MCID: ATH003
MIFTS: 56

Atherosclerosis malady

Cardiovascular diseases category

Summaries for Atherosclerosis

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MedlinePlus:32 Atherosclerosis is a disease in which plaque builds up inside your arteries. plaque is a sticky substance made up of fat, cholesterol, calcium, and other substances found in the blood. over time, plaque hardens and narrows your arteries. that limits the flow of oxygen-rich blood to your body. atherosclerosis can lead to serious problems, including coronary artery disease. these arteries supply blood to your heart. when they are blocked, you can suffer angina or a heart attack. carotid artery disease. these arteries supply blood to your brain. when they are blocked you can suffer a stroke. peripheral arterial disease. these arteries are in your arms, legs and pelvis. when they are blocked, you can suffer from numbness, pain and sometimes infections. atherosclerosis usually doesn't cause symptoms until it severely narrows or totally blocks an artery. many people don't know they have it until they have a medical emergency. a physical exam, imaging, and other diagnostic tests can tell if you have it. medicines can slow the progress of plaque buildup. your doctor may also recommend procedures such as angioplasty to open the arteries, or surgery on the coronary or carotid arteries. lifestyle changes can also help. these include following a healthy diet, getting regular exercise, maintaining a healthy weight, quitting smoking, and managing stress. nih: national heart, lung, and blood institute

MalaCards based summary: Atherosclerosis, also known as atherosclerosis, susceptibility to, is related to coronary artery disease and obesity. An important gene associated with Atherosclerosis is PPARG (peroxisome proliferator-activated receptor gamma), and among its related pathways are G protein signaling Ras family GTPases in kinase cascades scheme and TNF signaling pathway. The compounds bay-x 1005 and fenofibric acid have been mentioned in the context of this disorder. Affiliated tissues include heart, endothelial and monocytes, and related mouse phenotypes are liver/biliary system and cardiovascular system.

Wikipedia:63 Atherosclerosis (also known as arteriosclerotic vascular disease or ASVD) is a specific form of... more...

Aliases & Classifications for Atherosclerosis

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Atherosclerosis, Aliases & Descriptions:

Name: Atherosclerosis 30 9 11 43 32 60
 
Atherosclerosis, Susceptibility to 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Cardiovascular diseases


External Ids:

Disease Ontology9 DOID:1936
ICD9CM27 440
MeSH33 D050197
NCIt38 C35768
ICD1025 I70

Related Diseases for Atherosclerosis

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Diseases related to Atherosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 342)
idRelated DiseaseScoreTop Affiliating Genes
1coronary artery disease31.7LPA, HMGCR, OLR1
2obesity31.5ALOX5, PPARG, CCL2, LPA, MMP3, SELE
3systemic lupus erythematosus31.5CCL2, MMP3, ALOX5, SELE
4myocardial infarction31.5LPA, HMGCR, GJA4, SAA1, OLR1
5hyperhomocysteinemia31.4SELE, LPA, CCL2
6arteriosclerosis31.4CCL2, PPARG, HMGCR
7aneurysm31.4CTSL, ALOX5, MMP3
8coronary stenosis31.2OLR1, LPA
9peripheral vascular disease31.1SELE, CCL2
10arthritis31.1ALOX5, CTSL, CCL2, ALOX15, MMP3, HMGCR
11hypertriglyceridemia31.1SELE, HMGCR, LPA, ATHS, PPARG
12hyperglycemia31.0ALOX12, LPA, HMGCR, SELE, PPARG
13vascular disease31.0OLR1, HMGCR, CTSL, ALOX12, CCL2, LPA
14hyperlipidemia type 331.0HMGCR, LPA
15acute myocardial infarction31.0HMGCR, LPA, SAA1, SELE, OLR1
16ischemia31.0SELE, HMGCR, OLR1, SOAT1, MMP3, ALOX5
17rheumatoid arthritis30.9LPA, SELE, SAA1, MMP3, CCL2, ALOX12
18sitosterolemia30.9HMGCR, ABCG8
19kawasaki disease30.8CCL2, MMP3, SELE
20tangier disease30.7LPA, PPARG
21osteoporosis30.7MMP3, HMGCR, CTSL, ALOX5, ALOX15
22psoriatic arthritis30.6SELE, MMP3
23abdominal aortic aneurysm30.6CCL2, CTSL, MMP3
24asthma30.6ALOX12, SELE, ALOX15, ALOX5, CCL2, MMP3
25psoriasis30.6ALOX5, CCL2, CTSL, SELE, ALOX12
26hypercholesterolemia, familial30.4LPA, SOAT1, HMGCR
27proteinuria30.4OLR1, CTSL, HMGCR, LPA, CCL2, ALOX5
28glomerulonephritis30.3LPA, CCL2, ALOX5
29congenital heart disease30.3MMP3, HMGCR, LPA
30prostate cancer30.3ALOX12, CTSL, ALOX15, SOAT1, PPARG, ALOX5
31endometriosis30.3MMP3, HMGCR, CCL2
32osteoarthritis30.1MMP3, CTSL, OLR1, ALOX5, CCL2, SAA1
33alzheimer disease30.1CTSL, HMGCR, OLR1, LPA, ALOX5, SOAT1
34aortic atherosclerosis11.0
35endotheliitis10.9
36cerebritis10.9
37cerebral atherosclerosis10.9
38artery disease10.8
39lupus erythematosus10.6
40hepatitis10.5
41generalized atherosclerosis10.5
42periodontitis10.5
43secondary amyloidosis10.5LPA, SAA1
44arthropathy10.5MMP3, HMGCR, ALOX5
45stroke, ischemic10.5SELE, LPA, HMGCR
46monocytic leukemia10.5OLR1, CCL2, PPARG
47pulmonary fibrosis10.5ALOX5, CCL2, PPARG
48acute respiratory distress syndrome10.4SELE, ALOX5
49uremia10.4
50allergic asthma10.4CCL2, ALOX5, SELE

Graphical network of the top 20 diseases related to Atherosclerosis:



Diseases related to atherosclerosis

Symptoms for Atherosclerosis

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Drugs & Therapeutics for Atherosclerosis

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Drug clinical trials:

Search ClinicalTrials for Atherosclerosis

Search NIH Clinical Center for Atherosclerosis

Genetic Tests for Atherosclerosis

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Anatomical Context for Atherosclerosis

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MalaCards organs/tissues related to Atherosclerosis:

31
Heart, Endothelial, Monocytes, Smooth muscle, Kidney, Testes, Brain, T cells, Lung, Liver, Bone, Neutrophil, Adipocyte, Ovary, Myeloid, Thyroid, B cells, Colon, Pancreas, Skin, Prostate, Spinal cord, Bone marrow, Eye, Lymph node, Retina, Skeletal muscle, Placenta, Globus pallidus, Pituitary

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database

Cells/anatomical compartments in embryo or adult related to Atherosclerosis:
id TissueAnatomical CompartmentCell Relevance
1 EndotheliumArteriesArterial Endothelial Cells Potential therapeutic candidate, affected by disease
2 HeartCoronary Capillary Plexus  Affected by disease
3 HeartCoronary Vessels  Affected by disease

Animal Models for Atherosclerosis or affiliated genes

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MGI Mouse Phenotypes related to Atherosclerosis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053709.6ABCG8, SELE, SOAT1, CCL2, CTSL, PPARG
2MP:00053859.3CCL2, PPARG, GJA4, ALOX5, ALOX15, OLR1
3MP:00107719.1CTSL, PPARG, ALOX15, ALOX12, CCL2, SOAT1
4MP:00053979.1CTSL, ALOX15, ABCG8, SELE, SOAT1, MMP3
5MP:00053879.1ALOX5, ALOX15, OLR1, CTSL, MMP3, SOAT1
6MP:00053768.9CCL2, ALOX12, SAA1, MMP3, PON3, SOAT1

Publications for Atherosclerosis

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Articles related to Atherosclerosis:

(show top 50)    (show all 4437)
idTitleAuthorsYear
1
Psychosocial Predictors of Metabolic Syndrome among Latino Groups in the Multi-Ethnic Study of Atherosclerosis (MESA). (25906072)
2015
2
Hematopoietic Akt2 deficiency attenuates the progression of atherosclerosis. (25392271)
2014
3
Curcumin modulation of high fat diet-induced atherosclerosis and steatohepatosis in LDL receptor deficient mice. (24401215)
2014
4
Acromegaly and oxidative stress: impact on endothelial dysfunction and atherosclerosis. (23608960)
2013
5
Carotid Artery Intima Media Thickness and HsCRP; Predictors for Atherosclerosis in Prediabetic Patients? (24353563)
2013
6
Task force on: 'Early markers of atherosclerosis: influence of age and sex'. (24335886)
2013
7
Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. (24324141)
2013
8
Gender differences in risk factors for intracranial cerebral atherosclerosis among asymptomatic subjects. (21497768)
2011
9
Accelerated atherosclerosis in rheumatoid arthritis: rationale for mannose-binding lectins? (20197564)
2010
10
A genome-wide association study of carotid atherosclerosis in HIV-infected men. (20009918)
2010
11
Retinal microvascular signs and 10-year risk of cerebral atrophy: the Atherosclerosis Risk in Communities (ARIC) study. (20576949)
2010
12
Candidate genetic analysis of plasma high-density lipoprotein-cholesterol and severity of coronary atherosclerosis. (19878569)
2009
13
Combined effect of oxidative stress-related gene polymorphisms on atherosclerosis. (19126404)
2009
14
Mechanical properties of the extracellular matrix alter expression of smooth muscle protein LPP and its partner palladin; relationship to early atherosclerosis and vascular injury. (19205907)
2009
15
Cholesteryl ester transfer protein genetic polymorphisms, HDL cholesterol, and subclinical cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. (18243217)
2008
16
C-reactive protein and homocysteine as risk factors of atherosclerosis]. (18853656)
2008
17
Inflammation in atherosclerosis and psoriasis: common pathogenic mechanisms and the potential for an integrated treatment approach. (18700910)
2008
18
Novel metabolic risk factors for incident heart failure and their relationship with obesity: the MESA (Multi-Ethnic Study of Atherosclerosis) study. (18452784)
2008
19
Pravastatin prevents aortic atherosclerosis via modulation of signal transduction and activation of transcription 3 (STAT3) to attenuate interleukin-6 (IL-6) action in ApoE knockout mice. (19330073)
2008
20
Microalbuminuria, but not cystatin C, is associated with carotid atherosclerosis in middle-aged adults. (17205961)
2007
21
Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis. (17591977)
2007
22
Bile acids, farnesoid X receptor, atherosclerosis and metabolic control. (17495603)
2007
23
Insulin resistance and atherosclerosis. (16823479)
2006
24
Cyclooxygenase-2 and atherosclerosis: disputation and prospect]. (16626567)
2006
25
Inflammation and atherosclerosis: novel insights into plaque formation and destabilization. (16741184)
2006
26
Inflammation and atherosclerosis: Group IIa and Group V sPLA2 are not redundant. (16794232)
2006
27
Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. (15802632)
2005
28
Pregnancy associated plasma protein-A and coronary atherosclerosis: marker, friend, or foe? (16141260)
2005
29
Monocyte chemoattractant protein-1 is an essential inflammatory mediator in angiotensin II-induced progression of established atherosclerosis in hypercholesterolemic mice. (14739122)
2004
30
Effects of ethanol on lipids and atherosclerosis. (15006415)
2004
31
Regulation of macrophage foam cell formation by alphaVbeta3 integrin: potential role in human atherosclerosis. (15215180)
2004
32
Endothelial overexpression of Fas ligand decreases atherosclerosis in apolipoprotein E-deficient mice. (15178561)
2004
33
Antibodies to oxidized LDL in atherosclerosis development--clinical and animal studies. (15369729)
2004
34
Dissection and atherosclerosis of carotid arteries in the young: role of the apolipoprotein E polymorphism. (11784371)
2002
35
The magnitude of the immune response to heat shock protein-65 following BCG immunisation is associated with the extent of experimental atherosclerosis. (12417273)
2002
36
A prospective study of coronary heart disease and the hemochromatosis gene (HFE) C282Y mutation: the Atherosclerosis Risk in Communities (ARIC) study. (11257277)
2001
37
The role of fibric acids in atherosclerosis. (11123853)
2001
38
Correlation between intima-to-media ratio, apolipoprotein B-100, myeloperoxidase, and hypochlorite-oxidized proteins in human atherosclerosis. (11705704)
2001
39
High-density lipoprotein: gene-based approaches to the prevention of atherosclerosis. (11209972)
2000
40
Angiotensinogen T174M and M235T gene polymorphisms are associated with the extent of coronary atherosclerosis. (10488958)
1999
41
Carotid atherosclerosis in adolescents and young adults with IDDM. Relation to urinary endothelin, albumin, free cortisol, and other factors. (9614622)
1998
42
Heat-shock protein 65 and atherosclerosis in patients on regular hemodialysis. (9678443)
1998
43
Proposed synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis. (9642484)
1998
44
Apolipoprotein E2 transgenic rabbits. Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. (9312550)
1997
45
Hypertension and atherosclerosis. (8872835)
1996
46
Plasma apolipoproteins B and AI in healthy individuals and patients with coronary atherosclerosis in a male population from Lithuania]. (1753578)
1991
47
Aortic atherosclerosis in nonlaying hens with fatty liver syndrome. (6639549)
1983
48
Metformin action on lipid metabolism in lesions of experimental aortic atherosclerosis of rabbits. (6870991)
1983
49
Cerebral atherosclerosis; a correlative study between physical and psychological pictures. (5478383)
1970
50
Effect of choline in the prevention of experimental aortic atherosclerosis. (18878120)
1948

Variations for Atherosclerosis

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Expression for genes affiliated with Atherosclerosis

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Search GEO for disease gene expression data for Atherosclerosis.

Pathways for genes affiliated with Atherosclerosis

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Pathways related to Atherosclerosis according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
MAPK Cascade36
Immune response Oncostatin M signaling via MAPK in human cells58
Oncostatin M Signaling Pathway36
10.1CCL2, MMP3, PPARG
210.1CCL2, MMP3, SELE
3
Show member pathways
thioredoxin pathway36
10.1SAA1, CCL2, ALOX5
4
Show member pathways
aspirin triggered resolvin E biosynthesis36
10.1ALOX15, ALOX5, ALOX12
5
Show member pathways
10.1ALOX15, ALOX5, ALOX12
6
Show member pathways
10.0ABCG8, SOAT1, HMGCR
710.0MMP3, CCL2, CTSL
8
Show member pathways
9.4PPARG, ABCG8, PON3, LPA, ALOX12, ALOX5

Compounds for genes affiliated with Atherosclerosis

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Compounds related to Atherosclerosis according to GeneCards Suite gene sharing:

(show top 50)    (show all 137)
idCompoundScoreTop Affiliating Genes
1bay-x 10055910.5ALOX15, ALOX5, ALOX12
2fenofibric acid43 2811.5HMGCR, PPARG, CCL2
3bw-b 70c5910.5ALOX15, ALOX12, ALOX5
413-hpode4310.5ALOX15, ALOX5, ALOX12
515-hydroxyeicosatetraenoic acid4310.4ALOX15, ALOX5, ALOX12
6sitosterol4310.4SOAT1, HMGCR, ABCG8
7adma4310.4OLR1, CCL2, SELE
8mk 88659 4311.4ALOX5, ALOX12, PPARG, ALOX15
9quinacrine43 1211.3SELE, MMP3, ALOX12, ALOX5
10probucol43 1211.3CCL2, SOAT1, SELE, HMGCR
11ndga4310.3MMP3, PPARG, ALOX12, ALOX5
12sulfasalazine28 43 49 1213.3MMP3, CCL2, SELE, ALOX5, PPARG
13celecoxib43 59 28 49 24 1215.3ALOX5, MMP3, PPARG, HMGCR
14zileuton43 59 28 1213.3ALOX12, ALOX5, ALOX15
15ibuprofen43 28 49 24 1214.3ALOX12, MMP3, PPARG, ALOX5
16bezafibrate43 28 1212.3HMGCR, LPA, SOAT1, PPARG
17baicalein43 5911.3ALOX12, ALOX15, ALOX5
18troglitazone43 28 59 1213.3MMP3, SELE, CCL2, HMGCR, PPARG
19losartan43 49 28 1213.3PPARG, SELE, CCL2, OLR1
20linoleic acid28 43 2412.2OLR1, ALOX15, ALOX5, PPARG, ALOX12
21piroxicam43 1211.2ALOX12, SAA1, MMP3
22fenofibrate43 49 1212.2PPARG, HMGCR, SELE, LPA, CCL2, OLR1
23rofecoxib43 49 28 1213.2ALOX5, MMP3, PPARG
24aspirin43 49 28 2413.2HMGCR, LPA, SELE, PPARG, ALOX5, ALOX12
25prostacyclin4310.2PPARG, SELE, CCL2, ALOX12, ALOX5, HMGCR
26histamine43 28 2412.1HMGCR, OLR1, ALOX5, SELE, CCL2, MMP3
27pravastatin43 49 28 24 1214.1PPARG, HMGCR, OLR1, CCL2, LPA, SELE
28genistein43 28 59 2 24 1215.1ALOX12, MMP3, CCL2, ALOX5, PPARG, SELE
29gamma-linolenic acid43 2411.0ALOX5, PPARG, ALOX15
30n acetylcysteine4310.0CCL2, ALOX5, PPARG, SELE, MMP3, SOAT1
31sb 20358043 5911.0SELE, CCL2, MMP3, ALOX5, PPARG
32indomethacin43 28 59 1213.0OLR1, MMP3, PPARG, ALOX12, ALOX5
33pge24310.0ALOX15, PPARG, MMP3, SELE, CCL2, ALOX12
34creatinine439.9LPA, MMP3, SELE, CCL2, HMGCR, CTSL
35simvastatin43 49 59 28 24 1214.9SAA1, PPARG, SELE, MMP3, LPA, HMGCR
36heparin43 28 24 1212.9CTSL, LPA, SELE, HMGCR, MMP3, ALOX5
37atorvastatin43 49 28 24 1213.9SELE, HMGCR, OLR1, CCL2, LPA, SOAT1
38phosphatidylcholine439.8SELE, PPARG, SOAT1, CCL2, LPA, ALOX12
39cycloheximide439.8HMGCR, ALOX5, ALOX12, PPARG, SELE, SOAT1
40nitric oxide43 24 1211.8SELE, LPA, CCL2, ALOX12, ALOX15, OLR1
41arginine439.8SAA1, LPA, CCL2, ALOX5, HMGCR, OLR1
425 aminosalicylic acid439.8PPARG, CCL2, ALOX5
43fibrinogen439.8SELE, SAA1, LPA, CCL2, SOAT1
44estrogen439.7PPARG, CTSL, ALOX5, ALOX12, LPA, SAA1
45dexamethasone43 49 28 1212.6MMP3, ALOX12, SOAT1, PPARG, HMGCR, CTSL
46vegf439.5PPARG, SOAT1, SELE, LPA, CCL2, ALOX12
47oxygen43 2410.5MMP3, SOAT1, ALOX12, ALOX5, ALOX15, OLR1
48glucose439.5SAA1, PPARG, LPA, ABCG8, CTSL, OLR1
49cholesterol43 28 24 1212.3ATHS, OLR1, CCL2, SAA1, PPARG, MMP3
50lipid439.1ABCG8, PPARG, ATHS, OLR1, SELE, SOAT1

GO Terms for genes affiliated with Atherosclerosis

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Cellular components related to Atherosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00055769.6SAA1, LPA, CCL2, OLR1, CTSL, MMP3
2extracellular spaceGO:00056159.4CTSL, ALOX5, CCL2, MMP3, PON3, SELE

Biological processes related to Atherosclerosis according to GeneCards Suite gene sharing:

(show all 15)
idNameGO IDScoreTop Affiliating Genes
1lipoxin A4 biosynthetic processGO:0200130310.5ALOX15, ALOX12
2lipoxin metabolic processGO:0200130010.5ALOX5, ALOX12
3hepoxilin biosynthetic processGO:005112210.4ALOX12, ALOX15
4lymphocyte chemotaxisGO:004824710.4CCL2, SAA1
5fatty acid oxidationGO:001939510.4ALOX12, PPARG
6lipoxygenase pathwayGO:001937210.4ALOX15, ALOX5, ALOX12
7arachidonic acid metabolic processGO:001936910.3ALOX15, ALOX5, ALOX12
8response to nutrientGO:000758410.3PPARG, ABCG8, HMGCR
9macrophage chemotaxisGO:004824610.3CCL2, SAA1
10leukocyte cell-cell adhesionGO:000715910.2OLR1, SELE
11leukotriene metabolic processGO:000669110.2ALOX5, ALOX15
12agingGO:000756810.2CCL2, ALOX12, HMGCR
13inflammatory responseGO:000695410.1SELE, CCL2, ALOX15, OLR1
14cholesterol effluxGO:00333449.8SOAT1, ABCG8
15small molecule metabolic processGO:00442819.6ABCG8, LPA, ALOX12, ALOX5, ALOX15, HMGCR

Molecular functions related to Atherosclerosis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1fibronectin bindingGO:000196810.2CTSL, LPA
2arachidonate 12-lipoxygenase activityGO:000405210.1ALOX15, ALOX12
3iron ion bindingGO:00055069.8ALOX15, ALOX5, ALOX12

Products for genes affiliated with Atherosclerosis

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Sources for Atherosclerosis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet