MCID: ATP013
MIFTS: 46

Atopic Keratoconjunctivitis malady

Eye diseases, Rare diseases categories
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Summaries for Atopic Keratoconjunctivitis

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MalaCards based summary: Atopic Keratoconjunctivitis is related to keratoconjunctivitis and corneal ulcer. An important gene associated with Atopic Keratoconjunctivitis is CCL22 (chemokine (C-C motif) ligand 22), and among its related pathways are IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types and Jak/Stat Pathway. The compounds salmeterol and interferon gamma have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and bone, and related mouse phenotypes are tumorigenesis and digestive/alimentary.

Aliases & Classifications for Atopic Keratoconjunctivitis

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Sources:
48Orphanet, 62UMLS, 26ICD10 via Orphanet, 63UMLS via Orphanet
See all sources

Atopic Keratoconjunctivitis, Aliases & Descriptions:

Name: Atopic Keratoconjunctivitis 48 62


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 48 
Rare eye diseases


Characteristics (Orphanet epidemiological data):

48
atopic keratoconjunctivitis:
Prevalence: 1-5/10000


External Ids:

ICD10 via Orphanet26 H16.2
UMLS via Orphanet63 C1274788

Related Diseases for Atopic Keratoconjunctivitis

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Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 126)
idRelated DiseaseScoreTop Affiliating Genes
1keratoconjunctivitis32.2CCL11, IL5
2corneal ulcer31.1MUC5AC, PRG2, CCL11
3conjunctivitis30.9IGHE
4atopic dermatitis30.8IL4, CCL11, CCL22
5allergic conjunctivitis30.2IGHE, CCL11, IL4, IL5
6vernal keratoconjunctivitis30.1IGHE, CCL11, IL4, IL5, IL3
7dermatitis29.8IL4, IFNG, CCL11, CCL22, CCR4, IGHE
8folliculitis10.5CCL11
9eosinophilic fasciitis10.5IL5
10eosinophilia-myalgia syndrome10.5IL5
11periapical granuloma10.5IL4
12malaria10.5IFNG
13aspergillosis10.4IFNG
14eczema herpeticum10.4IGHE
15allergic contact dermatitis10.3CCR4, IL5
16chronic eosinophilic pneumonia10.3CCL11, IL5
17pleurisy10.3MUC16
18giant papillary conjunctivitis10.3IL5, CCL11
19eosinophilic esophagitis10.3CCL11, IL5
20hypereosinophilic syndrome10.3IL3, IL5
21strongyloidiasis10.3IL5, IGHE
22leprosy10.3IL2
23dermatographia10.3IGHE, PRG2
24pulmonary fibrosis10.3PRG2, CCR4, CCL22
25helminthiasis10.3IGHE, IL5
26paragonimiasis10.3IGHE, IL5
27spiradenoma10.3MUC5AC, CCL11
28pneumonia10.3CCL22, CCL11, IL5
29filariasis10.3IGHE, IL5
30esophagitis10.2PRG2, CCL11, IL5
31mastocytosis10.2IGHE, IL5
32angioedema10.2IL5, IGHE
33immunodeficiency with hyper igm type 110.2IGHE, IL4
34cystadenocarcinoma10.2MUC5AC, MUC16
35visceral leishmaniasis10.2IFNG, IL4
36chronic obstructive pulmonary disease10.2CCL11, CCR4, MUC5AC
37cervical adenocarcinoma10.2MUC5AC, MUC16
38kimura disease10.2IGHE, PRG2, IL5
39idiopathic pulmonary fibrosis10.2CCR4, CCL22, IFNG
40contact dermatitis10.2IGHE, CCR4, IL5
41urticaria10.2PRG2, IGHE
42alopecia10.2
43keratoconus10.2
44stevens-johnson syndrome10.2
45cicatricial pemphigoid10.2
46alopecia areata10.2
47corneal disease10.2
48herpes simplex10.2
49influenza10.2
50keratitis10.2

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to atopic keratoconjunctivitis

Symptoms for Atopic Keratoconjunctivitis

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Drugs & Therapeutics for Atopic Keratoconjunctivitis

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Drug clinical trials:

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Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

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Anatomical Context for Atopic Keratoconjunctivitis

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MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

32
Eye, Bone marrow, Bone

Animal Models for Atopic Keratoconjunctivitis or affiliated genes

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MGI Mouse Phenotypes related to Atopic Keratoconjunctivitis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00020069.1IL3, IL5, IL2, IFNG
2MP:00053818.3MUC5AC, IFNG, IL4, IL2, IL5
3MP:00053887.5PRG2, CCR4, CCL11, IFNG, IL4, IL2
4MP:00053767.0IGHE, MUC5AC, IFNG, IL4, IL2, IL5
5MP:00053976.6IGHE, PRG2, CCR4, CCL11, IFNG, IL4
6MP:00053876.1IL3, IGHE, MUC5AC, PRG2, CCR4, CCL11

Publications for Atopic Keratoconjunctivitis

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Articles related to Atopic Keratoconjunctivitis:

(show top 50)    (show all 76)
idTitleAuthorsYear
1
Central corneal thickness in patients with atopic keratoconjunctivitis. (25240805)
2014
2
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. (23949491)
2013
3
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? (23106347)
2013
4
Atopic keratoconjunctivitis: A review. (24342754)
2013
5
Atopic keratoconjunctivitis. (23406935)
2013
6
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. (22378107)
2012
7
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. (22441637)
2012
8
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. (22275342)
2012
9
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. (22486642)
2012
10
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. (22717457)
2012
11
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. (22606467)
2011
12
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. (20861732)
2011
13
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. (21541276)
2011
14
Systemic cyclosporin A in severe atopic keratoconjunctivitis. (20491051)
2010
15
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. (20657166)
2010
16
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. (20482394)
2010
17
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. (18721214)
2009
18
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). (19693288)
2009
19
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (18584874)
2008
20
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. (18614131)
2008
21
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. (18782111)
2008
22
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. (17768384)
2007
23
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. (17893528)
2007
24
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. (16680103)
2007
25
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. (16490512)
2006
26
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. (16371796)
2006
27
Dramatic healing of an allergic corneal ulcer persistent for 6 months by amniotic membrane patching in a patient with atopic keratoconjunctivitis: a case report. (15448501)
2004
28
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis. (15548799)
2004
29
A randomized trial of topical cyclosporin 0.05% in topical steroid-resistant atopic keratoconjunctivitis. (15019322)
2004
30
Human mast cell subtypes in conjunctiva of patients with atopic keratoconjunctivitis, ocular cicatricial pemphigoid and Stevens-Johnson syndrome. (14566647)
2003
31
Toxic eosinophil granule protein deposition in corneal ulcerations and scars associated with atopic keratoconjunctivitis. (12470748)
2002
32
Topical cyclosporine A (2%) eyedrops in the therapy of atopic keratoconjunctivitis and keratoconjunctivitis vernalis. (12613996)
2002
33
The immunomodulatory effect of topical cyclosporin A in atopic keratoconjunctivitis. (9950598)
1999
34
Presence of eotaxin in tears of patients with atopic keratoconjunctivitis with severe corneal damage. (10359913)
1999
35
Analysis of tears in patients with atopic keratoconjunctivitis, using flow cytometry. (9483587)
1998
36
Long-term follow-up of patients with atopic keratoconjunctivitis. (9544637)
1998
37
A randomized, placebo-controlled trial of topical cyclosporin A in steroid-dependent atopic keratoconjunctivitis. (9754182)
1998
38
Further studies on the immunopathology of atopic keratoconjunctivitis using flow cytometry. (9441704)
1997
39
Atopic keratoconjunctivitis. (9269601)
1997
40
Systemic cyclosporine A in severe atopic keratoconjunctivitis. (9261317)
1997
41
Penetrating keratoplasty in atopic keratoconjunctivitis. (8575184)
1995
42
Atopic keratoconjunctivitis. (22823113)
1994
43
Successful penetrating keratoplasty in a patient with severe atopic keratoconjunctivitis and elevated serum IgE level treated with long-term topical cyclosporin A. (7842716)
1994
44
Atopic keratoconjunctivitis (AKC). (8344185)
1993
45
Conjunctival epithelial cell hypermitosis and goblet cell hyperplasia in atopic keratoconjunctivitis. (8213976)
1993
46
Atopic keratoconjunctivitis. (1976238)
1990
47
Plasmapheresis treatment in patients with severe atopic keratoconjunctivitis. (3174011)
1988
48
Atopic keratoconjunctivitis. (13411162)
1957
49
Atopic keratoconjunctivitis. (13065376)
1953
50
Atopic keratoconjunctivitis. (13102561)
1952

Variations for Atopic Keratoconjunctivitis

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Expression for genes affiliated with Atopic Keratoconjunctivitis

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Expression patterns in normal tissues for genes affiliated with Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for genes affiliated with Atopic Keratoconjunctivitis

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Pathways related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 36)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.8IL5, IL4
2
Show member pathways
Development Thrombopoetin signaling via JAK STAT pathway60
9.7IFNG, IL4
39.7IFNG, IL2
49.7IFNG, IL2
5
Show member pathways
9.7IL2, IFNG
69.5IL5, IL4, CCL11
79.5IL4, IL5, IL3
8
Show member pathways
9.5IL3, IL5, IL2
9
Show member pathways
9.5CCR4, CCL22, CCL11
10
Show member pathways
9.5CCL11, CCL22, CCR4
119.4IL3, IL2, IL4
12
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.4IL4, IFNG, CCL11
139.3IFNG, IL4, IL2
14
Show member pathways
Immune response IL 12 induced IFN gamma production60
9.3IL2, IL4, IFNG
15
Show member pathways
9.3IL2, IL4, IFNG
16
Show member pathways
9.1IFNG, IL2, IL5, IL3
17
Show member pathways
9.1IFNG, IL4, IL2, IL5
189.1IFNG, IL4, IL2, IL5
199.1IFNG, IL4, IL2, IL5
209.1IFNG, IL4, IL2, IL5
219.1IL5, IL2, IL4, IFNG
22
Show member pathways
BCR signaling pathway37
TCR Signaling Pathway37
9.1IFNG, IL4, IL2, IL5
23
Show member pathways
Immune response CD16 signaling in NK cells60
9.0IL3, IL2, IL4, IFNG
24
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
9.0IL4, CCL11, IGHE
25
Show member pathways
8.9PRG2, CCR4, CCL22, CCL11
268.7IFNG, IL4, IL2, IL5, IL3
27
Show member pathways
Calcium signaling in the CD4+ TCR pathway37
8.7IFNG, IL4, IL2, IL5, IL3
28
Show member pathways
Type III interferon signaling37
8.7IL3, IL5, IL2, IL4, IFNG
298.7IGHE, CCL11, IL4, IL5
30
Show member pathways
Immune response BCR pathway60
Fc-epsilon receptor I signaling in mast cells37
8.7IGHE, IL4, IL5, IL3
31
Show member pathways
8.2CCL22, CCL11, IFNG, IL4, IL2, IL5
32
Show member pathways
8.1IL5, IL2, IL4, CCL11, CCL22, CCR4
33
Show member pathways
8.1CCR4, CCL22, CCL11, IL4, IL2, IL5
34
Show member pathways
7.9IL3, IL5, IL2, IL4, IFNG, CCL11
35
Show member pathways
7.7CCR4, CCL22, CCL11, IFNG, IL4, IL2
36
Show member pathways
7.6PRG2, CCR4, CCL22, CCL11, IL4, IL2

Compounds for genes affiliated with Atopic Keratoconjunctivitis

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Compounds related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show top 50)    (show all 155)
idCompoundScoreTop Affiliating Genes
1salmeterol44 50 28 1112.6IL4, IL5, IL2, CCL11
2interferon gamma449.5IL4, IL2, IFNG
3glatiramer acetate44 1110.4IL4, IFNG, IL2, IL5
4il-12449.4IFNG, IL5, IL2, IL4
5con a449.4IL2, IL4, IFNG, IL5
6ltc4449.4CCL11, IL3, PRG2, IL5
7rolipram44 61 2811.4CCL11, IFNG, IL4, IL5
8polyinosinic-polycytidylic acid449.4IL5, IL4, IL2, IFNG
9unicap449.3IGHE, IL5, CCL11
10omalizumab44 1110.3IL4, IGHE, IL5
11methylcellulose449.3IFNG, IL4, IL5, IL3
12oxatomide449.3IGHE, IL5, IL3
13poly(i-c)449.2CCL11, IL4, IFNG, IL5, IL3
14gm-csf44 2810.2IL3, IL4, IL2, IL5, IFNG
15il 10449.1IL3, IL4, IFNG, IL2, IL5
16nedocromil sodium449.1IGHE, IL4, IL5, IL3
17ribavirin44 50 1111.1IL2, IL4, IFNG, IL3
18azelastine44 1110.1IL5, IGHE, IL4, IL3
19itraconazole44 1110.1IGHE, IL4, IL5, IL3
20montelukast44 50 28 1112.1IGHE, CCL11, IL4, IL5
21ccl344 2810.0IFNG, CCR4, CCL22, CCL11
22ovomucoid448.9IGHE, IL5, IL4
23melphalan44 50 1110.9IFNG, MUC16, IL4, IL3
24herbimycin a44 619.9IL4, IL3, IL5, IFNG, CCL11, IL2
25ionomycin448.8IFNG, CCL11, IL3, IL5, IL4, IL2
26pgd2448.8CCL11, PRG2, IGHE, IL5
27budesonide44 50 1110.7IL5, IL4, CCL11, IFNG, IGHE
28fluticasone propionate44 50 61 1111.7IL4, CCL11, IGHE, IFNG, IL5
29ivig448.7IGHE, IFNG, IL5, IL3, IL4
30tacrolimus44 50 1110.6IL4, IL3, IL2, CCL22, IL5, IFNG
31sb 20358044 619.6MUC5AC, CCL11, IL5, IL4, IFNG, CCL22
32thymidine44 249.6IL5, IL2, CCL11, IFNG, IL4, IL3
33genistein44 28 61 2 24 1113.6PRG2, IL3, CCL11, IFNG, IL2, IL5
34methacholine44 50 1110.4IL5, IL4, CCL11, CCL22, PRG2, IGHE
35cyclophosphamide44 50 1110.4IL4, IL2, MUC16, IL3, IGHE
36hydrocortisone44 2 61 1111.3IGHE, IFNG, IL4, IL5, IL3, IL2
37pge2448.3IL4, IL5, IL2, MUC5AC, CCL22, CCL11
38allergens448.2IFNG, PRG2, IL5, IL4, IGHE, CCL11
39rantes448.2IL5, IL2, CCL22, IFNG, CCL11, CCR4
40tarc448.0CCL22, IFNG, IL5, IL4, CCL11, CCR4
41indomethacin44 28 61 1110.8IFNG, IL4, IGHE, PRG2, CCL11, IL2
42actinomycin d447.8IFNG, IL4, IL3, IL2, CCL11, PRG2
43cyclosporin a44 28 619.8IFNG, IL2, IL5, IL3, CCL22, IGHE
44prednisolone44 28 119.7IFNG, CCR4, IL2, IL5, CCL11, IGHE
45vegf447.7CCL11, IL5, IL4, IFNG, MUC16, IL2
46cycloheximide447.6IL3, IL2, IL4, IFNG, IGHE, IL5
47retinoic acid44 248.1CCL11, CCR4, PRG2, IL3, MUC5AC, IGHE
48tyrosine447.1CCR4, MUC16, IL5, IL2, IL4, CCL11
49histamine44 28 248.7CCL22, CCL11, IL3, IL5, IL2, IGHE
50dexamethasone44 50 28 119.7IL5, IL4, IFNG, MUC5AC, CCL11, CCL22

GO Terms for genes affiliated with Atopic Keratoconjunctivitis

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Cellular components related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL4, IFNG, CCR4
2extracellular spaceGO:0056157.6IL3, MUC16, CCL22, CCL11, IFNG, IL4
3extracellular regionGO:0055766.9IGHE, PRG2, CCL22, CCL11, IFNG, IL2

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1positive regulation of immunoglobulin secretionGO:05102410.0IL5, IL2
2positive regulation of MHC class II biosynthetic processGO:0453489.9IL4, IFNG
3positive regulation of chemokine biosynthetic processGO:0450809.9IFNG, IL4
4defense response to protozoanGO:0428329.8IFNG, IL4
5positive regulation of activated T cell proliferationGO:0421049.8IL2, IL4
6positive regulation of B cell proliferationGO:0308909.7IL4, IL2, IL5
7positive regulation of T cell proliferationGO:0421029.7IL4, IFNG
8response to radiationGO:0093149.7CCL11, CCR4
9positive regulation of tyrosine phosphorylation of Stat5 proteinGO:0425239.7IL4, IL2, IL3
10response to virusGO:0096159.6IFNG, CCL11, CCL22
11positive regulation of isotype switching to IgG isotypesGO:0483049.6IL2, IL4, IFNG
12extrinsic apoptotic signaling pathway in absence of ligandGO:0971929.5IL2, IL4
13cell-cell signalingGO:0072679.4CCL22, IL2, IL3
14inflammatory responseGO:0069549.4CCR4, CCL22, CCL11, IL5
15chemotaxisGO:0069359.4IL4, CCL11, CCL22, CCR4
16immune responseGO:0069557.1IL3, IGHE, PRG2, CCR4, CCL22, CCL11

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:0080099.9CCL11, CCL22
2growth factor activityGO:0080838.9IL4, IL2, IL5, IL3
3cytokine activityGO:0051258.6IL3, IL5, IL2, IL4, IFNG

Products for genes affiliated with Atopic Keratoconjunctivitis

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  • Antibodies
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Sources for Atopic Keratoconjunctivitis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet