MCID: ATP013
MIFTS: 41

Atopic Keratoconjunctivitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 51 65

Characteristics:

Orphanet epidemiological data:

51
atopic keratoconjunctivitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Orphanet51 163934
ICD10 via Orphanet28 H16.2
UMLS via Orphanet66 C1274788
UMLS65 C1274788

Summaries for Atopic Keratoconjunctivitis

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MalaCards based summary: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and lattice corneal dystrophy. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (C-C Motif Chemokine Ligand 22), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include breast, heart and thyroid, and related mouse phenotypes are digestive/alimentary and respiratory system.

Related Diseases for Atopic Keratoconjunctivitis

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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 139)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis10.8
2lattice corneal dystrophy10.6IL3, IL5
3loeffler syndrome10.6IL3, IL5
4kyphoscoliotic heart disease10.6IL4, IL5
5status asthmaticus10.6IL4, IL5
6benign paroxysmal positional nystagmus10.5IL4, IL5
7superficial urinary bladder cancer10.5IL4, IL5
8eosinophilic gastroenteritis10.5IL4, IL5
9mobitz type ii atrioventricular block10.5IL4, IL5
10granulomatous amebic encephalitis10.5IL4, IL5
11motor peripheral neuropathy10.5IL4, IL5
12acantholytic variant squamous cell breast carcinoma10.5IL4, IL5
13eosinophilic granulomatosis with polyangiitis10.5IFNG, IL5
14western equine encephalitis10.5IL2, IL3
15prepuce cancer10.5IL4, IL5
16cholesteatoma of attic10.4IFNG, IL5
17melorheostosis10.4IL4, IL5
18orbit lymphoma10.4IFNG, IL5
19familial hyperlipidemia10.4IL4, IL5
20cd45 deficiency10.4IL2, IL4
21maxillary neoplasm10.4IL2, IL4
22cycloplegia10.4IFNG, IL4
23female breast central part cancer10.4IL2, IL5
24disseminated eosinophilic collagen disease10.4IL4, IL5
25enamel caries10.4IL4, IL5
26dioctophymiasis10.4IFNG, IL4
27neonatal infective mastitis10.4IFNG, IL5
28soft tissue sarcoma childhood10.4IFNG, IL3
29acalculous cholecystitis10.4IL4, IL5
30spinal polio10.3IFNG, IL2
31buruli ulcer10.3IFNG, IL4
32chronic conjunctivitis10.3IL2, IL4
33graft-versus-host disease, protection against10.3IFNG, IL2
34early-onset, autosomal dominant alzheimer disease10.3IFNG, IL4
35retroperitoneal germ cell neoplasm10.3CCL22, IL3, IL5
36chronic demyelinizing neuropathy with igm monoclonal10.3IFNG, IL2
37louping ill10.3IFNG, IL2
38central nervous system melanocytic neoplasm10.3IFNG, IL4
39idiopathic interstitial pneumonia10.3CCL22, IL4, IL5
40kohler's disease10.3IL4, IL5, MUC5AC
41soft palate cancer10.3IFNG, IL4
42peanut allergy10.3IGHE, IL4
43hyper-reninism10.3IGHE, IL4
44argentine hemorrhagic fever10.3IFNG, IL2
45craniofacioskeletal syndrome10.3IGHE, IL4
46sarcoid meningitis10.3IFNG, IL4
47opioid abuse10.2IL4, IL5
48diffuse cutaneous mastocytosis10.2IL2, IL3
49meige syndrome10.2IFNG, IL4
50polycystic kidney disease10.2IL2, IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Miconazoleapproved, investigationalPhase 3302622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
2Immunosuppressive AgentsPhase 310422
3Ophthalmic SolutionsPhase 31006
4Pharmaceutical SolutionsPhase 37004
5Immunologic FactorsPhase 318483
6Dermatologic AgentsPhase 34555
7Anti-Infective AgentsPhase 317220
8Antirheumatic AgentsPhase 38496
9Calcineurin InhibitorsPhase 31223
10Antifungal AgentsPhase 33015
11CyclosporinsPhase 3873
12Tetrahydrozoline542

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic KeratoconjunctivitisCompletedNCT00884585Phase 3
2Long-term Topical Cyclosporine for Atopic KeratoconjunctivitisCompletedNCT00987467

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

33
Breast, Heart, Thyroid, Eye, Kidney, Prostate, Lung

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4IFNG, IL2, IL4, IL5, MUC5AC
2MP:00053888.1IFNG, IL2, IL4, IL5, PRG2

Publications for Atopic Keratoconjunctivitis

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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. (25682856)
2015
2
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. (25923050)
2015
3
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. (26278858)
2015
4
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. (25705372)
2014
5
Central corneal thickness in patients with atopic keratoconjunctivitis. (25240805)
2014
6
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
7
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
8
Atopic keratoconjunctivitis: A review. (24342754)
2013
9
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
10
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
11
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
12
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
13
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
14
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
15
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
16
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
17
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
18
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
19
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
20
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. (20482394)
2010
21
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. (18721214)
2009
22
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
23
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
24
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
25
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
26
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
27
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
28
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
29
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
30
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
31
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis. (15548799)
2004
32
A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. (15019322)
2004
33
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
34
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
35
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
36
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
37
Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)
1999
38
Analysis of tears in patients with atopic keratoconjunctivitis, using flow cytometry. (9483587)
1998
39
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
40
A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. (9754182)
1998
41
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry. (9441704)
1997
42
Atopic keratoconjunctivitis. (9269601)
1997
43
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
44
Atopic keratoconjunctivitis. (22823113)
1994
45
Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with long-term topical cyclosporin A. (7842716)
1994
46
Atopic keratoconjunctivitis (AKC). (8344185)
1993
47
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
48
Atopic keratoconjunctivitis. (1976238)
1990
49
Atopic keratoconjunctivitis. (13411162)
1957
50
Atopic keratoconjunctivitis. (13065376)
1953

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL4, IL5
29.6IFNG, IL2
39.6IFNG, IL2
4
Show member pathways
9.6IFNG, IL2
59.4IL3, IL4, IL5
6
Show member pathways
9.4IL2, IL3, IL5
79.3IFNG, IL2, IL3
8
Show member pathways
9.2IFNG, IL2, IL4
99.2IGHE, IL4, IL5
108.9IFNG, IL2, IL4, IL5
118.9IFNG, IL2, IL4, IL5
128.9IFNG, IL2, IL4, IL5
138.9IFNG, IL2, IL4, IL5
14
Show member pathways
8.9IFNG, IL2, IL4, IL5
158.9IFNG, IL2, IL4, IL5
16
Show member pathways
8.9IFNG, IL2, IL3, IL4
17
Show member pathways
8.8IGHE, IL3, IL4, IL5
18
Show member pathways
8.7CCL22, IL2, IL3, IL4, IL5
198.7IFNG, IL2, IL4, PRG2
208.6CCL22, IFNG, IL2, IL4, IL5
21
Show member pathways
8.6IFNG, IL2, IL3, IL4, IL5
22
Show member pathways
8.6IFNG, IL2, IL3, IL4, IL5
23
Show member pathways
8.6IFNG, IL2, IL3, IL4, IL5
248.6IFNG, IL2, IL3, IL4, IL5
25
Show member pathways
8.3CCL22, IFNG, IL2, IL3, IL4, IL5
26
Show member pathways
8.3CCL22, IFNG, IL2, IL3, IL4, IL5
27
Show member pathways
8.0IFNG, IL2, IL3, IL4, IL5, PRG2

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell differentiationGO:004558210.4IL2, IL4
2extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.3IL2, IL4
3positive regulation of chemokine biosynthetic processGO:004508010.3IFNG, IL4
4defense response to protozoanGO:004283210.3IFNG, IL4
5positive regulation of B cell activationGO:005087110.2IGHE, IL4
6positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL4
7positive regulation of B cell proliferationGO:003089010.0IL2, IL4, IL5
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.0IL2, IL3, IL4
9positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.9IL3, IL4, IL5
10epidermal growth factor receptor signaling pathwayGO:00071739.9IL2, IL3, IL5
11cytokine-mediated signaling pathwayGO:00192219.9IFNG, IL3, IL5
12positive regulation of T cell proliferationGO:00421029.8IFNG, IL2, IL4
13positive regulation of GTPase activityGO:00435479.8CCL22, IL3, IL5
14positive regulation of isotype switching to IgG isotypesGO:00483049.7IFNG, IL2, IL4
15vascular endothelial growth factor receptor signaling pathwayGO:00480109.7IL2, IL3, IL5
16insulin receptor signaling pathwayGO:00082869.7IL2, IL3, IL5
17innate immune responseGO:00450878.8IGHE, IL2, IL3, IL5
18defense response to bacteriumGO:00427428.6IFNG, IGHE, PRG2
19positive regulation of cell proliferationGO:00082848.5IFNG, IL2, IL3, IL4, IL5
20immune responseGO:00069558.3CCL22, IFNG, IL2, IL3, IL4, IL5

Sources for Atopic Keratoconjunctivitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet