MCID: ATP013
MIFTS: 35

Atopic Keratoconjunctivitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
51Orphanet, 65UMLS, 28ICD10 via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 51 65

Characteristics:

Orphanet epidemiological data:

51
atopic keratoconjunctivitis:
Prevalence: 1-5/10000 (Europe)

Classifications:

Orphanet: 51 
Rare eye diseases


External Ids:

Orphanet51 163934
ICD10 via Orphanet28 H16.2
UMLS via Orphanet66 C1274788
UMLS65 C1274788

Summaries for Atopic Keratoconjunctivitis

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MalaCards based summary: Atopic Keratoconjunctivitis is related to malaria and lattice corneal dystrophy. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (C-C Motif Chemokine Ligand 22), and among its related pathways are IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types and Immune response_MIF-mediated glucocorticoid regulation. Affiliated tissues include eye, breast and bone, and related mouse phenotypes are digestive/alimentary and respiratory system.

Related Diseases for Atopic Keratoconjunctivitis

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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 193)
idRelated DiseaseScoreTop Affiliating Genes
1malaria29.5IFNG, IL2, IL4, IL5
2lattice corneal dystrophy10.4IL3, IL5
3loeffler syndrome10.4IL3, IL5
4kyphoscoliotic heart disease10.4IL4, IL5
5status asthmaticus10.4IL4, IL5
6benign paroxysmal positional nystagmus10.3IL4, IL5
7superficial urinary bladder cancer10.3IL4, IL5
8eosinophilic gastroenteritis10.3IL4, IL5
9mobitz type ii atrioventricular block10.3IL4, IL5
10granulomatous amebic encephalitis10.3IL4, IL5
11motor peripheral neuropathy10.3IL4, IL5
12acantholytic variant squamous cell breast carcinoma10.3IL4, IL5
13eosinophilic granulomatosis with polyangiitis10.3IFNG, IL5
14western equine encephalitis10.3IL2, IL3
15prepuce cancer10.3IL4, IL5
16cholesteatoma of attic10.3IFNG, IL5
17melorheostosis10.3IL4, IL5
18orbit lymphoma10.3IFNG, IL5
19familial hyperlipidemia10.3IL4, IL5
20cd45 deficiency10.3IL2, IL4
21maxillary neoplasm10.3IL2, IL4
22cycloplegia10.3IFNG, IL4
23female breast central part cancer10.3IL2, IL5
24disseminated eosinophilic collagen disease10.3IL4, IL5
25enamel caries10.3IL4, IL5
26dioctophymiasis10.3IFNG, IL4
27neonatal infective mastitis10.2IFNG, IL5
28soft tissue sarcoma childhood10.2IFNG, IL3
29acalculous cholecystitis10.2IL4, IL5
30spinal polio10.2IFNG, IL2
31buruli ulcer10.2IFNG, IL4
32chronic conjunctivitis10.2IL2, IL4
33graft-versus-host disease, protection against10.2IFNG, IL2
34early-onset, autosomal dominant alzheimer disease10.2IFNG, IL4
35retroperitoneal germ cell neoplasm10.2CCL22, IL3, IL5
36chronic demyelinizing neuropathy with igm monoclonal10.2IFNG, IL2
37louping ill10.2IFNG, IL2
38central nervous system melanocytic neoplasm10.2IFNG, IL4
39idiopathic interstitial pneumonia10.2CCL22, IL4, IL5
40kohler's disease10.2IL4, IL5, MUC5AC
41soft palate cancer10.2IFNG, IL4
42peanut allergy10.2IGHE, IL4
43hyper-reninism10.2IGHE, IL4
44argentine hemorrhagic fever10.2IFNG, IL2
45craniofacioskeletal syndrome10.2IGHE, IL4
46sarcoid meningitis10.2IFNG, IL4
47opioid abuse10.2IL4, IL5
48diffuse cutaneous mastocytosis10.2IL2, IL3
49meige syndrome10.2IFNG, IL4
50polycystic kidney disease10.2IL2, IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
Miconazoleapproved, investigationalPhase 3302622916-47-84189
Synonyms:
(+-)-1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole
1-(2,4-dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl) imidazole
1-[2,4-Dichloro- beta-([2,4-dichloro- benzyl]oxy)phenethyl]imidazole
1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole
1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole
1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole
1-[2-(2,4-dichlorophenyl)-2-{[(2,4-dichlorophenyl)methyl]oxy}ethyl]-1H-imidazole
1-{2-[(2,4-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
22832-87-7 (NITRATE)
22916-47-8
75319-47-0
AB00053500
AC1L1HM1
AKOS001574474
Aflorix(nitrate)
Albistat(nitrate)
Andergin(nitrate)
BPBio1_000279
BRD-A82396632-001-03-0
BRD-A82396632-008-02-7
BRN 0965511
BSPBio_000253
BSPBio_002033
CCRIS 7924
CHEBI:6923
CHEMBL91
CID4189
CPD-4501
Conofite(nitrate)
D00416
DB01110
Dactarin
Daktarin IV
Daktarin iv
Desenex
DivK1c_000156
EINECS 245-324-5
Epi-Monistat(nitrate)
Femizol-M
Florid(nitrate)
Gyno-Daktar(nitrate)
HMS1568M15
HMS2090B21
I14-14342
IDI1_000156
Imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl)methoxy)ethyl)- (9CI)
KBio1_000156
KBio2_001445
KBio2_004013
KBio2_006581
KBio3_001533
KBioGR_000581
KBioSS_001445
LS-78378
Lotrimin AF(nitrate)
MCZ
MJR 1762
MLS002222203
Makesense
Micantin (nitrate)
Micatin
 
Miconasil Nitrate
Miconazol
Miconazol [INN-Spanish]
Miconazole
Miconazole (JP15/USP/INN)
Miconazole 3
Miconazole 3 Combination Pack
Miconazole 7 Combination Pack
Miconazole [USAN:BAN:INN:JAN]
Miconazole nitrate salt
Miconazole-7
Miconazolo
Miconazolo [DCIT]
Miconazolum
Miconazolum [INN-Latin]
Micozole
Minostate
MolPort-002-557-553
Monazole 7
Monista (nitrate)
Monistat
Monistat (TN)
Monistat 1 Combination Pack
Monistat 3 Dual-Pak
Monistat 3 Vaginal Ovules
Monistat 5 Tampon
Monistat 7 Dual-Pak
Monistat 7 Vaginal Suppositories
Monistat Dual- PAK
Monistat IV
Monistat iv (TN)
Monistat iv (tn)
Monistat-Derm
NCI60_001353
NCI60_001380
NINDS_000156
NSC 170986
NSC169434
NSC170986
Novo-Miconazole Vaginal Ovules
Oprea1_091955
Oravig
Prestwick0_000067
Prestwick1_000067
Prestwick2_000067
Prestwick3_000067
Prestwick_335
R 18134
R-14,889
Rash Relief Antifungal
SMR001307249
SPBio_000976
SPBio_002174
STK834405
STOCK1S-93556
Spectrum2_001048
Spectrum3_000507
Spectrum4_000061
Spectrum5_001297
Spectrum_000965
UNII-7NNO0D7S5M
Vusion
Zimycan
imidazole, 1-(2-(2,4-dichlorophenyl)-2-((2,4-dichlorophenyl) methoxy)ethyl)- (9CI)
miconazole
2Immunosuppressive AgentsPhase 310422
3Ophthalmic SolutionsPhase 31006
4Pharmaceutical SolutionsPhase 37004
5Immunologic FactorsPhase 318483
6Dermatologic AgentsPhase 34555
7Anti-Infective AgentsPhase 317220
8Antirheumatic AgentsPhase 38496
9Calcineurin InhibitorsPhase 31223
10Antifungal AgentsPhase 33015
11CyclosporinsPhase 3873
12Tetrahydrozoline542

Interventional clinical trials:

idNameStatusNCT IDPhase
1Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic KeratoconjunctivitisCompletedNCT00884585Phase 3
2Long-term Topical Cyclosporine for Atopic KeratoconjunctivitisCompletedNCT00987467

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

33
Eye, Breast, Bone, Liver, Kidney, Testes, Lung

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053818.4IFNG, IL2, IL4, IL5, MUC5AC
2MP:00053888.1IFNG, IL2, IL4, IL5, PRG2

Publications for Atopic Keratoconjunctivitis

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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 82)
idTitleAuthorsYear
1
Wernicke's encephalopathy as a complication of gastroparesis after emergency partial antrectomy. (26242512)
2015
2
B7-H3 expression in children with asthma exacerbation. (26108069)
2015
3
In vitro and in vivo broad antiviral activity of peptides homologous to fusion glycoproteins of Newcastle disease virus and Marek's disease virus. (24412629)
2014
4
Long-term outcomes of endoscopic maxillary mega-antrostomy for refractory chronic maxillary sinusitis. (25312656)
2014
5
Molecular genetics of achromatopsia in Newfoundland reveal genetic heterogeneity, founder effects and the first cases of Jalili syndrome in North America. (23362848)
2013
6
A prolyl-isomerase mediates dopamine-dependent plasticity and cocaine motor sensitization. (23911326)
2013
7
Effectiveness of repeat glycerol rhizotomy in treating recurrent trigeminal neuralgia. (22067421)
2012
8
Chinese patent medicine liu wei di huang wan combined with antihypertensive drugs, a new integrative medicine therapy, for the treatment of essential hypertension: a systematic review of randomized controlled trials. (23258998)
2012
9
A canine autosomal recessive model of collagen type III glomerulopathy. (22890554)
2012
10
Current treatment status in patients with severe aortic valve stenosis and outcome of long term follow-up at advanced age: a Chinese single center study. (22040496)
2011
11
Imprinting in the schizophrenia candidate gene GABRB2 encoding GABA(A) receptor I^(2) subunit. (20404824)
2011
12
Scoping a perforated bleeding peptic ulcer: learning points. (22699475)
2011
13
Intermediate volume on computed tomography imaging defines a fibrotic compartment that predicts glomerular filtration rate decline in autosomal dominant polycystic kidney disease patients. (21683674)
2011
14
Recovery of awareness after hyperacute hepatic encephalopathy with "flat" EEG, severe brain edema and deep coma. (20568022)
2010
15
Identification of relaxin-responsive cells in the human choriodecidua at term. (19416174)
2009
16
Superficial mucoceles in chronic graft-versus-host disease: a case report and review of the literature. (19146147)
2009
17
Lipid profiles of canine invasive transitional cell carcinoma of the urinary bladder and adjacent normal tissue by desorption electrospray ionization imaging mass spectrometry. (19810710)
2009
18
Inhibition of human parainfluenza virus type 3 infection by novel small molecules. (17964670)
2008
19
Metabolic syndrome pathophysiology: the role of adipose tissue. (17270403)
2007
20
Electroencephalographic and imaging profile in a subacute sclerosing panencephalitis (SSPE) cohort: a correlative study. (17652019)
2007
21
Effects of cyclosporine on transplant tolerance: the role of IL-2. (17617853)
2007
22
Studies of the SIM1 gene in relation to human obesity and obesity-related traits. (16924270)
2007
23
Parent report of stereotyped behaviors, social interaction, and developmental disturbances in individuals with Angelman syndrome. (17019625)
2007
24
A novel multi-array immunoassay device for tumor markers based on insert-plug model of piezoelectric immunosensor. (17442563)
2007
25
Peroxisome proliferator-activated receptor (PPAR)gamma is expressed by human spermatozoa: its potential role on the sperm physiology. (16972250)
2006
26
Expression of Haemophilus ducreyi collagen binding outer membrane protein NcaA is required for virulence in swine and human challenge models of chancroid. (16622201)
2006
27
Linkage between A(TA)7TAA and -3279T>G mutations in UGT1A1 is not essential for pathogenesis of Gilbert syndrome. (17105600)
2006
28
Inhibitory control of TGF-beta1 on the activation of Rap1, CD11b, and transendothelial migration of leukocytes. (15746186)
2005
29
Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation. (16185715)
2005
30
No relationship of -627 interleukin-10 promoter polymorphism in Chinese patients with rheumatoid arthritis. (15221281)
2005
31
Antioxidants modulate thyroid hormone- and noradrenaline-induced DNA damage in human sperm. (15215333)
2004
32
cDNA cloning of a defender against apoptotic cell death 1 (DAD1) homologue, responsive to external temperature stimulus from the spider, Araneus ventricosus. (12781979)
2003
33
Rosiglitazone improves glucose metabolism in nondiabetic uremic patients on CAPD. (14520628)
2003
34
Immunological reactions in liver graft perireperfusion in living donor liver transplantation--change of expression of adhesion molecules, deposition of immunoglobulins and cytokine level. (12845988)
2003
35
Two novel phosphorylation sites on FKHR that are critical for its nuclear exclusion. (11980723)
2002
36
Water transport in the kidney and nephrogenic diabetes insipidus. (12322698)
2002
37
Two cases of large solitary fibrous tumors of the pleura associated with fasting hypoglycemia. (11372615)
2001
38
Immunodetectable cyclin D(1)is associated with oestrogen receptor but not Ki67 in normal, cancerous and precancerous breast lesions. (11308255)
2001
39
Mechanisms of NF-kappaB activation by the HTLV type 1 tax protein. (11080795)
2000
40
Functional characterization of DNase X, a novel endonuclease expressed in muscle cells. (10858283)
2000
41
In situ RT-PCR allows the detection of ornithine decarboxylase mRNA in paraffin embedded archival human hyperplastic breast tissues. (10563250)
1999
42
HLA-DMA and HLA-DMB alleles in German patients with type 1 diabetes mellitus. (10519369)
1999
43
Enhanced apoptosis predicts shortened survival in non-small cell lung carcinoma. (7585640)
1995
44
Pulmonary alveolar proteinosis in rats after administration of quartz: its possible role in morphogenesis of lung cancer. (8138559)
1994
45
Association of breast cancer and meningioma. Report of 12 new cases and review of the literature. (8351240)
1993
46
Interactions of C1(-)-inhibitors from normal persons and patients with type II hereditary angioneurotic edema with purified activated Hageman factor (factor XIIa). (2302459)
1990
47
A case of nemaline myopathy with ophthalmoplegia and mitochondrial abnormalities. (6247453)
1980
48
Erythema infectiosum: an outbreak of "slapped cheek" disease in north Devon. (1260394)
1976
49
Early lesion of Pelizaeus-Merzbacher disease: electron microscopic and biochemical study. (4123133)
1973
50
NECROBIOSIS LIPOIDICA: A HISTOPATHOLOGICAL AND HISTOCHEMICAL STUDY. (14319916)
1965

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 27)
idSuper pathwaysScoreTop Affiliating Genes
19.8IL4, IL5
29.6IFNG, IL2
39.6IFNG, IL2
4
Show member pathways
9.6IFNG, IL2
59.4IL3, IL4, IL5
6
Show member pathways
9.4IL2, IL3, IL5
79.3IFNG, IL2, IL3
8
Show member pathways
9.2IFNG, IL2, IL4
99.2IGHE, IL4, IL5
108.9IFNG, IL2, IL4, IL5
118.9IFNG, IL2, IL4, IL5
128.9IFNG, IL2, IL4, IL5
138.9IFNG, IL2, IL4, IL5
14
Show member pathways
8.9IFNG, IL2, IL4, IL5
158.9IFNG, IL2, IL4, IL5
16
Show member pathways
8.9IFNG, IL2, IL3, IL4
17
Show member pathways
8.8IGHE, IL3, IL4, IL5
18
Show member pathways
8.7CCL22, IL2, IL3, IL4, IL5
198.7IFNG, IL2, IL4, PRG2
208.6CCL22, IFNG, IL2, IL4, IL5
21
Show member pathways
8.6IFNG, IL2, IL3, IL4, IL5
22
Show member pathways
8.6IFNG, IL2, IL3, IL4, IL5
23
Show member pathways
8.6IFNG, IL2, IL3, IL4, IL5
248.6IFNG, IL2, IL3, IL4, IL5
25
Show member pathways
8.3CCL22, IFNG, IL2, IL3, IL4, IL5
26
Show member pathways
8.3CCL22, IFNG, IL2, IL3, IL4, IL5
27
Show member pathways
8.0IFNG, IL2, IL3, IL4, IL5, PRG2

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 20)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of T cell differentiationGO:004558210.4IL2, IL4
2extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.3IL2, IL4
3positive regulation of chemokine biosynthetic processGO:004508010.3IFNG, IL4
4defense response to protozoanGO:004283210.3IFNG, IL4
5positive regulation of B cell activationGO:005087110.2IGHE, IL4
6positive regulation of MHC class II biosynthetic processGO:004534810.1IFNG, IL4
7positive regulation of B cell proliferationGO:003089010.0IL2, IL4, IL5
8positive regulation of tyrosine phosphorylation of Stat5 proteinGO:004252310.0IL2, IL3, IL4
9positive regulation of peptidyl-tyrosine phosphorylationGO:00507319.9IL3, IL4, IL5
10epidermal growth factor receptor signaling pathwayGO:00071739.9IL2, IL3, IL5
11cytokine-mediated signaling pathwayGO:00192219.9IFNG, IL3, IL5
12positive regulation of T cell proliferationGO:00421029.8IFNG, IL2, IL4
13positive regulation of GTPase activityGO:00435479.8CCL22, IL3, IL5
14positive regulation of isotype switching to IgG isotypesGO:00483049.7IFNG, IL2, IL4
15vascular endothelial growth factor receptor signaling pathwayGO:00480109.7IL2, IL3, IL5
16insulin receptor signaling pathwayGO:00082869.7IL2, IL3, IL5
17innate immune responseGO:00450878.8IGHE, IL2, IL3, IL5
18defense response to bacteriumGO:00427428.6IFNG, IGHE, PRG2
19positive regulation of cell proliferationGO:00082848.5IFNG, IL2, IL3, IL4, IL5
20immune responseGO:00069558.3CCL22, IFNG, IL2, IL3, IL4, IL5

Sources for Atopic Keratoconjunctivitis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet