MCID: ATP013
MIFTS: 36

Atopic Keratoconjunctivitis malady

Eye diseases category

Summaries for Atopic Keratoconjunctivitis

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32MalaCards
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MalaCards: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and corneal ulcer. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (chemokine (C-C motif) ligand 22), and among its related pathways are Leishmaniasis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include eye, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
48Orphanet, 60UMLS, 26ICD10 via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye diseases


Characteristics (Orphanet epidemiological data):

48
atopic keratoconjunctivitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

atopic keratoconjunctivitis 48 60


External Ids:

ICD10 via Orphanet26 H16.2
SNOMED-CT via Orphanet57 403434009
UMLS via Orphanet61 C1274788

Related Diseases for Atopic Keratoconjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 164)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.5IL5, CCL11
2corneal ulcer30.6MUC5AC, PRG2, CCL11
3atopic dermatitis30.5IL4, CCL11, CCL22
4dermatitis30.4IL4, IL5, IGHE, IFNG, CCR4, CCL11
5alopecia areata30.1IFNG
6conjunctivitis30.1IGHE
7influenza30.1CCL11, IFNG
8allergic conjunctivitis30.1IL4, IL5, IGHE, CCL11
9corneal disease10.1
10stevens-johnson syndrome10.1
11cicatricial pemphigoid10.1
12vernal conjunctivitis10.1
13alopecia10.1
14corneal deposit10.1
15herpes simplex10.1
16keratitis10.1
17keratoconus10.1
18churg-strauss syndrome10.0IL5
19onchocerciasis10.0IL5
20vasculitis10.0PRG2
21pemphigus vulgaris10.0CCL11
22hepatitis10.0CCL11
23nephrotic syndrome10.0CCL11
24gastritis10.0MUC5AC
25folliculitis10.0CCL11
26peptic ulcer10.0MUC5AC
27cholera10.0CCL11
28obesity10.0CCL11
29sjogren's syndrome10.0MUC5AC
30eosinophilic fasciitis10.0IL5
31necatoriasis10.0IL5
32glaucoma10.0MUC5AC
33colon cancer10.0MUC5AC
34atherosclerosis10.0CCL11
35pancreatic cancer10.0MUC5AC
36astrocytoma10.0PRG2
37pulmonary alveolar proteinosis10.0IL3
38aspergillosis10.0IFNG
39adenoma10.0MUC5AC
40candidiasis10.0IFNG
41periapical granuloma10.0IL4
42pleurisy10.0MUC16
43peritonitis10.0MUC16
44malaria10.0IFNG
45eosinophilia-myalgia syndrome10.0IL5
46leiomyoma10.0CCL11
47myocardial infarction10.0CCL11
48cystic fibrosis10.0CCL22, MUC5AC
49cervical cancer10.0MUC16
50eosinophilic esophagitis10.0IL5, CCL11

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Clinical Features for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Atopic Keratoconjunctivitis

Drug clinical trials:

Search ClinicalTrials for Atopic Keratoconjunctivitis

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Search CenterWatch for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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32MalaCards
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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

32
Eye

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6CCL11, PRG2
2MP:00053818.4IL2, IL4, IL5, MUC5AC, IFNG
3MP:00053976.6CCL11, CCR4, IFNG, PRG2, IGHE, IL3
4MP:00053876.3IL2, CCL11, CCR4, IFNG, PRG2, IGHE

Publications for Atopic Keratoconjunctivitis

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Genetic Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Sources:
29KEGG, 52R&D Systems, 37NCBI BioSystems Database, 12EMD Millipore, 53Reactome, 4Cell Signaling Technology, 51QIAGEN
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Pathways related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL5
29.8IL4, IL5
39.8IL4, IL2
4
Hide members
9.7IL2, IFNG
59.5IL4, IL5, CCL11
69.5IL3, IL5, IL4
7
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9.5IL2, IL5, IL3
89.5CCL22, CCL11, CCR4
99.4IL3, IL4, IL2
10
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9.3IL2, IL4, IFNG
11
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9.1IFNG, IL3, IL5, IL2
129.1IFNG, IL5, IL4, IL2
139.1IFNG, IL5, IL4, IL2
14
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9.1IL2, IL4, IL5, IFNG
159.1IL2, IL4, IL5, IFNG
169.0IL4, IL5, IGHE, CCL11
17
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8.9CCL22, CCR4, PRG2, IL5
18
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8.9PRG2, CCR4, CCL11, CCL22
19
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8.8CCL22, CCL11, CCR4, IL3, IL5
20
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8.8CCL22, CCL11, CCR4, IL3, IL5
218.7IFNG, IL3, IL5, IL4, IL2
22
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8.7IFNG, IL3, IL5, IL4, IL2
238.7IL2, IL4, IL5, IL3, IFNG
24
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8.6IL2, IL5, IL3, IGHE, IFNG
25
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8.3CCL11, IFNG, PRG2, IL3, IL5, IL4
26
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8.2CCL22, CCL11, IFNG, IL3, IL5, IL4
27
Hide members
8.1CCL22, CCL11, CCR4, IL3, IL5, IL4
28
Hide members
7.9CCL11, IFNG, IGHE, IL3, IL5, IL4

Compounds for genes affiliated with Atopic Keratoconjunctivitis

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Sources:
44Novoseek, 28IUPHAR, 2BitterDB, 59Tocris Bioscience, 11DrugBank, 49PharmGKB, 24HMDB
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Compounds related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1gm-csf44 2811.5IFNG
2hydrocortisone44 2 59 1113.4IGHE
3pge24410.2CCL11, IL2
4indomethacin44 59 28 1113.1PRG2, IL5
5ovomucoid4410.1IGHE
6unicap449.7IGHE, IL5, CCL11
7omalizumab44 1110.6IGHE, IL4, IL5
8oxatomide449.6IL5, IGHE, IL3
9salmeterol44 49 28 1112.6IL4, IL5, CCL11, IL2
10interferon gamma449.5IL4, IL2, IFNG
11c-d4t449.5IL2, IL4, IL5
12glatiramer acetate44 1110.5IL4, IL5, IFNG, IL2
13il-12449.4IL5, IL2, IL4, IFNG
14nedocromil sodium449.4IGHE, IL3, IL5, IL4
15con a449.4IL2, IL4, IFNG, IL5
16ltc4449.4PRG2, IL3, IL5, CCL11
17montelukast44 49 28 1112.4IL5, CCL11, IL4, IGHE
18azelastine44 1110.4IL3, IGHE, IL4, IL5
19itraconazole44 1110.4IL4, IL3, IGHE, IL5
20polyinosinic-polycytidylic acid449.4IL2, IL5, IFNG, IL4
21methylcellulose449.3IFNG, IL3, IL5, IL4
22vegf449.3IL5, MUC16, CCL11
23alpha-galactosylceramide449.2IFNG, IL4, IL2
24poly(i-c)449.2CCL11, IL4, IL5, IL3, IFNG
25ribavirin44 49 1111.2IL2, IL3, IFNG, IL4
26rantes449.2IFNG, IL2, IL4, IL3, CCL11
27il 10449.2IL4, IL3, IL2, IL5, IFNG
28ccl344 2810.1IFNG, CCL22, CCL11, CCR4
29pgd2449.1PRG2, IL5, CCL11, IGHE
30cyclosporin a44 28 5911.1CCL22, IL3, IGHE, IFNG, CCL11
31sodium cromoglycate449.1CCL11, IGHE, IL5
32budesonide44 49 1111.0CCL11, IFNG, IGHE, IL5, IL4
33fluticasone propionate44 49 59 1112.0IL5, IL4, IFNG, IGHE, CCL11
34ivig449.0IFNG, IGHE, IL5, IL4, IL3
35herbimycin a44 599.8IL4, IL2, IL5, IL3, IFNG, CCL11
36ionomycin448.8CCL11, IL3, IL5, IL4, IL2, IFNG
37methacholine44 119.7CCL11, PRG2, IL5, IL4, CCL22, IGHE
38tacrolimus44 49 1110.6IFNG, IL3, CCL11, CCL22, IL4, IL5
39sb 20358044 599.6IL5, MUC5AC, IL4, CCL11, IFNG, CCL22
40prednisolone44 28 1110.5CCR4, IGHE, MUC16, IL5, CCL11
41allergens448.5CCL11, IFNG, IL5, IGHE, IL4, PRG2
42genistein44 28 59 2 11 2413.5IL5, IL2, IFNG, PRG2, CCL11, IL3
43thymidine44 249.4IL4, IL2, IL5, CCL11, IL3, IFNG
44cyclophosphamide44 49 1110.4IL2, IL3, MUC16, IL4, IGHE
45tarc448.3IL4, IL5, IGHE, IFNG, CCR4, CCL11
46actinomycin d448.1IL3, CCL11, IGHE, IFNG, PRG2, IL2
47retinoic acid44 248.4IL5, IGHE, PRG2, CCL11, IFNG, IL3
48histamine44 28 249.0IGHE, IL5, CCL22, CCL11, IFNG, PRG2
49tyrosine446.7IL2, CCR4, IL4, MUC5AC, PRG2, MUC16
50dexamethasone44 49 28 119.7CCL22, IL3, MUC5AC, CCL11, IGHE, IFNG

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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16Gene Ontology
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Cellular components related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL4, IFNG, CCR4
2extracellular spaceGO:0056157.3IL2, CCL22, CCL11, IFNG, MUC16, IL3
3extracellular regionGO:0055767.2CCL22, CCL11, IFNG, PRG2, IGHE, IL3

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:05102410.0IL2, IL5
2positive regulation of MHC class II biosynthetic processGO:0453489.9IL4, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.8IL4, IFNG
4positive regulation of activated T cell proliferationGO:0421049.8IL2, IL4
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL2, IL4, IL3
6positive regulation of B cell proliferationGO:0308909.7IL5, IL4, IL2
7positive regulation of isotype switching to IgG isotypesGO:0483049.6IFNG, IL4, IL2
8response to virusGO:0096159.5CCL22, CCL11, IFNG
9defense response to protozoanGO:0428329.4IL4, IFNG
10chemotaxisGO:0069359.3IL4, CCR4, CCL11, CCL22
11inflammatory responseGO:0069549.3CCL22, CCL11, CCR4, IL5
12cell adhesionGO:0071558.3IL2, MUC5AC, MUC16, CCL11
13immune responseGO:0069557.4IL2, CCL22, CCL11, CCR4, PRG2, IGHE

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2IL2, IL4, IL5, IL3
2cytokine activityGO:0051258.4IL2, IL4, IL5, IL3, IFNG

Products for genes affiliated with Atopic Keratoconjunctivitis

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  • Antibodies
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Sources for Atopic Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet