MCID: ATP013
MIFTS: 41

Atopic Keratoconjunctivitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

MalaCards integrated aliases for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 56 69

Characteristics:

Orphanet epidemiological data:

56
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA163934
UMLS via Orphanet 70 C1274788
ICD10 via Orphanet 34 H16.2

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to myoclonic astatic epilepsy and eye accommodation disease, and has symptoms including dry skin, keratoconjunctivitis sicca and corneal opacity. An important gene associated with Atopic Keratoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Miconazole and Antifungal Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and t cells.

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
id Related Disease Score Top Affiliating Genes
1 myoclonic astatic epilepsy 10.8 IFNG IL4
2 eye accommodation disease 10.8 IFNG IL4
3 thelaziasis 10.7 IFNG IL4
4 gastroschisis 10.7 IFNG IL5
5 goat milk allergy 10.7 IFNG IL4
6 visual snow syndrome 10.7 IL2 IL4
7 angioid streaks of choroid 10.7 IL4 IL5
8 bulbospinal polio 10.7 IFNG IL2
9 allescheriosis 10.7 IL4 IL5
10 urethral intrinsic sphincter deficiency 10.7 IL4 IL5
11 keratoconjunctivitis 10.7
12 autoimmune polyglandular syndrome type 3 10.7 IFNG IL2
13 centronuclear myopathy 5 10.7 IFNG IL4
14 anthracosilicosis 10.7 IFNG IL2
15 graft-versus-host disease, protection against 10.7 IFNG IL2
16 epididymis adenocarcinoma 10.7 IL4 IL5
17 pmm2-congenital disorder of glycosylation 10.7 IL2 IL4
18 cholesteatoma of middle ear 10.7 IFNG IL5
19 oropharyngeal cancer, childhood 10.7 IFNG IL4
20 hypereosinophilic syndrome 10.7 IFNG IL5
21 histoplasmosis retinitis 10.6 IL4 IL5
22 abdominal tuberculosis 10.6 IL4 IL5
23 plantar wart 10.6 IFNG IL2
24 sideroblastic anemia 10.6 IL3 IL5
25 nonspecific interstitial pneumonia 10.6 CCL22 IL5
26 hemangioma of spleen 10.6 IFNG IL5
27 spindle cell hemangioma 10.6 IFNG IL4
28 amyotrophic lateral sclerosis type 10 10.6 IFNG IL2
29 glucose intolerance 10.6 IL4 IL5
30 wilms tumor 6 10.6 IL3 IL5
31 anterior dislocation of lens 10.6 IL4 RNASE3
32 parametritis 10.6 IFNG IL2
33 papillary follicular thyroid adenocarcinoma 10.6 IL5 RNASE3
34 chronic graft versus host disease 10.6 IFNG IL2
35 multiple congenital anomalies mental retardation, growth failure and cleft lip palate 10.6 IFNG IL5
36 toxic diffuse goiter 10.5 IL5 RNASE3
37 crustacean allergy 10.5 IL5 RNASE3
38 philophthalmiasis 10.5 IL4 IL5
39 sternal cleft 10.5 IFNG IGHE
40 childhood brain stem glioma 10.5 IFNG IL4
41 early-onset zonular cataract 10.5 IFNG IL4
42 sparse hair ptosis mental retardation 10.5 IFNG IL3
43 fibrous histiocytoma 10.5 IFNG IL4 IL5
44 subacute bacterial endocarditis 10.5 IL5 RNASE3
45 loiasis 10.5 IFNG IL4 IL5
46 hypoparathyroidism, x-linked 10.5 IGHE IL4
47 cannabis abuse 10.5 IL5 RNASE3
48 cyclosporiasis 10.5 IFNG IL2
49 lymphocytic colitis 10.5 IFNG IL2 IL4
50 tularemia 10.5 IFNG IL2 IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

56 32 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 56 32 hallmark (90%) Very frequent (99-80%) HP:0000958
2 keratoconjunctivitis sicca 56 32 hallmark (90%) Very frequent (99-80%) HP:0001097
3 corneal opacity 56 32 hallmark (90%) Very frequent (99-80%) HP:0007957
4 blepharitis 56 32 frequent (33%) Frequent (79-30%) HP:0000498
5 loss of eyelashes 56 32 frequent (33%) Frequent (79-30%) HP:0011457
6 corneal neovascularization 56 32 frequent (33%) Frequent (79-30%) HP:0011496
7 chemosis 56 32 occasional (7.5%) Occasional (29-5%) HP:0012375
8 keratitis 56 Very frequent (99-80%)
9 abnormality of the eyelid 56 Frequent (79-30%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
2 Antifungal Agents Phase 3
3 Anti-Infective Agents Phase 3
4 Antirheumatic Agents Phase 3
5 Calcineurin Inhibitors Phase 3
6 Cyclosporins Phase 3
7 Dermatologic Agents Phase 3
8 Immunosuppressive Agents Phase 3
9 Ophthalmic Solutions Phase 3
10 Pharmaceutical Solutions Phase 3
11 Tetrahydrozoline

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3 Cyclosporine Vehicle;Cyclosporine 0.010%
2 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467 Cyclosporin 0.05% ophthalmic;Cyclosporin 0.05% ophthalmic

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

39
Eye, Skin, T Cells, Bone, Bone Marrow

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 88)
id Title Authors Year
1
Expression of IL-33 in ocular surface epithelium induces atopic keratoconjunctivitis with activation of group 2 innate lymphoid cells in mice. ( 28855579 )
2017
2
Ocular Surface Squamous Neoplasia Associated with Atopic Keratoconjunctivitis. ( 28275599 )
2017
3
Atopic keratoconjunctivitis complicated by Kocuria koreensis keratitis: the first case. ( 28138334 )
2017
4
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. ( 27901637 )
2016
5
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
6
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. ( 28076564 )
2016
7
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. ( 25923050 )
2015
8
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. ( 25682856 )
2015
9
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. ( 26278858 )
2015
10
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. ( 26302769 )
2015
11
Central corneal thickness in patients with atopic keratoconjunctivitis. ( 25240805 )
2014
12
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. ( 24439439 )
2014
13
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. ( 25705372 )
2014
14
Functional visual acuity assessment of severe atopic keratoconjunctivitis. ( 25289719 )
2014
15
Atopic keratoconjunctivitis: A review. ( 24342754 )
2013
16
Atopic keratoconjunctivitis. ( 23406935 )
2013
17
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? ( 23106347 )
2013
18
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. ( 23886231 )
2013
19
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. ( 23949491 )
2013
20
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. ( 22717457 )
2012
21
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. ( 22378107 )
2012
22
Atopic keratoconjunctivitis: present day diagnosis. ( 22872669 )
2012
23
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. ( 22581322 )
2012
24
Topical cyclosporine for atopic keratoconjunctivitis. ( 22972132 )
2012
25
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. ( 22275342 )
2012
26
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. ( 22092652 )
2012
27
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. ( 22441637 )
2012
28
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. ( 22486642 )
2012
29
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. ( 21541276 )
2011
30
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. ( 22606467 )
2011
31
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. ( 20861732 )
2011
32
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. ( 20482394 )
2010
33
Omalizumab for severe atopic keratoconjunctivitis. ( 22791726 )
2010
34
Atopic keratoconjunctivitis and atopic dermatitis. ( 20720488 )
2010
35
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. ( 20657166 )
2010
36
Systemic cyclosporin A in severe atopic keratoconjunctivitis. ( 20491051 )
2010
37
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). ( 19693288 )
2009
38
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. ( 18721214 )
2009
39
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. ( 18614131 )
2008
40
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 18584874 )
2008
41
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. ( 18782111 )
2008
42
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. ( 18724148 )
2008
43
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. ( 17893528 )
2007
44
Clinical grading of atopic keratoconjunctivitis. ( 17873586 )
2007
45
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 17768384 )
2007
46
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. ( 17620070 )
2007
47
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. ( 16680103 )
2007
48
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. ( 16490512 )
2006
49
Systemic tacrolimus in the treatment of severe atopic keratoconjunctivitis. ( 17172887 )
2006
50
Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. ( 17177679 )
2006

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCL22 IFNG IGHE IL2 IL3 IL4
2
Show member pathways
13.48 CCL22 IFNG IL2 IL3 IL4 IL5
3
Show member pathways
13.36 CCL22 IFNG IL2 IL3 IL4 IL5
4
Show member pathways
13.19 CCL22 IFNG IGHE IL2 IL3 IL4
5
Show member pathways
13.12 CCL22 IL2 IL3 IL4 IL5
6
Show member pathways
12.61 IFNG IL2 IL3 IL4 IL5 PRG2
7
Show member pathways
12.5 IFNG IGHE IL2 IL4
8
Show member pathways
12.45 IFNG IL2 IL4 IL5
9
Show member pathways
12.44 IGHE IL3 IL4 IL5
10 12.39 IFNG IL2 IL3 IL4
11
Show member pathways
12.36 IFNG IL2 IL3 IL4
12
Show member pathways
12.29 IFNG IL2 IL4 IL5
13
Show member pathways
12.19 IFNG IL4 IL5 MUC5AC
14
Show member pathways
12.11 IFNG IL2 IL3 IL4 IL5
15
Show member pathways
12.04 IFNG IL2 IL3 IL4 IL5
16
Show member pathways
12.01 IL2 IL3 IL5
17 11.89 IFNG IL2 IL4
18 11.87 IFNG IL2 IL3 IL4 IL5
19 11.86 CCL22 IGHE IL4
20
Show member pathways
11.85 IFNG IL2 IL4
21 11.76 IFNG IL2 IL3
22 11.76 IL3 IL4 IL5
23 11.74 IFNG IL2 IL4 IL5
24 11.71 IFNG IL2 IL4 IL5
25 11.54 IGHE IL4 IL5
26
Show member pathways
11.43 IFNG IL2 IL3 IL4 IL5
27 11.23 IFNG IL4 IL5
28 11.19 IFNG IL2 IL4 IL5
29 11.12 CCL22 IL2 IL3 IL4 IL5
30 11.1 IFNG IL2
31 11.03 CCL22 IFNG IL2 IL4 IL5
32 10.97 IFNG IL2 IL4 IL5
33 10.79 IL4 IL5
34 10.5 IFNG IL2 IL3 IL4 IL5

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL22 IFNG IL2 IL3 IL4 IL5
2 extracellular region GO:0005576 9.36 CCL22 IFNG IGHE IL2 IL3 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of GTPase activity GO:0043547 9.88 CCL22 IL2 IL3 IL5
2 positive regulation of cell proliferation GO:0008284 9.8 IFNG IL2 IL3 IL4 IL5
3 positive regulation of protein phosphorylation GO:0001934 9.71 IFNG IL2 IL4
4 defense response to bacterium GO:0042742 9.67 IFNG IGHE PRG2 RNASE3
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.65 IL3 IL4 IL5
6 positive regulation of T cell proliferation GO:0042102 9.61 IFNG IL2 IL4
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.58 IL2 IL4
8 positive regulation of activated T cell proliferation GO:0042104 9.57 IL2 IL4
9 innate immune response in mucosa GO:0002227 9.56 IL4 RNASE3
10 defense response to protozoan GO:0042832 9.55 IFNG IL4
11 positive regulation of T cell differentiation GO:0045582 9.52 IL2 IL4
12 positive regulation of immunoglobulin secretion GO:0051024 9.51 IL2 IL5
13 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IFNG IL4
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IFNG IL4
15 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.46 IFNG IL2 IL3 IL4
16 positive regulation of B cell proliferation GO:0030890 9.43 IL2 IL4 IL5
17 negative regulation of T-helper 17 cell differentiation GO:2000320 9.32 IL2 IL4
18 immune response GO:0006955 9.23 CCL22 IFNG IGHE IL2 IL3 IL4
19 positive regulation of isotype switching to IgG isotypes GO:0048304 9.13 IFNG IL2 IL4

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 IL2 IL3 IL5
2 growth factor activity GO:0008083 9.26 IL2 IL3 IL4 IL5
3 cytokine activity GO:0005125 9.1 CCL22 IFNG IL2 IL3 IL4 IL5

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
Content
Loading form....