MCID: ATP001
MIFTS: 68

Atopic Dermatitis malady

Skin diseases, Neuronal diseases, Immune diseases categories

Summaries for Atopic Dermatitis

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8Disease Ontology, 63Wikipedia, 46OMIM, 32MalaCards
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Disease Ontology:8 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

MalaCards: Atopic Dermatitis, also known as besnier's prurigo, is related to dermatitis and psoriasis. An important gene associated with Atopic Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs betamethasone and betamethasone acetate and the compounds allergens and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include the skin, skin and t cells.

Wikipedia:63 Atopic dermatitis (AD) also known as atopic eczema or eczema is a type of dermatitis, an inflammatory,... more...

Description from OMIM:46 603165

Aliases & Classifications for Atopic Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 60UMLS, 44Novoseek, 56SNOMED-CT, 34MeSH, 46OMIM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Neuronal diseases, Immune diseases


Aliases & Descriptions:

atopic dermatitis 8 10
besnier's prurigo 8 60
atopic neurodermatitis 8
atopic dermatitis nos 8
allergic dermatitis 8
dermatitis, atopic 60
allergic eczema 8
dermatitis atopic 44
atopic eczema 8


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Disease Ontology8 DOID:3310
MeSH34 D003876
OMIM46 603165
ICD1025 L20, L20.0

Related Diseases for Atopic Dermatitis

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Sources:
17GeneCards, 18GeneDecks
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Diseases in the Atopic Dermatitis family:

Dermatitis, Atopic 2 Dermatitis, Atopic 1
Dermatitis, Atopic 6 Dermatitis, Atopic 7
Dermatitis, Atopic 5 Dermatitis, Atopic 4
Dermatitis, Atopic 3

Diseases related to Atopic Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 220)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.5TSLP, IL5, IL31, IL13, IGHE, FLG
2psoriasis31.4KLK7, CCL22, CCL11, IL5, CCL18, CCL17
3asthma31.2CCL11, IL13
4contact dermatitis31.1FLG, IGHE, IL5
5food allergy31.0CCL11, IGHE, RNASE3, IL13, IL5
6skin disease31.0CCL11, KLK7, CCL18, HRH1, IL5, IL31
7eczema herpeticum31.0IGHE, TSLP
8allergic contact dermatitis30.8CCL27, FLG, IL5
9eosinophilia30.8CCL11, CCL17, CCL27, IGHE, RNASE3, IL13
10allergic asthma30.7CCL11, CCL17, FLG, TSLP, HRH1, IL5
11rhinitis30.7HRH1, IL5, IL13, RNASE3, IGHE, CCL11
12urticaria30.7HRH1, RNASE3, IGHE
13egg allergy30.6IGHE, IL5
14allergic rhinitis30.6CCL11, IGHE, RNASE3, IL13, IL5, HRH1
15keratoconjunctivitis30.5IL5, IL13, RNASE3, CCL11
16arthritis30.5IL13, FLG
17rheumatoid arthritis30.4CCL11, CCL18, CCL27, FLG, RNASE3, IL13
18netherton syndrome30.4TSLP, IGHE, KLK7
19allergic conjunctivitis30.3HRH1, IL5, IL13, RNASE3, IGHE, CCL11
20bronchitis30.3CCL11, IGHE, RNASE3, IL5
21conjunctivitis30.3HRH1, RNASE3, IGHE
22eosinophilic gastroenteritis30.1CCL11, IGHE, IL5
23bullous pemphigoid30.0CCL11, CCL17, FLG, IGHE, RNASE3, IL13
24pneumonia30.0CCL22, CCL11, CCL18, CCL17, IL13, IL5
25pulmonary eosinophilia30.0CCL11, IGHE, RNASE3, IL13, IL5
26mycosis fungoides30.0CCL22, CCL17, CCL27, IL5
27malaria30.0HRH1
28allergic bronchopulmonary aspergillosis30.0IGHE, IL5
29multiple sclerosis30.0CCL11, CCL27, IL13, IL5
30ichthyosis vulgaris10.7
31impetigo10.5
32irritant dermatitis10.5
33alopecia10.4
34cutaneous t cell lymphoma10.4
35molluscum contagiosum10.4
36vaccinia10.4
37neurodermatitis10.4
38lichen planus10.4
39alopecia areata10.4
40vitiligo10.3
41acne10.3
42herpes simplex10.3
43retinitis10.3
44root resorption10.2
45rosacea10.2
46wiskott-aldrich syndrome10.2
47pityriasis versicolor10.2
48ritter's disease10.2
49primary cutaneous amyloidosis10.2
50protein-losing enteropathy10.2

Graphical network of the top 20 diseases related to Atopic Dermatitis:



Diseases related to atopic dermatitis

Clinical Features for Atopic Dermatitis

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46OMIM
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Clinical features from OMIM:

603165

Drugs & Therapeutics for Atopic Dermatitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Genetic Tests for Atopic Dermatitis

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Anatomical Context for Atopic Dermatitis

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Sources:
32MalaCards, 14FMA
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MalaCards organs/tissues related to Atopic Dermatitis:

32
Skin, T cells, Testes, Monocytes, Colon, Thymus, B cells, Breast, Endothelial, Whole blood, Liver, Bone, Thyroid, Tonsil, Myeloid, Kidney

FMA organs/tissues related to Atopic Dermatitis:

14
The skin

Animal Models for Atopic Dermatitis or affiliated genes

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Publications for Atopic Dermatitis

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50PubMed
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Articles related to Atopic Dermatitis:

(show top 50)    (show all 1724)
idTitleAuthorsYear
1
Atopic dermatitis-like presentation of graft-versus-host disease: a novel form of chronic cutaneous graft-versus-host disease. (23375455)
2013
2
The epithelial cell-derived atopic dermatitis cytokine TSLP activates neurons to induce itch. (24094650)
2013
3
Moisturizers for patients with atopic dermatitis. (23859407)
2013
4
Staphylococcus aureus genomic pattern and atopic dermatitis: may factors other than superantigens be involved? (24162256)
2013
5
Role of fibroblasts in the pathogenesis of atopic dermatitis. (23582515)
2013
6
Skin-protective effects of a zinc oxide-functionalized textile and its relevance for atopic dermatitis. (23696710)
2013
7
Comparison of sertaconazole 2% cream versus hydrocortisone 1% ointment in the treatment of atopic dermatitis. (23470235)
2013
8
Staphylococcus aureus Colonization in Acute and Chronic Skin Lesions of Patients with Atopic Dermatitis. (24371386)
2013
9
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis. (22197932)
2012
10
Dermatophagoides farinae house dust mite allergen challenges reduce stratum corneum ceramides in an experimental dog model of acute atopic dermatitis. (23140315)
2012
11
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population. (23042114)
2012
12
Pentraxin 3 serum levels in children with atopic dermatitis. (22691256)
2012
13
Association of single nucleotide polymorphism of interleukin-18 with atopic dermatitis. (19453784)
2010
14
Raman profiles of the stratum corneum define 3 filaggrin genotype-determined atopic dermatitis endophenotypes. (20621340)
2010
15
Association of single nucleotide polymorphisms in the IL-12 (IL-12A and B) and IL-12 receptor (IL-12Rbeta1 and beta2) genes and gene-gene interactions with atopic dermatitis in Koreans. (20060272)
2010
16
Plasma fibrin clot properties in atopic dermatitis: links between thrombosis and atopy. (20419337)
2010
17
Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis. (20236835)
2010
18
Injury downregulates the expression of the human cathelicidin protein hCAP18/LL-37 in atopic dermatitis. (19645825)
2010
19
Polymorphisms within the C3 gene are associated with specific IgE levels to common allergens and super-antigens among atopic dermatitis patients. (18631248)
2009
20
Staphylococcus aureus skin colonization in atopic dermatitis children is associated with decreased IFN-gamma production by peripheral blood CD4+ and CD8+ T cells. (17662038)
2008
21
Variation in genes encoding eosinophil granule proteins in atopic dermatitis patients from Germany. (19014520)
2008
22
Quantitation of canine regulatory T cell populations, serum interleukin-10 and allergen-specific IgE concentrations in healthy control dogs and canine atopic dermatitis patients receiving allergen-specific immunotherapy. (18423890)
2008
23
Microanalysis of an antimicrobial peptide, beta-defensin-2, in the stratum corneum from patients with atopic dermatitis. (18476959)
2008
24
Suppression of skin lesions by transdermal application of CpG-oligodeoxynucleotides in NC/Nga mice, a model of human atopic dermatitis. (17182599)
2007
25
Serum eosinophil cationic protein in children with atopic dermatitis. (17040428)
2006
26
Increase in macrophage migration inhibitory factor levels in lacrimal fluid of patients with severe atopic dermatitis. (16331484)
2006
27
Plasma levels of polyunsaturated fatty acids in children with atopic dermatitis and in atopic and nonatopic controls. (16091876)
2005
28
Effectiveness of specific immunotherapy in the treatment of children and youngsters suffering from atopic dermatitis. Part III. Serum concentrations of selected immunologic parameters]. (16238119)
2005
29
Acquired symmetrical dermal melanocytosis (naevus of Hori) developing after aggravated atopic dermatitis. (15888144)
2005
30
The presence of CD30 on lymphocytes in the inflammatory infiltrate of acute atopic dermatitis]. (16082884)
2004
31
Proximal promoter polymorphisms of the interleukin-4 receptor alpha are associated with psoriasis in Japan: inverse association pattern compared with atopic dermatitis. (15194153)
2004
32
Association of cathepsin E deficiency with development of atopic dermatitis. (14769879)
2003
33
HLA-DR-dependent increased mannan-induced lymphoproliferative response in atopic eczema dermatitis syndrome. (12580811)
2003
34
Association between novel GM-CSF gene polymorphisms and the frequency and severity of atopic dermatitis. (13679820)
2003
35
Intracellular 3',5'-adenosine cyclic monophosphate level regulates house dust mite-induced interleukin-13 production by T cells from mite-sensitive patients with atopic dermatitis. (11168792)
2001
36
Intraocular lens subluxation in a patient with facial atopic dermatitis. (11226805)
2001
37
Association between atopic dermatitis and insulin-dependent diabetes mellitus: a case-control study. (11403811)
2001
38
An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). (10887320)
2000
39
Toward a canine model of atopic dermatitis: amplification of cytokine-gene transcripts in the skin of atopic dogs. (10389638)
1999
40
Evaluation of the staphylococcal exotoxins and their specific IgE in childhood atopic dermatitis. (10452768)
1999
41
Linkage and association of an interleukin 4 gene polymorphism with atopic dermatitis in Japanese families. (9643293)
1998
42
In vivo expression of cytokine receptor mRNA in atopic dermatitis. (9723668)
1998
43
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis. (9028795)
1996
44
Production of interleukin-5 and the suppressive effect of cyclosporin A in childhood severe atopic dermatitis. (8551410)
1996
45
Interferon-alpha treatment for severe atopic dermatitis. (8607568)
1995
46
Enhancement of IgE production by anti-CD40 antibody in atopic dermatitis. (7512104)
1994
47
E-selectin and vascular cell adhesion molecule-1 as critical adhesion molecules for infiltration of T lymphocytes and eosinophils in atopic dermatitis. (7514618)
1994
48
The detection of IgE-secreting cells in the peripheral blood of patients with atopic dermatitis. (1560170)
1992
49
Serum eosinophil cationic protein (ECP) is a sensitive measure for disease activity in atopic dermatitis. (1571256)
1992
50
CD4+ memory T cells in peripheral blood are not decreased in patients with atopic dermatitis. (1675611)
1991

Genetic Variations for Atopic Dermatitis

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Expression for genes affiliated with Atopic Dermatitis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atopic Dermatitis

Search GEO for disease gene expression data for Atopic Dermatitis.

Pathways for genes affiliated with Atopic Dermatitis

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Sources:
51QIAGEN, 29KEGG, 53Reactome, 37NCBI BioSystems Database, 12EMD Millipore, 52R&D Systems
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Pathways related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5TSLP, CCL22, CCL11, CCL18, CCL17, CCL27
2
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11.4IL13, CCL27, CCL17, CCL18, CCL11, CCL22
3
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11.4CCL22, CCL11, CCL18, CCL17, CCL27, IL13
4
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11.4CCL22, CCL11, CCL18, CCL17, CCL27, IL13
5
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11.1CCL22, CCL11, CCL17, CCL27, HRH1
6
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11.1CCL22, CCL18, CCL17, NACA, IL5
7
Hide members
11.1CCL27, CCL17, CCL18, CCL11, CCL22
8
Hide members
11.1CCL22, CCL11, CCL18, CCL17, CCL27
9
Hide members
11.0CCL11, RNASE3, IL13, IL5
1011.0CCL11, CCL17, IGHE, IL5
1111.0CCL22, CCL11, CCL17, CCL27
12
Hide members
11.0IL5, IL13, IGHE, CCL11
1310.7IL5, IL13

Compounds for genes affiliated with Atopic Dermatitis

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience
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Compounds related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1allergens4412.2HRH1, IL5, IL13, RNASE3, FLG, CCL17
2dexamethasone44 49 28 1115.2CCL11, RNASE3, IGHE, CCL27, CCL17, CCL18
3tarc4412.1IGHE, CCL18, CCL11, CCL22, CCL27, CCL17
4histamine44 28 2413.9HRH1, IL31, IL13, RNASE3, IL5, IGHE
5cyclosporin a44 28 5913.9IL13, IL5, CCL22, HRH1, CCL11, CCL17
6pge24411.7HRH1, IL5, IL13, CCL22, CCL11, CCL27
7methacholine44 1112.7RNASE3, CCL11, IL13, CCL22, IGHE, IL5
8ccl344 2812.7IL13, CCL17, CCL11, CCL18, CCL22, CCL27
9ccl444 2812.7CCL11, IL13, CCL27, CCL17, CCL18, CCL22
10tacrolimus44 49 1113.6CCL11, CCL17, IL13, IL5, HRH1, CCL22
11sodium cromoglycate4411.5HRH1, IGHE, CCL11, IL5, RNASE3
12cetirizine44 28 11 2414.5IL5, RNASE3, HRH1, IGHE, CCL11
13ketotifen44 1112.5IGHE, RNASE3, IL5, HRH1, CCL11
14montelukast44 49 28 1114.5IGHE, RNASE3, IL13, IL5, CCL11
15budesonide44 49 1113.5IL13, IL5, RNASE3, CCL11, IGHE
16salbutamol44 49 28 11 2415.5RNASE3, IGHE, CCL11, IL5, IL13
17fluticasone propionate44 49 59 1114.5RNASE3, IL5, IL13, IGHE, CCL11
18pgd24411.5IL5, IL13, RNASE3, IGHE, CCL11
19leukotriene b444 59 2413.4CCL22, CCL11, RNASE3, IL13, IL5
20unicap4411.4RNASE3, CCL11, IL5, IGHE
21prednisolone44 28 1113.4IL13, IGHE, CCL11, RNASE3, IL5
22anti-histamine4411.4HRH1, RNASE3, CCL11, IGHE
23nedocromil sodium4411.4RNASE3, IGHE, IL5, HRH1
24praziquantel44 1112.4IL5, IGHE, RNASE3, IL13
25salmeterol44 49 28 1114.4RNASE3, IL13, IL5, CCL11
26azelastine44 1112.4IL5, HRH1, IGHE, RNASE3
27ltd44411.3HRH1, IL5, IL13, RNASE3
28ltc44411.3RNASE3, CCL11, IL13, IL5
29rantes4411.3HRH1, CCL11, RNASE3
30clemastine fumarate5911.2HRH1, DHX8, DHX34
31mepyramine maleate5911.2DHX8, DHX34, HRH1
32histamine dihydrochloride5911.2DHX8, DHX34, HRH1
332-pyridylethylamine dihydrochloride5911.2DHX8, DHX34, HRH1
34omalizumab44 1112.2IGHE, IL13, IL5
35oxatomide4411.2IGHE, IL5, HRH1
36levocabastine44 28 1113.2HRH1, IL5, RNASE3
37beclomethasone dipropionate4411.1RNASE3, IGHE, IL5
38ovomucoid4411.1IL5, IL13, IGHE
39toluene diisocyanate4411.1RNASE3, IL5, IGHE
40lte44411.1RNASE3, CCL11, IL5
41capsaicin44 2812.1HRH1, IGHE, RNASE3, IL5
42astemizole44 59 28 1114.1DHX34, DHX8, HRH1
43desloratadine44 1112.1IL13, IGHE, HRH1
44olopatadine44 1112.0IGHE, CCL17, HRH1
45aspirin44 49 28 2414.0IL13, RNASE3, CCL11, HRH1, CCL22
46roxithromycin44 28 1113.0CCL17, CCL11, IL5
47loratadine44 11 2412.9HRH1, RNASE3, IGHE
48pranlukast44 28 1112.9CCL11, RNASE3, IL5
49larc4410.9CCL22, CCL18, CCL17
50penicillin4410.6IL5, IGHE, IL13

GO Terms for genes affiliated with Atopic Dermatitis

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16Gene Ontology
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Cellular components related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.6CCL22, CCL11, CCL17, CCL27, IGHE, RNASE3
2extracellular spaceGO:00561511.3TSLP, CCL22, CCL11, CCL18, CCL17, CCL27

Biological processes related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.5IL5, CCL22, CCL11, CCL18, CCL17, CCL27
2inflammatory responseGO:00695411.4CCL22, CCL11, CCL18, CCL17, IL13, IL5
3chemotaxisGO:00693511.0CCL22, CCL11, CCL18, CCL17, CCL27
4cell-cell signalingGO:00726710.8IL13, CCL27, CCL17, CCL18, CCL22
5eosinophil chemotaxisGO:04824510.7HRH1, CCL11

Molecular functions related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.0TSLP, IL5, IL31, IL13
2chemokine activityGO:00800910.8CCL27, CCL17, CCL18, CCL11, CCL22

Products for genes affiliated with Atopic Dermatitis

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  • Antibodies
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Sources for Atopic Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet