Atopy malady

Wikipedia: Atopy (pron.: /ˈætəpi/; Greek ἀτοπία - placelessness, out of place, special, unusual) or...⁴⁴ more...

MalaCards: Atopy is related to asthma and atopic dermatitis. An important gene associated with Atopy is MICU1 (mitochondrial calcium uptake 1), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and NFAT Signaling and Lymphocyte Interactions. The compounds sp 600125 and cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lung and breast, and related mouse phenotypes are hematopoietic system and respiratory system.

OMIM: 147050

atopy 7 33 32 43

Diseases related to atopy by text searches and GeneDecks gene sharing:

(show top 50)    (show all 900)

id	Related Disease	Score	Top Affiliating Genes
1	asthma	37.3	SCGB1A1, IL12B, IL13, CCL11, TNF, PLA2G7
2	atopic dermatitis	33.2	KITLG, SELP, NAT2, CMA1, LALBA, MS4A2
3	eczema	32.1	CMA1, LALBA, MS4A2, MPO, CD79A, CD14
4	allergic rhinitis	30.6	IL13, IL4, IL5, IGES, IGHE, TBXA2R
5	food allergy	29.5	FOXP3, IL13, IL4, IL5, CCL11, IGES
6	contact dermatitis	28.8	FLG, IL1A, IL5, IGHE, CXCR3
7	b-cell lymphomas	28.8	BCL6, CIITA, MS4A1, JAK2, CD14, GSTP1
8	allergic bronchopulmonary aspergillosis	28.7	CFTR, IL4, IL5, MBL2, IGES, IGHE
9	bronchitis	28.5	CFTR, MPO, IL5, IL8, IL9, CCL11
10	immunodeficiency	28.4	CIITA, CD28, CD79A, FOXP3, FLG, MIF
11	leprosy	28.3	VDR, IL10, HLA-DQA1, HLA-DRB1, LTA, TLR2
12	dermatitis	28.2	RELA, KITLG, SELP, NAT1, NAT2, VEGFA
13	rheumatoid arthritis	28.2	CHI3L1, IL1RN, MBL2, HLA-DRB1, LTA
14	candidiasis	28.1	MPO, CD79A, MIF, IL10, IL13, IL18
15	hypergammaglobulinemia	28.0	CD79A, IL10, IL2RA, IL5, IL6, IGHE
16	malaria	27.4	IRF1, IL10, IL1A, IL4, IL4R, IFNG
17	epidermolysis bullosa	27.3	CD79A, FLG, ARG1, IL2RA, IL31, IL8
18	skin disease	27.0	VDR, CIITA, CD79A, CDSN, IRF2, FLG
19	tuberculosis	26.4	VDR, IL10, IL12B, IL1B, IL1RN, IL4
20	aspergillosis	26.2	CFTR, CD79A, IL10, IL15, IL1A, IL1B
21	arthritis	26.1	IL1A, IL1B, IL6, IL8, TNF
22	eosinophilia	25.1	MS4A2, MPO, JAK2, CD79A, CD14, FOXP3
23	tetanus	25.0	VEGFA, CIITA, MPO, CD28, CD79A, IL10
24	rhinitis	24.7	RELA, KITLG, VEGFA, CMA1, KDR, SCGB1A1
25	vaginitis	24.3	CD79A, CD14, ARG1, GSTP1, IL10, IL13
26	familial mediterranean fever	24.3	SELP, VEGFA, CD14, FCGR1A, IL10, IL18
27	alopecia areata	24.1	VDR, CIITA, CD79A, FLG, MIF, FCGR1A
28	otitis media	24.0	BCL6, MPO, CD79A, CD14, MIF, FGFR1
29	alopecia	23.7	KITLG, VDR, CIITA, CD79A, FLG, MIF
30	nephrotic syndrome	23.7	RELA, KITLG, SELP, VEGFA, KDR, CFI
31	bronchial asthma	23.1	KITLG, SELP, NAT2, VEGFA, CMA1, SCGB1A1
32	bronchiolitis	23.0	KITLG, VDR, SCGB1A1, MS4A2, MPO, JAK1
33	sinusitis	23.0	RELA, SELP, VEGFA, MTHFR, CFTR, MPO
34	pertussis	22.4	RELA, CHRM3, CFTR, CD79A, CD14, IRAK1
35	cystic fibrosis	20.9	SELP, NAT1, NAT2, VEGFA, VDR, SCGB1A1
36	fibrosis	18.3	RELA, KITLG, SELP, NAT1, NAT2, VEGFA
37	diabetes mellitus	17.8	SELP, NAT1, NAT2, VEGFA, VDR, CIITA
38	obesity	16.9	RELA, SELP, VEGFA, VDR, CIITA, CHI3L1
39	eosinophilic esophagitis	14.7	FLG, IL10, IL13, IL5, IL5RA, CCL26
40	kimura disease	14.6	IL13, IL4, IL5, CCL11, CCR3, IGES
41	urinary schistosomiasis	14.6	IL10, IL13, IL4, IL5, IGHE, IFNG
42	eosinophilic gastroenteritis	14.5	IL5, CCL11, IGES, IGHE, RNASE3, PRG2
43	allergic conjunctivitis	14.4	IL13, IL4, IL5, CCL11, IGHE, RNASE3
44	eosinophilic pneumonia	14.4	IL13, IL3, IL5, CCL22, CCL11, CCL17
45	pthirus pubis infestation	14.4	MIF, FCER2, IL5, CCL11, IGHE, EPX
46	acute interstitial pneumonia	14.4	SCGB1A1, IL13, IL13RA1, IL13RA2, IL4R, NOD2
47	intrinsic asthma	14.4	FCER2, IL3, IL4, IL5, CCL5, IGES
48	bullous pemphigoid	14.4	CIITA, CD79A, FLG, FCER2, IL13, IL5
49	cutaneous leishmaniasis	14.4	FCER2, IL10, IL13, IL4, IL5, IFNG
50	paragonimiasis	14.4	IL5, CCL17, IGHE, RNASE3, RNASE2, CXCR3

Clinical features from OMIM: 147050

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to atopy:

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MGI Mouse Phenotypes related to atopy:

²⁵ (show all 24)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	10.7	JAK1, CD28, ITK, FOXP3, IRAK3, IRF1
2	respiratory system phenotype	MP:0005388	10.7	SELP, BCL6, SCGB1A1, CHRM3, CFTR, CD14
3	integument phenotype	MP:0010771	10.5	RELA, KITLG, SELP, LALBA, CDSN, FOXP3
4	renal/urinary system phenotype	MP:0005367	10.1	SELP, SCGB1A1, CHRM3, CFI, IRS2, FGFR1
5	nervous system phenotype	MP:0003631	8.7	RELA, KITLG, SELP, MTHFR, CD28, IRS2
6	other phenotype	MP:0005395	8.6	KDR, JAK2, IRF2, IL13, IL2, CCR2
7	no phenotypic analysis	MP:0003012	8.3	VEGFA, MTHFR, SART1, CD79A, FOXP3, FGFR1
8	liver/biliary system phenotype	MP:0005370	8.2	VEGFA, BCL6, CHRM3, CFTR, IL12RB2, IL2
9	digestive/alimentary phenotype	MP:0005381	8.0	KITLG, VEGFA, VDR, CHRM3, CFTR, FOXP3
10	normal phenotype	MP:0002873	7.9	RELA, NAT1, VEGFA, KDR, SCGB1A1, CIITA
11	immune system phenotype	MP:0005387	7.8	SELP, VDR, CMA1, KDR, CIITA, CFP
12	growth/size phenotype	MP:0005378	7.6	RELA, KITLG, SELP, VDR, BCL6, SCGB1A1
13	skeleton phenotype	MP:0005390	7.1	RELA, KITLG, VEGFA, VDR, KDR, MTHFR
14	adipose tissue phenotype	MP:0005375	6.9	CHRM3, CD14, IRS2, FGFR2, IL18, IL6
15	tumorigenesis	MP:0002006	6.2	KITLG, SCGB1A1, JAK2, CDSN, IRF1, MIF
16	mortality/aging	MP:0010768	5.9	RELA, KITLG, SELP, VEGFA, VDR, KDR
17	muscle phenotype	MP:0005369	5.1	RELA, VEGFA, KDR, BCL6, CHRM3, MPO
18	vision/eye phenotype	MP:0005391	4.9	RELA, KITLG, SELP, NAT1, VEGFA, KDR
19	cardiovascular system phenotype	MP:0005385	3.7	RELA, KITLG, SELP, VEGFA, VDR, KDR
20	cellular phenotype	MP:0005384	3.3	RELA, KITLG, SELP, VEGFA, VDR, KDR
21	endocrine/exocrine gland phenotype	MP:0005379	INF	, CHRM3, LALBA, CDSN, FGFR1, FGFR2
22	behavior/neurological phenotype	MP:0005386	INF	SELP, VEGFA, VDR, KDR, , CHRM3
23	homeostasis/metabolism phenotype	MP:0005376	INF	RELA, KITLG, SELP, NAT1, NAT2, VEGFA
24	reproductive system phenotype	MP:0005389	INF	NAT1, VEGFA, VDR, BCL6, , LALBA

Articles related to atopy:

(show top 50)    (show all 330)

id	Title	Authors	Year	Affiliating Genes
1	Association of STR polymorphisms in CMA1 and IL-4 wit h asthma and atopy: the SAPALDIA cohort. (20736038)	Hersberger M.... Probst-Hensch N.	2010	TNF, CMA1, IL4
2	Positionally cloned genes and age-specific effects in asthma and atopy: an international population-based cohort study (ECRHS). (19996348)	Castro-Giner F.... Kogevinas M.	2010	ADAM33, SPINK5, DPP10
3	Properdin in childhood and its association with wheez ing and atopy. (20337960)	Staley K.G.... Stover C.	2010	CFP
4	Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eota xin 3/CCL26 expression in lesional and non-lesional skin of patients with atopi c dermatitis. (20236835)	Owczarek W.... Kasztalewicz B.	2010	CCL11, CCL26, CCL24
5	Association of the cysteinyl leukotriene receptor 1 g ene with atopy in the British 1958 birth cohort. (19733299)	Duroudier N.P.... Hall I.P.	2009	CYSLTR1
6	Roles of arginase variants, atopy, and ozone in childhood asthma. (19281908)	Salam M.T.... Gilliland F.D.	2009	ARG1, ARG2
7	PTGDR is not a major candidate gene for asthma and atopy in Chinese children. (19220773)	Leung T.F.... Chan J.C.	2009	PTGDR
8	Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk. (19220214)	Kormann M.S.... Kabesch M.	2009	TLR2
9	Association between CD14 polymorphisms and serum soluble CD14 levels: effect of atopy and endotoxin inhalation. (17949800)	LeVan T.D.... Martinez F.D.	2008	CD14
10	Association of toxic and essential metals with atopy markers and ventilatory lung function in women and men. (18045657)	Pizent A.... Kanceljak-Macan B.	2008	SOD1
11	Lack of association between genetic variation in G-protein-coupled receptor for asthma susceptibility and childhood asthma and atopy. (18340359)	Wu H.... London S.J.	2008	NPSR1
12	Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. (17573729)	Chan I.H.... Lam C.W.	2007	PTGS2
13	STAT1 gene variations, IgE regulation and atopy. (17983380)	Pinto L.A.... Kabesch M.	2007	STAT1, IGHE
14	Quantification of atopy and the probability of rhinitis in preschool children: a population-based birth cohort study. (17822449)	Marinho S.... Custovic A.	2007	IGHE
15	Polymorphisms in eosinophil pathway genes, asthma and atopy. (17362254)	Kabesch M.... Nickel R.	2007	IL3, CSF2RB, CSF2
16	Genetic association studies of interleukin-13 receptor alpha1 subunit gene polymorphisms in asthma and atopy. (17392323)	Konstantinidis A.K.... Holloway J.W.	2007	IL4R, IL13RA1, IL13RA2
17	A functional G300S variant of the cysteinyl leukotriene 1 receptor is associated with atopy in a Tristan da Cunha isolate. (17558309)	Thompson M.D.... Siminovitch K.A.	2007	CYSLTR1, CYSLTR2
18	Genetic impact of functional single nucleotide polymorphisms in the 3'-UTR region of the chemoattractant receptor expressed on Th2 cells (CRTH2) gene on asthma and atopy in a Japanese population. (17016057)	Maeda Y.... Nishimura M.	2007	PTGDR2
19	Asthma and atopy are associated with DEFB1 polymorphisms in Chinese children. (16435024)	Leung T.F.... Lam C.W.	2006	DEFB1
20	Mannose-binding lectin 2 (MBL2) gene polymorphism in asthma and atopy among adults. (16178865)	Aittoniemi J.... Karjalainen J.	2005	MBL2
21	NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population. (15988535)	Poon A.H.... Schurr E.	2005	SLC11A1, IGES
22	The relationship of atopy, smoking, and sensitization to methyltetrahydrophthalic anhydride. (15345197)	Yokota K.... Morimoto K.	2004	IL13
23	A functional polymorphism in the promoter region of the cyclooxygenase-2 gene is not associated with asthma and atopy in an Australian population. (15544595)	Shi J.... Kedda M.A.	2004	PTGS2
24	Role of gender and hormone-related events on IgE, atopy, and eosinophils in the Epidemiological Study on the Genetics and Environment of Asthma, bronchial hyperresponsiveness and atopy. (15356546)	Siroux V.... Kauffmann F.	2004	IGHE
25	Variations in eosinophil chemokine responses: an investigation of CCR1 and CCR3 function, expression in atopy, and identification of a functional CCR1 promoter. (12794150)	Phillips R.M.... Sabroe I.	2003	CCR3, CCL11, CCR1
26	Smoking and atopy as determinants of sputum eosinophilia and bronchial hyper-responsiveness in adults with normal lung function. (12924523)	PetAoys T.... Haahtela T.	2003	MPO, RNASE3
27	Association of thromboxane A2 receptor (TBXA2R) with atopy and asthma. (12897758)	Shin H.D.... Park C.S.	2003	TBXA2R
28	A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. (12928861)	Wang M.... Yu L.-S.	2003	IL13
29	Association between antenatal cytokine production and the development of atopy and asthma at age 6 years. (14568741)	Macaubas C.... Holt P.G.	2003	IL4, IFNG
30	Transient suppression of atopy in early childhood is associated with high vaccination coverage. (12612285)	GrA1ber C.... Wahn U.	2003	IGES
31	The IL1A genotype associates with atopy in nonasthmatic adults. (12209090)	Karjalainen J.... Hurme M.	2002	IL1A
32	The impact of atopy on neutrophil activity in middle ear effusion from children and adults with chronic otitis media. (12003588)	Hurst D.S.... Venge P.	2002	MPO
33	Association of a promoter polymorphism of the CD14 gene and atopy. (11282774)	Koppelman G.H.... Bleecker E.R.	2001	CD14, IGHE
34	IL4-R1 (5q31-q33) and FcepsilonRI-betaca (11q13) markers and atopy: a case/control study in a spanish population. (11167377)	Torres-Galvan M.J.... Sanchez-Garcia F.	2001	IL4
35	The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (10733466)	Kruse S.... Deichmann K.A.	2000	PLA2G7
36	Positive atopy patch test reactions to Pityrosporum orbiculare in atopic dermatitis patients. (10606939)	Tengvall Linder M.... Wahlgren C.	2000	ICAM1
37	Hyperimmunoglobulinemia E in the absence of atopy and filarial infection: the Huaorani of Ecuador. (11191097)	Kron M.A.... Guzman J.R.	2000	IGHE
38	Studies on linkage and association of atopy with the chromosomal region 12q13-24. (11069563)	Heinzmann A.... Deichmann K.A.	2000	LTA4H, STAT6, KITLG
39	Delta 32 deletion of CCR5 gene and association with asthma or atopy. (11081537)	Mitchell T.J.... Cookson W.O.	2000	CCR5
40	Genetics and specific immune response in allergy to birch pollen and food: evidence of a strong, positive association between atopy and the HLA class II allele HLA-DR7. (10452762)	Senechal H.... Swierczewski E.	1999	HLA-DRB1, HLA-DPB1
41	Atopy, anergic status, and cytokine expression in HIV-infected subjects. (10329817)	Empson M.... Garsia R.	1999	IL2, IFNG
42	Atopy and interleukin-4 receptor (10434569)	Izuhara K.	1999	IL4, IL13, IL4R
43	Genetic studies of atopy and atopic dermatitis. (9039286)	Coleman R.... Harper J.I.	1997	CIITA
44	IgE levels, atopy markers and hay fever in relation to age, sex and smoking status in a normal adult Swiss population. SAPALDIA (Swiss Study on Air Pollution and Lung Diseases in Adults) Team. (8957114)	WA1thrich B.... Leuenberger P.	1996	IGHE
45	Basophil count in neonates is not suitable for atopy predictivity. (9015783)	Calbi M.... Triggiani M.	1996	IGHE
46	Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. (7666875)	Postma D.S.... Levitt R.C.	1995	IL9, IGHE
47	IgE antibodies to tetanus toxoid in relation to atopy. (7613125)	Aalberse R.C.... Wahn U.	1995	IGHE
48	Eosinophil cationic protein in nasal secretion and in serum and myeloperoxidase in serum in respiratory syncytial virus bronchiolitis: relation to asthma and atopy. (7841728)	Sigurs N.... Sigurbergsson F.	1994	MPO, RNASE3
49	Sinusitis and atopy in human immunodeficiency virus infection. (8421162)	Small C.B.... Rosenstreich D.L.	1993	IGHE
50	Levels of IgA and cow milk antibodies in breast milk vs. the development of atopy in children. Low colostral IgA associated with cow milk allergy. (1809019)	Savilahti E.... Siimes M.A.	1991	CD79A

Genes related to atopy according to GeneCards:

(show top 50)    (show all 200)

id	Symbol	Description	Score	GeneCards Section Context
1	MICU1	mitochondrial calcium uptake 1	11.1	Orthologs, Aliases & Descriptions
2	IL4R	interleukin 4 receptor	11.1	Summaries, Functions, Publications
3	HAVCR1	hepatitis A virus cellular receptor 1	11.1	Summaries, Publications
4	SPINK5	serine peptidase inhibitor, Kazal type 5	11.0	Publications, Summaries
5	SART1	squamous cell carcinoma antigen recognized by T cells	11.0	Publications, Summaries
6	MS4A2	membrane-spanning 4-domains, subfamily A, member 2	11.0	Publications
7	PLA2G7	phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)	11.0	Publications
8	SELP	selectin P (granule membrane protein 140kDa, antigen CD62)	11.0	Publications
9	IGES	immunoglobulin E concentration, serum	11.0	Publications
10	IGHE	immunoglobulin heavy constant epsilon	11.0	Publications
11	IL9	interleukin 9	11.0	Publications
12	LTC4S	leukotriene C4 synthase	11.0	Publications
13	TSLP	thymic stromal lymphopoietin	11.0	Publications
14	SOCS2	suppressor of cytokine signaling 2	11.0	Functions
15	PRG2	proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)	11.0	Publications
16	EPX	eosinophil peroxidase	11.0	Publications
17	IL13	interleukin 13	11.0	Publications
18	CMA1	chymase 1, mast cell	11.0	Publications
19	IL4	interleukin 4	11.0	Publications
20	IL13RA1	interleukin 13 receptor, alpha 1	11.0	Publications
21	SCGB1A1	secretoglobin, family 1A, member 1 (uteroglobin)	11.0	Publications
22	CYSLTR2	cysteinyl leukotriene receptor 2	11.0	Publications
23	LALBA	lactalbumin, alpha-	11.0	Publications
24	TPT1	tumor protein, translationally-controlled 1	11.0	Publications
25	RNASE3	ribonuclease, RNase A family, 3	11.0	Publications
26	CD14	CD14 molecule	11.0	Publications
27	CYSLTR1	cysteinyl leukotriene receptor 1	11.0	Publications
28	IL5RA	interleukin 5 receptor, alpha	11.0	Publications
29	IRF1	interferon regulatory factor 1	11.0	Publications
30	IL12RB2	interleukin 12 receptor, beta 2	11.0	Publications, UniProt Related
31	FCER2	Fc fragment of IgE, low affinity II, receptor for (CD23)	11.0	Publications
32	CCL17	chemokine (C-C motif) ligand 17	11.0
33	CCL11	chemokine (C-C motif) ligand 11	11.0	Publications
34	STAT6	signal transducer and activator of transcription 6, interleukin-4 induced	11.0	Publications
35	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	11.0	Publications
36	TBXA2R	thromboxane A2 receptor	11.0	Publications
37	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
38	CCL22	chemokine (C-C motif) ligand 22	11.0
39	SLC11A1	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	11.0	Publications
40	CCR3	chemokine (C-C motif) receptor 3	11.0	Publications
41	MIF	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	11.0	Publications
42	NOD2	nucleotide-binding oligomerization domain containing 2	11.0	Publications
43	FLG	filaggrin	11.0	Publications
44	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
45	IL12B	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	11.0	Publications
46	TLR9	toll-like receptor 9	11.0	Publications
47	CSN1S1	casein alpha s1	11.0
48	TLR4	toll-like receptor 4	11.0	Publications
49	TLR2	toll-like receptor 2	11.0	Publications
50	MPO	myeloperoxidase	11.0	Publications

Pathways related to atopy according to GeneDecks:

(show top 50)    (show all 179)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.7	IL15, IL16, IL2, IL3, IL9, CCL26
2	NFAT Signaling and Lymphocyte Interactions36	10.6	FCER2, IL12B, IL13, IL15, IL16, IL1A
3	Bacterial infections in CF airways41	10.5	RELA, CFTR, IRAK1, IRF1, TLR2
4	Regulation of eIF4 and p70S6K36	10.5	IL12B, IL13, IL15, IL16, IL18, IL1A
5	Immune System38	10.3	CIITA, JAK1, CD79A, IRF1, IRF2, FCGR1A
6	IL-6 Pathway36	10.3	IL10, IL12B, IL16, IL18, IL3, IL4
7	PGC1Alpha Pathway36	10.2	IL12B, IL13, IL15, IL16, IL18, IL1A
8	Jak-STAT signaling pathway20	10.1	JAK1, JAK2, IL10, IL12B, IL12RB2, IL13
9	Asthma20	10.1	MS4A2, IL10, IL13, IL3, IL4, IL5
10	Chemokine Signaling36	10.1	JAK2, IL8, CCL26, CCR2, CCL22, CCL2
11	Immune response_Bacterial infections in normal airways41	9.9	RELA, CFTR, JAK1, CD14, IRAK1, IRF1
12	Chemokine signaling pathway20	9.9	RELA, JAK2, ITK, IL8, CCL26, CCR2
13	Th1 Differentiation37	9.8	JAK1, JAK2, CD28, IL10, IL12B, IL12RB2
14	Measles20	9.8	RELA, JAK1, JAK2, CD28, IRAK1, IL12B
15	Molecular Mechanisms of Cancer36	9.7	KITLG, KDR, JAK1, FGFR1, FGFR2, FGFR4
16	THC Differentiation Pathway36	9.7	CD28, IL10, IL12B, IL12RB2, IL18, IL18R1
17	Endothelin-1 Signaling Pathway36	9.6	FLT1, FGFR2, FGFR4, IL10, IL12B, IL13
18	IL-21 Signaling and its Primary Biological Effects in Different Immune Cell Types37	9.6	IL12B, IL1B, IL4, IL4R, IL6, IL6R
19	Akt Signaling36	9.4	CD28, FGFR1, FGFR4, IL10, IL12B, IL13RA1
20	Th17 Differentiation37	9.4	JAK1, JAK2, CD28, IL12B, IL1B, IL6
21	ERK Signaling36	9.4	KITLG, FLT1, FGFR2, FGFR4, IL10, IL12B
22	SOCS Pathway36	9.3	JAK1, JAK2, IRS2, IL10, IL12B, IL13
23	Glucocorticoid Receptor Signaling36	9.2	IL10, IL12B, IL13, IL15, IL16, IL18
24	JNK Pathway36	9.0	KITLG, KDR, FLT1, FGFR1, FGFR2, FGFR4
25	PEDF Induced Signaling36	9.0	RELA, IL10, IL12B, IL13, IL15, IL16
26	Malaria20	8.9	SELP, IL10, IL18, IL1B, IL6, IL8
27	Cytokine production by Th17 cells in CF (Mouse model)41	8.9	RELA, CFTR, JAK2, CD14, FOXP3, IL12B
28	Hematopoietic cell lineage20	8.9	KITLG, MS4A1, CD14, FCER2, FCGR1A, IL1A
29	Tec Kinases Signaling36	8.9	KITLG, JAK1, JAK2, CD28, ITK, IRAK1
30	MIF Mediated Glucocorticoid Regulation36	8.8	CD14, MIF, IL10, IL12B, IL13, IL15
31	STAT3 Pathway36	8.8	JAK2, CD28, IL10, IL12B, IL12RB2, IL13
32	MIF Regulation of Innate Immune Cells36	8.8	CD14, MIF, IL10, IL12B, IL13, IL15
33	all-trans-Retinoic Acid Signaling in Brain36	8.7	IL10, IL12B, IL13, IL15, IL16, IL18
34	Toxoplasmosis20	8.7	RELA, CIITA, JAK1, JAK2, IRAK1, IL10
35	Cytokine Network36	8.7	IL10, IL12B, IL13, IL15, IL16, IL18
36	Leishmaniasis20	8.5	RELA, JAK1, JAK2, IRAK1, FCGR1A, IL10
37	Tuberculosis20	8.4	RELA, VDR, CIITA, JAK1, JAK2, CD14
38	TGF-Beta Pathway36	8.4	KITLG, KDR, FLT1, FGFR1, FGFR2, FGFR4
39	Influenza A20	8.3	RELA, CIITA, JAK1, JAK2, IL12B, IL18
40	JAK-STAT Pathway36	8.3	KITLG, KDR, JAK1, JAK2, FLT1, FGFR1
41	NF-KappaB (p50-p65) Pathway36	8.2	RELA, KITLG, KDR, IRAK1, IRAK3, FLT1
42	NF-KappaB Family Pathway36	8.2	RELA, KITLG, KDR, IRAK1, IRAK3, FLT1
43	Rho Family GTPases36	8.1	KITLG, KDR, FLT1, FGFR1, FGFR2, FGFR4
44	Chagas disease (American trypanosomiasis)20	8.0	RELA, IRAK1, IL10, IL12B, IL1B, IL2
45	PAK Pathway36	7.8	KITLG, KDR, FLT1, FGFR1, FGFR2, FGFR4
46	MAPK Family Pathway36	7.7	KITLG, KDR, FLT1, FGFR1, FGFR2, FGFR4
47	Antioxidant Action of Vitamin-C36	7.6	KITLG, KDR, JAK2, CD28, FLT1, FGFR1
48	p38 Signaling36	7.6	KITLG, KDR, CD28, IRAK1, IRAK3, FLT1
49	Cytokine-cytokine receptor interaction20	7.5	KITLG, VEGFA, KDR, FLT1, IL10, IL12B
50	Rheumatoid arthritis20	7.4	VEGFA, CD28, FLT1, IL15, IL18, IL1A

Compounds related to atopy according to GeneDecks:

(show top 50)    (show all 445)

id	Compound	Score	Top Affiliating Genes
1	sp 60012532 42	11.9	IL13, TLR2
2	cyclophosphamide32 34 9 9	13.8	BCL6, MS4A1, MBL2
3	ltc432	10.8	IL13, IL3, IL5, CCL11, PTGS1, CYSLTR1
4	ionomycin32	10.6	FCER2, IL3, IL5, IL9, CCL11, CCL3
5	budesonide32 42 9 9	13.6	KITLG, IL5RA, CCL11, IGHE, F2RL1, PTGS1
6	theophylline32 9 18 9	13.5	SELP, CD79A, IL10, IL13, IL16, IL2RA
7	ccl432	10.5	IL12B, IL13, IL15, IL16, CCL22, CCL2
8	histamine32 18	11.3	KITLG, SELP, CMA1, LALBA, MPO, CD79A
9	gp 13032	10.2	SCGB1A1, JAK1, JAK2, IL13, IL15, IL18R1
10	ifn-alpha32	9.9	JAK1, IRF1, IL10, IL13, IL18, IL2
11	aspartate32	9.9	SELP, VDR, SCGB1A1, CHRM3, LALBA, CFTR
12	pge232	9.7	CIITA, CFTR, CD14, FOXP3, IRF1, ARG1
13	tacrolimus32 34 9 9	12.6	VDR, CD28, CD79A, IL10, IL13, IL15
14	progesterone32 42 9 18 9	13.5	SCGB1A1, LALBA, IRS2, FLT1, FGFR1, FGFR2
15	tarc32	9.4	IL10, IL13, IL18, IL1A, IL4, IL4R
16	rantes32	9.4	KITLG, SELP, CIITA, CD14, IRAK1, IRF1
17	fmlp32	9.3	SELP, MPO, CD14, FCER2, FCGR1A, IL13
18	okt332	9.2	CD79A, FCER2, IL10, IL15, IL18R1, IL2
19	adenylate32	9.2	KITLG, SELP, VDR, CHRM3, CFTR, IRF1
20	rapamycin32 42	10.1	KITLG, VEGFA, KDR, JAK2, FOXP3, IRS2
21	doxorubicin32 34 9 9	12.1	KITLG, KDR, BCL6, CFTR, FLT1, MIF
22	imiquimod32 42 9 9	12.0	IL10, IL12B, IL18, IL1A, IL5, IL6
23	poly(i-c)32	9.0	IRF1, IL12B, IL15, IL18, IL1B, IL3
24	oxygen32 18	9.9	KITLG, SCGB1A1, CIITA, MPO, JAK2, IRAK1
25	polymyxin b32	8.7	CD14, IL10, IL1A, IL1B, IL1RN, IL4
26	paraffin32	8.6	RELA, KITLG, VEGFA, CMA1, KDR, BCL6
27	ccl332	8.6	IL10, IL13, IL15, IL18, IL1A, IL1B
28	phosphatidylinositol32	8.5	KITLG, KDR, SCGB1A1, CIITA, CHRM3, JAK1
29	cysteine32	8.4	SELP, NAT1, NAT2, VDR, CMA1, KDR
30	il-1232	8.4	IL10, IL12B, IL13, IL15, IL18, IL1B
31	aspirin32 34 18	10.4	KITLG, SELP, VDR, MTHFR, CFTR, JAK2
32	tgf beta132	8.3	KITLG, KDR, FOXP3, FLT1, IL10, IL13
33	cyclosporin a32 42	9.2	KITLG, SELP, VDR, CIITA, CHRM3, MTHFR
34	il 1032	8.2	VDR, IL10, IL12B, IL13, IL15, IL18
35	hydrocortisone32 9 9	10.2	KITLG, KDR, CD14, FLT1, MIF, FCER2
36	testosterone32 9 18 9	11.1	RELA, KITLG, VDR, MTHFR, CFI, CFTR
37	neopterin32	8.1	CD79A, CD14, FCER2, IL10, IL18, IL18R1
38	mip 1alpha32	8.1	IL10, IL13, IL1B, IL3, IL4, IL6
39	tyrosine32	7.7	KITLG, SELP, VEGFA, LILRB4, KDR, BCL6
40	creatinine32	7.7	KITLG, SELP, VDR, SCGB1A1, MTHFR, CFI
41	lactate32	7.4	KITLG, SELP, KDR, BCL6, MPO, CD79A
42	vegf32	7.3	KITLG, SELP, KDR, MPO, JAK2, CD14
43	ly29400232	7.2	VEGFA, IRS2, IL10, IL13, IL18, IL18R1
44	triptolide32	7.0	VEGFA, CD14, IL1B, IL2, IL6, IL8
45	15-deoxy-delta-12,14-prostaglandin j232	6.8	VEGFA, JAK1, JAK2, IL10, IL1B, IL4
46	cisplatin32 34 9 9	9.5	KITLG, VEGFA, KDR, MTHFR, CFI, CFTR
47	indomethacin32 9 9	8.3	KDR, CFTR, MPO, JAK2, CD79A, IL13
48	serine32	5.6	RELA, KITLG, VDR, CMA1, KDR, BCL6
49	actinomycin d32	5.5	KITLG, VEGFA, VDR, CIITA, CFTR, JAK2
50	dexamethasone32 42 34 9 9	9.1	KITLG, SELP, NAT2, VEGFA, VDR, KDR

Cellular components related to atopy according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	endosome	GO:005768	9.6	ADRB2, TLR9, ACE, CCR3, CCR5, IL15
2	external side of plasma membrane	GO:009897	9.3	IL4, CCR5, CCR1, IFNG, ICAM1, HLA-DRB1
3	integral to plasma membrane	GO:005887	8.8	SPN, CYSLTR1, TBXA2R, PTGDR2, TNFRSF14, TNF
4	cell surface	GO:009986	8.5	PLAU, NOD2, TLR2, TGFB1, TGFBR3, CX3CL1
5	cytosol	GO:005829	7.9	NQO1, SPINK5, TRAF2, HMOX1, IDO1, CCL3
6	extracellular region	GO:005576	7.1	CD14, MBL2, CCL22, CCL2, CCL11, CCL17
7	plasma membrane	GO:005886	6.5	CYSLTR2, CYSLTR1, SPN, CTLA4, CRLF2, PLAU
8	extracellular space	GO:005615	6.0	KITLG, IL1A, IL1B, IL1RL1, IL1RN, IL2

Biological processes related to atopy according to GeneDecks:

(show top 50)    (show all 124)

id	Name	GO ID	Score	Top Affiliating Genes
1	defense response to bacterium	GO:042742	10.9	LALBA, SLC11A1, SPN, PRG2, DEFB1, CFP
2	positive regulation of tumor necrosis factor production	GO:032760	10.9	TLR2, TLR9, IFNG, TLR4, IL18, NOD2
3	eosinophil chemotaxis	GO:048245	10.8	CCL5, CCL11, CCR3, CCL3, CCL24, CCL13
4	cell surface receptor signaling pathway	GO:007166	10.7	MIF, IL12RB2, IL13RA1, IL18RAP, IL2RA, CCL2
5	positive regulation of nitric-oxide synthase biosynthetic process	GO:051770	10.7	JAK2, FCER2, CCL2, KDR, TLR9, TLR2
6	positive regulation of B cell proliferation	GO:030890	10.6	IL2, IL13, IRS2, TLR4, IL5, MIF
7	positive regulation of inflammatory response	GO:050729	10.6	IL2, CCR2, CCL3, CCL24, PLA2G7, TLR2
8	innate immune response	GO:045087	10.6	TLR9, MAP3K5, CCR2, F2RL1, TRAF2, NOD2
9	chemokine-mediated signaling pathway	GO:070098	10.6	CX3CR1, CCL5, CCR1, CXCR3, CCR5, CCL2
10	chemotaxis	GO:006935	10.5	CCL26, CCR2, CCL22, CCL2, CCL11, CCR5
11	positive regulation of T cell proliferation	GO:042102	10.4	CD28, IL12B, IL15, IL1B, IL4, SPN
12	positive regulation of interleukin-17 production	GO:032740	10.4	TGFB1, NOD2, IL2, IL18, IL15, IL12B
13	negative regulation of interferon-gamma production	GO:032689	10.4	FOXP3, SCGB1A1, IL10, IL1RL1, HLA-DRB1, GATA3
14	cellular response to interferon-gamma	GO:071346	10.3	ARG2, IL18, CCL2, CCL3, CCL5, NOS2
15	negative regulation of growth of symbiont in host	GO:044130	10.3	MBL2, IL10, IL12B, IFNG, TNF, TLR2
16	response to lipopolysaccharide	GO:032496	10.3	IRAK1, SLC11A1, IRAK3, STAT5B, TLR4, LTA
17	cellular defense response	GO:006968	10.3	C5AR1, SPN, CCR5, CCR2, CX3CR1, IL4
18	elevation of cytosolic calcium ion concentration	GO:007204	10.2	C5AR1, CXCR3, CYSLTR1, F2RL1, CCR3, CCR2
19	cell-cell signaling	GO:007267	10.2	CCL3, LALBA, CCL18, CCL13, CCL5, GJB2
20	response to cholesterol	GO:070723	10.2	CCR5, TGFBR1, CCL5, TGFB1, CCL3, TGFBR2
21	positive regulation of interferon-gamma production	GO:032729	10.1	IL12B, CCR2, SLC11A1, TLR4, LTA, TNF
22	defense response to Gram-negative bacterium	GO:050829	10.1	SLC11A1, TLR4, NOS2, SELP, IL12B, IL6R
23	cellular calcium ion homeostasis	GO:006874	10.1	CCL3, VDR, TPT1, CCR2, CCL11, CCR1
24	cellular response to tumor necrosis factor	GO:071356	10.0	CCL3, GATA3, RELA, IRF1, ICAM1, CCL5
25	cellular response to lipopolysaccharide	GO:071222	10.0	ARG2, CX3CR1, TLR4, LTC4S, NOS2, IFNG
26	interferon-gamma-mediated signaling pathway	GO:060333	10.0	HLA-DRB1, STAT1, IFNG, JAK2, HLA-DPB1, IRF1
27	positive regulation of chemokine production	GO:032722	9.8	TLR4, TLR9, TLR2, TNF, IL6R, IL18
28	immune response	GO:006955	9.8	DEFB1, CCL17, CCR1, CCR5, CCL11, CCL22
29	cellular response to interleukin-1	GO:071347	9.8	CCL3, ICAM1, IL8, CCL5, CCL2, IRF1
30	lipopolysaccharide-mediated signaling pathway	GO:031663	9.7	STAT1, TGFB1, TLR4, TLR2, NOS3, TNF
31	positive regulation of angiogenesis	GO:045766	9.7	CX3CL1, KDR, VEGFA, CHI3L1, IL1A, CX3CR1
32	positive regulation of interleukin-6 production	GO:032755	9.6	IL1A, IL1B, IL6, NOD2, IL6R, TNF
33	signal transduction	GO:007165	9.5	IL15, IL18R1, KITLG, IL1RL1, IL4R, IL5RA
34	positive regulation of ERK1 and ERK2 cascade	GO:070374	9.5	TLR4, F2RL1, NOD2, FGFR2, CCL3, CCR1
35	positive regulation of cell migration	GO:030335	9.5	CCL11, CCL26, FLT1, CCL3, KDR, JAK2
36	positive regulation of peptidyl-tyrosine phosphorylation	GO:050731	9.4	JAK2, TNFRSF14, IL6R, KITLG, IL6, TLR4
37	humoral immune response	GO:006959	9.4	CCL2, IFNG, CD28, MS4A2, IL6, TNF
38	monocyte chemotaxis	GO:002548	9.4	FLT1, CCL3, CCL5, CCL2, IL6R, IL6
39	MAPK cascade	GO:000165	9.2	CCL3, TGFB1, TNF, CCL2, IL18, CCL5
40	positive regulation of nitric oxide biosynthetic process	GO:045429	9.2	PTGS2, ICAM1, JAK2, IL1B, IFNG, TNF
41	positive regulation of NF-kappaB transcription factor activity	GO:051092	9.1	TLR4, AGER, NOD2, TNF, ICAM1, IL6R
42	xenobiotic metabolic process	GO:006805	9.0	CYP27B1, NQO1, NAT2, GSTM1, CYP2D6, GSTP1
43	anti-apoptosis	GO:006916	9.0	RELA, MPO, IRAK1, GSTP1, IL10, IL1A
44	inflammatory response	GO:006954	8.9	TLR2, AGER, C4B, LTA4H, CYSLTR1, TBXA2R
45	positive regulation of smooth muscle cell proliferation	GO:048661	8.8	IL6R, CX3CL1, FLT1, STAT1, PTGS2, TNF
46	response to drug	GO:042493	8.8	TBXA2R, NOS3, LTA, LTC4S, TGFB1, IL10
47	cytokine-mediated signaling pathway	GO:019221	8.8	EGR1, HLA-DRB1, HLA-DQA1, HLA-DPB1, HLA-C, ICAM1
48	response to hypoxia	GO:001666	8.5	CX3CL1, STAT5B, TGFBR3, CCL2, TGFB1, TLR4
49	positive regulation of cell proliferation	GO:008284	8.3	IRS2, TGFBR1, TGFBR2, TGFB1, CSF2, ADRB2
50	positive regulation of transcription from RNA polymerase II promoter	GO:045944	8.0	IFNG, VEGFA, IL6, IL4, IL1B, IL1A

Molecular functions related to atopy according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytokine receptor activity	GO:004896	10.7	IL1RL1, IL13RA2, IL13RA1, IL12RB2, IL12B
2	chemokine receptor activity	GO:004950	10.5	CXCR3, CX3CR1, CCR3, CCR1, CCR5, CCR2
3	chemokine activity	GO:008009	10.3	CCL22, CCL2, CCL11, CCL17, CCL28, CCL3
4	receptor activity	GO:004872	10.1	CSF2RB, LILRB4, CHRM3, IL18R1, IL18RAP, ICAM1
5	tetrahydrobiopterin binding	GO:034617	10.0	NOS1, NOS2, NOS3
6	interleukin-1 receptor binding	GO:005149	10.0	TLR9, IL1RN, IL1B, IL1A
7	nitric-oxide synthase activity	GO:004517	9.7	NOS1, NOS2, NOS3
8	heparin binding	GO:008201	9.7	PRG2, TGFBR3, CCL5, CCL2, FGFR4, FGFR2
9	growth factor activity	GO:008083	9.1	IL5, IL6, IL9, TGFB1, CSF2, IL4
10	cytokine activity	GO:005125	9.0	KITLG, IL31, IL4, IL5, IL6, IL9
11	heme binding	GO:020037	8.9	CYP2D6, CYP27B1, NOS1, NOS2, NOS3, EPX
12	enzyme binding	GO:019899	8.8	IL6R, APOA1, HMOX1, TRAF2, PTGS2, CYP1A2
13	protein homodimerization activity	GO:042803	8.0	HMOX1, PTGS2, NR2C1, NOS2, TGFB1, TAP1
14	protein binding	GO:005515	4.8	ACE, EGR1, LTC4S, COL18A1, AGER, TLR2