MCID: ATR057
MIFTS: 52

Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

MalaCards integrated aliases for Atrioventricular Block:

Name: Atrioventricular Block 12 28 51 41 14 69
Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050820
ICD10 32 I44.3 I44.30
ICD9CM 34 426.10
MeSH 41 D054537
NCIt 46 C26703
UMLS 69 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to second-degree atrioventricular block and third-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Cardiac conduction. The drugs Enfuvirtide and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, atrioventricular node and kidney, and related phenotypes are Decreased shRNA abundance and cardiovascular system

Wikipedia : 72 Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 181)
# Related Disease Score Top Affiliating Genes
1 second-degree atrioventricular block 34.3 HCN4 LMNA
2 third-degree atrioventricular block 33.5 HCN4 KCNE2 NPPB SCN5A
3 inferior myocardial infarction 30.6 NPPB PIK3C2A
4 sick sinus syndrome 30.6 HCN4 LMNA SCN5A
5 syncope 30.5 KCNH2 KCNQ1 NPPB SCN5A
6 cardiogenic shock 30.2 NPPB PIK3C2A
7 transposition of the great arteries 30.1 GATA4 NKX2-5 NPPB
8 cardiac conduction defect 30.1 KCNH2 SCN5A
9 right bundle branch block 30.0 HCN4 SCN5A TRPM4
10 atrial standstill 1 29.8 LMNA NPPB SCN5A
11 ventricular septal defect 29.7 GATA4 NKX2-5 NPPB TBX5
12 atrial heart septal defect 29.7 GATA4 NKX2-5 TBX5
13 left ventricular noncompaction 29.6 HCN4 KCNQ1 LMNA SCN5A
14 cardiac arrest 29.5 KCNQ1 PIK3C2A SCN5A
15 ventricular fibrillation, paroxysmal familial, 1 29.2 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
16 tetralogy of fallot 28.8 GATA4 KCNH2 NKX2-5 NPPB TBX5
17 long qt syndrome 28.8 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
18 atrial fibrillation 28.6 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 NPPB
19 dilated cardiomyopathy 27.9 CRYAB GATA4 KCNQ1 LMNA NKX2-5 NPPB
20 heart disease 27.0 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
21 first-degree atrioventricular block 12.6
22 mobitz type ii atrioventricular block 12.3
23 heart block, congenital 11.6
24 progressive familial heart block, type ia 11.3
25 myocardial infarction 10.4
26 familial short qt syndrome 10.3 KCNH2 KCNQ1
27 myocarditis 10.3
28 familial sick sinus syndrome 10.3 HCN4 SCN5A
29 cardiomyopathy, dilated, 1e 10.3 LMNA NKX2-5 SCN5A
30 cardiac conduction disease with or without dilated cardiomyopathy 10.3 KCNH2 KCNQ1 SCN5A
31 long qt syndrome 13 10.3 KCNH2 KCNQ1 SCN5A
32 cardiac sarcoidosis 10.3
33 ventricular tachycardia, catecholaminergic polymorphic, 1, with or without atrial dysfunction and/or dilated cardiomyopathy 10.2 KCNH2 KCNQ1 SCN5A
34 acute myocarditis 10.2
35 andersen cardiodysrhythmic periodic paralysis 10.2 KCNE2 KCNQ1 SCN5A
36 timothy syndrome 10.2 KCNE1 KCNH2 KCNQ1
37 long qt syndrome 9 10.2 HCN4 SCN5A
38 ebstein anomaly 10.1 GATA4 NKX2-5 NPPB
39 arrhythmogenic right ventricular dysplasia, familial, 5 10.1 NKX2-5 SCN5A
40 progressive familial heart block, type ib 10.1
41 endocarditis 10.1
42 myopathy 10.1
43 progressive familial heart block 10.1 SCN5A TRPM4
44 sinoatrial node disease 10.1 HCN4 SCN5A
45 blood group, i system 10.1
46 familial progressive cardiac conduction defect 10.0 NKX2-5 SCN5A TRPM4
47 pulmonary valve stenosis 10.0 GATA4 TBX5
48 toxic myocarditis 10.0 NPPB PIK3C2A
49 kearns-sayre syndrome 10.0
50 restrictive cardiomyopathy 10.0

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Aortic Valve Disease 1
Chronic Myocardial Ischemia Deficiency Anemia
Familial Atrial Fibrillation First-Degree Atrioventricular Block
Heart Disease Hypertension, Essential
Intermediate Coronary Syndrome Ischemic Heart Disease
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

GenomeRNAi Phenotypes related to Atrioventricular Block according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance GR00297-A 8.92 KCNQ1 PIK3C2A TRPM4 KCNH2

MGI Mouse Phenotypes related to Atrioventricular Block:

43
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.96 PIK3C2A SCN5A TBX5 TRPM4 GATA4 HCN4
2 growth/size/body region MP:0005378 9.81 GATA4 KCNE2 KCNH2 KCNQ1 LMNA NKX2-5
3 muscle MP:0005369 9.61 CRYAB GATA4 HCN4 KCNH2 KCNQ1 LMNA
4 normal MP:0002873 9.17 GATA4 HCN4 KCNQ1 LMNA NKX2-5 SCN5A

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 107)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enfuvirtide Approved, Investigational Phase 4 159519-65-0 16130199
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Heparin Approved, Investigational Phase 4 9005-49-6 46507594 772
4
Nicorandil Approved, Investigational Phase 4 65141-46-0 47528
5
Ticagrelor Approved Phase 4 274693-27-5 9871419
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
9
Moxifloxacin Approved, Investigational Phase 4 151096-09-2, 354812-41-2 152946
10
Norgestimate Approved, Investigational Phase 4 35189-28-7 6540478
11
Ofloxacin Approved Phase 4 82419-36-1 4583
12
Metoprolol Approved, Investigational Phase 4 51384-51-1, 37350-58-6 4171
13
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
14
Amiloride Approved Phase 4 2609-46-3, 2016-88-8 16231
15
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
16
Ramipril Approved Phase 4 87333-19-5 5362129
17
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
18
Atenolol Approved Phase 4 29122-68-7 2249
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
20 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
21 Antihypertensive Agents Phase 4,Phase 3
22 calcium heparin Phase 4
23 Micronutrients Phase 4
24 Platelet Aggregation Inhibitors Phase 4,Phase 2
25 Trace Elements Phase 4
26 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Vitamin B Complex Phase 4,Phase 2
28 Vitamins Phase 4
29 Anti-Infective Agents Phase 4,Phase 3,Phase 2
30 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
31 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Anti-Bacterial Agents Phase 4
33 Contraceptive Agents Phase 4
34 Contraceptives, Oral Phase 4
35 Contraceptives, Oral, Combined Phase 4
36 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
37 Cytochrome P-450 Enzyme Inhibitors Phase 4
38 Estradiol 17 beta-cypionate Phase 4
39 Estradiol 3-benzoate Phase 4
40 Estradiol valerate Phase 4 979-32-8
41 Norgestimate, ethinyl estradiol drug combination Phase 4
42 Polyestradiol phosphate Phase 4
43 Renal Agents Phase 4,Phase 2
44 Topoisomerase Inhibitors Phase 4
45 Adrenergic Agents Phase 4,Phase 3
46 Adrenergic Antagonists Phase 4,Phase 3
47 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 3
48 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2
49 Autonomic Agents Phase 4,Phase 3
50 Sympatholytics Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 95)

# Name Status NCT ID Phase Drugs
1 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
2 Ventricular Pacing Site Selection (V-PASS) Unknown status NCT00292383 Phase 4
3 Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
4 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
5 Comparative Study Between Cryoablation and Radiofrequency Ablation in the Treatment of Supraventricular Tachycardia Unknown status NCT01584154 Phase 4
6 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4 Nicorandil;normal saline
7 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Unknown status NCT02509754 Phase 4
8 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
9 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
10 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
11 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
12 Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication Completed NCT00562107 Phase 4
13 Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia Completed NCT00875914 Phase 4
14 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4 Avelox (Moxifloxacin, BAY12-8039);Levofloxacin
15 Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial. Completed NCT01311700 Phase 4 Injectable (i.v.) metoprolol tartrate (up to 15 mg).
16 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Recruiting NCT02482844 Phase 4
17 Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Recruiting NCT02832973 Phase 4 Spironolactone;Furosemide,;Amiloride;Ramipril;Bisoprolol
18 Evaluation of Decreased Usage of Betablockers After Myocardial Infarction in the SWEDEHEART Registry (REDUCE-SWEDEHEART) Recruiting NCT03278509 Phase 4 Metoprolol Succinate;Bisoprolol
19 Biventricular Alternative Pacing Withdrawn NCT00559143 Phase 4
20 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3 Benznidazole;Placebo
21 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
22 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3 Bisoprolol
23 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3 binodenoson;adenosine
24 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3 binodenoson;adenosine
25 Impact of Right Ventricular Pacing Determined by Electrocardiography Recruiting NCT01922518 Phase 3
26 Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope Recruiting NCT01814228 Phase 3
27 Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler Unknown status NCT01593644 Phase 2 adenosine + dipyridamole
28 Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker Completed NCT01945606 Phase 2 Placebo (treatment 1);BAY1067197 (treatment 2)
29 Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction Completed NCT02753478 Phase 1, Phase 2
30 SB-705498 Dental Pain Study After Tooth Extraction Completed NCT00281684 Phase 2 SB705498 400 mg;SB705498 1000 mg;Placebo;Co-Codamol
31 Second Study on Cardio-neuromodulation in Humans Recruiting NCT02954666 Phase 2
32 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Recruiting NCT02909712 Phase 2 sulfadoxine-pyrimethamine (SP);dihydroartemisinin-piperaquine (DHA-PQP)
33 Efficacy, Safety and Tolerability of BAF312 Compared to Placebo in Patients With Intracerebral Hemorrhage (ICH) Not yet recruiting NCT03338998 Phase 2 BAF312;Placebo
34 Analysis of Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart Completed NCT02462941 Phase 1 Adenosine
35 Micra Atrial Tracking Using a Ventricular Accelerometer Study Recruiting NCT03157297 Phase 1
36 Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block Unknown status NCT01477658
37 Minimizing Ventricular Pacing Unknown status NCT01611389
38 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
39 Systemic Lupus Erythematous and Heart Conduction Disorders Unknown status NCT02162992
40 Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia Unknown status NCT01310907
41 HV Electrophysiology Study In Transcatheter Aortic Valve Implantation Patients Unknown status NCT02659137
42 Safety of Early Discharge Following Low Risk Myocardial Infarction Unknown status NCT01868256
43 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
44 Observation of ImageReady™ MR Conditional Pacing System in China Unknown status NCT02636712
45 Biventricular Versus Right Ventricular Pacing in Heart Failure Patients With Atrioventricular Block (BLOCK HF) Completed NCT00267098
46 Biopace Study: Biventricular Pacing for Atrioventricular Block to Prevent Cardiac Desynchronization Completed NCT00187278
47 Pacing in First-degree AV-block Completed NCT01985802
48 Natural Evolution of AV Conduction Disorders in Patients Implanted With Cardiac Pacemakers Completed NCT00531037
49 Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode Completed NCT02586480
50 Electrophysiologic HV-interval as a Predicor for Permanent Pacemaker Implantation After TAVI Completed NCT01801098

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

# Genetic test Affiliating Genes
1 Atrioventricular Block 28

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

38
Heart, Atrioventricular Node, Kidney, Testes, Brain, B Cells, Lung

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 392)
# Title Authors Year
1
Prediction of Delayed Atrioventricular Block and Pacemaker Implantation After Transcatheter Aortic Valve Replacement With CoreValve. ( 29223288 )
2018
2
An extremely rare clinical entity: congenitally corrected transposition with situs A+nversus and single coronary artery presented with complete atrioventricular block in a young man. ( 29428001 )
2018
3
Wide QRS complex tachycardia followed by 2:1 atrioventricular block: What is the mechanism? ( 29328513 )
2018
4
Recovery of High Degree Atrioventricular Block in a Patient with Cardiac Sarcoidosis by Corticosteroid Therapy. ( 29399570 )
2018
5
Marked First-Degree Atrioventricular Block and Pseudo-Pacemaker Syndrome in a Pediatric Patient. ( 29435607 )
2018
6
Major determinant of the occurrence of pacing-induced cardiomyopathy in complete atrioventricular block: a multicentre, retrospective analysis over a 15-year period in South Korea. ( 29439074 )
2018
7
An unusual case of complete atrioventricular block causing Takotsubo syndrome. ( 29325979 )
2018
8
Prolonged PR Interval at Birth Predicting the High Occurrence of Fatal Atrioventricular Block in Hypoplastic Left Heart Syndrome. ( 29350247 )
2018
9
Interventricular septum involvement with complete atrioventricular block as first manifestation in Takayasu arteritis. ( 29340988 )
2018
10
Acute Idiopathic Gastric Distension Causing Atrioventricular Block and Cardiogenic Shock. ( 28602457 )
2017
11
A proposal of clinical ECG index "vagal score" for determining the mechanism of paroxysmal atrioventricular block. ( 28607616 )
2017
12
Cardiac resynchronization therapy via transvenous approach in a 2-year-old boy with a complete atrioventricular block after a tetralogy of Fallot repair. ( 29255519 )
2017
13
Frequency of Recovery from Complete Atrioventricular Block After Cardiac Surgery. ( 28864321 )
2017
14
Complex phenotype linked to a mutation in exon 11 of the lamin A/C gene: Hypertrophic cardiomyopathy, atrioventricular block, severe dyslipidemia and diabetes. ( 28874324 )
2017
15
Sinus node dysfunction masquerading as complete atrioventricular block in the setting of atrial parasystole after heart transplantation. ( 29263012 )
2017
16
Paroxysmal atrioventricular block: Electrophysiological mechanism of phase 4 conduction block in the His-Purkinje system: A comparison with phase 3 block. ( 28846146 )
2017
17
Hypopituitarism and hypothyroidism following atrioventricular block during nivolumab treatment. ( 28295551 )
2017
18
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
19
Masquerading bundle branch block as a presenting manifestation of complete atrioventricular block that caused syncope. ( 28627977 )
2017
20
A supraventricular tachycardia with atrioventricular block in a patient with a previous anteroseptal myocardial infarction. ( 29195549 )
2017
21
A second-degree atrioventricular block with double escape rhythm secondary to paroxysmal vagal hypertonia. ( 28857928 )
2017
22
Prevalence and spectrum of NKX2.5 mutations in patients with congenital atrial septal defect and atrioventricular block. ( 28259982 )
2017
23
Third-Degree Atrioventricular Block and Collapse Associated with Eosinophilic Myocarditis in a Horse. ( 28295606 )
2017
24
Hisian extrasystole mimicking second degree atrioventricular block. a case report. ( 29424877 )
2017
25
Atrioventricular block masked by posteroseptal bypass tract located in coronary sinus aneurysm. ( 28821328 )
2017
26
Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis. ( 29424197 )
2017
27
Syncope and paroxysmal atrioventricular block. ( 29255501 )
2017
28
Marked Symptomatic Sinus Bradycardia With New Onset First-Degree Atrioventricular Block After Concomitant Methadone and Trazodone Use. ( 28953513 )
2017
29
Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant. ( 28638671 )
2017
30
Swallow presyncope in an athletic patient caused by third-degree atrioventricular block. ( 29202647 )
2017
31
Atrioventricular block after reperfusion: A reflection on early beta-blocker therapy for acute myocardial infarction. ( 29256884 )
2017
32
Syncope, Junctional Premature Complexes, and Pseudo-Type II Atrioventricular Block. ( 29395000 )
2017
33
Atrioventricular block due to papillary fibroelastoma. ( 28942946 )
2017
34
Transient sick sinus syndrome with complete atrioventricular block associated with ergonovine intake: A case report. ( 29095320 )
2017
35
The use of non-invasive fetal electrocardiography in diagnosing second-degree fetal atrioventricular block. ( 28794892 )
2017
36
Third-degree atrioventricular block: tip of the iceberg of a systemic disease. ( 28204445 )
2017
37
Catheter ablation as a treatment of atrioventricular block. ( 28823599 )
2017
38
Missed aortic valve endocarditis resulting in complete atrioventricular block and redo mechanical valve replacement. ( 28775090 )
2017
39
Successful prenatal management of ventricular tachycardia and second-degree atrioventricular block in fetal long QT syndrome. ( 28491768 )
2017
40
Congenital complete atrioventricular block with pulmonary hypertension. ( 28809080 )
2017
41
Symptomatic first-degree atrioventricular block in a young woman after taking a fat burner supplement. ( 29162998 )
2017
42
Maternal steroid therapy for fetuses with immune-mediated complete atrioventricular block: a systematic review and meta-analysis. ( 29251180 )
2017
43
Genetic Mechanisms Contribute to the Development of Heart Failure in Patients with Atrioventricular Block and Right Ventricular Apical Pacing. ( 28878402 )
2017
44
Complete atrioventricular block in acute coronary syndrome: prevalence, characterisation and implication on outcome. ( 28617040 )
2017
45
Vagal third-degree atrioventricular block in a highly trained endurance athlete. ( 28430941 )
2017
46
Coronary Slow Flow Phenomenon and Atrioventricular Block: A Case Report. ( 28828024 )
2017
47
Heparan sulfate storage in the cardiac conduction system triggers atrioventricular block. ( 28089344 )
2017
48
Perservative paroxysmal atrioventricular block : Cardiac syncope misdiagnosed as anxiety for more than 20A years. ( 28840364 )
2017
49
Mobitz Type II Atrioventricular Block following Tramadol and Fentanyl in a Patient with Acute Coronary Syndrome and Systolic Heart Failure. ( 29184615 )
2017
50
A novel desmin (DES) indel mutation causes severe atypical cardiomyopathy in combination with atrioventricular block and skeletal myopathy. ( 29274115 )
2017

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.52 KCNE1 KCNQ1 SCN5A TRPM4
2
Show member pathways
12.29 GATA4 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5
3
Show member pathways
12.22 GATA4 NKX2-5 NPPB TBX5
4 12.11 KCNE1 KCNE2 KCNH2 KCNQ1
5
Show member pathways
11.99 GATA4 NKX2-5 TBX5
6 11.92 KCNH2 KCNQ1 SCN5A
7
Show member pathways
11.87 HCN4 KCNH2 KCNQ1
8 11.81 GATA4 NKX2-5 TBX5
9 11.65 GATA4 NKX2-5 TBX5
10
Show member pathways
11.43 KCNE1 KCNE2 KCNQ1 SCN5A
11 11.24 GATA4 NKX2-5 TBX5
12 11.18 GATA4 NKX2-5 SCN5A TBX5
13 10.92 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 LMNA
14 10.89 GATA4 NKX2-5 NPPB
15 10.78 HCN4 KCNE1 KCNQ1
16 10.21 GATA4 NKX2-5

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.55 CRYAB KCNE1 KCNE2 KCNH2 SCN5A
2 Z disc GO:0030018 9.43 CRYAB KCNE1 SCN5A
3 macromolecular complex GO:0032991 8.96 NKX2-5 TBX5
4 voltage-gated potassium channel complex GO:0008076 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 49)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.93 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
2 potassium ion transport GO:0006813 9.92 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
3 potassium ion transmembrane transport GO:0071805 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
4 regulation of membrane potential GO:0042391 9.85 HCN4 KCNH2 TRPM4
5 cellular response to drug GO:0035690 9.83 KCNE2 KCNH2 KCNQ1
6 cellular response to cAMP GO:0071320 9.8 HCN4 KCNE1 KCNQ1
7 cardiac muscle contraction GO:0060048 9.8 KCNH2 KCNQ1 NKX2-5 SCN5A
8 cardiac muscle cell differentiation GO:0055007 9.77 GATA4 NKX2-5 TBX5
9 cardiac muscle cell action potential involved in contraction GO:0086002 9.77 KCNE1 KCNE2 SCN5A
10 regulation of potassium ion transmembrane transport GO:1901379 9.76 KCNE1 KCNE2 KCNH2
11 positive regulation of potassium ion transmembrane transport GO:1901381 9.75 KCNE1 KCNH2 KCNQ1
12 atrial septum morphogenesis GO:0060413 9.74 GATA4 NKX2-5 TBX5
13 membrane repolarization GO:0086009 9.73 KCNE1 KCNE2 KCNH2 KCNQ1
14 regulation of membrane repolarization GO:0060306 9.72 KCNE2 KCNH2 KCNQ1
15 ventricular septum development GO:0003281 9.71 GATA4 TBX5
16 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.71 KCNE1 KCNH2 KCNQ1
17 potassium ion export GO:0071435 9.71 KCNE1 KCNE2 KCNH2 KCNQ1
18 membrane depolarization during action potential GO:0086010 9.7 KCNH2 SCN5A
19 regulation of cardiac muscle contraction GO:0055117 9.7 HCN4 NKX2-5
20 positive regulation of heart rate GO:0010460 9.7 KCNQ1 TRPM4
21 positive regulation of sodium ion transport GO:0010765 9.7 NKX2-5 SCN5A
22 cardiovascular system development GO:0072358 9.69 KCNQ1 NKX2-5
23 sodium ion import across plasma membrane GO:0098719 9.69 HCN4 TRPM4
24 endocardial cushion development GO:0003197 9.68 GATA4 TBX5
25 regulation of cardiac muscle cell contraction GO:0086004 9.68 GATA4 SCN5A
26 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.68 HCN4 SCN5A
27 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.67 KCNE1 KCNE2
28 ventricular cardiac muscle cell development GO:0055015 9.67 LMNA NKX2-5
29 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNE2 KCNH2 KCNQ1
30 cardiac ventricle morphogenesis GO:0003208 9.66 GATA4 NKX2-5
31 atrial cardiac muscle cell action potential GO:0086014 9.66 KCNQ1 SCN5A
32 regulation of delayed rectifier potassium channel activity GO:1902259 9.65 KCNE1 KCNE2
33 SA node cell action potential GO:0086015 9.65 HCN4 SCN5A
34 positive regulation of cardioblast differentiation GO:0051891 9.65 GATA4 NKX2-5 TBX5
35 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
36 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.64 KCNQ1 SCN5A
37 membrane depolarization during SA node cell action potential GO:0086046 9.64 HCN4 SCN5A
38 membrane depolarization during AV node cell action potential GO:0086045 9.63 SCN5A TRPM4
39 cardiac conduction GO:0061337 9.63 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A TRPM4
40 potassium ion export across plasma membrane GO:0097623 9.62 KCNH2 KCNQ1
41 bundle of His development GO:0003166 9.62 NKX2-5 TBX5
42 membrane repolarization during action potential GO:0086011 9.62 KCNE1 KCNE2 KCNH2 KCNQ1
43 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.61 SCN5A TRPM4
44 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 SCN5A TRPM4
45 ventricular cardiac muscle cell action potential GO:0086005 9.35 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
46 regulation of heart rate by cardiac conduction GO:0086091 9.17 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
47 transport GO:0006810 10.23 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
48 ion transport GO:0006811 10.1 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
49 transmembrane transport GO:0055085 10.08 HCN4 KCNH2 KCNQ1 SCN5A TRPM4

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.77 HCN4 KCNE2 KCNH2 KCNQ1 SCN5A
2 ion channel activity GO:0005216 9.73 HCN4 KCNH2 SCN5A TRPM4
3 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0001228 9.7 GATA4 NKX2-5 TBX5
4 ion channel binding GO:0044325 9.65 KCNE2 KCNQ1 SCN5A
5 potassium channel activity GO:0005267 9.65 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
6 scaffold protein binding GO:0097110 9.63 KCNH2 KCNQ1 SCN5A
7 sodium channel activity GO:0005272 9.58 HCN4 SCN5A TRPM4
8 voltage-gated potassium channel activity GO:0005249 9.55 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
9 voltage-gated sodium channel activity GO:0005248 9.51 HCN4 SCN5A
10 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.5 KCNE1 KCNH2 KCNQ1
11 inward rectifier potassium channel activity GO:0005242 9.49 KCNE2 KCNH2
12 delayed rectifier potassium channel activity GO:0005251 9.26 KCNE1 KCNE2 KCNH2 KCNQ1
13 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Sources for Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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