MCID: AST007
MIFTS: 72

Astrocytoma malady

Neuronal diseases, Cancer diseases categories

Summaries for Astrocytoma

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8Disease Ontology, 63Wikipedia, 32MalaCards
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Disease Ontology:8 A malignant glioma that is has material basis in astocyte cells, a type of glial cell, located in the cerebrum.

MalaCards: Astrocytoma, also known as cerebral astrocytoma, is related to subependymal giant cell astrocytoma and tuberous sclerosis. An important gene associated with Astrocytoma is KIAA1549 (KIAA1549), and among its related pathways are Rho Family GTPases and PI3K-Akt signaling pathway. The drugs cisplatin and temozolomide and the compounds vegf and retinoic acid have been mentioned in the context of this disorder. Affiliated tissues include the cerebrum, brain and spinal cord, and related mouse phenotypes are cellular and mortality/aging.

Wikipedia:63 Astrocytomas are a type of cancer of the brain. They originate in a particular kind of glial cells,... more...

Aliases & Classifications for Astrocytoma

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8Disease Ontology, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Cancer diseases
Anatomical: Neuronal diseases


Aliases & Descriptions:

astrocytoma 8 44 60
cerebral astrocytoma 8 60
astrocytoma, no icd-o subtype 8
astrocytoma of cerebrum 8
astrocytoma of brain 8
astrocytic tumor 8
astroglioma 8


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Disease Ontology8 DOID:3069
MeSH34 D001254

Related Diseases for Astrocytoma

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Astrocytoma family:

Juvenile Astrocytoma

Diseases related to Astrocytoma via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 325)
idRelated DiseaseScoreTop Affiliating Genes
1subependymal giant cell astrocytoma31.2TSC1, SYP, S100B
2tuberous sclerosis31.1TSC1, PTEN, GFAP, SYP, NES, S100B
3juvenile pilocytic astrocytoma30.9TNC
4glioblastoma multiforme30.9TP53, TSC1, PTEN, GFAP, CDK4, IGFBP2
5oligodendroglioma30.8TP73, PTEN, GFAP, OLIG2, EGFR, MGMT
6gemistocytic astrocytoma30.7PTEN, GFAP, S100B
7medulloblastoma30.7TP53, TP73, GFAP, CDK4, SYP, NES
8meningioma30.6TP73, TSC1, PTEN, GFAP, PCNA, SYP
9pilocytic astrocytoma30.6TP73, TSC1, LGALS3, PTEN, GFAP, OLIG2
10neuroblastoma30.5TP53, SYP
11anaplastic astrocytoma30.5TP53, TP73, LGALS3, PTEN, GFAP, OLIG2
12malignant glioma30.4TP53, PTEN, GFAP, KIAA1549, OLIG2, PCNA
13ganglioglioma30.2TSC1, GFAP, SYP, S100B
14retinoblastoma30.2TP53, TP73, GFAP, PCNA, CDK4, IGFBP2
15leukemia30.2TP53, TP73, OLIG2, CDK4, IGFBP2, NES
16adenoma30.1TP53, TP73, TSC1, LGALS3, PCNA, CDK4
17dysembryoplastic neuroepithelial tumor30.1KIAA1549, OLIG2, SYP
18hydrocephalus30.1TSC1, NES
19acute leukemia30.1IGFBP2
20adenocarcinoma30.0TP53, TP73, TSC1, LGALS3, PTEN, PCNA
21gliosarcoma30.0PTEN, GFAP, CDK4
22meningitis30.0IGFBP2
23angiomyolipoma30.0TSC1
24brain cancer30.0EGFR, MGMT
25melanoma29.9TP53, TP73, LGALS3, PTEN, PCNA, CDK4
26pituitary adenoma29.9TP73, LGALS3, PCNA, CDK4, SYP, NES
27colon cancer29.9TP53, TP73, LGALS3, CDK4, IGFBP2, EGFR
28lung small cell carcinoma29.9TP53, IGFBP2, SYP, EGFR, MGMT
29hemangioblastoma29.9GFAP, SYP, NES, S100B
30giant cell glioblastoma29.9PTEN, GFAP, EGFR
31central neurocytoma29.9GFAP, OLIG2, SYP
32oligoastrocytoma29.9GFAP, MGMT
33gangliocytoma29.9PTEN, SYP
34breast cancer29.7TP53, TP73, TSC1, LGALS3, PTEN, PCNA
35prostate cancer29.7TP53, TP73, LGALS3, PTEN, PCNA, CDK4
36colorectal cancer29.7TP53, TP73, LGALS3, PTEN, PCNA, IGFBP2
37neurofibroma29.6TP73, SYP, TNC, S100B
38pleomorphic adenoma29.6GFAP, PCNA, TNC, S100B
39papilloma29.6TP53, TP73, PCNA
40osteosarcoma29.6TP53, TP73, CDK4
41chordoma29.6LGALS3, GFAP, S100B
42multiple sclerosis29.6GFAP, OLIG2, IGFBP2, TNC
43xeroderma pigmentosum29.6TP53, PCNA, MGMT
44alzheimer's disease29.6TSC1, GFAP, SYP, S100B
45lung adenocarcinoma29.6TP53, TP73, EGFR, MGMT
46gliomatosis cerebri29.6PTEN, GFAP
47fibrosarcoma29.6NES, TNC
48myeloid leukemia29.6TP73, CDK4
49neurilemmoma29.6GFAP, NES, S100B
50pineoblastoma29.6GFAP, SYP

Graphical network of the top 20 diseases related to Astrocytoma:



Diseases related to astrocytoma

Clinical Features for Astrocytoma

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Drugs & Therapeutics for Astrocytoma

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

Search CenterWatch for Astrocytoma

Drug clinical trials:

Search ClinicalTrials for Astrocytoma

Search NIH Clinical Center for Astrocytoma

Search CenterWatch for Astrocytoma

Inferred drug relations via UMLS60/NDF-RT40:

Genetic Tests for Astrocytoma

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Anatomical Context for Astrocytoma

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Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Astrocytoma:

32
Brain, Spinal cord, Endothelial, Cerebellum, Pituitary, Pineal, Cortex, Temporal lobe, Thyroid, Breast, Testes, Colon, Ovary, Monocytes, Retina, Hypothalamus, T cells, Testis, Bone, Lung, Eye, Tongue, Myeloid, Prefrontal cortex, Skin, Liver, Prostate, Bone marrow, B cells, Medulla oblongata

FMA organs/tissues related to Astrocytoma:

14
The cerebrum

Animal Models for Astrocytoma or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Astrocytoma:

36 (show all 23)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538412.7EGFR, NES, NRN1, CDK4, PCNA, OLIG2
2MP:001076812.7PCNA, CDK4, NES, EGFR, MGMT, OLIG2
3MP:000538612.6S100B, TNC, NES, NRN1, CDK4, OLIG2
4MP:000537812.5CDK4, NRN1, NES, EGFR, PCNA, OLIG2
5MP:000538712.4IDH1, EGFR, IGFBP2, CDK4, PCNA, GFAP
6MP:000363112.3TP73, TNC, SYP, NRN1, CDK4, OLIG2
7MP:000538512.2EGFR, IGFBP2, CDK4, GFAP, PTEN, LGALS3
8MP:000539712.1IDH1, EGFR, IGFBP2, CDK4, PCNA, PTEN
9MP:000287312.0S100B, TNC, EGFR, SYP, IGFBP2, GFAP
10MP:000200611.9MGMT, EGFR, CDK4, OLIG2, PTEN, TSC1
11MP:000301211.8MGMT, EGFR, SYP, NRN1, PCNA, OLIG2
12MP:000538811.8EGFR, OLIG2, PTEN, LGALS3, TSC1, TP73
13MP:000538111.8EGFR, CDK4, GFAP, PTEN, LGALS3, TP73
14MP:000537611.7IDH1, TNC, MGMT, CDK4, GFAP, TSC1
15MP:000538911.6EGFR, PCNA, PTEN, TSC1, TP73, TP53
16MP:000537911.4MGMT, CDK4, TP73, TP53
17MP:000536911.4CDK4, OLIG2, GFAP, TSC1, TP53
18MP:000536711.2EGFR, LGALS3, TSC1
19MP:001077111.2S100B, CDK4, PTEN, TSC1, TP53
20MP:000537011.1EGFR, IGFBP2, CDK4, PTEN, TSC1, TP53
21MP:000539011.0TSC1, LGALS3, OLIG2
22MP:000539110.9GFAP, EGFR
23MP:000538010.8TSC1, NES

Publications for Astrocytoma

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50PubMed
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Articles related to Astrocytoma:

(show top 50)    (show all 1876)
idTitleAuthorsYear
1
Resection of subependymal giant cell astrocytoma guided by intraoperative magnetic resonance imaging and neuronavigation. (23397586)
2013
2
Insulin-like growth factor 2 mRNA binding protein 3 expression is an independent prognostic factor in pediatric pilocytic and pilomyxoid astrocytoma. (23584203)
2013
3
Paradoxical role of 3-methyladenine in pyocyanin-induced toxicity in 1321N1 astrocytoma and SH-SY5Y neuroblastoma cells. (23525265)
2013
4
Neurosurgical treatment of low-grade cerebellar astrocytoma in children and adolescents: a single consecutive institutional series of 100 patients. (23240848)
2013
5
Brevican, neurocan, tenascin-C and versican are mainly responsible for the invasiveness of low-grade astrocytoma. (21997179)
2012
6
Should we reoperate for recurrent high-grade astrocytoma? (21590314)
2011
7
Spinal pilocytic astrocytoma: MR imaging findings at first presentation and following surgery. (20478675)
2011
8
Influence of caloric restriction on constitutive expression of NF-I_B in an experimental mouse astrocytoma. (21479220)
2011
9
Pilocytic astrocytoma with neoplastic gemistocytes undergoing spontaneous transformation to glioblastoma multiforme without prior radiotherapy. (21349721)
2011
10
Management of intramedullary cystic pilocytic astrocytoma with rhenium-186 intracavitary irradiation: case report. (20404673)
2010
11
Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6). (20018235)
2010
12
Bulky subependymal giant cell astrocytoma with profuse blood supply without tuberous sclerosis. (20956931)
2010
13
Loss of inhibitor of growth (ING-4) is implicated in the pathogenesis and progression of human astrocytomas. (19775294)
2010
14
Proapoptotic ginsenosides compound K and Rh enhance Fas-induced cell death of human astrocytoma cells through distinct apoptotic signaling pathways. (19688070)
2009
15
Giant Cell Astrocytoma of the Retina in a 1-Month-Old Infant. (19873950)
2009
16
Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor. (18412947)
2008
17
The doppel (Dpl) protein influences in vitro migration capability in astrocytoma-derived cells. (18936526)
2008
18
Three-hit hypothesis in astrocytoma: tracing the polymorphism D1853N in ATM gene through a pedigree of the proband affected with primary brain tumor. (18465141)
2008
19
A nitric oxide/Ca(2+)/calmodulin/ERK1/2 mitogen-activated protein kinase pathway is involved in the mitogenic effect of IL-1beta in human astrocytoma cells. (18297103)
2008
20
Detection of a hypersialylated beta1 integrin endogenously expressed in the human astrocytoma cell line A172. (18425328)
2008
21
Role of myosin II activity and the regulation of myosin light chain phosphorylation in astrocytomas. (17896341)
2008
22
Retinoic acid-inducible gene-I mediates RANTES/CCL5 expression in U373MG human astrocytoma cells stimulated with double-stranded RNA. (17395328)
2007
23
Comparative non-cholinergic neurotoxic effects of paraoxon and diisopropyl fluorophosphate (DFP) on human neuroblastoma and astrocytoma cell lines. (17223147)
2007
24
Immunohistochemical expression of peripheral benzodiazepine receptors in human astrocytomas and its correlation with grade of malignancy, proliferation, apoptosis and survival. (16868661)
2007
25
Pilomyxoid astrocytoma: neuroimaging with clinicopathologic correlates in 4 cases followed over time. (17609624)
2007
26
Survivin subcellular localization in high-grade astrocytomas: simultaneous expression in both nucleus and cytoplasm is negative prognostic marker. (17151933)
2007
27
Prognostic significance of loss of O6-methylguanine-DNA methyltransferase expression in supratentorial diffuse low-grade astrocytoma. (17825378)
2007
28
Ghrelin and the growth hormone secretagogue receptor constitute a novel autocrine pathway in astrocytoma motility. (16527811)
2006
29
Immunohistochemical detection of epidermal growth factor receptor in human high-grade astrocytomas--a comparison between frozen- and paraffin sections. (15943037)
2005
30
Possible association of p53 codon 72 polymorphism with susceptibility to adult and pediatric high-grade astrocytomas. (15950766)
2005
31
Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. (16357147)
2005
32
A phase I trial of surgery, Gliadel wafer implantation, and immediate postoperative carboplatin in combination with radiation therapy for primary anaplastic astrocytoma or glioblastoma multiforme. (15937647)
2005
33
Identification of astrocytoma associated genes including cell surface markers. (15265232)
2004
34
The clinical significance of cathepsin S expression in human astrocytomas. (12819022)
2003
35
Mitosin and DNA topoisomerase IIalpha: two novel proliferation markers in the prognostication of diffuse astrocytoma patient survival. (11556747)
2001
36
Differential effects of oncostatin M and leukaemia inhibitory factor expression in astrocytoma cells. (11284716)
2001
37
Loss of neurofibromin is associated with activation of RAS/MAPK and PI3-K/AKT signaling in a neurofibromatosis 1 astrocytoma. (11005256)
2000
38
Overexpression of cyclin A and cyclin B1 proteins in astrocytomas. (10656729)
2000
39
Procarbazine, lomustine, and vincristine (PCV) chemotherapy for anaplastic astrocytoma: A retrospective review of radiation therapy oncology group protocols comparing survival with carmustine or PCV adjuvant chemotherapy. (10550132)
1999
40
Subependymal giant cell astrocytoma associated with tuberous sclerosis exhibiting rapid regrowth after 17 years: a case report]. (10396738)
1999
41
Image interpretation session: 1998. Tuberous sclerosis with multiple bilateral renal cysts and a subependymal giant cell astrocytoma. (10722364)
1999
42
Pilocytic astrocytoma of the posterior fossa: a follow-up study in 15 patients. (10389282)
1999
43
A new factor derived from 1321N1 human astrocytoma cells causes differentiation of PC-12 cells mediated through mitogen-activated protein kinase cascade. (9739111)
1998
44
The importance of cell density in the interpretation of growth factor effects on collagenase IV activity release and extracellular matrix production from C6 astrocytoma cells. (9821106)
1998
45
Subependymal giant-cell astrocytoma associated with tuberous sclerosis: case report. (9795959)
1998
46
Induction of RANTES expression by astrocytes and astrocytoma cell lines. (8982121)
1996
47
Degradation of collagen type IV by C6 astrocytoma cells. (8523079)
1995
48
Substance P enhances forskolin-stimulated cyclic AMP production in human UC11MG astrocytoma cells. (7513037)
1994
49
Regulation of the release of interleukin-6 from human astrocytoma cells. (7519668)
1994
50
An anaplastic astrocytoma (glioblastoma) in the cerebellum of a dog. (1858256)
1991

Genetic Variations for Astrocytoma

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Expression for genes affiliated with Astrocytoma

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Astrocytoma

Search GEO for disease gene expression data for Astrocytoma.

Pathways for genes affiliated with Astrocytoma

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Sources:
51QIAGEN, 29KEGG, 37NCBI BioSystems Database, 52R&D Systems, 12EMD Millipore, 4Cell Signaling Technology, 53Reactome
See all sources

Pathways related to Astrocytoma according to GeneCards/GeneDecks:

(show all 26)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.6TNC, EGFR, CDK4, GFAP, PTEN, TSC1
211.4TNC, EGFR, CDK4, PTEN, TSC1, TP53
311.4TP53, TSC1, PTEN, CDK4, EGFR, MGMT
411.3TP53, LGALS3, GFAP, CDK4, EGFR
511.3EGFR, CDK4, PTEN, TSC1, TP53
611.3EGFR, CDK4, PTEN, TSC1, TP53
711.3EGFR, CDK4, PCNA, PTEN, TP53
811.3EGFR, PCNA, PTEN, TP73, TP53
9
Hide members
11.3IGFBP2, PCNA, PTEN, TSC1, TP53
1011.1GFAP, SYP, TNC, S100B
11
Hide members
11.1S100B, EGFR, GFAP, PTEN
1211.1TP53, PTEN, EGFR, TNC
13
Hide members
11.1TP53, TP73, PTEN, CDK4
14
Hide members
11.1EGFR, PTEN, TP73, TP53
15
Hide members
11.1CDK4, PTEN, TSC1, TP53
16
Hide members
11.1CDK4, PCNA, PTEN, TP53
17
Hide members
11.1EGFR, PCNA, PTEN, TP53
18
Hide members
11.1MGMT, CDK4, PCNA, TP73
1911.0TP53, PTEN, CDK4
2011.0TP53, CDK4, MGMT
21
Hide members
11.0EGFR, CDK4, TP53
2211.0TP53, PCNA, CDK4
2311.0TP53, PCNA, CDK4
2410.8LGALS3, S100B
25
Hide members
10.8TP73, TP53
26
Hide members
10.8TP53, TSC1

Compounds for genes affiliated with Astrocytoma

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Sources:
44Novoseek, 24HMDB, 59Tocris Bioscience, 28IUPHAR, 11DrugBank, 49PharmGKB, 2BitterDB
See all sources

Compounds related to Astrocytoma according to GeneCards/GeneDecks:

(show top 50)    (show all 118)
idCompoundScoreTop Affiliating Genes
1vegf4413.3TNC, MGMT, EGFR, NES, SYP, IGFBP2
2retinoic acid44 2414.3OLIG2, GFAP, PTEN, LGALS3, TP73, TP53
3progesterone44 59 28 11 2417.2TNC, S100B, MGMT, EGFR, NES, SYP
4paraffin4413.1S100B, TP53, TP73, TSC1, LGALS3, TNC
5tyrosine4412.8PTEN, LGALS3, TP73, CDK4, IGFBP2, GFAP
6cisplatin44 49 59 1115.5EGFR, TP73, SYP, GFAP, LGALS3, PTEN
7oligonucleotide4412.3TP73, TNC, TP53, LGALS3, PTEN, CDK4
8arginine4412.3TP53, TP73, LGALS3, PTEN, GFAP, PCNA
9cysteine4412.3S100B, TNC, LGALS3, MGMT, SYP, CDK4
10lipid4412.2GFAP, TP73, LGALS3, IGFBP2, SYP, NES
11formaldehyde44 2413.2IGFBP2, PCNA, SYP, MGMT, TNC, LGALS3
12glycogen44 2413.2CDK4, SYP, S100B, IGFBP2, LGALS3, TSC1
13testosterone44 59 11 2415.1PTEN, EGFR, SYP, IGFBP2, CDK4, PCNA
145fluorouracil4412.0CDK4, TP73, MGMT, PTEN, PCNA, EGFR
15genistein44 28 59 2 11 2417.0PCNA, CDK4, MGMT, PTEN, GFAP, EGFR
16thymidine44 2412.9GFAP, PCNA, CDK4, IGFBP2, TP53, S100B
17hematoxylin4411.9S100B, PCNA, SYP, LGALS3, PTEN, GFAP
18paclitaxel44 49 1113.9PTEN, TP53, CDK4, GFAP, EGFR, S100B
19bromodeoxyuridine4411.8PCNA, GFAP, CDK4, IGFBP2, NES, S100B
20temozolomide44 1112.7NES, EGFR, MGMT, TP53, PCNA
21dutp4411.7TP53, SYP, PCNA, GFAP, LGALS3
22doxorubicin44 49 1113.7TP53, MGMT, CDK4, PTEN, TP73, EGFR
23gemcitabine44 49 1113.6TP73, TP53, PTEN, EGFR, PCNA
24dexamethasone44 49 28 1114.6S100B, MGMT, CDK4, PCNA, GFAP
25thymidylate4411.6PCNA, TP53, MGMT, CDK4, EGFR
26camptothecin44 59 1113.6TP53, CDK4, MGMT, PCNA, TP73
27phosphatidylinositol4411.6TSC1, IGFBP2, TNC, LGALS3, PTEN, EGFR
28proline4411.6TP73, TP53, MGMT, S100B, LGALS3, CDK4
29glutamine4411.5S100B, PCNA, SYP, GFAP, LGALS3, IDH1
30reticulin4411.5S100B, SYP, PCNA, GFAP
315-aza-2deoxycytidine4411.5PTEN, PCNA, TP73, TP53, MGMT
32serine4411.5TSC1, GFAP, SYP, S100B
33bcnu4411.5TP53, GFAP, EGFR, MGMT
34o6-methylguanine4411.5TP73, TP53, MGMT, PCNA
35glucose4411.5MGMT, IGFBP2, PTEN, GFAP, TSC1
36acth4411.4SYP, LGALS3, IGFBP2, GFAP, S100B
37ly2940024411.4CDK4, EGFR, TNC, IGFBP2
38deoxyribonucleic acid4411.4PCNA, IGFBP2, MGMT, PTEN
39estradiol44 11 2413.3PTEN, SYP, GFAP, CDK4
40eosin4411.3S100B, PCNA, GFAP
41agar4411.3EGFR, LGALS3, CDK4, GFAP, PTEN
42s 1004411.3S100B, SYP, GFAP
43streptozotocin4411.2NES, GFAP, SYP
44etoposide44 49 59 1114.2S100B, LGALS3
45carboplatin44 49 1113.2TP53, CDK4, EGFR, MGMT
46gaba4411.2TNC, S100B, NES, SYP, GFAP
47glutamate4411.1GFAP, IDH1
48estrogen4411.1GFAP
49cycloheximide4411.0IGFBP2
50silver4410.8GFAP, PCNA, SYP, TNC

GO Terms for genes affiliated with Astrocytoma

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Sources:
16Gene Ontology
See all sources

Cellular components related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:00573712.1TP53, IDH1, S100B, EGFR, NES, TRIM47
2chromatinGO:00078511.0TP53, TP73, CDK4

Biological processes related to Astrocytoma according to GeneCards/GeneDecks:

(show all 10)
idNameGO IDScoreTop Affiliating Genes
1cell proliferationGO:00828311.4S100B, EGFR, PCNA, PTEN, TP53
2positive regulation of cell proliferationGO:00828411.4S100B, TNC, EGFR, CDK4, PTEN
3central nervous system developmentGO:00741711.3TP53, PTEN, NES, S100B
4long-term synaptic potentiationGO:06029111.2PTEN, GFAP, S100B
5positive regulation of cell sizeGO:04579310.9TP73, CDK4
6negative regulation of cell sizeGO:04579210.9TSC1, PTEN
7positive regulation of apoptotic processGO:04306510.8TP53, TP73, CDK4, S100B
8positive regulation of oligodendrocyte differentiationGO:04871410.8OLIG2, TP73
9DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.8TP53, TP73
10mitotic G1 DNA damage checkpointGO:03157110.7TP73, TP53

Molecular functions related to Astrocytoma according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1identical protein bindingGO:04280211.4TP53, TP73, PCNA, SYP, EGFR, S100B

Products for genes affiliated with Astrocytoma

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Astrocytoma

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet