ATOPY
MCID: ATP002
MIFTS: 53

Atopy (ATOPY) malady

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Summaries for Atopy

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Wikipedia:65 Atopy /? more...

MalaCards based summary: Atopy is related to asthma and dermatitis, and has symptoms including An important gene associated with Atopy is IL4R (interleukin 4 receptor), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The compounds omalizumab and formoterol have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and t cells, and related mouse phenotypes are digestive/alimentary and integument.

Description from OMIM:46 147050

Aliases & Classifications for Atopy

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Sources:
46OMIM, 44Novoseek, 62UMLS
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Atopy, Aliases & Descriptions:

Name: Atopy 46 44 62


Related Diseases for Atopy

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Diseases related to Atopy via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 171)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.9PLA2G7, IL13
2dermatitis31.5IL4, MS4A2, TSLP, CMA1, IL13
3atopic dermatitis31.2RNASE3, IL13, IL4, FCER2, TSLP, SPINK5
4food allergy31.0RNASE3, IL13, EPX, IL4
5keratoconjunctivitis31.0IL13, RNASE3
6rhinitis30.9EPX, RNASE3, FCER2, CYSLTR1, CMA1, MS4A2
7allergic rhinitis30.9IL4, FCER2, IL4R, EPX, RNASE3, IL13
8sinusitis30.8CYSLTR1, LTC4S, RNASE3
9urticaria30.8FCER2, RNASE3, LTC4S
10otitis media30.8RNASE3, CD14
11vernal keratoconjunctivitis30.7IL13, IL4, CMA1, RNASE3
12malaria30.7FCER2
13chronic rhinitis30.7RNASE3
14bronchiolitis30.6RNASE3, FCER2, IL4R, IL13
15helminthiasis30.6IL13, RNASE3
16bronchitis30.5IL9, RNASE3
17mastocytosis30.5CMA1, IL9, IL13
18churg-strauss syndrome30.5CYSLTR1, RNASE3
19netherton syndrome30.5SPINK5, TSLP
20esophagitis30.5IL13
21tetanus30.4IL13, IL4, IL9
22intrinsic asthma30.4IL4, RNASE3, FCER2
23non-hodgkin lymphoma30.4CD14, IL9, IL4R, FCER2
24multiple sclerosis30.3IL13, IL4, IL4R, IL9
25sarcoidosis30.2CD14, IL13, FCER2, IL9, SELP
26skin disease30.2IL4, RNASE3, FCER2, SPINK5, IL13
27nephrotic syndrome30.2PLA2G7, IL13, CD14, IL4R
28b-cell lymphomas30.2CD14, FCER2, IL4R
29eosinophilia30.1CYSLTR1, FCER2, RNASE3, EPX, IL4, IL9
30bronchopulmonary dysplasia30.0PLA2G7, RNASE3
31rheumatoid arthritis29.9IL4R, SELP, FCER2, HAVCR1, IL13, CD14
32leukemia29.9IL9, CD14, EPX, IL4, IL4R, RNASE3
33myocardial infarction29.9CD14, CYSLTR2, PLA2G7, SELP
34allergic asthma28.9RNASE3, EPX, CMA1, TSLP, MS4A2, IL4
35kimura disease10.5RNASE3
36conjunctivitis10.5MS4A2, RNASE3
37eosinophilic esophagitis10.5TSLP
38common cold10.5RNASE3
39collagenous colitis10.5RNASE3
40onchocerciasis10.5EPX, RNASE3
41autosomal dominant hyper ige syndrome10.5IL4, RNASE3
42eosinophilic pneumonia10.5RNASE3, IL13
43proctitis10.5RNASE3, EPX
44lipoid nephrosis10.4FCER2, IL4R, IL13
45kaposi's sarcoma10.4CD14, CYSLTR2, IL4R
46schistosomiasis10.4IL13, RNASE3, IL4
47allergic conjunctivitis10.4IL4, RNASE3, IL13
48extrinsic allergic alveolitis10.4CD14, FCER2
49uveitis10.4CD14, IL4, IL9
50cutaneous leishmaniasis10.4IL4, IL13, FCER2

Graphical network of the top 20 diseases related to Atopy:



Diseases related to atopy

Symptoms for Atopy

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Symptoms by clinical synopsis from OMIM:

147050

Clinical features from OMIM:

147050

HPO human phenotypes related to Atopy:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 eczema HP:0000964
3 abnormality of metabolism/homeostasis HP:0001939
4 asthma HP:0002099

Drugs & Therapeutics for Atopy

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Drug clinical trials:

Search ClinicalTrials for Atopy

Search NIH Clinical Center for Atopy

Genetic Tests for Atopy

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Anatomical Context for Atopy

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MalaCards organs/tissues related to Atopy:

32
Testes, Lung, T cells, Skin, Breast, Endothelial, Thyroid, Neutrophil, Eye, Whole blood, Brain, Placenta, B cells

Animal Models for Atopy or affiliated genes

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MGI Mouse Phenotypes related to Atopy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.5IL13, IL4R, IL4, TSLP, FCER2, IL9
2MP:00107719.2TSLP, SELP, IL4, CYSLTR2, SPINK5, IL4R
3MP:00053888.9CYSLTR1, LTC4S, SELP, HAVCR1, TSLP, IL4
4MP:00053768.6SELP, TSLP, IL4, IL4R, IL9, IL13
5MP:00053978.6HAVCR1, SPINK5, FCER2, SELP, EPX, CMA1
6MP:00053878.1CYSLTR1, SPINK5, HAVCR1, FCER2, SELP, EPX

Publications for Atopy

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Articles related to Atopy:

(show top 50)    (show all 798)
idTitleAuthorsYear
1
Atopy and cause-specific mortality. (25220375)
2014
2
The immunomodulatory effect of probiotics beyond atopy: an update. (24256057)
2013
3
The role of hydrolysates for atopy prevention - con. (24299445)
2013
4
Soluble CD23 levels are inversely associated with atopy and parasite-specific IgE levels but not with polyclonal IgE levels in people exposed to helminth infection. (23689700)
2013
5
The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa. (23724245)
2013
6
Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status. (23706712)
2013
7
Atypical croup: association with airway lesions, atopy, and esophagitis. (22588730)
2012
8
Platycodon grandiflorus alleviates DNCB-induced atopy-like dermatitis in NC/Nga mice. (23087507)
2012
9
Asthma and atopy in children born by caesarean section: effect modification by family history of allergies - a population based cross-sectional study. (23153011)
2012
10
Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age. (21396408)
2011
11
Promoter polymorphisms of the CD14 gene are associated with atopy in Pakistani adults. (21905503)
2011
12
X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. (20028375)
2010
13
Relationship of serum cholesterol levels to atopy in the US population. (20015326)
2010
14
House dust mite-related allergic diseases: role of skin prick test, atopy patch test, and RAST in the diagnosis of different manifestations of allergy. (19997746)
2010
15
Infant atopy and allergic diseases: an introduction to dietary aspects. (19645154)
2009
16
IL15 gene variants are not associated with asthma and atopy. (19133918)
2009
17
Helicobacter pylori and lung function, asthma, atopy and allergic disease--a population-based cross-sectional study in adults. (19109248)
2009
18
Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. (19610259)
2009
19
Correlation between atopy and hypersensitivity reactions during therapy with three different TNF-alpha blocking agents in rheumatoid arthritis. (19473578)
2009
20
Atopy, home environment and the risk of childhood-onset type 1 diabetes: a population-based case-control study. (18547232)
2008
21
Maternal stress and perinatal programming in the expression of atopy. (19838310)
2008
22
Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. (18417506)
2008
23
The association between anxiety sensitivity and atopy in adult asthmatics. (18612807)
2008
24
High birth weight, asthma and atopy at the age of 16 yr. (18208461)
2008
25
Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency. (18450128)
2008
26
Fractional exhaled nitric oxide in patients with atopic asthma: correct definitions of the terms atopy and asthma. (18681096)
2008
27
Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. (17573729)
2007
28
Atopy in early life and effect of a primary prevention program for asthma in a high-risk cohort. (17919706)
2007
29
The interaction of IL1A and endothelial nitric oxide synthase polymorphisms is associated with the degree of atopy. (16815170)
2006
30
Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. (16433854)
2006
31
NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population. (15988535)
2005
32
The environment and risk factors for atopy. (16216168)
2005
33
Increase of cerebrospinal fluid soluble interleukin-2 receptor index in a patient with atopy and syringohydromyelia. (16118894)
2005
34
Effects of dog ownership and genotype on immune development and atopy in infancy. (14767447)
2004
35
Determination of allergen-specific IgE in patients with atopy or allergy symptoms]. (12970591)
2003
36
Low molecular weight PTP-IL-4RA interaction in atopy predisposition. (12144546)
2002
37
Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. (11429321)
2001
38
Association of a promoter polymorphism of the CD14 gene and atopy. (11282774)
2001
39
Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (10940079)
2000
40
Ethnic differences in genetic susceptibility to atopy and asthma in Singapore. (10976388)
2000
41
The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (10733466)
2000
42
An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). (10887320)
2000
43
The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. (10233717)
1999
44
Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families. (10227402)
1999
45
Two common polymorphisms in the coding part of the CD43 gene are not associated with atopy. (9876225)
1998
46
Interleukin-4 and the genetics of atopy. (9392706)
1997
47
Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis. (8769507)
1996
48
The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. (7797786)
1995
49
IL-4: a key cytokine in atopy. (7812882)
1994
50
Atopy in lichen simplex (neurodermatitis circumscripta). (4802403)
1973

Variations for Atopy

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Expression for genes affiliated with Atopy

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Expression patterns in normal tissues for genes affiliated with Atopy

Search GEO for disease gene expression data for Atopy.

Pathways for genes affiliated with Atopy

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Pathways related to Atopy according to GeneCards/GeneDecks:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL4, IL4R
210.1IL4, IL13
310.1LTC4S, CYSLTR1
4
Show member pathways
10.1CYSLTR2, CYSLTR1
5
Show member pathways
IL-9 Signaling Pathway37
Development Thrombopoietin regulated cell processes60
IL-7 Signaling Pathway37
Immune response IL 9 signaling pathway60
10.0IL9, IL4, IL4R
6
Show member pathways
10.0IL13, IL4R, IL4
710.0IL9, IL13, IL4
810.0IL9, IL4, IL13
9
Show member pathways
Immune response IL 4 signaling pathway60
Signal transduction AKT signaling60
10.0FCER2, IL4, IL4R
109.9IL9, IL13, IL4, IL4R
119.8FCER2, SELP, IL4, IL4R
129.8FCER2, IL4, IL4R, CD14
13
Show member pathways
9.8IL4, IL4R, CD14, FCER2
14
Show member pathways
9.8IL13, IL4, PLA2G7, IL4R, IL9
15
Show member pathways
Type III interferon signaling37
9.7TSLP, IL4, IL4R, IL9, IL13
16
Show member pathways
9.4IL4R, RNASE3, EPX, MS4A2, IL4, IL9
17
Show member pathways
9.2TSLP, IL4, FCER2, IL4R, IL13, CD14

Compounds for genes affiliated with Atopy

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Compounds related to Atopy according to GeneCards/GeneDecks:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1omalizumab44 1111.4IL4, MS4A2, IL13
2formoterol44 28 1112.3IL4, IL13, RNASE3
3[3h]ici-1986152810.2CYSLTR2, CYSLTR1
4zafirlukast44 28 1112.2CYSLTR2, CYSLTR1, RNASE3
5nedocromil sodium4410.2RNASE3, FCER2, IL4
6praziquantel44 1111.2RNASE3, IL4, IL13
7mk 57161 4411.2CYSLTR1, CYSLTR2, IL4
8lte42810.2CYSLTR1, CYSLTR2
9pentoxifylline44 1111.2SELP, IL13, IL4, CD14
10salmeterol44 50 28 1113.2RNASE3, EPX, IL13, IL4
11pranlukast44 28 1112.1CYSLTR1, CYSLTR2, RNASE3, IL4
12tarc4410.1IL4, IL13, TSLP, IL9, IL4R
13iralukast2810.1CYSLTR1, CYSLTR2
14[3h]ltd42810.1CYSLTR1, CYSLTR2
15budesonide44 50 1112.1SELP, RNASE3, EPX, IL13, IL4
16ltd44410.1CYSLTR1, CYSLTR2, IL13, LTC4S, RNASE3
17p0034410.0RNASE3, IL4R, IL13, CD14
18lte44410.0RNASE3, EPX, CYSLTR1, LTC4S, CYSLTR2
19txb24410.0CD14, PLA2G7, RNASE3, SELP, FCER2
20ltc44410.0CYSLTR1, LTC4S, RNASE3, EPX, IL13
21ionomycin4410.0IL4, IL4R, IL9, IL13, FCER2
22methacholine44 50 1112.0IL13, RNASE3, IL9, CD14, IL4
23p0024410.0CD14, LTC4S, RNASE3, EPX, PLA2G7
24n-methyl ltc42810.0CYSLTR1, CYSLTR2
25theophylline44 28 24 1113.0IL13, EPX, SELP, CYSLTR1, RNASE3
26prednisolone44 28 1112.0IL13, EPX, RNASE3, CD14
27salbutamol44 50 28 24 1114.0CYSLTR1, FCER2, IL13, EPX, RNASE3
28hydrocortisone44 2 61 1112.9CD14, IL4, FCER2, IL13
29pgd2449.9LTC4S, IL13, EPX, RNASE3, CYSLTR2, CYSLTR1
30montelukast44 50 28 1112.9CYSLTR1, CYSLTR2, IL4, IL13, LTC4S, RNASE3
31cyclosporin a44 28 6111.9CD14, SELP, RNASE3, IL13, IL4R, IL4
32baycyslt2289.8CYSLTR1, CYSLTR2
33rantes449.8CD14, SELP, RNASE3, IL4, IL4R, IL9
34cycloheximide449.7CD14, PLA2G7, IL13, IL4R, IL4, FCER2
35lactate449.7IL13, CD14, EPX, RNASE3, SELP, FCER2
36heparin44 28 24 1112.7CD14, EPX, CMA1, RNASE3, SELP, CYSLTR2
37fmlp449.7SELP, IL13, CYSLTR2, FCER2, RNASE3, EPX
38arachidonic acid44 28 24 1112.7SELP, LTC4S, CYSLTR1, CYSLTR2, EPX, IL4R
39aspirin44 50 28 2412.6SELP, RNASE3, IL4, PLA2G7, CYSLTR2, LTC4S
40nitric oxide44 24 1111.6IL9, FCER2, CYSLTR2, SELP, IL13, RNASE3
41cysteine449.5SELP, IL4, IL13, CD14, LTC4S, CMA1
42serine449.5SPINK5, CMA1, EPX, FCER2, IL4R, IL13
43leukotriene b444 61 2411.4PLA2G7, IL13, EPX, RNASE3, SELP, FCER2
44lipid449.4RNASE3, IL9, CYSLTR2, EPX, CYSLTR1, LTC4S
45allergens449.1IL4R, IL9, IL4, CD14, EPX, RNASE3
46calcium44 50 24 1112.1EPX, FCER2, LTC4S, CD14, CYSLTR2, CYSLTR1
47dexamethasone44 50 28 1112.1EPX, IL4, RNASE3, FCER2, CYSLTR1, SELP
48pge2449.1LTC4S, CD14, PLA2G7, IL13, IL4, EPX
49tyrosine448.8EPX, TSLP, IL4, IL4R, SELP, IL13
50histamine44 28 2410.8SELP, RNASE3, EPX, CMA1, IL4, FCER2

GO Terms for genes affiliated with Atopy

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Cellular components related to Atopy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.6FCER2, SELP, MS4A2, IL4, IL13
2extracellular regionGO:0055769.6SPINK5, RNASE3, CMA1, IL13, PLA2G7, CD14
3extracellular spaceGO:0056159.1SELP, TSLP, IL4, IL4R, IL9, IL13

Biological processes related to Atopy according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:01015510.2IL4, IL13
2defense response to protozoanGO:04283210.2IL4R, IL4
3response to ethanolGO:04547110.0CD14, IL13, IL4
4positive regulation of macrophage activationGO:0430329.9IL13, IL4R
5positive regulation of angiogenesisGO:0457669.9CYSLTR1, CYSLTR2, CMA1
6immune responseGO:0069559.7CYSLTR2, MS4A2, IL4, IL4R, IL9, IL13
7inflammatory responseGO:0069549.7CD14, IL13, IL9, MS4A2, SELP, CYSLTR1

Molecular functions related to Atopy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:00153010.2CD14, SELP
2leukotriene receptor activityGO:00497410.0CYSLTR1, CYSLTR2
3IgE bindingGO:0198639.8MS4A2, FCER2
4cytokine activityGO:0051259.8IL13, IL9, IL4, TSLP

Products for genes affiliated with Atopy

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  • Antibodies
  • Proteins
  • Lysates

Sources for Atopy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet