ATOPY
MCID: ATP002
MIFTS: 52

Atopy (ATOPY) malady

Summaries for Atopy

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66Wikipedia, 48OMIM, 34MalaCards
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Wikipedia:66 Atopy (pron. {ay-top-pee}); Greek ?????? - placelessness, out of place, special, unusual, extraordinary)... more...

MalaCards: Atopy is related to asthma and dermatitis. An important gene associated with Atopy is IL4R (interleukin 4 receptor), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The compounds omalizumab and formoterol have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and t cells, and related mouse phenotypes are digestive/alimentary and integument.

Description from OMIM:48 147050

Aliases & Classifications for Atopy

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48OMIM, 46Novoseek, 63UMLS
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Aliases & Descriptions:

atopy 48 46 63


Related Diseases for Atopy

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18GeneCards, 19GeneDecks
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Diseases related to Atopy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 173)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.6IL13, PLA2G7
2dermatitis31.1CMA1, TSLP, MS4A2, IL4, IL13
3atopic dermatitis30.9SPINK5, FCER2, RNASE3, TSLP, IL4, IL13
4rhinitis30.9IL13, IL9, IL4, MS4A2, CMA1, EPX
5allergic rhinitis30.6FCER2, RNASE3, EPX, IL4, IL4R, IL13
6food allergy30.6RNASE3, EPX, IL4, IL13
7otitis media30.4CD14, RNASE3
8keratoconjunctivitis30.3IL13, RNASE3
9urticaria30.3FCER2, RNASE3, LTC4S
10vernal keratoconjunctivitis30.3RNASE3, CMA1, IL4, IL13
11sinusitis30.2CYSLTR1, RNASE3, LTC4S
12bronchiolitis30.1FCER2, RNASE3, IL4R, IL13
13bronchitis30.1IL9, RNASE3
14sarcoidosis30.1CD14, IL13, IL9, SELP, FCER2
15nephrotic syndrome30.1CD14, PLA2G7, IL13, IL4R
16eosinophilia30.0CYSLTR1, FCER2, RNASE3, EPX, CD14, IL13
17malaria30.0FCER2
18rheumatoid arthritis30.0HAVCR1, FCER2, SELP, RNASE3, IL4, IL4R
19chronic rhinitis30.0RNASE3
20myocardial infarction30.0CYSLTR2, SELP, PLA2G7, CD14
21helminthiasis30.0RNASE3, IL13
22mastocytosis30.0IL13, IL9, CMA1
23churg-strauss syndrome30.0CYSLTR1, RNASE3
24netherton syndrome30.0TSLP, SPINK5
25esophagitis30.0IL13
26tetanus29.9IL4, IL9, IL13
27intrinsic asthma29.9IL4, RNASE3, FCER2
28non-hodgkin lymphoma29.9CD14, IL9, IL4R, FCER2
29multiple sclerosis29.9IL4, IL4R, IL9, IL13
30skin disease29.9IL13, IL4, RNASE3, FCER2, SPINK5
31b-cell lymphomas29.9FCER2, IL4R, CD14
32bronchopulmonary dysplasia29.8RNASE3, PLA2G7
33leukemia29.8FCER2, RNASE3, EPX, LTC4S, CD14, IL9
34allergic asthma29.6IL13, IL9, IL4R, IL4, MS4A2, TSLP
35obesity10.4
36cystic fibrosis10.3
37alopecia10.3
38alopecia areata10.2
39allergic bronchopulmonary aspergillosis10.2
40aspergillosis10.2
41pulmonary function10.2
42kimura disease10.1RNASE3
43eosinophilic esophagitis10.1TSLP
44conjunctivitis10.1RNASE3, MS4A2
45common cold10.1RNASE3
46collagenous colitis10.1RNASE3
47onchocerciasis10.1RNASE3, EPX
48autosomal dominant hyper ige syndrome10.1RNASE3, IL4
49proctitis10.1RNASE3, EPX
50eosinophilic pneumonia10.1RNASE3, IL13

Graphical network of the top 20 diseases related to Atopy:



Diseases related to atopy

Symptoms for Atopy

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48OMIM
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Symptoms by clinical synopsis from OMIM:

147050

Clinical features from OMIM:

147050

Drugs & Therapeutics for Atopy

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 63UMLS, 42NDF-RT
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Approved drugs:

Search CenterWatch for Atopy

Drug clinical trials:

Search ClinicalTrials for Atopy

Search NIH Clinical Center for Atopy

Search CenterWatch for Atopy

Genetic Tests for Atopy

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Anatomical Context for Atopy

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34MalaCards
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MalaCards organs/tissues related to Atopy:

34
Testes, Lung, T cells, Skin, Breast, Endothelial, Thyroid, Whole blood, Eye, Placenta, Brain, B cells

Animal Models for Atopy or affiliated genes

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38MGI
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MGI Mouse Phenotypes related to Atopy:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.5IL13, IL4R, IL4, TSLP, FCER2, IL9
2MP:00107719.2TSLP, SELP, IL4, CYSLTR2, SPINK5, IL4R
3MP:00053888.9CYSLTR1, LTC4S, SELP, HAVCR1, TSLP, IL4
4MP:00053768.6SELP, TSLP, IL4, IL4R, IL9, IL13
5MP:00053978.6HAVCR1, SPINK5, FCER2, SELP, EPX, CMA1
6MP:00053878.1CYSLTR1, SPINK5, HAVCR1, FCER2, SELP, EPX

Publications for Atopy

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Sources:
53PubMed
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Articles related to Atopy:

(show top 50)    (show all 773)
idTitleAuthorsYear
1
The immunomodulatory effect of probiotics beyond atopy: an update. (24256057)
2013
2
The role of hydrolysates for atopy prevention - con. (24299445)
2013
3
Soluble CD23 levels are inversely associated with atopy and parasite-specific IgE levels but not with polyclonal IgE levels in people exposed to helminth infection. (23689700)
2013
4
The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa. (23724245)
2013
5
Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status. (23706712)
2013
6
Early incidence of occupational asthma is not accelerated by atopy in the bakery/pastry and hairdressing sectors. (23743318)
2013
7
Atypical croup: association with airway lesions, atopy, and esophagitis. (22588730)
2012
8
Platycodon grandiflorus alleviates DNCB-induced atopy-like dermatitis in NC/Nga mice. (23087507)
2012
9
Asthma and atopy in children born by caesarean section: effect modification by family history of allergies - a population based cross-sectional study. (23153011)
2012
10
Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age. (21396408)
2011
11
Promoter polymorphisms of the CD14 gene are associated with atopy in Pakistani adults. (21905503)
2011
12
X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. (20028375)
2010
13
Relationship of serum cholesterol levels to atopy in the US population. (20015326)
2010
14
House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy. (19997746)
2010
15
Infant atopy and allergic diseases: an introduction to dietary aspects. (19645154)
2009
16
IL15 gene variants are not associated with asthma and atopy. (19133918)
2009
17
Helicobacter pylori and lung function, asthma, atopy and allergic disease--a population-based cross-sectional study in adults. (19109248)
2009
18
Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. (19610259)
2009
19
Correlation between atopy and hypersensitivity reactions during therapy with three different TNF-alpha blocking agents in rheumatoid arthritis. (19473578)
2009
20
Atopy, home environment and the risk of childhood-onset type 1 diabetes: a population-based case-control study. (18547232)
2008
21
Maternal stress and perinatal programming in the expression of atopy. (19838310)
2008
22
Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. (18417506)
2008
23
The association between anxiety sensitivity and atopy in adult asthmatics. (18612807)
2008
24
High birth weight, asthma and atopy at the age of 16 yr. (18208461)
2008
25
Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency. (18450128)
2008
26
Fractional exhaled nitric oxide in patients with atopic asthma: correct definitions of the terms atopy and asthma. (18681096)
2008
27
Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. (17573729)
2007
28
Atopy in early life and effect of a primary prevention program for asthma in a high-risk cohort. (17919706)
2007
29
The interaction of IL1A and endothelial nitric oxide synthase polymorphisms is associated with the degree of atopy. (16815170)
2006
30
Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. (16433854)
2006
31
NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population. (15988535)
2005
32
The environment and risk factors for atopy. (16216168)
2005
33
Increase of cerebrospinal fluid soluble interleukin-2 receptor index in a patient with atopy and syringohydromyelia. (16118894)
2005
34
Effects of dog ownership and genotype on immune development and atopy in infancy. (14767447)
2004
35
Determination of allergen-specific IgE in patients with atopy or allergy symptoms]. (12970591)
2003
36
Low molecular weight PTP-IL-4RA interaction in atopy predisposition. (12144546)
2002
37
Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. (11429321)
2001
38
Association of a promoter polymorphism of the CD14 gene and atopy. (11282774)
2001
39
Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (10940079)
2000
40
Ethnic differences in genetic susceptibility to atopy and asthma in Singapore. (10976388)
2000
41
The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (10733466)
2000
42
An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). (10887320)
2000
43
The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. (10233717)
1999
44
Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families. (10227402)
1999
45
Two common polymorphisms in the coding part of the CD43 gene are not associated with atopy. (9876225)
1998
46
Interleukin-4 and the genetics of atopy. (9392706)
1997
47
Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis. (8769507)
1996
48
The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. (7797786)
1995
49
IL-4: a key cytokine in atopy. (7812882)
1994
50
Atopy in lichen simplex (neurodermatitis circumscripta). (4802403)
1973

Variations for Atopy

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Expression for genes affiliated with Atopy

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atopy

Search GEO for disease gene expression data for Atopy.

Pathways for genes affiliated with Atopy

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Sources:
51PathCards, 55R&D Systems, 39NCBI BioSystems Database, 52PharmGKB, 56Reactome, 61Thomson Reuters, 54QIAGEN, 31KEGG, 13EMD Millipore
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Pathways related to Atopy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL4, IL4R
210.1IL4, IL13
310.1LTC4S, CYSLTR1
4
Show member pathways
10.1CYSLTR2, CYSLTR1
5
Show member pathways
IL-9 Signaling Pathway39
Development Thrombopoietin regulated cell processes61
IL-7 Signaling Pathway39
Immune response IL 9 signaling pathway61
10.0IL9, IL4, IL4R
6
Show member pathways
10.0IL13, IL4R, IL4
710.0IL9, IL13, IL4
810.0IL9, IL4, IL13
9
Show member pathways
Immune response IL 4 signaling pathway61
Signal transduction AKT signaling61
10.0FCER2, IL4, IL4R
109.9IL9, IL13, IL4, IL4R
119.8FCER2, SELP, IL4, IL4R
129.8FCER2, IL4, IL4R, CD14
13
Show member pathways
9.8IL4, IL4R, CD14, FCER2
14
Show member pathways
9.8IL13, IL4, PLA2G7, IL4R, IL9
15
Show member pathways
Type III interferon signaling39
9.7TSLP, IL4, IL4R, IL9, IL13
16
Show member pathways
9.4IL4R, RNASE3, EPX, MS4A2, IL4, IL9
17
Show member pathways
9.2TSLP, IL4, FCER2, IL4R, IL13, CD14

Compounds for genes affiliated with Atopy

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46Novoseek, 12DrugBank, 30IUPHAR, 62Tocris Bioscience, 52PharmGKB, 25HMDB, 3BitterDB
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Compounds related to Atopy according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1omalizumab46 1211.4IL13, IL4, MS4A2
2formoterol46 30 1212.3RNASE3, IL4, IL13
3lte43010.2CYSLTR2, CYSLTR1
4praziquantel46 1211.2RNASE3, IL4, IL13
5zafirlukast46 30 1212.2CYSLTR1, CYSLTR2, RNASE3
6nedocromil sodium4610.2FCER2, RNASE3, IL4
7bayu97733010.2CYSLTR1, CYSLTR2
8mk 57162 4611.2CYSLTR1, CYSLTR2, IL4
9pentoxifylline46 1211.2SELP, IL4, IL13, CD14
10salmeterol46 52 30 1213.2IL13, IL4, EPX, RNASE3
11pranlukast46 30 1212.1CYSLTR1, CYSLTR2, RNASE3, IL4
12tarc4610.1IL13, IL9, IL4R, IL4, TSLP
13iralukast3010.1CYSLTR1, CYSLTR2
14[3h]ltd43010.1CYSLTR1, CYSLTR2
15budesonide46 52 1212.1SELP, RNASE3, EPX, IL4, IL13
16ltd44610.1CYSLTR1, CYSLTR2, RNASE3, IL13, LTC4S
17p0034610.0CD14, IL13, IL4R, RNASE3
18lte44610.0CYSLTR1, CYSLTR2, RNASE3, EPX, LTC4S
19txb24610.0CD14, PLA2G7, RNASE3, SELP, FCER2
20ltc44610.0CYSLTR1, RNASE3, EPX, IL13, LTC4S
21ionomycin4610.0FCER2, IL4, IL4R, IL9, IL13
22methacholine46 52 1212.0RNASE3, IL4, IL9, IL13, CD14
23p0024610.0RNASE3, EPX, PLA2G7, CD14, LTC4S
24n-methyl ltc43010.0CYSLTR1, CYSLTR2
25theophylline46 30 25 1213.0CYSLTR1, SELP, RNASE3, EPX, IL13
26prednisolone46 30 1212.0RNASE3, EPX, IL13, CD14
27salbutamol46 52 30 25 1214.0CYSLTR1, FCER2, RNASE3, EPX, IL13
28hydrocortisone46 3 62 1212.9FCER2, IL4, IL13, CD14
29pgd2469.9CYSLTR1, CYSLTR2, RNASE3, EPX, IL13, LTC4S
30montelukast46 52 30 1212.9CYSLTR1, CYSLTR2, RNASE3, IL4, IL13, LTC4S
31cyclosporin a46 30 6211.9SELP, RNASE3, IL4, IL4R, IL13, CD14
32baycyslt2309.8CYSLTR1, CYSLTR2
33rantes469.8SELP, RNASE3, IL4, IL4R, IL9, IL13
34cycloheximide469.7FCER2, IL4, IL4R, IL13, PLA2G7, CD14
35lactate469.7FCER2, SELP, RNASE3, EPX, IL13, CD14
36heparin46 30 25 1212.7CYSLTR2, SELP, RNASE3, EPX, CMA1, IL13
37fmlp469.7CYSLTR2, FCER2, SELP, RNASE3, EPX, IL13
38arachidonic acid46 30 25 1212.7CYSLTR1, CYSLTR2, SELP, EPX, IL4R, IL13
39aspirin46 52 30 2512.6CYSLTR1, CYSLTR2, SELP, RNASE3, IL4, IL13
40nitric oxide46 25 1211.6CYSLTR2, FCER2, SELP, RNASE3, EPX, IL9
41cysteine469.5FCER2, SELP, EPX, CMA1, IL4, IL13
42serine469.5SPINK5, FCER2, EPX, CMA1, IL4R, IL9
43leukotriene b446 62 2511.4CYSLTR1, CYSLTR2, FCER2, SELP, RNASE3, EPX
44lipid469.4CYSLTR1, CYSLTR2, RNASE3, EPX, IL9, PLA2G7
45allergens469.1CMA1, TSLP, MS4A2, IL4, IL4R, IL9
46calcium46 52 25 1212.1CYSLTR1, CYSLTR2, FCER2, RNASE3, EPX, CMA1
47dexamethasone46 52 30 1212.1CYSLTR1, FCER2, SELP, RNASE3, EPX, IL4
48pge2469.1CYSLTR1, CYSLTR2, FCER2, SELP, RNASE3, EPX
49tyrosine468.8SELP, FCER2, CYSLTR2, CYSLTR1, HAVCR1, RNASE3
50histamine46 30 2510.8RNASE3, EPX, CMA1, IL4, IL4R, IL9

GO Terms for genes affiliated with Atopy

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17Gene Ontology
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Cellular components related to Atopy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6IL13, IL4, MS4A2, SELP, FCER2
2extracellular regionGO:0055769.6CD14, PLA2G7, IL13, CMA1, RNASE3, SPINK5
3extracellular spaceGO:0056159.1SELP, TSLP, IL4, IL4R, IL9, IL13

Biological processes related to Atopy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:01015510.2IL4, IL13
2defense response to protozoanGO:04283210.2IL4R, IL4
3response to ethanolGO:04547110.0CD14, IL13, IL4
4positive regulation of macrophage activationGO:0430329.9IL13, IL4R
5positive regulation of angiogenesisGO:0457669.9CYSLTR1, CYSLTR2, CMA1
6immune responseGO:0069559.7CYSLTR2, MS4A2, IL4, IL4R, IL9, IL13
7inflammatory responseGO:0069549.7CD14, IL13, IL9, MS4A2, SELP, CYSLTR1

Molecular functions related to Atopy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2CD14, SELP
2leukotriene receptor activityGO:00497410.0CYSLTR1, CYSLTR2
3IgE bindingGO:0198639.8MS4A2, FCER2
4cytokine activityGO:0051259.8IL13, IL9, IL4, TSLP

Products for genes affiliated with Atopy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atopy

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet