MCID: ATP013
MIFTS: 40

Atopic Keratoconjunctivitis malady

Eye diseases, Rare diseases categories

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
47Orphanet, 60UMLS, 26ICD10 via Orphanet, 61UMLS via Orphanet
See all sources

Atopic Keratoconjunctivitis, Aliases & Descriptions:

Name: Atopic Keratoconjunctivitis 47 60


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 47 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

47
atopic keratoconjunctivitis:
Prevalence: 1-5/10000 (Europe)


External Ids:

Orphanet47 163934
ICD10 via Orphanet26 H16.2
UMLS via Orphanet61 C1274788

Summaries for Atopic Keratoconjunctivitis

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MalaCards based summary: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and corneal ulcer. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (chemokine (C-C motif) ligand 22), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Jak/Stat Pathway. The compounds salmeterol and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Related Diseases for Atopic Keratoconjunctivitis

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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis32.2IL5, CCL11
2corneal ulcer31.0MUC5AC, CCL11, PRG2
3conjunctivitis30.9IGHE
4dermatitis30.9IGHE, IL4
5atopic dermatitis30.8CCL11, IL4, CCL22
6allergic conjunctivitis30.2CCL11, IGHE, IL4, IL5
7vernal keratoconjunctivitis30.1IL5, IL4, IGHE, CCL11, IL3
8folliculitis10.5CCL11
9eosinophilic fasciitis10.5IL5
10eosinophilia-myalgia syndrome10.5IL5
11periapical granuloma10.5IL4
12malaria10.4IFNG
13aspergillosis10.4IFNG
14eczema herpeticum10.4IGHE
15allergic contact dermatitis10.3IL5, CCR4
16chronic eosinophilic pneumonia10.3CCL11, IL5
17pleurisy10.3MUC16
18giant papillary conjunctivitis10.3CCL11, IL5
19esophagitis, eosinophilic, 110.3CCL11, IL5
20hypereosinophilic syndrome, idiopathic, resistant to imatinib10.3IL5, IL3
21strongyloidiasis10.3IGHE, IL5
22leprosy10.3IL2
23dermatographia10.3IGHE, PRG2
24pulmonary fibrosis10.3CCL22, CCR4, PRG2
25parasitic helminthiasis infectious disease10.3IL5, IGHE
26paragonimiasis10.3IL5, IGHE
27spiradenoma10.3CCL11, MUC5AC
28pneumonia10.2CCL11, CCL22, IL5
29filariasis10.2IGHE, IL5
30esophagitis10.2PRG2, CCL11, IL5
31mastocytosis10.2IGHE, IL5
32angioedema10.2IGHE, IL5
33immunodeficiency, x-linked, with hyper-igm10.2IL4, IGHE
34cystadenocarcinoma10.2MUC16, MUC5AC
35visceral leishmaniasis10.2IFNG, IL4
36pulmonary disease, chronic obstructive10.2MUC5AC, CCL11, CCR4
37cervical adenocarcinoma10.2MUC5AC, MUC16
38kimura disease10.2IGHE, PRG2, IL5
39pulmonary fibrosis, idiopathic10.2CCL22, CCR4, IFNG
40contact dermatitis10.2IGHE, CCR4, IL5
41urticaria10.2PRG2, IGHE
42keratitis10.2
43alopecia10.2
44keratoconus10.2
45cicatricial pemphigoid10.2
46alopecia areata10.2
47corneal disease10.2
48herpes simplex10.2
49influenza10.2
50haemophilus influenzae10.2

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Drug clinical trials:

Search ClinicalTrials for Atopic Keratoconjunctivitis

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

31
Eye, Bone marrow, Bone

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1IL3, IL5, IL2, IFNG
2MP:00053818.3MUC5AC, IFNG, IL4, IL2, IL5
3MP:00053887.5PRG2, CCR4, CCL11, IFNG, IL4, IL2
4MP:00053767.0IGHE, MUC5AC, IFNG, IL4, IL2, IL5
5MP:00053976.6IGHE, PRG2, CCR4, CCL11, IFNG, IL4
6MP:00053876.1IL3, IGHE, MUC5AC, PRG2, CCR4, CCL11

Publications for Atopic Keratoconjunctivitis

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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 78)
idTitleAuthorsYear
1
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. (25682856)
2015
2
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. (25705372)
2014
3
Central corneal thickness in patients with atopic keratoconjunctivitis. (25240805)
2014
4
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
5
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
6
Atopic keratoconjunctivitis: A review. (24342754)
2013
7
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
8
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
9
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. (22092652)
2012
10
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
11
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
12
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
13
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
14
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
15
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
16
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
17
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
18
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. (20482394)
2010
19
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. (18721214)
2009
20
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
21
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
22
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
23
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
24
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
25
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
26
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
27
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
28
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. (16371796)
2006
29
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
30
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis. (15548799)
2004
31
A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. (15019322)
2004
32
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
33
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
34
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
35
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
36
Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)
1999
37
Analysis of tears in patients with atopic keratoconjunctivitis, using flow cytometry. (9483587)
1998
38
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
39
A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. (9754182)
1998
40
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry. (9441704)
1997
41
Atopic keratoconjunctivitis. (9269601)
1997
42
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
43
Atopic keratoconjunctivitis. (22823113)
1994
44
Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with long-term topical cyclosporin A. (7842716)
1994
45
Atopic keratoconjunctivitis (AKC). (8344185)
1993
46
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
47
Atopic keratoconjunctivitis. (1976238)
1990
48
Atopic keratoconjunctivitis. (13411162)
1957
49
Atopic keratoconjunctivitis. (13065376)
1953
50
Atopic keratoconjunctivitis. (13102561)
1952

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL4, IL5
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway58
9.7IFNG, IL4
3
Show member pathways
9.7IFNG, IL2
49.7IL2, IFNG
59.7IL2, IFNG
69.5IL4, IL5, IL3
7
Show member pathways
9.5IL2, IL5, IL3
8
Show member pathways
9.5CCR4, CCL22, CCL11
9
Show member pathways
9.5CCR4, CCL22, CCL11
109.4IL2, IL3, IL4
11
Show member pathways
Transcription NF kB signaling pathway58
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response58
9.4IL4, CCL11, IFNG
12
Show member pathways
Immune response IL 12 induced IFN gamma production58
9.3IFNG, IL4, IL2
139.3IFNG, IL4, IL2
14
Show member pathways
9.3IL4, IFNG, IL2
15
Show member pathways
9.1IFNG, IL2, IL5, IL3
16
Show member pathways
9.1IFNG, IL5, IL2, IL4
179.1IL5, IL2, IL4, IFNG
189.1IFNG, IL4, IL2, IL5
199.1IFNG, IL4, IL2, IL5
20
Show member pathways
BCR signaling pathway36
TCR Signaling Pathway36
9.1IL4, IL5, IL2, IFNG
219.1IL2, IL4, IFNG, IL5
22
Show member pathways
Immune response CD16 signaling in NK cells58
9.0IL2, IL3, IL4, IFNG
23
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
9.0IL4, CCL11, IGHE
24
Show member pathways
8.9CCR4, PRG2, CCL11, CCL22
25
Show member pathways
Calcium signaling in the CD4+ TCR pathway36
8.7IL4, IL2, IFNG, IL3, IL5
26
Show member pathways
Type III interferon signaling36
8.7IL3, IFNG, IL4, IL2, IL5
278.7IL3, IL5, IL4, IFNG, IL2
288.7CCL11, IL5, IL4, IGHE
29
Show member pathways
Immune response BCR pathway58
Fc-epsilon receptor I signaling in mast cells36
8.7IGHE, IL4, IL5, IL3
30
Show member pathways
8.2CCL11, IFNG, IL4, IL2, CCL22, IL5
31
Show member pathways
8.1IL5, IL3, IL4, CCL11, CCL22, CCR4
32
Show member pathways
8.1CCR4, CCL11, CCL22, IL4, IL2, IL5
33
Show member pathways
7.9IL2, PRG2, CCL11, IFNG, IL4, IL3
34
Show member pathways
7.7CCL22, CCR4, CCL11, IL5, IFNG, IL4
35
Show member pathways
7.6IL5, IL3, PRG2, CCR4, CCL22, CCL11

Compounds for genes affiliated with Atopic Keratoconjunctivitis

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Compounds related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1salmeterol43 49 28 1212.6IL4, IL5, IL2, CCL11
2interferon gamma439.5IL4, IL2, IFNG
3glatiramer acetate43 1210.4IL4, IFNG, IL2, IL5
4il-12439.4IFNG, IL5, IL2, IL4
5con a439.4IL2, IL4, IFNG, IL5
6ltc4439.4CCL11, IL3, PRG2, IL5
7rolipram43 59 2811.4CCL11, IFNG, IL4, IL5
8polyinosinic-polycytidylic acid439.4IL5, IL4, IL2, IFNG
9unicap439.3IGHE, IL5, CCL11
10omalizumab43 1210.3IL4, IGHE, IL5
11methylcellulose439.3IFNG, IL4, IL5, IL3
12oxatomide439.3IGHE, IL5, IL3
13poly(i-c)439.2CCL11, IL4, IFNG, IL5, IL3
14gm-csf43 2810.2IL3, IL4, IL2, IL5, IFNG
15il 10439.1IL3, IL4, IFNG, IL2, IL5
16nedocromil sodium439.1IGHE, IL4, IL5, IL3
17ribavirin43 49 1211.1IL2, IL4, IFNG, IL3
18azelastine43 1210.1IL5, IGHE, IL4, IL3
19itraconazole43 1210.1IGHE, IL4, IL5, IL3
20montelukast43 49 28 1212.1IGHE, CCL11, IL4, IL5
21ccl343 2810.0IFNG, CCR4, CCL22, CCL11
22ovomucoid438.9IGHE, IL5, IL4
23melphalan43 49 1210.9IFNG, MUC16, IL4, IL3
24herbimycin a43 599.9IL4, IL3, IL5, IFNG, CCL11, IL2
25ionomycin438.8IFNG, CCL11, IL3, IL5, IL4, IL2
26pgd2438.8CCL11, PRG2, IGHE, IL5
27budesonide43 49 1210.7IL5, IL4, CCL11, IFNG, IGHE
28fluticasone propionate43 49 59 1211.7IL4, CCL11, IGHE, IFNG, IL5
29ivig438.7IGHE, IFNG, IL5, IL3, IL4
30tacrolimus43 49 1210.6IL4, IL3, IL2, CCL22, IL5, IFNG
31sb 20358043 599.6MUC5AC, CCL11, IL5, IL4, IFNG, CCL22
32thymidine43 249.6IL5, IL2, CCL11, IFNG, IL4, IL3
33genistein43 28 59 2 24 1213.6PRG2, IL3, CCL11, IFNG, IL2, IL5
34methacholine43 49 1210.4IL5, IL4, CCL11, CCL22, PRG2, IGHE
35cyclophosphamide43 49 1210.4IL4, IL2, MUC16, IL3, IGHE
36hydrocortisone43 2 59 1211.3IGHE, IFNG, IL4, IL5, IL3, IL2
37pge2438.3IL4, IL5, IL2, MUC5AC, CCL22, CCL11
38allergens438.2IFNG, PRG2, IL5, IL4, IGHE, CCL11
39rantes438.2IL5, IL2, CCL22, IFNG, CCL11, CCR4
40tarc438.0CCL22, IFNG, IL5, IL4, CCL11, CCR4
41indomethacin43 28 59 1210.8IFNG, IL4, IGHE, PRG2, CCL11, IL2
42actinomycin d437.8IFNG, IL4, IL3, IL2, CCL11, PRG2
43cyclosporin a43 28 599.8IFNG, IL2, IL5, IL3, CCL22, IGHE
44prednisolone43 28 129.7IFNG, CCR4, IL2, IL5, CCL11, IGHE
45vegf437.7CCL11, IL5, IL4, IFNG, MUC16, IL2
46cycloheximide437.6IL3, IL2, IL4, IFNG, IGHE, IL5
47retinoic acid43 248.1CCL11, CCR4, PRG2, IL3, MUC5AC, IGHE
48tyrosine437.1CCR4, MUC16, IL5, IL2, IL4, CCL11
49histamine43 28 248.7CCL22, CCL11, IL3, IL5, IL2, IGHE
50dexamethasone43 49 28 129.7IL5, IL4, IFNG, MUC5AC, CCL11, CCL22

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.3IL4, IFNG, CCR4
2extracellular spaceGO:00056157.6IL3, MUC16, CCL22, CCL11, IFNG, IL4
3extracellular regionGO:00055766.9IGHE, PRG2, CCL22, CCL11, IFNG, IL2

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:005102410.0IL5, IL2
2positive regulation of MHC class II biosynthetic processGO:00453489.9IL4, IFNG
3positive regulation of chemokine biosynthetic processGO:00450809.9IFNG, IL4
4defense response to protozoanGO:00428329.8IFNG, IL4
5positive regulation of activated T cell proliferationGO:00421049.8IL2, IL4
6positive regulation of B cell proliferationGO:00308909.7IL4, IL2, IL5
7positive regulation of T cell proliferationGO:00421029.7IL4, IFNG
8response to radiationGO:00093149.7CCL11, CCR4
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:00425239.7IL4, IL2, IL3
10response to virusGO:00096159.6IFNG, CCL11, CCL22
11positive regulation of isotype switching to IgG isotypesGO:00483049.6IL2, IL4, IFNG
12extrinsic apoptotic signaling pathway in absence of ligandGO:00971929.5IL2, IL4
13cell-cell signalingGO:00072679.4CCL22, IL2, IL3
14inflammatory responseGO:00069549.4CCR4, CCL22, CCL11, IL5
15chemotaxisGO:00069359.4IL4, CCL11, CCL22, CCR4
16immune responseGO:00069557.1IL3, IGHE, PRG2, CCR4, CCL22, CCL11

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00080099.9CCL11, CCL22
2growth factor activityGO:00080838.9IL4, IL2, IL5, IL3
3cytokine activityGO:00051258.6IL3, IL5, IL2, IL4, IFNG

Products for genes affiliated with Atopic Keratoconjunctivitis

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Sources for Atopic Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet