MCID: AST007
MIFTS: 71

Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Astrocytoma

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9Disease Ontology, 66Wikipedia, 34MalaCards
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Disease Ontology:9 A malignant glioma that is has material basis in astocyte cells, a type of glial cell, located in the cerebrum.

MalaCards: Astrocytoma, also known as cerebral astrocytoma, is related to subependymal giant cell astrocytoma and pilocytic astrocytoma. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Advanced glycosylation endproduct receptor signaling and Inhibition of Ribosome Biogenesis by p14(ARF). The drugs cisplatin and temozolomide and the compounds reticulin and bcnu have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and spinal cord, and related mouse phenotypes are pigmentation and normal.

Wikipedia:66 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Aliases & Classifications for Astrocytoma

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Sources:
9Disease Ontology, 46Novoseek, 63UMLS, 36MeSH, 59SNOMED-CT, 41NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

astrocytoma 9 46 63
cerebral astrocytoma 9 63
astrocytoma, no icd-o subtype 9
astrocytoma of cerebrum 9
astrocytoma of brain 9
astrocytic tumor 9
astroglioma 9


External Ids:

Disease Ontology9 DOID:3069
MeSH36 D001254

Related Diseases for Astrocytoma

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Sources:
18GeneCards, 19GeneDecks
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Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 304)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.5S100B, SYP
2pilocytic astrocytoma31.5CDK4, S100B, OLIG2, SYP, LGALS3, NES
3tuberous sclerosis31.3S100B, SYP, NES, PTEN, GFAP
4anaplastic astrocytoma31.2EGFR, CDK4, CDKN2A, OLIG2, PCNA, LGALS3
5juvenile pilocytic astrocytoma31.2TNC
6gemistocytic astrocytoma30.9S100B, PTEN, GFAP
7glioblastoma multiforme30.9EGFR, CDK4, CDKN2A, NES, TP53, PTEN
8neuroblastoma30.8SYP, TP53
9medulloblastoma30.7CDK4, S100B, SYP, NES, TP73, TP53
10meningioma30.7S100B, PCNA, SYP, TP73, PTEN, TNC
11oligoastrocytoma30.7GFAP, MGMT
12oligodendroglioma30.6EGFR, CDK4, CDKN2A, OLIG2, PCNA, SYP
13ependymoma30.6EGFR, S100B, SYP, NES, TP73, GFAP
14ganglioglioma30.5S100B, SYP, GFAP
15turcot syndrome30.4PTEN
16dysembryoplastic neuroepithelial tumor30.3KIAA1549, OLIG2, SYP
17gliosarcoma30.3CDK4, PTEN, GFAP
18anaplastic oligodendroglioma30.2EGFR, CDK4, CDKN2A, OLIG2, LGALS3, PTEN
19retinoblastoma30.2EGFR, CDK4, CDKN2A, PCNA, SYP, TP73
20leukemia30.2CDK4, CDKN2A, OLIG2, NES, TP73, TP53
21malignant glioma30.1EGFR, CDK4, CDKN2A, KIAA1549, OLIG2, PCNA
22gangliocytoma30.1SYP, PTEN
23giant cell glioblastoma30.1EGFR, PTEN, GFAP
24central neurocytoma30.1OLIG2, SYP, GFAP
25hemangioblastoma30.1S100B, SYP, NES, GFAP
26adenoma30.1CDK4, CDKN2A, PCNA, SYP, LGALS3, NES
27colon cancer30.0EGFR, CDK4, LGALS3, TP73, TP53, IGFBP2
28pituitary adenoma30.0CDK4, PCNA, SYP, LGALS3, NES, TP73
29gliomatosis cerebri29.9PTEN, GFAP
30myxopapillary ependymoma29.9S100B, GFAP
31pineoblastoma29.9SYP, GFAP
32choroid plexus carcinoma29.9S100B, GFAP
33adenocarcinoma29.9EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
34li-fraumeni syndrome29.9CDKN2A, TP53
35brain cancer29.9EGFR, MGMT
36chordoma29.9S100B, LGALS3, GFAP
37neurilemmoma29.9S100B, NES, GFAP
38xeroderma pigmentosum29.9PCNA, TP53, MGMT
39pleomorphic adenoma29.8S100B, PCNA, TNC, GFAP
40neurofibroma29.8S100B, SYP, TP73, TNC
41b-cell lymphomas29.8CDK4, CDKN2A, TP53, MGMT
42breast cancer29.8EGFR, CDK4, TNC
43papilloma29.8CDKN2A, PCNA, TP73, TP53
44melanoma29.8CDK4, CDKN2A, S100B, PCNA, LGALS3, NES
45osteosarcoma29.8CDK4, CDKN2A, TP73, TP53
46prostate cancer29.7EGFR, CDK4, PCNA, LGALS3, NES, TP73
47colorectal cancer29.7EGFR, CDKN2A, PCNA, LGALS3, TP73, TP53
48cerebellar astrocytoma10.8
49pilomyxoid astrocytoma10.7
50diffuse astrocytoma10.7

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Symptoms for Astrocytoma

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Drugs & Therapeutics for Astrocytoma

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Search CenterWatch for Astrocytoma

Inferred drug relations via UMLS63/NDF-RT42:

Genetic Tests for Astrocytoma

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Anatomical Context for Astrocytoma

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Sources:
34MalaCards, 15FMA
See all sources

MalaCards organs/tissues related to Astrocytoma:

34
Brain, Spinal cord, Endothelial, Cerebellum, Pituitary, Pineal, Cortex, Temporal lobe, Breast, Thyroid, Monocytes, Testes, Ovary, Colon, Eye, T cells, Retina, Hypothalamus, Lung, Testis, Tongue, Bone, Medulla oblongata, Bone marrow, Prefrontal cortex, B cells, Myeloid, Prostate, Liver, Skin

FMA organs/tissues related to Astrocytoma:

15
The cerebrum

Animal Models for Astrocytoma or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Astrocytoma:

38 (show all 25)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00011869.7EGFR, CDKN2A, TP53, PTEN
2MP:00028739.2IGFBP2, GFAP, TNC, PTEN, TP53, SYP
3MP:00107719.2PTEN, TP53, LGALS3, S100B, CDKN2A, CDK4
4MP:00053699.2GFAP, PTEN, TP53, OLIG2, CDKN2A, CDK4
5MP:00053819.2GFAP, PTEN, TP53, TP73, LGALS3, CDKN2A
6MP:00053709.2IGFBP2, PTEN, TP53, CDKN2A, CDK4, EGFR
7MP:00053889.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
8MP:00020069.1MGMT, PTEN, TP53, TP73, OLIG2, CDKN2A
9MP:00053679.1IGFBP2, PTEN, TP53, LGALS3, CDK4, EGFR
10MP:00053809.1PTEN, TP53, TP73, NES, CDKN2A, CDK4
11MP:00053919.1GFAP, PTEN, TP53, TP73, OLIG2, CDKN2A
12MP:00030129.1MGMT, TP53, SYP, PCNA, NRN1, OLIG2
13MP:00053909.1PTEN, TP53, TP73, LGALS3, OLIG2, CDKN2A
14MP:00053799.1MGMT, PTEN, TP53, TP73, PCNA, CDKN2A
15MP:00053859.0IGFBP2, GFAP, PTEN, TP53, TP73, LGALS3
16MP:00053759.0PTEN, TP53, PCNA, OLIG2, EGFR
17MP:00053899.0PTEN, TP53, TP73, LGALS3, PCNA, CDKN2A
18MP:00053868.7GFAP, TNC, PTEN, TP53, TP73, NES
19MP:00053768.6TNC, GFAP, IDH1, MGMT, PTEN, TP53
20MP:00053848.6TP73, TP53, PTEN, GFAP, NES, LGALS3
21MP:00053978.5IGFBP2, IDH1, PTEN, TP53, TP73, LGALS3
22MP:00053788.4GFAP, PTEN, TP53, TP73, NES, PCNA
23MP:00053878.4PTEN, GFAP, IDH1, IGFBP2, TP53, TP73
24MP:00036318.2EGFR, GFAP, TNC, PTEN, TP53, TP73
25MP:00107688.2TP73, TP53, PTEN, GFAP, MGMT, NES

Publications for Astrocytoma

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Sources:
53PubMed
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Articles related to Astrocytoma:

(show top 50)    (show all 1865)
idTitleAuthorsYear
1
The genetic landscape of anaplastic astrocytoma. (24140581)
2013
2
Transformation of adult cerebellar pilocytic astrocytoma to glioblastoma. (23884731)
2013
3
Correlation of aquaporin-1 water channel protein expression with tumor angiogenesis in human astrocytoma. (23393355)
2013
4
Molecular interactions of ErbB1 (EGFR) and integrin-I^1 in astrocytoma frozen sections predict clinical outcome and correlate with Akt-mediated in vitro radioresistance. (23595626)
2013
5
Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma. (22825389)
2012
6
Cerebellar metastasis from serous adenocarcinoma of the ovary mimicking pilocytic astrocytoma. (23293670)
2012
7
Expression of pERK and pAKT in pediatric high grade astrocytomas: correlation with YKL40 and prognostic significance. (21978279)
2012
8
I^-Catenin signaling initiates the activation of astrocytes and its dysregulation contributes to the pathogenesis of astrocytomas. (22505738)
2012
9
Vascular endothelial growth factor receptor 2 (VEGFR-2) signalling activity in paediatric pilocytic astrocytoma is restricted to tumour endothelial cells. (21208252)
2011
10
Intracranial metastasis of spinal intramedullary anaplastic astrocytoma. (22347337)
2011
11
Analysis of PIK3CA and B-RAF gene mutations in human astrocytomas: association with activation of ERK and AKT. (20569675)
2010
12
Lipoxin A4 inhibits IL-1beta-induced IL-8 and ICAM-1 expression in 1321N1 human astrocytoma cells. (19357230)
2009
13
Analysis of interleukin (IL)-8 expression in human astrocytomas: associations with IL-6, cyclooxygenase-2, vascular endothelial growth factor, and microvessel morphometry. (19332096)
2009
14
Acromegaly and anaplastic astrocytoma: coincidence or pathophysiological relation? (18000757)
2008
15
Differential expression of 12 histone deacetylase (HDAC) genes in astrocytomas and normal brain tissue: class II and IV are hypoexpressed in glioblastomas. (18713462)
2008
16
Progression of astrocytomas and meningiomas: an evaluation in vitro. (17227292)
2007
17
Congenital diffuse anaplastic astrocytoma with ependymal and leptomeningeal spread: case report. (17443288)
2007
18
Progression-associated genes in astrocytoma identified by novel microarray gene expression data reanalysis. (17634619)
2007
19
Spinal cord astrocytoma presenting as "idiopathic" intracranial hypertension. (16298472)
2006
20
Immunohistochemical detection of epidermal growth factor receptor in human high-grade astrocytomas--a comparison between frozen- and paraffin sections. (15943037)
2005
21
Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas. (15523899)
2004
22
Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells. (15255942)
2004
23
Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. (15367334)
2004
24
Epigenetics in high-grade astrocytomas: opportunities for prevention and detection of brain tumors. (12724228)
2003
25
Deregulation of the TP53/p14ARF tumor suppressor pathway in low-grade diffuse astrocytomas and its influence on clinical course. (14581362)
2003
26
Muscarinic receptor-mediated activation of p70 S6 kinase 1 (S6K1) in 1321N1 astrocytoma cells: permissive role of phosphoinositide 3-kinase. (12747804)
2003
27
Stromelysin-1/matrix metalloproteinase-3 (MMP-3) expression accounts for invasive properties of human astrocytoma cell lines. (12866026)
2003
28
Relationship of PTEN, Mdm2 and p53 expression in astrocytoma]. (14575575)
2003
29
Desmoplastic infantile astrocytoma and ganglioglioma: a search for genomic characteristics. (12111357)
2002
30
Pilocytic astrocytomas do not show most of the genetic changes commonly seen in diffuse astrocytomas. (11119125)
2000
31
Expression and regulation of neuropilin-1 in human astrocytomas. (11058875)
2000
32
Spinal cord astrocytoma: response to PCV chemotherapy. (10668731)
2000
33
Expression of the Ets-1 transcription factor in human astrocytomas is associated with Fms-like tyrosine kinase-1 (Flt-1)/vascular endothelial growth factor receptor-1 synthesis and neoangiogenesis. (10554042)
1999
34
Astrocytoma cell interaction with elastin substrates: implications for astrocytoma invasive potential. (9890632)
1999
35
Glial fibrillary acidic protein and its fragments discriminate astrocytoma from oligodendroglioma. (10344289)
1999
36
Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma? (10630353)
1999
37
Astrocytomas and choroid plexus tumors in two families with identical p53 germline mutations. (9825943)
1998
38
A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade. (9739111)
1998
39
The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells. (9821106)
1998
40
Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis. (9568761)
1998
41
Keratin expression in astrocytomas: an immunofluorescent and biochemical reassessment. (9293896)
1997
42
Hypothalamic pilocytic astrocytoma presenting with intratumoral and subarachnoid hemorrhage. (9414929)
1997
43
Immunohistochemical characterization of subependymal giant cell astrocytomas. (8928613)
1996
44
Differential expression of two fibroblast growth factor-receptor genes is associated with malignant progression in human astrocytomas. (8290551)
1994
45
Simultaneous quantitation of cytokine mRNAs in interleukin-1 beta stimulated U373 human astrocytoma cells by a polymerisation chain reaction method involving co-amplification with an internal multi-specific control. (1296803)
1992
46
Epidermal growth factor and other mitogens induce binding of a protein complex to the c-fos serum response element in human astrocytoma and other cells. (1902475)
1991
47
Ras p21 expression in brain tumors: elevated expression in malignant astrocytomas and glioblastomas multiforme. (1667267)
1991
48
Intracranial metastasis of a spinal cord astrocytoma--case report. (1694278)
1990
49
Multiple primary intracranial tumors of different cell types: association of anaplastic astrocytoma and acoustic neurinoma--with review of the literature. (7179095)
1982
50
Gemistocytic astrocytoma: cytological observations on the rate of hydrolysis of some phosphoric acid esters. (13301910)
1955

Variations for Astrocytoma

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Expression for genes affiliated with Astrocytoma

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Astrocytoma

Search GEO for disease gene expression data for Astrocytoma.

Pathways for genes affiliated with Astrocytoma

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 13EMD Millipore, 31KEGG, 58SinoBiological, 39NCBI BioSystems Database, 61Thomson Reuters, 5Cell Signaling Technology, 55R&D Systems
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Pathways related to Astrocytoma according to GeneCards/GeneDecks:

(show all 42)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1LGALS3, S100B
210.1CDKN2A, TP53
39.9CDK4, TP53, MGMT
49.9CDK4, TP53, PTEN
5
Show member pathways
9.9CDK4, TP53, PTEN
6
Show member pathways
Prostate Cancer39
Integrated Cancer pathway39
Steroid Biosynthesis39
9.9CDK4, TP53, PTEN
79.9TP53, TP73, CDK4
8
Show member pathways
9.9TP53, CDKN2A, CDK4
99.9CDK4, CDKN2A, TP53
109.9CDK4, CDKN2A, TP53
11
Show member pathways
9.8TP53, TP73, CDKN2A
12
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.8TP53, TP73, CDKN2A
139.8GFAP, TNC, SYP, S100B
149.8CDK4, PCNA, TP53
15
Show member pathways
9.8CDK4, PCNA, TP53
169.8CDK4, PCNA, TP53
179.8TP53, PCNA, CDK4
18
Show member pathways
9.8GFAP, PTEN, S100B, EGFR
19
Show member pathways
9.8EGFR, TP53, PTEN, TNC
209.7PTEN, TP53, CDK4, EGFR
219.7EGFR, CDK4, TP53, PTEN
22
Show member pathways
Development EGFR signaling via PIP361
Development PDGF signaling via MAPK cascades61
Apoptosis and survival Anti apoptotic action of membrane bound ESR161
Signaling of Hepatocyte Growth Factor Receptor39
Development EGFR signaling via small GTPases61
Development Neurotrophin family signaling61
Apoptosis and survival NGF signaling pathway61
Apoptosis and survival Role of CDK5 in neuronal death and survival61
9.7PTEN, TP53, TP73, EGFR
23
Show member pathways
9.7EGFR, CDK4, CDKN2A, TP53
24
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.7CDKN2A, TP73, TP53, PTEN
25
Show member pathways
Toll-like receptor signaling pathway39
Regulation of toll-like receptor signaling pathway39
9.6PTEN, TP53, PCNA, CDK4
26
Show member pathways
Signal transduction PTEN pathway61
9.6PTEN, TP53, PCNA, EGFR
279.6PTEN, TP53, PCNA, CDKN2A
289.6TNC, PTEN, TP53, CDK4, EGFR
299.6CDK4, CDKN2A, PCNA, TP53
30
Show member pathways
9.6TP53, PCNA, CDKN2A, CDK4
31
Show member pathways
Cell cycle39
9.6TP53, PCNA, CDKN2A, CDK4
32
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.5IGFBP2, PTEN, TP53, PCNA
339.5GFAP, TP53, LGALS3, CDK4, EGFR
349.5EGFR, CDKN2A, TP53, PTEN, TNC
359.5PTEN, TP53, CDKN2A, CDK4, EGFR
36
Show member pathways
Signaling Pathways in Glioblastoma39
9.5PTEN, TP53, CDKN2A, CDK4, EGFR
37
Show member pathways
DNA damage response39
9.5PTEN, TP53, TP73, CDKN2A, CDK4
389.4PTEN, TP53, PCNA, CDK4, EGFR
399.4EGFR, PCNA, TP73, TP53, PTEN
409.3EGFR, CDK4, CDKN2A, TP53, PTEN, MGMT
41
Show member pathways
9.2GFAP, TNC, PTEN, TP53, CDKN2A, CDK4
42
Show member pathways
9.2MGMT, TP53, TP73, PCNA, CDKN2A, CDK4

Compounds for genes affiliated with Astrocytoma

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Sources:
46Novoseek, 12DrugBank, 52PharmGKB, 62Tocris Bioscience, 25HMDB, 30IUPHAR, 3BitterDB
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Compounds related to Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 160)
idCompoundScoreTop Affiliating Genes
1reticulin4610.0GFAP, S100B, PCNA, SYP
2bcnu4610.0EGFR, MGMT, CDKN2A, TP53, GFAP
3olomoucine46 1210.9CDK4, CDKN2A, PCNA, TP53
4dutp469.8PCNA, SYP, LGALS3, TP53, GFAP
5crcs469.8MGMT, TP53, CDKN2A, PTEN
6o6-methylguanine469.8CDKN2A, MGMT, PCNA, TP73, TP53
7silver469.7CDKN2A, PCNA, SYP, TNC, GFAP
8deoxyribonucleic acid469.7MGMT, IGFBP2, PTEN, PCNA, CDKN2A
9gemcitabine46 52 1211.6TP53, PCNA, EGFR, TP73, PTEN
10vincristine46 52 1211.6TP53, TP73, MGMT, CDKN2A, PTEN
11temozolomide46 1210.6NES, TP53, EGFR, CDKN2A, PCNA, MGMT
12thymidylate469.6CDK4, CDKN2A, TP53, MGMT, EGFR, PCNA
13agar469.6CDK4, EGFR, CDKN2A, LGALS3, PTEN, GFAP
14egcg469.6CDKN2A, EGFR, TP53, PCNA, CDK4, MGMT
15bromodeoxyuridine469.5GFAP, CDK4, S100B, PCNA, NES, IGFBP2
16camptothecin46 62 1211.5CDKN2A, PCNA, TP53, TP73, MGMT, CDK4
175-aza-2deoxycytidine469.5PTEN, CDKN2A, TP53, TP73, MGMT, PCNA
18etoposide46 52 62 1212.5TP53, SYP, PTEN, PCNA, S100B, LGALS3
19hematoxylin469.5CDKN2A, GFAP, PCNA, PTEN, S100B, LGALS3
20glycogen46 2510.4IGFBP2, GFAP, PTEN, LGALS3, SYP, CDK4
21doxorubicin46 52 1211.4EGFR, TP53, TP73, CDKN2A, CDK4, PTEN
22thymidine46 2510.3GFAP, IGFBP2, S100B, MGMT, PCNA, TP53
23butyrate469.3PCNA, GFAP, CDKN2A, TP53, LGALS3, CDK4
24leucine469.3CDK4, CDKN2A, IGFBP2, GFAP, PTEN, S100B
25formaldehyde46 2510.3MGMT, PCNA, SYP, S100B, TNC, GFAP
26ly294002469.3EGFR, CDK4, TP53, PTEN, IGFBP2, TNC
27genistein46 30 62 3 25 1214.3CDK4, CDKN2A, PCNA, SYP, PTEN, GFAP
28cycloheximide469.3IGFBP2, TNC, CDKN2A, PTEN, EGFR, GFAP
295fluorouracil469.2PTEN, EGFR, CDKN2A, MGMT, PCNA, TP73
30nitric oxide46 25 1211.2CDKN2A, LGALS3, MGMT, CDK4, SYP, NES
31paclitaxel46 52 1211.1PCNA, S100B, CDKN2A, MGMT, CDK4, GFAP
32mg 13246 6210.1PCNA, CDKN2A, EGFR, TP53, PTEN
33dexamethasone46 52 30 1212.0MGMT, TNC, GFAP, PCNA, S100B, CDKN2A
34glutamate469.0LGALS3, PCNA, IDH1, GFAP, TNC, NES
35testosterone46 62 25 1212.0EGFR, IGFBP2, PCNA, GFAP, SYP, S100B
36cysteine468.9GFAP, MGMT, PTEN, LGALS3, CDK4, CDKN2A
37h2o2468.9TNC, PTEN, TP53, LGALS3, SYP, CDKN2A
38oxygen46 259.8CDKN2A, CDK4, IGFBP2, GFAP, PTEN, NES
39lipid468.8TNC, PTEN, TP73, GFAP, IGFBP2, S100B
40arginine468.8TP73, GFAP, PTEN, PCNA, CDK4, CDKN2A
41oligonucleotide468.7MGMT, IGFBP2, PTEN, TP53, TNC, CDK4
42serine468.7S100B, CDKN2A, EGFR, SYP, TNC, IGFBP2
43cisplatin46 52 62 1211.7EGFR, CDK4, CDKN2A, PCNA, SYP, LGALS3
44tyrosine468.7IGFBP2, GFAP, EGFR, CDK4, S100B, SYP
45calcium46 52 25 1211.5IDH1, GFAP, IGFBP2, LGALS3, MGMT, TNC
46paraffin468.1CDK4, EGFR, CDKN2A, S100B, PCNA, MGMT
47progesterone46 30 62 25 1211.9IGFBP2, PTEN, TP53, TP73, NES, LGALS3
48vegf467.9EGFR, LGALS3, MGMT, IGFBP2, GFAP, TNC
49estrogen467.9IGFBP2, EGFR, CDK4, PCNA, S100B, CDKN2A
50retinoic acid46 258.5TNC, GFAP, IGFBP2, MGMT, PTEN, TP53

GO Terms for genes affiliated with Astrocytoma

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Sources:
17Gene Ontology
See all sources

Cellular components related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chromatinGO:0007859.9CDK4, TP73, TP53
2cytoplasmGO:0057377.7TRIM47, IDH1, GFAP, PTEN, TP53, NES
3nucleusGO:0056347.5LGALS3, TP73, TP53, PTEN, MGMT, PCNA

Biological processes related to Astrocytoma according to GeneCards/GeneDecks:

(show all 21)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of cell sizeGO:04579310.3CDK4, TP73
2long-term synaptic potentiationGO:06029110.3S100B, PTEN, GFAP
3regulation of neuronal synaptic plasticityGO:04816810.3S100B, SYP
4mitotic G1 DNA damage checkpointGO:03157110.3TP73, TP53
5replicative senescenceGO:09039910.3CDKN2A, TP53
6learning or memoryGO:00761110.3EGFR, S100B, PTEN
7response to ethanolGO:04547110.3PTEN, TNC, MGMT
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.2TP73, TP53
9digestive tract morphogenesisGO:04854610.2EGFR, TP73
10positive regulation of oligodendrocyte differentiationGO:04871410.1TP73, OLIG2
11central nervous system developmentGO:00741710.1S100B, NES, TP53, PTEN
12positive regulation of cell cycle arrestGO:07115810.1CDKN2A, TP53
13response to X-rayGO:01016510.0TP53, TP73
14mismatch repairGO:0062989.9PCNA, TP73
15cell cycle arrestGO:0070509.9TP53, TP73, CDKN2A
16response to drugGO:0424939.9MGMT, IGFBP2, PTEN, CDK4
17positive regulation of cell proliferationGO:0082849.9TNC, PTEN, S100B, CDK4, EGFR
18positive regulation of apoptotic processGO:0430659.9PTEN, TP53, TP73, S100B, CDK4
19phosphatidylinositol-mediated signalingGO:0480159.9EGFR, PCNA, PTEN
20cell proliferationGO:0082839.8PTEN, TP53, PCNA, S100B, EGFR
21G1/S transition of mitotic cell cycleGO:0000829.4CDK4, CDKN2A, PCNA

Molecular functions related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1MDM2/MDM4 family protein bindingGO:09737110.1CDKN2A, TP53
2p53 bindingGO:0020399.5CDKN2A, TP73, TP53
3protein kinase bindingGO:0199019.4PTEN, TP53, TP73, CDKN2A, EGFR
4identical protein bindingGO:0428029.2EGFR, S100B, PCNA, SYP, TP73, TP53

Products for genes affiliated with Astrocytoma

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Sources for Astrocytoma

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet