MCID: ATP013
MIFTS: 46

Atopic Keratoconjunctivitis malady

Eye diseases, Rare diseases categories
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Summaries for Atopic Keratoconjunctivitis

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33MalaCards
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MalaCards: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and corneal ulcer. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (chemokine (C-C motif) ligand 22), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Jak/Stat Pathway. The compounds salmeterol and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Atopic Keratoconjunctivitis

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49Orphanet, 62UMLS, 26ICD10 via Orphanet, 59SNOMED-CT via Orphanet, 63UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 49 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

49
atopic keratoconjunctivitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

atopic keratoconjunctivitis 49 62


External Ids:

ICD10 via Orphanet26 H16.2
SNOMED-CT via Orphanet59 403434009
UMLS via Orphanet63 C1274788

Related Diseases for Atopic Keratoconjunctivitis

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17GeneCards, 18GeneDecks
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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.7CCL11, IL5
2corneal ulcer30.7MUC5AC, PRG2, CCL11
3atopic dermatitis30.5IL4, CCL11, CCL22
4dermatitis30.4IL4, IFNG, CCL11, CCL22, CCR4, IGHE
5conjunctivitis30.4IGHE
6vernal keratoconjunctivitis30.4IGHE, CCL11, IL4, IL5, IL3
7allergic conjunctivitis30.2IGHE, CCL11, IL4, IL5
8corneal disease10.1
9cicatricial pemphigoid10.1
10stevens-johnson syndrome10.1
11alopecia10.1
12alopecia areata10.1
13herpes simplex10.1
14influenza10.1
15keratitis10.1
16keratoconus10.1
17ocular cicatricial pemphigoid10.1
18folliculitis10.1CCL11
19eosinophilic fasciitis10.1IL5
20eosinophilia-myalgia syndrome10.1IL5
21periapical granuloma10.1IL4
22malaria10.1IFNG
23aspergillosis10.1IFNG
24eczema herpeticum10.1IGHE
25allergic contact dermatitis10.1CCR4, IL5
26pleurisy10.1MUC16
27chronic eosinophilic pneumonia10.1CCL11, IL5
28giant papillary conjunctivitis10.1IL5, CCL11
29eosinophilic esophagitis10.1CCL11, IL5
30hypereosinophilic syndrome10.1IL3, IL5
31strongyloidiasis10.1IL5, IGHE
32leprosy10.1IL2
33dermatographia10.1IGHE, PRG2
34helminthiasis10.1IGHE, IL5
35pulmonary fibrosis10.1PRG2, CCR4, CCL22
36paragonimiasis10.1IGHE, IL5
37eye disease10.1MUC5AC, CCL11
38pneumonia10.1CCL22, CCL11, IL5
39filariasis10.1IGHE, IL5
40esophagitis10.1PRG2, CCL11, IL5
41mastocytosis10.1IGHE, IL5
42angioedema10.0IL5, IGHE
43immunodeficiency with hyper igm type 110.0IGHE, IL4
44cystadenocarcinoma10.0MUC5AC, MUC16
45visceral leishmaniasis10.0IFNG, IL4
46pulmonary disease, chronic obstructive10.0CCL11, CCR4, MUC5AC
47cervical adenocarcinoma10.0MUC5AC, MUC16
48kimura disease10.0IGHE, PRG2, IL5
49idiopathic pulmonary fibrosis10.0CCR4, CCL22, IFNG
50contact dermatitis10.0IGHE, CCR4, IL5

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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42NIH Clinical Center, 6ClinicalTrials
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Drug clinical trials:

Search ClinicalTrials for Atopic Keratoconjunctivitis

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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33MalaCards
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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

33
Eye, Bone marrow, Bone

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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37MGI
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MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1IL3, IL5, IL2, IFNG
2MP:00053818.3MUC5AC, IFNG, IL4, IL2, IL5
3MP:00053887.5PRG2, CCR4, CCL11, IFNG, IL4, IL2
4MP:00053767.0IGHE, MUC5AC, IFNG, IL4, IL2, IL5
5MP:00053976.6IGHE, PRG2, CCR4, CCL11, IFNG, IL4
6MP:00053876.1IL3, IGHE, MUC5AC, PRG2, CCR4, CCL11

