MCID: ATP013
MIFTS: 40

Atopic Keratoconjunctivitis malady

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Atopic Keratoconjunctivitis

Aliases & Descriptions for Atopic Keratoconjunctivitis:

Name: Atopic Keratoconjunctivitis 56 69

Characteristics:

Orphanet epidemiological data:

56
atopic keratoconjunctivitis
Prevalence: 1-5/10000 (Europe);

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 56  
Rare eye diseases


External Ids:

Orphanet 56 ORPHA163934
UMLS via Orphanet 70 C1274788
ICD10 via Orphanet 34 H16.2

Summaries for Atopic Keratoconjunctivitis

MalaCards based summary : Atopic Keratoconjunctivitis is related to keratoconjunctivitis and myoglobinuria recurrent, and has symptoms including dry skin, keratoconjunctivitis sicca and corneal opacity. An important gene associated with Atopic Keratoconjunctivitis is IL4 (Interleukin 4), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Cyclosporine and Miconazole have been mentioned in the context of this disorder. Affiliated tissues include eye, skin and t cells.

Related Diseases for Atopic Keratoconjunctivitis

Diseases related to Atopic Keratoconjunctivitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 155)
id Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 10.7
2 myoglobinuria recurrent 10.3 IFNG IL4
3 asymptomatic neurosyphilis 10.3 IFNG IL4
4 gastroschisis abdominal wall defects, included 10.3 IFNG IL5
5 sarcoma 10.3 IL2 IL4
6 vulvar vestibulitis syndrome 10.3 IL2 IL4
7 tungiasis 10.3 IFNG IL4
8 crustacean allergy 10.3 IFNG IL4
9 paralytic poliomyelitis 10.3 IFNG IL2
10 caplan's syndrome 10.3 IFNG IL2
11 severe combined immunodeficiency, t cell-negative, b-cell/natural killer-cell positive 10.3 IFNG IL2
12 hypersensitivity vasculitis 10.3 IL4 IL5
13 albinism 10.3 IFNG IL5
14 choledochal cyst 10.3 IL3 IL5
15 lymphoblastic leukemia 10.3 IL4 IL5
16 cataract, total congenital 10.3 IFNG IL5
17 spastic diplegia 10.3 IFNG IL5
18 allescheriosis 10.2 IL4 IL5
19 bone peripheral neuroepithelioma 10.2 IL4 IL5
20 centronuclear myopathy 5 10.2 IFNG IL4
21 kahrizi syndrome 10.2 IL3 IL5
22 restrictive cardiomyopathy 10.2 IL5 RNASE3
23 middle lobe syndrome 10.2 CCL22 IL5
24 anterior dislocation of lens 10.2 IL4 RNASE3
25 lactose intolerance 10.2 IL4 IL5
26 plantar wart 10.2 IFNG IL2
27 renal hypertension 10.2 IL5 RNASE3
28 urethral intrinsic sphincter deficiency 10.2 IFNG IL4 IL5
29 stocco dos santos syndrome 10.2 IFNG IGHE
30 cutaneous fibrous histiocytoma 10.2 IFNG IL4 IL5
31 brown shrimp allergy 10.2 IL5 RNASE3
32 autosomal dominant deafness-onychodystrophy syndrome 10.2 IFNG IL2 IL4
33 hemangioma of spleen 10.2 IFNG IL5
34 loiasis 10.2 IFNG IL4 IL5
35 clostridium difficile colitis 10.2 IFNG IL2 IL4
36 tularemia 10.2 IFNG IL2 IL4
37 balkan nephropathy 10.2 IFNG IL4 IL5
38 inflammatory bowel disease 2 10.2 IFNG IL4 IL5
39 thelaziasis 10.2 IL2 IL4 IL5
40 acute myeloid leukemia with recurrent genetic anomaly 10.2 IFNG IL2 IL4
41 orbital osteomyelitis 10.2 IFNG IL2 IL4
42 parasitic protozoa infectious disease 10.2 IFNG IL4 IL5
43 myiasis 10.2 IFNG IL2 IL4
44 nasopharyngitis 10.2 IFNG IL2 IL4
45 eye carcinoma in situ 10.2 IFNG IL2 IL4
46 latent syphilis 10.2 IL5 RNASE3
47 liver inflammatory pseudotumor 10.2 IFNG IL2 IL4
48 erythematosquamous dermatosis 10.2 IFNG IL4 IL5
49 blue toe syndrome 10.2 IFNG IL2 IL4
50 nonspecific interstitial pneumonia 10.2 IFNG IL2 IL4

