MCID: ATH003
MIFTS: 69

Atherosclerosis malady

Cardiovascular category

Summaries for Atherosclerosis

Sources:
34MedlinePlus, 64Wikipedia, 33MalaCards
See all sources

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MedlinePlus:34 Atherosclerosis is a disease in which plaque builds up inside your arteries. plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. over time, plaque hardens and narrows your arteries. that limits the flow of oxygen-rich blood to your body. atherosclerosis can lead to serious problems, including coronary artery disease. these arteries supply blood to your heart. when they are blocked, you can suffer angina or a heart attack. carotid artery disease. these arteries supply blood to your brain. when they are blocked you can suffer a stroke. peripheral arterial disease. these arteries are in your arms, legs and pelvis. when they are blocked, you can suffer from numbness, pain and sometimes infections. atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. many people don't know they have it until they have a medical emergency. a physical exam, imaging, and other diagnostic tests can tell if you have it. medicines can slow the progress of plaque buildup. your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. lifestyle changes can also help. these include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. nih: national heart, lung, and blood institute

MalaCards: Atherosclerosis, also known as atherosclerosis, susceptibility to, is related to insulin resistance and hypercholesterolemia. An important gene associated with Atherosclerosis is ALOX5 (arachidonate 5-lipoxygenase), and among its related pathways are Metabolism and Lipoprotein metabolism. The compounds lipid and cholesterol have been mentioned in the context of this disorder. Affiliated tissues include skin, ovary and liver, and related mouse phenotypes are homeostasis/metabolism and immune system.

Wikipedia:64 Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of... more...

Aliases & Classifications for Atherosclerosis

Sources:
8Disease Ontology, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 9diseasecard, 27ICD9CM, 57SNOMED-CT, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular


Aliases & Descriptions:

atherosclerosis 8 47 10 45 34 61
atherosclerosis, susceptibility to 9


External Ids:

Disease Ontology8 DOID:1936
ICD9CM27 440
NCIt40 C35768
MeSH35 D050197
ICD1025 I70

Related Diseases for Atherosclerosis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Atherosclerosis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 348)
idRelated DiseaseScoreTop Affiliating Genes
1insulin resistance31.3HMGCR, CCL2, SAA1, PPARG, LPA, SELE
2hypercholesterolemia31.1APOC2, LPA, CETP, SELE, HMGCR, OLR1
3coronary heart disease31.1LPA, PON3, OLR1, HMGCR, SELE, CETP
4coronary artery disease,31.1PPARG, LPA, ATHS, MMP3, GJA4, OLR1
5familial hypercholesterolemia30.9HMGCR, CETP
6arthritis30.9SELE, SAA1, CCL2, MMP3, HMGCR, ALOX5
7systemic lupus erythematosus30.8SELE, CCL2, ALOX5, MMP3
8vascular disease30.8OLR1, HMGCR, SELE, APOC2, LPA, PPARG
9stroke, ischemic30.8LPA, ALOX5AP, SELE, HMGCR
10hyperhomocysteinemia30.6LPA, SELE, CCL2
11arteriosclerosis30.6CCL2, HMGCR, PPARG
12fatty liver disease30.5HMGCR, PPARG, CETP
13peripheral vascular disease30.4SELE, CCL2
14hypertriglyceridemia30.4ATHS, LPA, PPARG, SELE, CETP, APOC2
15acute myocardial infarction30.4HMGCR, SELE, SAA1, LPA, OLR1
16xanthomatosis30.3MSR1
17hyperlipidemia type 330.2HMGCR, CETP, LPA
18polycystic ovary syndrome30.2PPARG
19alzheimer's disease30.1LPA, APOC2, PPARG, HMGCR, MSR1, OLR1
20osteoporosis30.1MMP3, ESR1, ALOX5, ALOX15, HMGCR
21tangier disease30.1PPARG, LPA, CETP
22glucose intolerance30.1APOC2, CETP, PPARG
23vasculitis30.1SELE, CCL2
24asthma30.0ALOX5, SELE, ALOX15, CCL2, CETP, ALOX5AP
25diabetic nephropathy30.0LPA, PPARG, HMGCR, CCL2
26sitosterolemia30.0HMGCR, ABCG8
27hepatitis c30.0HMGCR
28abdominal aortic aneurysm29.9CCL2, MMP3, CETP
29angioedema29.9ALOX5
30cadasil29.7OLR1, ALOX5, ALOX5AP, PON3, CETP, LPA
31osteoarthritis29.7ALOX5, CCL2, SAA1, MMP3, OLR1, ALOX5AP
32nephritis29.6CCL2
33lupus nephritis29.6CCL2
34primary pulmonary hypertension29.6ALOX5
35cholelithiasis29.6ABCG8
36uterine fibroid29.6ESR1
37aortic atherosclerosis11.0
38cerebral atherosclerosis10.9
39lip disease10.5
40generalized atherosclerosis10.5
41aortic disease10.4
42uremia10.4
43cardiovascular disease risk factor10.4
44n syndrome10.3
45aortic aneurysm10.3
46angina pectoris10.2
47coronary thrombosis10.2
48coronary restenosis10.2
49apo a-i deficiency10.2
50carotid stenosis10.2

Graphical network of the top 20 diseases related to Atherosclerosis:



Diseases related to atherosclerosis

Clinical Features for Atherosclerosis

Drugs & Therapeutics for Atherosclerosis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Atherosclerosis

Drug clinical trials:

Search ClinicalTrials for Atherosclerosis

Search NIH Clinical Center for Atherosclerosis

Search CenterWatch for Atherosclerosis

Genetic Tests for Atherosclerosis

Anatomical Context for Atherosclerosis

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Atherosclerosis:

33
Skin, Ovary, Liver, Spinal cord, Brain, Kidney, Lymph node, Lung, Bone marrow, Whole blood, Retina, Heart, Smooth muscle, Skeletal muscle, Small intestine, Colon, Adipocyte, Pancreas, Thyroid, Placenta, Prostate, Myeloid, Monocytes, Nk cells, T cells, B cells, Endothelial, Globus pallidus, Pituitary

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 EndotheliumArteriesArterial Endothelial Cells Potential therapeutic candidate, affected by disease
2 HeartCoronary Capillary Plexus  Affected by disease
3 HeartCoronary Vessels  Affected by disease

Animal Models for Atherosclerosis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Atherosclerosis

Sources:
51PubMed
See all sources

Articles related to Atherosclerosis:

(show top 50)    (show all 4340)
idTitleAuthorsYear
1
Investigation of necessity of sodium cholate and minimal required amount of cholesterol for dietary induction of atherosclerosis in microminipigs. (24425840)
2014
2
Association of E-Selectin Gene Polymorphism and Serum PAPP-A with Carotid Atherosclerosis in End-Stage Renal Disease. (24151105)
2013
3
Serum levels and polymorphisms of matrix metalloproteinases (MMPs) in carotid artery atherosclerosis: higher MMP-9 levels are associated with plaque vulnerability. (24369095)
2013
4
Nonrelevant cerebral atherosclerosis is a strong prognostic factor in acute cerebral infarction. (23686972)
2013
5
The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10. (23813974)
2013
6
Overexpression of NF-I_B p65 in macrophages ameliorates atherosclerosis in apoE-knockout mice. (24105415)
2013
7
Gender differences in the association between socioeconomic status and subclinical atherosclerosis. (24282522)
2013
8
The Role of Vitamin D in Atherosclerosis Inflammation Revisited: More a Bystander than a Player? (24329737)
2013
9
Association Between Renal Vasculature Changes and Generalized Atherosclerosis: An Autopsy Survey. (24096900)
2013
10
The association of inflammatory and fibrinolytic proteins with 5 year change in insulin clearance: the Insulin Resistance Atherosclerosis Study (IRAS). (23052060)
2013
11
Bone mineral density and atherosclerosis: the Multi-Ethnic Study of Atherosclerosis, Abdominal Aortic Calcium Study. (19819456)
2010
12
Genetic variants identified in a European genome-wide association study that were found to predict incident coronary heart disease in the atherosclerosis risk in communities study. (19955471)
2010
13
Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. (19131645)
2009
14
Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice. (19858416)
2009
15
Transgenic expression of matrix metalloproteinase-9 modulates collagen deposition in a mouse model of atherosclerosis. (19144335)
2009
16
Lipoprotein-associated phospholipase A(2) and atherosclerosis. (19667981)
2009
17
Enhanced CD36 scavenger receptor expression in THP-1 human monocytes in the presence of lupus plasma: linking autoimmunity and atherosclerosis. (19144874)
2009
18
Fatty acid binding proteins in adipose tissue: a promising link between metabolic syndrome and atherosclerosis? (18977052)
2008
19
Lipoprotein(a) and its position among other risk factors of atherosclerosis. (18198982)
2008
20
Macrophages: an elusive yet emerging therapeutic target of atherosclerosis. (18000963)
