MCID: ATP001
MIFTS: 68

Atopic Dermatitis malady

Skin diseases, Neuronal diseases, Immune diseases categories

Summaries for Atopic Dermatitis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

MalaCards: Atopic Dermatitis, also known as besnier's prurigo, is related to dermatitis and psoriasis. An important gene associated with Atopic Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs betamethasone and betamethasone acetate and the compounds allergens and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include the skin, skin and t cells.

Wikipedia:63 Atopic dermatitis (AD) also known as atopic eczema or eczema is a type of dermatitis, an inflammatory,... more...

Description from OMIM:46 603165

Aliases & Classifications for Atopic Dermatitis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Neuronal diseases, Immune diseases


Aliases & Descriptions:

atopic dermatitis 8 10
besnier's prurigo 8 60
atopic neurodermatitis 8
atopic dermatitis nos 8
allergic dermatitis 8
dermatitis, atopic 60
allergic eczema 8
dermatitis atopic 44
atopic eczema 8


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Disease Ontology8 DOID:3310
MeSH34 D003876
OMIM46 603165
ICD1025 L20, L20.0

Related Diseases for Atopic Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Atopic Dermatitis family:

Dermatitis, Atopic 2 Dermatitis, Atopic 1
Dermatitis, Atopic 6 Dermatitis, Atopic 7
Dermatitis, Atopic 5 Dermatitis, Atopic 4
Dermatitis, Atopic 3

Diseases related to Atopic Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.5TSLP, IL5, IL31, IL13, IGHE, FLG
2psoriasis31.4KLK7, CCL22, CCL11, IL5, CCL18, CCL17
3asthma31.2CCL11, IL13
4contact dermatitis31.1FLG, IGHE, IL5
5food allergy31.0CCL11, IGHE, RNASE3, IL13, IL5
6skin disease31.0CCL11, KLK7, CCL18, HRH1, IL5, IL31
7eczema herpeticum31.0IGHE, TSLP
8allergic contact dermatitis30.8CCL27, FLG, IL5
9eosinophilia30.8CCL11, CCL17, CCL27, IGHE, RNASE3, IL13
10allergic asthma30.7CCL11, CCL17, FLG, TSLP, HRH1, IL5
11rhinitis30.7HRH1, IL5, IL13, RNASE3, IGHE, CCL11
12urticaria30.7HRH1, RNASE3, IGHE
13egg allergy30.6IGHE, IL5
14allergic rhinitis30.6CCL11, IGHE, RNASE3, IL13, IL5, HRH1
15keratoconjunctivitis30.5IL5, IL13, RNASE3, CCL11
16arthritis30.5IL13, FLG
17rheumatoid arthritis30.4CCL11, CCL18, CCL27, FLG, RNASE3, IL13
18netherton syndrome30.4TSLP, IGHE, KLK7
19allergic conjunctivitis30.3HRH1, IL5, IL13, RNASE3, IGHE, CCL11
20bronchitis30.3CCL11, IGHE, RNASE3, IL5
21conjunctivitis30.3HRH1, RNASE3, IGHE
22eosinophilic gastroenteritis30.1CCL11, IGHE, IL5
23bullous pemphigoid30.0CCL11, CCL17, FLG, IGHE, RNASE3, IL13
24pneumonia30.0CCL22, CCL11, CCL18, CCL17, IL13, IL5
25pulmonary eosinophilia30.0CCL11, IGHE, RNASE3, IL13, IL5
26mycosis fungoides30.0CCL22, CCL17, CCL27, IL5
27malaria30.0HRH1
28allergic bronchopulmonary aspergillosis30.0IGHE, IL5
29multiple sclerosis30.0CCL11, CCL27, IL13, IL5
30ichthyosis vulgaris10.7
31impetigo10.5
32irritant dermatitis10.5
33alopecia10.4
34cutaneous t cell lymphoma10.4
35molluscum contagiosum10.4
36vaccinia10.4
37neurodermatitis10.4
38lichen planus10.4
39alopecia areata10.4
40vitiligo10.3
41acne10.3
42herpes simplex10.3
43retinitis10.3
44root resorption10.2
45rosacea10.2
46wiskott-aldrich syndrome10.2
47pityriasis versicolor10.2
48ritter's disease10.2
49primary cutaneous amyloidosis10.2
50protein-losing enteropathy10.2

Graphical network of the top 20 diseases related to Atopic Dermatitis:



Diseases related to atopic dermatitis

Clinical Features for Atopic Dermatitis

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46OMIM
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Clinical features from OMIM:

603165

Drugs & Therapeutics for Atopic Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Atopic Dermatitis

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Anatomical Context for Atopic Dermatitis

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32MalaCards, 14FMA
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MalaCards organs/tissues related to Atopic Dermatitis:

32
Skin, T cells, Testes, Monocytes, Colon, Thymus, B cells, Breast, Endothelial, Whole blood, Liver, Bone, Myeloid, Thyroid, Kidney, Tonsil

FMA organs/tissues related to Atopic Dermatitis:

14
The skin

Animal Models for Atopic Dermatitis or affiliated genes

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Publications for Atopic Dermatitis

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50PubMed
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Articles related to Atopic Dermatitis:

(show top 50)    (show all 1724)
idTitleAuthorsYear
1
Histamine H4 Receptor Antagonists Ineffective against Itch and Skin Inflammation in Atopic Dermatitis Mouse Model. (23962807)
2014
2
Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model. (23149290)
2013
3
Genotyping of Malassezia pachydermatis isolates from canine healthy skin and lesional skin of atopic dermatitis in Japan, Korea and Taiwan. (23411408)
2013
4
Severe refractory atopic dermatitis in an adolescent patient successfully treated with ustekinumab. (24003284)
2013
5
Generalized orf superinfection in a child with atopic dermatitis. (24047581)
2013
6
Gastrointestinal hemodynamics in dogs with nonfood induced atopic dermatitis. (23551746)
2013
7
Adherence to a five day treatment course of topical fluocinonide 0.1% cream in atopic dermatitis. (24139369)
2013
8
Relationship between serum eotaxins level and their genes expression in skin of atopic dermatitis patients. (23706717)
2013
9
Vitamin D level in children is correlated with severity of atopic dermatitis but only in patients with allergic sensitizations. (23289912)
2013
10
Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis. (23777851)
2013
11
Coexistence of allergic bronchopulmonary aspergillosis and atopic dermatitis: is total IgE level useful to identify relapses of allergic bronchopulmonary aspergillosis? (23026291)
2013
12
Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis. (21790526)
2012
13
Ciclosporin therapy is associated with minimal changes in calcium metabolism in dogs with atopic dermatitis. (23140314)
2012
14
Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring. (21294778)
2011
15
Reductions in claudin-1 may enhance susceptibility to herpes simplex virus 1 infections in atopic dermatitis. (21489616)
2011
16
Erythrodermic cutaneous T-cell lymphoma: how to differentiate this rare disease from atopic dermatitis. (21872448)
2011
17
Atopic dermatitis - current insights into path physiology and management]. (20336617)
2010
18
Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization. (20107184)
2010
19
Diagnostic approach to the hyper-IgE syndromes: immunologic and clinical key findings to differentiate hyper-IgE syndromes from atopic dermatitis. (20816194)
2010
20
Expression of COUP-TF-interacting protein 2 (CTIP2) in human atopic dermatitis and allergic contact dermatitis skin. (19366371)
2009
21
Serum mucosa-associated epithelial chemokine (MEC/CCL28) in atopic dermatitis: a specific marker for severity. (19659860)
2009
22
Association analysis of sphingomyelinase 2 polymorphisms for the extrinsic type of atopic dermatitis in Koreans. (17212982)
2007
23
The comparative effects of tacrolimus and hydrocortisone in adult atopic dermatitis: an immunohistochemical study. (17223872)
2007
24
IgE values and T-lymphocyte subsets in children with atopic eczema/dermatitis syndrome. (18034970)
2007
25
Filaggrin loss-of-function variant contributes to atopic dermatitis risk in the population of Northern Germany. (17034559)
2006
26
Etiopathogenesis of atopic dermatitis--an overview. (15788148)
2005
27
Atopy patch test reaction to airborne allergens in the diagnosis of atopic dermatitis. (15788141)
2005
28
Tumour necrosis factor-alpha but not interferon-gamma is the main inducer of inducible protein-10 in skin fibroblasts from patients with atopic dermatitis. (15149503)
2004
29
Gene expression of enzymes for tryptophan degradation pathway is upregulated in the skin lesions of patients with atopic dermatitis or psoriasis. (15541637)
2004
30
Impaired interferon-gamma production in a subset population of severe atopic dermatitis. (15178894)
2004
31
Polymorphisms in the promoter of the interleukin-4 receptor alpha chain gene are associated with atopic dermatitis in Japan. (15086575)
2004
32
Dendritic cells and atopic eczema/dermatitis syndrome. (14501434)
2003
33
Atopic dermatitis as a side effect of anti-tumor necrosis factor-alpha therapy. (14677200)
2003
34
Characterization of chemokine receptor expression and cytokine production in circulating CD4+ T cells from patients with atopic dermatitis: up-regulation of C-C chemokine receptor 4 in atopic dermatitis. (12190665)
2002
35
Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia. (11480592)
2001
36
Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. (11240957)
2001
37
Expression of VCAM-1, ICAM-1, E-selectin, and P-selectin on endothelium in situ in patients with erythroderma, mycosis fungoides and atopic dermatitis. (11028813)
2000
38
Heterogeneity of dermal deposition of eosinophil granule major basic protein in acute lesions of atopic dermatitis. (10749555)
2000
39
Reduced production of both Th1 and Tc1 lymphocyte subsets in atopic dermatitis (AD). (9933413)
1999
40
The quantitative and qualitative defect of CD4+ CD45RO+ memory-type T cells are involved in the abnormality of TH1 immunity in atopic dermatitis patients. (10231330)
1999
41
Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients. (9856836)
1998
42
Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice. (9088984)
1997
43
Interleukin-4 production in Epstein-Barr virus-transformed B cell lines from peripheral mononuclear cells of patients with atopic dermatitis. (9355960)
1997
44
Monocyte phosphodiesterase abnormalities and dysregulation of lymphocyte function in atopic dermatitis. (7616004)
1995
45
Production and secretion of interferon-gamma (IFN-gamma) in children with atopic dermatitis. (8287610)
1994
46
Eosinophil migration in atopic dermatitis. I: Increased migratory responses to N-formyl-methionyl-leucyl-phenylalanine, neutrophil-activating factor, platelet-activating factor, and platelet factor 4. (8429236)
1993
47
Effects of Staphylococcus aureus cell wall products (teichoic acid, peptidoglycan) and enterotoxin B on immunoglobulin (IgE, IgA, IgG) synthesis and CD23 expression in patients with atopic dermatitis. (1531645)
1992
48
Thymopentin treatment in severe atopic dermatitis--clinical and immunological evaluations. (1329673)
1992
49
Interferon-gamma production in atopic dermatitis: a role for prostaglandins? (1483067)
1992
50
Evidence that defective interferon-gamma production in atopic dermatitis patients is due to intrinsic abnormalities. (2107991)
1990

Genetic Variations for Atopic Dermatitis

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Expression for genes affiliated with Atopic Dermatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atopic Dermatitis

Search GEO for disease gene expression data for Atopic Dermatitis.

Pathways for genes affiliated with Atopic Dermatitis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Pathways related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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11.5TSLP, CCL22, CCL11, CCL18, CCL17, CCL27
2
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11.4IL13, CCL27, CCL17, CCL18, CCL11, CCL22
3
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11.4CCL22, CCL11, CCL18, CCL17, CCL27, IL13
4
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11.4CCL22, CCL11, CCL18, CCL17, CCL27, IL13
5
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11.1CCL22, CCL11, CCL17, CCL27, HRH1
6
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11.1CCL22, CCL18, CCL17, NACA, IL5
7
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11.1CCL27, CCL17, CCL18, CCL11, CCL22
8
Hide members
11.1CCL22, CCL11, CCL18, CCL17, CCL27
9
Hide members
11.0CCL11, RNASE3, IL13, IL5
1011.0CCL11, CCL17, IGHE, IL5
1111.0CCL22, CCL11, CCL17, CCL27
12
Hide members
11.0IL5, IL13, IGHE, CCL11
1310.7IL5, IL13

Compounds for genes affiliated with Atopic Dermatitis

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1allergens4412.2HRH1, IL5, IL13, RNASE3, FLG, CCL17
2dexamethasone44 49 28 1115.2CCL11, RNASE3, IGHE, CCL27, CCL17, CCL18
3tarc4412.1IGHE, CCL18, CCL11, CCL22, CCL27, CCL17
4histamine44 28 2413.9HRH1, IL31, IL13, RNASE3, IL5, IGHE
5cyclosporin a44 28 5913.9IL13, IL5, CCL22, HRH1, CCL11, CCL17
6pge24411.7HRH1, IL5, IL13, CCL22, CCL11, CCL27
7methacholine44 1112.7RNASE3, CCL11, IL13, CCL22, IGHE, IL5
8ccl344 2812.7IL13, CCL17, CCL11, CCL18, CCL22, CCL27
9ccl444 2812.7CCL11, IL13, CCL27, CCL17, CCL18, CCL22
10tacrolimus44 49 1113.6CCL11, CCL17, IL13, IL5, HRH1, CCL22
11sodium cromoglycate4411.5HRH1, IGHE, CCL11, IL5, RNASE3
12cetirizine44 28 11 2414.5IL5, RNASE3, HRH1, IGHE, CCL11
13ketotifen44 1112.5IGHE, RNASE3, IL5, HRH1, CCL11
14montelukast44 49 28 1114.5IGHE, RNASE3, IL13, IL5, CCL11
15budesonide44 49 1113.5IL13, IL5, RNASE3, CCL11, IGHE
16salbutamol44 49 28 11 2415.5RNASE3, IGHE, CCL11, IL5, IL13
17fluticasone propionate44 49 59 1114.5RNASE3, IL5, IL13, IGHE, CCL11
18pgd24411.5IL5, IL13, RNASE3, IGHE, CCL11
19leukotriene b444 59 2413.4CCL22, CCL11, RNASE3, IL13, IL5
20unicap4411.4RNASE3, CCL11, IL5, IGHE
21prednisolone44 28 1113.4IL13, IGHE, CCL11, RNASE3, IL5
22anti-histamine4411.4HRH1, RNASE3, CCL11, IGHE
23nedocromil sodium4411.4RNASE3, IGHE, IL5, HRH1
24praziquantel44 1112.4IL5, IGHE, RNASE3, IL13
25salmeterol44 49 28 1114.4RNASE3, IL13, IL5, CCL11
26azelastine44 1112.4IL5, HRH1, IGHE, RNASE3
27ltd44411.3HRH1, IL5, IL13, RNASE3
28ltc44411.3RNASE3, CCL11, IL13, IL5
29rantes4411.3HRH1, CCL11, RNASE3
30clemastine fumarate5911.2HRH1, DHX8, DHX34
31mepyramine maleate5911.2DHX8, DHX34, HRH1
32histamine dihydrochloride5911.2DHX8, DHX34, HRH1
332-pyridylethylamine dihydrochloride5911.2DHX8, DHX34, HRH1
34omalizumab44 1112.2IGHE, IL13, IL5
35oxatomide4411.2IGHE, IL5, HRH1
36levocabastine44 28 1113.2HRH1, IL5, RNASE3
37beclomethasone dipropionate4411.1RNASE3, IGHE, IL5
38ovomucoid4411.1IL5, IL13, IGHE
39toluene diisocyanate4411.1RNASE3, IL5, IGHE
40lte44411.1RNASE3, CCL11, IL5
41capsaicin44 2812.1HRH1, IGHE, RNASE3, IL5
42astemizole44 59 28 1114.1DHX34, DHX8, HRH1
43desloratadine44 1112.1IL13, IGHE, HRH1
44olopatadine44 1112.0IGHE, CCL17, HRH1
45aspirin44 49 28 2414.0IL13, RNASE3, CCL11, HRH1, CCL22
46roxithromycin44 28 1113.0CCL17, CCL11, IL5
47loratadine44 11 2412.9HRH1, RNASE3, IGHE
48pranlukast44 28 1112.9CCL11, RNASE3, IL5
49larc4410.9CCL22, CCL18, CCL17
50penicillin4410.6IL5, IGHE, IL13

GO Terms for genes affiliated with Atopic Dermatitis

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16Gene Ontology
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Cellular components related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.6CCL22, CCL11, CCL17, CCL27, IGHE, RNASE3
2extracellular spaceGO:00561511.3TSLP, CCL22, CCL11, CCL18, CCL17, CCL27

Biological processes related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.5IL5, CCL22, CCL11, CCL18, CCL17, CCL27
2inflammatory responseGO:00695411.4CCL22, CCL11, CCL18, CCL17, IL13, IL5
3chemotaxisGO:00693511.0CCL22, CCL11, CCL18, CCL17, CCL27
4cell-cell signalingGO:00726710.8IL13, CCL27, CCL17, CCL18, CCL22
5eosinophil chemotaxisGO:04824510.7HRH1, CCL11

Molecular functions related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.0TSLP, IL5, IL31, IL13
2chemokine activityGO:00800910.8CCL27, CCL17, CCL18, CCL11, CCL22

Products for genes affiliated with Atopic Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopic Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet