MCID: ATP013
MIFTS: 46

Atopic Keratoconjunctivitis malady

Eye diseases, Rare diseases categories

Summaries for Atopic Keratoconjunctivitis

About this section
Sources:
34MalaCards
See all sources

Fully expand this MalaCard

Download this MalaCard
MalaCards: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and corneal ulcer. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (chemokine (C-C motif) ligand 22), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Jak/Stat Pathway. The compounds salmeterol and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Atopic Keratoconjunctivitis

About this section
Sources:
50Orphanet, 63UMLS, 27ICD10 via Orphanet, 60SNOMED-CT via Orphanet, 64UMLS via Orphanet
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 50 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

50
atopic keratoconjunctivitis:
Prevalence: 1-5/10000


Aliases & Descriptions:

atopic keratoconjunctivitis 50 63


External Ids:

ICD10 via Orphanet27 H16.2
SNOMED-CT via Orphanet60 403434009
UMLS via Orphanet64 C1274788

Related Diseases for Atopic Keratoconjunctivitis

About this section
Sources:
18GeneCards, 19GeneDecks
See all sources

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 127)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis31.7CCL11, IL5
2corneal ulcer30.7MUC5AC, PRG2, CCL11
3atopic dermatitis30.5IL4, CCL11, CCL22
4dermatitis30.4IL4, IFNG, CCL11, CCL22, CCR4, IGHE
5conjunctivitis30.4IGHE
6vernal keratoconjunctivitis30.4IGHE, CCL11, IL4, IL5, IL3
7allergic conjunctivitis30.2IGHE, CCL11, IL4, IL5
8corneal disease10.1
9cicatricial pemphigoid10.1
10stevens-johnson syndrome10.1
11alopecia10.1
12alopecia areata10.1
13herpes simplex10.1
14influenza10.1
15keratitis10.1
16keratoconus10.1
17ocular cicatricial pemphigoid10.1
18folliculitis10.1CCL11
19eosinophilic fasciitis10.1IL5
20eosinophilia-myalgia syndrome10.1IL5
21periapical granuloma10.1IL4
22malaria10.1IFNG
23aspergillosis10.1IFNG
24eczema herpeticum10.1IGHE
25allergic contact dermatitis10.1CCR4, IL5
26pleurisy10.1MUC16
27chronic eosinophilic pneumonia10.1CCL11, IL5
28giant papillary conjunctivitis10.1IL5, CCL11
29eosinophilic esophagitis10.1CCL11, IL5
30hypereosinophilic syndrome10.1IL3, IL5
31strongyloidiasis10.1IL5, IGHE
32leprosy10.1IL2
33dermatographia10.1IGHE, PRG2
34helminthiasis10.1IGHE, IL5
35pulmonary fibrosis10.1PRG2, CCR4, CCL22
36paragonimiasis10.1IGHE, IL5
37eye disease10.1MUC5AC, CCL11
38pneumonia10.1CCL22, CCL11, IL5
39filariasis10.1IGHE, IL5
40esophagitis10.1PRG2, CCL11, IL5
41mastocytosis10.1IGHE, IL5
42angioedema10.0IL5, IGHE
43immunodeficiency with hyper igm type 110.0IGHE, IL4
44cystadenocarcinoma10.0MUC5AC, MUC16
45visceral leishmaniasis10.0IFNG, IL4
46pulmonary disease, chronic obstructive10.0CCL11, CCR4, MUC5AC
47cervical adenocarcinoma10.0MUC5AC, MUC16
48kimura disease10.0IGHE, PRG2, IL5
49idiopathic pulmonary fibrosis10.0CCR4, CCL22, IFNG
50contact dermatitis10.0IGHE, CCR4, IL5

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

About this section

Drugs & Therapeutics for Atopic Keratoconjunctivitis

About this section
Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Atopic Keratoconjunctivitis

Drug clinical trials:

Search ClinicalTrials for Atopic Keratoconjunctivitis

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Search CenterWatch for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

About this section

Anatomical Context for Atopic Keratoconjunctivitis

About this section
Sources:
34MalaCards
See all sources

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

34
Eye, Bone marrow, Bone

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

About this section
Sources:
38MGI
See all sources

MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1IL3, IL5, IL2, IFNG
2MP:00053818.3MUC5AC, IFNG, IL4, IL2, IL5
3MP:00053887.5PRG2, CCR4, CCL11, IFNG, IL4, IL2
4MP:00053767.0IGHE, MUC5AC, IFNG, IL4, IL2, IL5
5MP:00053976.6IGHE, PRG2, CCR4, CCL11, IFNG, IL4
6MP:00053876.1IL3, IGHE, MUC5AC, PRG2, CCR4, CCL11

Publications for Atopic Keratoconjunctivitis

About this section
Sources:
53PubMed
See all sources

Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 73)
idTitleAuthorsYear
1
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
2
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
3
Atopic keratoconjunctivitis: A review. (24342754)
2013
4
Atopic keratoconjunctivitis. (23406935)
2013
5
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
6
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
7
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
8
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
9
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
10
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
11
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
12
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
13
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
14
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
15
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
16
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. (20482394)
2010
17
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
18
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
19
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
20
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
21
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
22
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
23
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
24
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
25
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. (16371796)
2006
26
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
27
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis. (15548799)
2004
28
A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. (15019322)
2004
29
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
30
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
31
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
32
Haemophilus influenzae corneal ulcer associated with atopic keratoconjunctivitis and herpes simplex keratitis. (11914228)
2002
33
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
34
Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)
1999
35
Analysis of tears in patients with atopic keratoconjunctivitis, using flow cytometry. (9483587)
1998
36
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
37
A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. (9754182)
1998
38
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry. (9441704)
1997
39
Atopic keratoconjunctivitis. (9269601)
1997
40
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
41
Penetrating keratoplasty in atopic keratoconjunctivitis. (8575184)
1995
42
Atopic keratoconjunctivitis. (22823113)
1994
43
Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with long-term topical cyclosporin A. (7842716)
1994
44
Atopic keratoconjunctivitis (AKC). (8344185)
1993
45
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
46
Atopic keratoconjunctivitis. (1976238)
1990
47
Plasmapheresis treatment in patients with severe atopic keratoconjunctivitis. (3174011)
1988
48
Atopic keratoconjunctivitis. (13411162)
1957
49
Atopic keratoconjunctivitis. (13065376)
1953
50
Atopic keratoconjunctivitis. (13102561)
1952

Variations for Atopic Keratoconjunctivitis

About this section

Expression for genes affiliated with Atopic Keratoconjunctivitis

About this section
Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

About this section
Sources:
51PathCards, 55R&D Systems, 5Cell Signaling Technology, 61Thomson Reuters, 39NCBI BioSystems Database, 13EMD Millipore, 31KEGG, 56Reactome, 54QIAGEN
See all sources

Pathways related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, IL4
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway61
9.7IFNG, IL4
39.7IFNG, IL2
49.7IFNG, IL2
5
Show member pathways
9.7IL2, IFNG
69.5IL5, IL4, CCL11
79.5IL4, IL5, IL3
8
Show member pathways
9.5IL3, IL5, IL2
9
Show member pathways
9.5CCR4, CCL22, CCL11
10
Show member pathways
9.5CCL11, CCL22, CCR4
119.4IL3, IL2, IL4
12
Show member pathways
Transcription NF kB signaling pathway61
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response61
9.4IL4, IFNG, CCL11
139.3IFNG, IL4, IL2
14
Show member pathways
Immune response IL 12 induced IFN gamma production61
9.3IL2, IL4, IFNG
15
Show member pathways
9.3IL2, IL4, IFNG
16
Show member pathways
9.1IFNG, IL2, IL5, IL3
17
Show member pathways
9.1IFNG, IL4, IL2, IL5
189.1IFNG, IL4, IL2, IL5
199.1IFNG, IL4, IL2, IL5
209.1IFNG, IL4, IL2, IL5
219.1IL5, IL2, IL4, IFNG
22
Show member pathways
BCR signaling pathway39
TCR Signaling Pathway39
9.1IFNG, IL4, IL2, IL5
23
Show member pathways
Immune response CD16 signaling in NK cells61
9.0IL3, IL2, IL4, IFNG
24
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
9.0IL4, CCL11, IGHE
25
Show member pathways
8.9PRG2, CCR4, CCL22, CCL11
268.7IFNG, IL4, IL2, IL5, IL3
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway39
8.7IFNG, IL4, IL2, IL5, IL3
28
Show member pathways
Type III interferon signaling39
8.7IL3, IL5, IL2, IL4, IFNG
298.7IGHE, CCL11, IL4, IL5
30
Show member pathways
Immune response BCR pathway61
Fc-epsilon receptor I signaling in mast cells39
8.7IGHE, IL4, IL5, IL3
31
Show member pathways
8.2CCL22, CCL11, IFNG, IL4, IL2, IL5
32
Show member pathways
8.1IL5, IL2, IL4, CCL11, CCL22, CCR4
33
Show member pathways
8.1CCR4, CCL22, CCL11, IL4, IL2, IL5
34
Show member pathways
7.9IL3, IL5, IL2, IL4, IFNG, CCL11
35
Show member pathways
7.7CCR4, CCL22, CCL11, IFNG, IL4, IL2
36
Show member pathways
7.6PRG2, CCR4, CCL22, CCL11, IL4, IL2

Compounds for genes affiliated with Atopic Keratoconjunctivitis

About this section
Sources:
46Novoseek, 52PharmGKB, 30IUPHAR, 12DrugBank, 62Tocris Bioscience, 25HMDB, 3BitterDB
See all sources

Compounds related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1salmeterol46 52 30 1212.6IL4, IL5, IL2, CCL11
2interferon gamma469.5IL4, IL2, IFNG
3glatiramer acetate46 1210.4IL4, IFNG, IL2, IL5
4il-12469.4IFNG, IL5, IL2, IL4
5con a469.4IL2, IL4, IFNG, IL5
6ltc4469.4CCL11, IL3, PRG2, IL5
7rolipram46 62 3011.4CCL11, IFNG, IL4, IL5
8polyinosinic-polycytidylic acid469.4IL5, IL4, IL2, IFNG
9unicap469.3IGHE, IL5, CCL11
10omalizumab46 1210.3IL4, IGHE, IL5
11methylcellulose469.3IFNG, IL4, IL5, IL3
12oxatomide469.3IGHE, IL5, IL3
13poly(i-c)469.2CCL11, IL4, IFNG, IL5, IL3
14gm-csf46 3010.2IL3, IL4, IL2, IL5, IFNG
15il 10469.1IL3, IL4, IFNG, IL2, IL5
16nedocromil sodium469.1IGHE, IL4, IL5, IL3
17ribavirin46 52 1211.1IL2, IL4, IFNG, IL3
18azelastine46 1210.1IL5, IGHE, IL4, IL3
19itraconazole46 1210.1IGHE, IL4, IL5, IL3
20montelukast46 52 30 1212.1IGHE, CCL11, IL4, IL5
21ccl346 3010.0IFNG, CCR4, CCL22, CCL11
22ovomucoid468.9IGHE, IL5, IL4
23melphalan46 52 1210.9IFNG, MUC16, IL4, IL3
24herbimycin a46 629.9IL4, IL3, IL5, IFNG, CCL11, IL2
25ionomycin468.8IFNG, CCL11, IL3, IL5, IL4, IL2
26pgd2468.8CCL11, PRG2, IGHE, IL5
27budesonide46 52 1210.7IL5, IL4, CCL11, IFNG, IGHE
28fluticasone propionate46 52 62 1211.7IL4, CCL11, IGHE, IFNG, IL5
29ivig468.7IGHE, IFNG, IL5, IL3, IL4
30tacrolimus46 52 1210.6IL4, IL3, IL2, CCL22, IL5, IFNG
31sb 20358046 629.6MUC5AC, CCL11, IL5, IL4, IFNG, CCL22
32thymidine46 259.6IL5, IL2, CCL11, IFNG, IL4, IL3
33genistein46 30 62 3 25 1213.6PRG2, IL3, CCL11, IFNG, IL2, IL5
34methacholine46 52 1210.4IL5, IL4, CCL11, CCL22, PRG2, IGHE
35cyclophosphamide46 52 1210.4IL4, IL2, MUC16, IL3, IGHE
36hydrocortisone46 3 62 1211.3IGHE, IFNG, IL4, IL5, IL3, IL2
37pge2468.3IL4, IL5, IL2, MUC5AC, CCL22, CCL11
38allergens468.2IFNG, PRG2, IL5, IL4, IGHE, CCL11
39rantes468.2IL5, IL2, CCL22, IFNG, CCL11, CCR4
40tarc468.0CCL22, IFNG, IL5, IL4, CCL11, CCR4
41indomethacin46 30 62 1210.8IFNG, IL4, IGHE, PRG2, CCL11, IL2
42actinomycin d467.8IFNG, IL4, IL3, IL2, CCL11, PRG2
43cyclosporin a46 30 629.8IFNG, IL2, IL5, IL3, CCL22, IGHE
44prednisolone46 30 129.7IFNG, CCR4, IL2, IL5, CCL11, IGHE
45vegf467.7CCL11, IL5, IL4, IFNG, MUC16, IL2
46cycloheximide467.6IL3, IL2, IL4, IFNG, IGHE, IL5
47retinoic acid46 258.1CCL11, CCR4, PRG2, IL3, MUC5AC, IGHE
48tyrosine467.1CCR4, MUC16, IL5, IL2, IL4, CCL11
49histamine46 30 258.7CCL22, CCL11, IL3, IL5, IL2, IGHE
50dexamethasone46 52 30 129.7IL5, IL4, IFNG, MUC5AC, CCL11, CCL22

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

About this section
Sources:
17Gene Ontology
See all sources

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL4, IFNG, CCR4
2extracellular spaceGO:0056157.6IL3, MUC16, CCL22, CCL11, IFNG, IL4
3extracellular regionGO:0055766.9IGHE, PRG2, CCL22, CCL11, IFNG, IL2

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:05102410.0IL5, IL2
2positive regulation of MHC class II biosynthetic processGO:0453489.9IL4, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.9IFNG, IL4
4defense response to protozoanGO:0428329.8IFNG, IL4
5positive regulation of activated T cell proliferationGO:0421049.8IL2, IL4
6positive regulation of B cell proliferationGO:0308909.7IL4, IL2, IL5
7positive regulation of T cell proliferationGO:0421029.7IL4, IFNG
8response to radiationGO:0093149.7CCL11, CCR4
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL4, IL2, IL3
10response to virusGO:0096159.6IFNG, CCL11, CCL22
11positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IL4, IFNG
12extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5IL2, IL4
13cell-cell signalingGO:0072679.4CCL22, IL2, IL3
14inflammatory responseGO:0069549.4CCR4, CCL22, CCL11, IL5
15chemotaxisGO:0069359.4IL4, CCL11, CCL22, CCR4
16immune responseGO:0069557.1IL3, IGHE, PRG2, CCR4, CCL22, CCL11

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.9CCL11, CCL22
2growth factor activityGO:0080838.9IL4, IL2, IL5, IL3
3cytokine activityGO:0051258.6IL3, IL5, IL2, IL4, IFNG

Products for genes affiliated with Atopic Keratoconjunctivitis

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopic Keratoconjunctivitis

About this section
4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet