MCID: ATP001
MIFTS: 64

Atopic Dermatitis malady

Skin diseases, Neuronal diseases, Immune diseases categories
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Summaries for Atopic Dermatitis

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Sources:
8Disease Ontology, 65Wikipedia, 47OMIM, 33MalaCards
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Disease Ontology:8 A dermatitis that is a chronically relapsing inflammatory allergic response located in the skin that causes itching and flaking.

MalaCards: Atopic Dermatitis, also known as besnier's prurigo, is related to dermatitis and psoriasis. An important gene associated with Atopic Dermatitis is KLK7 (kallikrein-related peptidase 7), and among its related pathways are IL4-mediated signaling events and Peptide ligand-binding receptors. The drugs betamethasone and betamethasone acetate and the compounds levocetirizine and roxithromycin have been mentioned in the context of this disorder. Affiliated tissues include the skin, skin and t cells.

Wikipedia:65 Atopic dermatitis (AD) also known as atopic eczema or eczema is a type of dermatitis, an inflammatory,... more...

Description from OMIM:47 603165

Aliases & Classifications for Atopic Dermatitis

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Sources:
8Disease Ontology, 10DISEASES, 62UMLS, 45Novoseek, 47OMIM, 58SNOMED-CT, 35MeSH, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Skin diseases, Neuronal diseases, Immune diseases


Aliases & Descriptions:

atopic dermatitis 8 10
besnier's prurigo 8 62
atopic neurodermatitis 8
atopic dermatitis nos 8
allergic dermatitis 8
dermatitis, atopic 62
allergic eczema 8
dermatitis atopic 45
atopic eczema 8


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Disease Ontology8 DOID:3310
OMIM47 603165
MeSH35 D003876
ICD1025 L20, L20.0

Related Diseases for Atopic Dermatitis

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Atopic Dermatitis family:

Dermatitis, Atopic 2 Dermatitis, Atopic 1
Dermatitis, Atopic 6 Dermatitis, Atopic 7
Dermatitis, Atopic 5 Dermatitis, Atopic 4
Dermatitis, Atopic 3

Diseases related to Atopic Dermatitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 200)
idRelated DiseaseScoreTop Affiliating Genes
1dermatitis32.3FLG, IL31, CCL11, CCL22, CCL18, CCL17
2psoriasis31.3CCL22, IL31, CCL27, CCL11, CCL18, CCL17
3asthma31.2CCL22, CCL17, HRH1, FLG, IGHE, CCL11
4eczema herpeticum31.2IGHE
5food allergy31.2IGHE, CCL11
6contact dermatitis31.1IGHE, FLG
7atopy31.1IGHE, FLG, CCL17, CCL11, CCL22
8allergic contact dermatitis31.0FLG, CCL27
9rhinitis30.8CCL11, HRH1, IGHE
10eosinophilia30.8CCL17, CCL11, CCL27, IGHE
11keratoconjunctivitis30.8CCL11
12skin disease30.7IGHE, FLG, CCL17, CCL18, CCL11, CCL27
13netherton syndrome30.6IGHE, KLK7
14allergic rhinitis30.6IGHE, CCL11, HRH1
15allergic asthma30.6IGHE, FLG, CCL17, CCL11, HRH1
16conjunctivitis30.5IGHE, HRH1
17bronchitis30.4IGHE, CCL11
18rheumatoid arthritis30.4CCL27, FLG, CCL11, HRH1, CCL18
19eosinophilic gastroenteritis30.3IGHE, CCL11
20vernal keratoconjunctivitis30.2IGHE, CCL11
21allergic conjunctivitis30.2CCL11, HRH1, IGHE
22bullous pemphigoid30.1CCL11, CCL17, FLG, IGHE
23mycosis fungoides30.1CCL17, CCL22, CCL27
24pneumonia30.0HRH1, CCL11, CCL22, CCL18, CCL17
25ichthyosis vulgaris10.7
26blindness10.7
27impetigo10.5
28egg allergy10.5
29alopecia10.5
30cutaneous t cell lymphoma10.5
31urticaria10.5
32hyper ige syndrome10.5
33molluscum contagiosum10.4
34lichen planus10.4
35vaccinia10.4
36neurodermatitis10.4
37alopecia areata10.4
38chronic actinic dermatitis10.4
39arthritis10.4
40endotheliitis10.4
41vitiligo10.3
42acne10.3
43herpes simplex10.3
44retinitis10.3
45rosacea10.2
46protein-losing enteropathy10.2
47wiskott-aldrich syndrome10.2
48pityriasis versicolor10.2
49ritter's disease10.2
50toxic shock syndrome10.2

Graphical network of the top 20 diseases related to Atopic Dermatitis:



Diseases related to atopic dermatitis

Symptoms for Atopic Dermatitis

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Sources:
47OMIM
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Clinical features from OMIM:

603165

Drugs & Therapeutics for Atopic Dermatitis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
See all sources

Genetic Tests for Atopic Dermatitis

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Anatomical Context for Atopic Dermatitis

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Sources:
33MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Atopic Dermatitis:

33
Skin, T cells, Testes, Monocytes, Colon, Thymus, B cells, Breast, Endothelial, Whole blood, Liver, Bone, Thyroid, Tonsil, Myeloid, Kidney

FMA organs/tissues related to Atopic Dermatitis:

14
The skin

Animal Models for Atopic Dermatitis or affiliated genes

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Publications for Atopic Dermatitis

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Sources:
52PubMed
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Articles related to Atopic Dermatitis:

(show top 50)    (show all 1668)
idTitleAuthorsYear
1
Human I^-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis. (23647067)
2013
2
Effects of Korean red ginseng extract on the prevention of atopic dermatitis and its mechanism on early lesions in a murine model. (23149290)
2013
3
Serum visfatin levels in patients with atopic dermatitis and cutaneous T-cell lymphoma. (24001451)
2013
4
Skin-specific expression of IL-33 activates group 2 innate lymphoid cells and elicits atopic dermatitis-like inflammation in mice. (23918359)
2013
5
Difficult to control atopic dermatitis. (23663504)
2013
6
Evaluation of food allergy in patients with atopic dermatitis. (24229818)
2013
7
Treatment of the chronic itch of atopic dermatitis using standard drugs and kampo medicines. (23902969)
2013
8
Cultivated ginseng inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis-like skin lesions in NC/Nga mice and TNF-I+/IFN-I^-induced TARC activation in HaCaT cells. (23454147)
2013
9
Effect of bathing on atopic dermatitis during the summer season. (23130333)
2012
10
Impact of interactive web-based education with mobile and email-based support of general practitioners on treatment and referral patterns of patients with atopic dermatitis: randomized controlled trial. (23249479)
2012
11
Clinical presentation of atopic dermatitis by filaggrin gene mutation status during the first 7 years of life in a prospective cohort study. (23166590)
2012
12
Inflammation-driven dermal lymphangiogenesis in atopic dermatitis is associated with CD11b+ macrophage recruitment and VEGF-C up-regulation in the IL-4-transgenic mouse model. (22574929)
2012
13
Keratinocytes under Fire of Proinflammatory Cytokines: Bona Fide Innate Immune Cells Involved in the Physiopathology of Chronic Atopic Dermatitis and Psoriasis. (23193414)
2012
14
Role of food allergy in childhood atopic dermatitis. (21679336)
2012
15
Kaposi's sarcoma in an atopic dermatitis patient: a case report and a review of literature. (21385206)
2011
16
Mutations in the filaggrin gene in Han Chinese patients with atopic dermatitis. (21039602)
2011
17
Atopic dermatitis - current insights into path physiology and management]. (20336617)
2010
18
Analysis of four prevalent filaggrin mutations (R501X, 2282del4, R2447X and S3247X) in Austrian and German patients with atopic dermatitis. (19874431)
2010
19
CC chemokines as potential immunologic markers correlated with clinical improvement of atopic dermatitis patients by immunotherapy. (19758316)
2010
20
Murine atopic dermatitis responds to peroxisome proliferator-activated receptors alpha and beta/delta (but not gamma) and liver X receptor activators. (19818482)
2010
21
Association of single nucleotide polymorphism of interleukin-18 with atopic dermatitis. (19453784)
2010
22
Expression of chemokines and chemokine receptors in lesional and nonlesional upper skin of patients with atopic dermatitis. (19767072)
2009
23
Our evolving understanding of the functional role of filaggrin in atopic dermatitis. (19733296)
2009
24
Defective killing of Staphylococcus aureus in atopic dermatitis is associated with reduced mobilization of human beta-defensin-3. (18538383)
2008
25
Staphylococcus aureus skin colonization in atopic dermatitis children is associated with decreased IFN-gamma production by peripheral blood CD4+ and CD8+ T cells. (17662038)
2008
26
Evening primrose oil is effective in atopic dermatitis: a randomized placebo-controlled trial. (19052401)
2008
27
The effect of wet-wrap dressing on epidermal barrier in patients with atopic dermatitis. (17958842)
2007
28
Clinical relevance of nerve growth factor serum levels in patients with atopic dermatitis and psoriasis. (17579279)
2007
29
Ingestion of heat-treated Lactobacillus rhamnosus GG prevents development of atopic dermatitis in NC/Nga mice. (17250703)
2007
30
Analysis of components of the CD14/TLR system on leukocytes of patients with atopic dermatitis. (17284926)
2007
31
Specific immunotherapy in the treatment of patients with atopic dermatitis--results of double blind placebo controlled study]. (17405298)
2006
32
Nocturnal wrist movements are correlated with objective clinical scores and plasma chemokine levels in children with atopic dermatitis. (16536804)
2006
33
Deficiency of dermcidin-derived antimicrobial peptides in sweat of patients with atopic dermatitis correlates with an impaired innate defense of human skin in vivo. (15944307)
2005
34
Inflammatory mediators in patients with atopic dermatitis after treatment with transfer factor]. (15491080)
2004
35
Effect of staphylococcal enterotoxin B on specific antibody production in children with atopic dermatitis. (12635580)
2003
36
Flow cytometric analysis of IL-4, IL-13 and IFN-gamma expression in peripheral blood mononuclear cells and detection of circulating IL-13 in patients with atopic dermatitis provide evidence for the involvement of type 2 cytokines in the disease. (12007717)
2002
37
Dichotomic nature of atopic dermatitis reflected by combined analysis of monocyte immunophenotyping and single nucleotide polymorphisms of the interleukin-4/interleukin-13 receptor gene: the dichotomy of extrinsic and intrinsic atopic dermatitis. (12406333)
2002
38
Etiologic implication of foods in atopic dermatitis: evidence in favor]. (11988141)
2002
39
Decreased levels of CXCR3 transcripts in peripheral blood mononuclear cells from patients with atopic dermatitis and with cutaneous diseases associated with eosinophilia. (11480592)
2001
40
Autoantibodies to DFS 70 kd/transcription coactivator p75 in atopic dermatitis and other conditions. (10856157)
2000
41
Soluble E-selectin correlates with disease activity in cyclosporin A-treated patients with atopic dermatitis. (10195358)
1999
42
Acute inflammatory demyelinating polyradiculoneuropathy associated with hyperIgEemia and atopic dermatitis. (9562273)
1998
43
Long-term therapy with recombinant interferon-gamma (rIFN-gamma) for atopic dermatitis. (9532976)
1998
44
The chemotactic activity of T-lymphocytes in response to interleukin 8 is significantly decreased in patients with psoriasis and atopic dermatitis. (9028795)
1996
45
RANTES mRNA expression in skin and colon of patients with atopic dermatitis. (8906106)
1996
46
Corticosteroid-induced apoptosis of eosinophils in atopic dermatitis patients. (10036642)
1996
47
Systemic interferon gamma treatment in severe atopic dermatitis. (8315079)
1993
48
Increased plasma tumour necrosis factor-alpha concentration in atopic dermatitis. (1575548)
1992
49
Functional characterization of skin-infiltrating lymphocytes in atopic dermatitis. (1721013)
1991
50
Atopic dermatitis and Ritter's disease: differential diagnosis by means of total and specific serum IgE. (147160)
1978

Variations for Atopic Dermatitis

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Expression for genes affiliated with Atopic Dermatitis

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Sources:
2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atopic Dermatitis

Search GEO for disease gene expression data for Atopic Dermatitis.

Pathways for genes affiliated with Atopic Dermatitis

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Sources:
50PathCards, 38NCBI BioSystems Database, 55Reactome, 30KEGG, 53QIAGEN, 54R&D Systems
See all sources

Pathways related to Atopic Dermatitis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7CCL11, CCL17, IGHE
2
Show member pathways
9.1CCL17, CCL22, CCL11, CCL27, HRH1
3
Show member pathways
8.8CCL27, CCL11, CCL22, CCL18, CCL17
4
Show member pathways
8.8CCL27, CCL11, CCL22, CCL18, CCL17
5
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
6
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
7
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
8
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
9
Show member pathways
8.8CCL17, CCL18, CCL22, CCL11, CCL27
10
Show member pathways
8.5NACA, CCL17, CCL18, CCL22, CCL11, CCL27

Compounds for genes affiliated with Atopic Dermatitis

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Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB, 51PharmGKB
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Compounds related to Atopic Dermatitis according to GeneCards/GeneDecks:

(show all 39)
idCompoundScoreTop Affiliating Genes
1levocetirizine4510.4CCL11, HRH1
2roxithromycin45 29 1112.3CCL17, CCL11
3unicap4510.2IGHE, CCL11
4mepyramine maleate6110.2DHX34, DHX8, HRH1
5histamine dihydrochloride6110.2DHX34, DHX8, HRH1
6clemastine fumarate6110.2DHX34, DHX8, HRH1
72-pyridylethylamine dihydrochloride6110.1DHX34, DHX8, HRH1
8astemizole45 61 29 1113.1DHX34, DHX8, HRH1
9oxatomide4510.1HRH1, IGHE
10desloratadine45 1111.1HRH1, IGHE
11nedocromil sodium4510.1IGHE, HRH1
12loratadine45 24 1112.0HRH1, IGHE
13anti-histamine4510.0HRH1, CCL11, IGHE
14sodium cromoglycate4510.0HRH1, CCL11, IGHE
15pertussis4510.0CCL11, CCL22, IGHE
16cetirizine45 29 24 1113.0IGHE, CCL11, HRH1
17montelukast45 51 29 1113.0IGHE, CCL11
18methacholine45 51 1112.0CCL11, CCL22, IGHE
19ketotifen45 1111.0HRH1, CCL11, IGHE
20olopatadine45 1111.0IGHE, CCL17, HRH1
21tacrolimus45 51 1112.0HRH1, CCL11, CCL22, CCL17
22azelastine45 1111.0HRH1, IGHE
23prostaglandin459.9HRH1, CCL11, CCL22
24salbutamol45 51 29 24 1113.9CCL11, IGHE
25aspirin45 51 29 2412.8CCL22, CCL11, HRH1
26larc459.8CCL17, CCL18, CCL22
27budesonide45 51 1111.8CCL11, IGHE
28fluticasone propionate45 51 61 1112.6CCL11, IGHE
29cyclosporin a45 29 6111.6IGHE, CCL17, CCL22, CCL11, HRH1
30pge2459.5CCL22, CCL11, CCL27, HRH1
31histamine45 29 2411.4HRH1, IL31, CCL11, CCL22, IGHE
32ccl345 2910.2CCL17, CCL18, CCL22, CCL11, CCL27
33ccl445 2910.2CCL17, CCL18, CCL22, CCL11, CCL27
34allergens459.2IGHE, FLG, CCL17, CCL11, CCL27, HRH1
35rantes458.9CCL17, CCL18, CCL22, CCL11, CCL27, HRH1
36tarc458.8CCL27, CCL11, CCL22, CCL18, CCL17, IGHE
37alanine458.7IGHE, CCL18, CCL11, CCL27, HRH1
38dexamethasone45 51 29 1111.5IGHE, CCL17, CCL18, CCL22, CCL11, CCL27
39calcium45 51 24 1111.4FLG, CCL17, CCL18, CCL22, CCL11, CCL27

GO Terms for genes affiliated with Atopic Dermatitis

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Sources:
16Gene Ontology
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Cellular components related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055768.8CCL17, CCL22, CCL11, CCL27, KLK7, IGHE
2extracellular spaceGO:0056158.1IL31, CCL27, CCL11, CCL22, CCL18, CCL17

Biological processes related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1eosinophil chemotaxisGO:04824510.0HRH1, CCL11
2cell chemotaxisGO:0603269.0CCL17, CCL18, CCL22, CCL27
3inflammatory responseGO:0069548.9CCL17, CCL18, CCL22, CCL11, HRH1
4chemotaxisGO:0069358.9CCL27, CCL11, CCL22, CCL18, CCL17
5cell-cell signalingGO:0072678.6CCL27, CCL22, CCL18, CCL17
6immune responseGO:0069558.3IGHE, CCL17, CCL18, CCL22, CCL11, CCL27

Molecular functions related to Atopic Dermatitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080098.8CCL27, CCL11, CCL22, CCL18, CCL17

Products for genes affiliated with Atopic Dermatitis

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopic Dermatitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet