MCID: ATP001
MIFTS: 67

Atopic Dermatitis malady

Skin diseases, Neuronal diseases, Immune diseases categories
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Summaries for Atopic Dermatitis

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Disease Ontology:8 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

MalaCards based summary: Atopic Dermatitis, also known as allergic dermatitis, is related to eczema herpeticum and food allergy. An important gene associated with Atopic Dermatitis is KLK7 (kallikrein-related peptidase 7), and among its related pathways are IL4-mediated signaling events and Peptide ligand-binding receptors. The drugs betamethasone and betamethasone acetate and the compounds levocetirizine and roxithromycin have been mentioned in the context of this disorder. Affiliated tissues include the skin, skin and t cells.

Wikipedia:65 Atopic dermatitis (AD) also known as atopic eczema or eczema is a type of dermatitis, an inflammatory,... more...

Description from OMIM:46 603165

Aliases & Classifications for Atopic Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 44Novoseek, 62UMLS, 46OMIM, 57SNOMED-CT, 27ICD9CM, 34MeSH, 25ICD10
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Atopic Dermatitis, Aliases & Descriptions:

Name: Atopic Dermatitis 8 10
Allergic Dermatitis 8 62
Besnier's Prurigo 8 62
Neurodermatitis, Atopic 62
Atopic Neurodermatitis 8
Atopic Dermatitis Nos 8
 
Dermatitis, Atopic 62
Allergic Eczema 8
Dermatitis Atopic 44
Eczema, Atopic 62
Atopic Eczema 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Neuronal diseases, Immune diseases


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Disease Ontology8 DOID:3310
OMIM46 603165
ICD9CM27 691.8
MeSH34 D003876
ICD1025 L20, L20.0

Related Diseases for Atopic Dermatitis

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Diseases in the Atopic Dermatitis family:

Dermatitis, Atopic 2 Dermatitis, Atopic 1
Dermatitis, Atopic 6 Dermatitis, Atopic 7
Dermatitis, Atopic 5 Dermatitis, Atopic 4
Dermatitis, Atopic 3

Diseases related to Atopic Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 218)
idRelated DiseaseScoreTop Affiliating Genes
1eczema herpeticum31.7IGHE
2food allergy31.6IGHE, CCL11
3contact dermatitis31.5FLG, IGHE
4dermatitis31.5IL31, IGHE, FLG, CCL17, CCL18, CCL22
5keratoconjunctivitis31.4CCL11
6allergic contact dermatitis31.3CCL27, FLG
7rhinitis31.2IGHE, CCL11, HRH1
8conjunctivitis31.1HRH1, IGHE
9asthma31.1IGHE, FLG, CCL17, CCL22, CCL11, HRH1
10netherton syndrome31.0IGHE, KLK7
11atopy31.0IGHE, FLG, CCL17, CCL22, CCL11
12allergic rhinitis30.9IGHE, CCL11, HRH1
13eosinophilia30.9CCL27, CCL11, CCL17, IGHE
14bronchitis30.8IGHE, CCL11
15eosinophilic gastroenteritis30.8CCL11, IGHE
16malaria30.7HRH1
17vernal keratoconjunctivitis30.6IGHE, CCL11
18allergic asthma30.6IGHE, FLG, CCL17, CCL11, HRH1
19psoriasis30.6FLG, CCL17, CCL18, CCL22, CCL11, CCL27
20allergic conjunctivitis30.6IGHE, CCL11, HRH1
21bullous pemphigoid30.3IGHE, FLG, CCL17, CCL11
22rheumatoid arthritis30.2FLG, CCL18, CCL11, CCL27, HRH1
23mycosis fungoides30.2CCL17, CCL22, CCL27
24skin disease30.0IGHE, HRH1, KLK7, IL31, CCL27, CCL11
25pneumonia29.9HRH1, CCL11, CCL22, CCL18, CCL17
26ichthyosis vulgaris10.7
27blindness10.7
28impetigo10.5
29urticaria10.5
30alopecia10.5
31egg allergy10.5
32vaccinia10.5
33alopecia areata10.5
34cutaneous t cell lymphoma10.5
35hyper ige syndrome10.5
36strongyloidiasis10.5IGHE
37skin conditions10.4
38lichen planus10.4
39molluscum contagiosum10.4
40neurodermatitis10.4
41chronic actinic dermatitis10.4
42arthritis10.4
43vitiligo10.4
44endotheliitis10.4
45nonepidermolytic palmoplantar keratoderma10.4FLG, KLK7
46pulmonary eosinophilia10.4CCL11, IGHE
47hypereosinophilic syndrome10.3IGHE, CCL11
48pemphigus vulgaris10.3CCL17, CCL11
49otitis media10.3CCL11, IGHE
50acne10.3

Graphical network of the top 20 diseases related to Atopic Dermatitis:



Diseases related to atopic dermatitis

Symptoms for Atopic Dermatitis

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Clinical features from OMIM:

603165

Drugs & Therapeutics for Atopic Dermatitis

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Genetic Tests for Atopic Dermatitis

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Anatomical Context for Atopic Dermatitis

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MalaCards organs/tissues related to Atopic Dermatitis:

32
Skin, T cells, Testes, Monocytes, Colon, Thymus, B cells, Breast, Endothelial, Neutrophil, Whole blood, Bone, Liver, Kidney, Thyroid, Tonsil, Myeloid

FMA organs/tissues related to Atopic Dermatitis:

14
The skin

Animal Models for Atopic Dermatitis or affiliated genes

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Publications for Atopic Dermatitis

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Articles related to Atopic Dermatitis:

(show top 50)    (show all 1715)
idTitleAuthorsYear
1
Human I^-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis. (23647067)
2013
2
Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model. (23149290)
2013
3
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
4
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. (23918359)
2013
5
Difficult to control atopic dermatitis. (23663504)
2013
6
Evaluation of food allergy in patients with atopic dermatitis. (24229818)
2013
7
Treatment of the chronic itch of atopic dermatitis using standard drugs and kampo medicines. (23902969)
2013
8
Comparison of the psychological impacts of asymptomatic and symptomatic cutaneous diseases: vitiligo and atopic dermatitis. (24371393)
2013
9
Effect of bathing on atopic dermatitis during the summer season. (23130333)
2012
10
Impact of interactive web-based education with mobile and email-based support of general practitioners on treatment and referral patterns of patients with atopic dermatitis: randomized controlled trial. (23249479)
2012
11
Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. (23166590)
2012
12
Inflammation-driven dermal lymphangiogenesis in atopic dermatitis is associated with CD11b+ macrophage recruitment and VEGF-C up-regulation in the IL-4-transgenic mouse model. (22574929)
2012
13
Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and Psoriasis. (23193414)
2012
14
Role of food allergy in childhood atopic dermatitis. (21679336)
2012
15
Kaposi's sarcoma in an atopic dermatitis patient: a case report and a review of literature. (21385206)
2011
16
Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis. (21039602)
2011
17
Atopic dermatitis - current insights into path physiology and management]. (20336617)
2010
18
Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis. (19874431)
2010
19
CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy. (19758316)
2010
20
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. (19818482)
2010
21
Association of single nucleotide polymorphism of interleukin-18 with atopic dermatitis. (19453784)
2010
22
Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis. (19767072)
2009
23
Our evolving understanding of the functional role of filaggrin in atopic dermatitis. (19733296)
2009
24
Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. (18538383)
2008
25
Staphylococcus aureus skin colonization in atopic dermatitis children is associated with decreased IFN-gamma production by peripheral blood CD4+ and CD8+ T cells. (17662038)
2008
26
Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. (19052401)
2008
27
The effect of wet-wrap dressing on epidermal barrier in patients with atopic dermatitis. (17958842)
2007
28
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis. (17579279)
2007
29
Ingestion of heat-treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice. (17250703)
2007
30
Analysis of components of the CD14/TLR system on leukocytes of patients with atopic dermatitis. (17284926)
2007
31
Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study]. (17405298)
2006
32
Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis. (16536804)
2006
33
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. (15944307)
2005
34
Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. (15491080)
2004
35
Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis. (12635580)
2003
36
Flow cytometric analysis of IL-4, IL-13 and IFN-gamma expression in peripheral blood mononuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the disease. (12007717)
2002
37
Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis. (12406333)
2002
38
Etiologic implication of foods in atopic dermatitis: evidence in favor]. (11988141)
2002
39
Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia. (11480592)
2001
40
Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. (10856157)
2000
41
Soluble E-selectin correlates with disease activity in cyclosporin A-treated patients with atopic dermatitis. (10195358)
1999
42
Acute inflammatory demyelinating polyradiculoneuropathy associated with hyperIgEemia and atopic dermatitis. (9562273)
1998
43
Long-term therapy with recombinant interferon-gamma (rIFN-gamma) for atopic dermatitis. (9532976)
1998
44
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis. (9028795)
1996
45
RANTES mRNA expression in skin and colon of patients with atopic dermatitis. (8906106)
1996
46
Corticosteroid-induced apoptosis of eosinophils in atopic dermatitis patients. (10036642)
1996
47
Systemic interferon gamma treatment in severe atopic dermatitis. (8315079)
1993
48
Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis. (1575548)
1992
49
Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis. (1721013)
1991
50
Atopic dermatitis and Ritter's disease: differential diagnosis by means of total and specific serum IgE. (147160)
1978

Variations for Atopic Dermatitis

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Expression for genes affiliated with Atopic Dermatitis

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Expression patterns in normal tissues for genes affiliated with Atopic Dermatitis

Search GEO for disease gene expression data for Atopic Dermatitis.

Pathways for genes affiliated with Atopic Dermatitis

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Pathways related to Atopic Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCL11, CCL17, IGHE
2
Show member pathways
9.1CCL17, CCL11, CCL27, HRH1, CCL22
3
Show member pathways
8.8CCL27, CCL17, CCL18, CCL22, CCL11
4
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
5
Show member pathways
8.8CCL11, CCL17, CCL18, CCL22, CCL27
6
Show member pathways
8.8CCL27, CCL18, CCL17, CCL22, CCL11
7
Show member pathways
8.8CCL11, CCL22, CCL18, CCL17, CCL27
8
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
9
Show member pathways
8.8CCL11, CCL27, CCL18, CCL17, CCL22
10
Show member pathways
8.5NACA, CCL18, CCL27, CCL11, CCL22, CCL17

Compounds for genes affiliated with Atopic Dermatitis

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Compounds related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1levocetirizine4410.4CCL11, HRH1
2roxithromycin44 28 1112.4CCL11, CCL17
3unicap4410.2CCL11, IGHE
42-pyridylethylamine dihydrochloride6110.2HRH1, DHX34, DHX8
5histamine dihydrochloride6110.2HRH1, DHX8, DHX34
6mepyramine maleate6110.2HRH1, DHX34, DHX8
7clemastine fumarate6110.1DHX34, DHX8, HRH1
8astemizole44 61 28 1113.1HRH1, DHX8, DHX34
9oxatomide4410.1IGHE, HRH1
10desloratadine44 1111.1HRH1, IGHE
11nedocromil sodium4410.1HRH1, IGHE
12loratadine44 24 1112.0HRH1, IGHE
13anti-histamine4410.0HRH1, IGHE, CCL11
14sodium cromoglycate4410.0IGHE, HRH1, CCL11
15pertussis4410.0CCL11, CCL22, IGHE
16cetirizine44 28 24 1113.0CCL11, HRH1, IGHE
17montelukast44 50 28 1113.0IGHE, CCL11
18methacholine44 50 1112.0IGHE, CCL22, CCL11
19ketotifen44 1111.0HRH1, IGHE, CCL11
20olopatadine44 1111.0HRH1, CCL17, IGHE
21tacrolimus44 50 1112.0CCL11, CCL22, HRH1, CCL17
22azelastine44 1111.0HRH1, IGHE
23prostaglandin449.9CCL22, CCL11, HRH1
24fluticasone propionate44 50 61 1112.9CCL11, IGHE
25aspirin44 50 28 2412.8HRH1, CCL11, CCL22
26larc449.8CCL22, CCL18, CCL17
27budesonide44 50 1111.8CCL11, IGHE
28salbutamol44 50 28 24 1113.6IGHE, CCL11
29cyclosporin a44 28 6111.6IGHE, CCL17, CCL22, HRH1, CCL11
30pge2449.5CCL22, CCL27, CCL11, HRH1
31histamine44 28 2411.4IL31, HRH1, CCL22, IGHE, CCL11
32ccl344 2810.2CCL18, CCL22, CCL11, CCL27, CCL17
33ccl444 2810.2CCL17, CCL27, CCL11, CCL22, CCL18
34allergens449.2CCL17, FLG, CCL11, IGHE, HRH1, CCL27
35rantes448.9CCL27, CCL17, CCL22, HRH1, CCL18, CCL11
36tarc448.8CCL27, CCL22, CCL18, CCL17, IGHE, CCL11
37alanine448.7CCL27, CCL18, IGHE, HRH1, CCL11
38dexamethasone44 50 28 1111.5CCL22, CCL11, HRH1, CCL18, CCL17, IGHE
39calcium44 50 24 1111.4HRH1, CCL11, CCL22, CCL18, CCL17, FLG

GO Terms for genes affiliated with Atopic Dermatitis

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Cellular components related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8IGHE, CCL17, CCL22, CCL11, CCL27, KLK7
2extracellular spaceGO:0056158.1CCL17, CCL18, CCL22, CCL11, CCL27, IL31

Biological processes related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0HRH1, CCL11
2cell chemotaxisGO:0603269.0CCL18, CCL22, CCL27, CCL17
3inflammatory responseGO:0069548.9HRH1, CCL11, CCL22, CCL17, CCL18
4chemotaxisGO:0069358.9CCL27, CCL11, CCL22, CCL18, CCL17
5cell-cell signalingGO:0072678.6CCL18, CCL17, CCL27, CCL22
6immune responseGO:0069558.3CCL18, CCL27, CCL11, CCL22, CCL17, IGHE

Molecular functions related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080098.8CCL27, CCL11, CCL22, CCL18, CCL17

Products for genes affiliated with Atopic Dermatitis

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Sources for Atopic Dermatitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet