-like growth factor binding protein 2, 36kDa	11.0	Publications
13	LGALS3	lectin, galactoside-binding, soluble, 3	11.0	Publications
14	CDKN2A	cyclin-dependent kinase inhibitor 2A	11.0	Publications
15	PCNA	proliferating cell nuclear antigen	11.0	Publications
16	TP73	tumor protein p73	11.0	Publications
17	IDH1	isocitrate dehydrogenase 1 (NADP+), soluble	11.0	Publications
18	OLIG2	oligodendrocyte lineage transcription factor 2	11.0	Publications, Expressions
19	TSC1	tuberous sclerosis 1	11.0	Publications
20	APOD	apolipoprotein D	11.0	Publications
21	MKI67	antigen identified by monoclonal antibody Ki-67	11.0	Publications
22	PDGFRA	platelet-derived growth factor receptor, alpha polypeptide	11.0	Publications
23	PDGFRB	platelet-derived growth factor receptor, beta polypeptide	11.0	Publications
24	THBS1	thrombospondin 1	11.0	Publications
25	FLT1	fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)	11.0	Publications
26	OLIG1	oligodendrocyte transcription factor 1	11.0	Expressions, Publications
27	S100A6	S100 calcium binding protein A6	11.0	Publications
28	TIMP3	TIMP metallopeptidase inhibitor 3	11.0	Publications
29	BRAF	v-raf murine sarcoma viral oncogene homolog B1	11.0	Publications
30	BSG	basigin (Ok blood group)	11.0	Publications
31	CDKN2B	cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)	11.0	Publications
32	RB1	retinoblastoma 1	11.0	Publications
33	VEGFA	vascular endothelial growth factor A	11.0	Publications
34	S100A3	S100 calcium binding protein A3	11.0	Publications
35	S100A5	S100 calcium binding protein A5	11.0	Publications
36	DMBT1	deleted in malignant brain tumors 1	11.0	Publications
37	FSCN1	fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)	11.0	Publications
38	TSC2	tuberous sclerosis 2	11.0	Publications
39	ADM	adrenomedullin	11.0	Publications
40	CCNA2	cyclin A2	11.0	Publications
41	FGFR4	fibroblast growth factor receptor 4	11.0	Publications
42	PDGFA	platelet-derived growth factor alpha polypeptide	11.0	Publications
43	TUBG1	tubulin, gamma 1	11.0
44	ANXA2	annexin A2	11.0
45	CCNB1	cyclin B1	11.0	Publications
46	MAP2	microtubule-associated protein 2	11.0	Publications
47	MDM2	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	11.0	Publications, Functions
48	NF1	neurofibromin 1	11.0	Publications
49	CDH2	cadherin 2, type 1, N-cadherin (neuronal)	11.0	Publications
50	CDKN1A	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	11.0	Publications

Pathways related to astrocytoma according to GeneDecks:

(show top 50)    (show all 373)

id	Pathway	Score	Top Affiliating Genes
1	ERK Signaling36	16.5	PIK3R1, KIT, BRAF, VEGFB, MYC, BMP4
2	cAMP Pathway36	16.0	PIK3R1, PDE2A, PDE3B, KIT, BRAF, VEGFB
3	JAK-STAT Pathway36	15.6	PIK3R1, KIT, BRCA1, VEGFB, MYC, BMP4
4	Phospholipase-C Pathway36	15.3	KIT, VEGFB, BMP4, BMP6, RAP1A, RAF1
5	MAPK Family Pathway36	15.1	PIK3R1, BRAF, VEGFB, BMP4, BMP6, RAF1
6	Cellular Apoptosis Pathway36	15.0	PIK3R1, KIT, VEGFB, BMP4, BMP6, BIRC2
7	Transendothelial Migration of Leukocytes36	14.9	PIK3R1, VCAM1, RAP1A, RAC1, BCAR1, ITGA4
8	Glioma20	14.7	PIK3CA, PIK3R1, PIK3CG, RB1, BRAF, RAF1
9	Nanog in Mammalian ESC Pluripotency36	14.7	KIT, BRAF, VEGFB, BMP4, BMP6, RAF1
10	Cell Cycle / Checkpoint Control3	14.6	PCNA, RB1, BRCA1, BRCA2, RAD50, LATS1
11	Chemokine Signaling36	13.9	PIK3R1, BCAR1, JUN, FOS, GRB2, IL8
12	PPAR Pathway36	13.5	PIK3R1, KIT, VEGFB, BMP4, RAF1, ITGA4
13	IP3 Pathway36	13.4	PIK3R1, VEGFB, BMP4, BMP6, KDR, FYN
14	Cytoskeleton remodeling_FAK signaling41	13.3	PIK3CA, PIK3R1, VEGFA, RAP1A, RAF1, RAC1
15	G12-G13 in Cellular Signaling36	13.3	PIK3R1, RAF1, RAC1, RASA1, CHN2, CHUK
16	Transcription_P53 signaling pathway41	13.3	RELA, RELB, RB1, VEGFA, RANBP2, KDR
17	Bladder cancer20	13.3	RB1, BRAF, VEGFA, VEGFB, MYC, RAF1
18	FGF Pathway36	13.2	PIK3R1, RAF1, RAC1, RASA1, FGF1, FGF2
19	Toll-like receptor signaling pathway20	13.1	PIK3CA, PIK3R1, PIK3CG, RELA, RAC1, CHUK
20	Endometrial cancer20	13.1	PIK3CA, PIK3R1, PIK3CG, BRAF, MYC, RAF1
21	Development PDGF signaling via MAPK cascades10	13.0	PIK3CA, PIK3R1, RAF1, RAC1, JUN, GRB2
22	CCKBR-Gastrin Stimulated Signaling36	13.0	RAF1, BCAR1, JUN, FOS, GRB2, MAPK8
23	PDGF Pathway36	12.8	PIK3R1, RAF1, RAC1, RASA1, CHUK, JUN
24	Development_Thrombopoietin-regulated cell processes41	12.8	PIK3CA, PIK3R1, BRAF, MYC, RAP1A, RAF1
25	Development_VEGF-family signaling41	12.8	PIK3CA, PIK3R1, VTN, VEGFA, VEGFB, RAF1
26	Development_A2B receptor- action via G-protein alpha s41	12.7	PIK3CA, RELA, RELB, BRAF, RAP1A, CEBPB
27	Development_Endothelin-1/EDNRA signaling41	12.5	RAC1, GRB2, MAPK14, MAPK10, CCND1, GNAI1
28	Germ Cell-Sertoli Cell Junction Dynamics36	12.5	VCL, RAC1, BCAR1, AXIN1, JUP, CDH2
29	Development_EPO-induced MAPK pathway41	12.5	PIK3CG, KIT, RAP1A, RAF1, RAC1, JUN
30	Development HGF signaling pathway10	12.5	PIK3CA, PIK3R1, RAP1A, RAF1, RAC1, JUN
31	Renal cell carcinoma20	12.4	PIK3R1, VHL, RAP1A, RAF1, RAC1, JUN
32	Development_PDGF signaling via STATs and NF-kB41	12.4	PIK3CA, PIK3R1, RELA, RELB, MYC, CHUK
33	Ceramide Pathway36	12.4	PIK3R1, RAF1, JUN, JUND, FOS, FOSL1
34	Cell cycle_Regulation of G1/S transition (part 2)41	12.3	RELA, RB1, RBL1, CHUK, JUN, CDK6
35	Development A2A receptor signaling10	12.3	PIK3CA, RELA, RELB, BRAF, RAP1A, CHUK
36	Adherens junction20	12.3	VCL, RAC1, LEF1, FYN, IQGAP1, INSR
37	Natural killer cell mediated cytotoxicity20	12.2	PIK3CA, PIK3R1, PIK3CG, BRAF, RAF1, RAC1
38	PI3K Signaling in B-Lymphocyte36	12.2	PIK3R1, RAF1, RAC1, CHUK, FYN, JUN
39	Development A1 receptor signaling10	12.2	PIK3CG, RELA, RELB, RAF1, RAC1, CHUK
40	MIF Regulation of Innate Immune Cells36	12.0	BMP4, BMP6, BCL2, BAX, JUN, FOS
41	Immune response Oncostatin M signaling via MAPK in human cells10	11.8	RAF1, RAC1, LIFR, CEBPB, JUN, JUND
42	Transcription P53 signaling pathway10	11.8	RELA, RELB, VEGFA, RANBP2, CDK2, CDKN2A
43	Development_GDNF family signaling41	11.8	PIK3CA, PIK3R1, RELA, RELB, RET, RAF1
44	Apoptosis and survival TNFR1 signaling pathway10	11.7	RELA, RELB, BIRC2, BIRC3, CHUK, BAX
45	IL-6 Pathway36	11.5	PIK3R1, BRAF, BMP4, BMP6, RAF1, BAX
46	MIF Mediated Glucocorticoid Regulation36	11.2	BMP4, BMP6, BCL2, BAX, IL10, IL13
47	T cell receptor signaling pathway20	11.0	PIK3CA, PIK3R1, PIK3CG, RELA, RAF1, CHUK
48	Pancreatic cancer20	11.0	BRCA2, CDK6, E2F2
49	Immune response MIF-mediated glucocorticoid regulation10	10.7	RELA, RELB, VCAM1, CHUK, JUN, MMP1
50	Leishmaniasis20	10.6	RELA, JUN, ITGA4, ITGB1, FOS, IL10

Compounds related to astrocytoma according to GeneDecks:

(show top 50)    (show all 457)

id	Compound	Score	Top Affiliating Genes
1	atp32	26.8	PIK3CA, NCAM1, PDE3B, RECK, RET, KIT
2	genistein32 9 18 9	28.6	PIK3CA, PIK3R1, PIK3CG, RET, PCNA, RB1
3	progesterone32 42 9 18 9	29.1	PIK3CA, PIK3R1, NCAM1, KIT, PCNA, RB1
4	cholesterol32 9 18 9	26.6	PIK3CA, PIK3R1, LRP1, PDE3B, RECK, CNR2
5	paclitaxel32 34 9 9	25.7	PIK3CA, PIK3CG, KIT, PCNA, RB1, SETD2
6	heparin32 9 18 9	25.4	PIK3CA, PIK3CG, LRP1, NCAM1, RECK, VTN
7	forskolin32 42 9 9	24.4	PIK3R1, PDE3B, CNR2, VIM, BRAF, BMP4
8	gtp32	18.5	PIK3CA, PIK3R1, PDE2A, PDE3B, RECK, CNR2
9	glucose32	18.2	KIT, PC, BTD, SETD2, BRAF, VHL
10	gf 109203x32 42	17.8	PIK3CG, VEGFA, VCL, RAP1A, RAF1, CHRM3
11	prostacyclin32	16.0	PDE2A, PDE3B, VTN, SERPINE1, VEGFA, VCAM1
12	sucrose32 9 18 9	19.0	LRP1, RECK, BSG, VCL, RARA, BLZF1
13	threonine32	15.9	RET, LPAR3, RAP1A, RAF1, PARK2, BDKRB2
14	camptothecin32 42 9 9	18.8	PIK3CG, PCNA, RB1, SETD2, BRCA1, BRCA2
15	resveratrol32 9 18 9	18.6	PIK3CA, PIK3CG, PCNA, RB1, BSG, BRCA1
16	vitamin d32	15.3	LRP1, SERPINE1, VIM, BMP6, RARA, RARS
17	polysaccharide32	14.7	NCAM1, RECK, VTN, SERPINE2, SERPINA3, VCAM1
18	trastuzumab32 34 9 9	16.9	PIK3CA, PIK3R1, PIK3CG, KIT, RAF1, BIRC5
19	ganglioside32	13.8	NCAM1, VIM, BCAR1, BCR, LGALS1, CIITA
20	troglitazone32 42 9 9	16.8	PIK3CG, RB1, SERPINE1, VCAM1, BMP6, RARA
21	tetrodotoxin32	13.5	CNR1, SERPINE2, MME, GRP, APOE, MBP
22	histidine32	13.4	PDE3B, VHL, RARA, LGALS1, CIITA, S100B
23	crcs32	13.2	PIK3CA, RB1, BRAF, RASSF1, BIRC5, MSH2
24	docetaxel32 34 9 9	16.2	KIT, SETD2, BRCA1, BRCA2, VEGFA, MYC
25	verapamil32 34 9 18 9	17.1	LRP1, RECK, MYC, MVP, INSR, GSTP1
26	mitomycin c32	13.0	PCNA, RB1, BRCA1, BRCA2, VCAM1, BIRC5
27	tetrapeptide32	12.8	VTN, RB1, BIRC5, BCL2L1, XIAP, CDKN2A
28	pdtc32	12.8	PIK3CA, PIK3CG, SETD2, VCAM1, RAF1, BIRC3
29	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	12.5	PCNA, MYC, BCL2, BCL2L1, BAX, S100B
30	go 697632 42	13.3	PIK3CG, MMP2, IL8, MAPK8, MAPK3, MAPK14
31	palmitate32	12.1	PC, S100A6, FYN, IRS1, GRP, HSPG2
32	atorvastatin32 34 9 18 9	16.1	VEGFA, VCAM1, BMP6, RAC1, CHKA, CD59
33	cerivastatin32 9 9	14.1	SERPINE1, RAC1, MMP1, APOB, CCL2, CCL5
34	octreotide32 42 9 9	15.1	VEGFA, MME, MMP2, MKI67, INSR, GRP
35	bisindolylmaleimide32	12.1	RAF1, RAC1, S100B, FOS, GRP, MAPK3
36	eb 108932	11.9	PCNA, BCL2, BAX, CDK6, CDKN1A, CDK2
37	sorafenib32 9 9	13.9	RET, KIT, BRAF, VHL, VEGFA, RAF1
38	propranolol32 34 9 18 9	15.8	CDKN3, MME, MMP2, GRP, APP, CCL5
39	piceatannol32 42 9 9	14.6	PIK3CG, RAC1, CHUK, FYN, MAPK8, MAPK3
40	acetaminophen32 34 9 18 9	15.5	PCNA, NAT2, MYC, BCL2L1, MMP3, FAAH
41	ns 39832 42	12.5	PIK3CG, PCNA, CDKN1B, MMP1, FGF2, IL1A
42	raloxifene32 9 9	13.5	SERPINE1, PAX5, JUN, CD36, CDKN1B, CCL2
43	fludarabine32 9 9	13.4	BIRC2, BIRC3, BIRC5, BCL2, BCL2L1, BAX
44	cyclophosphamide32 34 9 9	14.4	MVP, ITGA4, CYP2C8, TAC1, DCK
45	4-hydroxynonenal32 18	12.4	MYC, CHKA, CHUK, BAX, JUN, CDK2
46	methylcellulose32	11.3	KIT, VCL, CD59, FGF2, IL1A, IL3
47	ivig32	11.2	SAG, IL1RAPL2, IL3, FASLG, MBP, CCL4
48	chloroquine32 34 9 9	13.9	KIT, VTN, BRCA1, BMP6, RAF1, CIITA
49	il 1032	8.9	BMP6, LBP, IL10, IL13, IL1A, IL1B
50	potassium32 9 18 9	INF	PIK3CA, NCAM1, PDE3B, , VTN, BRAF

Cellular components related to astrocytoma according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	PIK3CG, LRP1, , KLF6, PDE2A, RELA
2	nucleus	GO:005634	30.7	LRP1, KLF16, KLF6, PDE2A, RELA, RELB
3	extracellular region	GO:005576	20.1	NCAM1, CNTN4, VTN, SERPINE2, SERPINE1, SERPINA3
4	extracellular space	GO:005615	17.6	KIT, VTN, BTD, SERPINE1, VEGFA, VEGFB
5	nucleoplasm	GO:005654	17.4	RELA, PCNA, RB1, RBL1, BRCA1, BRCA2
6	perinuclear region of cytoplasm	GO:048471	15.0	PDE2A, PARK2, S100A4, S100A6, S100B, AXIN1
7	cell surface	GO:009986	14.6	NCAM1, VEGFA, LPAR1, LPAR2, VCAM1, RARA
8	basolateral plasma membrane	GO:016323	13.7	CHRM3, P2RY1, P2RY2, P2RY4, P2RY6, ATP7A
9	neuronal cell body	GO:043025	12.5	SERPINE2, MTOR, LAMP1, S100B, ATP7A, CDK5
10	protein complex	GO:043234	12.2	BRCA1, BRCA2, VCL, MYC, S100A1, CDKN2A
11	platelet alpha granule lumen	GO:031093	11.8	SERPINE1, VEGFA, VEGFB, FN1, FIGF, APP
12	external side of plasma membrane	GO:009897	11.6	NCAM1, KIT, VCAM1, KDR, LAMP1, CD36
13	cytosol	GO:005829	INF	PIK3CA, PIK3R1, PIK3CG, , PDE2A, PDE3B
14	plasma membrane	GO:005886	INF	PIK3R1, PIK3CG, , NCAM1, PDE2A, RECK
15	integral to plasma membrane	GO:005887	INF	LRP1, RET, CNR1, CNR2, , LPAR1

Biological processes related to astrocytoma according to GeneDecks:

(show top 50)    (show all 74)

id	Name	GO ID	Score	Top Affiliating Genes
1	signal transduction	GO:007165	INF	, RET, , KIT, NAMPT, RAP1A
2	axon guidance	GO:007411	INF	, NCAM1, CNTN4, , RANBP9, RAF1
3	blood coagulation	GO:007596	18.4	PIK3CA, PIK3R1, PIK3CG, PDE2A, PDE3B, SERPINE2
4	apoptotic process	GO:006915	17.4	VIM, BRCA1, RAF1, RAC1, BIRC2, BIRC3
5	positive regulation of cell proliferation	GO:008284	16.7	KIT, NAMPT, VEGFA, MYC, RARA, LIFR
6	negative regulation of cell proliferation	GO:008285	16.6	SERPINE2, VHL, BMP4, RARB, RAF1, BDKRB2
7	positive regulation of transcription from RNA polymerase II promoter	GO:045944	15.9	KLF6, RELA, RB1, RBL1, SERPINE1, BRCA1
8	cell proliferation	GO:008283	15.7	PCNA, RAF1, BLZF1, BIN1, BCAR1, BCL2L1
9	negative regulation of apoptotic process	GO:043066	15.3	PIK3CG, RELA, SERPINE1, BRAF, VEGFA, MYC
10	angiogenesis	GO:001525	15.0	PIK3CA, PIK3CG, PDE3B, SETD2, SERPINE1, VEGFA
11	platelet activation	GO:030168	14.8	PIK3CA, PIK3R1, PIK3CG, SERPINE1, VEGFA, VEGFB
12	inflammatory response	GO:006954	14.1	PIK3CG, RELA, CNR2, KIT, SERPINA3, BMP6
13	positive regulation of transcription, DNA-dependent	GO:045893	13.9	KLF6, RELA, RET, RB1, BRCA1, BRCA2
14	fibroblast growth factor receptor signaling pathway	GO:008543	13.8	PIK3CA, PIK3R1, BRAF, RAF1, CHUK, MTOR
15	response to lipopolysaccharide	GO:032496	13.7	CNR1, CNR2, LBP, CEBPB, JUN, MMP9
16	positive regulation of ERK1 and ERK2 cascade	GO:070374	13.7	BRAF, VEGFB, BMP4, KDR, CHI3L1, P2RY1
17	positive regulation of angiogenesis	GO:045766	13.5	SERPINE1, VEGFA, KDR, CHI3L1, MMP9, FLT1
18	elevation of cytosolic calcium ion concentration	GO:007204	13.5	LPAR1, LPAR2, LPAR3, BDKRB2, P2RY1, P2RY2
19	Ras protein signal transduction	GO:007265	13.4	RB1, RAF1, RASSF1, CDKN1A, CDK2, CDKN2A
20	response to drug	GO:042493	13.3	MYC, PARK7, BDKRB2, BCL2, LGALS1, MVP
21	virus-host interaction	GO:019048	13.3	PIK3R1, RELA, RB1, RBL1, VIM, VCAM1
22	cell surface receptor signaling pathway	GO:007166	13.3	BSG, LIFR, BIRC2, BIRC3, BDKRB2, SAG
23	aging	GO:007568	13.3	CNR1, VCAM1, P2RY1, P2RY2, JUN, GSN
24	protein autophosphorylation	GO:046777	13.3	KIT, KDR, MTOR, AURKB, ATM, FYN
25	cell cycle arrest	GO:007050	13.2	RB1, MYC, RASSF1, MSH2, ATM, CDK6
26	positive regulation of apoptotic process	GO:043065	13.1	CNR1, LPAR1, BMP4, RARB, KCNMA1, BAX
27	cell-cell signaling	GO:007267	13.1	NAMPT, INHA, FGFR2, MERTK, GRB2, IL10
28	response to wounding	GO:009611	13.1	RAC1, PAX6, ITGB4, FN1, MET, MDK
29	anti-apoptosis	GO:006916	13.1	PIK3CA, RELA, BRAF, VHL, VEGFB, BIRC2
30	insulin receptor signaling pathway	GO:008286	13.0	PIK3CA, PIK3R1, PDE3B, NAMPT, RAF1, BCAR1
31	leukocyte migration	GO:050900	13.0	PIK3CA, PIK3R1, BSG, ATP1B2, FYN, ITGA4
32	negative regulation of neuron apoptotic process	GO:043524	13.0	BRAF, VEGFB, RASA1, PARK7, PARK2, BCL2
33	phosphatidylinositol-mediated signaling	GO:048015	12.9	PIK3CA, PIK3R1, PCNA, CHUK, MTOR, CDKN1B
34	negative regulation of transcription from RNA polymerase II promoter	GO:000122	12.9	PDE2A, VHL, MYC, BMI1, BMP4, RARB
35	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	12.9	KIT, KDR, FLT1, FGFR1, ANGPT1, CCL5
36	positive regulation of cell migration	GO:030335	12.7	RET, VEGFA, KDR, BCAR1, LEF1, CDH13
37	positive regulation of MAPK cascade	GO:043410	12.6	KIT, LPAR1, LPAR2, LPAR3, KDR, CD36
38	positive regulation of fibroblast proliferation	GO:048146	12.5	MYC, BMI1, S100A6, JUN, CDK6, CDKN1A
39	response to organic cyclic compound	GO:014070	12.5	BMP4, LEF1, MSH2, JUN, CDKN1A, FOSL1
40	positive regulation of protein phosphorylation	GO:001934	12.5	VEGFA, BMP4, MTOR, P2RY1, AXIN1, INSR
41	platelet degranulation	GO:002576	12.2	SERPINE1, VEGFA, VEGFB, VCL, LAMP2, CD36
42	response to mechanical stimulus	GO:009612	12.1	BMP4, CHI3L1, P2RY1, JUN, MMP9, FOSL1
43	activation of MAPK activity	GO:000187	11.8	KIT, LPAR1, LPAR2, LPAR3, INSR, FGF2
44	activation of MAPKK activity	GO:000186	11.4	BMP4, RAF1, F2R, NTRK1, NRAS, PLCG1
45	response to ethanol	GO:045471	11.3	CNR1, BCL2, FYN, MMP9, INSR, MGMT
46	response to glucocorticoid stimulus	GO:051384	11.2	SERPINE1, INSR, IL10, IL1B, IL6, FAS
47	MAPK cascade	GO:000165	11.1	RET, MYC, RAF1, FGFR1, MEN1, IL1B
48	nerve growth factor receptor signaling pathway	GO:048011	INF	PIK3CA, PIK3R1, , RELA, BRAF, RAP1A
49	response to hypoxia	GO:001666	INF	VEGFA, VCAM1, RAF1, BCL2, KCNMA1, ATM
50	epidermal growth factor receptor signaling pathway	GO:007173	INF	PIK3CA, PIK3R1, , RAF1, BCAR1, CHUK

Molecular functions related to astrocytoma according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	APOB, MEN1, MELK, FGFR2, FGFR1, FGF2
2	ATP binding	GO:005524	18.1	TPX2, MAPK10, MAPK14, MAPK3, MAPK8, MCM7
3	protein homodimerization activity	GO:042803	15.9	TOP2A, SRGAP2, OLIG2, PTGS2, TERT, TERF1
4	protein kinase binding	GO:019901	14.5	GATA6, NPM1, PRKCE, DCX, STAT3, TCF7L2
5	enzyme binding	GO:019899	13.1	TP53, BLZF1, RAC1, RARA, RANBP9, VHL
6	protein heterodimerization activity	GO:046982	13.1	VEGFA, BRAF, NPM1, PML, TAP1, TGFB2
7	transcription factor binding	GO:008134	12.5	STAT3, TCF7L2, HIF1A, NFKBIA, SP1, DDIT3
8	growth factor activity	GO:008083	11.6	GDNF, NGF, NRG1, PTN, IGF1, GPI
9	protein tyrosine kinase activity	GO:004713	11.6	ERBB3, ERBB4, ERBB2, TEK, PTK2B, SRC
10	transmembrane receptor protein tyrosine kinase activity	GO:004714	11.6	NTRK1, NTRK3, PDGFRA, EGFR, ROS1, EPHA2
11	cytokine activity	GO:005125	10.9	NRG1, SPP1, TNFSF10, TNF, IFNG, IFNB1
12	identical protein binding	GO:042802	INF	PRDX1, GLUL, CASP8, HSP90AA1, IGF1R, FAS
13	receptor binding	GO:005102	INF	EDN3, LTA, PDGFRB, NOS2, CRAT, NRG1