MCID: ATP001
MIFTS: 64

Atopic Dermatitis malady

Skin, Neuronal, Immune categories

Summaries for Atopic Dermatitis

Sources:
8Disease Ontology, 64Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

MalaCards: Atopic Dermatitis, also known as besnier's prurigo, is related to asthma and atopy. An important gene associated with Atopic Dermatitis is CCL11 (chemokine (C-C motif) ligand 11), and among its related pathways are PEDF Induced Signaling and Akt Signaling. The drugs betamethasone and betamethasone acetate and the compounds allergens and dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include the skin, whole blood and thymus.

Wikipedia:64 Atopic eczema also known as atopic dermatitis is a type of eczema, an inflammatory, relapsing,... more...

Description from OMIM:47 603165

Aliases & Classifications for Atopic Dermatitis

Sources:
8Disease Ontology, 10DISEASES, 61UMLS, 45Novoseek, 57SNOMED-CT, 35MeSH, 47OMIM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin, Neuronal, Immune


Aliases & Descriptions:

atopic dermatitis 8 10
besnier's prurigo 8 61
atopic neurodermatitis 8
atopic dermatitis nos 8
allergic dermatitis 8
dermatitis, atopic 61
allergic eczema 8
dermatitis atopic 45
atopic eczema 8


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Disease Ontology8 DOID:3310
MeSH35 D003876
OMIM47 603165
ICD1025 L20, L20.0

Related Diseases for Atopic Dermatitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Atopic Dermatitis family:

dermatitis, atopic 2 dermatitis, atopic 1
dermatitis, atopic 6 dermatitis, atopic 7
dermatitis, atopic 5 dermatitis, atopic 4
dermatitis, atopic 3

Diseases related to Atopic Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 221)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.3CCL11, IL13
2atopy31.1RNASE3, IGHE, FLG, CCL17, CCL11, CCL22
3eczema herpeticum31.0IGHE, TSLP
4allergic contact dermatitis30.8CCL27, FLG, IL5
5allergic asthma30.7CCL11, CCL17, FLG, TSLP, HRH1, IL5
6urticaria30.7HRH1, RNASE3, IGHE
7allergic rhinitis30.6CCL11, IGHE, RNASE3, IL13, IL5, HRH1
8arthritis30.5IL13, FLG
9netherton syndrome30.4TSLP, IGHE, KLK7
10allergic conjunctivitis30.3HRH1, IL5, IL13, RNASE3, IGHE, CCL11
11bronchitis30.3CCL11, IGHE, RNASE3, IL5
12pulmonary disease, chronic obstructive30.3IL13, RNASE3, CCL11
13eosinophilic gastroenteritis30.2CCL11, IGHE, IL5
14bullous pemphigoid30.1CCL11, CCL17, FLG, IGHE, RNASE3, IL13
15vernal keratoconjunctivitis30.1CCL11, IGHE, RNASE3, IL13, IL5
16helminthiasis30.1IGHE, RNASE3, IL13, IL5
17mycosis fungoides30.1CCL22, CCL17, CCL27, IL5
18allergic bronchopulmonary aspergillosis30.1IGHE, IL5
19dermatitis, atopic 110.7
20ichthyosis vulgaris10.7
21dermatitis, atopic 210.5
22n syndrome10.5
23dermatitis, atopic 310.5
24alopecia10.5
25molluscum contagiosum10.4
26vaccinia10.4
27neurodermatitis10.4
28lichen planus10.4
29alopecia areata10.4
30chronic actinic dermatitis10.4
31vitiligo10.4
32dermatitis, atopic 410.4
33atopic keratoconjunctivitis10.4
34acne10.3
35root resorption10.2
36rosacea10.2
37wiskott-aldrich syndrome10.2
38pityriasis versicolor10.2
39ritter's disease10.2
40primary cutaneous amyloidosis10.2
41protein-losing enteropathy10.2
42kaposi's sarcoma10.2
43toxic shock syndrome10.2
44olecranon bursitis10.2
45amyloidosis10.2
46brain disease10.2
47transient hypogammaglobulinemia10.2
48xanthomatosis10.2
49short stature10.2
50dermatitis, atopic 710.2

Graphical network of the top 20 diseases related to Atopic Dermatitis:



Diseases related to atopic dermatitis

Clinical Features for Atopic Dermatitis

Sources:
47OMIM
See all sources

Clinical features from OMIM:

603165

Drugs & Therapeutics for Atopic Dermatitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Atopic Dermatitis

Anatomical Context for Atopic Dermatitis

Sources:
14FMA, 33MalaCards
See all sources

MalaCards organs/tissues related to Atopic Dermatitis:

33
Whole blood, Thymus, Brain, Small intestine, Colon, Kidney, Liver, Thyroid, Breast, Skin, Tonsil, Myeloid, Monocytes, T cells, B cells, Endothelial, Bronchial epithelium

FMA organs/tissues related to Atopic Dermatitis:

14
The skin

Animal Models for Atopic Dermatitis or affiliated genes

Sources:
28inGenious Targeting Laboratory
See all sources

Publications for Atopic Dermatitis

Sources:
51PubMed
See all sources

Articles related to Atopic Dermatitis:

(show top 50)    (show all 1724)
idTitleAuthorsYear
1
Nonpathogenic Bacteria Alleviating Atopic Dermatitis Inflammation Induce IL-10-Producing Dendritic Cells and Regulatory Tr1 Cells. (23812300)
2014
2
Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-I+/IFN-I^-induced TARC activation in HaCaT cells. (23454147)
2013
3
Effect of dehydroepiandrosterone on atopic dermatitis-like skin lesions induced by 1-chloro-2,4-dinitrobenzene in mouse. (23891346)
2013
4
Kaposi sarcoma in an patient with atopic dermatitis treated with ciclosporin. (24265347)
2013
5
New era of biologic therapeutics in atopic dermatitis. (23323893)
2013
6
Update on the structure and function of the skin barrier: atopic dermatitis as an exemplar of clinical implications. (24156154)
2013
7
A functional IL-6 receptor (IL6R) variant is a risk factor for persistent atopic dermatitis. (23582566)
2013
8
Thymic stromal lymphopoietin expression is increased in the horny layer of patients with atopic dermatitis. (23379440)
2013
9
Aggravation of atopic dermatitis-like symptoms by consecutive low concentration of formaldehyde exposure in NC/Nga mice. (23387407)
2013
10
Atopy as a risk factor for thyroid autoimmunity in children affected with atopic dermatitis. (24118567)
2013
11
Evaluation of the adult patient with atopic dermatitis. (23414536)
2013
12
Therapeutic effects of fermented soycrud on phenotypes of atopic dermatitis induced by phthalic anhydride. (23825483)
2013
13
An international multicenter study on quality of life and family quality of life in children with atopic dermatitis. (23254729)
2013
14
The alkylphenols 4-nonylphenol, 4-tert-octylphenol and 4-tert-butylphenol aggravate atopic dermatitis-like skin lesions in NC/Nga mice. (23983229)
2013
15
Topical calcineurin inhibitors for atopic dermatitis: review and treatment recommendations. (23549982)
2013
16
Genetic variation in the epidermal transglutaminase genes is not associated with atopic dermatitis. (23189155)
2012
17
Retinal degeneration and rd1 mutation in NC/Tnd mice-a human atopic dermatitis model. (21275519)
2011
18
Associations of FLG mutations between ichthyosis vulgaris and atopic dermatitis in Han Chinese. (21496060)
2011
19
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. (19818482)
2010
20
Filaggrin null mutations increase the risk and persistence of hand eczema in subjects with atopic dermatitis: results from a general population study. (20426775)
2010
21
Development of atopic dermatitis in the DARC birth cohort. (19788539)
2010
22
Association between a common IL10 distal promoter haplotype and IgE production in individuals with atopic dermatitis. (19552724)
2009
23
Epidermal barrier function abnormalities in atopic dermatitis caused by filaggrin mutations]. (19444396)
2009
24
Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. (18329087)
2008
25
Low basal serum cortisol in patients with severe atopic dermatitis: potent topical corticosteroids wrongfully accused. (17298484)
2007
26
Clinical significance of serum interleukin-18 concentration in the patients with atopic dermatitis]. (18094564)
2007
27
Risk factors of atopic dermatitis patients for eczema herpeticum. (17170734)
2007
28
Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis. (17291859)
2007
29
Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. (17030248)
2006
30
Cytokine milieu of atopic dermatitis skin subverts the innate immune response to vaccinia virus. (16546102)
2006
31
Netherton syndrome: report of identical twins presenting with severe atopic dermatitis. (16670861)
2006
32
Absence of association between asthma and high serum immunoglobulin E associated GPRA haplotypes and adult atopic dermatitis. (16098057)
2005
33
Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. (15491080)
2004
34
Polymorphism of the mast cell chymase gene (CMA1) promoter region: lack of association with asthma but association with serum total immunoglobulin E levels in adult atopic dermatitis. (15248847)
2004
35
N-acetyltransferase 2 acetylation polymorphism: prevalence of slow acetylators does not differ between atopic dermatitis patients and healthy subjects. (14528063)
2003
36
The effect of suplatast tosilate on the patients with atopic dermatitis--relationship between clinical symptoms and immunological parameters]. (14685038)
2003
37
Endogenous antimicrobial peptides and skin infections in atopic dermatitis. (12374875)
2002
38
Expression of Th1, Th2 and immunosuppressive cytokine gene transcripts in canine atopic dermatitis. (11994107)
2002
39
Analysis of association and linkage for the interleukin-4 and interleukin-4 receptor b;alpha; regions in Swedish atopic dermatitis families. (12190659)
2002
40
Systemic ketoconazole is an effective treatment of atopic dermatitis with IgE-mediated hypersensitivity to yeasts. (11421895)
2001
41
IgE hyperproduction through enhanced tyrosine phosphorylation of Janus kinase 3 in NC/Nga mice, a model for human atopic dermatitis. (9916733)
1999
42
Blood eosinophils and serum IgE as predictors for prognosis of interferon-gamma therapy in atopic dermatitis. (9930598)
1998
43
Predominance of type 2 cytokine-producing CD4+ and CD8+ cells in patients with atopic dermatitis. (9155835)
1997
44
IgE responsiveness to Dermatophagoides farinae in asthma and atopic dermatitis. (9250595)
1997
45
Eosinophil chemiluminescence response to cytokines and opsonized zymosans in atopic dermatitis. (8155999)
1994
46
Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis. (1575548)
1992
47
Study of immune-responsiveness to wheat antigen by IgG, IgA, and IgE immunoblotting with sera from patients with atopic dermatitis. (1476035)
1992
48
Dubowitz syndrome: atopic dermatitis, low birth weight dwarfism and facial dysmorphism. (2358105)
1990
49
Are hyperlinear palms and dry skin signs of a concomitant autosomal ichthyosis vulgaris in atopic dermatitis? (2477977)
1989
50
Tinea capitis masquerading as atopic or seborrheic dermatitis. (155156)
1979

Genetic Variations for Atopic Dermatitis

Expression for genes affiliated with Atopic Dermatitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Atopic Dermatitis

Search GEO for disease gene expression data for Atopic Dermatitis.

Pathways for genes affiliated with Atopic Dermatitis

Sources:
52QIAGEN, 30KEGG, 54Reactome, 38NCBI BioSystems Database, 12EMD Millipore, 53R&D Systems
See all sources

Pathways related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show all 13)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.5TSLP, CCL22, CCL11, CCL18, CCL17, CCL27
2
Hide members
11.4IL13, CCL27, CCL17, CCL18, CCL11, CCL22
3
Hide members
11.4CCL22, CCL11, CCL18, CCL17, CCL27, IL13
4
Hide members
11.4CCL22, CCL11, CCL18, CCL17, CCL27, IL13
5
Hide members
11.1CCL22, CCL11, CCL17, CCL27, HRH1
6
Hide members
11.1CCL22, CCL18, CCL17, NACA, IL5
7
Hide members
11.1CCL27, CCL17, CCL18, CCL11, CCL22
8
Hide members
11.1CCL22, CCL11, CCL18, CCL17, CCL27
9
Hide members
11.0CCL11, RNASE3, IL13, IL5
1011.0CCL11, CCL17, IGHE, IL5
1111.0CCL22, CCL11, CCL17, CCL27
12
Hide members
11.0IL5, IL13, IGHE, CCL11
1310.7IL5, IL13

Compounds for genes affiliated with Atopic Dermatitis

Sources:
45Novoseek, 50PharmGKB, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience
See all sources

Compounds related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show top 50)    (show all 88)
idCompoundScoreTop Affiliating Genes
1allergens4512.2HRH1, IL5, IL13, RNASE3, FLG, CCL17
2dexamethasone45 50 29 1115.2CCL11, RNASE3, IGHE, CCL27, CCL17, CCL18
3tarc4512.1IGHE, CCL18, CCL11, CCL22, CCL27, CCL17
4histamine45 29 2413.9HRH1, IL31, IL13, RNASE3, IL5, IGHE
5cyclosporin a45 29 6013.9IL13, IL5, CCL22, HRH1, CCL11, CCL17
6pge24511.7HRH1, IL5, IL13, CCL22, CCL11, CCL27
7methacholine45 1112.7RNASE3, CCL11, IL13, CCL22, IGHE, IL5
8ccl345 2912.7IL13, CCL17, CCL11, CCL18, CCL22, CCL27
9ccl445 2912.7CCL11, IL13, CCL27, CCL17, CCL18, CCL22
10tacrolimus45 50 1113.6CCL11, CCL17, IL13, IL5, HRH1, CCL22
11sodium cromoglycate4511.5HRH1, IGHE, CCL11, IL5, RNASE3
12cetirizine45 29 11 2414.5IL5, RNASE3, HRH1, IGHE, CCL11
13ketotifen45 1112.5IGHE, RNASE3, IL5, HRH1, CCL11
14montelukast45 50 29 1114.5IGHE, RNASE3, IL13, IL5, CCL11
15budesonide45 50 1113.5IL13, IL5, RNASE3, CCL11, IGHE
16salbutamol45 50 29 11 2415.5RNASE3, IGHE, CCL11, IL5, IL13
17fluticasone propionate45 50 60 1114.5RNASE3, IL5, IL13, IGHE, CCL11
18pgd24511.5IL5, IL13, RNASE3, IGHE, CCL11
19leukotriene b445 60 2413.4CCL22, CCL11, RNASE3, IL13, IL5
20unicap4511.4RNASE3, CCL11, IL5, IGHE
21prednisolone45 29 1113.4IL13, IGHE, CCL11, RNASE3, IL5
22anti-histamine4511.4HRH1, RNASE3, CCL11, IGHE
23nedocromil sodium4511.4RNASE3, IGHE, IL5, HRH1
24praziquantel45 1112.4IL5, IGHE, RNASE3, IL13
25salmeterol45 50 29 1114.4RNASE3, IL13, IL5, CCL11
26azelastine45 1112.4IL5, HRH1, IGHE, RNASE3
27ltd44511.3HRH1, IL5, IL13, RNASE3
28ltc44511.3RNASE3, CCL11, IL13, IL5
29rantes4511.3HRH1, CCL11, RNASE3
30clemastine fumarate6011.2HRH1, DHX8, DHX34
31mepyramine maleate6011.2DHX8, DHX34, HRH1
32histamine dihydrochloride6011.2DHX8, DHX34, HRH1
332-pyridylethylamine dihydrochloride6011.2DHX8, DHX34, HRH1
34omalizumab45 1112.2IGHE, IL13, IL5
35oxatomide4511.2IGHE, IL5, HRH1
36levocabastine45 29 1113.2HRH1, IL5, RNASE3
37beclomethasone dipropionate4511.1RNASE3, IGHE, IL5
38ovomucoid4511.1IL5, IL13, IGHE
39toluene diisocyanate4511.1RNASE3, IL5, IGHE
40lte44511.1RNASE3, CCL11, IL5
41capsaicin45 2912.1HRH1, IGHE, RNASE3, IL5
42astemizole45 60 29 1114.1DHX34, DHX8, HRH1
43desloratadine45 1112.1IL13, IGHE, HRH1
44olopatadine45 1112.0IGHE, CCL17, HRH1
45aspirin45 50 29 2414.0IL13, RNASE3, CCL11, HRH1, CCL22
46roxithromycin45 29 1113.0CCL17, CCL11, IL5
47loratadine45 11 2412.9HRH1, RNASE3, IGHE
48pranlukast45 29 1112.9CCL11, RNASE3, IL5
49larc4510.9CCL22, CCL18, CCL17
50penicillin4510.6IL5, IGHE, IL13

GO Terms for genes affiliated with Atopic Dermatitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557611.6CCL22, CCL11, CCL17, CCL27, IGHE, RNASE3
2extracellular spaceGO:00561511.3TSLP, CCL22, CCL11, CCL18, CCL17, CCL27

Biological processes related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1immune responseGO:00695511.5IL5, CCL22, CCL11, CCL18, CCL17, CCL27
2inflammatory responseGO:00695411.4CCL22, CCL11, CCL18, CCL17, IL13, IL5
3chemotaxisGO:00693511.0CCL22, CCL11, CCL18, CCL17, CCL27
4cell-cell signalingGO:00726710.8IL13, CCL27, CCL17, CCL18, CCL22
5eosinophil chemotaxisGO:04824510.7HRH1, CCL11

Molecular functions related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512511.0TSLP, IL5, IL31, IL13
2chemokine activityGO:00800910.8CCL27, CCL17, CCL18, CCL11, CCL22

Products for genes affiliated with Atopic Dermatitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopic Dermatitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet