MCID: ATH003
MIFTS: 65

Atherosclerosis malady

Cardiovascular diseases category

Summaries for Atherosclerosis

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MedlinePlus:34 Atherosclerosis is a disease in which plaque builds up inside your arteries. plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. over time, plaque hardens and narrows your arteries. that limits the flow of oxygen-rich blood to your body. atherosclerosis can lead to serious problems, including coronary artery disease. these arteries supply blood to your heart. when they are blocked, you can suffer angina or a heart attack. carotid artery disease. these arteries supply blood to your brain. when they are blocked you can suffer a stroke. peripheral arterial disease. these arteries are in your arms, legs and pelvis. when they are blocked, you can suffer from numbness, pain and sometimes infections. atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. many people don't know they have it until they have a medical emergency. a physical exam, imaging, and other diagnostic tests can tell if you have it. medicines can slow the progress of plaque buildup. your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. lifestyle changes can also help. these include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. nih: national heart, lung, and blood institute

MalaCards based summary: Atherosclerosis, also known as atherosclerosis, susceptibility to, is related to coronary artery disease and obesity. An important gene associated with Atherosclerosis is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are G protein signaling Ras family GTPases in kinase cascades scheme and TNF signaling pathway. The compounds bay-x 1005 and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and monocytes, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Wikipedia:65 Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of... more...

Aliases & Classifications for Atherosclerosis

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Atherosclerosis, Aliases & Descriptions:

Name: Atherosclerosis 32 10 12 45 34 62
 
Atherosclerosis, Susceptibility to 11


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology10 DOID:1936
ICD9CM29 440
MeSH35 D050197
NCIt40 C35768
ICD1027 I70

Related Diseases for Atherosclerosis

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Diseases related to Atherosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 342)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease31.2LPA, HMGCR, OLR1
2obesity31.1ALOX5, PPARG, CCL2, LPA, MMP3, SELE
3myocardial infarction31.0LPA, HMGCR, GJA4, SAA1, OLR1
4systemic lupus erythematosus31.0CCL2, MMP3, ALOX5, SELE
5arthritis31.0ALOX5, CTSL, CCL2, ALOX15, MMP3, HMGCR
6rheumatoid arthritis30.9LPA, SELE, SAA1, MMP3, CCL2, ALOX12
7hyperhomocysteinemia30.8SELE, LPA, CCL2
8aneurysm30.8CTSL, ALOX5, MMP3
9arteriosclerosis30.8CCL2, PPARG, HMGCR
10vascular disease30.8OLR1, HMGCR, CTSL, ALOX12, CCL2, LPA
11coronary stenosis30.6OLR1, LPA
12hypertriglyceridemia30.5SELE, HMGCR, LPA, ATHS, PPARG
13hyperglycemia30.5ALOX12, LPA, HMGCR, SELE, PPARG
14ischemia30.5SELE, HMGCR, OLR1, SOAT1, MMP3, ALOX5
15acute myocardial infarction30.5HMGCR, LPA, SAA1, SELE, OLR1
16peripheral vascular disease30.5SELE, CCL2
17psoriatic arthritis30.3SELE, MMP3
18hyperlipidemia type 330.3HMGCR, LPA
19sitosterolemia30.3HMGCR, ABCG8
20tangier disease30.2LPA, PPARG
21osteoporosis30.2MMP3, HMGCR, CTSL, ALOX5, ALOX15
22asthma30.2ALOX12, SELE, ALOX15, ALOX5, CCL2, MMP3
23kawasaki disease30.2CCL2, MMP3, SELE
24psoriasis30.1ALOX5, CCL2, CTSL, SELE, ALOX12
25abdominal aortic aneurysm30.0CCL2, CTSL, MMP3
26proteinuria30.0OLR1, CTSL, HMGCR, LPA, CCL2, ALOX5
27prostate cancer30.0ALOX12, CTSL, ALOX15, SOAT1, PPARG, ALOX5
28hypercholesterolemia, familial29.8LPA, SOAT1, HMGCR
29glomerulonephritis29.8LPA, CCL2, ALOX5
30congenital heart disease29.8MMP3, HMGCR, LPA
31endometriosis29.8MMP3, HMGCR, CCL2
32osteoarthritis29.8MMP3, CTSL, OLR1, ALOX5, CCL2, SAA1
33alzheimer disease29.8CTSL, HMGCR, OLR1, LPA, ALOX5, SOAT1
34aortic atherosclerosis11.0
35endotheliitis10.9
36cerebritis10.9
37cerebral atherosclerosis10.9
38artery disease10.8
39lupus erythematosus10.6
40hepatitis10.5
41generalized atherosclerosis10.5
42periodontitis10.5
43uremia10.4
44kidney disease10.4
45liver disease10.4
46fatty liver disease10.4
47pneumonia10.4
48atrial fibrillation10.4
49ischemic heart disease10.3
50peripheral artery disease10.3

Graphical network of the top 20 diseases related to Atherosclerosis:



Diseases related to atherosclerosis

Symptoms for Atherosclerosis

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Drugs & Therapeutics for Atherosclerosis

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Drug clinical trials:

Search ClinicalTrials for Atherosclerosis

Search NIH Clinical Center for Atherosclerosis

Genetic Tests for Atherosclerosis

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Anatomical Context for Atherosclerosis

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MalaCards organs/tissues related to Atherosclerosis:

33
Heart, Endothelial, Monocytes, Smooth muscle, Kidney, Testes, Brain, T cells, Lung, Liver, Bone, Neutrophil, Adipocyte, Ovary, Myeloid, Thyroid, B cells, Colon, Pancreas, Skin, Prostate, Spinal cord, Bone marrow, Eye, Lymph node, Retina, Skeletal muscle, Placenta, Globus pallidus, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 EndotheliumArteriesArterial Endothelial Cells Potential therapeutic candidate, affected by disease
2 HeartCoronary Capillary Plexus  Affected by disease
3 HeartCoronary Vessels  Affected by disease

Animal Models for Atherosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Atherosclerosis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.6CTSL, CCL2, SOAT1, SELE, ABCG8, PPARG
2MP:00053859.3PPARG, SELE, SOAT1, CCL2, ALOX5, ALOX15
3MP:00107719.1PPARG, SELE, SOAT1, CCL2, ALOX12, ALOX15
4MP:00053979.1SOAT1, SELE, ABCG8, PPARG, MMP3, CCL2
5MP:00053879.1MMP3, SOAT1, SELE, PPARG, CCL2, ALOX12
6MP:00053768.9CTSL, PPARG, ABCG8, SELE, SOAT1, PON3

Publications for Atherosclerosis

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Articles related to Atherosclerosis:

(show top 50)    (show all 4437)
idTitleAuthorsYear
1
Psychosocial Predictors of Metabolic Syndrome among Latino Groups in the Multi-Ethnic Study of Atherosclerosis (MESA). (25906072)
2015
2
Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. (25392271)
2014
3
Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. (24401215)
2014
4
Acromegaly and oxidative stress: impact on endothelial dysfunction and atherosclerosis. (23608960)
2013
5
Carotid Artery Intima Media Thickness and HsCRP; Predictors for Atherosclerosis in Prediabetic Patients? (24353563)
2013
6
Task force on: 'Early markers of atherosclerosis: influence of age and sex'. (24335886)
2013
7
Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. (24324141)
2013
8
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. (21497768)
2011
9
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
10
A genome-wide association study of carotid atherosclerosis in HIV-infected men. (20009918)
2010
11
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
12
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (19878569)
2009
13
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis. (19126404)
2009
14
Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. (19205907)
2009
15
Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. (18243217)
2008
16
C-reactive protein and homocysteine as risk factors of atherosclerosis]. (18853656)
2008
17
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
18
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
19
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. (19330073)
2008
20
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults. (17205961)
2007
21
Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. (17591977)
2007
22
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. (17495603)
2007
23
Insulin resistance and atherosclerosis. (16823479)
2006
24
Cyclooxygenase-2 and atherosclerosis: disputation and prospect]. (16626567)
2006
25
Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. (16741184)
2006
26
Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant. (16794232)
2006
27
Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. (15802632)
2005
28
Pregnancy associated plasma protein-A and coronary atherosclerosis: marker, friend, or foe? (16141260)
2005
29
Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice. (14739122)
2004
30
Effects of ethanol on lipids and atherosclerosis. (15006415)
2004
31
Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. (15215180)
2004
32
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. (15178561)
2004
33
Antibodies to oxidized LDL in atherosclerosis development--clinical and animal studies. (15369729)
2004
34
Dissection and atherosclerosis of carotid arteries in the young: role of the apolipoprotein E polymorphism. (11784371)
2002
35
The magnitude of the immune response to heat shock protein-65 following BCG immunisation is associated with the extent of experimental atherosclerosis. (12417273)
2002
36
A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. (11257277)
2001
37
The role of fibric acids in atherosclerosis. (11123853)
2001
38
Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis. (11705704)
2001
39
High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis. (11209972)
2000
40
Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. (10488958)
1999
41
Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. (9614622)
1998
42
Heat-shock protein 65 and atherosclerosis in patients on regular hemodialysis. (9678443)
1998
43
Proposed synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis. (9642484)
1998
44
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. (9312550)
1997
45
Hypertension and atherosclerosis. (8872835)
1996
46
Plasma apolipoproteins B and AI in healthy individuals and patients with coronary atherosclerosis in a male population from Lithuania]. (1753578)
1991
47
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
48
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
49
Cerebral atherosclerosis; a correlative study between physical and psychological pictures. (5478383)
1970
50
Effect of choline in the prevention of experimental aortic atherosclerosis. (18878120)
1948

Variations for Atherosclerosis

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Expression for genes affiliated with Atherosclerosis

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Search GEO for disease gene expression data for Atherosclerosis.

Pathways for genes affiliated with Atherosclerosis

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Pathways related to Atherosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
MAPK Cascade38
Immune response Oncostatin M signaling via MAPK in human cells60
Oncostatin M Signaling Pathway38
10.1CCL2, MMP3, PPARG
210.1CCL2, MMP3, SELE
3
Show member pathways
thioredoxin pathway38
10.1SAA1, CCL2, ALOX5
4
Show member pathways
aspirin triggered resolvin E biosynthesis38
10.1ALOX15, ALOX5, ALOX12
5
Show member pathways
10.1ALOX15, ALOX5, ALOX12
6
Show member pathways
10.0ABCG8, SOAT1, HMGCR
710.0MMP3, CCL2, CTSL
8
Show member pathways
9.4PPARG, ABCG8, PON3, LPA, ALOX12, ALOX5

Compounds for genes affiliated with Atherosclerosis

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Compounds related to Atherosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1bay-x 10056110.5ALOX15, ALOX5, ALOX12
2fenofibric acid45 3011.5HMGCR, PPARG, CCL2
3bw-b 70c6110.5ALOX15, ALOX12, ALOX5
413-hpode4510.5ALOX15, ALOX5, ALOX12
515-hydroxyeicosatetraenoic acid4510.4ALOX15, ALOX5, ALOX12
6sitosterol4510.4SOAT1, HMGCR, ABCG8
7adma4510.4OLR1, CCL2, SELE
8mk 88661 4511.4ALOX5, ALOX12, PPARG, ALOX15
9quinacrine45 1311.3SELE, MMP3, ALOX12, ALOX5
10probucol45 1311.3CCL2, SOAT1, SELE, HMGCR
11ndga4510.3MMP3, PPARG, ALOX12, ALOX5
12sulfasalazine30 45 51 1313.3MMP3, CCL2, SELE, ALOX5, PPARG
13celecoxib45 61 30 51 26 1315.3ALOX5, MMP3, PPARG, HMGCR
14zileuton45 61 30 1313.3ALOX12, ALOX5, ALOX15
15ibuprofen45 30 51 26 1314.3ALOX12, MMP3, PPARG, ALOX5
16bezafibrate45 30 1312.3HMGCR, LPA, SOAT1, PPARG
17baicalein45 6111.3ALOX12, ALOX15, ALOX5
18troglitazone45 30 61 1313.3MMP3, SELE, CCL2, HMGCR, PPARG
19losartan45 51 30 1313.3PPARG, SELE, CCL2, OLR1
20linoleic acid30 45 2612.2OLR1, ALOX15, ALOX5, PPARG, ALOX12
21piroxicam45 1311.2ALOX12, SAA1, MMP3
22fenofibrate45 51 1312.2PPARG, HMGCR, SELE, LPA, CCL2, OLR1
23rofecoxib45 51 30 1313.2ALOX5, MMP3, PPARG
24aspirin45 51 30 2613.2HMGCR, LPA, SELE, PPARG, ALOX5, ALOX12
25prostacyclin4510.2PPARG, SELE, CCL2, ALOX12, ALOX5, HMGCR
26histamine45 30 2612.1HMGCR, OLR1, ALOX5, SELE, CCL2, MMP3
27pravastatin45 51 30 26 1314.1PPARG, HMGCR, OLR1, CCL2, LPA, SELE
28genistein45 30 61 3 26 1315.1ALOX12, MMP3, CCL2, ALOX5, PPARG, SELE
29gamma-linolenic acid45 2611.0ALOX5, PPARG, ALOX15
30n acetylcysteine4510.0CCL2, ALOX5, PPARG, SELE, MMP3, SOAT1
31sb 20358045 6111.0SELE, CCL2, MMP3, ALOX5, PPARG
32indomethacin45 30 61 1313.0OLR1, MMP3, PPARG, ALOX12, ALOX5
33pge24510.0ALOX15, PPARG, MMP3, SELE, CCL2, ALOX12
34creatinine459.9LPA, MMP3, SELE, CCL2, HMGCR, CTSL
35simvastatin45 51 61 30 26 1314.9SAA1, PPARG, SELE, MMP3, LPA, HMGCR
36heparin45 30 26 1312.9CTSL, LPA, SELE, HMGCR, MMP3, ALOX5
37atorvastatin45 51 30 26 1313.9SELE, HMGCR, OLR1, CCL2, LPA, SOAT1
38phosphatidylcholine459.8SELE, PPARG, SOAT1, CCL2, LPA, ALOX12
39cycloheximide459.8HMGCR, ALOX5, ALOX12, PPARG, SELE, SOAT1
40nitric oxide45 26 1311.8SELE, LPA, CCL2, ALOX12, ALOX15, OLR1
41arginine459.8SAA1, LPA, CCL2, ALOX5, HMGCR, OLR1
425 aminosalicylic acid459.8PPARG, CCL2, ALOX5
43fibrinogen459.8SELE, SAA1, LPA, CCL2, SOAT1
44estrogen459.7PPARG, CTSL, ALOX5, ALOX12, LPA, SAA1
45dexamethasone45 51 30 1312.6MMP3, ALOX12, SOAT1, PPARG, HMGCR, CTSL
46vegf459.5PPARG, SOAT1, SELE, LPA, CCL2, ALOX12
47oxygen45 2610.5MMP3, SOAT1, ALOX12, ALOX5, ALOX15, OLR1
48glucose459.5SAA1, PPARG, LPA, ABCG8, CTSL, OLR1
49cholesterol45 30 26 1312.3ATHS, OLR1, CCL2, SAA1, PPARG, MMP3
50lipid459.1ABCG8, PPARG, ATHS, OLR1, SELE, SOAT1

GO Terms for genes affiliated with Atherosclerosis

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Cellular components related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.6SAA1, LPA, CCL2, OLR1, CTSL, MMP3
2extracellular spaceGO:00056159.4CTSL, ALOX5, CCL2, MMP3, PON3, SELE

Biological processes related to Atherosclerosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoxin A4 biosynthetic processGO:0200130310.5ALOX15, ALOX12
2lipoxin metabolic processGO:0200130010.5ALOX5, ALOX12
3hepoxilin biosynthetic processGO:005112210.4ALOX12, ALOX15
4lymphocyte chemotaxisGO:004824710.4CCL2, SAA1
5fatty acid oxidationGO:001939510.4ALOX12, PPARG
6lipoxygenase pathwayGO:001937210.4ALOX15, ALOX5, ALOX12
7arachidonic acid metabolic processGO:001936910.3ALOX15, ALOX5, ALOX12
8response to nutrientGO:000758410.3PPARG, ABCG8, HMGCR
9macrophage chemotaxisGO:004824610.3CCL2, SAA1
10leukocyte cell-cell adhesionGO:000715910.2OLR1, SELE
11leukotriene metabolic processGO:000669110.2ALOX5, ALOX15
12agingGO:000756810.2CCL2, ALOX12, HMGCR
13inflammatory responseGO:000695410.1SELE, CCL2, ALOX15, OLR1
14cholesterol effluxGO:00333449.8SOAT1, ABCG8
15small molecule metabolic processGO:00442819.6ABCG8, LPA, ALOX12, ALOX5, ALOX15, HMGCR

Molecular functions related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:000196810.2CTSL, LPA
2arachidonate 12-lipoxygenase activityGO:000405210.1ALOX15, ALOX12
3iron ion bindingGO:00055069.8ALOX15, ALOX5, ALOX12

Products for genes affiliated with Atherosclerosis

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Sources for Atherosclerosis

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet