MCID: ATH003
MIFTS: 68

Atherosclerosis malady

Cardiovascular diseases category

Summaries for Atherosclerosis

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Sources:
35MedlinePlus, 66Wikipedia, 34MalaCards
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MedlinePlus:35 Atherosclerosis is a disease in which plaque builds up inside your arteries. plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. over time, plaque hardens and narrows your arteries. that limits the flow of oxygen-rich blood to your body. atherosclerosis can lead to serious problems, including coronary artery disease. these arteries supply blood to your heart. when they are blocked, you can suffer angina or a heart attack. carotid artery disease. these arteries supply blood to your brain. when they are blocked you can suffer a stroke. peripheral arterial disease. these arteries are in your arms, legs and pelvis. when they are blocked, you can suffer from numbness, pain and sometimes infections. atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. many people don't know they have it until they have a medical emergency. a physical exam, imaging, and other diagnostic tests can tell if you have it. medicines can slow the progress of plaque buildup. your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. lifestyle changes can also help. these include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. nih: national heart, lung, and blood institute

MalaCards: Atherosclerosis, also known as atherosclerosis, susceptibility to, is related to insulin resistance and hypertension. An important gene associated with Atherosclerosis is ALOX5 (arachidonate 5-lipoxygenase), and among its related pathways are Development VEGF signaling and activation and G protein signaling Ras family GTPases in kinase cascades scheme . The compounds bay-x 1005 and bw-b 70c have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and monocytes, and related mouse phenotypes are tumorigenesis and hematopoietic system.

Wikipedia:66 Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of... more...

Aliases & Classifications for Atherosclerosis

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Sources:
9Disease Ontology, 10diseasecard, 48OMIM, 11DISEASES, 46Novoseek, 35MedlinePlus, 63UMLS, 59SNOMED-CT, 36MeSH, 28ICD9CM, 41NCIt, 26ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


Aliases & Descriptions:

atherosclerosis 9 48 11 46 35 63
atherosclerosis, susceptibility to 10


External Ids:

Disease Ontology9 DOID:1936
MeSH36 D050197
ICD9CM28 440
NCIt41 C35768
ICD1026 I70

Related Diseases for Atherosclerosis

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Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Atherosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 349)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.5SOAT1, HMGCR, CCL2, PPARG, LPA, SAA1
2hypertension31.4CCL2, PPARG, LPA, OLR1, SELE
3hypercholesterolemia31.3LPA, HMGCR, ABCG8, SOAT1, SELE, OLR1
4obesity31.2PPARG, CCL2, MMP3, SELE, LPA, SOAT1
5coronary artery disease31.2OLR1, HMGCR, LPA
6diabetes mellitus31.2LPA, ALOX12, MMP3, SELE, PPARG, CCL2
7familial hypercholesterolemia31.1LPA, SOAT1, HMGCR
8arthritis31.1MMP3, SELE, CCL2, ALOX12, ALOX15, HMGCR
9myocardial infarction31.1ESR1, OLR1
10systemic lupus erythematosus31.0ALOX5, SELE, CCL2, MMP3
11rheumatoid arthritis31.0LPA, SELE, SAA1, CCL2, ALOX12, HMGCR
12type 2 diabetes mellitus30.9LPA, SELE, PPARG, HMGCR, ALOX12, CCL2
13hyperhomocysteinemia30.9LPA, SELE, CCL2
14arteriosclerosis30.8PPARG, CCL2, HMGCR
15vascular disease30.7ESR1, MMP3
16alzheimer's disease30.7PPARG, SOAT1, ALOX5, OLR1, HMGCR, LPA
17hyperglycemia30.6LPA, PPARG, ALOX12, HMGCR, SELE
18coronary stenosis30.6LPA, OLR1
19ischemia30.6OLR1, ALOX5, MMP3, HMGCR, SOAT1, SELE
20peripheral vascular disease30.6SELE, CCL2
21hypertriglyceridemia30.6PPARG, HMGCR, LPA, SELE, ATHS
22acute myocardial infarction30.5LPA, SAA1, SELE, OLR1, HMGCR
23psoriatic arthritis30.4MMP3, SELE
24hyperlipidemia type 330.4LPA, HMGCR
25tangier disease30.3PPARG, LPA
26osteoporosis30.3MMP3, ESR1, ALOX5, ALOX15, HMGCR
27kawasaki disease30.2CCL2, MMP3, SELE
28sitosterolemia30.2ABCG8, HMGCR
29diabetic nephropathy30.2PPARG, CCL2, HMGCR, LPA
30psoriasis30.2ALOX12, SELE, CCL2, ALOX5
31asthma30.2CCL2, ALOX12, ALOX5, SELE, ALOX15, MMP3
32proteinuria30.1ALOX5, CCL2, LPA, OLR1, HMGCR
33colon cancer30.1MMP3, PPARG, SELE, HMGCR, ALOX5
34cerebrovascular disease30.1ALOX5, HMGCR, PON3, OLR1, LPA, ALOX12
35abdominal aortic aneurysm30.0CCL2, MMP3
36endometriosis30.0HMGCR, CCL2, MMP3, ESR1
37prostate cancer30.0SOAT1, ALOX15, ESR1, ALOX5, PPARG, ALOX12
38osteoarthritis29.9OLR1, CCL2, ALOX5, MMP3, SAA1
39congenital heart disease29.9LPA, HMGCR, MMP3
40glomerulonephritis29.9LPA, ALOX5, CCL2
41liver cirrhosis29.8LPA, MMP3, ALOX5
42aortic atherosclerosis11.0
43endotheliitis10.9
44cerebritis10.9
45cerebral atherosclerosis10.9
46artery disease10.7
47lupus erythematosus10.6
48hepatitis10.5
49generalized atherosclerosis10.5
50periodontitis10.5

Graphical network of the top 20 diseases related to Atherosclerosis:



Diseases related to atherosclerosis

Symptoms for Atherosclerosis

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Drugs & Therapeutics for Atherosclerosis

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Atherosclerosis

Drug clinical trials:

Search ClinicalTrials for Atherosclerosis

Search NIH Clinical Center for Atherosclerosis

Search CenterWatch for Atherosclerosis

Genetic Tests for Atherosclerosis

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Anatomical Context for Atherosclerosis

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Atherosclerosis:

34
Heart, Endothelial, Monocytes, Smooth muscle, Kidney, Testes, Brain, Liver, Lung, T cells, Bone, Myeloid, Ovary, Adipocyte, B cells, Pancreas, Prostate, Skin, Thyroid, Colon, Spinal cord, Placenta, Pituitary, Lymph node, Eye, Retina, Skeletal muscle, Globus pallidus

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 EndotheliumArteriesArterial Endothelial Cells Potential therapeutic candidate, affected by disease
2 HeartCoronary Capillary Plexus  Affected by disease
3 HeartCoronary Vessels  Affected by disease

Animal Models for Atherosclerosis or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Atherosclerosis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000200610.2ALOX15, CCL2, ESR1, SOAT1, PPARG
2MP:000539710.0SOAT1, SELE, ABCG8, PPARG, ESR1, MMP3
3MP:000538510.0PPARG, SELE, SOAT1, ESR1, CCL2, ALOX5
4MP:000538710.0ESR1, SOAT1, SELE, PPARG, MMP3, CCL2
5MP:00107719.9PPARG, SELE, SOAT1, ESR1, CCL2, ALOX12
6MP:00053769.9OLR1, PPARG, ABCG8, SELE, SOAT1, PON3
7MP:00053709.8PPARG, ABCG8, SELE, SOAT1, ESR1, CCL2

Publications for Atherosclerosis

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Sources:
53PubMed
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Articles related to Atherosclerosis:

(show top 50)    (show all 4295)
idTitleAuthorsYear
1
Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. (24401215)
2014
2
Acromegaly and oxidative stress: impact on endothelial dysfunction and atherosclerosis. (23608960)
2013
3
Carotid Artery Intima Media Thickness and HsCRP; Predictors for Atherosclerosis in Prediabetic Patients? (24353563)
2013
4
Task force on: 'Early markers of atherosclerosis: influence of age and sex'. (24335886)
2013
5
Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. (24324141)
2013
6
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. (21497768)
2011
7
Atherosclerosis and acetylsalicylic acid are independent risk factors for hemorrhage in patients with gastric or duodenal ulcer. (21220246)
2011
8
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
9
A genome-wide association study of carotid atherosclerosis in HIV-infected men. (20009918)
2010
10
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
11
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (19878569)
2009
12
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis. (19126404)
2009
13
Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. (19205907)
2009
14
Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. (18243217)
2008
15
C-reactive protein and homocysteine as risk factors of atherosclerosis]. (18853656)
2008
16
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
17
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
18
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. (19330073)
2008
19
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults. (17205961)
2007
20
Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. (17591977)
2007
21
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. (17495603)
2007
22
Insulin resistance and atherosclerosis. (16823479)
2006
23
Cyclooxygenase-2 and atherosclerosis: disputation and prospect]. (16626567)
2006
24
Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. (16741184)
2006
25
Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant. (16794232)
2006
26
Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. (15802632)
2005
27
Pregnancy associated plasma protein-A and coronary atherosclerosis: marker, friend, or foe? (16141260)
2005
28
Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice. (14739122)
2004
29
Effects of ethanol on lipids and atherosclerosis. (15006415)
2004
30
Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. (15215180)
2004
31
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. (15178561)
2004
32
Antibodies to oxidized LDL in atherosclerosis development--clinical and animal studies. (15369729)
2004
33
Dissection and atherosclerosis of carotid arteries in the young: role of the apolipoprotein E polymorphism. (11784371)
2002
34
The magnitude of the immune response to heat shock protein-65 following BCG immunisation is associated with the extent of experimental atherosclerosis. (12417273)
2002
35
A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. (11257277)
2001
36
The role of fibric acids in atherosclerosis. (11123853)
2001
37
Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis. (11705704)
2001
38
High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis. (11209972)
2000
39
Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. (10488958)
1999
40
Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. (9614622)
1998
41
Heat-shock protein 65 and atherosclerosis in patients on regular hemodialysis. (9678443)
1998
42
Proposed synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis. (9642484)
1998
43
Components of the insulin resistance syndrome are associated with progression of atherosclerosis in non-grafted arteries 5 years after coronary artery bypass surgery. (9717003)
1998
44
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. (9312550)
1997
45
Hypertension and atherosclerosis. (8872835)
1996
46
Plasma apolipoproteins B and AI in healthy individuals and patients with coronary atherosclerosis in a male population from Lithuania]. (1753578)
1991
47
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
48
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
49
Cerebral atherosclerosis; a correlative study between physical and psychological pictures. (5478383)
1970
50
Effect of choline in the prevention of experimental aortic atherosclerosis. (18878120)
1948

Variations for Atherosclerosis

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Expression for genes affiliated with Atherosclerosis

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atherosclerosis

Search GEO for disease gene expression data for Atherosclerosis.

Pathways for genes affiliated with Atherosclerosis

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Sources:
51PathCards, 61Thomson Reuters, 39NCBI BioSystems Database, 56Reactome, 31KEGG, 52PharmGKB
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Pathways related to Atherosclerosis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
Development VEGF signaling via VEGFR2 generic cascades61
10.3SELE, ESR1, CCL2
2
Show member pathways
MAPK Cascade39
Immune response Oncostatin M signaling via MAPK in human cells61
Oncostatin M Signaling Pathway39
10.3CCL2, MMP3, PPARG
310.3CCL2, MMP3, SELE
4
Show member pathways
thioredoxin pathway39
10.3ALOX5, CCL2, SAA1
5
Show member pathways
10.3ALOX12, ALOX5, ALOX15
6
Show member pathways
aspirin triggered resolvin E biosynthesis39
10.3ALOX15, ALOX5, ALOX12
7
Show member pathways
10.3ABCG8, SOAT1, HMGCR
8
Show member pathways
10.0PPARG, ABCG8, PON3, LPA, ALOX12, ALOX5

Compounds for genes affiliated with Atherosclerosis

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Sources:
62Tocris Bioscience, 46Novoseek, 30IUPHAR, 52PharmGKB, 12DrugBank, 25HMDB, 3BitterDB
See all sources

Compounds related to Atherosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 139)
idCompoundScoreTop Affiliating Genes
1bay-x 10056210.7ALOX5, ALOX15, ALOX12
2bw-b 70c6210.7ALOX15, ALOX5, ALOX12
313-hpode4610.7ALOX12, ALOX15, ALOX5
4mk 88662 4611.7ALOX12, ALOX5, ALOX15, PPARG
515-hydroxyeicosatetraenoic acid4610.7ALOX5, ALOX15, ALOX12
6sulfasalazine30 46 52 1213.6MMP3, ALOX5, PPARG, SELE, CCL2
7fenofibric acid46 3011.6HMGCR, PPARG, CCL2
8sitosterol4610.6SOAT1, HMGCR, ABCG8
9probucol46 1211.6CCL2, SELE, HMGCR, SOAT1
10quinacrine46 1211.6ALOX12, ALOX5, MMP3, SELE
11ndga4610.6ALOX12, MMP3, ALOX5, PPARG
12fenofibrate46 52 1212.6PPARG, LPA, SELE, CCL2, HMGCR, OLR1
13bezafibrate46 30 1212.6PPARG, HMGCR, SOAT1, LPA
14troglitazone46 30 62 1213.6HMGCR, CCL2, MMP3, SELE, PPARG
15adma4610.6CCL2, OLR1, SELE
16prostacyclin4610.6HMGCR, ALOX5, ALOX12, CCL2, SELE, PPARG
17ibuprofen46 30 52 25 1214.6MMP3, ALOX12, PPARG, ALOX5
18linoleic acid30 46 2512.6ALOX15, PPARG, ALOX12, ALOX5, OLR1
19aspirin46 52 30 2513.6SELE, LPA, PPARG, ALOX5, HMGCR, ALOX12
20celecoxib46 62 30 52 25 1215.6HMGCR, PPARG, ALOX5, MMP3
21pravastatin46 52 30 25 1214.5PPARG, OLR1, CCL2, LPA, MMP3, SELE
22zileuton46 62 30 1213.5ALOX15, ALOX5, ALOX12
23histamine46 30 2512.5MMP3, SELE, CCL2, ALOX5, HMGCR, OLR1
24baicalein46 6211.5ALOX5, ALOX15, ALOX12
25losartan46 52 30 1213.5SELE, PPARG, CCL2, OLR1
26genistein46 30 62 3 25 1215.5ALOX12, CCL2, MMP3, ESR1, PPARG, ALOX5
27n acetylcysteine4610.5CCL2, SELE, PPARG, SOAT1, MMP3, ALOX5
28pge24610.5MMP3, ALOX15, ALOX12, PPARG, ALOX5, SELE
29piroxicam46 1211.5MMP3, SAA1, ALOX12
30simvastatin46 52 62 30 25 1215.5CCL2, HMGCR, PPARG, SELE, OLR1, SAA1
31actinomycin d4610.5LPA, SELE, SOAT1, CCL2, ESR1, HMGCR
32atorvastatin46 52 30 25 1214.5SOAT1, LPA, CCL2, OLR1, HMGCR, SELE
33phosphatidylcholine4610.4ALOX5, CCL2, LPA, SOAT1, ALOX15, SELE
34rofecoxib46 52 30 1213.4MMP3, PPARG, ALOX5
35dexamethasone46 52 30 1213.4ALOX12, SOAT1, CCL2, PPARG, MMP3, ALOX5
36cycloheximide4610.4ALOX12, ALOX5, HMGCR, SOAT1, PPARG, ESR1
37indomethacin46 30 62 1213.4OLR1, MMP3, ALOX5, ALOX12, PPARG
38sb 20358046 6211.4SELE, MMP3, ALOX5, PPARG, CCL2
39arginine4610.4SAA1, LPA, OLR1, HMGCR, SOAT1, ALOX5
40estrogen4610.4ESR1, ALOX12, PPARG, SOAT1, LPA, SAA1
41vegf4610.3HMGCR, ESR1, SOAT1, SELE, LPA, ALOX12
42nitric oxide46 25 1212.3ALOX12, CCL2, LPA, SELE, ALOX15, OLR1
43glucose4610.3OLR1, MMP3, SOAT1, PPARG, ALOX12, ABCG8
44gamma-linolenic acid46 2511.3ALOX5, ALOX15, PPARG
45cholesterol46 30 25 1213.2HMGCR, PPARG, PON3, ABCG8, ATHS, SELE
46vitamin d4610.2MMP3, ALOX5, CCL2, PPARG
47fibrinogen4610.2SOAT1, SAA1, LPA, CCL2, SELE
48lipid4610.1ALOX15, ALOX12, LPA, SAA1, MMP3, SOAT1
49oxygen46 2511.1MMP3, ALOX12, ALOX5, ALOX15, OLR1, CCL2
505 aminosalicylic acid4610.0ALOX5, CCL2, PPARG

GO Terms for genes affiliated with Atherosclerosis

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17Gene Ontology
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Cellular components related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1membraneGO:01602010.1OLR1, ALOX15, ALOX12, ESR1, SOAT1

Biological processes related to Atherosclerosis according to GeneCards/GeneDecks:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoxin A4 biosynthetic processGO:200130310.6ALOX15, ALOX12
2lipoxin metabolic processGO:200130010.6ALOX5, ALOX12
3hepoxilin biosynthetic processGO:05112210.6ALOX12, ALOX15
4lipoxygenase pathwayGO:01937210.6ALOX15, ALOX5, ALOX12
5lymphocyte chemotaxisGO:04824710.6CCL2, SAA1
6arachidonic acid metabolic processGO:01936910.6ALOX15, ALOX5, ALOX12
7response to nutrientGO:00758410.5PPARG, ABCG8, HMGCR
8fatty acid oxidationGO:01939510.5ALOX12, PPARG
9inflammatory responseGO:00695410.4SELE, CCL2, ALOX15, OLR1
10macrophage chemotaxisGO:04824610.4CCL2, SAA1
11agingGO:00756810.4CCL2, ALOX12, HMGCR
12leukotriene metabolic processGO:00669110.4ALOX5, ALOX15
13leukocyte cell-cell adhesionGO:00715910.4OLR1, SELE
14cholesterol effluxGO:03334410.0SOAT1, ABCG8
15small molecule metabolic processGO:04428110.0ABCG8, LPA, ALOX12, ALOX5, ALOX15, HMGCR

Molecular functions related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1iron ion bindingGO:00550610.3ALOX15, ALOX5, ALOX12
2arachidonate 12-lipoxygenase activityGO:00405210.0ALOX15, ALOX12

Products for genes affiliated with Atherosclerosis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atherosclerosis

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet