MCID: ATP013
MIFTS: 38

Atopic Keratoconjunctivitis malady

Eye category

Summaries for Atopic Keratoconjunctivitis

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33MalaCards
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MalaCards: Atopic Keratoconjunctivitis is related to vernal keratoconjunctivitis and atopic dermatitis. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (chemokine (C-C motif) ligand 22), and among its related pathways are Leishmaniasis and IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types. The compounds gm-csf and hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone marrow and t cells, and related mouse phenotypes are respiratory system and digestive/alimentary.

Aliases & Classifications for Atopic Keratoconjunctivitis

Sources:
49Orphanet, 61UMLS, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Eye


Characteristics (Orphanet epidemiological data):

49
atopic keratoconjunctivitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

atopic keratoconjunctivitis 49 61


External Ids:

ICD10 via Orphanet26 H16.2
SNOMED-CT via Orphanet58 403434009
UMLS via Orphanet62 C1274788

Related Diseases for Atopic Keratoconjunctivitis

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 162)
idRelated DiseaseScoreTop Affiliating Genes
1vernal keratoconjunctivitis30.6CCL11, IGHE, IL3, IL5, IL4
2atopic dermatitis30.5IL4, CCL11, CCL22
3alopecia areata30.2IFNG
4allergic conjunctivitis30.2IL4, IL5, IGHE, CCL11
5corneal disease10.1
6stevens-johnson syndrome10.1
7cicatricial pemphigoid10.1
8vernal conjunctivitis10.1
9alopecia10.1
10ocular cicatricial pemphigoid10.1
11mast syndrome10.1
12churg-strauss syndrome10.0IL5
13onchocerciasis10.0IL5
14vasculitis10.0PRG2
15pemphigus vulgaris10.0CCL11
16hepatitis10.0CCL11
17nephrotic syndrome10.0CCL11
18gastritis10.0MUC5AC
19folliculitis10.0CCL11
20peptic ulcer10.0MUC5AC
21cholera10.0CCL11
22obesity10.0CCL11
23sjogren's syndrome10.0MUC5AC
24eosinophilic fasciitis10.0IL5
25necatoriasis10.0IL5
26glaucoma10.0MUC5AC
27colon cancer10.0MUC5AC
28atherosclerosis10.0CCL11
29pancreatic cancer10.0MUC5AC
30astrocytoma10.0PRG2
31pulmonary alveolar proteinosis10.0IL3
32aspergillosis10.0IFNG
33adenoma10.0MUC5AC
34candidiasis10.0IFNG
35periapical granuloma10.0IL4
36pleurisy10.0MUC16
37peritonitis10.0MUC16
38malaria10.0IFNG
39eosinophilia-myalgia syndrome10.0IL5
40leiomyoma10.0CCL11
41myocardial infarction10.0CCL11
42conjunctivitis10.0IGHE
43cystic fibrosis10.0CCL22, MUC5AC
44cervical cancer10.0MUC16
45keratoconjunctivitis10.0IL5, CCL11
46eosinophilic esophagitis10.0IL5, CCL11
47colon adenocarcinoma10.0MUC5AC
48chronic eosinophilic pneumonia10.0IL5, CCL11
49giant papillary conjunctivitis10.0CCL11, IL5
50leprosy10.0IL2

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Clinical Features for Atopic Keratoconjunctivitis

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Atopic Keratoconjunctivitis

Drug clinical trials:

Search ClinicalTrials for Atopic Keratoconjunctivitis

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Search CenterWatch for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

33
Bone marrow, T cells

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053889.6CCL11, PRG2
2MP:00053818.4IL2, IL4, IL5, MUC5AC, IFNG
3MP:00053976.6CCL11, CCR4, IFNG, PRG2, IGHE, IL3
4MP:00053876.3IL2, CCL11, CCR4, IFNG, PRG2, IGHE

Publications for Atopic Keratoconjunctivitis

Sources:
51PubMed
See all sources

Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 81)
idTitleAuthorsYear
1
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
2
Atopic keratoconjunctivitis: A review. (24342754)
2013
3
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. (23886231)
2013
4
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
5
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
6
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
7
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
8
Topical cyclosporine for atopic keratoconjunctivitis. (22972132)
2012
9
Atopic keratoconjunctivitis: present day diagnosis. (22872669)
2012
10
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. (22581322)
2012
11
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
12
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
13
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
14
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
15
Omalizumab for severe atopic keratoconjunctivitis. (22791726)
2010
16
Atopic dermatitis and keratoconjunctivitis. (20670816)
2010
17
Atopic keratoconjunctivitis and atopic dermatitis. (20720488)
2010
18
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. (18721214)
2009
19
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
20
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
21
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
22
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
23
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
24
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
25
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. (17620070)
2007
26
Chemokine receptor gene expression in giant papillae of atopic keratoconjunctivitis. (15788997)
2005
27
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
28
A comparative evaluation of the efficacy of intraoperative mitomycin C use after the excision of cobblestone-like papillae in severe atopic and vernal keratoconjunctivitis. (15097124)
2004
29
No apparent association between periocular and ocular microcolonization and the degree of inflammation in patients with atopic keratoconjunctivitis. (15144463)
2004
30
Atopic keratoconjunctivitis. (15245362)
2004
31
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
32
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
33
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
34
Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis. (11914228)
2002
35
Similar T helper Th2-like cytokine mRNA expression in vernal keratoconjunctivitis regardless of atopic constitution. (11972484)
2002
36
Tear levels of interferon-gamma, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. (10606937)
2000
37
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
38
Atopic and vernal keratoconjunctivitis: a model for studying atopic disease. (10374055)
1999
39
Atopic keratoconjunctivitis (AKC). (10337422)
1999
40
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
41
A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. (9754182)
1998
42
Atopic keratoconjunctivitis. (9269601)
1997
43
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
44
IgE, IgE receptors, and other immunocytochemical markers in atopic and nonatopic patients with vernal keratoconjunctivitis. (7777271)
1995
45
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
46
Mast cell hyperplasia in atopic keratoconjunctivitis. An immunohistochemical study. (1800175)
1991
47
Immunopathology of atopic keratoconjunctivitis. (1923355)
1991
48
Late complications of combined radial and transverse keratotomy after penetrating keratoplasty associated with atopic keratoconjunctivitis. (2484950)
1989
49
Atopic keratoconjunctivitis. (13411162)
1957
50
Atopic keratoconjunctivitis. (13065376)
1953

Genetic Variations for Atopic Keratoconjunctivitis

Expression for genes affiliated with Atopic Keratoconjunctivitis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

Sources:
30KEGG, 53R&D Systems, 38NCBI BioSystems Database, 12EMD Millipore, 54Reactome, 4Cell Signaling Technology, 52QIAGEN
See all sources

Pathways related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 28)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.2IL5
29.8IL4, IL5
39.8IL4, IL2
4
Hide members
9.7IL2, IFNG
59.5IL4, IL5, CCL11
69.5IL3, IL5, IL4
7
Hide members
9.5IL2, IL5, IL3
89.5CCL22, CCL11, CCR4
99.4IL3, IL4, IL2
10
Hide members
9.3IL2, IL4, IFNG
11
Hide members
9.1IFNG, IL3, IL5, IL2
129.1IFNG, IL5, IL4, IL2
139.1IFNG, IL5, IL4, IL2
14
Hide members
9.1IL2, IL4, IL5, IFNG
159.1IL2, IL4, IL5, IFNG
169.0IL4, IL5, IGHE, CCL11
17
Hide members
8.9CCL22, CCR4, PRG2, IL5
18
Hide members
8.9PRG2, CCR4, CCL11, CCL22
19
Hide members
8.8CCL22, CCL11, CCR4, IL3, IL5
20
Hide members
8.8CCL22, CCL11, CCR4, IL3, IL5
218.7IFNG, IL3, IL5, IL4, IL2
22
Hide members
8.7IFNG, IL3, IL5, IL4, IL2
238.7IL2, IL4, IL5, IL3, IFNG
24
Hide members
8.6IL2, IL5, IL3, IGHE, IFNG
25
Hide members
8.3CCL11, IFNG, PRG2, IL3, IL5, IL4
26
Hide members
8.2CCL22, CCL11, IFNG, IL3, IL5, IL4
27
Hide members
8.1CCL22, CCL11, CCR4, IL3, IL5, IL4
28
Hide members
7.9CCL11, IFNG, IGHE, IL3, IL5, IL4

Compounds for genes affiliated with Atopic Keratoconjunctivitis

Sources:
45Novoseek, 29IUPHAR, 2BitterDB, 60Tocris Bioscience, 11DrugBank, 50PharmGKB, 24HMDB
See all sources

Compounds related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 131)
idCompoundScoreTop Affiliating Genes
1gm-csf45 2911.5IFNG
2hydrocortisone45 2 60 1113.4IGHE
3pge24510.2CCL11, IL2
4indomethacin45 60 29 1113.1PRG2, IL5
5ovomucoid4510.1IGHE
6unicap459.7IGHE, IL5, CCL11
7omalizumab45 1110.6IGHE, IL4, IL5
8oxatomide459.6IL5, IGHE, IL3
9salmeterol45 50 29 1112.6IL4, IL5, CCL11, IL2
10interferon gamma459.5IL4, IL2, IFNG
11c-d4t459.5IL2, IL4, IL5
12glatiramer acetate45 1110.5IL4, IL5, IFNG, IL2
13il-12459.4IL5, IL2, IL4, IFNG
14nedocromil sodium459.4IGHE, IL3, IL5, IL4
15con a459.4IL2, IL4, IFNG, IL5
16ltc4459.4PRG2, IL3, IL5, CCL11
17montelukast45 50 29 1112.4IL5, CCL11, IL4, IGHE
18azelastine45 1110.4IL3, IGHE, IL4, IL5
19itraconazole45 1110.4IL4, IL3, IGHE, IL5
20polyinosinic-polycytidylic acid459.4IL2, IL5, IFNG, IL4
21methylcellulose459.3IFNG, IL3, IL5, IL4
22vegf459.3IL5, MUC16, CCL11
23alpha-galactosylceramide459.2IFNG, IL4, IL2
24poly(i-c)459.2CCL11, IL4, IL5, IL3, IFNG
25ribavirin45 50 1111.2IL2, IL3, IFNG, IL4
26rantes459.2IFNG, IL2, IL4, IL3, CCL11
27il 10459.2IL4, IL3, IL2, IL5, IFNG
28ccl345 2910.1IFNG, CCL22, CCL11, CCR4
29pgd2459.1PRG2, IL5, CCL11, IGHE
30cyclosporin a45 29 6011.1CCL22, IL3, IGHE, IFNG, CCL11
31sodium cromoglycate459.1CCL11, IGHE, IL5
32budesonide45 50 1111.0CCL11, IFNG, IGHE, IL5, IL4
33fluticasone propionate45 50 60 1112.0IL5, IL4, IFNG, IGHE, CCL11
34ivig459.0IFNG, IGHE, IL5, IL4, IL3
35herbimycin a45 609.8IL4, IL2, IL5, IL3, IFNG, CCL11
36ionomycin458.8CCL11, IL3, IL5, IL4, IL2, IFNG
37methacholine45 119.7CCL11, PRG2, IL5, IL4, CCL22, IGHE
38tacrolimus45 50 1110.6IFNG, IL3, CCL11, CCL22, IL4, IL5
39sb 20358045 609.6IL5, MUC5AC, IL4, CCL11, IFNG, CCL22
40prednisolone45 29 1110.5CCR4, IGHE, MUC16, IL5, CCL11
41allergens458.5CCL11, IFNG, IL5, IGHE, IL4, PRG2
42genistein45 29 60 2 11 2413.5IL5, IL2, IFNG, PRG2, CCL11, IL3
43thymidine45 249.4IL4, IL2, IL5, CCL11, IL3, IFNG
44cyclophosphamide45 50 1110.4IL2, IL3, MUC16, IL4, IGHE
45tarc458.3IL4, IL5, IGHE, IFNG, CCR4, CCL11
46actinomycin d458.1IL3, CCL11, IGHE, IFNG, PRG2, IL2
47retinoic acid45 248.4IL5, IGHE, PRG2, CCL11, IFNG, IL3
48histamine45 29 249.0IGHE, IL5, CCL22, CCL11, IFNG, PRG2
49tyrosine456.7IL2, CCR4, IL4, MUC5AC, PRG2, MUC16
50dexamethasone45 50 29 119.7CCL22, IL3, MUC5AC, CCL11, IGHE, IFNG

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

Sources:
16Gene Ontology
See all sources

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL4, IFNG, CCR4
2extracellular spaceGO:0056157.3IL2, CCL22, CCL11, IFNG, MUC16, IL3
3extracellular regionGO:0055767.2CCL22, CCL11, IFNG, PRG2, IGHE, IL3

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:05102410.0IL2, IL5
2positive regulation of MHC class II biosynthetic processGO:0453489.9IL4, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.8IL4, IFNG
4positive regulation of activated T cell proliferationGO:0421049.8IL2, IL4
5positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL2, IL4, IL3
6positive regulation of B cell proliferationGO:0308909.7IL5, IL4, IL2
7positive regulation of isotype switching to IgG isotypesGO:0483049.6IFNG, IL4, IL2
8response to virusGO:0096159.5CCL22, CCL11, IFNG
9defense response to protozoanGO:0428329.4IL4, IFNG
10chemotaxisGO:0069359.3IL4, CCR4, CCL11, CCL22
11inflammatory responseGO:0069549.3CCL22, CCL11, CCR4, IL5
12cell adhesionGO:0071558.3IL2, MUC5AC, MUC16, CCL11
13immune responseGO:0069557.4IL2, CCL22, CCL11, CCR4, PRG2, IGHE

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1growth factor activityGO:0080839.2IL2, IL4, IL5, IL3
2cytokine activityGO:0051258.4IL2, IL4, IL5, IL3, IFNG

Products for genes affiliated with Atopic Keratoconjunctivitis

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopic Keratoconjunctivitis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet