MCID: ATP013
MIFTS: 39

Atopic Keratoconjunctivitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
31ICD10 via Orphanet, 54Orphanet, 68UMLS, 69UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 54 68

Characteristics:

Orphanet epidemiological data:

54
atopic keratoconjunctivitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 54 
Rare eye diseases


External Ids:

Orphanet54 ORPHA163934
UMLS via Orphanet69 C1274788
ICD10 via Orphanet31 H16.2

Summaries for Atopic Keratoconjunctivitis

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MalaCards based summary: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and myoclonus epilepsy, and has symptoms including Array, Array and Array. An important gene associated with Atopic Keratoconjunctivitis is IL4 (Interleukin 4), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and IL12 signaling mediated by STAT4. Affiliated tissues include eye, skin and t cells.

Related Diseases for Atopic Keratoconjunctivitis

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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 177)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.4IL4, IL5, RNASE3
2myoclonus epilepsy10.7IFNG, IL4
3eye accommodation disease10.6IFNG, IL4
4motor peripheral neuropathy10.6IFNG, IL4
5nut allergy10.6IFNG, IL4
6thelaziasis10.6IFNG, IL4
7goat milk allergy10.6IFNG, IL4
8gastroschisis abdominal wall defects, included10.6IFNG, IL5
9visual snow syndrome10.6IL2, IL4
10papillary squamous carcinoma10.6IL4, IL5
11myositis fibrosa10.6IL4, IL5
12buruli ulcer10.6IFNG, IL4
13acute conjunctivitis10.6IL4, IL5
14cholesteatoma of middle ear10.6IFNG, IL5
15bulbospinal polio10.6IFNG, IL2
16tertiary neurosyphilis10.6IFNG, IL5
17anthracosilicosis10.6IFNG, IL2
18lymphocytic colitis10.6IFNG, IL4
19graft-versus-host disease, protection against10.6IFNG, IL2
20epididymis adenocarcinoma10.6IL4, IL5
21interleukin-7 receptor alpha deficiency10.6IL2, IL4
22glucose intolerance10.6IL4, IL5
23primary orthostatic tremor10.6IFNG, IL4
24bacterial gastritis10.6IL4, IL5
25meninges hemangiopericytoma10.5IFNG, IL4
26addison's disease10.5IFNG, IL2
27opiate dependence10.5IFNG, IL5
28orbital lymphangioma10.5IFNG, IL4
29adenomatoid tumor10.5IL4, IL5
30acute interstitial pneumonia10.5CCL22, IL5
31severe nonproliferative diabetic retinopathy10.5IL3, IL5
32renal cell carcinoma 410.5IFNG, IL4
33cherry allergy10.5CCL22, IL5
34african histoplasmosis10.5IL4, IL5
35idiopathic neutropenia10.5IFNG, IL5
36scn8a encephalopathy10.5IFNG, IL4
37spermatic cord cancer10.5IL4, IL5
38congenital disorder of glycosylation, type iq10.5IL3, IL5
39atrichia with papular lesions10.5IFNG, IL4
40papillary conjunctivitis10.5IL4, RNASE3
41calcifying epithelial odontogenic tumor10.5IFNG, IL2
42orbit alveolar rhabdomyosarcoma10.5CCL22, IFNG
43multicentric castleman disease10.5IFNG, IL4
44merkel cell carcinoma10.5IL5, RNASE3
45potter's syndrome10.5IFNG, IL2
46pharyngitis10.5IL2, IL4
47philophthalmiasis10.5IL4, IL5
48toxic diffuse goiter10.5IL5, RNASE3
49stampe sorensen syndrome10.4IFNG, IL3
50malignant histiocytosis10.4IFNG, IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

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Human phenotypes related to Atopic Keratoconjunctivitis:

 54 (show all 8)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin54 Very frequent (99-80%)
2 keratoconjunctivitis sicca54 Very frequent (99-80%)
3 corneal opacity54 Very frequent (99-80%)
4 abnormality of the eyelid54 Frequent (79-30%)
5 blepharitis54 Frequent (79-30%)
6 loss of eyelashes54 Frequent (79-30%)
7 corneal neovascularization54 Frequent (79-30%)
8 chemosis54 Occasional (29-5%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Cyclosporineapproved, investigational, vet_approvedPhase 391579217-60-0, 59865-13-35284373, 6435893
Synonyms:
1c5f
1cyn
30024_FLUKA
30024_SIGMA
59865-13-3
79217-60-0
AC1L1EQW
AC1NQXJE
AC1NR4C4
AC1NUQK3
AC1NUZNC
AC1O5KOG
AC1Q2UDG
Ambap59865-13-3
Ambotz59865-13-3
Antibiotic S 7481F1
BMT-ABA-SAR-MLE-VAL-MLE-ALA-ALA-MLE-MLE-MVA
BMT-ABA-SAR-MLE-VAL-MLE-ALA-DAL-MLE-MLE-MVA
BPBio1_000496
BRD-A64290322-001-01-6
BRD-A69815203-001-04-3
BRD-K13533483-001-03-0
BSPBio_000450
BSPBio_001596
BSPBio_003186
C 3662
C05086
C1832_SIGMA
C3662_SIGMA
C62H111N11O12
CB-01-09 MMX
CHEBI:106343
CHEBI:328305
CHEBI:4031
CHEMBL160
CHEMBL386389
CHEMBL532318
CID2909
CID5280754
CID5284373
CID5458585
CID5497195
CID6435893
CSA
CYCLOSPORIN A (SEE ALSO TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A))
CYCLOSPORIN A, USP
Ciclosporin
Ciclosporin (JP15)
Ciclosporina
Ciclosporine
Ciclosporinum
Cipol N
Cipol-N
Consupren
Consupren S
CsA
CsA & IFN.alpha.
CyA
Cyclokat
Cyclosporin
Cyclosporin A
Cyclosporin A & IFN.alpha.
Cyclosporin A Implant
Cyclosporin A, Tolypocladium inflatum
Cyclosporine (USP)
Cyclosporine A
Cyclosporine [USAN]
D00184
DE-076
DivK1c_000871
EU-0100242
Equoral
GNF-Pf-2808
Gengraf
Gengraf (TN)
HMS1569G12
HMS1791P18
HMS1921L20
HMS1989P18
HMS2089A09
HMS2092F06
HMS502L13
Helv Chim Acta 60: 1568 (1977)
 
I06-0379
I06-0966
IDI1_000871
KBio1_000871
KBio2_000780
KBio2_003348
KBio2_005916
KBio3_002686
KBioGR_001898
KBioSS_000780
LMPK14000003
LS-257
LS-58836
Lopac0_000242
MLS000028376
MLS001333756
MLS002153454
MLS002207033
Mitogard
Modusik-A
MolPort-000-760-988
MolPort-005-934-008
MolPort-006-705-994
NCGC00093704-01
NCGC00093704-02
NCGC00093704-03
NCGC00093704-04
NCGC00093704-05
NCGC00093704-06
NCGC00093704-07
NCGC00093704-08
NCGC00164258-01
NCGC00164258-02
NINDS_000871
NSC290193
Neoplanta
Neoral
Neoral (TN)
NeuroSTAT
Nova-22007
OL 27-400
OL-27400
OLO-400
Papilock
Prestwick2_000435
Prestwick3_000435
Prestwick_731
Pulminiq
Ramihyphin A
Restasis
Restasis (TN)
S-Neoral
S1514_Selleck
SDZ-OXL 400
SMR000058578
SPBio_001467
SPECTRUM1502202
ST-603
Sandimmun
Sandimmun Neoral
Sandimmune
Sandimmune (TN)
Sandimmune, Gengraf, Restasis, Atopica, Sangcya, Cyclosporine
Sang-2000
Sang-35
SangCyA
Sangcya
Sigmasporin
Sigmasporin Microoral
Spectrum2_001484
Spectrum3_001593
Spectrum4_001279
Spectrum5_001628
Spectrum_000300
TRANSGENIC MODEL EVALUATION (CYCLOSPORIN A)
Vekacia
Zyclorin
cyclophorine
cyclosporin A
cyclosporine
from Tolypocladium inflatum (Trichoderma polysporin)
nchembio.184-comp6
nchembio.301-comp5
nchembio.342-comp1
2
Miconazoleapproved, investigational, vet_approvedPhase 3362422916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
3Ophthalmic SolutionsPhase 31092
4Pharmaceutical SolutionsPhase 37793
5Immunosuppressive AgentsPhase 312770
6Dermatologic AgentsPhase 35674
7Anti-Infective AgentsPhase 321402
8Antifungal AgentsPhase 33615
9Antirheumatic AgentsPhase 310627
10Calcineurin InhibitorsPhase 31597
11Tetrahydrozoline593

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic KeratoconjunctivitisCompletedNCT00884585Phase 3
2Long-term Topical Cyclosporine for Atopic KeratoconjunctivitisCompletedNCT00987467

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

36
Eye, Skin, T cells, Bone, Bone marrow

Publications for Atopic Keratoconjunctivitis

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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 85)
idTitleAuthorsYear
1
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. (28076564)
2016
2
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. (27721987)
2016
3
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. (27901637)
2016
4
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. (25682856)
2015
5
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. (25923050)
2015
6
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. (26278858)
2015
7
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. (26302769)
2015
8
Central corneal thickness in patients with atopic keratoconjunctivitis. (25240805)
2014
9
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. (24439439)
2014
10
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. (25705372)
2014
11
Functional visual acuity assessment of severe atopic keratoconjunctivitis. (25289719)
2014
12
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
13
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. (23886231)
2013
14
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
15
Atopic keratoconjunctivitis: A review. (24342754)
2013
16
Atopic keratoconjunctivitis. (23406935)
2013
17
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
18
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
19
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
20
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
21
Atopic keratoconjunctivitis: present day diagnosis. (22872669)
2012
22
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
23
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
24
Topical cyclosporine for atopic keratoconjunctivitis. (22972132)
2012
25
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. (22581322)
2012
26
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
27
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
28
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
29
Omalizumab for severe atopic keratoconjunctivitis. (22791726)
2010
30
Atopic keratoconjunctivitis and atopic dermatitis. (20720488)
2010
31
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
32
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
33
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. (20482394)
2010
34
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
35
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. (18721214)
2009
36
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
37
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
38
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
39
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. (18724148)
2008
40
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. (17620070)
2007
41
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
42
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
43
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
44
Clinical grading of atopic keratoconjunctivitis. (17873586)
2007
45
Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. (17177679)
2006
46
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
47
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. (16371796)
2006
48
Systemic tacrolimus in the treatment of severe atopic keratoconjunctivitis. (17172887)
2006
49
Chemokine receptor gene expression in giant papillae of atopic keratoconjunctivitis. (15788997)
2005
50
Atopic keratoconjunctivitis. (15245362)
2004

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 29)
idSuper pathwaysScoreTop Affiliating Genes
19.9IL4, IL5
29.8IFNG, IL2
39.8IFNG, IL2
4
Show member pathways
9.5IFNG, IL2, IL4
59.5IFNG, IL2, IL4
69.5IL3, IL4, IL5
79.4IFNG, IL2, IL3
8
Show member pathways
9.4IL2, IL3, IL5
99.4IGHE, IL4, IL5
109.2IFNG, IL2, IL4, IL5
119.2IFNG, IL2, IL4, IL5
129.2IFNG, IL2, IL4, IL5
13
Show member pathways
9.2IFNG, IL2, IL4, IL5
149.2IFNG, IL2, IL4, IL5
159.2IFNG, IL2, IL4, IL5
16
Show member pathways
9.1IFNG, IL2, IL3, IL4
179.1IFNG, IL2, IL3, IL4
18
Show member pathways
9.0IFNG, IGHE, IL2, IL4
19
Show member pathways
8.9IGHE, IL3, IL4, IL5
208.9CCL22, IFNG, IL2, IL4, IL5
21
Show member pathways
8.8IFNG, IL2, IL3, IL4, IL5
22
Show member pathways
8.8IFNG, IL2, IL3, IL4, IL5
238.8IFNG, IL2, IL3, IL4, IL5
248.7CCL22, IL2, IL3, IL4, IL5
25
Show member pathways
8.7CCL22, IL2, IL3, IL4, IL5
26
Show member pathways
8.4CCL22, IFNG, IL2, IL3, IL4, IL5
27
Show member pathways
8.4CCL22, IFNG, IL2, IL3, IL4, IL5
28
Show member pathways
8.4CCL22, IFNG, IL2, IL3, IL4, IL5
29
Show member pathways
7.5IFNG, IL2, IL3, IL4, IL5, PRG2

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:000989710.1IFNG, IGHE, IL4
2extracellular regionGO:00055767.6CCL22, IFNG, IGHE, IL2, IL3, IL5
3extracellular spaceGO:00056156.8CCL22, IFNG, IL2, IL3, IL4, IL5

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1defense response to protozoanGO:004283210.6IFNG, IL4
2extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.6IL2, IL4
3positive regulation of chemokine biosynthetic processGO:004508010.6IFNG, IL4
4positive regulation of activated T cell proliferationGO:004210410.6IL2, IL4
5positive regulation of MHC class II biosynthetic processGO:004534810.5IFNG, IL4
6innate immune response in mucosaGO:000222710.5IL4, RNASE3
7positive regulation of immunoglobulin secretionGO:005102410.4IL2, IL5
8positive regulation of B cell activationGO:005087110.4IGHE, IL4
9positive regulation of T cell differentiationGO:004558210.4IL2, IL4
10positive regulation of B cell proliferationGO:003089010.2IL2, IL4, IL5
11positive regulation of isotype switching to IgG isotypesGO:004830410.1IFNG, IL2, IL4
12positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.0IL3, IL4, IL5
13positive regulation of T cell proliferationGO:00421029.9IFNG, IL2, IL4
14positive regulation of GTPase activityGO:00435479.6CCL22, IL2, IL3, IL5
15defense response to bacteriumGO:00427429.6IFNG, IGHE, PRG2
16positive regulation of cell proliferationGO:00082849.5IFNG, IL2, IL3, IL4, IL5
17positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.4IL2, IL3, IL4
18immune responseGO:00069558.1CCL22, IGHE, IL2, IL3, IL4, IL5

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:00080839.7IL2, IL3, IL4, IL5
2cytokine activityGO:00051259.4IFNG, IL2, IL3, IL4, IL5
3Ras guanyl-nucleotide exchange factor activityGO:00050889.4IL2, IL3, IL5

Sources for Atopic Keratoconjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
27GTR
28HGMD
29HMDB
30ICD10
31ICD10 via Orphanet
32ICD9CM
33IUPHAR
34KEGG
37MedGen
39MeSH
40MESH via Orphanet
41MGI
44NCI
45NCIt
46NDF-RT
49NINDS
50Novoseek
52OMIM
53OMIM via Orphanet
57PubMed
58QIAGEN
63SNOMED-CT via Orphanet
67Tumor Gene Family of Databases
68UMLS
69UMLS via Orphanet