Graphical network of the top 20 diseases related to Atopic Keratoconjunctivitis:



Diseases related to Atopic Keratoconjunctivitis

Symptoms & Phenotypes for Atopic Keratoconjunctivitis

Human phenotypes related to Atopic Keratoconjunctivitis:

56 32 (show all 9)
id Description HPO Frequency Orphanet Frequency HPO Source Accession
1 dry skin 56 32 Very frequent (99-80%) HP:0000958
2 keratoconjunctivitis sicca 56 32 Very frequent (99-80%) HP:0001097
3 corneal opacity 56 32 Very frequent (99-80%) HP:0007957
4 blepharitis 56 32 Frequent (79-30%) HP:0000498
5 loss of eyelashes 56 32 Frequent (79-30%) HP:0011457
6 corneal neovascularization 56 32 Frequent (79-30%) HP:0011496
7 chemosis 56 32 Occasional (29-5%) HP:0012375
8 keratitis 56 Very frequent (99-80%)
9 abnormality of the eyelid 56 Frequent (79-30%)

Drugs & Therapeutics for Atopic Keratoconjunctivitis

Drugs for Atopic Keratoconjunctivitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyclosporine Approved, Investigational, Vet_approved Phase 3 79217-60-0, 59865-13-3 5284373 6435893
2
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
3 Dermatologic Agents Phase 3
4 Ophthalmic Solutions Phase 3
5 Pharmaceutical Solutions Phase 3
6 Anti-Infective Agents Phase 3
7 Immunosuppressive Agents Phase 3
8 Antifungal Agents Phase 3
9 Antirheumatic Agents Phase 3
10 Calcineurin Inhibitors Phase 3
11 Tetrahydrozoline

Interventional clinical trials:


id Name Status NCT ID Phase
1 Efficacy and Safety Study of Cyclosporine 0.010% to Treat Atopic Keratoconjunctivitis Completed NCT00884585 Phase 3
2 Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis Completed NCT00987467

Search NIH Clinical Center for Atopic Keratoconjunctivitis

Genetic Tests for Atopic Keratoconjunctivitis

Anatomical Context for Atopic Keratoconjunctivitis

MalaCards organs/tissues related to Atopic Keratoconjunctivitis:

39
Eye, Skin, T Cells, Bone, Bone Marrow

Publications for Atopic Keratoconjunctivitis

Articles related to Atopic Keratoconjunctivitis:

(show top 50) (show all 85)
id Title Authors Year
1
Clinical Usefulness of Monitoring Expression Levels of CCL24 (Eotaxin-2) mRNA on the Ocular Surface in Patients with Vernal Keratoconjunctivitis and Atopic Keratoconjunctivitis. ( 27721987 )
2016
2
Angiographic Evaluation of Inflammation in Atopic Keratoconjunctivitis. ( 27901637 )
2016
3
Atopic keratoconjunctivitis: long-term results of medical treatment and penetrating keratoplasty. ( 28076564 )
2016
4
Involvement of Chemokines and a CD4-Positive T Cell Subset in the Development of Conjunctival Secondary Lymphoid Follicles in an Atopic Keratoconjunctivitis Mouse Model. ( 26302769 )
2015
5
Spontaneous corneal perforation associated with atopic keratoconjunctivitis: a case series and literature review. ( 25682856 )
2015
6
Candida albicans should be considered when managing keratitis in Atopic keratoconjunctivitis. ( 25923050 )
2015
7
Atopic Keratoconjunctivitis in Children: Clinical Features and Diagnosis. ( 26278858 )
2015
8
Functional visual acuity assessment of severe atopic keratoconjunctivitis. ( 25289719 )
2014
9
Downregulation of IL-8, ECP, and total IgE in the tears of patients with atopic keratoconjunctivitis treated with rebamipide eyedrops. ( 25705372 )
2014
10
Central corneal thickness in patients with atopic keratoconjunctivitis. ( 25240805 )
2014
11
Long-term follow-up of tacrolimus ointment for treatment of atopic keratoconjunctivitis. ( 24439439 )
2014
12
Atopic keratoconjunctivitis: A review. ( 24342754 )
2013
13
Chemotactic responses of peripheral blood eosinophils to prostaglandin D2 in atopic keratoconjunctivitis. ( 23886231 )
2013
14
Atopic keratoconjunctivitis. ( 23406935 )
2013
15
Surgical treatment of 32 cases of long-term atopic keratoconjunctivitis using the amniotic membrane. ( 23949491 )
2013
16
Treatment of atopic keratoconjunctivitis in patients with atopic dermatitis: is ocular application of tacrolimus an option? ( 23106347 )
2013
17
Conjunctival provocation with airborne allergen in patients with atopic keratoconjunctivitis. ( 22092652 )
2012
18
Topical cyclosporine for atopic keratoconjunctivitis. ( 22972132 )
2012
19
Atopic keratoconjunctivitis: present day diagnosis. ( 22872669 )
2012
20
The role of Staphylococcal enterotoxin in atopic keratoconjunctivitis and corneal ulceration. ( 22486642 )
2012
21
In vivo confocal microscopy evaluation of meibomian gland dysfunction in atopic-keratoconjunctivitis patients. ( 22717457 )
2012
22
Ocular surface squamous neoplasia in an immunosuppressed patient with atopic keratoconjunctivitis. ( 22581322 )
2012
23
Evaluation of eosinophilic inflammation in a novel murine atopic keratoconjunctivitis model induced by crude Dermatophagoides farinae antigen. ( 22441637 )
2012
24
Topical calcineurin inhibitors in the treatment of steroid-dependent atopic keratoconjunctivitis. ( 22378107 )
2012
25
IgE and eosinophil cationic protein (ECP) as markers of severity in the diagnosis of atopic keratoconjunctivitis. ( 22275342 )
2012
26
Limbitis secondary to autologous serum eye drops in a patient with atopic keratoconjunctivitis. ( 22606467 )
2011
27
Eosinophil cationic protein as a marker for assessing the efficacy of tacrolimus ophthalmic solution in the treatment of atopic keratoconjunctivitis. ( 21541276 )
2011
28
Topical tacrolimus ointment for treatment of intractable atopic keratoconjunctivitis: a case report and review of the literature. ( 20861732 )
2011
29
Pellucid marginal corneal disease in a case of atopic keratoconjunctivitis. ( 20482394 )
2010
30
Systemic cyclosporin A in severe atopic keratoconjunctivitis. ( 20491051 )
2010
31
Case report of restoration of the corneal epithelium in a patient with atopic keratoconjunctivitis resulting in amelioration of ocular allergic inflammation. ( 20657166 )
2010
32
Omalizumab for severe atopic keratoconjunctivitis. ( 22791726 )
2010
33
Atopic keratoconjunctivitis and atopic dermatitis. ( 20720488 )
2010
34
Dramatic improvement of atopic keratoconjunctivitis after topical treatment with tacrolimus ointment restricted to the eyelids. ( 18721214 )
2009
35
Evaluation of conjunctival inflammatory status by confocal scanning laser microscopy and conjunctival brush cytology in patients with atopic keratoconjunctivitis (AKC). ( 19693288 )
2009
36
Corneal in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 18584874 )
2008
37
Use of systemic T-lymphocyte signal transduction inhibitors in the treatment of atopic keratoconjunctivitis. ( 18724148 )
2008
38
Acquisition of vernal and atopic keratoconjunctivitis after bone marrow transplantation. ( 18614131 )
2008
39
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. ( 18782111 )
2008
40
Tacrolimus ointment vs steroid ointment for eyelid dermatitis in patients with atopic keratoconjunctivitis. ( 16680103 )
2007
41
The differences of tear function and ocular surface findings in patients with atopic keratoconjunctivitis and vernal keratoconjunctivitis. ( 17620070 )
2007
42
Role of rigid gas-permeable scleral contact lenses in the management of advanced atopic keratoconjunctivitis. ( 17893528 )
2007
43
Clinical grading of atopic keratoconjunctivitis. ( 17873586 )
2007
44
Conjunctival in vivo confocal scanning laser microscopy in patients with atopic keratoconjunctivitis. ( 17768384 )
2007
45
The impact of the onset time of atopic keratoconjunctivitis on the tear function and ocular surface findings. ( 16490512 )
2006
46
Bilateral infectious ulcers associated with atopic keratoconjunctivitis. ( 16371796 )
2006
47
Alterations of the ocular surface epithelial mucins 1, 2, 4 and the tear functions in patients with atopic keratoconjunctivitis. ( 17177679 )
2006
48
Systemic tacrolimus in the treatment of severe atopic keratoconjunctivitis. ( 17172887 )
2006
49
Chemokine receptor gene expression in giant papillae of atopic keratoconjunctivitis. ( 15788997 )
2005
50
Inflammatory cells in brush cytology samples correlate with the severity of corneal lesions in atopic keratoconjunctivitis. ( 15548799 )
2004

Variations for Atopic Keratoconjunctivitis

Expression for Atopic Keratoconjunctivitis

Search GEO for disease gene expression data for Atopic Keratoconjunctivitis.

Pathways for Atopic Keratoconjunctivitis

Pathways related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 34)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.79 CCL22 IFNG IGHE IL2 IL3 IL4
2
Show member pathways
13.36 CCL22 IFNG IL2 IL3 IL4 IL5
3
Show member pathways
13.2 CCL22 IFNG IGHE IL2 IL3 IL4
4
Show member pathways
13.12 CCL22 IL2 IL3 IL4 IL5
5
Show member pathways
12.61 IFNG IL2 IL3 IL4 IL5 PRG2
6
Show member pathways
12.5 IFNG IGHE IL2 IL4
7
Show member pathways
12.46 IFNG IL2 IL4 IL5
8
Show member pathways
12.44 IGHE IL3 IL4 IL5
9 12.39 IFNG IL2 IL3 IL4
10
Show member pathways
12.37 IFNG IL2 IL3 IL4
11
Show member pathways
12.3 IFNG IL2 IL4 IL5
12
Show member pathways
12.19 IFNG IL4 IL5 MUC5AC
13
Show member pathways
12.17 IFNG IL2 IL4
14
Show member pathways
12.11 IFNG IL2 IL3 IL4 IL5
15
Show member pathways
12.04 IFNG IL2 IL3 IL4 IL5
16
Show member pathways
12.01 IL2 IL3 IL5
17 11.89 IFNG IL2 IL4
18 11.87 IFNG IL2 IL3 IL4 IL5
19 11.86 CCL22 IGHE IL4
20
Show member pathways
11.85 IFNG IL2 IL4
21 11.77 IL3 IL4 IL5
22 11.74 IFNG IL2 IL4 IL5
23 11.71 IFNG IL2 IL4 IL5
24 11.58 IFNG IL2 IL3
25 11.54 IGHE IL4 IL5
26
Show member pathways
11.43 IFNG IL2 IL3 IL4 IL5
27 11.22 IFNG IL4 IL5
28 11.19 IFNG IL2 IL4 IL5
29 11.12 CCL22 IL2 IL3 IL4 IL5
30 11.1 IFNG IL2
31 11.03 CCL22 IFNG IL2 IL4 IL5
32 10.97 IFNG IL2 IL4 IL5
33 10.81 IL4 IL5
34 10.5 IFNG IL2 IL3 IL4 IL5

GO Terms for Atopic Keratoconjunctivitis

Cellular components related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.61 CCL22 IFNG IL2 IL3 IL4 IL5
2 extracellular region GO:0005576 9.36 CCL22 IFNG IGHE IL2 IL3 IL4

Biological processes related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

(show all 19)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.8 IFNG IL2 IL3 IL4 IL5
2 positive regulation of protein phosphorylation GO:0001934 9.73 IFNG IL2 IL4
3 defense response to bacterium GO:0042742 9.73 IFNG IGHE PRG2 RNASE3
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.67 IL3 IL4 IL5
5 positive regulation of T cell proliferation GO:0042102 9.63 IFNG IL2 IL4
6 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.58 IL2 IL4
7 positive regulation of activated T cell proliferation GO:0042104 9.58 IL2 IL4
8 innate immune response in mucosa GO:0002227 9.57 IL4 RNASE3
9 defense response to protozoan GO:0042832 9.55 IFNG IL4
10 positive regulation of T cell differentiation GO:0045582 9.54 IL2 IL4
11 positive regulation of immunoglobulin secretion GO:0051024 9.52 IL2 IL5
12 positive regulation of chemokine biosynthetic process GO:0045080 9.51 IFNG IL4
13 positive regulation of B cell proliferation GO:0030890 9.5 IL2 IL4 IL5
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.48 IFNG IL4
15 positive regulation of tyrosine phosphorylation of Stat5 protein GO:0042523 9.43 IL2 IL3 IL4
16 negative regulation of T-helper 17 cell differentiation GO:2000320 9.37 IL2 IL4
17 positive regulation of isotype switching to IgG isotypes GO:0048304 9.33 IFNG IL2 IL4
18 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 IFNG IL2 IL3 IL4
19 immune response GO:0006955 9.23 CCL22 IFNG IGHE IL2 IL3 IL4

Molecular functions related to Atopic Keratoconjunctivitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.33 IL2 IL3 IL5
2 growth factor activity GO:0008083 9.26 IL2 IL3 IL4 IL5
3 cytokine activity GO:0005125 9.1 CCL22 IFNG IL2 IL3 IL4 IL5

Sources for Atopic Keratoconjunctivitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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