Publications for Atopic Keratoconjunctivitis

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52PubMed
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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
2
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
3
Atopic keratoconjunctivitis: A review. (24342754)
2013
4
Atopic keratoconjunctivitis. (23406935)
2013
5
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
6
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
7
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
8
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
9
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
10
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
11
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
12
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
13
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
14
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
15
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
16
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. (20482394)
2010
17
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
18
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
19
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
20
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
21
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
22
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
23
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
24
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
25
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. (16371796)
2006
26
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
27
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis. (15548799)
2004
28
A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. (15019322)
2004
29
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
30
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
31
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
32
Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis. (11914228)
2002
33
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
34
Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)
1999
35
Analysis of tears in patients with atopic keratoconjunctivitis, using flow cytometry. (9483587)
1998
36
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
37
A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. (9754182)
1998
38
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry. (9441704)
1997
39
Atopic keratoconjunctivitis. (9269601)
1997
40
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
41
Penetrating keratoplasty in atopic keratoconjunctivitis. (8575184)
1995
42
Atopic keratoconjunctivitis. (22823113)
1994
43
Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with long-term topical cyclosporin A. (7842716)
1994
44
Atopic keratoconjunctivitis (AKC). (8344185)
1993
45
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
46
Atopic keratoconjunctivitis. (1976238)
1990
47
Plasmapheresis treatment in patients with severe atopic keratoconjunctivitis. (3174011)
1988
48
Atopic keratoconjunctivitis. (13411162)
1957
49
Atopic keratoconjunctivitis. (13065376)
1953
50
Atopic keratoconjunctivitis. (13102561)
1952

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Sources:
50PathCards, 54R&D Systems, 5Cell Signaling Technology, 60Thomson Reuters, 38NCBI BioSystems Database, 12EMD Millipore, 30KEGG, 55Reactome, 53QIAGEN
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Pathways related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, IL4
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.7IFNG, IL4
39.7IFNG, IL2
49.7IFNG, IL2
5
Show member pathways
9.7IL2, IFNG
69.5IL5, IL4, CCL11
79.5IL4, IL5, IL3
8
Show member pathways
9.5IL3, IL5, IL2
9
Show member pathways
9.5CCR4, CCL22, CCL11
10
Show member pathways
9.5CCL11, CCL22, CCR4
119.4IL3, IL2, IL4
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4IL4, IFNG, CCL11
139.3IFNG, IL4, IL2
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3IL2, IL4, IFNG
15
Show member pathways
9.3IL2, IL4, IFNG
16
Show member pathways
9.1IFNG, IL2, IL5, IL3
17
Show member pathways
9.1IFNG, IL4, IL2, IL5
189.1IFNG, IL4, IL2, IL5
199.1IFNG, IL4, IL2, IL5
209.1IFNG, IL4, IL2, IL5
219.1IL5, IL2, IL4, IFNG
22
Show member pathways
BCR signaling pathway38
TCR Signaling Pathway38
9.1IFNG, IL4, IL2, IL5
23
Show member pathways
Immune response CD16 signaling in NK cells60
9.0IL3, IL2, IL4, IFNG
24
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.0IL4, CCL11, IGHE
25
Show member pathways
8.9PRG2, CCR4, CCL22, CCL11
268.7IFNG, IL4, IL2, IL5, IL3
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway38
8.7IFNG, IL4, IL2, IL5, IL3
28
Show member pathways
Type III interferon signaling38
8.7IL3, IL5, IL2, IL4, IFNG
298.7IGHE, CCL11, IL4, IL5
30
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells38
8.7IGHE, IL4, IL5, IL3
31
Show member pathways
8.2CCL22, CCL11, IFNG, IL4, IL2, IL5
32
Show member pathways
8.1IL5, IL2, IL4, CCL11, CCL22, CCR4
33
Show member pathways
8.1CCR4, CCL22, CCL11, IL4, IL2, IL5
34
Show member pathways
7.9IL3, IL5, IL2, IL4, IFNG, CCL11
35
Show member pathways
7.7CCR4, CCL22, CCL11, IFNG, IL4, IL2
36
Show member pathways
7.6PRG2, CCR4, CCL22, CCL11, IL4, IL2

Compounds for genes affiliated with Atopic Keratoconjunctivitis

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Sources:
45Novoseek, 51PharmGKB, 29IUPHAR, 11DrugBank, 61Tocris Bioscience, 24HMDB, 3BitterDB
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Compounds related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1salmeterol45 51 29 1112.6IL4, IL5, IL2, CCL11
2interferon gamma459.5IL4, IL2, IFNG
3glatiramer acetate45 1110.4IL4, IFNG, IL2, IL5
4il-12459.4IFNG, IL5, IL2, IL4
5con a459.4IL2, IL4, IFNG, IL5
6ltc4459.4CCL11, IL3, PRG2, IL5
7rolipram45 61 2911.4CCL11, IFNG, IL4, IL5
8polyinosinic-polycytidylic acid459.4IL5, IL4, IL2, IFNG
9unicap459.3IGHE, IL5, CCL11
10omalizumab45 1110.3IL4, IGHE, IL5
11methylcellulose459.3IFNG, IL4, IL5, IL3
12oxatomide459.3IGHE, IL5, IL3
13poly(i-c)459.2CCL11, IL4, IFNG, IL5, IL3
14gm-csf45 2910.2IL3, IL4, IL2, IL5, IFNG
15il 10459.1IL3, IL4, IFNG, IL2, IL5
16nedocromil sodium459.1IGHE, IL4, IL5, IL3
17ribavirin45 51 1111.1IL2, IL4, IFNG, IL3
18azelastine45 1110.1IL5, IGHE, IL4, IL3
19itraconazole45 1110.1IGHE, IL4, IL5, IL3
20montelukast45 51 29 1112.1IGHE, CCL11, IL4, IL5
21ccl345 2910.0IFNG, CCR4, CCL22, CCL11
22ovomucoid458.9IGHE, IL5, IL4
23melphalan45 51 1110.9IFNG, MUC16, IL4, IL3
24herbimycin a45 619.9IL4, IL3, IL5, IFNG, CCL11, IL2
25ionomycin458.8IFNG, CCL11, IL3, IL5, IL4, IL2
26pgd2458.8CCL11, PRG2, IGHE, IL5
27budesonide45 51 1110.7IL5, IL4, CCL11, IFNG, IGHE
28fluticasone propionate45 51 61 1111.7IL4, CCL11, IGHE, IFNG, IL5
29ivig458.7IGHE, IFNG, IL5, IL3, IL4
30tacrolimus45 51 1110.6IL4, IL3, IL2, CCL22, IL5, IFNG
31sb 20358045 619.6MUC5AC, CCL11, IL5, IL4, IFNG, CCL22
32thymidine45 249.6IL5, IL2, CCL11, IFNG, IL4, IL3
33genistein45 29 61 3 24 1113.6PRG2, IL3, CCL11, IFNG, IL2, IL5
34methacholine45 51 1110.4IL5, IL4, CCL11, CCL22, PRG2, IGHE
35cyclophosphamide45 51 1110.4IL4, IL2, MUC16, IL3, IGHE
36hydrocortisone45 3 61 1111.3IGHE, IFNG, IL4, IL5, IL3, IL2
37pge2458.3IL4, IL5, IL2, MUC5AC, CCL22, CCL11
38allergens458.2IFNG, PRG2, IL5, IL4, IGHE, CCL11
39rantes458.2IL5, IL2, CCL22, IFNG, CCL11, CCR4
40tarc458.0CCL22, IFNG, IL5, IL4, CCL11, CCR4
41indomethacin45 29 61 1110.8IFNG, IL4, IGHE, PRG2, CCL11, IL2
42actinomycin d457.8IFNG, IL4, IL3, IL2, CCL11, PRG2
43cyclosporin a45 29 619.8IFNG, IL2, IL5, IL3, CCL22, IGHE
44prednisolone45 29 119.7IFNG, CCR4, IL2, IL5, CCL11, IGHE
45vegf457.7CCL11, IL5, IL4, IFNG, MUC16, IL2
46cycloheximide457.6IL3, IL2, IL4, IFNG, IGHE, IL5
47retinoic acid45 248.1CCL11, CCR4, PRG2, IL3, MUC5AC, IGHE
48tyrosine457.1CCR4, MUC16, IL5, IL2, IL4, CCL11
49histamine45 29 248.7CCL22, CCL11, IL3, IL5, IL2, IGHE
50dexamethasone45 51 29 119.7IL5, IL4, IFNG, MUC5AC, CCL11, CCL22

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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16Gene Ontology
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Cellular components related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL4, IFNG, CCR4
2extracellular spaceGO:0056157.6IL3, MUC16, CCL22, CCL11, IFNG, IL4
3extracellular regionGO:0055766.9IGHE, PRG2, CCL22, CCL11, IFNG, IL2

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:05102410.0IL5, IL2
2positive regulation of MHC class II biosynthetic processGO:0453489.9IL4, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.9IFNG, IL4
4defense response to protozoanGO:0428329.8IFNG, IL4
5positive regulation of activated T cell proliferationGO:0421049.8IL2, IL4
6positive regulation of B cell proliferationGO:0308909.7IL4, IL2, IL5
7positive regulation of T cell proliferationGO:0421029.7IL4, IFNG
8response to radiationGO:0093149.7CCL11, CCR4
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL4, IL2, IL3
10response to virusGO:0096159.6IFNG, CCL11, CCL22
11positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IL4, IFNG
12extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5IL2, IL4
13cell-cell signalingGO:0072679.4CCL22, IL2, IL3
14inflammatory responseGO:0069549.4CCR4, CCL22, CCL11, IL5
15chemotaxisGO:0069359.4IL4, CCL11, CCL22, CCR4
16immune responseGO:0069557.1IL3, IGHE, PRG2, CCR4, CCL22, CCL11

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.9CCL11, CCL22
2growth factor activityGO:0080838.9IL4, IL2, IL5, IL3
3cytokine activityGO:0051258.6IL3, IL5, IL2, IL4, IFNG

Products for genes affiliated with Atopic Keratoconjunctivitis

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  • Antibodies
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Sources for Atopic Keratoconjunctivitis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet