ATOPY
MCID: ATP002
MIFTS: 52

Atopy (ATOPY) malady

Summaries for Atopy

Sources:
64Wikipedia, 47OMIM, 33MalaCards
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Wikipedia:64 Atopy (pron. {ay-top-pee}); Greek ἀτοπία - placelessness, out of place, special, unusual,... more...

MalaCards: Atopy is related to asthma and atopic dermatitis. An important gene associated with Atopy is HAVCR1 (hepatitis A virus cellular receptor 1), and among its related pathways are Allograft rejection and Immune response Fc epsilon RI pathway. The compounds histamine and tyrosine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and lung, and related mouse phenotypes are immune system and homeostasis/metabolism.

Description from OMIM:47 147050

Aliases & Classifications for Atopy

Sources:
47OMIM, 45Novoseek, 61UMLS
See all sources

Aliases & Descriptions:

atopy 47 45 61


Related Diseases for Atopy

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Atopy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 178)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.6CYSLTR1, RNASE3
2atopic dermatitis30.8TSLP, SPINK5, IL4, RNASE3, IL13
3allergic rhinitis30.6EPX, RNASE3, IL13, IL5, IL4R, IL4
4allergic asthma30.5IL5, IL9, IL4R, IL4, CMA1, PLA2G7
5cystic fibrosis30.4IL9, RNASE3, SCGB1A1
6allergic bronchopulmonary aspergillosis30.2IL5, IL4
7vernal keratoconjunctivitis30.1RNASE3, IL13, IL5, IL4, CMA1
8sinusitis30.1LTC4S, CYSLTR1, RNASE3, IL5
9urticaria30.1RNASE3, LTC4S
10tuberculosis30.1IL4, IL4R, EPX
11bronchiolitis30.0RNASE3, IL13, IL5, IL4R
12arthritis30.0IL4, IL13
13bronchitis30.0IL9, IL5, RNASE3
14chronic rhinitis30.0RNASE3
15mastocytosis29.8IL13, IL5, IL9, CMA1
16churg-strauss syndrome29.8CYSLTR1, RNASE3, IL5
17helminthiasis29.8IL5, IL13, RNASE3
18tetanus29.8IL4, IL9, IL5, IL13
19intrinsic asthma29.8RNASE3, IL5, IL4
20bronchopulmonary dysplasia29.8PLA2G7, RNASE3, SCGB1A1
21allergic contact dermatitis29.8IL5, IL4R
22alopecia10.2
23asthma 110.2
24alopecia areata10.2
25aspergillosis10.2
26pulmonary function10.2
27croup10.1
28lichen sclerosus10.1
29asthma 210.1
30familial mediterranean fever10.0
31ichthyosis vulgaris10.0
32hepatitis c10.0
33n syndrome10.0
34hepatitis a10.0
35stomatitis10.0
36hepatitis c virus10.0
37rhinitis10.0SCGB1A1, EPX, CYSLTR1, RNASE3, IL13, IL5
38eosinophilia10.0CD14, EPX, CYSLTR1, RNASE3, IL13, IL5
39cork-handlers' disease10.0SCGB1A1, LTC4S, CD14, RNASE3, IL13, IL5
40leukemia10.0SCGB1A1, LTC4S, CD14, EPX, RNASE3, IL9
41psoriasis10.0RNASE3, IL13, IL5, IL4R, IL4, CMA1
42ulcerative colitis10.0CD14, EPX, RNASE3, IL13, IL4, PLA2G7
43dermatitis10.0IL13, IL5, IL4, CMA1, MS4A2, TSLP
44rheumatoid arthritis10.0HAVCR1, CD14, RNASE3, IL13, IL4R, IL4
45respiratory failure10.0SCGB1A1, EPX, CYSLTR1, RNASE3, IL13, CMA1
46multiple sclerosis10.0SCGB1A1, IL13, IL5, IL9, IL4R, IL4
47pulmonary eosinophilia10.0EPX, RNASE3, IL13, IL5, IL4
48gamma chain deficiency10.0IL13, IL9, IL4R, IL4, TSLP
49food allergy10.0EPX, RNASE3, IL13, IL5, IL4
50inflammatory bowel disease10.0CD14, EPX, IL13, IL4, PLA2G7, SELP

Graphical network of the top 20 diseases related to Atopy:



Diseases related to atopy

Clinical Features for Atopy

Sources:
47OMIM
See all sources

Clinical features from OMIM:

147050

Clinical synopsis from OMIM:

147050

Drugs & Therapeutics for Atopy

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Atopy

Drug clinical trials:

Search ClinicalTrials for Atopy

Search NIH Clinical Center for Atopy

Search CenterWatch for Atopy

Genetic Tests for Atopy

Anatomical Context for Atopy

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Atopy:

33
Skin, Brain, Lung, Whole blood, Thyroid, Breast, Placenta, T cells, B cells, Endothelial, Fetal brain, Temporal lobe, Fetal lung, Fetal thyroid

Animal Models for Atopy or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Atopy

Sources:
51PubMed
See all sources

Articles related to Atopy:

(show top 50)    (show all 782)
idTitleAuthorsYear
1
Obesity and adiposity indicators, asthma, and atopy inA Puerto Rican children. (24290290)
2013
2
Home Renovation, Family History of Atopy, and Respiratory Symptoms and Asthma Among Children Living in China. (24228648)
2013
3
Lower lifetime prevalence of atopy in rheumatoid arthritis. (23708584)
2013
4
Non-pro-vitamin A and pro-vitamin A carotenoids in atopy development. (23343622)
2013
5
Genome-wide methylation profiling of the bronchial mucosa of asthmatics: relationship to atopy. (23521807)
2013
6
Environmental conditions, immunologic phenotypes, atopy, and asthma: new evidence of how the hygiene hypothesis operates in Latin America. (23414599)
2013
7
Usefulness of atopy patch test on a child with milk protein-induced enterocolitis syndrome: a case report. (24067480)
2013
8
Asthma and atopy in children born by caesarean section: effect modification by family history of allergies - a population based cross-sectional study. (23153011)
2012
9
Vitamin D and atopy and asthma phenotypes in children. (22475998)
2012
10
Viral infections and atopy in Brazil. (22405624)
2012
11
Toxocara seropositivity, atopy and wheezing in children living in poor neighbourhoods in urban Latin American. (23133689)
2012
12
Different implications of paternal and maternal atopy for perinatal IgE production and asthma development. (22272211)
2012
13
Mouse allergen, lung function, and atopy in Puerto Rican children. (22815744)
2012
14
Association between obesity and atopy in adults? (21447968)
2011
15
Polymorphisms in GSDMA and GSDMB are associated with asthma susceptibility, atopy and BHR. (21337730)
2011
16
A cross-sectional study assessing the relationship between BMI, asthma, atopy, and eNO among schoolchildren. (21962093)
2011
17
Chronic urticaria is associated with a differential helminth-arthropod-related atopy phenotype. (20883361)
2010
18
Nutritional errors in the first months of life and their association with asthma and atopy in preschool children. (20938590)
2010
19
Correlation between atopy and tuberculin/ Candida skin test reactivity in a bacillus Calmette- Gue'rina89vaccinated cohort. (20560903)
2010
20
Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. (20456316)
2010
21
Prevalence and factors linked to atopy in 10-and 11-year-old children in AlmerA-a, Spain. (20092934)
2010
22
Solanum trilobatum in the management of atopy: Through inhibition of mast cell degranulation and moderation of release of interleukins. (21808531)
2010
23
Elevated cord blood IgE is associated with recurrent wheeze and atopy at 7 yrs in a high risk cohort. (19236604)
2009
24
Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. (19029000)
2009
25
Atopy, home environment and the risk of childhood-onset type 1 diabetes: a population-based case-control study. (18547232)
2008
26
The influence of processing factors and non-atopy-related maternal and neonate characteristics on yield and cytokine responses of cord blood mononuclear cells. (18070154)
2008
27
Prospective study of breast-feeding in relation to wheeze, atopy, and bronchial hyperresponsiveness in the Avon Longitudinal Study of Parents and Children (ALSPAC). (18468669)
2008
28
Early identification of atopy in the prediction of persistent asthma in children. (18805338)
2008
29
Are breastfeeding and diet strategies overrated for the prevention of atopy? (18727464)
2008
30
Urban/rural differences in diet and atopy in South Africa. (18315730)
2008
31
Functional characterization of the atopy-associated gene PHF11. (18405956)
2008
32
Airways are more reactive to histamine than to methacholine in patients with mild airway hyperresponsiveness, regardless of atopy. (17939333)
2007
33
Effect of breastfeeding on lung function in childhood and modulation by maternal asthma and atopy. (17690333)
2007
34
Search for quantitative trait loci of atopy-associated immune responses using allergen-specific IgG1 as an "endophenotype". (17961772)
2007
35
Mycobacterial infection and atopy in childhood: a systematic review. (18001426)
2007
36
The interaction of IL1A and endothelial nitric oxide synthase polymorphisms is associated with the degree of atopy. (16815170)
2006
37
Atopy patch testing in children with asthma and rhinitis symptoms allergic to house dust mite. (16846452)
2006
38
Non classical HLA genes and non-HLA genes in a population of infants at familial risk of atopy. (16788244)
2006
39
Atopy and contact hypersensitivity: a reassessment of the relationship using objective measures. (16095143)
2005
40
Diet as a risk factor for atopy and asthma. (15940119)
2005
41
A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population. (15544595)
2004
42
Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter. (12794150)
2003
43
Smoking and atopy as determinants of sputum eosinophilia and bronchial hyper-responsiveness in adults with normal lung function. (12924523)
2003
44
A birth cohort study of subjects at risk of atopy: twenty-two-year follow-up of wheeze and atopic status. (11790650)
2002
45
Evidence for association and linkage between atopy, airway hyper-responsiveness, and the beta subunit Glu237Gly variant of the high-affinity receptor for immunoglobulin E in the French-Canadian population. (10941841)
2000
46
Epidemiological study of the genetics and environment of asthma, bronchial hyperresponsiveness, and atopy: phenotype issues. (9351592)
1997
47
Genetics of atopy and asthma: promoter-based candidate gene studies for IL-4. (9130485)
1997
48
The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. (7797786)
1995
49
The IgE response and atopy. (1953921)
1991
50
The relation of airways responsiveness and atopy to the development of chronic obstructive lung disease. (3066629)
1988

Genetic Variations for Atopy

Expression for genes affiliated with Atopy

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Atopy

Search GEO for disease gene expression data for Atopy.

Pathways for genes affiliated with Atopy

Sources:
30KEGG, 52QIAGEN, 12EMD Millipore, 38NCBI BioSystems Database, 53R&D Systems, 50PharmGKB
See all sources

Pathways related to Atopy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.9EPX, RNASE3, IL13, IL5, IL9, IL4R
2
Hide members
10.8IL13, IL5, IL4R, IL4, PLA2G7, MS4A2
3
Hide members
10.8PLA2G7, IL4, IL4R, IL9, IL5, IL13
4
Hide members
10.8CD14, IL13, IL5, IL9, IL4R, TSLP
510.8IL13, IL5, IL9, IL4R, IL4, TSLP
610.8IL4, IL4R, IL9, IL5, IL13
7
Hide members
10.8IL4, IL4R, IL9, IL5, IL13
8
Hide members
10.8IL13, IL5, IL9, IL4R, IL4
910.7IL5, IL4R, IL4, SELP
10
Hide members
10.7IL13, IL5, IL4R, IL4
1110.7IL4, IL4R, IL5, CD14
1210.7IL13, IL5, IL9, IL4
1310.7IL13, IL5, IL9, IL4
1410.7IL5, IL4R, IL4
1510.7IL4, IL5, IL13
1610.6IL4, IL4R
17
Hide members
10.6CYSLTR1, LTC4S

Compounds for genes affiliated with Atopy

Sources:
45Novoseek, 29IUPHAR, 24HMDB, 50PharmGKB, 11DrugBank, 60Tocris Bioscience
See all sources

Compounds related to Atopy according to GeneCards/GeneDecks:

(show top 50)    (show all 119)
idCompoundScoreTop Affiliating Genes
1histamine45 29 2413.7IL4, CMA1, SELP, CYSLTR1, IL4R, IL9
2tyrosine4511.7LTC4S, IL5, HAVCR1, IL4, IL13, RNASE3
3allergens4511.6IL5, CD14, EPX, RNASE3, TSLP, MS4A2
4dexamethasone45 50 29 1114.6PLA2G7, SELP, IL4, RNASE3, IL4R, IL5
5leukotriene b445 60 2413.5CYSLTR2, LTC4S, PLA2G7, IL5, IL13, RNASE3
6arachidonic acid45 29 11 2414.4SELP, PLA2G7, IL4R, CYSLTR1, CYSLTR2, EPX
7aspirin45 50 29 2414.4LTC4S, CYSLTR2, SELP, RNASE3, IL13, IL4
8montelukast45 50 29 1114.3LTC4S, CYSLTR2, CYSLTR1, RNASE3, IL13, IL5
9pgd24511.3LTC4S, CYSLTR2, RNASE3, IL13, IL5, CYSLTR1
10lipid4511.3RNASE3, PLA2G7, EPX, CD14, CYSLTR2, LTC4S
11fmlp4511.3IL5, SELP, CD14, EPX, CYSLTR2, IL13
12nitric oxide45 11 2413.3CYSLTR2, RNASE3, IL13, IL9, SCGB1A1, PLA2G7
13heparin45 29 11 2414.3CMA1, IL13, CYSLTR2, CD14, SELP, EPX
14lte44511.3CYSLTR2, EPX, CYSLTR1, LTC4S, RNASE3, IL5
15ltd44511.3CYSLTR2, CYSLTR1, LTC4S, IL13, RNASE3, IL5
16budesonide45 50 1113.3IL4, RNASE3, SELP, EPX, IL13, IL5
17ltc44511.3LTC4S, CYSLTR1, IL13, RNASE3, IL5, EPX
18cyclosporin a45 29 6013.3SELP, IL4R, IL5, IL13, IL4, CD14
19methacholine45 1112.2CD14, RNASE3, IL13, IL5, IL9, IL4
20tarc4511.2IL9, IL13, IL4R, IL4, TSLP, IL5
21theophylline45 29 11 2414.2SELP, IL5, IL13, RNASE3, CYSLTR1, EPX
22pge24511.2PLA2G7, CYSLTR2, EPX, CYSLTR1, LTC4S
23p0024511.2RNASE3, EPX, PLA2G7, SCGB1A1, LTC4S, CD14
24rantes4511.2IL4, CD14, IL4R, IL9, RNASE3
25pranlukast45 29 1113.2CYSLTR1, CYSLTR2, RNASE3, IL5, IL4
26salmeterol45 50 29 1114.2IL4, IL5, IL13, RNASE3, EPX
27salbutamol45 50 29 11 2415.2CYSLTR1, RNASE3, IL13, EPX, IL5
28omalizumab45 1112.1MS4A2, IL4, IL5, IL13
29prednisolone45 29 1113.1IL13, EPX, RNASE3, IL5, CD14
30mk 57145 6012.1IL4, IL5, CYSLTR1, CYSLTR2
31praziquantel45 1112.1IL4, IL5, IL13, RNASE3
32fluticasone propionate45 50 60 1114.1IL4, IL5, IL13, RNASE3
33rolipram45 60 2913.0IL13, IL4, EPX, IL5
34txb24511.0SELP, RNASE3, PLA2G7, CD14
35unicap4511.0RNASE3, IL5, CD14
36methylcellulose4511.0CD14, IL4, IL9, IL5
37il 104511.0IL4R, IL4, IL13, IL5
38ionomycin4511.0IL5, IL4, IL4R, IL9, IL13
39cysteine4511.0CMA1, LTC4S, CD14, EPX, IL13, IL5
40beclomethasone dipropionate4511.0CYSLTR1, RNASE3, IL5
41sodium cromoglycate4510.9IL5, RNASE3, EPX
42gm-csf45 2911.9CD14
43c-d4t4510.9IL5, IL4, IL9
44endotoxin4510.9RNASE3, PLA2G7, SCGB1A1
45formoterol45 29 1112.8IL4, IL13, RNASE3
46pentoxifylline45 1111.8CD14, IL13, IL4, SELP
475-oxoete4510.8CYSLTR1, CYSLTR2, IL5
48nedocromil sodium4510.7RNASE3, IL4, IL5
49cetirizine45 29 11 2413.6EPX, RNASE3, IL5
50zafirlukast45 29 1112.4CYSLTR2, RNASE3, CYSLTR1

GO Terms for genes affiliated with Atopy

Sources:
16Gene Ontology
See all sources

Cellular components related to Atopy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular spaceGO:00561510.9TSLP, SCGB1A1, CD14, IL13, IL5, IL9
2extracellular regionGO:00557610.9SPINK5, PLA2G7, CMA1, IL5, IL13, RNASE3
3external side of plasma membraneGO:00989710.4IL13, IL4, MS4A2, SELP

Biological processes related to Atopy according to GeneCards/GeneDecks:

(show all 9)
idNameGO IDScoreTop Affiliating Genes
1inflammatory responseGO:00695411.1SELP, CD14, CYSLTR1, IL13, IL5, IL9
2immune responseGO:00695511.0CYSLTR2, IL13, IL5, IL9, IL4R, IL4
3positive regulation of B cell proliferationGO:03089010.8IL13, IL5, IL4
4regulation of proton transportGO:01015510.7IL4, IL13
5response to lipopolysaccharideGO:03249610.7SELP, IL13, SCGB1A1
6negative regulation of interleukin-5 productionGO:03271410.7EPX, SCGB1A1
7positive regulation of macrophage activationGO:04303210.6IL4R, IL13
8positive regulation of angiogenesisGO:04576610.6CYSLTR2, CYSLTR1, CMA1
9defense response to protozoanGO:04283210.3IL4, IL4R

Molecular functions related to Atopy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytokine activityGO:00512510.7TSLP, IL4, IL9, IL5, IL13
2lipopolysaccharide bindingGO:00153010.6SELP, CD14
3leukotriene receptor activityGO:00497410.3CYSLTR1, CYSLTR2

Products for genes affiliated with Atopy

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopy

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet