MCID: ATP002
MIFTS: 55

Atopy malady

Genetic diseases (common) category

Summaries for Atopy

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Wikipedia:63 Atopy /? more...

MalaCards based summary: Atopy, also known as ige responsiveness, atopic, is related to asthma and dermatitis, and has symptoms including autosomal dominant inheritance, eczema and abnormality of metabolism/homeostasis. An important gene associated with Atopy is IL4R (interleukin 4 receptor), and among its related pathways are IL-4 Signaling and its Primary Biological Effects in Different Immune Cell Types and Cytokines and Inflammatory Response. The compounds omalizumab and formoterol have been mentioned in the context of this disorder. Affiliated tissues include testes, lung and t cells, and related mouse phenotypes are digestive/alimentary and integument.

Description from OMIM:45 147050

Aliases & Classifications for Atopy

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Sources:
45OMIM, 10diseasecard, 43Novoseek, 22GTR, 60UMLS
See all sources

Atopy, Aliases & Descriptions:

Name: Atopy 45 10 43 60
 
Ige Responsiveness, Atopic 45 22


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)


External Ids:

OMIM45 147050

Related Diseases for Atopy

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Diseases related to Atopy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 166)
idRelated DiseaseScoreTop Affiliating Genes
1asthma31.9IL13, PLA2G7
2dermatitis31.5CMA1, TSLP, MS4A2, IL4, IL13
3allergic rhinitis31.2IL13, IL4, RNASE3
4atopic dermatitis31.2SPINK5, FCER2, RNASE3, TSLP, IL4, IL13
5food allergy31.1RNASE3, EPX, IL4, IL13
6keratoconjunctivitis31.0IL13, RNASE3
7rhinitis30.9IL13, IL9, IL4, MS4A2, CMA1, EPX
8sinusitis30.8CYSLTR1, RNASE3, LTC4S
9urticaria30.8FCER2, RNASE3, LTC4S
10otitis media30.8CD14, RNASE3
11vernal keratoconjunctivitis30.7RNASE3, CMA1, IL4, IL13
12malaria30.7FCER2
13chronic rhinitis30.6RNASE3
14bronchiolitis30.6FCER2, RNASE3, IL4R, IL13
15bronchitis30.5IL9, RNASE3
16mastocytosis30.5IL13, IL9, CMA1
17churg-strauss syndrome30.5CYSLTR1, RNASE3
18netherton syndrome30.5TSLP, SPINK5
19esophagitis30.5IL13
20tetanus30.4IL4, IL9, IL13
21intrinsic asthma30.4IL4, RNASE3, FCER2
22skin disease30.2IL13, IL4, RNASE3, FCER2, SPINK5
23nephrotic syndrome30.2CD14, PLA2G7, IL13, IL4R
24b-cell lymphomas30.2FCER2, IL4R, CD14
25hodgkin lymphoma30.1SELP, IL9, IL13
26eosinophilia30.1CYSLTR1, FCER2, RNASE3, EPX, CD14, IL13
27bronchopulmonary dysplasia30.0RNASE3, PLA2G7
28rheumatoid arthritis29.9HAVCR1, FCER2, SELP, RNASE3, IL4, IL4R
29leukemia29.9FCER2, RNASE3, EPX, LTC4S, CD14, IL9
30myocardial infarction29.9CYSLTR2, SELP, PLA2G7, CD14
31allergic asthma28.9IL13, IL9, IL4R, IL4, MS4A2, TSLP
32kimura disease10.5RNASE3
33esophagitis, eosinophilic, 110.5TSLP
34conjunctivitis10.5RNASE3, MS4A2
35common cold10.5RNASE3
36parasitic helminthiasis infectious disease10.5RNASE3, IL13
37collagenous colitis10.5RNASE3
38onchocerciasis10.5RNASE3, EPX
39hyper-ige recurrent infection syndrome10.5RNASE3, IL4
40proctitis10.5RNASE3, EPX
41eosinophilic pneumonia10.4RNASE3, IL13
42lipoid nephrosis10.4IL13, IL4R, FCER2
43kaposi sarcoma10.4CYSLTR2, IL4R, CD14
44schistosomiasis10.4RNASE3, IL4, IL13
45allergic conjunctivitis10.4IL13, IL4, RNASE3
46extrinsic allergic alveolitis10.4FCER2, CD14
47uveitis10.4CD14, IL9, IL4
48cutaneous leishmaniasis10.4FCER2, IL4, IL13
49obesity10.4
50bullous pemphigoid10.4FCER2, RNASE3, IL13

Graphical network of the top 20 diseases related to Atopy:



Diseases related to atopy

Symptoms for Atopy

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Symptoms by clinical synopsis from OMIM:

147050

Clinical features from OMIM:

147050

HPO human phenotypes related to Atopy:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 eczema HP:0000964
3 abnormality of metabolism/homeostasis HP:0001939
4 asthma HP:0002099

Drugs & Therapeutics for Atopy

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Drug clinical trials:

Search ClinicalTrials for Atopy

Search NIH Clinical Center for Atopy

Genetic Tests for Atopy

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Genetic tests related to Atopy:

id Genetic test Affiliating Genes
1 Ige Responsiveness, Atopic22

Anatomical Context for Atopy

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MalaCards organs/tissues related to Atopy:

31
Testes, Lung, T cells, Skin, Breast, Endothelial, Thyroid, Neutrophil, Eye, Whole blood, Brain, Placenta, B cells

Animal Models for Atopy or affiliated genes

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MGI Mouse Phenotypes related to Atopy:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053819.5TSLP, IL4, IL4R, IL9, IL13, FCER2
2MP:00107719.2SPINK5, CYSLTR2, SELP, TSLP, IL4, IL4R
3MP:00053888.9HAVCR1, CYSLTR1, CYSLTR2, SELP, TSLP, IL4
4MP:00053768.6SPINK5, CYSLTR2, FCER2, SELP, TSLP, IL4
5MP:00053978.6HAVCR1, SPINK5, FCER2, SELP, EPX, CMA1
6MP:00053878.1LTC4S, HAVCR1, SPINK5, CYSLTR1, CYSLTR2, FCER2

Publications for Atopy

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Articles related to Atopy:

(show top 50)    (show all 815)
idTitleAuthorsYear
1
Risk of suicide for individuals reporting asthma and atopy in young adulthood: findings from the Glasgow Alumni study. (25596956)
2015
2
Changes in atopy prevalence and sibship effect in rural population at all ages. (25832475)
2015
3
Atopy and cause-specific mortality. (25220375)
2014
4
The immunomodulatory effect of probiotics beyond atopy: an update. (24256057)
2013
5
The role of hydrolysates for atopy prevention - con. (24299445)
2013
6
Soluble CD23 levels are inversely associated with atopy and parasite-specific IgE levels but not with polyclonal IgE levels in people exposed to helminth infection. (23689700)
2013
7
The Relationship between Maternal Atopy and Childhood Asthma in Pretoria, South Africa. (23724245)
2013
8
Relationship of secondhand smoke and infant lower respiratory tract infection severity by familial atopy status. (23706712)
2013
9
Atypical croup: association with airway lesions, atopy, and esophagitis. (22588730)
2012
10
Platycodon grandiflorus alleviates DNCB-induced atopy-like dermatitis in NC/Nga mice. (23087507)
2012
11
Asthma and atopy in children born by caesarean section: effect modification by family history of allergies - a population based cross-sectional study. (23153011)
2012
12
Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age. (21396408)
2011
13
Promoter polymorphisms of the CD14 gene are associated with atopy in Pakistani adults. (21905503)
2011
14
X-chromosome Forkhead Box P3 polymorphisms associate with atopy in girls in three Dutch birth cohorts. (20028375)
2010
15
Relationship of serum cholesterol levels to atopy in the US population. (20015326)
2010
16
Infant atopy and allergic diseases: an introduction to dietary aspects. (19645154)
2009
17
IL15 gene variants are not associated with asthma and atopy. (19133918)
2009
18
Helicobacter pylori and lung function, asthma, atopy and allergic disease--a population-based cross-sectional study in adults. (19109248)
2009
19
Eczematous skin reaction to atopy patch testing with cockroach in patients with atopic dermatitis. (19610259)
2009
20
Correlation between atopy and hypersensitivity reactions during therapy with three different TNF-alpha blocking agents in rheumatoid arthritis. (19473578)
2009
21
Atopy, home environment and the risk of childhood-onset type 1 diabetes: a population-based case-control study. (18547232)
2008
22
Maternal stress and perinatal programming in the expression of atopy. (19838310)
2008
23
Interleukin 13, CD14, pet and tobacco smoke influence atopy in three Dutch cohorts: the allergenic study. (18417506)
2008
24
High birth weight, asthma and atopy at the age of 16 yr. (18208461)
2008
25
Evaluation and clinical interpretation of hypergammaglobulinemia E: differentiating atopy from immunodeficiency. (18450128)
2008
26
Fractional exhaled nitric oxide in patients with atopic asthma: correct definitions of the terms atopy and asthma. (18681096)
2008
27
Association of prostaglandin-endoperoxide synthase 2 gene polymorphisms with asthma and atopy in Chinese children. (17573729)
2007
28
Atopy in early life and effect of a primary prevention program for asthma in a high-risk cohort. (17919706)
2007
29
The interaction of IL1A and endothelial nitric oxide synthase polymorphisms is associated with the degree of atopy. (16815170)
2006
30
Allergen-induced interleukin-9 production in vitro: correlation with atopy in human adults and comparison with interleukin-5 and interleukin-13. (16433854)
2006
31
NRAMP1 is not associated with asthma, atopy, and serum immunoglobulin E levels in the French Canadian population. (15988535)
2005
32
The environment and risk factors for atopy. (16216168)
2005
33
Increase of cerebrospinal fluid soluble interleukin-2 receptor index in a patient with atopy and syringohydromyelia. (16118894)
2005
34
Effects of dog ownership and genotype on immune development and atopy in infancy. (14767447)
2004
35
Determination of allergen-specific IgE in patients with atopy or allergy symptoms]. (12970591)
2003
36
Low molecular weight PTP-IL-4RA interaction in atopy predisposition. (12144546)
2002
37
Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. (11429321)
2001
38
Association of a promoter polymorphism of the CD14 gene and atopy. (11282774)
2001
39
Common polymorphisms and alternative splicing in the ILT3 gene are not associated with atopy. (10940079)
2000
40
Ethnic differences in genetic susceptibility to atopy and asthma in Singapore. (10976388)
2000
41
The Ile198Thr and Ala379Val variants of plasmatic PAF-acetylhydrolase impair catalytical activities and are associated with atopy and asthma. (10733466)
2000
42
An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS-90). (10887320)
2000
43
The polymorphisms S503P and Q576R in the interleukin-4 receptor alpha gene are associated with atopy and influence the signal transduction. (10233717)
1999
44
Association of a lymphotoxin alpha gene polymorphism and atopy in Italian families. (10227402)
1999
45
Two common polymorphisms in the coding part of the CD43 gene are not associated with atopy. (9876225)
1998
46
Interleukin-4 and the genetics of atopy. (9392706)
1997
47
Prevalence of allergic bronchopulmonary aspergillosis and atopy in adult patients with cystic fibrosis. (8769507)
1996
48
The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. (7797786)
1995
49
IL-4: a key cytokine in atopy. (7812882)
1994
50
Atopy in lichen simplex (neurodermatitis circumscripta). (4802403)
1973

Variations for Atopy

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Expression for genes affiliated with Atopy

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Search GEO for disease gene expression data for Atopy.

Pathways for genes affiliated with Atopy

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Pathways related to Atopy according to GeneCards Suite gene sharing:

(show all 17)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.2IL4R, IL4
210.1IL4, IL13
310.1LTC4S, CYSLTR1
4
Show member pathways
10.1CYSLTR1, CYSLTR2
5
Show member pathways
IL-9 Signaling Pathway36
Development Thrombopoietin regulated cell processes58
IL-7 Signaling Pathway36
Immune response IL 9 signaling pathway58
10.0IL9, IL4R, IL4
6
Show member pathways
10.0IL13, IL4R, IL4
710.0IL13, IL9, IL4
810.0IL4, IL9, IL13
9
Show member pathways
Development IGF RI signaling
Immune response IL 4 signaling pathway58
Signal transduction AKT signaling58
10.0FCER2, IL4, IL4R
109.9IL4, IL4R, IL9, IL13
119.8FCER2, SELP, IL4, IL4R
129.8CD14, IL4R, IL4, FCER2
13
Show member pathways
9.8CD14, IL4R, IL4, FCER2
14
Show member pathways
9.8IL4, IL4R, IL9, IL13, PLA2G7
15
Show member pathways
Type III interferon signaling36
9.7TSLP, IL4, IL4R, IL9, IL13
16
Show member pathways
9.4IL13, IL9, IL4R, IL4, MS4A2, EPX
17
Show member pathways
9.2FCER2, TSLP, IL4, IL4R, IL9, IL13

Compounds for genes affiliated with Atopy

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Compounds related to Atopy according to GeneCards Suite gene sharing:

(show top 50)    (show all 122)
idCompoundScoreTop Affiliating Genes
1omalizumab43 1211.4IL4, MS4A2, IL13
2formoterol43 28 1212.3IL4, IL13, RNASE3
3lte42810.2CYSLTR2, CYSLTR1
4zafirlukast43 28 1212.2CYSLTR2, CYSLTR1, RNASE3
5nedocromil sodium4310.2RNASE3, FCER2, IL4
6praziquantel43 1211.2RNASE3, IL4, IL13
7mk 57159 4311.2CYSLTR1, CYSLTR2, IL4
8bayu97732810.2CYSLTR1, CYSLTR2
9pentoxifylline43 1211.2SELP, IL13, IL4, CD14
10salmeterol43 49 28 1213.2RNASE3, EPX, IL13, IL4
11pranlukast43 28 1212.1CYSLTR1, CYSLTR2, RNASE3, IL4
12tarc4310.1IL4, IL13, TSLP, IL9, IL4R
13iralukast2810.1CYSLTR1, CYSLTR2
14[3h]ltd42810.1CYSLTR1, CYSLTR2
15budesonide43 49 1212.1SELP, RNASE3, EPX, IL13, IL4
16ltd44310.1CYSLTR1, CYSLTR2, IL13, LTC4S, RNASE3
17p0034310.0RNASE3, IL4R, IL13, CD14
18lte44310.0RNASE3, EPX, CYSLTR1, LTC4S, CYSLTR2
19txb24310.0CD14, PLA2G7, RNASE3, SELP, FCER2
20ltc44310.0CYSLTR1, LTC4S, RNASE3, EPX, IL13
21ionomycin4310.0IL4, IL4R, IL9, IL13, FCER2
22methacholine43 49 1212.0IL13, RNASE3, IL9, CD14, IL4
23p0024310.0CD14, LTC4S, RNASE3, EPX, PLA2G7
24n-methyl ltc42810.0CYSLTR1, CYSLTR2
25theophylline43 28 24 1213.0IL13, EPX, SELP, CYSLTR1, RNASE3
26prednisolone43 28 1212.0IL13, EPX, RNASE3, CD14
27salbutamol43 49 28 24 1214.0CYSLTR1, FCER2, IL13, EPX, RNASE3
28hydrocortisone43 2 59 1212.9CD14, IL4, FCER2, IL13
29pgd2439.9LTC4S, IL13, EPX, RNASE3, CYSLTR2, CYSLTR1
30montelukast43 49 28 1212.9CYSLTR1, CYSLTR2, IL4, IL13, LTC4S, RNASE3
31cyclosporin a43 28 5911.9CD14, SELP, RNASE3, IL13, IL4R, IL4
32baycyslt2289.8CYSLTR1, CYSLTR2
33rantes439.8CD14, SELP, RNASE3, IL4, IL4R, IL9
34cycloheximide439.7CD14, PLA2G7, IL13, IL4R, IL4, FCER2
35lactate439.7IL13, CD14, EPX, RNASE3, SELP, FCER2
36heparin43 28 24 1212.7CD14, EPX, CMA1, RNASE3, SELP, CYSLTR2
37fmlp439.7SELP, IL13, CYSLTR2, FCER2, RNASE3, EPX
38arachidonic acid43 28 24 1212.7SELP, LTC4S, CYSLTR1, CYSLTR2, EPX, IL4R
39aspirin43 49 28 2412.6SELP, RNASE3, IL4, PLA2G7, CYSLTR2, LTC4S
40nitric oxide43 24 1211.6IL9, FCER2, CYSLTR2, SELP, IL13, RNASE3
41cysteine439.5SELP, IL4, IL13, CD14, LTC4S, CMA1
42serine439.5SPINK5, CMA1, EPX, FCER2, IL4R, IL13
43leukotriene b443 59 2411.4PLA2G7, IL13, EPX, RNASE3, SELP, FCER2
44lipid439.4RNASE3, IL9, CYSLTR2, EPX, CYSLTR1, LTC4S
45allergens439.1IL4R, IL9, IL4, CD14, EPX, RNASE3
46calcium43 49 24 1212.1EPX, FCER2, LTC4S, CD14, CYSLTR2, CYSLTR1
47dexamethasone43 49 28 1212.1EPX, IL4, RNASE3, FCER2, CYSLTR1, SELP
48pge2439.1LTC4S, CD14, PLA2G7, IL13, IL4, EPX
49tyrosine438.8EPX, TSLP, IL4, IL4R, SELP, IL13
50histamine43 28 2410.8SELP, RNASE3, EPX, CMA1, IL4, FCER2

GO Terms for genes affiliated with Atopy

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Cellular components related to Atopy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:00098979.6IL13, IL4, MS4A2, SELP, FCER2
2extracellular regionGO:00055769.6CD14, PLA2G7, IL13, CMA1, RNASE3, SPINK5
3extracellular spaceGO:00056159.1SELP, TSLP, IL4, IL4R, IL9, IL13

Biological processes related to Atopy according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1regulation of proton transportGO:001015510.2IL4, IL13
2defense response to protozoanGO:004283210.2IL4R, IL4
3response to ethanolGO:004547110.0CD14, IL13, IL4
4positive regulation of macrophage activationGO:00430329.9IL13, IL4R
5positive regulation of angiogenesisGO:00457669.9CYSLTR1, CYSLTR2, CMA1
6immune responseGO:00069559.7CYSLTR2, MS4A2, IL4, IL4R, IL9, IL13
7inflammatory responseGO:00069549.7CD14, IL13, IL9, MS4A2, SELP, CYSLTR1

Molecular functions related to Atopy according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1lipopolysaccharide bindingGO:000153010.2CD14, SELP
2leukotriene receptor activityGO:000497410.0CYSLTR1, CYSLTR2
3IgE bindingGO:00198639.8MS4A2, FCER2
4cytokine activityGO:00051259.8IL13, IL9, IL4, TSLP

Products for genes affiliated with Atopy

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Sources for Atopy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet