MCID: ATH003
MIFTS: 68

Atherosclerosis malady

Cardiovascular diseases category
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Summaries for Atherosclerosis

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34MedlinePlus, 65Wikipedia, 33MalaCards
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MedlinePlus:34 Atherosclerosis is a disease in which plaque builds up inside your arteries. plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. over time, plaque hardens and narrows your arteries. that limits the flow of oxygen-rich blood to your body. atherosclerosis can lead to serious problems, including coronary artery disease. these arteries supply blood to your heart. when they are blocked, you can suffer angina or a heart attack. carotid artery disease. these arteries supply blood to your brain. when they are blocked you can suffer a stroke. peripheral arterial disease. these arteries are in your arms, legs and pelvis. when they are blocked, you can suffer from numbness, pain and sometimes infections. atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. many people don't know they have it until they have a medical emergency. a physical exam, imaging, and other diagnostic tests can tell if you have it. medicines can slow the progress of plaque buildup. your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. lifestyle changes can also help. these include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. nih: national heart, lung, and blood institute

MalaCards: Atherosclerosis, also known as atherosclerosis, susceptibility to, is related to insulin resistance and hypertension. An important gene associated with Atherosclerosis is ALOX5 (arachidonate 5-lipoxygenase), and among its related pathways are Development VEGF signaling and activation and G protein signaling Ras family GTPases in kinase cascades scheme . The compounds bay-x 1005 and bw-b 70c have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and monocytes, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:65 Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of... more...

Aliases & Classifications for Atherosclerosis

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Sources:
8Disease Ontology, 9diseasecard, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 62UMLS, 58SNOMED-CT, 35MeSH, 27ICD9CM, 40NCIt, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

atherosclerosis 8 47 10 45 34 62
atherosclerosis, susceptibility to 9


External Ids:

Disease Ontology8 DOID:1936
MeSH35 D050197
ICD9CM27 440
NCIt40 C35768
ICD1025 I70

Related Diseases for Atherosclerosis

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Atherosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.5SOAT1, HMGCR, CCL2, PPARG, LPA, SAA1
2hypertension31.4CCL2, PPARG, LPA, OLR1, SELE
3hypercholesterolemia31.3LPA, HMGCR, ABCG8, SOAT1, SELE, OLR1
4obesity31.2PPARG, CCL2, MMP3, SELE, LPA, SOAT1
5coronary artery disease31.2OLR1, HMGCR, LPA
6diabetes mellitus31.2LPA, ALOX12, MMP3, SELE, PPARG, CCL2
7familial hypercholesterolemia31.1LPA, SOAT1, HMGCR
8arthritis31.1MMP3, SELE, CCL2, ALOX12, ALOX15, HMGCR
9myocardial infarction31.1ESR1, OLR1
10systemic lupus erythematosus31.0ALOX5, SELE, CCL2, MMP3
11rheumatoid arthritis31.0LPA, SELE, SAA1, CCL2, ALOX12, HMGCR
12type 2 diabetes mellitus30.9LPA, SELE, PPARG, HMGCR, ALOX12, CCL2
13hyperhomocysteinemia30.9LPA, SELE, CCL2
14arteriosclerosis30.8PPARG, CCL2, HMGCR
15vascular disease30.7ESR1, MMP3
16alzheimer's disease30.7PPARG, SOAT1, ALOX5, OLR1, HMGCR, LPA
17hyperglycemia30.6LPA, PPARG, ALOX12, HMGCR, SELE
18coronary stenosis30.6LPA, OLR1
19ischemia30.6OLR1, ALOX5, MMP3, HMGCR, SOAT1, SELE
20peripheral vascular disease30.6SELE, CCL2
21hypertriglyceridemia30.6PPARG, HMGCR, LPA, SELE, ATHS
22acute myocardial infarction30.5LPA, SAA1, SELE, OLR1, HMGCR
23psoriatic arthritis30.4MMP3, SELE
24hyperlipidemia type 330.4LPA, HMGCR
25tangier disease30.3PPARG, LPA
26osteoporosis30.3MMP3, ESR1, ALOX5, ALOX15, HMGCR
27kawasaki disease30.2CCL2, MMP3, SELE
28sitosterolemia30.2ABCG8, HMGCR
29diabetic nephropathy30.2PPARG, CCL2, HMGCR, LPA
30psoriasis30.2ALOX12, SELE, CCL2, ALOX5
31asthma30.2CCL2, ALOX12, ALOX5, SELE, ALOX15, MMP3
32proteinuria30.1ALOX5, CCL2, LPA, OLR1, HMGCR
33colon cancer30.1MMP3, PPARG, SELE, HMGCR, ALOX5
34cerebrovascular disease30.1ALOX5, HMGCR, PON3, OLR1, LPA, ALOX12
35abdominal aortic aneurysm30.0CCL2, MMP3
36endometriosis30.0HMGCR, CCL2, MMP3, ESR1
37prostate cancer30.0SOAT1, ALOX15, ESR1, ALOX5, PPARG, ALOX12
38osteoarthritis29.9OLR1, CCL2, ALOX5, MMP3, SAA1
39congenital heart disease29.9LPA, HMGCR, MMP3
40glomerulonephritis29.9LPA, ALOX5, CCL2
41liver cirrhosis29.8LPA, MMP3, ALOX5
42aortic atherosclerosis11.0
43endotheliitis10.9
44cerebritis10.9
45cerebral atherosclerosis10.9
46artery disease10.7
47lupus erythematosus10.6
48hepatitis10.5
49generalized atherosclerosis10.5
50periodontitis10.5

Graphical network of the top 20 diseases related to Atherosclerosis:



Diseases related to atherosclerosis

Symptoms for Atherosclerosis

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Drugs & Therapeutics for Atherosclerosis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Atherosclerosis

Search NIH Clinical Center for Atherosclerosis

Genetic Tests for Atherosclerosis

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Anatomical Context for Atherosclerosis

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Sources:
31LifeMap Discovery™, 33MalaCards
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MalaCards organs/tissues related to Atherosclerosis:

33
Heart, Endothelial, Monocytes, Smooth muscle, Kidney, Testes, Brain, Liver, Lung, T cells, Bone, Myeloid, Ovary, Adipocyte, B cells, Pancreas, Prostate, Skin, Thyroid, Colon, Spinal cord, Placenta, Pituitary, Lymph node, Eye, Retina, Skeletal muscle, Globus pallidus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 EndotheliumArteriesArterial Endothelial Cells Potential therapeutic candidate, affected by disease
2 HeartCoronary Capillary Plexus  Affected by disease
3 HeartCoronary Vessels  Affected by disease

Animal Models for Atherosclerosis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Atherosclerosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2ALOX15, CCL2, ESR1, SOAT1, PPARG
2MP:000539710.0SOAT1, SELE, ABCG8, PPARG, ESR1, MMP3
3MP:000538510.0PPARG, SELE, SOAT1, ESR1, CCL2, ALOX5
4MP:000538710.0ESR1, SOAT1, SELE, PPARG, MMP3, CCL2
5MP:00107719.9PPARG, SELE, SOAT1, ESR1, CCL2, ALOX12
6MP:00053769.9OLR1, PPARG, ABCG8, SELE, SOAT1, PON3
7MP:00053709.8PPARG, ABCG8, SELE, SOAT1, ESR1, CCL2

Publications for Atherosclerosis

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Sources:
52PubMed
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Articles related to Atherosclerosis:

(show top 50)    (show all 4295)
idTitleAuthorsYear
1
Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. (24401215)
2014
2
Acromegaly and oxidative stress: impact on endothelial dysfunction and atherosclerosis. (23608960)
2013
3
Carotid Artery Intima Media Thickness and HsCRP; Predictors for Atherosclerosis in Prediabetic Patients? (24353563)
2013
4
Task force on: 'Early markers of atherosclerosis: influence of age and sex'. (24335886)
2013
5
Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. (24324141)
2013
6
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. (21497768)
2011
7
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. (21220246)
2011
8
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
9
A genome-wide association study of carotid atherosclerosis in HIV-infected men. (20009918)
2010
10
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
11
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (19878569)
2009
12
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis. (19126404)
2009
13
Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. (19205907)
2009
14
Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. (18243217)
2008
15
C-reactive protein and homocysteine as risk factors of atherosclerosis]. (18853656)
2008
16
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
17
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
18
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. (19330073)
2008
19
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults. (17205961)
2007
20
Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. (17591977)
2007
21
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. (17495603)
2007
22
Insulin resistance and atherosclerosis. (16823479)
2006
23
Cyclooxygenase-2 and atherosclerosis: disputation and prospect]. (16626567)
2006
24
Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. (16741184)
2006
25
Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant. (16794232)
2006
26
Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. (15802632)
2005
27
Pregnancy associated plasma protein-A and coronary atherosclerosis: marker, friend, or foe? (16141260)
2005
28
Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice. (14739122)
2004
29
Effects of ethanol on lipids and atherosclerosis. (15006415)
2004
30
Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. (15215180)
2004
31
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. (15178561)
2004
32
Antibodies to oxidized LDL in atherosclerosis development--clinical and animal studies. (15369729)
2004
33
Dissection and atherosclerosis of carotid arteries in the young: role of the apolipoprotein E polymorphism. (11784371)
2002
34
The magnitude of the immune response to heat shock protein-65 following BCG immunisation is associated with the extent of experimental atherosclerosis. (12417273)
2002
35
A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. (11257277)
2001
36
The role of fibric acids in atherosclerosis. (11123853)
2001
37
Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis. (11705704)
2001
38
High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis. (11209972)
2000
39
Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. (10488958)
1999
40
Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. (9614622)
1998
41
Heat-shock protein 65 and atherosclerosis in patients on regular hemodialysis. (9678443)
1998
42
Proposed synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis. (9642484)
1998
43
Components of the insulin resistance syndrome are associated with progression of atherosclerosis in non-grafted arteries 5 years after coronary artery bypass surgery. (9717003)
1998
44
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. (9312550)
1997
45
Hypertension and atherosclerosis. (8872835)
1996
46
Plasma apolipoproteins B and AI in healthy individuals and patients with coronary atherosclerosis in a male population from Lithuania]. (1753578)
1991
47
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
48
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
49
Cerebral atherosclerosis; a correlative study between physical and psychological pictures. (5478383)
1970
50
Effect of choline in the prevention of experimental aortic atherosclerosis. (18878120)
1948

Variations for Atherosclerosis

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Expression for genes affiliated with Atherosclerosis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atherosclerosis

Search GEO for disease gene expression data for Atherosclerosis.

Pathways for genes affiliated with Atherosclerosis

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Sources:
50PathCards, 60Thomson Reuters, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 51PharmGKB
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Pathways related to Atherosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades60
10.3SELE, ESR1, CCL2
2
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
10.3CCL2, MMP3, PPARG
310.3CCL2, MMP3, SELE
4
Show member pathways
thioredoxin pathway38
10.3ALOX5, CCL2, SAA1
5
Show member pathways
10.3ALOX12, ALOX5, ALOX15
6
Show member pathways
aspirin triggered resolvin E biosynthesis38
10.3ALOX15, ALOX5, ALOX12
7
Show member pathways
10.3ABCG8, SOAT1, HMGCR
8
Show member pathways
10.0PPARG, ABCG8, PON3, LPA, ALOX12, ALOX5

Compounds for genes affiliated with Atherosclerosis

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Sources:
61Tocris Bioscience, 45Novoseek, 29IUPHAR, 51PharmGKB, 11DrugBank, 24HMDB, 3BitterDB
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Compounds related to Atherosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1bay-x 10056110.7ALOX5, ALOX15, ALOX12
2bw-b 70c6110.7ALOX15, ALOX5, ALOX12
313-hpode4510.7ALOX12, ALOX15, ALOX5
4mk 88661 4511.7ALOX12, ALOX5, ALOX15, PPARG
515-hydroxyeicosatetraenoic acid4510.7ALOX5, ALOX15, ALOX12
6sulfasalazine29 45 51 1113.6MMP3, ALOX5, PPARG, SELE, CCL2
7fenofibric acid45 2911.6HMGCR, PPARG, CCL2
8sitosterol4510.6SOAT1, HMGCR, ABCG8
9probucol45 1111.6CCL2, SELE, HMGCR, SOAT1
10quinacrine45 1111.6ALOX12, ALOX5, MMP3, SELE
11ndga4510.6ALOX12, MMP3, ALOX5, PPARG
12fenofibrate45 51 1112.6PPARG, LPA, SELE, CCL2, HMGCR, OLR1
13bezafibrate45 29 1112.6PPARG, HMGCR, SOAT1, LPA
14troglitazone45 29 61 1113.6HMGCR, CCL2, MMP3, SELE, PPARG
15adma4510.6CCL2, OLR1, SELE
16prostacyclin4510.6HMGCR, ALOX5, ALOX12, CCL2, SELE, PPARG
17ibuprofen45 29 51 24 1114.6MMP3, ALOX12, PPARG, ALOX5
18linoleic acid29 45 2412.6ALOX15, PPARG, ALOX12, ALOX5, OLR1
19aspirin45 51 29 2413.6SELE, LPA, PPARG, ALOX5, HMGCR, ALOX12
20celecoxib45 61 29 51 24 1115.6HMGCR, PPARG, ALOX5, MMP3
21pravastatin45 51 29 24 1114.5PPARG, OLR1, CCL2, LPA, MMP3, SELE
22zileuton45 61 29 1113.5ALOX15, ALOX5, ALOX12
23histamine45 29 2412.5MMP3, SELE, CCL2, ALOX5, HMGCR, OLR1
24baicalein45 6111.5ALOX5, ALOX15, ALOX12
25losartan45 51 29 1113.5SELE, PPARG, CCL2, OLR1
26genistein45 29 61 3 24 1115.5ALOX12, CCL2, MMP3, ESR1, PPARG, ALOX5
27n acetylcysteine4510.5CCL2, SELE, PPARG, SOAT1, MMP3, ALOX5
28pge24510.5MMP3, ALOX15, ALOX12, PPARG, ALOX5, SELE
29piroxicam45 1111.5MMP3, SAA1, ALOX12
30simvastatin45 51 61 29 24 1115.5CCL2, HMGCR, PPARG, SELE, OLR1, SAA1
31actinomycin d4510.5LPA, SELE, SOAT1, CCL2, ESR1, HMGCR
32atorvastatin45 51 29 24 1114.5SOAT1, LPA, CCL2, OLR1, HMGCR, SELE
33phosphatidylcholine4510.4ALOX5, CCL2, LPA, SOAT1, ALOX15, SELE
34rofecoxib45 51 29 1113.4MMP3, PPARG, ALOX5
35dexamethasone45 51 29 1113.4ALOX12, SOAT1, CCL2, PPARG, MMP3, ALOX5
36cycloheximide4510.4ALOX12, ALOX5, HMGCR, SOAT1, PPARG, ESR1
37indomethacin45 29 61 1113.4OLR1, MMP3, ALOX5, ALOX12, PPARG
38sb 20358045 6111.4SELE, MMP3, ALOX5, PPARG, CCL2
39arginine4510.4SAA1, LPA, OLR1, HMGCR, SOAT1, ALOX5
40estrogen4510.4ESR1, ALOX12, PPARG, SOAT1, LPA, SAA1
41vegf4510.3HMGCR, ESR1, SOAT1, SELE, LPA, ALOX12
42nitric oxide45 24 1112.3ALOX12, CCL2, LPA, SELE, ALOX15, OLR1
43glucose4510.3OLR1, MMP3, SOAT1, PPARG, ALOX12, ABCG8
44gamma-linolenic acid45 2411.3ALOX5, ALOX15, PPARG
45cholesterol45 29 24 1113.2HMGCR, PPARG, PON3, ABCG8, ATHS, SELE
46vitamin d4510.2MMP3, ALOX5, CCL2, PPARG
47fibrinogen4510.2SOAT1, SAA1, LPA, CCL2, SELE
48lipid4510.1ALOX15, ALOX12, LPA, SAA1, MMP3, SOAT1
49oxygen45 2411.1MMP3, ALOX12, ALOX5, ALOX15, OLR1, CCL2
505 aminosalicylic acid4510.0ALOX5, CCL2, PPARG

GO Terms for genes affiliated with Atherosclerosis

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16Gene Ontology
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Cellular components related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:01602010.1OLR1, ALOX15, ALOX12, ESR1, SOAT1

Biological processes related to Atherosclerosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoxin A4 biosynthetic processGO:200130310.6ALOX15, ALOX12
2lipoxin metabolic processGO:200130010.6ALOX5, ALOX12
3hepoxilin biosynthetic processGO:05112210.6ALOX12, ALOX15
4lipoxygenase pathwayGO:01937210.6ALOX15, ALOX5, ALOX12
5lymphocyte chemotaxisGO:04824710.6CCL2, SAA1
6arachidonic acid metabolic processGO:01936910.6ALOX15, ALOX5, ALOX12
7response to nutrientGO:00758410.5PPARG, ABCG8, HMGCR
8fatty acid oxidationGO:01939510.5ALOX12, PPARG
9inflammatory responseGO:00695410.4SELE, CCL2, ALOX15, OLR1
10macrophage chemotaxisGO:04824610.4CCL2, SAA1
11agingGO:00756810.4CCL2, ALOX12, HMGCR
12leukotriene metabolic processGO:00669110.4ALOX5, ALOX15
13leukocyte cell-cell adhesionGO:00715910.4OLR1, SELE
14cholesterol effluxGO:03334410.0SOAT1, ABCG8
15small molecule metabolic processGO:04428110.0ABCG8, LPA, ALOX12, ALOX5, ALOX15, HMGCR

Molecular functions related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1iron ion bindingGO:00550610.3ALOX15, ALOX5, ALOX12
2arachidonate 12-lipoxygenase activityGO:00405210.0ALOX15, ALOX12

Products for genes affiliated with Atherosclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atherosclerosis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet