Aliases & Classifications for Atopy

MalaCards integrated aliases for Atopy:

Name: Atopy 54 71 71 13 52 69
Hypersensitivity, Immediate 42
Ige Responsiveness, Atopic 29
Immediate Hypersensitivity 69
Atopic Hypersensitivity 71

Characteristics:

OMIM:

54
Inheritance:
autosomal dominant


HPO:

32
atopy:
Inheritance autosomal dominant inheritance


Classifications:



Summaries for Atopy

UniProtKB/Swiss-Prot : 71 Atopic hypersensitivity: A condition characterized by predisposition to develop hypersensitivity reactions. Atopic individuals can develop eczema, allergic rhinitis and allergic asthma.

MalaCards based summary : Atopy, also known as hypersensitivity, immediate, is related to churg-strauss syndrome and cow milk allergy, and has symptoms including asthma, eczema and increased ige level. An important gene associated with Atopy is IL4R (Interleukin 4 Receptor), and among its related pathways/superpathways are Innate Immune System and Cytokine Signaling in Immune system. The drugs Montelukast and Petrolatum have been mentioned in the context of this disorder. Affiliated tissues include skin, testes and lung, and related phenotypes are hematopoietic system and digestive/alimentary

Wikipedia : 72 Atopy is a predisposition toward developing certain allergic hypersensitivity... more...

Description from OMIM: 147050

Related Diseases for Atopy

Diseases related to Atopy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
id Related Disease Score Top Affiliating Genes
1 churg-strauss syndrome 31.6 IFNG IL4 IL5
2 cow milk allergy 30.3 IL13 IL4 IL4R
3 middle lobe syndrome 29.9 IFNG IL13 IL4
4 skin disease 29.7 IL12RB2 IL4R IL5 RNASE3
5 lymphoma 29.6 CDSN IFNG IL13 IL4 IL5 MS4A2
6 asthma 29.3 CHI3L1 HAVCR1 IFNG IGES IGHE IL13
7 peeling skin syndrome 1 10.9
8 asthma 2 10.8
9 asthma susceptibility 5 10.8
10 asthma-related traits 7 10.8
11 asthma 1 10.8
12 peeling skin syndrome 5 10.8
13 peeling skin syndrome 3 10.8
14 myoclonic astatic epilepsy 10.8 IFNG IL4
15 heart septal defect 10.7 CDSN RNASE3
16 cytoplasmic body myopathy 10.7 IL13 IL5
17 eye accommodation disease 10.7 IFNG IL4
18 bazex syndrome 10.7
19 platelet-activating factor acetylhydrolase deficiency 10.7
20 immunodeficiency 23 10.7
21 allergic angiitis 10.7
22 eosinophilic granulomatosis with polyangiitis 10.7
23 asthma-related traits 4 10.7
24 keratosis follicularis spinulosa decalvans 10.7
25 asthma-related traits 6 10.7
26 asthma-related traits 3 10.7
27 sternal cleft 10.6 IFNG IGHE
28 orbit alveolar rhabdomyosarcoma 10.6 IGHE IL4 IL5
29 dioctophymiasis 10.6 IL13 IL4 IL5
30 aortic arch interruption 10.6 IL13 IL5
31 acute interstitial pneumonia 10.5 IFNG IL4 SPINK5
32 cherry allergy 10.5 IL13 IL4 IL5
33 indian tick typhus 10.5 IFNG IL13
34 epididymis adenocarcinoma 10.5 IL13 IL4 IL5
35 gastroschisis 10.5 IFNG IL5
36 fungal gastritis 10.5 IL13 IL4 IL5
37 abdominal tuberculosis 10.5 IL13 IL4 IL5
38 glucose intolerance 10.5 IL13 IL4 IL5
39 thelaziasis 10.5 IFNG IL4
40 spindle cell variant squamous cell breast carcinoma 10.5 IL13 IL4 IL5
41 premature ovarian failure 12 10.5 IGHE IL4 RNASE3
42 anterior dislocation of lens 10.5 IL4 RNASE3
43 papillary follicular thyroid adenocarcinoma 10.5 IL5 RNASE3
44 marasmus 10.5 IL4 IL5 RNASE3
45 orbital plasma cell granuloma 10.5 IL4 IL5 RNASE3
46 goat milk allergy 10.5 IFNG IL13 IL4 IL4R
47 choroidal sclerosis 10.5 IGHE RNASE3
48 hypercementosis 10.5 IL13 IL5
49 toxic diffuse goiter 10.5 IL13 IL5 RNASE3
50 female urethral cancer 10.5 IL4 IL5 RNASE3

Graphical network of the top 20 diseases related to Atopy:



Diseases related to Atopy

Symptoms & Phenotypes for Atopy

Symptoms via clinical synopsis from OMIM:

54

Lab:
ige level control

Pulmonary:
hay fever
asthma

Skin:
eczema

Immunology:
atopic hypersensitivity


Clinical features from OMIM:

147050

Human phenotypes related to Atopy:

32
id Description HPO Frequency HPO Source Accession
1 asthma 32 HP:0002099
2 eczema 32 HP:0000964
3 increased ige level 32 HP:0003212

MGI Mouse Phenotypes related to Atopy:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 IL5 MS4A2 PGM3 PTGDR SPINK5 CD14
2 digestive/alimentary MP:0005381 9.8 IFNG IL12RB2 IL13 IL4 IL4R IL5
3 immune system MP:0005387 9.8 CD14 CHI3L1 IFNG IL12RB2 IL13 IL4
4 respiratory system MP:0005388 9.23 CD14 IFNG IL13 IL4 IL4R IL5

Drugs & Therapeutics for Atopy

Drugs for Atopy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 418)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4,Phase 3,Phase 2 158966-92-8 5281040
2
Petrolatum Approved Phase 4,Phase 1,Phase 2 8009-03-8
3
Omalizumab Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 242138-07-4
4
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2 50-24-8 5755
6
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 75614-87-8, 51-45-6 774
7
Desonide Approved, Investigational Phase 4,Phase 3 638-94-8 5311066
8
Betamethasone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1 378-44-9 9782
9
Pimecrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 137071-32-0 6447131 17753757
10
Tacrolimus Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 104987-11-3 445643 439492
11
Fluocinonide Approved, Investigational Phase 4 356-12-7 9642
12
Hydrocortisone Approved, Vet_approved Phase 4,Phase 2 50-23-7 5754 657311
13
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 22916-47-8 4189
14
Cortisone acetate Approved Phase 4,Phase 2 1950-04-4, 50-04-4 5745
15
Cetirizine Approved Phase 4,Phase 3,Phase 2 83881-51-0 2678
16
Levocetirizine Approved Phase 4,Phase 3 130018-77-8
17
Mupirocin Approved, Investigational, Vet_approved Phase 4 12650-69-0 446596
18
Glycerol Approved, Investigational Phase 4,Phase 3,Phase 1,Phase 2 56-81-5 753
19
Epinephrine Approved, Vet_approved Phase 4,Phase 2 51-43-4 5816
20 Racepinephrine Approved Phase 4,Phase 2
21
Triamcinolone Approved, Vet_approved Phase 4,Phase 2 124-94-7 31307
22
Hyaluronic acid Approved, Vet_approved Phase 4 9004-61-9 53477741 24759
23
Ipratropium Approved Phase 4 22254-24-6, 60205-81-4 43232
24
Budesonide Approved Phase 4 51333-22-3 63006 5281004
25
Benzocaine Approved Phase 4,Phase 3,Phase 1,Phase 2 1994-09-7, 94-09-7 2337
26
Desoximetasone Approved Phase 4 382-67-2 5311067
27
Prednisone Approved, Vet_approved Phase 4,Phase 2 53-03-2 5865
28
Alitretinoin Approved, Investigational Phase 4 5300-03-8 444795
29
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
30
Amoxicillin Approved, Vet_approved Phase 4 26787-78-0 33613 2171
31
Clarithromycin Approved Phase 4 81103-11-9 84029
32
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3 1406-16-2
33
Chitosan Approved, Nutraceutical Phase 4,Phase 2 9012-76-4 71853
34
Glucosamine Approved, Nutraceutical Phase 4 3416-24-8 439213
35 tannic acid Approved, Nutraceutical Phase 4,Phase 3,Phase 1,Phase 2
36
Cholecalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 67-97-0 6221 10883523 5280795
37
Ergocalciferol Approved, Nutraceutical Phase 4,Phase 2,Phase 3 50-14-6 5280793
38
Tretinoin Approved, Investigational, Nutraceutical Phase 4 302-79-4 5538
39
Butyric Acid Experimental Phase 4,Phase 2 107-92-6 264
40
BCG vaccine Investigational Phase 4
41
Lactitol Investigational Phase 4 585-86-4 3871
42 Anti-Asthmatic Agents Phase 4,Phase 3,Phase 2,Phase 1
43 Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
44 Hormones Phase 4,Phase 3,Phase 2,Phase 1
45 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Phase 2,Phase 1
46 Leukotriene Antagonists Phase 4,Phase 3,Phase 2
47 Respiratory System Agents Phase 4,Phase 3,Phase 2,Phase 1
48 Dermatologic Agents Phase 4,Phase 3,Phase 2,Phase 1
49 Emollients Phase 4,Phase 3,Phase 2,Phase 1
50 Anti-Allergic Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 811)

id Name Status NCT ID Phase Drugs
1 Does Treatment With Montelukast Improve Symptoms of Atopic Dermatitis in Children? Unknown status NCT02534467 Phase 4 Montelukast
2 Efficacy of KAM2904 Face Cream and KAM3008 Body Lotion Treatment in Children With Atopic Dermatitis (AD) Unknown status NCT01781663 Phase 4
3 Role of Anti-IgE in Severe Childhood Eczema Unknown status NCT02300701 Phase 4 Xolair;Placebo
4 Effect of Moisturizing Creams on Skin Barrier Function Unknown status NCT00771121 Phase 4 urea/lactic acid;Placebo
5 Efficacy of Systemic Glucocorticoid in the Treatment of Wheezing in Children Unknown status NCT00494624 Phase 4 prednisolone
6 Immunological Mechanisms of Oralair® in Patients With Seasonal Allergic Rhinitis Unknown status NCT02014623 Phase 4 Control
7 Effects of Pimecrolimus Cream 1% on the Molecular and Cellular Profile of Adult Male Patients With Atopic Dermatitis Completed NCT00117377 Phase 4 Pimecrolimus;Placebo
8 A Study Evaluating the Efficacy of Fluocinonide Cream 0.1% (Vanos) in Subjects With Atopic Dermatitis Completed NCT01049243 Phase 4 Fluocinonide Cream 0.1%
9 Open Label Study of Long Term Treatment of Pediatric Treatment of Atopic Dermatitis With Pimecrolimus Cream 1% Within a Usual Clinical Setting Completed NCT00509990 Phase 4 Pimecrolimus
10 Comparison of Pimecrolimus Cream 1% Twice-Daily to Once-Daily Dosing in the Management of Atopic Dermatitis in Pediatric Subjects Completed NCT00139581 Phase 4 Pimecrolimus;Pimecrolimus
11 Efficacy and Tolerability of New Topical Formulations in Subjects With Atopic Dermatitis Completed NCT02732314 Phase 4 Investigational OTC Cream;0.05% Desonide Cream
12 Adherence to Topical Hydrocortisone 17-butyrate 0.1% (Locoid®) Using Different Vehicles in Adults With Atopic Dermatitis Completed NCT00693693 Phase 4 hydrocortisone 17-butyrate 0.1% Cream preparation;hydrocortisone 17-butyrate 0.1% Ointment preparation;hydrocortisone 17-butyrate 0.1% Lipocream preparation
13 Efficacy Study of Montelukast in Atopic Dermatitis Induced by Food Allergens Completed NCT00557284 Phase 4 Montelukast;Placebo
14 Study to Evaluate the Safety and Efficacy of Alefacept (Amevive) in Subjects With Moderate to Severe Atopic Dermatitis Completed NCT00832585 Phase 4 Alefacept
15 Elidel-Study: Elidel in Patients With Atopic Dermatitis Completed NCT00180141 Phase 4 Elidel-Creme
16 Epiceram™ Device Versus Mid-Strength Topical Steroid (Fluticasone Propionate 0.05%) for Treatment of Atopic Dermatitis Completed NCT00616538 Phase 4 Fluticasone Propionate 0.05%
17 A Clinical Study in Children and Adolescents With Mild to Moderate Atopic Dermatitis Completed NCT00568412 Phase 4 Elidel
18 A Comparison Study Between Protopic (Tacrolimus) Ointment and Elidel (Pimecrolimus) Cream in Treating Subjects With Atopic Dermatitis Completed NCT00666302 Phase 4 tacrolimus ointment;pimecrolimus cream
19 Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Treating Pediatric Patients With Atopic Dermatitis Completed NCT00666159 Phase 4 tacrolimus ointment;pimecrolimus cream
20 Measuring Adherence to Topical Therapy in Children With Atopic Dermatitis and the Impact of a Return Visit Completed NCT00654355 Phase 4 tacrolimus ointment
21 Comparison Study Between Protopic (Tacrolimus Ointment) and Elidel (Pimecrolimus Cream) in Pediatric Patients With Mild Atopic Dermatitis Completed NCT00667160 Phase 4 tacrolimus ointment;pimecrolimus cream
22 Reconstitution With Pimecrolimus Cream 1% of Steroid-damaged Skin in Adults With Atopic Dermatitis Completed NCT00367393 Phase 4 Pimecrolimus cream 1%
23 Efficacy of Desonide (Desonatetm) Gel 0.05% in Younger and Older Subjects With Atopic Dermatitis Completed NCT00690833 Phase 4 topical desonide hydrogel 0.05%
24 Pimecrolimus Cream 1% (Elidel®) and Medicated Device Cream (EletoneTM) in the Treatment and Maintenance of Atopic Dermatitis. Completed NCT01177566 Phase 4 pimecrolimus
25 An Efficacy and Safety Study of Tacrolimus Ointment in Adult Participants With Atopic Dermatitis Completed NCT01828879 Phase 4 Tacrolimus
26 An Efficacy and Safety Study of Tacrolimus Ointment in Pediatric Participants With Atopic Dermatitis Completed NCT01782729 Phase 4 Tacrolimus
27 Pimecrolimus Cream 1% Plus Topical Corticosteroid in Patients (2-17 Years of Age) With Severe Atopic Dermatitis Completed NCT00121381 Phase 4 Pimecrolimus plus topical corticosteroid (TCS);Pimecrolimus vehicle (Placebo) plus topical corticosteroid (TCS)
28 Management of Pruritus With Xyzal in Atopic Dermatitis Completed NCT00884325 Phase 4 Levocetirizine dihydrochloride (Xyzal);placebo
29 Evaluation of Cetaphil Advanced Usage to Control Light to Moderate Atopic Dermatitis, in Attempt to Reduce the Necessity of Topic Corticoids Application Completed NCT01063218 Phase 4
30 Epiceram Versus Elidel for Treatment of Mild to Moderate Atopic Dermatitis Completed NCT00460083 Phase 4 Elidel(R) (pimecrolimus 1%)
31 Efficacy and Safety of Pimecrolimus Cream 1% in Patients (2 to 11 Years Old) With Mild to Moderate Facial Atopic Dermatitis Completed NCT00130364 Phase 4 Pimecrolimus;Placebo
32 Analysis of the Quality of Life, the Clinical Effectiveness and Cost-effectiveness of a Novel Educational Programme in Patients With Psoriasis and Atopic Dermatitis Completed NCT01077882 Phase 4
33 A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis Completed NCT00484003 Phase 4 Pimecrolimus cream 1%
34 Prednisolone vs. Ciclosporine in Severe Atopic Eczema Completed NCT00445081 Phase 4 Prednisolone;Ciclosporine A
35 Protopic Ointment in Children Atopic Eczema Completed NCT00689832 Phase 4 Tacrolimus 0.03%;Fluticasone 0.005%
36 Locobase® REPAIR Used as an Adjunctive to Standard Therapy in Children With Moderate to Severe Atopic Dermatitis Completed NCT00673725 Phase 4 Locobase® REPAIR
37 Protopic Ointment in Adult Atopic Eczema of the Face Completed NCT00690105 Phase 4 tacrolimus 0.1%;fluticasone 0.005 %
38 Combination Therapy for Atopic Dermatitis Completed NCT00119158 Phase 4 Combination of pimecrolimus and fluticasone;pimecrolimus
39 Open-label Study to Investigate Systemic Exposure in Adult and Pediatric Atopic Dermatitis Patients Treated 8.5 Days With Pimecrolimus Cream 1% Under Occlusion Completed NCT00925730 Phase 4 Pimecrolimus
40 Study to Determine the Effect of an Anti-IgE Agent on Inflammatory Cells in the Skin of Atopic Dermatitis Patients Completed NCT00822783 Phase 4 Omalizumab;Placebo
41 Cetaphil Restoraderm Effect on Young Children With Atopic Dermatitis Completed NCT02589392 Phase 4
42 A Multi-Center Study of Short and Long-term Use of Protopic Ointment in Patients With Atopic Dermatitis Completed NCT00106496 Phase 4 Protopic;Corticosteroid;placebo
43 A Study to Investigate the Use of Hydrogel Vehicle in Maintaining the Skin Barrier in Persons With Atopic Dermatitis Completed NCT01065714 Phase 4 Hydrogel vehicle;Eucerin Lotion
44 Trial on Effectiveness Combined Probiotics in Atopic Dermatitis in Children Completed NCT02519556 Phase 4 Probiatop;Placebo
45 Safety and Efficacy of Pimecrolimus Cream 1% in Mild to Moderate Head and Neck Atopic Dermatitis (AD) Patients Completed NCT00121316 Phase 4 Pimecrolimus;Placebo
46 Preventive Treatment of Tacrolimus Ointment in Children With Atopic Dermatitis Completed NCT01745159 Phase 4 tacrolimus
47 The Impact of Treating Staphylococcus Aureus Infection and Colonization on the Clinical Severity of Atopic Dermatitis Completed NCT00179959 Phase 4 Sodium hypochlorite (bleach) baths;Mupirocin ointment;Water;Petrolatum Ointment
48 Comparison of the Efficacy and Safety of Two Topical Creams for Pediatric Atopic Dermatitis Completed NCT00828412 Phase 4 Desonide Cream 0.05%
49 Efficacy and Safety Study of Advantan for Maintenance Treatment of Atopic Dermatitis Completed NCT00185510 Phase 4 Methylprednisolone Aceponate (Advantan, BAY86-4862);Placebo
50 Efficacy and Safety of Pimecrolimus Cream 1% in Patients ≥ 3 Months of Age With Mild or Moderate Atopic Dermatitis Completed NCT00150059 Phase 4 Pimecrolimus Cream 1%

Search NIH Clinical Center for Atopy

Inferred drug relations via UMLS 69 / NDF-RT 48 :


Cochrane evidence based reviews: hypersensitivity, immediate

Genetic Tests for Atopy

Genetic tests related to Atopy:

id Genetic test Affiliating Genes
1 Ige Responsiveness, Atopic 29

Anatomical Context for Atopy

MalaCards organs/tissues related to Atopy:

39
Skin, Testes, Lung, Colon, T Cells, Breast, Heart

Publications for Atopy

Articles related to Atopy:

(show top 50) (show all 939)
id Title Authors Year
1
Co-occurrence of migraine and atopy in children and adolescents: myth or a casual relationship? ( 28248699 )
2017
2
Atopy in Elite Endurance Athletes. ( 28708708 )
2017
3
Polymorphisms in DENND1B gene are associated with asthma and atopy phenotypes in Brazilian children. ( 28668455 )
2017
4
Type 1 diabetes in children and adolescents is not associated with a reduced prevalence of atopy and allergic diseases. ( 28239959 )
2017
5
Window-of-opportunity: neonatal gut microbiota and atopy. ( 28653002 )
2017
6
Does atopy affect the course of viral pneumonia? ( 28634031 )
2017
7
Atopy and prostate cancer: Is there a link between circulating levels of IgE and PSA in humans? ( 28795218 )
2017
8
Atopy, asthma, and the elderly: A paradigm for personalized therapy. ( 28441985 )
2017
9
Influence of Atopy in the Outcome of Avulsed and Replanted Teeth during 5 Years of Follow-up. ( 27939740 )
2017
10
Persistent asthma phenotype related with late-onset, high atopy, and low socioeconomic status in school-aged Korean children. ( 28231776 )
2017
11
Association of atopy phenotypes with new development of asthma and bronchial hyperresponsiveness in school-aged children. ( 28364972 )
2017
12
Exhaled nitric oxide atopy, and spirometry in asthma and rhinitis patients in India. ( 28871585 )
2017
13
Helicobacter, Hygiene, Atopy, and Asthma. ( 28642748 )
2017
14
Correlation Between Idiopathic Nephrotic Syndrome and Atopy in Children - Short Review. ( 28878838 )
2017
15
Selected comorbidities of atopic dermatitis: Atopy, neuropsychiatric, and musculoskeletal disorders. ( 28709566 )
2017
16
IL33 and IL1RL1 variants are associated with asthma and atopy in a Brazilian population. ( 28266165 )
2017
17
The risk of autoimmune connective tissue diseases in patients with atopy: A nationwide population-based cohort study. ( 28814359 )
2017
18
Childhood atopy and mental health: a prospective, longitudinal investigation. ( 27762174 )
2017
19
Patterns of Immune Development in Urban Preschoolers with Recurrent Wheeze and/or Atopy. ( 28089873 )
2017
20
Life-course of atopy and allergy-related disease events in tropical sub-Saharan Africa: A birth cohort study. ( 28339128 )
2017
21
Association between infection with Helicobacter pylori and atopy in young Ethiopian children: A longitudinal study. ( 28787771 )
2017
22
A novel role for cilia function in atopy: ADGRV1 and DNAH5 interactions. ( 28927820 )
2017
23
ERBIN deficiency links STAT3 and TGF-I^ pathway defects with atopy in humans. ( 28126831 )
2017
24
Risk Factors for Keratoconus: Atopy and Eye Rubbing. ( 27755195 )
2017
25
Environmental control measures for the management of atopy. ( 28153081 )
2017
26
Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren. ( 28378554 )
2017
27
Serum IL-10, IL-17 and IL-23 levels as "bioumoral bridges" between dyslipidemia and atopy. ( 28692864 )
2017
28
Wheezing, asthma, and atopy in premature infants at 2 years of age. ( 28425254 )
2017
29
Atopy as a risk factor for subclinical hypothyroidism development in children. ( 28727568 )
2017
30
The influence of gender and atopy in the relationship between obesity and asthma in childhood. ( 28126313 )
2017
31
Correction: ERBIN deficiency links STAT3 and TGF-I^ pathway defects with atopy in humans. ( 28289052 )
2017
32
Prediction of atopy via total immunoglobulin E levels andskin prick tests in patients with psoriasis. ( 28425249 )
2017
33
Is there any difference regarding atopy between children with familial Mediterranean fever and healthy controls? ( 28465037 )
2017
34
Vitamin D Status, Lung Function and Atopy in Children with Asthma. ( 28599691 )
2017
35
Association of atopy and tentative diagnosis of skin cancer - results from occupational skin cancer screenings. ( 28681396 )
2017
36
Timing of food introduction and atopy prevention. ( 28709571 )
2017
37
Extract of Polygala tenuifolia Alleviates Stress-Exacerbated Atopy-Like Skin Dermatitis through the Modulation of Protein Kinase A and p38 Mitogen-Activated Protein Kinase Signaling Pathway. ( 28106783 )
2017
38
Free 25(OH)D concentrations are associated with atopy and lung function in children with asthma. ( 28533007 )
2017
39
Vitamin D and Atopy. ( 28454657 )
2017
40
Combined immunodeficiency and atopy caused by a dominant negative mutation in caspase activation and recruitment domain family member 11 (CARD11). ( 28826773 )
2017
41
Down-Regulation of Cough during Exercise Is Less Frequent in Healthy Children than Adults. Role of the Development and/or Atopy? ( 28567019 )
2017
42
Skin disease of penis and male genitalia is linked to atopy and circumcision: caseload in a male genital dermatology clinic. ( 27170096 )
2016
43
Analysis of the impact of allergy and atopy on new onset of uveitis. ( 27682154 )
2016
44
Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment. ( 27838347 )
2016
45
Early-life farm exposures and adult asthma and atopy in the Agricultural Lung Health Study. ( 27845237 )
2016
46
Probiotics for Prevention of Atopy and Food Hypersensitivity in Early Childhood: A PRISMA-Compliant Systematic Review and Meta-Analysis of Randomized Controlled Trials. ( 26937896 )
2016
47
Atopy patch test in children with atopic dermatitis. ( 27979025 )
2016
48
"Cumulative Stress": The Effects of Maternal and Neonatal Oxidative Stress and Oxidative Stress-Inducible Genes on Programming of Atopy. ( 27504149 )
2016
49
The Developmental History of IgE and IgG4 Antibodies in Relation to Atopy, Eosinophilic Esophagitis, and the Modified TH2 Response. ( 27221343 )
2016
50
Association of the chromosome 11p13.5 variant and atopic dermatitis with a family history of atopy in the Chinese Han population. ( 27007831 )
2016

Variations for Atopy

Expression for Atopy

Search GEO for disease gene expression data for Atopy.

Pathways for Atopy

Pathways related to Atopy according to GeneCards Suite gene sharing:

(show all 26)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 CD14 CHI3L1 IFNG IGHE IL12RB2 IL13
2
Show member pathways
13.26 IFNG IGHE IL12RB2 IL13 IL4 IL4R
3
Show member pathways
12.78 IFNG IL13 IL4 IL5 MS4A2 RNASE3
4
Show member pathways
12.54 IFNG IGHE IL12RB2 IL4 IL4R MS4A2
5
Show member pathways
12.51 IGHE IL13 IL4 IL5 MS4A2
6
Show member pathways
12.49 IFNG IL12RB2 IL13 IL4 IL4R IL5
7
Show member pathways
12.22 IFNG IL13 IL4 IL5
8
Show member pathways
12.08 IFNG IL13 IL4 IL5
9 11.92 CD14 IFNG IL4 IL5
10 11.89 IGHE IL13 IL4 IL4R
11
Show member pathways
11.87 IFNG IL12RB2 IL13 IL4 IL4R IL5
12
Show member pathways
11.86 IFNG IL12RB2 IL4
13 11.81 CD14 IL4 IL4R IL5
14
Show member pathways
11.8 IFNG IL4 IL4R
15 11.71 IFNG IL13 IL4 IL5
16
Show member pathways
11.66 IFNG IL4 IL5
17 11.56 IL13 IL4 IL5
18 11.56 IGHE IL4 IL4R IL5
19 11.56 IFNG IL12RB2 IL13 IL4 IL5
20 11.25 IFNG IL4 IL4R IL5
21 11.21 IFNG IL13 IL4 IL5
22 11.15 IFNG IL13 IL4 IL5
23 11.04 IFNG IL13 IL4 IL5
24 10.94 IL4 IL4R
25 10.77 IFNG IL12RB2 IL13 IL4 IL4R IL5
26 10.43 IL13 IL4 IL4R IL5

GO Terms for Atopy

Cellular components related to Atopy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 CD14 CHI3L1 IFNG IL13 IL4 IL4R
2 extracellular region GO:0005576 9.7 CD14 CHI3L1 IFNG IGHE IL13 IL4
3 external side of plasma membrane GO:0009897 9.17 CD14 IFNG IGHE IL12RB2 IL13 IL4

Biological processes related to Atopy according to GeneCards Suite gene sharing:

(show all 16)
id Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.83 CD14 IFNG IL12RB2 MS4A2
2 inflammatory response GO:0006954 9.73 CD14 CHI3L1 IL13 IL5 MS4A2 PTGDR
3 positive regulation of B cell proliferation GO:0030890 9.61 IL13 IL4 IL5
4 positive regulation of myoblast fusion GO:1901741 9.56 IL4 IL4R
5 positive regulation of macrophage activation GO:0043032 9.55 IL13 IL4R
6 microglial cell activation GO:0001774 9.54 IL13 IL4
7 positive regulation of isotype switching to IgG isotypes GO:0048304 9.51 IFNG IL4
8 defense response to protozoan GO:0042832 9.5 IFNG IL4 IL4R
9 immune response GO:0006955 9.5 IFNG IGHE IL13 IL4 IL4R IL5
10 positive regulation of chemokine biosynthetic process GO:0045080 9.49 IFNG IL4
11 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 IFNG IL4
12 positive regulation of MHC class II biosynthetic process GO:0045348 9.46 IFNG IL4
13 regulation of proton transport GO:0010155 9.4 IL13 IL4
14 negative regulation of complement-dependent cytotoxicity GO:1903660 9.37 IL13 IL4
15 positive regulation of mast cell degranulation GO:0043306 9.33 IL13 IL4 IL4R
16 positive regulation of immunoglobulin production GO:0002639 8.8 IL13 IL4 IL4R

Molecular functions related to Atopy according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IFNG IL13 IL4 IL5

Sources for Atopy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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