2008
21
Experimentally induced metabolic acidosis in rabbits modulates the interaction of aortic glycosaminoglycan with plasma low-density lipoprotein--an interesting observation about the association of acidosis and atherosclerosis. (17056046)
2007
22
Accelerated atherosclerosis in rheumatoid arthritis. (17893998)
2007
23
Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study. (17562993)
2007
24
Statin therapy alone and in combination with an acyl-CoA:cholesterol O-acyltransferase inhibitor on experimental atherosclerosis. (18332609)
2007
25
Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis. (17721609)
2007
26
Osteopontin and carotid atherosclerosis in patients with essential hypertension. (16776647)
2006
27
Inferior myocardial infarction and extensive atherosclerosis in a patient with double right coronary artery. (16413074)
2006
28
Metabolic syndrome, inflammation and atherosclerosis. (17319458)
2006
29
Levels of antibodies to microorganisms implicated in atherosclerosis and of C-reactive protein among atomic bomb survivors. (16881737)
2006
30
Familial hypercholesterolemia patients treated with statins at no increased risk for intracranial vascular lesions despite increased cholesterol burden and extracranial atherosclerosis. (15933262)
2005
31
Inherited disorders of HDL metabolism and atherosclerosis. (15767853)
2005
32
Role of the hemostatic system in pathogenesis of atherosclerosis as the main etiology of coronary ischemia] [corrected]. (15518428)
2004
33
Involvement of leukotactin-1, a novel CC chemokine, in human atherosclerosis. (15135248)
2004
34
Dual benefit of reduced Cx43 on atherosclerosis in LDL receptor-deficient mice. (14681047)
2003
35
Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis study. (12702517)
2003
36
Role of adiponectin in insulin-resistant hypertension and atherosclerosis. (14620925)
2003
37
Inhibition of ileal bile acid transport and reduced atherosclerosis in apoE-/- mice by SC-435. (12810816)
2003
38
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. (12639996)
2003
39
C-reactive protein is more strongly related to post-glucose load glucose than to fasting glucose in non-diabetic subjects; the Insulin Resistance Atherosclerosis Study. (12421431)
2002
40
Plasma levels of cystatin-C and mannose binding protein are not associated with risk of developing systemic atherosclerosis. (11789968)
2001
41
Mast cells and atherosclerosis]. (11987828)
2001
42
Proliferative activity and chromosomal alterations of smooth muscle cells in atherosclerosis]. (11188899)
2000
43
New model of atherosclerosis in insulin resistant sand rats: hypercholesterolemia combined with D2 vitamin. (10781635)
2000
44
Plasma and vessel wall lipoprotein lipase have different roles in atherosclerosis. (10744772)
2000
45
Dietary cholesterol-induced xanthomatosis in atherosclerosis-susceptible Japanese quail (Cotunix japonica). (9839203)
1998
46
Baseline characteristics of subjects in the Lipoprotein and Coronary Atherosclerosis Study (LCAS) with fluvastatin. (8198024)
1994
47
Ankle-arm index as a marker of atherosclerosis in the Cardiovascular Health Study. Cardiovascular Heart Study (CHS) Collaborative Research Group. (8353913)
1993
48
Variations in the size of the human brain. Influence of age, sex, body length, body mass index, alcoholism, Alzheimer changes, and cerebral atherosclerosis. (3887832)
1985
49
Fibrinogen and low density lipoprotein in the development of cerebral atherosclerosis. (229873)
1979
50
Comparative studies of cerebral atherosclerosis. (4107595)
1971

Genetic Variations for Atherosclerosis

Expression for genes affiliated with Atherosclerosis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Atherosclerosis

Search GEO for disease gene expression data for Atherosclerosis.

Pathways for genes affiliated with Atherosclerosis

Sources:
54Reactome, 30KEGG, 50PharmGKB, 38NCBI BioSystems Database, 12EMD Millipore, 52QIAGEN
See all sources

Pathways related to Atherosclerosis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.8ABCG8, HMGCR, CETP, CEL, ALOX5AP, ALOX5
2
Hide members
11.4CEL, CETP, ABCG8, LPA, APOC2
3
Hide members
11.2APOC2, ABCG8, HMGCR, CETP
411.2CCL2, SAA1, ALOX5AP, ALOX5
5
G-protein signaling Ras family GTPases in kinase cascades (scheme)
Hide members
11.1CCL2, PPARG, MMP3
611.1SELE, MMP3, CCL2
7
Hide members
11.1ALOX5AP, ALOX5, ALOX15
8
Hide members
11.1ALOX5AP, ALOX5, ALOX15
911.1ALOX15, ALOX5, ALOX5AP
1010.9CETP, LPA
11
Hide members
10.9ALOX5, ALOX15
12
Hide members
10.9ALOX5, ALOX5AP
1310.9MSR1, CCL2

Compounds for genes affiliated with Atherosclerosis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Atherosclerosis according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1lipid4514.0ABCG8, HMGCR, MSR1, CETP, CEL, ALOX5AP
2cholesterol45 29 11 2416.8CCL2, MSR1, SELE, CETP, CEL, HMGCR
3simvastatin45 50 60 29 11 2417.9CEL, CETP, SELE, HMGCR, MMP3, LPA
4pravastatin45 50 29 11 2416.5LPA, SELE, CETP, HMGCR, OLR1, MMP3
5phosphatidylcholine4512.5CCL2, LPA, PPARG, ALOX15, SELE, CEL
6heparin45 29 11 2415.4MMP3, SELE, CEL, LPA, HMGCR, ALOX5
7vegf4512.4CCL2, ALOX5, MMP3, LPA, SELE, HMGCR
8nitric oxide45 11 2414.4SELE, MSR1, OLR1, ALOX5AP, ALOX15, LPA
9serine4512.3GJA4, ALOX5, CCL2, CEL, APOC2, MMP3
10fenofibrate45 50 1114.3OLR1, LPA, HMGCR, PPARG, CCL2, CETP
11linoleic acid45 29 2414.3ALOX5, CEL, CETP, OLR1, PPARG, ALOX15
12atorvastatin45 50 29 11 2416.3LPA, SELE, CCL2, PPARG, OLR1, CETP
13aspirin45 50 29 2415.3ALOX5AP, CETP, SELE, HMGCR, LPA, PPARG
14n acetylcysteine4512.2MSR1, HMGCR, MMP3, CCL2, PPARG, SELE
15histamine45 29 2414.2ALOX5AP, SELE, HMGCR, OLR1, MMP3, CCL2
16glucose4512.0MSR1, OLR1, LPA, PPARG, SAA1, APOC2
17phospholipid4512.0OLR1, ABCG8, CETP, ALOX15, APOC2, CEL
18actinomycin d4512.0ALOX5AP, SELE, HMGCR, LPA, CCL2, ESR1
19genistein45 29 60 2 11 2416.9MMP3, SELE, CCL2, ALOX5, ESR1, PPARG
20gemfibrozil45 29 1113.9CETP, HMGCR, LPA, PPARG, APOC2
21cholesterol ester4511.9HMGCR, LPA, MSR1, CETP, CEL
22sulfasalazine45 29 50 1114.9ALOX5, CCL2, MMP3, SELE, PPARG
23arginine4511.8LPA, ALOX5, OLR1, CCL2, CETP, SAA1
24homocysteine45 2412.8SELE, CETP, APOC2, CCL2, LPA
25troglitazone45 29 60 1114.8CCL2, HMGCR, PPARG, SELE, MMP3
26prostacyclin4511.8ALOX5, SELE, PPARG, CCL2, HMGCR
27mk 88660 4512.7ALOX5AP, ALOX5, PPARG, ALOX15
28probucol45 1112.7CETP, CCL2, HMGCR, SELE
29fatty acid4511.6LPA, PPARG, CETP, CEL, APOC2
30niacin45 1112.6LPA, CETP, PPARG, HMGCR
31bezafibrate45 29 1113.6HMGCR, CETP, LPA, PPARG
32ndga4511.6MMP3, PPARG, ALOX5, ALOX5AP
33fluvastatin45 50 29 1114.5SELE, CETP, CCL2, HMGCR
34bw-b 70c6011.5ALOX15, ALOX5, ALOX5AP
35bay-x 10056011.4ALOX5, ALOX15, ALOX5AP
36celecoxib45 60 29 50 11 2416.4MMP3, HMGCR, PPARG, ALOX5
37creatinine4511.4HMGCR, MMP3, LPA, APOC2, SELE
38alpha tocopherol4511.4MSR1, CEL, ALOX5
39fenofibric acid45 2912.4HMGCR, PPARG, CCL2
40losartan45 50 29 1114.4CCL2, PPARG, OLR1, SELE
41cholestyramine4511.4HMGCR, LPA, CETP
42lathosterol45 2412.3HMGCR, ABCG8, CETP
43adma4511.3OLR1, SELE, CCL2
44zileuton60 45 29 1114.3ALOX15, ALOX5AP, ALOX5
45dexamethasone45 50 29 1114.3ALOX5AP, ALOX5, SAA1
46baicalein60 4512.2ALOX5AP, ALOX5, ALOX15
47cycloheximide4511.1ALOX5AP
48pge24511.1ALOX5AP
49rofecoxib45 50 29 1114.0PPARG, MMP3, ALOX5
50gamma-linolenic acid45 2411.8ALOX5, ALOX15, PPARG

GO Terms for genes affiliated with Atherosclerosis

Sources:
16Gene Ontology
See all sources

Cellular components related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557612.1CEL, CCL2, SAA1, APOC2, LPA, PON3
2extracellular spaceGO:00561511.5CCL2, APOC2, PON3, MMP3, SELE, CETP
3low-density lipoprotein particleGO:03436210.9MSR1, APOC2

Biological processes related to Atherosclerosis according to GeneCards/GeneDecks:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1small molecule metabolic processGO:04428112.5APOC2, LPA, ABCG8, HMGCR, CETP, CEL
2lipoprotein metabolic processGO:04215711.6CETP, OLR1, LPA, APOC2
3lipoxygenase pathwayGO:01937211.4ALOX5AP, ALOX5, ALOX15
4lipoprotein transportGO:04295311.4MSR1, PPARG, APOC2
5leukotriene metabolic processGO:00669111.4ALOX5AP, ALOX5, ALOX15
6receptor-mediated endocytosisGO:00689811.3LPA, MSR1, CETP
7arachidonic acid metabolic processGO:01936911.3ALOX15, ALOX5, ALOX5AP
8response to drugGO:04249311.3CCL2, APOC2, PPARG, ABCG8
9cholesterol homeostasisGO:04263211.3APOC2, ABCG8, CETP
10response to nutrientGO:00758411.2PPARG, ABCG8, HMGCR
11leukotriene production involved in inflammatory responseGO:00254011.2ALOX5, ALOX5AP
12lipoxin metabolic processGO:200130011.1ALOX5, ALOX5AP
13very-low-density lipoprotein particle remodelingGO:03437211.1CETP, APOC2
14lymphocyte chemotaxisGO:04824711.1SAA1, CCL2
15phospholipid transportGO:01591411.0CETP, ABCG8
16intestinal cholesterol absorptionGO:03029911.0CEL, ABCG8
17inflammatory responseGO:00695410.9CCL2, OLR1, SELE, ALOX15
18negative regulation of macrophage derived foam cell differentiationGO:01074510.9CETP, PPARG
19cholesterol transportGO:03030110.9CETP, MSR1
20macrophage chemotaxisGO:04824610.8SAA1, CCL2

Molecular functions related to Atherosclerosis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cholesterol transporter activityGO:01712710.9CETP, ABCG8
2arachidonic acid bindingGO:05054410.8ALOX5AP, PPARG
3phospholipase bindingGO:04327410.6SELE, APOC2

Products for genes affiliated with Atherosclerosis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atherosclerosis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet