Atopic Dermatitis malady

Disease Ontology: A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.⁶

MalaCards: Atopic Dermatitis, also known as besnier's prurigo, is related to dermatitis and psoriasis. An important gene associated with Atopic Dermatitis is FAF2 (Fas associated factor family member 2), and among its related pathways are STAT3 Pathway and Akt Signaling. The drugs alclometasone dipropionate and alclometasone and the compounds calcium and allergens have been mentioned in the context of this disorder. Affiliated tissues include the skin, whole blood and thymus, and related mouse phenotypes are hematopoietic system and integument.

Wikipedia: Atopic dermatitis (AD, a type of eczema) is an inflammatory, chronically relapsing, non-contagious and...⁴⁴ more...

Aliases & Descriptions:

atopic dermatitis 6 8 besnier's prurigo 6 43 allergic (intrinsic) eczema (disorder) 6 atopic neurodermatitis (disorder) 6 atopic dermatitis nos (disorder) 6 atopic dermatitis (disorder) 6

besnier's prurigo (disorder) 6 allergic dermatitis 6 dermatitis, atopic 43 dermatitis atopic 32 dermatitis 43

Disease types for atopic dermatitis family:

dermatitis, atopic 1	dermatitis, atopic 7
dermatitis, atopic 6	dermatitis, atopic 3
dermatitis, atopic 5	dermatitis, atopic 2

Diseases related to atopic dermatitis by text searches and GeneDecks gene sharing:

(show top 50)    (show all 1014)

id	Related Disease	Score	Top Affiliating Genes
1	dermatitis	64.0	PI3, PDE3B, PDE4A, REL, RELA, RELB
2	psoriasis	42.0	PI3, PDE4A, KITLG, SFTPD, SELE, SELP
3	eczema	41.8	SELE, VIP, CMA1, LGALS3, LCE3B, LCE3C
4	atopy	40.4	RELA, KITLG, SELP, NAT2, VEGFA, CMA1
5	carcinoma	38.8	PI3, PDE3B, PDE4A, REL, RELA, RELB
6	eosinophilia	37.4	PDE3B, PDE4A, SFTPD, SELL, VDAC2, VCAM1
7	asthma	37.3	IL12B, IL13, CCL11, HNMT, HLA-G, TNF
8	allergic asthma	37.0	PDE3B, SERPINB3, SERPINB4, VCAM1, BDNF, BCL2
9	dermatitis herpetiformis	36.4	SELE, CD79A, CD40LG, ITGAM, IL13, IL2RA
10	ichthyosis	36.0	RELA, CLDN1, LBR, KAL1, IVL, FLG
11	skin disease	35.4	PI3, PDE4A, SFTPD, SELE, SELL, SELP
12	rhinitis	35.3	PDE4A, RELA, KITLG, SFTPD, SELE, SELL
13	contact dermatitis	35.2	FLG, IL1A, IL5, CCR4, IGHE, CXCL9
14	eczema herpeticum	34.4	CDSN, FLG2, FLG, IL7R, IGHE, CAMP
15	leukemia	33.8	PDE3B, PDE4A, REL, RELA, RELB, KITLG
16	vaccinia	33.3	RELA, KITLG, CIITA, MUC1, S100B, JUN
17	immunodeficiency	33.0	SELL, VIP, CIITA, CD79A, CD69, CD40LG
18	mycosis fungoides	32.9	CNFN, SELE, SELP, VCAM1, BCL2, S100A8
19	food allergy	32.7	S100A8, FOXP3, IL13, IL4, IL5, CCL11
20	arthritis	32.7	SELL, VIP, IL17A, IL1A, IL1B, IL6
21	allergic rhinitis	32.5	MPO, FCER2, IL13, IL18, IL4, IL4R
22	diaper rash	32.4	VNN3, LCE3A, LCE5A, FLG2, IL1A, LOR
23	netherton syndrome	32.2	PI3, CDSN, FLG, IGHE, SPINK5, SPINK9
24	tonsillitis	32.0	VIM, VEGFA, CMA1, BDNF, BCL2, MUC1
25	alopecia areata	32.0	CIITA, CD79A, CD40, GZMB, FLG, MIF
26	rheumatoid arthritis	32.0	CIITA, CD40, MIF, IL10, IL1B, IL1RN
27	allergic contact dermatitis of eyelid	31.9	SELE, NAT2, FLG, IL17A, IL4R, IL5
28	chronic obstructive pulmonary disease	31.9	PI3, PDE4A, SFTPD, NAT2, MPO, CD80
29	bronchial asthma	31.7	PDE3B, KITLG, SFTPD, SELE, SELL, SELP
30	hyper-ige syndrome	31.5	SELL, MMP9, IL10, IL13, IL17A, IL4
31	urticaria	31.4	KITLG, SELE, SELP, VEGFA, VCAM1, CMA1
32	skin conditions	30.8	IL1A, IL6, IGHE, IFNK, TNF, KRT10
33	bronchitis	30.7	PDE4A, SELL, LEP, IL17A, MBL2, ALOX5
34	folliculitis	30.7	NACA, FCGR3A, IL2RA, IL4, IL5, CCL11
35	toxic shock syndrome	30.6	CIITA, LBR, CD69, CD40LG, FCER2, IL10
36	squamous cell carcinoma	30.5	PI3, RELA, SELL, SERPINB3, SERPINB4, VIM
37	alopecia	30.4	KITLG, CLDN1, CIITA, MUC1, CD79A, CD40
38	pulmonary disease	30.3	PI3, PDE4A, SFTPD, SELE, SELL, SELP
39	blau syndrome	30.2	IL10, IL1B, IL1RAPL2, TNF, NOD1, NOD2
40	measles	30.0	RELA, SFTPD, SELE, VCAM1, CIITA, LBR
41	onchocerciasis	29.9	LBR, S100A8, IL10, IL13, IL4, IL5
42	bullous pemphigoid	29.8	CIITA, CD79A, IVL, ITGA6, FLG, FCER2
43	cutaneous t cell lymphoma	29.6	SELE, SELL, GZMB, IL15, IL2, IL2RA
44	fibrosis	29.4	PI3, PDE4A, RELA, KITLG, SFTPD, SELE
45	herpes simplex	29.4	VIM, VEGFA, CLDN1, BGLAP, BDNF, BCL2
46	psoriatic arthritis	28.9	SELE, IL13, IL1A, IL1B, IL1RAPL2, HLA-DRB1
47	celiac disease	28.7	CIITA, MIF, IL6, HLA-DQA1, HLA-DQB1, HLA-DRB1
48	sinusitis	28.6	PI3, RELA, SFTPD, SELL, SELP, SERPINB3
49	adenoiditis	28.5	RELA, SERPINB3, SERPINB4, VIM, VEGFA, VCAM1
50	graft versus host disease	28.3	SELL, GZMB, IL10, IL13, IL15, IL18

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 alclometasone, alclometasone dipropionate, amcinonide, betamethasone, betamethasone acetate, betamethasone benzoate, betamethasone dipropionate, betamethasone sodium phosphate, betamethasone valerate, betamethasone valerate pwdr [va product], clobetasol, clobetasol propionate, cod liver oil [va product], doxepin, doxepin hydrochloride, fluocinolone, fluocinolone acetonide, methdilazine, methdilazine hydrochloride, pimecrolimus, racemethionine, tacrolimus, trimeprazine, trimeprazine tartrate, triprolidine, triprolidine hydrochloride, vitamin a, vitamin a (as acetate & beta carotene), vitamin a (as acetate), vitamin a (as palmitate & beta carotene), vitamin a (natural), vitamin a acetate, vitamin a palmitate, vitamin a palmitate (solubilized), zinc (as zinc oxide)

MalaCards organs/tissues related to atopic dermatitis:

²²

FMA organs/tissues related to atopic dermatitis:

¹¹

MGI Mouse Phenotypes related to atopic dermatitis:

²⁵ (show all 23)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	15.5	SGPL1, BCL11B, BCL2, LGALS3, SATB1, FUT4
2	integument phenotype	MP:0010771	13.3	PDE3B, REL, RELA, RELB, KITLG, SELP
3	mortality/aging	MP:0010768	13.2	REL, RELA, RELB, SGPL1, KITLG, SFTPD
4	immune system phenotype	MP:0005387	13.1	PDE4A, REL, RELB, SGPL1, SELL, SELP
5	growth/size phenotype	MP:0005378	12.6	PDE3B, REL, RELA, RELB, SGPL1, KITLG
6	respiratory system phenotype	MP:0005388	12.1	REL, RELB, SGPL1, SFTPD, SELL, SELP
7	endocrine/exocrine gland phenotype	MP:0005379	11.7	RELB, SGPL1, SELL, LALBA, CDSN, CD40LG
8	normal phenotype	MP:0002873	11.4	RELA, SELE, VIP, VEGFA, BDNF, CIITA
9	cellular phenotype	MP:0005384	11.2	REL, RELA, RELB, SGPL1, KITLG, SELE
10	renal/urinary system phenotype	MP:0005367	10.5	SGPL1, SELP, BCL2, LGMN, AVP, CD180
11	homeostasis/metabolism phenotype	MP:0005376	10.4	PDE3B, REL, RELA, RELB, SGPL1, KITLG
12	nervous system phenotype	MP:0003631	10.4	PDE4A, REL, RELA, KITLG, SELP, BDNF
13	behavior/neurological phenotype	MP:0005386	10.2	RELB, SELE, SELP, SEMA3A, VIM, VIP
14	no phenotypic analysis	MP:0003012	10.1	SEMA3A, VEGFA, VCAM1, BDNF, BCL11B, MUC1
15	digestive/alimentary phenotype	MP:0005381	10.0	REL, RELB, SGPL1, KITLG, VEGFA, BDNF
16	liver/biliary system phenotype	MP:0005370	9.9	REL, RELB, VEGFA, LGMN, CD36, IL12RB2
17	reproductive system phenotype	MP:0005389	9.7	SGPL1, VIP, VEGFA, CLIC4, LEP, LALBA
18	tumorigenesis	MP:0002006	9.1	KITLG, SELL, BCL11B, BCL2, LEP, MUC1
19	skeleton phenotype	MP:0005390	9.1	REL, RELA, SGPL1, KITLG, SEMA3A, NACA
20	adipose tissue phenotype	MP:0005375	8.4	PDE3B, BCL2, LEP, LBR, CD36, CD14
21	cardiovascular system phenotype	MP:0005385	8.3	PDE4A, REL, RELA, RELB, SGPL1, KITLG
22	vision/eye phenotype	MP:0005391	7.7	RELA, KITLG, SELE, SELP, VIM, VEGFA
23	muscle phenotype	MP:0005369	7.2	RELA, RELB, SGPL1, VIM, NACA, VEGFA

Articles related to atopic dermatitis:

(show top 50)    (show all 910)

id	Title	Authors	Year	Affiliating Genes
1	Kinetics and differential expression of the skin-rela ted chemokines CCL27 and CCL17 in psoriasis, atopic dermatitis and allergic con tact dermatitis. (21707761)	Riis J.L.... Iversen L.	2011	CCL17, CCL27
2	Genetic variations in MyD88 adaptor-like are associat ed with atopic dermatitis. (21399862)	An Y.... Kondo N.	2011	TIRAP
3	Atopic dermatitis - current insights into path physi ology and management (20336617)	Schmid-Grendelmeier P.... Ballmer-Weber B.K.	2010	FLG
4	Sustained exogenous expression of therapeutic levels of IFN-gamma ameliorates atopic dermatitis in NC/Nga mice via Th1 polarization. (20107184)	Hattori K.... Takakura Y.	2010	IFNG
5	Quantitative analysis of nerve growth factor (NGF) in the atopic dermatitis and psoriasis horny layer and effect of treatment on NGF in atopic dermatitis. (18922683)	Yamaguchi J.... Ikezawa Z.	2009	NGF
6	Cellular and molecular mechanisms in atopic dermatiti s. (19477321)	Oyoshi M.K.... Geha R.S.	2009	TSLP
7	Serum measurement of thymus and activation-regulated chemokine/CCL17 in children with atopic dermatitis: elevated normal levels in i nfancy and age-specific analysis in atopic dermatitis. (19236603)	Fujisawa T.... Tamaki K.	2009	CCL17
8	Expression of HSP60, TLR4 and NF-kappaBp65 in the pe ripheral blood of patients with atopic dermatitis (19764566)	Gao Y.... Guo Z.P.	2009	RELA, TLR4, HSPD1
9	Efficacy of omalizumab in the treatment of atopic dermatitis: a pilot study. (18926061)	Sheinkopf L.E.... Klaustermeyer W.B.	2008	IGHE
10	Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials. (18284263)	Betsi G.I.... Falagas M.E.	2008	IL4, IFNG, RNASE3
11	Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). (18693163)	Fukiwake N.... Furue M.	2008	IGHE
12	Unnecessary milk elimination diets in children with atopic dermatitis. (17300640)	Sinagra J.L.... Capitanio B.	2007	LALBA, CSN1S1
13	Filaggrin mutations in children with severe atopic dermatitis. (17301831)	Morar N.... Moffatt M.F.	2007	FLG
14	Association of toll-interacting protein gene polymorphisms with atopic dermatitis. (17362526)	Schimming T.T.... Hoffjan S.	2007	TOLLIP
15	Topical application of a novel ceramide derivative, K6PC-9, inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. (17996668)	Kang J.S.... Kim H.M.	2007	SELE
16	The genetics of atopic dermatitis. (18163224)	Chien Y.H.... Chiang B.L.	2007	CMA1, IL13, IL4R
17	Thymus and activation regulated chemokines in children with atopic dermatitis: Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). (17673383)	Furusyo N.... Hayashi J.	2007	CCL17
18	Expression pattern of somatostatin receptor subtypes 1-5 in human skin: an immunohistochemical study of healthy subjects and patient s with psoriasis or atopic dermatitis. (17083361)	HagstrAPmer L.... Talme T.	2006	SSTR5
19	The objective severity assessment of atopic dermatitis (OSAAD) score: validity, reliability and sensitivity in adult patients with atopic dermatitis. (16181458)	Angelova-Fischer I.... Fluhr J.W.	2005	IL16
20	Tacrolimus decreases the expression of eotaxin, CCR3, RANTES and interleukin-5 in atopic dermatitis. (15948978)	Park C.W.... Ahn H.K.	2005	CCR3, CCL11, CCL5
21	Natural history of atopic dermatitis and its relationship to serum total immunoglobulin E in a population-based birth cohort study. (15209954)	Perkin M.R.... Golding J.	2004	IGHE
22	Serum concentration of IL-18 correlates with disease extent in young children with atopic dermatitis. (15575842)	Hon K.L.... Lam C.W.	2004	IL18
23	Serum levels of cutaneous T-cell attracting chemokine (CTACK) as a laboratory marker of the severity of atopic dermatitis in children. (15115514)	Hon K.L.... Fok T.F.	2004	CCL22, CCL27
24	T cell epitope-specific defects in the immune response to cat allergen in patients with atopic dermatitis. (15102083)	Carneiro R.... Woodfolk J.	2004	IFNG
25	Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis and in vitro cytokine-stimulated blood eosinophils. (12605696)	Ogawa K.... Saito H.	2003	CSF2RA
26	Epinastine inhibits eosinophil chemotaxis and adhesio n molecules in atopic dermatitis. (14528065)	Matsukura M.... Tezuka T.	2003	IL5
27	Cytokine gene polymorphisms in atopic dermatitis. (12828754)	Reich K.... Neumann C.	2003	TNF, IL6, IL1B
28	The interleukin-13 production by peripheral blood T cells from atopic dermatitis patients does not require CD2 costimulation. (14600427)	Simon D.... Simon H.U.	2003	IL13
29	Characterization of chemokine receptor expression and cytokine production in circulating CD4+ T cells from patients with atopic dermatitis: up-regulation of C-C chemokine receptor 4 in atopic dermatitis. (12190665)	Okazaki H.... Minota S.	2002	CCR3, CXCR3, CCR4
30	Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis. (12406333)	Novak N.... Bieber T.	2002	IL13, IGHE
31	Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are not associated with susceptibility to atopic dermatitis, but two of them in the promoter region are associated with serum IgE levels in patients with atopic dermatitis. (12234713)	Tsunemi Y.... Tamaki K.	2002	CCL11
32	Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: association between IL-13 and mite-specific IgE levels. (11164708)	Wakugawa M.... Tamaki K.	2001	IL13
33	Expression of IL-18 mRNA and secretion of IL-18 are reduced in monocytes from patients with atopic dermatitis. (11590389)	Higashi N.... Thestrup-Pedersen K.	2001	CASP1, IL18
34	Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. (11240957)	Kakinuma T.... Tamaki K.	2001	CCR4, CCL17
35	Interleukin-18 is elevated in the sera from patients with atopic dermatitis and from atopic dermatitis model mice, NC/Nga. (11490156)	Tanaka T.... Suemura M.	2001	IL18
36	Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. (10856157)	Ochs R.L.... Tan E.M.	2000	PSIP1
37	Comparison of severity scoring of atopic dermatitis values and serum levels of eosinophil cationic protein and mast cell tryptase for routine evaluation of atopic dermatitis. (11028863)	Amon U.... Amon S.	2000	RNASE3
38	Latex type I sensitization and allergy in children with atopic dermatitis. Evaluation of cross-reactivity to some foods. (10565556)	TA1cke J.... Raulf-Heimsoth M.	1999	IGHE
39	Modulation of cutaneous SP receptors in atopic dermatitis after UVA irradiation. (9534883)	Staniek V.... Misery L.	1998	TACR1
40	Monitoring of disease activity by measurement of inflammatory markers in atopic dermatitis in childhood. (9265994)	Halmerbauer G.... Koller D.Y.	1997	ICAM1, IL2RA, SELE
41	Circulating skin-homing T cells in atopic dermatitis. Selective up-regulation of HLA-DR, interleukin-2R, and CD30 and decrease after combined UV-A and UV-B phototherapy. (8859027)	Piletta P.A.... Hauser C.	1996	IL2RA
42	Eosinophil chemiluminescence response to cytokines and opsonized zymosans in atopic dermatitis. (8155999)	Miyasato M.... Kato K.	1994	RNASE3
43	E-selectin and vascular cell adhesion molecule-1 as critical adhesion molecules for infiltration of T lymphocytes and eosinophils in atopic dermatitis. (7514618)	Wakita H.... Takigawa M.	1994	SELE
44	Measurement of interferon gamma (gamma IFN) and interleukin 4 (IL4) in asthma and atopic dermatitis (8155271)	Sabbah A.... Lauret M.G.	1993	IFNG
45	Fc epsilon receptor II/CD23+ lymphocytes in atopic dermatitis. III. Aberrant control in the in vitro expression of Fc epsilon RII/CD23 on peripheral blood T cells in atopic dermatitis. (1531123)	Sakamoto T.... Takigawa M.	1992	IL4, IFNG, FCER2
46	High-dose UVA1 therapy in the treatment of patients with atopic dermatitis. (1552057)	Krutmann J.... SchAPpf E.	1992	RNASE3
47	Staphylococcus aureus modifies the cytokine-induced immunoglobulin synthesis and CD23 expression in patients with atopic dermatitis. (1830026)	Neuber K.... KAPnig W.	1991	FCER2
48	Levels of soluble interleukin-2 receptors correlate with the severity of atopic dermatitis. (2242792)	WA1thrich B.... Grob P.J.	1990	IL2RA
49	Fc epsilon receptor II/CD23 positive lymphocytes in atopic dermatitis: II. Infiltration of Fc epsilon R II(+) T cells in the skin lesion. (2146324)	Sakamoto T.... Yamada M.	1990	IGHE
50	Serum IgE and Fc epsilon receptor positive lymphocytes in atopic dermatitis--relation to the background of respiratory atopy (2142510)	Higaki Y.	1990	IGHE

Genes related to atopic dermatitis according to GeneCards:

(show top 50)    (show all 411)

id	Symbol	Description	Score	GeneCards Section Context
1	FAF2	Fas associated factor family member 2	11.1	Publications, Aliases & Descriptions, UniProt Related, Summaries
2	CCL11	chemokine (C-C motif) ligand 11	11.1	Summaries, Publications
3	KLK7	kallikrein-related peptidase 7	11.1	Publications, Summaries
4	NACA	nascent polypeptide-associated complex alpha subunit	11.1	Publications, Summaries
5	COL6A5	collagen, type VI, alpha 5	11.1	Summaries, Publications
6	DHX34	DEAH (Asp-Glu-Ala-His) box polypeptide 34	11.1	Summaries
7	HRH1	histamine receptor H1	11.1	Summaries
8	ATOD5	Dermatitis, atopic, 5	11.0	Publications
9	ATOD6	Dermatitis, atopic, 6	11.0	Publications
10	ATOD3	Dermatitis, atopic, 3	11.0	Publications
11	ATOD	Dermatitis, atopic	11.0	Publications
12	ST2	suppression of tumorigenicity 2	11.0	Publications
13	IL31	interleukin 31	11.0	Functions, Publications
14	CCL17	chemokine (C-C motif) ligand 17	11.0	Publications
15	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
16	FLG	filaggrin	11.0	Publications
17	LCE5A	late cornified envelope 5A	11.0	Publications
18	CCL22	chemokine (C-C motif) ligand 22	11.0	Publications, Expressions
19	CCL27	chemokine (C-C motif) ligand 27	11.0	Publications
20	CCL18	chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)	11.0	Publications
21	CCR4	chemokine (C-C motif) receptor 4	11.0	Publications
22	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
23	CNFN	cornifelin	11.0	Expressions
24	TSLP	thymic stromal lymphopoietin	11.0	Publications
25	LCE3B	late cornified envelope 3B	11.0	Publications
26	LCE3A	late cornified envelope 3A	11.0	Publications
27	RNASE7	ribonuclease, RNase A family, 7	11.0	Publications
28	CRLF2	cytokine receptor-like factor 2	11.0	Publications
29	SPINK9	serine peptidase inhibitor, Kazal type 9	11.0
30	DEFA4	defensin, alpha 4, corticostatin	11.0	Publications
31	DEFA6	defensin, alpha 6, Paneth cell-specific	11.0	Publications
32	DCD	dermcidin	11.0	Publications
33	NAT9	N-acetyltransferase 9 (GCN5-related, putative)	11.0	Publications
34	FLG2	filaggrin family member 2	11.0	Publications
35	CST6	cystatin E/M	11.0	Publications
36	LCE3C	late cornified envelope 3C	11.0	Publications
37	IGES	immunoglobulin E concentration, serum	11.0	Publications
38	CCRL1	chemokine (C-C motif) receptor-like 1	11.0	Publications
39	IFNK	interferon, kappa	11.0	Publications
40	SPRR1A	small proline-rich protein 1A	11.0	Publications
41	S100A14	S100 calcium binding protein A14	11.0	Publications
42	BCL7B	B-cell CLL/lymphoma 7B	11.0	Publications, UniProt Related, Functions
43	LOR	loricrin	11.0	Publications
44	DEFB103B	defensin, beta 103B	11.0	Publications
45	ADAT3	adenosine deaminase, tRNA-specific 3	11.0
46	RNASE2	ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)	11.0	Publications
47	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	UniProt Related, Publications
48	CCR10	chemokine (C-C motif) receptor 10	11.0	Publications
49	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
50	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications

Pathways related to atopic dermatitis according to GeneDecks:

(show top 50)    (show all 155)

id	Pathway	Score	Top Affiliating Genes
1	STAT3 Pathway36	14.1	BCL2, CD2, CD80, IL10, IL12A, IL12B
2	Akt Signaling36	13.8	PDE3B, SEMA3A, CD2, CD80, ITGA6, ITGAM
3	Tec Kinases Signaling36	13.5	KITLG, SEMA3A, BDNF, BCL2, CD2, CD80
4	p38 Signaling36	13.5	KITLG, SEMA3A, BDNF, BCL2, CD2, CD80
5	IL-6 Pathway36	13.4	CD2, CD80, IL10, IL12A, IL12B, IL16
6	Antioxidant Action of Vitamin-C36	13.2	KITLG, SEMA3A, BDNF, BCL2, JUN, CD2
7	RAR-Gamma-RXR-Alpha Degradation36	13.1	CD2, CD80, IL12A, IL15, IL16, IL2
8	Molecular Mechanisms of Cancer36	13.0	KITLG, SEMA3A, BDNF, BCL2, JUN, CD2
9	PGC1Alpha Pathway36	12.9	BCL2, CD2, CD80, IL12A, IL12B, IL13
10	Immune System38	12.9	REL, VCAM1, BLMH, LGALS3, CIITA, S100B
11	all-trans-Retinoic Acid Signaling in Brain36	12.8	BCL2, CD2, CD80, IL10, IL12A, IL12B
12	NFAT Signaling and Lymphocyte Interactions36	12.7	BCL2, CD2, CD80, FCER1A, FCER2, IL12A
13	Transendothelial Migration of Leukocytes36	12.7	VCAM1, CLDN1, ITGA6, ITGAM, MMP10, MMP9
14	Regulation of eIF4 and p70S6K36	12.7	CD2, CD80, ITGA6, ITGAM, IL12A, IL12B
15	MIF Mediated Glucocorticoid Regulation36	12.7	BCL2, CD2, CD14, CD80, MIF, IL10
16	PEDF Induced Signaling36	12.6	RELA, BDNF, BCL2, CD2, CD80, IL10
17	SOCS Pathway36	12.5	BCL2, CD2, CD80, IL10, IL12A, IL12B
18	Chemokine signaling pathway20	12.5	RELA, IL8, CCL4, CCL7, CCL26, CCR6
19	MIF Regulation of Innate Immune Cells36	12.4	BCL2, JUN, CD2, CD14, CD80, MIF
20	PAK Pathway36	12.4	KITLG, SEMA3A, BDNF, BCL2, CD2, CD80
21	TGF-Beta Pathway36	12.2	KITLG, SEMA3A, BDNF, BCL2, JUN, CD2
22	MAPK Family Pathway36	12.2	KITLG, SEMA3A, BDNF, BCL2, JUN, CD2
23	Rho Family GTPases36	12.0	KITLG, SEMA3A, VIM, BDNF, BCL2, JUN
24	Chemokine Signaling36	12.0	JUN, IL8, CCL4, CCL7, CCL26, CCR6
25	Jak-STAT signaling pathway20	11.9	LEP, IL10, IL12A, IL12B, IL12RB1, IL12RB2
26	JAK-STAT Pathway36	11.7	KITLG, SEMA3A, BDNF, BCL2, JUN, CD2
27	Cell adhesion molecules (CAMs)20	11.3	SELL, SELP, CLDN1, CD2, CD86, CD8A
28	Asthma20	11.3	MS4A2, CD40LG, CD40, FCER1A, IL10, IL13
29	Bacterial infections in CF airways41	11.1	REL, RELA, RELB, SFTPD, MUC1, TLR1
30	THC Differentiation Pathway36	11.0	CD86, IL10, IL12A, IL12B, IL12RB1, IL12RB2
31	Hematopoietic cell lineage20	11.0	KITLG, CD2, CD36, CD8A, CD14, CD7
32	Th1 Differentiation37	10.9	JUN, CD86, CD80, IL10, IL12A, IL12B
33	Intestinal immune network for IgA production20	10.9	CD86, CD40LG, CD80, CD40, IL10, IL15
34	Graft-versus-host disease20	10.8	CD86, CD80, IL1A, IL2, HLA-A, HLA-B
35	JNK Pathway36	10.8	KITLG, BCL2, JUN, CD2, CD80, IL2
36	Immune response_TLR signaling pathways41	10.8	REL, RELA, RELB, JUN, CD14, IRAK3
37	Immune response Toll-like receptor (TLR) ligands and common TLR signaling pathway leading to cell proinflammatory response10	10.8	REL, RELB, JUN, CD14, IRAK3, IL6
38	NF-KappaB Family Pathway36	10.6	REL, RELA, RELB, KITLG, SEMA3A, BDNF
39	NF-KappaB (p50-p65) Pathway36	10.4	RELA, KITLG, SEMA3A, BDNF, IRAK3, IL1A
40	Cytokine Network36	10.4	IL10, IL12A, IL12B, IL13, IL15, IL16
41	Malaria20	10.3	SELE, SELP, VCAM1, CD36, CD40LG, CD40
42	Toll-like receptor signaling pathway20	10.2	RELA, JUN, CD86, CD14, CD80, CD40
43	Autoimmune thyroid disease20	10.1	CD86, CD40LG, CD80, CD40, GZMB, IL10
44	Type I diabetes mellitus20	10.1	CD86, CD80, GZMB, IL12A, IL12B, IL1A
45	Chagas disease (American trypanosomiasis)20	10.0	RELA, JUN, IL10, IL12A, IL12B, IL1B
46	Pertussis20	9.9	RELA, JUN, CD14, ITGAM, IL10, IL12A
47	Influenza A20	9.9	RELA, CIITA, JUN, IL12A, IL12B, IL18
48	Toxoplasmosis20	9.9	RELA, BCL2, CIITA, CD40LG, CD40, ITGA6
49	Tuberculosis20	9.8	RELA, BCL2, CIITA, CD14, ITGAM, FCGR1A
50	Rheumatoid arthritis20	9.4	VEGFA, JUN, CD86, CD80, IL15, IL17A

Compounds related to atopic dermatitis according to GeneDecks:

(show top 50)    (show all 472)

id	Compound	Score	Top Affiliating Genes
1	calcium32 9 18 9	19.6	PI3, PDE3B, PDE4A, REL, RELA, KITLG
2	allergens32	13.7	SFTPD, CMA1, LGALS3, CIITA, LALBA, S100A8
3	nitric oxide32 9 18 9	16.4	PDE3B, PDE4A, REL, KITLG, SFTPD, SELE
4	atp32	12.8	PDE3B, PDE4A, VDAC2, BDNF, LGALS3, LBR
5	pge232	12.3	PDE3B, PDE4A, SELE, VIP, VCAM1, CIITA
6	glucose32	12.1	PDE4A, LALBA, S100B, AVP, CD2, GZMB
7	oxygen32 18	12.8	PI3, KITLG, SFTPD, BDNF, BCL2, LGALS3
8	cysteine32	11.6	PI3, REL, SFTPD, SELP, SERPINB4, NAT2
9	fmlp32	11.6	PDE4A, SELL, SELP, VIM, VCAM1, S100A9
10	nacl32	11.6	BDNF, LALBA, S100A1, S100A4, S100A6, GZMB
11	salbutamol32 34 9 18 9	15.6	PDE3B, PDE4A, KITLG, VIP, VCAM1, CD79A
12	capsaicin32	11.4	SELE, VIP, CMA1, BDNF, LEP, IL5
13	con a32	11.3	LBR, CD79A, CD2, CD69, IL10, IL18
14	rolipram32 42	12.2	PDE3B, PDE4A, SELE, SELL, ITGAM, IL10
15	nicotine32 34 9 9	14.1	SELL, IVL, FLG, TMPO, PDYN, OPRK1
16	mannose32	11.1	SFTPD, LGALS3, CIITA, CD79A, CD69, CD86
17	n-formylmethionyl-leucylphenylalanine32	11.1	SELL, SELP, MPO, ITGAM, IL1A, IL3
18	arginine32	11.0	PDE4A, VIP, BGLAP, LEP, LBR, LALBA
19	theophylline32 9 18 9	14.0	PDE3B, PDE4A, SELL, SELP, CD79A, CD40LG
20	budesonide32 42 9 9	13.8	PDE4A, KITLG, SFTPD, BGLAP, CD36, IL5RA
21	12-o-tetradecanoylphorbol 13-acetate32	10.8	LBR, IVL, ITGAM, MMP10, MMP9, GZMB
22	aprotinin32 9 9	12.7	SELP, VIP, LALBA, MMP9, IL1A, IGF1
23	aspartate32	10.7	SELP, VIM, VIP, BDNF, LGMN, LALBA
24	dmso32	10.6	KITLG, SELP, VIM, BCL2A1, S100A9, CD36
25	rituximab32 34 9 9	13.6	BCL2, CD79A, CD40LG, CD80, CD40, FCGR1A
26	egcg32	10.6	IVL, IL1A, CCL5, IGFBP3, ELANE, TIMP1
27	fibrinogen32	10.6	SELE, SELP, VCAM1, LGALS3, LEP, LALBA
28	thapsigargin32 42	11.5	VIP, BDNF, BCL2, S100A6, CD36, CD69
29	heparin32 9 18 9	13.5	KITLG, VIM, CMA1, BGLAP, LGALS3, LBR
30	glatiramer acetate32 9 9	12.4	BDNF, CIITA, IL10, IL13, IL2, IL4
31	ivig32	10.4	FCGR1A, FCGR3A, IL1RAPL2, IL3, MBP, CCL4
32	herbimycin a32 42	11.3	KITLG, SELE, SELL, VCAM1, JUN, CD36
33	glutamate32	10.3	VIM, VIP, BCL2A1, LGALS3, LEP, LALBA
34	calcitriol32 42 9 18 9	14.2	KITLG, BGLAP, S100A8, S100A9, JUN, CD36
35	5 aminosalicylic acid32	10.1	NAT2, MPO, IL10, IL12B, IL1B, IL2RA
36	gnrh32	10.1	KITLG, SELL, VIM, LEP, KAL1, CD69
37	mip 1alpha32	10.0	IL10, IL13, IL1B, IL3, IL4, IL6
38	ribavirin32 34 9 9	13.0	LEP, LBR, CD40LG, MMP9, IL10, IL18
39	prednisolone32 9 9	12.0	KITLG, SFTPD, SELL, VIP, VCAM1, BGLAP
40	infliximab32 9 9	11.9	SELE, VEGFA, BGLAP, LBR, FLG, IL10
41	dexamethasone32 42 34 9 9	13.9	PI3, PDE4A, REL, KITLG, SFTPD, SELL
42	cholesterol32 9 18 9	12.8	PDE3B, KITLG, SFTPD, SELE, SELP, NAT2
43	cyclosporin a32 42	10.7	PI3, PDE4A, REL, KITLG, SELP, VIP
44	sulfasalazine32 9 9	11.6	SELE, NAT2, MPO, CD79A, CD40LG, IL12B
45	opiate32	9.5	CCR5, CCR3, F2RL1, GNAI1, HRH1, NTRK1
46	folate32	9.4	SELE, VIM, NAT2, VCAM1, MUC1, CD79A
47	prostacyclin32	9.4	PDE3B, PDE4A, SELE, SELP, VIP, VEGFA
48	valine32	9.3	VIM, VIP, BDNF, S100B, MPO, GSTM1
49	cisplatin32 34 9 9	11.6	KITLG, VEGFA, BGLAP, BDNF, BCL2, LGALS3
50	pdtc32	8.5	SELE, VCAM1, BCL2, JUN, CD40, MMP9

Cellular components related to atopic dermatitis according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:005576	12.8	CSN1S1, CSN3, CST6, POMC, NPY, CP
2	plasma membrane	GO:005886	12.5	HTR1A, TNFSF13B, TNFSF18, PTGDR, PTGDR2, TBXA2R
3	extracellular space	GO:005615	12.2	IL9, CCR3, CCL3, CCL24, CCL21, CCL18
4	integral to plasma membrane	GO:005887	11.8	NGFR, EMR1, ADRB2, HAS2, C5AR1, SLC6A4
5	external side of plasma membrane	GO:009897	11.7	SELL, SELP, VCAM1, MS4A2, CD79A, CD2
6	cornified envelope	GO:001533	11.4	CSTA, CST6, SPRR1B, SPRR1A, HRNR, LOR
7	secretory granule	GO:030141	9.8	DEFA5, ELANE, CTSG, CTSL2, HSPD1, APOA1
8	cell surface	GO:009986	9.6	NTRK1, NOD2, NGFR, ELANE, HBEGF, TLR2
9	cytosol	GO:005829	9.2	NR3C1, SMAD3, PLA2G4D, NOD1, NOD2, NLRC4

Biological processes related to atopic dermatitis according to GeneDecks:

(show top 50)    (show all 82)

id	Name	GO ID	Score	Top Affiliating Genes
1	immune response	GO:006955	14.6	SERPINB4, CIITA, CD86, CD8A, CD7, FCGR1A
2	chemotaxis	GO:006935	13.4	S100A8, S100A9, KAL1, IL4, CCL4, CCL7
3	inflammatory response	GO:006954	13.2	RELA, SELE, SELP, CHI3L1, S100A8, S100A9
4	signal transduction	GO:007165	13.1	PDE4A, KITLG, LALBA, S100A10, S100A6, S100A9
5	defense response to bacterium	GO:042742	12.8	LALBA, S100A14, IL10, CCL20, IFNG, CAMP
6	cell-cell signaling	GO:007267	12.3	LALBA, S100A9, AVP, CD86, CD80, IL10
7	keratinization	GO:031424	11.9	CNFN, LCE3A, LCE3B, LCE3C, LCE5A, IVL
8	defense response	GO:006952	11.7	MPO, CD83, MICU1, IL31RA, IL32, IFNK
9	keratinocyte differentiation	GO:030216	11.6	CLIC4, S100A7, CDSN, IVL, FLG, LOR
10	positive regulation of inflammatory response	GO:050729	11.4	IL12B, IL15, IL18, IL1RL1, IL2, CCL3
11	G-protein coupled receptor signaling pathway	GO:007186	11.4	VIP, MS4A2, IL8, APOA1, APOE, CCL2
12	positive regulation of tumor necrosis factor production	GO:032760	11.3	CD36, CD14, IL12B, IL18, CCL3, IFNG
13	eosinophil chemotaxis	GO:048245	11.2	CCL7, CCL11, CCR3, CCL3, CCL24, CCL13
14	epidermis development	GO:008544	11.2	SATB1, S100A7, CDSN, FABP5, SPRR1A, SPRR1B
15	innate immune response	GO:045087	11.2	RELA, SFTPD, BCL2, LGALS3, LGMN, S100A7
16	negative regulation of growth of symbiont in host	GO:044130	11.1	CD36, IL10, IL12B, MBL2, IFNG, CAMP
17	cytokine-mediated signaling pathway	GO:019221	11.1	RELA, VCAM1, CIITA, IRAK3, IRF2, FCGR1A
18	chemokine-mediated signaling pathway	GO:070098	11.1	CCR6, CCL2, CCR4, CCRL1, CCR5, CCR3
19	cellular response to tumor necrosis factor	GO:071356	11.1	RELA, CHI3L1, IL18, IL8, CCL2, CCL3
20	positive regulation of interferon-gamma production	GO:032729	11.1	CD40LG, IL12A, IL12B, IL12RB1, IL12RB2, IL18
21	elevation of cytosolic calcium ion concentration	GO:007204	11.1	AVP, IL1B, IL2, CCR6, CCR10, CCR4
22	response to lipopolysaccharide	GO:032496	11.1	SELE, SELP, S100A14, S100A7, S100A8, S100A9
23	positive regulation of ERK1 and ERK2 cascade	GO:070374	11.0	CHI3L1, S100A7, MIF, IL1A, IL1B, CCL3
24	positive regulation of interleukin-12 production	GO:032735	11.0	CD36, CD40LG, CD40, IL12B, IFNG, HSPD1
25	positive regulation of B cell proliferation	GO:030890	10.9	BCL2, CD40LG, CD40, MIF, IL13, IL2
26	virus-host interaction	GO:019048	10.9	RELA, VIM, NACA, VCAM1, CLDN1, SATB1
27	interferon-gamma-mediated signaling pathway	GO:060333	10.8	VCAM1, CIITA, IRF2, FCGR1A, IFNG, ICAM1
28	defense response to Gram-positive bacterium	GO:050830	10.8	CD36, IL12A, IL6, MBL2, CAMP, TNF
29	positive regulation of interleukin-10 production	GO:032733	10.7	CD40LG, CD83, IL12B, IL4, HSPD1, NOD2
30	cellular response to interleukin-1	GO:071347	10.7	RELA, CHI3L1, MMP9, IL17A, IL8, CCL2
31	positive regulation of I-kappaB kinase/NF-kappaB cascade	GO:043123	10.6	REL, RELA, S100A4, S100B, CD36, CD40
32	positive regulation of angiogenesis	GO:045766	10.6	VEGFA, CHI3L1, MMP9, IL1A, IL1B, CCL11
33	cell surface receptor signaling pathway	GO:007166	10.6	CD2, CD36, CD14, MIF, IL12RB2, IL13RA1
34	positive regulation of NF-kappaB transcription factor activity	GO:051092	10.6	RELA, CD40, IRAK3, IL1B, IL6, ICAM1
35	cellular response to lipopolysaccharide	GO:071222	10.6	CD36, CD14, GSTP1, IL10, IL12B, IL8
36	positive regulation of tyrosine phosphorylation of Stat5 protein	GO:042523	10.6	IL12B, IL2, IL3, IL31RA, IL4, IGF1
37	humoral immune response	GO:006959	10.4	BCL2, MS4A2, CD83, IL6, IL7, CCR6
38	defense response to virus	GO:051607	10.3	RELA, BCL2, CD86, CD40, IL12B, IL6
39	positive regulation of interleukin-6 production	GO:032755	10.3	CD36, IL1A, IL1B, IL6, HSPD1, TNF
40	response to ethanol	GO:045471	10.3	BGLAP, BCL2, S100A8, S100A9, AVP, MMP9
41	lipopolysaccharide-mediated signaling pathway	GO:031663	10.2	IL18, IL1B, CCL2, CCL3, CCL5, TNF
42	response to nicotine	GO:035094	10.0	BCL2, AVP, MMP9, IL13, HMOX1, NGF
43	positive regulation of cell proliferation	GO:008284	9.7	VIP, VEGFA, LEP, AVP, CD86, IL12RB2
44	positive regulation of smooth muscle cell proliferation	GO:048661	9.7	JUN, IL13, IL6, CCL5, IGF1, HMOX1
45	anti-apoptosis	GO:006916	9.5	RELA, BDNF, BCL2, BCL2A1, MUC1, MPO
46	response to drug	GO:042493	9.5	PDE4A, BGLAP, BDNF, BCL2, JUN, MMP9
47	response to hypoxia	GO:001666	9.4	VEGFA, VCAM1, BCL2, LEP, MMP9, IL18
48	negative regulation of apoptotic process	GO:043066	8.9	RELA, VEGFA, BCL11B, BCL2, LEP, AVP
49	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.8	RELA, VEGFA, BCL11B, CIITA, JUN, CD40
50	platelet activation	GO:030168	8.4	SELP, VEGFA, CD36, CD40LG, CD40, IL6

Molecular functions related to atopic dermatitis according to GeneDecks:

(show all 11)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemokine activity	GO:008009	12.3	CXCL9, CCL11, CCL2, CCL22, CCL27, CCL26
2	cytokine activity	GO:005125	11.4	IL12A, IL10, MIF, CD40LG, VEGFA, KITLG
3	receptor binding	GO:005102	11.1	TNFSF13B, TNFSF18, NTF3, LTA, DPP4, CX3CL1
4	protein binding	GO:005515	11.1	SOD1, SOCS5, SOCS1, CX3CR1, CX3CL1, OPRK1
5	receptor activity	GO:004872	11.0	NGFR, ABP1, TLR1, TLR2, TLR4, TLR6
6	chemokine receptor activity	GO:004950	10.8	CXCR3, CX3CR1, DARC, CCR3, CCR5, CCRL1
7	cytokine receptor activity	GO:004896	10.7	CSF2RA, IL31RA, IL1RL1, IL13RA1, IL12RB2, IL12RB1
8	C-C chemokine receptor activity	GO:016493	10.7	CCR6, CCR10, CCR4, CCRL1, CCR5, CCR3
9	heparin binding	GO:008201	10.1	CTSG, PF4, ABP1, ELANE, HBEGF, PRG2
10	growth factor activity	GO:008083	9.8	IL7, IL9, IGF1, NTF3, NTF4, PPBP
11	protein homodimerization activity	GO:042803	9.5	NFKB1, NLRC4, NOD1, SMAD3, NR3C1, NTRK1