Atherosclerosis malady

MedlinePlus: Atherosclerosis is a disease in which plaque builds up inside your arteries. plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. over time, plaque hardens and narrows your arteries. that limits the flow of oxygen-rich blood to your body and can lead to serious problems, including coronary artery disease. these arteries supply blood to your heart. when they are blocked, you can suffer angina or a heart attack. carotid artery disease. these arteries supply blood to your brain. when they are blocked you can suffer a stroke. peripheral arterial disease. these arteries are in your arms, legs and pelvis. when they are blocked, you can suffer from numbness, pain and sometimes infections. atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. many people don't know they have the disease until they have a medical emergency. a physical examination, imaging and other diagnostic tests can tell if you have it. treatments include medicines, and medical procedures or surgery. lifestyle changes can also help. these include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. nih: national heart, lung, and blood institute²³

MalaCards: Atherosclerosis is related to cholesterol and prostatitis. An important gene associated with Atherosclerosis is ALOX5 (arachidonate 5-lipoxygenase), and among its related pathways are MAPK Family Pathway and MIF Regulation of Innate Immune Cells. The compounds phosphotyrosine and atp have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, whole blood and brain, and related mouse phenotypes are mortality/aging and skeleton.

Wikipedia: Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a condition in which an...⁴⁴ more...

Aliases & Descriptions:

atherosclerosis 6 17 8 33 32 23 43

Diseases related to atherosclerosis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 899)

id	Related Disease	Score	Top Affiliating Genes
1	cholesterol	108.7	ZNF202, PIK3C2A, PIK3CG, LRP1, LRP5, LRP6
2	prostatitis	103.9	ZNF673, PIK3C2A, PIK3CG, LRP1, LRP5, KL
3	pancreatitis	98.7	PIK3C2A, PIK3CG, PI3, LRP1, LRP5, LRP8
4	neuronitis	97.8	PIK3C2A, PIK3CG, LRP1, LRP6, LRP8, KLF10
5	obesity	96.5	PIK3C2A, PIK3CG, LRP1, LRP5, COG2, REN
6	hypertension	96.5	PIK3C2A, PIK3CG, LRP1, LRP5, LRP6, LRP8
7	diabetes mellitus	94.8	ZNF673, PIK3C2A, PIK3CG, PI3, LRP5, LRP6
8	cerebritis	91.1	PIK3C2A, PIK3CG, LRP1, LRP6, LRP8, COG2
9	alzheimer's disease	88.5	PIK3CG, WDFY4, LRP1, LRP6, LRP8, COG2
10	coronary heart disease	88.1	ZNF202, PIK3C2A, LRP1, LRP5, COG2, RETN
11	fibrosis	85.9	PIK3CG, PI3, LRP1, KL, NCF1, REG1A
12	insulin resistance	83.8	PIK3CG, LRP1, COG2, REN, RETN, CNR1
13	hypoxia	81.4	PIK3C2A, PIK3CG, LRP1, LRP5, KLF2, REN
14	carcinoma	79.1	ZNF673, ZNF202, PIK3C2A, PIK3CG, PI3, LRP1
15	ischemia	79.1	PIK3C2A, PIK3CG, COG2, KLF4, REN, RETN
16	nephropathy	77.4	LRP1, COG2, PDCD1, REG1A, REN, RETN
17	retinitis	75.3	PIK3C2A, PIK3CG, LRP1, LRP5, SGCB, CNR1
18	lupus erythematosus	73.6	PIK3C2A, PIK3CG, WDFY4, LRRC18, COG2, PDCD1
19	pneumonia	71.3	PIK3C2A, PI3, COG2, KL, VTN, SFTPB
20	colon cancer	70.3	PIK3CG, LRP6, KLF4, REG1A, RETN, CNR1
21	peritonitis	69.5	PIK3C2A, LRP1, COG2, REG1A, REN, VWF
22	gonococcal synovitis	67.9	PIK3CG, PI3, LRP1, KLF4, PDCD1, REG1A
23	multiple sclerosis	67.7	LRP1, PDCD1, CNR1, CNR2, VWF, VTN
24	thrombosis	67.5	PIK3C2A, PIK3CG, LRP1, COG2, REN, RETN
25	hypercholesterolemia	67.1	PIK3C2A, LRP1, COG2, RETN, VWF, PCSK9
26	tuberculosis	63.9	PIK3CG, NCEH1, NCF1, PDCD1, GCK, GCH1
27	essential hypertension	63.6	COG2, REN, RETN, KISS1, VWF, GCK
28	hyperlipidemia	63.3	PIK3C2A, PIK3CG, LRP1, COG2, RETN, SGCB
29	leukemia	63.3	ZNF673, PIK3C2A, PIK3CG, LRP1, LRP5, LRP6
30	psoriasis	61.7	PI3, LRP1, RETN, CNR1, VTN, PCNA
31	homocysteine	61.4	PIK3C2A, COG2, NCF1, REN, RETN, VWF
32	coronary artery anomaly	60.7	PIK3C2A, LRP1, COG2, RETN, VWF, VTN
33	aortic aneurysm	60.6	PIK3C2A, LRP5, REN, RETN, VWF, SELE
34	vascular disease	60.2	LRP1, KLF2, RETN, SGCB, VWF, VTN
35	hyperglycemia	58.9	PIK3C2A, PIK3CG, COG2, RETN, CNR1, VWF
36	dementia	57.7	PIK3C2A, PIK3CG, LRP1, LRP8, VWF, PCSK9
37	type 2 diabetes mellitus	57.1	COG2, RETN, CNR1, VWF, GCKR, GCK
38	blindness	57.1	PIK3C2A, PIK3CG, LRP5, COG2, REN, CNR1
39	gingivitis	56.7	PIK3CG, CNR1, CNR2, PCNA, SELE, SELL
40	adenocarcinoma	55.5	PIK3C2A, PIK3CG, LRP1, KLF10, KLF4, REG1A
41	diabetic retinopathy	54.2	PIK3CG, CNR1, VWF, VTN, RBP4, SELE
42	hepatocellular carcinoma	53.3	PIK3CG, KL, PDCD1, REG1A, CNR1, CNR2
43	endometriosis	52.7	VTN, PCNA, PCSK5, SERPINC1, SERPINE1, BSG
44	thyroiditis	52.3	PIK3C2A, PIK3CG, LRP1, COG2, KLF10, KLF4
45	vasculitis	51.6	LRP1, PDCD1, REN, VWF, SELE, SELL
46	cerebral infarction	50.8	COG2, NCF1, VWF, RBP4, SELP, SERPINC1
47	melanoma	50.4	PIK3C2A, PIK3CG, PI3, LRP1, KL, NCEH1
48	hypertriglyceridemia	49.6	LRP1, COG2, GCKR, RBP4, SELE, SELP
49	proteinuria	49.5	PIK3C2A, COG2, REN, VWF, VTN, RBP4
50	influenza	49.4	PIK3C2A, PIK3CG, VTN, PCSK5, SELL, SERPINE1

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to atherosclerosis:

²²

id	Organ / Tissue -> Anatomical Compartment -> Cell	Relevance
1	Endothelium -> Arteries -> Arterial endothelial cells	Affected by disease
2	Heart -> Endocardium -> Vascular Smooth Muscle Cells	Affected by disease

MGI Mouse Phenotypes related to atherosclerosis:

²⁵ (show all 29)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	mortality/aging	MP:0010768	INF	PIK3C2A, LRP1, LRP5, LRP6, LRP8, KL
2	skeleton phenotype	MP:0005390	INF	PIK3CG, LRP1, LRP6, KLF10, KLF2, CNR1
3	limbs/digits/tail phenotype	MP:0005371	INF	LRP5, LRP6, KL, KLF10, PCSK5, SEPP1
4	cardiovascular system phenotype	MP:0005385	46.7	PIK3CG, LRP1, LRP5, KL, KLF2, NCEH1
5	muscle phenotype	MP:0005369	30.2	PIK3CG, LRP1, KL, KLF2, PDCD1, REN
6	nervous system phenotype	MP:0003631	27.5	LRP1, LRP5, LRP6, LRP8, KL, PDCD1
7	normal phenotype	MP:0002873	24.9	LRP1, LRP5, LRP6, LRP8, KLF2, KLF4
8	digestive/alimentary phenotype	MP:0005381	24.5	LRP6, KL, KLF4, KISS1, KISS1R, VWF
9	liver/biliary system phenotype	MP:0005370	23.9	LRP5, LRP6, KLF2, RETN, PCSK9, GCK
10	vision/eye phenotype	MP:0005391	23.7	LRP5, LRP6, PDCD1, RBP4, SELE, SELP
11	tumorigenesis	MP:0002006	23.5	KLF10, KLF4, SELL, SERPINE1, MYD88, RAG2
12	adipose tissue phenotype	MP:0005375	23.4	PIK3C2A, LRP1, LRP6, KL, RETN, CNR1
13	renal/urinary system phenotype	MP:0005367	21.9	LRP6, KL, PDCD1, REN, KISS1, KISS1R
14	respiratory system phenotype	MP:0005388	18.7	LRP6, KL, KLF2, PCSK5, SELL, SELP
15	no phenotypic analysis	MP:0003012	17.2	LRP6, CNR1, PCNA, PCSK5, VEGFA, VCAM1
16	embryogenesis phenotype	MP:0005380	15.2	LRP5, LRP6, KLF2, GCLC, SERPINC1, MYOCD
17	other phenotype	MP:0005395	14.9	KL, CNR1, CLU, SCNN1G, LEPR, LDLR
18	pigmentation phenotype	MP:0001186	12.5	LRP5, SERPINC1, VLDLR, LMNA, MYO7A, PAX6
19	cellular phenotype	MP:0005384	INF	PIK3CG, LRP5, LRP6, LRP8, KL, KLF10
20	behavior/neurological phenotype	MP:0005386	INF	LRP1, LRP5, LRP6, LRP8, KL, KLF4
21	craniofacial phenotype	MP:0005382	INF	LRP5, LRP6, KLF2, KLF4, PCSK5, BMP4
22	integument phenotype	MP:0010771	INF	PIK3CG, LRP6, KL, KLF10, KLF4, CNR1
23	reproductive system phenotype	MP:0005389	INF	LRP6, LRP8, KLF4, REG1A, REN, KISS1
24	endocrine/exocrine gland phenotype	MP:0005379	INF	LRP5, KL, KLF4, REG1A, KISS1, KISS1R
25	homeostasis/metabolism phenotype	MP:0005376	INF	PIK3C2A, PIK3CG, LRP1, LRP5, LRP6, KL
26	immune system phenotype	MP:0005387	INF	LRP1, LRP5, KL, KLF2, NCEH1, REN
27	hearing/vestibular/ear phenotype	MP:0005377	INF	LRP6, VDR, LMNA, MYD88, MYO7A, BMP2
28	hematopoietic system phenotype	MP:0005397	INF	KLF2, PDCD1, KISS1R, VSIG4, PCNA, SERPIND1
29	growth/size phenotype	MP:0005378	INF	PIK3C2A, PIK3CG, LRP1, LRP6, LRP8, KL

Articles related to atherosclerosis:

(show top 50)    (show all 2642)

id	Title	Authors	Year	Affiliating Genes
1	Identification of ADAMTS7 as a novel locus for corona ry atherosclerosis and association of ABO with myocardial infarction in the pre sence of coronary atherosclerosis: two genome-wide association studies. (21239051)	Reilly M.P.... Rader D.J.	2011	ABO, ADAMTS7
2	Association of a fasting glucose genetic risk score w ith subclinical atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study. (21036910)	Rasmussen-Torvik L.J.... Pankow J.S.	2010	GCK, MTNR1B, GCKR
3	Bone mineral density and atherosclerosis: the Multi-E thnic Study of Atherosclerosis, Abdominal Aortic Calcium Study. (19819456)	Hyder J.A.... Criqui M.H.	2010	IL6
4	A polymorphism (G894T) in eNOS increases the risk of coronary atherosclerosis rather than intracranial atherosclerosis in Koreans. (21114134)	Min B.W.... Kim H.S.	2010	NOS3
5	A Translational Medicine perspective of the developme nt of torcetrapib: Does the failure of torcetrapib development cast a shadow on future development of lipid modifying agents, HDL elevation strategies or CETP as a viable molecular target for atherosclerosis? A case study of the use of b iomarkers and Translational Medicine in atherosclerosis drug discovery and deve lopment. (19539799)	Zhao L.... Feuerstein G.	2009	CETP
6	Tissue factor pathway inhibitor, vascular risk factor s and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis. (19467658)	Mitchell C.T.... Cushman M.	2009	TFPI
7	The association between fatal vascular events and ris k factors for carotid atherosclerosis in patients on maintenance hemodialysis: plaque number of dialytic atherosclerosis study. (19281981)	Maeda S.... Hayashi J.	2009	ALB
8	A functional interleukin-1 receptor antagonist polymo rphism influences atherosclerosis development. The interleukin-1beta:interleuki n-1 receptor antagonist balance in atherosclerosis. (19574724)	Olofsson P.S.... SirsjAP A.	2009	IL1B, IL1R1, IL1RN
9	Correlation between the levels of circulating adhesio n molecules and atherosclerosis in type-2 diabetic normotensive patients: circu lating adhesion molecules and atherosclerosis. (19717975)	Rubio-Guerra A.F.... Escalante-Acosta B.A.	2009	ICAM1, VCAM1
10	Sex hormone levels and subclinical atherosclerosis in postmenopausal women: the Multi-Ethnic Study of Atherosclerosis. (18849030)	Ouyang P.... Gapstur S.M.	2009	SHBG
11	Cholesteryl ester transfer protein inhibition, high-density lipoprotein raising, and progression of coronary atherosclerosis: insights from ILLUSTRATE (Investigation of Lipid Level Management Using Coronary Ultrasound to Assess Reduction of Atherosclerosis by CETP Inhibition and HDL Elevation). (19029466)	Nicholls S.J.... Nissen S.E.	2008	CETP
12	Insulin resistance, metabolic syndrome, and subclinical atherosclerosis: the Multi-Ethnic Study of Atherosclerosis (MESA). (17704348)	Bertoni A.G.... Szklo M.	2007	INS
13	Associations between two common polymorphisms in the ABCA1 gene and subclinical atherosclerosis: Multi-Ethnic Study of Atherosclerosis (MESA). (16879828)	Benton J.L.... Post W.	2007	ABCA1
14	Autoimmunity and atherosclerosis: functional polymorphism of PTPN22 is associated with phenotypes related to the risk of atherosclerosis. The Cardiovascular Risk in Young Finns Study. (17223967)	Pertovaara M.... Hurme M.	2007	PTPN22
15	IL-20 is expressed in atherosclerosis plaques and promotes atherosclerosis in apolipoprotein E-deficient mice. (16778121)	Chen W.Y.... Chang M.S.	2006	APOE, IL10, IL20RA
16	Determinants of risk factors of atherosclerosis in the postinfarction period: the Tallinn MI study. (16714248)	Aasvee K.... Baburin A.	2006	APOA1, APOB
17	Analysis of intimal proteoglycans in atherosclerosis-prone and atherosclerosis-resistant human arteries by mass spectrometry. (15970583)	Talusan P.... Stone J.R.	2005	FMOD, NLRP12
18	Comparison of ezetimibe plus simvastatin versus simvastatin monotherapy on atherosclerosis progression in familial hypercholesterolemia. Design and rationale of the Ezetimibe and Simvastatin in Hypercholesterolemia Enhances Atherosclerosis Regression (ENHANCE) trial. (15846260)	Kastelein J.J.... Veltri E.	2005	HMGCR
19	Hormone therapy, C-reactive protein, and progression of atherosclerosis: data from the Estrogen Replacement on Progression of Coronary Artery Atherosclerosis (ERA) trial. (16290959)	Lakoski S.G.... Herrington D.M.	2005	IL6, CRP
20	Effect of intensive lipid lowering on progression of coronary atherosclerosis: evidence for an early benefit from the Reversal of Atherosclerosis with Aggressive Lipid Lowering (REVERSAL) trial. (16126025)	Nissen S.E.	2005	CRP
21	Association of the Lewis genotype with cardiovascular risk factors and subclinical carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) study. (14687237)	Cakir B.... Weston B.W.	2004	FUT3
22	Endothelin-1 and endothelin converting enzyme-1 in human atherosclerosis--novel targets for pharmacotherapy in atherosclerosis. (15320823)	Ihling C.... Loeffler B.M.	2004	ECE1, EDN1
23	Effects of PPARalpha, gamma and delta haplotypes on plasma levels of lipids, severity and progression of coronary atherosclerosis and response to statin therapy in the lipoprotein coronary atherosclerosis study. (15128052)	Chen S.... Marian A.J.	2004	PPARG, PPARA, PPARD
24	Lipaemia, inflammation and atherosclerosis: novel opportunities in the understanding and treatment of atherosclerosis. (15765889)	van Oostrom A.J.... Cabezas M.C.	2004	C3
25	Interleukin-6 promoter polymorphism modulates the effects of heavy alcohol consumption on early carotid artery atherosclerosis: the Carotid Atherosclerosis Progression Study (CAPS). (12574550)	Jerrard-Dunne P.... Markus H.S.	2003	IL6
26	Promoter polymorphism in the endotoxin receptor (CD14) is associated with increased carotid atherosclerosis only in smokers: the Carotid Atherosclerosis Progression Study (CAPS). (12624278)	Risley P.... Markus H.S.	2003	CD14
27	Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis study. (12702517)	Wagenknecht L.E.... Haffner S.M.	2003	INS
28	Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) study. (14505774)	Chambless L.E.... Nieto F.J.	2003	LPA
29	Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis. (14522500)	Ng M.K.... Death A.K.	2003	LIPA
30	Is insulin sensitivity a causal intermediate in the relationship between alcohol consumption and carotid atherosclerosis?: the insulin resistance and atherosclerosis study. (12145245)	Cooper D.E.... Karter A.J.	2002	INS
31	Circulating ICAM-1 (intercellular cell-adhesion molecule 1) is associated with early stages of atherosclerosis development and with inflammatory cytokines in healthy 58-year-old men: the Atherosclerosis and Insulin Resistance (AIR) study. (12149102)	Hulthe J.... Fagerberg B.	2002	ICAM1, TNF, SELE
32	Upregulation of extracellular matrix metalloproteinase inducer (EMMPRIN) and gelatinases in human atherosclerosis infected with Chlamydia pneumoniae: the potential role of Chlamydia pneumoniae infection in the progression of atherosclerosis. (12526080)	Choi E.Y.... Kim H.S.	2002	BSG
33	Apolipoproteins and atherosclerosis. Apolipoprotein E and apolipoprotein(a) as candidate genes of premature development of atherosclerosis. (10984073)	Horejsi B.... Ceska R.	2000	APOE, LPA
34	Serologic and histopathologic study of Chlamydia pneumoniae infection in atherosclerosis: a possible pathogenetic mechanism of atherosclerosis induced by Chlamydia pneumoniae. (10957885)	Song Y.G.... Kim H.S.	2000	MMP9, PTGS2
35	Interactions between angiotensin-I converting enzyme insertion/deletion polymorphism and response of plasma lipids and coronary atherosclerosis to treatment with fluvastatin: the lipoprotein and coronary atherosclerosis study. (10636265)	Marian A.J.... Ballantyne C.M.	2000	ACE
36	Gene therapy for atherosclerosis and atherosclerosis- related diseases. (11122701)	Pakkanen T.... YlAo-Herttuala S.	1999	LIPC
37	Soluble thrombomodulin as a predictor of incident coronary heart disease and symptomless carotid artery atherosclerosis in the Atherosclerosis Risk in Communities (ARIC) Study: a case-cohort study. (10347984)	Salomaa V.... Wu K.K.	1999	THBD
38	Serum sialic acid and sialoglycoproteins in asymptomatic carotid artery atherosclerosis. ARIC Investigators. Atherosclerosis Risk in Communities. (10487488)	Lindberg G.... Burke G.L.	1999	HP
39	Lipoprotein lipase gene mutations, plasma lipid levels, progression/regression of coronary atherosclerosis, response to therapy, and future clinical events. Lipoproteins and Coronary Atherosclerosis Study. (10407505)	Sing K.... Marian A.J.	1999	LPL
40	Effects of lowering average of below-average choleste rol levels on the progression of carotid atherosclerosis: results of the LIPID Atherosclerosis Substudy. LIPID Trial Research Group. (9603532)	MacMahon S.... White H.	1998	APOA1, APOB
41	Circulating adhesion molecules VCAM-1, ICAM-1, and E-selectin in carotid atherosclerosis and incident coronary heart disease cases: the Atherosclerosis Risk In Communities (ARIC) study. (9416885)	Hwang S.J.... Boerwinkle E.	1997	ICAM1, SELE, VCAM1
42	Rationale and design features of a clinical trial examining the effects of cholesterol lowering and angiotensin-converting enzyme inhibition on coronary atherosclerosis: Simvastatin/Enalapril Coronary Atherosclerosis Trial (SCAT). SCAT Investigators. (9215232)	Teo K.K.... Montague T.J.	1997	ACE
43	Retardation of coronary atherosclerosis: the Bezafibrate Coronary Atherosclerosis Intervention Trial (BECAIT) and other angiographic trials. (9211018)	De Faire U.... Hamsten A.	1997	HMGCR
44	Insulin sensitivity and atherosclerosis. The Insulin Resistance Atherosclerosis Study (IRAS) Investigators. (8635260)	Howard G.... Bergman R.	1996	INS
45	Association of fibrinolytic parameters with early atherosclerosis. The ARIC Study. Atherosclerosis Risk in Communities Study. (7805229)	Salomaa V.... Wu K.K.	1995	PLAT, SERPINE1
46	Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography. The Canadian Coronary Atherosclerosis Intervention Trial. (8124836)	Waters D.... LespAcrance J.	1994	HMGCR
47	Associations of lipoprotein cholesterols, apolipoproteins A-I and B, and triglycerides with carotid atherosclerosis and coronary heart disease. The Atherosclerosis Risk in Communities (ARIC) Study. (8018665)	Sharrett A.R.... Davis C.E.	1994	APOA1, APOB
48	Association of hemostatic variables with prevalent cardiovascular disease and asymptomatic carotid artery atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. (8241104)	Folsom A.R.... Davis C.E.	1993	SERPINC1, F3
49	Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study. (8259533)	Conlan M.G.... Wu K.K.	1993	VWF
50	Association of coagulation factors and inhibitors wit h carotid artery atherosclerosis. Early results of the Atherosclerosis Risk in Communities (ARIC) Study. (1342298)	Wu K.K.... Barnes R.	1992	SERPINC1

Genes related to atherosclerosis according to GeneCards:

(show top 50)    (show all 898)

id	Symbol	Description	Score	GeneCards Section Context
1	ALOX5	arachidonate 5-lipoxygenase	11.0	Summaries, Publications
2	ATHS	atherosclerosis susceptibility (lipoprotein associated)	11.0	Publications, Aliases & Descriptions
3	PPARG	peroxisome proliferator-activated receptor gamma	11.0	Summaries, Publications
4	CETP	cholesteryl ester transfer protein, plasma	11.0	Publications, Summaries
5	SELE	selectin E	11.0	Summaries, Publications, UniProt Related, Functions
6	MMP3	matrix metallopeptidase 3 (stromelysin 1, progelatinase)	11.0	Publications, Summaries
7	SOAT1	sterol O-acyltransferase 1	11.0	Publications, Summaries
8	HMGCR	3-hydroxy-3-methylglutaryl-CoA reductase	11.0	Summaries, Publications
9	CCL2	chemokine (C-C motif) ligand 2	11.0	Summaries, Publications, Functions
10	OLR1	oxidized low density lipoprotein (lectin-like) receptor 1	11.0	Functions, Summaries, Publications
11	LPA	lipoprotein, Lp(a)	11.0	Publications, Summaries
12	ABCG8	ATP-binding cassette, sub-family G (WHITE), member 8	11.0	Publications, Summaries
13	PON3	paraoxonase 3	11.0	Summaries, Publications
14	CEL	carboxyl ester lipase (bile salt-stimulated lipase)	11.0	Summaries, Publications
15	GJA4	gap junction protein, alpha 4, 37kDa	11.0	Summaries, Publications
16	ALOX15	arachidonate 15-lipoxygenase	11.0	Summaries, Publications
17	SAA1	serum amyloid A1	11.0	Publications, Summaries
18	ALOX5AP	arachidonate 5-lipoxygenase-activating protein	11.0	Publications, Summaries
19	GSTA4	glutathione S-transferase alpha 4	11.0	Summaries, Publications
20	APOC2	apolipoprotein C-II	11.0	Summaries, Publications
21	MSR1	macrophage scavenger receptor 1	11.0	Summaries, Publications
22	PPARD	peroxisome proliferator-activated receptor delta	11.0	Summaries, Publications
23	NR1H2	nuclear receptor subfamily 1, group H, member 2	11.0	Summaries, Publications
24	NR1H4	nuclear receptor subfamily 1, group H, member 4	11.0	Publications, Summaries
25	CTSK	cathepsin K	11.0	Summaries, Publications
26	CTSL1	cathepsin L1	11.0	Publications, Summaries
27	ALOX12	arachidonate 12-lipoxygenase	11.0	Summaries, Publications
28	NOS1	nitric oxide synthase 1 (neuronal)	11.0	Summaries, Publications
29	PTGIS	prostaglandin I2 (prostacyclin) synthase	11.0	Summaries
30	CDH13	cadherin 13, H-cadherin (heart)	11.0	Publications, Summaries
31	TOR2A	torsin family 2, member A	11.0	Publications, Summaries
32	NR1H3	nuclear receptor subfamily 1, group H, member 3	11.0	Summaries, Publications
33	CTSA	cathepsin A	11.0	Summaries
34	APOA1	apolipoprotein A-I	11.0	Publications
35	APOE	apolipoprotein E	11.0	Publications
36	SUCNR1	succinate receptor 1	11.0	Summaries
37	HSPA12B	heat shock 70kD protein 12B	11.0	Summaries
38	CTSL2	cathepsin L2	11.0	Summaries
39	LPAL2	lipoprotein, Lp(a)-like 2, pseudogene	11.0	Summaries
40	GPBP1	GC-rich promoter binding protein 1	11.0	Summaries
41	CYP7B1	cytochrome P450, family 7, subfamily B, polypeptide 1	11.0	Summaries
42	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
43	LCAT	lecithin-cholesterol acyltransferase	11.0	Publications
44	APOB	apolipoprotein B (including Ag(x) antigen)	11.0	Publications
45	CRP	C-reactive protein, pentraxin-related	11.0	Publications
46	ABCA1	ATP-binding cassette, sub-family A (ABC1), member 1	11.0	Publications
47	LIPC	lipase, hepatic	11.0	Publications
48	MTHFR	methylenetetrahydrofolate reductase (NAD(P)H)	11.0	Publications
49	TLR4	toll-like receptor 4	11.0	Publications
50	ACE	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	11.0	Publications

Pathways related to atherosclerosis according to GeneDecks:

(show top 50)    (show all 203)

id	Pathway	Score	Top Affiliating Genes
1	MAPK Family Pathway36	17.7	VEGFB, BMP2, BMP4, BMP6, RAF1, UTS2
2	MIF Regulation of Innate Immune Cells36	16.9	BMP2, BMP4, BMP6, BCL2, BAX, JUN
3	MIF Mediated Glucocorticoid Regulation36	16.9	BMP2, BMP4, BMP6, BCL2, BAX, CD14
4	all-trans-Retinoic Acid Signaling in Brain36	16.5	BMP2, BMP4, BMP6, BCL2, BAX, CD80
5	IL-6 Pathway36	16.4	BMP2, BMP4, BMP6, RAF1, BAX, CD80
6	cAMP Pathway36	15.8	GCG, VEGFB, BMP2, BMP4, BMP6, RAF1
7	Immune System38	15.0	PDCD1, VCAM1, LILRB1, CIITA, CISH, YWHAZ
8	Toxoplasmosis20	14.8	PIK3CG, MYD88, BCL2, BCL2L1, CIITA, CHUK
9	Chagas disease (American trypanosomiasis)20	14.7	PIK3CG, SERPINE1, MYD88, BDKRB2, CHUK, JUN
10	PPAR Pathway36	14.4	VEGFB, BMP2, BMP4, RAF1, UTS2, ITGA2
11	Rac1 Pathway36	14.3	VEGFB, BMP4, BMP6, RAF1, UTS2, BDNF
12	Regulation of eIF4 and p70S6K36	14.1	BMP2, BMP4, BAX, CD4, CD80, ITGA2
13	Complement and coagulation cascades20	14.0	VWF, SERPINC1, SERPINF2, SERPIND1, SERPINA1, SERPINE1
14	UPA-UPAR Pathway36	13.9	VTN, SERPINE1, LAMA4, JUN, JAK2, ITGA2
15	Immune response IL-1 signaling pathway10	13.8	SERPINE1, MYD88, CHUK, JUN, FOS, IRAK1
16	NF-kappaB Signaling3	13.8	MYD88, CHUK, IRAK1, IL1B, FAS, IKBKB
17	Pertussis20	13.7	MYD88, JUN, CD14, ITGB1, ITGB2, FOS
18	Toll-Like Receptor Signaling Pathways37	13.5	MYD88, CHUK, JUN, CD36, CD14, FOS
19	Immune response MIF in innate immunity response10	13.4	MYD88, CHUK, LBP, JUN, CD14, IRAK1
20	Amoebiasis20	13.4	SERPINB1, LAMA4, CD14, ITGB2, ARG2, ARG1
21	Cell adhesion_ECM remodeling41	13.3	VTN, SERPINE1, VCAN, SDC2, LAMA4, ITGB1
22	Activation of PKC through GPCR36	13.2	VEGFB, BMP2, BMP4, BMP6, RAF1, UTS2
23	Apoptotic Pathways in Synovial Fibroblasts36	13.2	VEGFB, BMP2, BMP4, BMP6, UTS2, BDNF
24	Breast Cancer Regulation by Stathmin136	13.1	VEGFB, BMP2, BMP4, RAF1, UTS2, AXL
25	Angiogenesis3	13.0	REN, VEGFB, CDH5, ITGA6, ITGAV, ITGB1
26	Cell adhesion ECM remodeling10	13.0	VTN, SERPINE1, VCAN, SDC2, LAMA4, ITGB1
27	HMGB1 Pathway36	13.0	JUN, FOS, IL1A, IL1B, IL1R1, IL1R2
28	Inflammasome Activation Pathways37	13.0	MYD88, CHUK, JUN, FOS, IL18, IL1B
29	Blood Coagulation Signaling Pathways37	12.9	VWF, SERPINC1, SERPINF2, SERPIND1, SERPINE1, FGB
30	14-3-3 Induced Apoptosis36	12.6	MYD88, BCL2, CHUK, YWHAZ, JUN, FOS
31	Immune response MIF-mediated glucocorticoid regulation10	12.6	VCAM1, CHUK, JUN, MMP1, FOS, MIF
32	Cytokine production by Th17 cells in CF (Mouse model)41	12.5	MYD88, CHUK, LBP, JAK2, CD14, IL12B
33	PTEN Pathway36	12.5	VEGFB, BMP2, BMP4, UTS2, BDNF, LAMA4
34	Measles20	12.5	PIK3CG, MYD88, CHUK, JAK2, CDKN1B, IRAK1
35	Development_VEGF signaling via VEGFR2 - generic cascades41	12.5	VEGFA, RAF1, JUN, ITGAV, ITGB3, FOS
36	Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics34	12.2	REN, CMA1, BDKRB2, ATP6AP2, MME, MAPK3
37	PDGF Pathway36	12.1	RAF1, CHUK, JUN, JAK2, FOS, MAPK8
38	Development_EGFR signaling pathway41	12.1	RAF1, CHUK, JUN, MMP2, MMP9, FOS
39	ACE Inhibitor Pathway, Pharmacodynamics34	11.4	CMA1, BDKRB2, ATP6AP2, MME, MAPK3, NR3C2
40	Endothelin-1 Signaling Pathway36	INF	BMP2, BMP4, BMP6, RAF1, AXL, CD80
41	Activation of cAMP-Dependent PKA36	INF	GCG, VEGFB, BMP2, BMP4, BMP6, RAF1
42	Ras Pathway36	INF	VEGFB, BMP2, BMP4, RAF1, RALBP1, UTS2
43	14-3-3 Induced Intracellular Signaling36	INF	VEGFB, BMP2, BMP4, RAF1, UTS2, BDNF
44	Activation of PKA through GPCR36	INF	GCG, VEGFB, BMP2, BMP4, BMP6, RAF1
45	JAK-STAT Pathway36	INF	VEGFB, BMP2, BMP4, BMP6, RAF1, UTS2
46	GPCR Pathway36	INF	VEGFB, BMP2, BMP4, BMP6, RAF1, UTS2
47	GSK3 Signaling36	INF	VEGFB, BMP2, BMP4, BMP6, UTS2, BDNF
48	ERK Signaling36	INF	VEGFB, BMP2, BMP4, BMP6, RAF1, UTS2
49	Cytokine-cytokine receptor interaction20	INF	VEGFA, VEGFB, BMP2, LEP, LEPR, CD40LG
50	Antioxidant Action of Vitamin-C36	INF	NCF1, VEGFB, MYO7A, BMP2, BMP4, BMP6

Compounds related to atherosclerosis according to GeneDecks:

(show top 50)    (show all 528)

id	Compound	Score	Top Affiliating Genes
1	phosphotyrosine32	INF	PIK3CG, LRP8, RAF1, CIITA, , JAK2
2	atp32	INF	ZNF202, PIK3C2A, SGCB, VTN, SFTPB, GCK
3	calcium32 9 18 9	44.9	PIK3C2A, PI3, LRP1, LRP5, COG2, KL
4	arachidonic acid32 9 18 9	29.4	CNR1, VWF, SELP, SERPINA1, LPL, LIPF
5	hydrogen32 18	21.8	SGCB, CNR2, SFTPB, PCSK9, GCK, SELPLG
6	glucose32	18.5	KISS1, GCG, GCH1, SERPINA12, SEPP1, LPIN1
7	fenofibrate32 9 9	20.3	PIK3C2A, COG2, RETN, SELE, SELP, SERPINE1
8	tamoxifen32 34 9 9	19.1	VTN, PCNA, SELE, SERPINC1, VEGFA, LPL
9	agarose32	16.0	VWF, SERPINA1, LPA, CLU, CLEC4A, BCL2
10	kininogen32	15.8	REN, VWF, VTN, SELP, SERPINC1, SERPINF2
11	carbohydrates32	15.4	SELE, SELL, SELP, SELPLG, BSG, VCAM1
12	ibmx32	15.2	SGCB, SFTPB, GCG, LPL, VCAM1, BMP2
13	mannitol32 9 9	17.0	GCKR, GCK, SELP, VCAM1, SDHB, XDH
14	formaldehyde32 18	15.9	VWF, PCNA, SELE, SELL, SELP, B2M
15	stearic acid32 9 18 9	17.7	COG2, SELP, LPL, LIPF, LIPG, LIPC
16	groalpha32	14.3	SELE, VCAM1, MMP13, IL10, IL13, IL17A
17	arsenite32 18	15.1	PIK3CG, PCNA, VEGFA, VDR, BCL2, BCL2L1
18	verapamil32 34 9 18 9	17.8	LRP1, REN, UTS2, LDLR, MTTP, JAK2
19	chloroquine32 34 9 9	16.7	VTN, SERPINC1, BMP6, RAF1, CIITA, LDLR
20	nitrate32	13.6	PIK3C2A, SGCB, B2M, CD14, ARG1, IL1R1
21	ptca32	13.4	PIK3C2A, SELP, SERPINF2, SAA4, ITGB2, FGA
22	mg 13232 42	14.3	PIK3CG, PCNA, VDR, BCL2L1, BAX, JUN
23	androstenedione32 18	14.2	COG2, REN, RBP4, SCARB1, LEP, LEPR
24	dihydrotestosterone32 9 18 9	16.2	SERPINE1, LPL, VDR, BMP2, BMP6, CLU
25	lactacystin32	13.2	PIK3CG, SELE, VDR, RAF1, BCL2, BCL2L1
26	irbesartan32 9 9	15.1	COG2, REN, SERPINE1, JUN, MMP9, CCL2
27	gp 13032	13.0	BMP4, BMP6, BCL2L1, LEPR, CISH, JAK2
28	captopril32 42 9 9	15.8	REN, BDKRB2, B2M, CD79A, MMP2, IL1A
29	ifn-alpha32	12.8	CISH, CDKN2A, IL10, IL13, IL17A, IL18
30	ritonavir32 34 9 9	15.7	LPL, UGT1A1, LDLR, CD36, IRS1, INS
31	tirofiban32 9 9	14.7	VWF, VTN, SELP, SERPINC1, P2RY12, CD40LG
32	ionomycin32	12.5	CHUK, CD274, CD40, FOS, IL7R, MAPK3
33	anaphylatoxin32	12.4	MPO, CD59, CD55, IL1B, IL4, IL6
34	levonorgestrel32 9 9	14.3	SERPINC1, MMP1, MMP3, AR, APOA1, APOB
35	tpck32	12.0	PIK3CG, BCL2L1, JUN, IL1B, IL6, IL8
36	nicotine32 34 9 9	14.5	SELL, BMP2, UGT1A1, GPT, CYP2B6, CYP2C19
37	vincristine32 34 9 9	14.5	BCL6, ITGA4, FGF2, ANXA5, MAPK3, F8
38	3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide32	11.4	PCNA, BCL2, BCL2L1, BAX, CD40, MMP2
39	indinavir32 9 9	13.3	LPL, LMNA, UGT1A1, IRS1, APCS, FASN
40	daunorubicin32 9 9	12.8	RAF1, RALBP1, BCL2, BCL2L1, BAX, XDH
41	12-o-tetradecanoylphorbol 13-acetate32	INF	SFTPB, BMP6, RAF1, BCL6, CHUK, MSR1
42	nitric oxide32 9 18 9	INF	LRP8, COG2, KLF2, KLF4, REN, RETN
43	thymidine32 18	INF	KLF4, REG1A, CNR2, SFTPB, PCNA, SERPINA1
44	cholesterol32 9 18 9	INF	ZNF202, PIK3C2A, LRP1, LRP5, LRP8, COG2
45	dmso32	INF	SELP, BMP6, RAG2, BDKRB2, SDHB, S100A9
46	norepinephrine32 9 18 9	INF	PIK3C2A, REN, RETN, CNR1, VWF, GCG
47	pd 98,05932	INF	PIK3CG, KLF4, VTN, GCG, GCLC, SERPINE1
48	carbachol32 9 9	INF	GCG, MAPK10, F2RL1, PTH, CTSB, AHSP
49	l-nmma32	INF	SGCB, VCAM1, BDKRB2, XDH, INSR, IL1RN
50	histidine32	INF	LIPF, CIITA, UGT1A1, MTR, CFH, FURIN

Cellular components related to atherosclerosis according to GeneDecks:

(show all 15)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytosol	GO:005829	INF	PIK3C2A, PIK3CG, NCF1, GCKR, GCK, GCLC
2	cytoplasm	GO:005737	28.0	PIK3C2A, PIK3CG, LRRC18, LRP1, SGCB, PCSK9
3	external side of plasma membrane	GO:009897	15.8	VWF, SELL, SELP, VCAM1, LILRB1, SCNN1A
4	membrane	GO:016020	15.3	PIK3CG, REN, SELPLG, SERPINA9, VLDLR, VEGFA
5	extracellular matrix	GO:031012	13.8	VWF, VTN, SERPINE1, LPL, VCAN, RARRES2
6	platelet alpha granule lumen	GO:031093	13.5	VWF, SERPINF2, SERPINA1, SERPINE1, VEGFA, VEGFB
7	high-density lipoprotein particle	GO:034364	12.9	LIPC, LCAT, SAA1, SAA4, CETP, APOA1
8	membrane raft	GO:045121	12.9	SELE, BSG, SDC4, MS4A2, FURIN, JAK2
9	caveola	GO:005901	12.2	LRP6, LRP8, SELE, SCARB1, JAK2, CDH13
10	very-low-density lipoprotein particle	GO:034361	11.9	VLDLR, VIMP, LPL, APOA1, APOA2, APOA4
11	cell surface	GO:009986	INF	LRP6, KISS1R, PCSK9, VLDLR, VEGFA, LPL
12	integral to plasma membrane	GO:005887	INF	LRP1, KL, SGCB, CNR1, CNR2, SELL
13	extracellular space	GO:005615	INF	KL, REN, VTN, SFTPB, PCSK9, PCSK5
14	plasma membrane	GO:005886	INF	PIK3C2A, PIK3CG, LRP5, LRP6, LRP8, KL
15	extracellular region	GO:005576	INF	LRP8, KL, REG1A, RETN, KISS1, VWF

Biological processes related to atherosclerosis according to GeneDecks:

(show top 50)    (show all 75)

id	Name	GO ID	Score	Top Affiliating Genes
1	blood coagulation	GO:007596	20.9	PIK3CG, LRP8, VWF, SELL, SELP, SELPLG
2	immune response	GO:006955	17.9	CNR2, VTN, BMP6, CIITA, CHIT1, CHUK
3	lipid metabolic process	GO:006629	17.6	ZNF202, LRP8, LPA, LPIN2, LPL, LIPG
4	positive regulation of transcription from RNA polymerase II promoter	GO:045944	17.5	LRP5, LRP6, KLF2, KLF4, SERPINF2, SERPINE1
5	platelet activation	GO:030168	17.2	PIK3CG, VWF, SELP, SERPINF2, SERPINA1, SERPINE1
6	G-protein coupled receptor signaling pathway	GO:007186	16.9	PIK3CG, KISS1, KISS1R, GCG, BDKRB2, KCNK2
7	cell-cell signaling	GO:007267	16.2	KLF10, PCSK5, NAMPT, BMP2, S100A9, CD86
8	cell adhesion	GO:007155	16.1	VWF, VTN, SELL, SELP, SELPLG, LPP
9	response to lipopolysaccharide	GO:032496	15.9	CNR1, CNR2, SFTPB, GCH1, SELE, SELP
10	chemotaxis	GO:006935	15.1	SERPIND1, RALBP1, S100A8, S100A9, FGF2, IL4
11	positive regulation of apoptotic process	GO:043065	15.0	LRP6, CNR1, BMP2, BMP4, LILRB1, CLU
12	positive regulation of angiogenesis	GO:045766	15.0	SERPINE1, VEGFA, UTS2, UTS2R, CHI3L1, MMP9
13	platelet degranulation	GO:002576	14.8	VWF, SELP, SERPINF2, SERPINA1, SERPINE1, VEGFA
14	negative regulation of apoptotic process	GO:043066	14.6	PIK3CG, GCG, SERPINE1, VEGFA, BMP4, RAF1
15	xenobiotic metabolic process	GO:006805	14.6	GCLC, GCLM, NAT2, UGT1A1, MTR, S100A12
16	lipoprotein metabolic process	GO:042157	14.6	PCSK9, LPA, LPL, SCARB1, LDLR, LCAT
17	cell surface receptor signaling pathway	GO:007166	14.4	BSG, MYD88, CLEC4A, BDKRB2, LEPR, CD36
18	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	14.4	MYD88, CHUK, S100A12, CD36, CD40, IRAK1
19	aging	GO:007568	14.3	KL, CNR1, VDR, VCAM1, SCAP, UCP3
20	leukocyte migration	GO:050900	14.2	SELL, SELP, SELPLG, BSG, ITGA4, ITGA6
21	anti-apoptosis	GO:006916	14.1	GCLC, VIMP, VEGFB, MYD88, PAFAH2, BDNF
22	angiogenesis	GO:001525	13.9	PIK3CG, SERPINE1, VEGFA, S1PR1, ATP5B, JUN
23	response to glucocorticoid stimulus	GO:051384	13.7	SFTPB, SERPINE1, BGLAP, UCP3, LCAT, INSR
24	positive regulation of smooth muscle cell proliferation	GO:048661	13.6	SERPINF2, MYD88, BMP4, S1PR1, JUN, CDH13
25	cholesterol efflux	GO:033344	13.6	SCARB1, APOA1, APOA2, APOA4, APOC1, APOC2
26	positive regulation of NF-kappaB transcription factor activity	GO:051092	13.6	MYD88, CLU, CHUK, CD40, IRAK1, AR
27	triglyceride metabolic process	GO:006641	13.5	PCSK9, LPL, LIPF, CEL, CETP, INSIG1
28	cellular response to lipopolysaccharide	GO:071222	13.4	SERPINE1, VLDLR, VIMP, LILRB1, LBP, AXL
29	response to organic cyclic compound	GO:014070	13.4	SELP, SERPINA1, BMP4, UGT1A1, JUN, CDKN1A
30	positive regulation of inflammatory response	GO:050729	13.0	SERPINE1, JAK2, IL12B, IL15, IL18, IL2
31	lipopolysaccharide-mediated signaling pathway	GO:031663	13.0	MYD88, SCARB1, LBP, IRAK1, IL18, IL1B
32	positive regulation of nitric oxide biosynthetic process	GO:045429	12.9	JAK2, INS, INSR, IL1B, IFNG, ICAM1
33	positive regulation of phosphatidylinositol 3-kinase cascade	GO:014068	12.7	SELP, JAK2, FLT1, INS, ANGPT1, CCL5
34	negative regulation of inflammatory response	GO:050728	12.7	KLF4, CNR2, SERPINC1, VIMP, SAA1, FEM1A
35	wound healing	GO:042060	12.7	RAF1, SDC2, SCARB1, S100A8, ITGB3, FMOD
36	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	12.3	LRP8, VTN, VEGFA, VEGFB, JAK2, CD36
37	female pregnancy	GO:007565	12.0	PAPPA, BCL2, LEP, FLT1, IL1RN, IL4
38	innate immune response	GO:045087	INF	PIK3CG, NCF1, MYD88, CLU, CLEC4A, BCL2
39	cholesterol homeostasis	GO:042632	INF	LRP5, PCSK9, LIPG, LIPC, SCARB1, LDLR
40	response to drug	GO:042493	INF	REN, GCLM, VLDLR, LPL, UTS2, UTS2R
41	response to ethanol	GO:045471	INF	CNR1, RBP4, BGLAP, BCL2, LCT, S100A8
42	positive regulation of ERK1 and ERK2 cascade	GO:070374	INF	GCG, SERPINF2, VEGFB, BMP2, BMP4, CHI3L1
43	positive regulation of cell migration	GO:030335	INF	VEGFA, BMP2, S1PR1, FURIN, JAK2, CDH13
44	regulation of blood pressure	GO:008217	INF	LRP5, REN, GCH1, UTS2, LEP, GNB3
45	response to hypoxia	GO:001666	INF	SFTPB, SERPINA1, VEGFA, VCAM1, MYOCD, BMP2
46	cholesterol metabolic process	GO:008203	INF	PCSK9, VLDLR, LIPC, SCAP, LEP, LEPR
47	negative regulation of cell proliferation	GO:008285	INF	KLF10, KLF4, KISS1R, VDR, MYOCD, BMP2
48	signal transduction	GO:007165	INF	LRP8, PDCD1, GCG, VLDLR, NAMPT, LPXN
49	positive regulation of cell proliferation	GO:008284	INF	LRP5, REG1A, NAMPT, VEGFA, MYOCD, BCL2L1
50	inflammatory response	GO:006954	INF	PIK3CG, CNR2, SELE, SELP, MYD88, BMP2

Molecular functions related to atherosclerosis according to GeneDecks:

(show all 13)

id	Name	GO ID	Score	Top Affiliating Genes
1	protein binding	GO:005515	INF	GAS6, GATA2, HGF, HDAC3, ADIPOQ, ADAM17
2	protein homodimerization activity	GO:042803	INF	EPHX2, ADIPOQ, ADH7, ADD1, ADRB2, ADAM10
3	heparin binding	GO:008201	15.9	CCL15, LPL, LPA, VEGFB, VEGFA, SERPIND1
4	cytokine activity	GO:005125	14.8	IL1B, BMP6, BMP4, BMP2, VEGFA, NAMPT
5	protein heterodimerization activity	GO:046982	14.6	HGF, ADIPOR1, ADD1, ADORA2A, PDGFB, PDGFA
6	growth factor activity	GO:008083	14.2	IL6, BDNF, BMP6, BMP4, BMP2, VEGFB
7	heme binding	GO:020037	13.4	HBB, CYBA, CYP2C8, CYP2E1, CYP2C19, CYP2B6
8	chemokine activity	GO:008009	13.4	PPBP, PF4, CX3CL1, CXCL1, CXCL10, CXCL12
9	eukaryotic cell surface binding	GO:043499	12.8	ANXA5, PDGFA, PDGFB, HBEGF, THBS1, TGFB1
10	cholesterol binding	GO:015485	12.7	CRP, ABCA1, ABCG1, TSPO, SOAT1, SOAT2
11	enzyme binding	GO:019899	11.7	CYP2E1, CYP2C19, PTPN1, PTGS2, DYM, TP53
12	protease binding	GO:002020	11.7	IL1R1, F3, TP53, TNF, TNFAIP3, TNFRSF1A
13	receptor binding	GO:005102	INF	TNFSF10, CCL13, CCL2, CCL15, ANGPTL4, ANGPT2