MCID: ATP013
MIFTS: 34

Atopic Keratoconjunctivitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
52Orphanet, 66UMLS, 29ICD10 via Orphanet, 67UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 52 66

Characteristics:

Orphanet epidemiological data:

52
atopic keratoconjunctivitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 52 
Rare eye diseases


External Ids:

Orphanet52 ORPHA163934
ICD10 via Orphanet29 H16.2
UMLS via Orphanet67 C1274788

Summaries for Atopic Keratoconjunctivitis

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MalaCards based summary: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and myoclonus epilepsy. An important gene associated with Atopic Keratoconjunctivitis is IL4 (Interleukin 4), and among its related pathways are Immune response_MIF-mediated glucocorticoid regulation and IL12 signaling mediated by STAT4. Affiliated tissues include eye, t cells and bone.

Related Diseases for Atopic Keratoconjunctivitis

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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 181)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.6IL4, IL5, RNASE3
2myoclonus epilepsy10.8IFNG, IL4
3eye accommodation disease10.7IFNG, IL4
4motor peripheral neuropathy10.7IFNG, IL4
5nut allergy10.7IFNG, IL4
6thelaziasis10.7IFNG, IL4
7visual snow syndrome10.7IL2, IL4
8goat milk allergy10.7IFNG, IL4
9bulbospinal polio10.7IFNG, IL2
10anthracosilicosis10.7IFNG, IL2
11buruli ulcer10.7IFNG, IL4
12graft-versus-host disease, protection against10.7IFNG, IL2
13gastroschisis abdominal wall defects, included10.7IFNG, IL5
14interleukin-7 receptor alpha deficiency10.7IL2, IL4
15lymphocytic colitis10.7IFNG, IL4
16papillary squamous carcinoma10.7IL4, IL5
17myositis fibrosa10.7IL4, IL5
18primary orthostatic tremor10.7IFNG, IL4
19acute conjunctivitis10.7IL4, IL5
20addison's disease10.7IFNG, IL2
21cholesteatoma of middle ear10.7IFNG, IL5
22tertiary neurosyphilis10.7IFNG, IL5
23epididymis adenocarcinoma10.6IL4, IL5
24glucose intolerance10.6IL4, IL5
25meninges hemangiopericytoma10.6IFNG, IL4
26bacterial gastritis10.6IL4, IL5
27amyotrophic lateral sclerosis type 410.6IFNG, IL2
28orbital lymphangioma10.6IFNG, IL4
29opiate dependence10.6IFNG, IL5
30renal cell carcinoma 410.6IFNG, IL4
31calcifying epithelial odontogenic tumor10.6IFNG, IL2
32adenomatoid tumor10.6IL4, IL5
33scn8a encephalopathy10.6IFNG, IL4
34atrichia with papular lesions10.6IFNG, IL4
35potter's syndrome10.6IFNG, IL2
36african histoplasmosis10.6IL4, IL5
37pharyngitis10.6IL2, IL4
38idiopathic neutropenia10.6IFNG, IL5
39spermatic cord cancer10.6IL4, IL5
40acute interstitial pneumonia10.6CCL22, IL5
41multicentric castleman disease10.6IFNG, IL4
42cherry allergy10.5CCL22, IL5
43severe nonproliferative diabetic retinopathy10.5IL3, IL5
44orbit alveolar rhabdomyosarcoma10.5CCL22, IFNG
45malignant histiocytosis10.5IFNG, IL4
46philophthalmiasis10.5IL4, IL5
47congenital disorder of glycosylation, type iq10.5IL3, IL5
48papillary conjunctivitis10.5IL4, RNASE3
49bolivian hemorrhagic fever10.5IFNG, IL2
50stampe sorensen syndrome10.5IFNG, IL3

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
MiconazolePhase 3357322916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Micantin (nitrate)
Miconasil Nitrate
 
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic KeratoconjunctivitisCompletedNCT00884585Phase 3
2Long-term Topical Cyclosporine for Atopic KeratoconjunctivitisCompletedNCT00987467

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

34
Eye, T cells, Bone, Bone marrow

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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Publications for Atopic Keratoconjunctivitis

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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. (25682856)
2015
2
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. (25923050)
2015
3
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. (26278858)
2015
4
Central corneal thickness in patients with atopic keratoconjunctivitis. (25240805)
2014
5
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. (24439439)
2014
6
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. (25705372)
2014
7
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
8
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. (23886231)
2013
9
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
10
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
11
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
12
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
13
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
14
Atopic keratoconjunctivitis: present day diagnosis. (22872669)
2012
15
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
16
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
17
Omalizumab for severe atopic keratoconjunctivitis. (22791726)
2010
18
Atopic keratoconjunctivitis and atopic dermatitis. (20720488)
2010
19
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
20
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
21
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. (18721214)
2009
22
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
23
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
24
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. (17620070)
2007
25
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
26
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
27
Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. (17177679)
2006
28
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
29
Atopic keratoconjunctivitis. (15245362)
2004
30
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
31
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
32
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
33
Tear levels of interferon-gamma, interleukin (IL) -2, IL-4 and IL-5 in patients with vernal keratoconjunctivitis, atopic keratoconjunctivitis and allergic conjunctivitis. (10606937)
2000
34
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
35
Bilateral keratoconus associated with Hashimoto's disease, alopecia areata and atopic keratoconjunctivitis. (10435426)
1999
36
Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)
1999
37
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
38
Analysis of tears in patients with atopic keratoconjunctivitis, using flow cytometry. (9483587)
1998
39
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
40
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry. (9441704)
1997
41
Penetrating keratoplasty in atopic keratoconjunctivitis. (8575184)
1995
42
Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with long-term topical cyclosporin A. (7842716)
1994
43
Atopic keratoconjunctivitis. (22823113)
1994
44
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
45
Atopic keratoconjunctivitis. (1976238)
1990
46
Late complications of combined radial and transverse keratotomy after penetrating keratoplasty associated with atopic keratoconjunctivitis. (2484950)
1989
47
Clinical features and diagnosis of adult atopic keratoconjunctivitis and the effect of treatment with sodium cromoglycate. (6788069)
1981
48
Atopic keratoconjunctivitis. (13411162)
1957
49
Atopic keratoconjunctivitis. (13065376)
1953
50
Atopic keratoconjunctivitis. (13102561)
1952

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 30)
idSuper pathwaysScoreTop Affiliating Genes
19.9IFNG, IL2
29.9IFNG, IL2
39.8IL4, IL5
4
Show member pathways
9.6IFNG, IL2, IL4
59.6IFNG, IL2, IL4
69.4IFNG, IL2, IL3
79.4IL3, IL4, IL5
8
Show member pathways
9.4IL2, IL3, IL5
9
Show member pathways
9.2IFNG, IL2, IL4, IL5
109.2IFNG, IL2, IL4, IL5
119.2IFNG, IL2, IL4, IL5
129.2IFNG, IL2, IL4, IL5
139.2IFNG, IL2, IL4, IL5
149.2IFNG, IL2, IL4, IL5
15
Show member pathways
9.2IFNG, IL2, IL3, IL4
169.2IFNG, IL2, IL3, IL4
179.0IGHE, IL4, IL5
188.9CCL22, IFNG, IL2, IL4, IL5
19
Show member pathways
8.8IFNG, IL2, IL3, IL4, IL5
20
Show member pathways
8.8IFNG, IL2, IL3, IL4, IL5
21
Show member pathways
8.8IFNG, IL2, IL3, IL4, IL5
228.8IFNG, IL2, IL3, IL4, IL5
23
Show member pathways
8.7IFNG, IGHE, IL2, IL4
24
Show member pathways
8.7CCL22, IL2, IL3, IL4, IL5
258.7CCL22, IL2, IL3, IL4, IL5
26
Show member pathways
8.6IGHE, IL3, IL4, IL5
27
Show member pathways
8.4CCL22, IFNG, IL2, IL3, IL4, IL5
28
Show member pathways
8.4CCL22, IFNG, IL2, IL3, IL4, IL5
29
Show member pathways
8.4CCL22, IFNG, IL2, IL3, IL4, IL5
30
Show member pathways
7.8IFNG, IL2, IL3, IL4, IL5, PRG2

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.4IFNG, IGHE, IL4
2extracellular spaceGO:00056156.8CCL22, IFNG, IL2, IL3, IL4, IL5
3extracellular regionGO:00055766.6CCL22, IFNG, IGHE, IL2, IL3, IL5

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 18)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of chemokine biosynthetic processGO:004508010.5IFNG, IL4
2positive regulation of MHC class II biosynthetic processGO:004534810.5IFNG, IL4
3positive regulation of activated T cell proliferationGO:004210410.5IL2, IL4
4defense response to protozoanGO:004283210.5IFNG, IL4
5positive regulation of immunoglobulin secretionGO:005102410.5IL2, IL5
6positive regulation of T cell differentiationGO:004558210.5IL2, IL4
7extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.4IL2, IL4
8positive regulation of isotype switching to IgG isotypesGO:004830410.2IFNG, IL2, IL4
9innate immune response in mucosaGO:000222710.2IL4, RNASE3
10positive regulation of B cell proliferationGO:003089010.1IL2, IL4, IL5
11positive regulation of B cell activationGO:005087110.0IGHE, IL4
12positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.0IL2, IL3, IL4
13positive regulation of peptidyl-tyrosine phosphorylationGO:005073110.0IL3, IL4, IL5
14positive regulation of T cell proliferationGO:00421029.8IFNG, IL2, IL4
15defense response to bacteriumGO:00427429.3IFNG, IGHE, PRG2
16positive regulation of cell proliferationGO:00082848.8IFNG, IL2, IL3, IL4, IL5
17positive regulation of GTPase activityGO:00435478.7CCL22, IL2, IL3, IL5
18immune responseGO:00069557.4CCL22, IGHE, IL2, IL3, IL4, IL5

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1Ras guanyl-nucleotide exchange factor activityGO:00050889.4IL2, IL3, IL5
2growth factor activityGO:00080838.8IL2, IL3, IL4, IL5
3cytokine activityGO:00051258.7IFNG, IL2, IL3, IL4, IL5

Sources for Atopic Keratoconjunctivitis

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2CDC
6CNVD
10DGIdb
15ExPASy
16FDA
17FMA
25GTR
26HGMD
27HMDB
28ICD10
29ICD10 via Orphanet
30ICD9CM
31IUPHAR
32KEGG
35MedGen
37MeSH
38MESH via Orphanet
39MGI
42NCI
43NCIt
44NDF-RT
47NINDS
48Novoseek
50OMIM
51OMIM via Orphanet
55PubMed
56QIAGEN
61SNOMED-CT via Orphanet
65Tumor Gene Family of Databases
66UMLS
67UMLS via Orphanet