MCID: ATP013
MIFTS: 45

Atopic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

MalaCards integrated aliases for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 55 69

Characteristics:

Orphanet epidemiological data:

55
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 55  
Rare eye diseases


External Ids:

Orphanet 55 ORPHA163934
UMLS via Orphanet 70 C1274788
ICD10 via Orphanet 33 H16.2
UMLS 69 C1274788

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to keratoconjunctivitis and vernal keratoconjunctivitis, and has symptoms including dry skin, keratoconjunctivitis sicca and corneal opacity. An important gene associated with Atopic Keratoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Cyclosporins have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and t cells.

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 174)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 30.8 IFNG IL2 IL4 IL5 RNASE3
2 vernal keratoconjunctivitis 30.4 IL4 IL5 RNASE3
3 allergic conjunctivitis 29.7 IFNG IL4 IL5 RNASE3
4 ocular cicatricial pemphigoid 29.4 IL4 PRG2 RNASE3
5 conjunctivitis 29.3 IFNG IL2 IL4 IL5 RNASE3
6 dermatitis 29.1 CCL22 IFNG IGHE IL4 IL5 RNASE3
7 dermatitis, atopic 28.5 CCL22 IFNG IGHE IL2 IL4 IL5
8 mycoplasmal pneumonia 10.5 IFNG IL4
9 hyperlucent lung 10.5 IFNG IL4
10 eosinophilic fasciitis 10.5 IFNG IL5
11 baylisascariasis 10.5 IFNG IL4
12 penicillin allergy 10.5 IFNG IL4
13 virus associated hemophagocytic syndrome 10.5 IL2 IL4
14 trichinosis 10.5 IL4 IL5
15 variola major 10.5 IFNG IL2
16 non-suppurative otitis media 10.5 IL4 IL5
17 scleritis 10.5 IL4 IL5
18 autoimmune myocarditis 10.5 IFNG IL2
19 berylliosis 10.5 IFNG IL2
20 orofacial granulomatosis 10.5 IFNG IL4
21 strongyloidiasis 10.4 IFNG IL5
22 immune suppression 10.4 IFNG IL2
23 eosinophilia-myalgia syndrome 10.4 IFNG IL5
24 jak3-deficient severe combined immunodeficiency 10.4 IL2 IL4
25 buruli ulcer 10.4 IFNG IL4
26 ascaris lumbricoides infection 10.4 IFNG IL5
27 eosinophilic meningitis 10.4 IL4 IL5
28 cercarial dermatitis 10.4 IL4 IL5
29 intestinal schistosomiasis 10.4 IL4 IL5
30 clonorchiasis 10.4 IFNG IL2
31 necatoriasis 10.4 CCL22 IL5
32 poliomyelitis 10.4 IFNG IL4
33 seborrheic infantile dermatitis 10.4 IL3 IL5
34 chronic tic disorder 10.4 IL4 IL5
35 crohn's colitis 10.4 IFNG IL2
36 primary systemic mycosis 10.4 IFNG IL4
37 blepharoconjunctivitis 10.4 IL4 RNASE3
38 hypereosinophilic syndrome, idiopathic 10.4 IL3 IL5
39 chronic active epstein-barr virus infection 10.4 IFNG IL2
40 multicentric castleman disease 10.4 IFNG IL5
41 primary amebic meningoencephalitis 10.4 IL4 IL5
42 posterior uveitis 10.4 IFNG IL2
43 loeffler endocarditis 10.4 IL5 RNASE3
44 eales disease 10.4 IFNG IL4
45 cyclic neutropenia 10.4 IFNG IL3
46 paragonimiasis 10.4 IL5 RNASE3
47 cow milk allergy 10.3 IL5 RNASE3
48 intermediate uveitis 10.3 IFNG IL2
49 staphylococcal toxic shock syndrome 10.3 IFNG IGHE
50 chronic eosinophilic pneumonia 10.3 IL5 RNASE3

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

55 31 (show all 9)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 55 31 hallmark (90%) Very frequent (99-80%) HP:0000958
2 keratoconjunctivitis sicca 55 31 hallmark (90%) Very frequent (99-80%) HP:0001097
3 corneal opacity 55 31 hallmark (90%) Very frequent (99-80%) HP:0007957
4 blepharitis 55 31 frequent (33%) Frequent (79-30%) HP:0000498
5 loss of eyelashes 55 31 frequent (33%) Frequent (79-30%) HP:0011457
6 corneal neovascularization 55 31 frequent (33%) Frequent (79-30%) HP:0011496
7 chemosis 55 31 occasional (7.5%) Occasional (29-5%) HP:0012375
8 keratitis 55 Very frequent (99-80%)
9 abnormality of the eyelid 55 Frequent (79-30%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2 Cyclosporins Phase 3
3 Dermatologic Agents Phase 3
4 Ophthalmic Solutions Phase 3
5 Pharmaceutical Solutions Phase 3
6 Anti-Infective Agents Phase 3
7 Antifungal Agents Phase 3
8 Immunosuppressive Agents Phase 3
9 Antirheumatic Agents Phase 3
10 Calcineurin Inhibitors Phase 3
11 Antibodies, Monoclonal Phase 1
12 Immunoglobulins Phase 1
13 Antibodies Phase 1
14 Tetrahydrozoline

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3 Cyclosporine Vehicle;Cyclosporine 0.010%
2 A Study of AK002 in Patients With Atopic Keratoconjunctivitis, Vernal Keratoconjunctivitis, and Perennial Allergic Conjunctivitis Recruiting NCT03379311 Phase 1
3 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic;Cyclosporin 0.05% ophthalmic

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

38
Eye, Skin, T Cells, Bone, Bone Marrow

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 89)
# Title Authors Year
1
Successful Subcutaneous Allergen-Specific Immunotherapy in Refractory Atopic Keratoconjunctivitis: A Case Report. ( 29422859 )
2017
2
Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. ( 28855579 )
2017
3
Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis. ( 28275599 )
2017
4
Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case. ( 28138334 )
2017
5
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. ( 27901637 )
2016
6
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
7
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. ( 28076564 )
2016
8
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. ( 26278858 )
2015
9
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. ( 25682856 )
2015
10
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. ( 25923050 )
2015
11
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. ( 26302769 )
2015
12
Central corneal thickness in patients with atopic keratoconjunctivitis. ( 25240805 )
2014
13
Functional visual acuity assessment of severe atopic keratoconjunctivitis. ( 25289719 )
2014
14
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. ( 25705372 )
2014
15
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. ( 24439439 )
2014
16
Atopic keratoconjunctivitis. ( 23406935 )
2013
17
Atopic keratoconjunctivitis: A review. ( 24342754 )
2013
18
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. ( 23949491 )
2013
19
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? ( 23106347 )
2013
20
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. ( 23886231 )
2013
21
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. ( 22486642 )
2012
22
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. ( 22581322 )
2012
23
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. ( 22378107 )
2012
24
Atopic keratoconjunctivitis: present day diagnosis. ( 22872669 )
2012
25
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. ( 22092652 )
2012
26
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. ( 22275342 )
2012
27
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. ( 22441637 )
2012
28
Topical cyclosporine for atopic keratoconjunctivitis. ( 22972132 )
2012
29
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. ( 22717457 )
2012
30
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. ( 20861732 )
2011
31
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. ( 21541276 )
2011
32
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. ( 22606467 )
2011
33
Systemic cyclosporin A in severe atopic keratoconjunctivitis. ( 20491051 )
2010
34
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. ( 20657166 )
2010
35
Omalizumab for severe atopic keratoconjunctivitis. ( 22791726 )
2010
36
Atopic keratoconjunctivitis and atopic dermatitis. ( 20720488 )
2010
37
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. ( 20482394 )
2010
38
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). ( 19693288 )
2009
39
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. ( 18721214 )
2009
40
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. ( 18724148 )
2008
41
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. ( 18782111 )
2008
42
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. ( 18614131 )
2008
43
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 18584874 )
2008
44
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. ( 17620070 )
2007
45
Clinical grading of atopic keratoconjunctivitis. ( 17873586 )
2007
46
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 17768384 )
2007
47
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. ( 16680103 )
2007
48
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. ( 17893528 )
2007
49
Systemic tacrolimus in the treatment of severe atopic keratoconjunctivitis. ( 17172887 )
2006
50
Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. ( 17177679 )
2006

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 38)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCL22 IFNG IGHE IL2 IL3 IL4
2
Show member pathways
13.48 CCL22 IFNG IL2 IL3 IL4 IL5
3
Show member pathways
13.37 CCL22 IFNG IL2 IL3 IL4 IL5
4
Show member pathways
13.2 CCL22 IFNG IGHE IL2 IL3 IL4
5
Show member pathways
13.13 CCL22 IL2 IL3 IL4 IL5
6 12.7 IFNG IL2 IL3 IL4 IL5
7
Show member pathways
12.61 IFNG IL2 IL3 IL4 IL5 PRG2
8
Show member pathways
12.51 IFNG IGHE IL2 IL4
9
Show member pathways
12.46 IFNG IL2 IL4 IL5
10
Show member pathways
12.45 IGHE IL3 IL4 IL5
11 12.42 IFNG IL2 IL3 IL4
12
Show member pathways
12.38 IFNG IL2 IL3 IL4
13
Show member pathways
12.3 IFNG IL2 IL4 IL5
14
Show member pathways
12.26 IFNG IL2 IL3 IL4 IL5
15
Show member pathways
12.2 IFNG IL4 IL5 MUC5AC
16
Show member pathways
12.18 IFNG IL2 IL4
17
Show member pathways
12.04 IFNG IL2 IL3 IL4 IL5
18
Show member pathways
12.02 IL2 IL3 IL5
19 11.9 IFNG IL2 IL4
20 11.87 CCL22 IGHE IL4
21 11.87 IFNG IL2 IL3 IL4 IL5
22
Show member pathways
11.86 IFNG IL2 IL4
23 11.77 IL3 IL4 IL5
24 11.74 IFNG IL2 IL3
25 11.74 IFNG IL2 IL4 IL5
26 11.71 IFNG IL2 IL4 IL5
27 11.56 IGHE IL4 IL5
28
Show member pathways
11.43 IFNG IL2 IL3 IL4 IL5
29 11.24 IFNG IL4 IL5
30
Show member pathways
11.23 IFNG IL2
31 11.19 IFNG IL2 IL4 IL5
32 11.12 CCL22 IL2 IL3 IL4 IL5
33 11.11 IFNG IL2
34 11.02 CCL22 IFNG IL2 IL4 IL5
35 10.97 IFNG IL2 IL4 IL5
36 10.92 CCL22 IL2 IL3 IL4 IL5 PRG2
37 10.71 IL4 IL5
38 10.5 IFNG IL2 IL3 IL4 IL5

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL22 IFNG IL2 IL3 IL4 IL5
2 extracellular region GO:0005576 9.36 CCL22 IFNG IGHE IL2 IL3 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.76 IFNG IL2 IL3 IL5
2 defense response to bacterium GO:0042742 9.65 IGHE PRG2 RNASE3
3 positive regulation of T cell differentiation GO:0045582 9.43 IL2 IL4
4 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.43 IFNG IL2 IL3
5 regulation of receptor activity GO:0010469 9.43 CCL22 IFNG IL2 IL3 IL4 IL5
6 regulation of regulatory T cell differentiation GO:0045589 9.4 IFNG IL2
7 positive regulation of immunoglobulin secretion GO:0051024 9.37 IL2 IL5
8 positive regulation of B cell proliferation GO:0030890 9.33 IL2 IL4 IL5
9 positive regulation of isotype switching to IgG isotypes GO:0048304 9.32 IL2 IL4
10 immune response GO:0006955 9.23 CCL22 IFNG IGHE IL2 IL3 IL4

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 IL2 IL3 IL5
2 growth factor activity GO:0008083 9.26 IL2 IL3 IL4 IL5
3 cytokine activity GO:0005125 9.1 CCL22 IFNG IL2 IL3 IL4 IL5

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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