MCID: ATR057
MIFTS: 49

Atrioventricular Block malady

Categories: Cardiovascular diseases

Aliases & Classifications for Atrioventricular Block

Aliases & Descriptions for Atrioventricular Block:

Name: Atrioventricular Block 12 29 52 42 14 69
Av Block 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0050820
ICD10 33 I44.3 I44.30
ICD9CM 35 426.10
MeSH 42 D054537
NCIt 47 C26703
UMLS 69 C0004245

Summaries for Atrioventricular Block

Disease Ontology : 12 A heart conduction disease that is characterized by the impairment of the conduction between the atria and ventricles of the heart.

MalaCards based summary : Atrioventricular Block, also known as av block, is related to third-degree atrioventricular block and second-degree atrioventricular block. An important gene associated with Atrioventricular Block is SCN5A (Sodium Voltage-Gated Channel Alpha Subunit 5), and among its related pathways/superpathways are Vascular smooth muscle contraction and Cardiac conduction. The drugs Enfuvirtide and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include heart, testes and brain, and related phenotypes are cardiovascular system and muscle

Wikipedia : 71 Atrioventricular block (AV block) is a type of heart block in which the conduction between the atria and... more...

Related Diseases for Atrioventricular Block

Diseases related to Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 157)
id Related Disease Score Top Affiliating Genes
1 third-degree atrioventricular block 31.2 CRYAB GATA4 HCN4 KCNE1 KCNE2 KCNH2
2 second-degree atrioventricular block 12.5
3 first-degree atrioventricular block 12.5
4 mobitz type ii atrioventricular block 12.2
5 heart block, congenital 11.5
6 heart block, progressive, type ia 10.9
7 myocardial infarction 10.3
8 micturation-induced seizures 10.3 HCN4 SCN5A
9 endocardium disease 10.2 HCN4 LMNA
10 cardiomyopathy 10.2
11 myocarditis 10.2
12 lipodystrophy, familial partial, type 5 10.2 HCN4 SCN5A
13 proximal renal tubular acidosis 10.2 KCNH2 KCNQ1
14 syncope 10.2
15 inferior myocardial infarction 10.2
16 cardiac sarcoidosis 10.2
17 sick sinus syndrome 10.2
18 migraine with aura 9 10.2 KCNH2 KCNQ1 SCN5A
19 atrial fibrillation 10.1
20 spastic paraplegia 29, autosomal dominant 10.1 KCNH2 KCNQ1
21 familial sick sinus syndrome 10.1 KCNH2 KCNQ1 SCN5A
22 pervasive developmental disorder 10.1 KCNH2 LMNA NPPB
23 long qt syndrome 10.1
24 acute myocarditis 10.1
25 emery-dreifuss muscular dystrophy 7, ad 10.1 NKX2-5 SCN5A
26 cerebral creatine deficiency syndrome 10.1 KCNE1 KCNH2 KCNQ1
27 pollen allergy 10.1 HCN4 KCNQ1 LMNA SCN5A
28 autosomal dominant nocturnal frontal lobe epilepsy 2 10.0 KCNE2 KCNH2 KCNQ1 SCN5A
29 macroglossia 10.0 GATA4 NKX2-5 NPPB
30 fanconi anemia complementation group r 10.0 SCN5A TRPM4
31 tardbp-related frontotemporal dementia 10.0 KCNE1 KCNH2 KCNQ1 SCN5A
32 right bundle branch block 10.0
33 tricuspid valve disease 10.0 HCN4 KCNE2 NPPB TRIM21
34 dilated cardiomyopathy 10.0
35 endocarditis 10.0
36 myopathy 10.0
37 uterine fibroid 10.0 HCN4 SCN5A TRPM4
38 retinal cone dystrophy 4 10.0 KCNE1 KCNQ1
39 restrictive cardiomyopathy 9.9
40 ventricular septal defect 9.9
41 kearns-sayre syndrome 9.9
42 fatal infantile encephalomyopathy 9.9 NKX2-5 SCN5A TRPM4
43 combined oxidative phosphorylation deficiency 17 9.9 NKX2-5 SCN5A TRPM4
44 multicentric carpotarsal osteolysis syndrome 9.9 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
45 vulvar sebaceous carcinoma 9.9 GATA4 TBX5
46 brugada syndrome 1 9.9 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
47 cdkl5-related angelman-like syndrome 9.9 CRYAB LMNA NPPB SCN5A
48 isolated encephalocele 9.9 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
49 keppen-lubinsky syndrome 9.9 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
50 parkinson disease 20, early-onset 9.9 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A

Comorbidity relations with Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 15)


Acute Cystitis Chronic Myocardial Ischemia
Deficiency Anemia Familial Atrial Fibrillation
First-Degree Atrioventricular Block Heart Disease
Hypertension, Essential Intermediate Coronary Syndrome
Ischemic Heart Disease Left Ventricular Outflow Tract Obstruction
Mitral Valve Disease Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia

Graphical network of the top 20 diseases related to Atrioventricular Block:



Diseases related to Atrioventricular Block

Symptoms & Phenotypes for Atrioventricular Block

MGI Mouse Phenotypes related to Atrioventricular Block:

44
id Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.81 GATA4 HCN4 KCNH2 KCNQ1 LMNA NKX2-5
2 muscle MP:0005369 9.61 NKX2-5 SCN5A TBX5 CRYAB GATA4 HCN4
3 normal MP:0002873 9.17 GATA4 HCN4 KCNQ1 LMNA NKX2-5 SCN5A

Drugs & Therapeutics for Atrioventricular Block

Drugs for Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 111)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Enfuvirtide Approved, Investigational Phase 4 159519-65-0 16130199
2
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
3
Heparin Approved, Investigational Phase 4 9005-49-6 772 46507594
4
Nicorandil Approved Phase 4 65141-46-0 47528
5
Ticagrelor Approved Phase 4 274693-27-5 9871419
6
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
7
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
8
Levofloxacin Approved, Investigational Phase 4 100986-85-4 149096
9
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
10
Norgestimate Approved Phase 4 35189-28-7 6540478
11
Ofloxacin Approved Phase 4 82419-36-1 4583
12
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
13
Diltiazem Approved Phase 4 42399-41-7 39186
14
Bisoprolol Approved Phase 4,Phase 3 66722-44-9 2405
15
Amiloride Approved Phase 4 2016-88-8, 2609-46-3 16231
16
Furosemide Approved, Vet_approved Phase 4 54-31-9 3440
17
Ramipril Approved Phase 4 87333-19-5 5362129
18
Spironolactone Approved Phase 4 1952-01-7, 52-01-7 5833
19
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
20
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2 59-30-3 6037
21 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1
22 Antihypertensive Agents Phase 4,Phase 3
23 calcium heparin Phase 4
24 Micronutrients Phase 4
25 Platelet Aggregation Inhibitors Phase 4,Phase 2
26 Trace Elements Phase 4
27 Vasodilator Agents Phase 4,Phase 3,Phase 2,Phase 1
28 Vitamin B Complex Phase 4,Phase 2
29 Vitamins Phase 4
30 Anti-Infective Agents Phase 4,Phase 3,Phase 2
31 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
32 Peripheral Nervous System Agents Phase 4,Phase 3,Phase 2,Phase 1
33 Anti-Bacterial Agents Phase 4
34 Contraceptive Agents Phase 4
35 Contraceptives, Oral Phase 4
36 Contraceptives, Oral, Combined Phase 4
37 Cytochrome P-450 CYP1A2 Inhibitors Phase 4
38 Cytochrome P-450 Enzyme Inhibitors Phase 4
39 Estradiol 17 beta-cypionate Phase 4
40 Estradiol 3-benzoate Phase 4
41 Estradiol valerate Phase 4 979-32-8
42 Norgestimate, ethinyl estradiol drug combination Phase 4
43 Polyestradiol phosphate Phase 4
44 Renal Agents Phase 4,Phase 2
45 Topoisomerase Inhibitors Phase 4
46 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2
47 Adrenergic Agents Phase 4,Phase 3
48 Adrenergic Antagonists Phase 4,Phase 3
49 Adrenergic beta-1 Receptor Antagonists Phase 4,Phase 3
50 Autonomic Agents Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 113)
id Name Status NCT ID Phase
1 Right Ventricular Septal Pacing for the Prevention of Left Ventricular Dysfunction in Patients With Atrio-Ventricular Block Unknown status NCT00709774 Phase 4
2 Ventricular Pacing Site Selection (V-PASS) Unknown status NCT00292383 Phase 4
3 Safety and the Effects of Isolated Left Ventricular Pacing in Patients With Bradyarrhythmias Unknown status NCT01717469 Phase 4
4 Efficacy of a Pacemaker Algorithm in Promotion of the Intrinsic Heart Activity. Unknown status NCT00156741 Phase 4
5 Effect of Nicorandil for the Patients of Acute ST Segment Elevation Myocardial Infarction Unknown status NCT02435797 Phase 4
6 Mode Evaluation in Sick Sinus Syndrome Trial (MODEST) Unknown status NCT00161551 Phase 4
7 Acute and Chronic Effect of His-pacing in Consecutive Patients With AV-block Completed NCT01019213 Phase 4
8 CryoCath Freezor CryoAblation Catheter System (CRYOFACTS) Completed NCT00621621 Phase 4
9 Spontaneous Atrio Ventricular Conduction Preservation Completed NCT00655213 Phase 4
10 Evaluation of the SafeR Mode in Patients With a Dual Chamber Pacemaker Indication Completed NCT00562107 Phase 4
11 Magnetically Navigated vs. Manually Guided Radiofrequency in Atrioventricular-node-reentry-tachycardia Completed NCT00875914 Phase 4
12 Avelox for Treatment of Elderly Patients With Community Acquired Pneumonia Completed NCT00665327 Phase 4
13 Beluga - Clinical Observations of Automatic Algorithms for Cardiac Pacing Completed NCT00286858 Phase 4
14 Prevention of Atrial Arrhythmia in Patients Without Atrioventricular (AV) Conduction Disease Completed NCT01170611 Phase 4
15 Study of Ablation Versus antiaRrhythmic Drugs in Persistent Atrial Fibrillation Completed NCT00863213 Phase 4
16 MINERVA: MINimizE Right Ventricular Pacing to Prevent Atrial Fibrillation and Heart Failure Completed NCT00262119 Phase 4
17 Comparative Study Between Cryoablation and Radiofrequency Ablation in the Treatment of Supraventricular Tachycardia Recruiting NCT01584154 Phase 4
18 Assessment of the Prognosis of Persistent Left Bundle Branch Block (LBBB)After Transcatheter Aortic Valve Implantation (TAVI ) by an Electrophysiological and Remote Monitoring Risk-adapted Algorithm Recruiting NCT02482844 Phase 4
19 Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Recruiting NCT02832973 Phase 4
20 Safety and Effectiveness of Drug up Titration by Nurses Specialized in Heart Failure (HF) Patients Recruiting NCT02546856 Phase 4
21 Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial. Active, not recruiting NCT01311700 Phase 4
22 Atrial Fibrillation Ablation Compared to Rate Control Strategy in Patients With Impaired Left Ventricular Function Not yet recruiting NCT02509754 Phase 4
23 Biventricular Alternative Pacing Withdrawn NCT00559143 Phase 4
24 BENEFIT: Evaluation of the Use of Antiparasital Drug (Benznidazole) in the Treatment of Chronic Chagas' Disease Unknown status NCT00123916 Phase 3
25 RAMYD Study - Evaluation of Arrhythmic Risk in Myotonic Dystrophy Unknown status NCT00127582 Phase 3
26 Comparison of SEPTal and Apical Pacing Sites in PerManent Right Ventricular Pacing Completed NCT00925691 Phase 3
27 Chagas Cardiomyopathy Bisoprolol Intervention Study: Charity Completed NCT00323973 Phase 3
28 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944970 Phase 3
29 Efficacy and Safety Study of Binodenoson in Assessing Cardiac Ischemia Completed NCT00944294 Phase 3
30 Comparison of AAIsafeR and DDD Modes in Non-selected Patients Completed NCT01219621 Phase 3
31 Impact of Right Ventricular Pacing Determined by Electrocardiography Recruiting NCT01922518 Phase 3
32 Efficacy of Transcatheter Ablation Using Anatomic Approach of Ganglionated Plexi Located in the Right Atrium to Prevent Neuromediated Cardioinhibitory Syncope Recruiting NCT01814228 Phase 3
33 The Danish Multicenter Randomised Study on AAI Versus DDD Pacing in Sick Sinus Syndrome Terminated NCT00236158 Phase 2, Phase 3
34 Phase II Study for the Diagnosis and Functional Assessment of CAD Using Transthoracic-Echodoppler Unknown status NCT01593644 Phase 2
35 Study to Assess the Safety of BAY1067197 in Stable Heart Failure Patients on Standard Therapy Including ß-blocker Completed NCT01945606 Phase 2
36 Safety and Feasibility of Intracoronary Hypothermia in Acute Myocardial Infarction Completed NCT02753478 Phase 1, Phase 2
37 Intravenous L-Citrulline to Treat Children Undergoing Heart Bypass Surgery : Revised Protocol Completed NCT01120964 Phase 1, Phase 2
38 Multiple Dose Study in Heart Failure of BAY 1067197 Completed NCT02040233 Phase 2
39 Second Study on Cardio-neuromodulation in Humans Recruiting NCT02954666 Phase 2
40 Cardio‑Safety of Dihydroartemisinin‑Piperaquine and Pharmacokinetics of Piperaquine Amongst Pregnant Women in Tanzania Recruiting NCT02909712 Phase 2
41 Analysis of Adenosine on Sinus and Atrioventricular Nodal Conduction in the Pediatric Transplanted Heart Active, not recruiting NCT02462941 Phase 1
42 Micra Atrial Tracking Using a Ventricular Accelerometer Study Not yet recruiting NCT03157297 Phase 1
43 Effects of Chronic Right Ventricular Pacing in Children With Advanced Atrioventricular Block Unknown status NCT01477658
44 Minimizing Ventricular Pacing Unknown status NCT01611389
45 Left Ventricular Function and Remodelling During Permanent Pacing Unknown status NCT00228241
46 Identify the Genes Polymorphisms Related to Non-familial Bradyarrhythmia Unknown status NCT01310907
47 Safety of Early Discharge Following Low Risk Myocardial Infarction Unknown status NCT01868256
48 RV Septal Versus Minimized RV Pacing in Sick Sinus Syndrome Unknown status NCT01477138
49 Choosing the Right Pacing Mode in Heart Failure - The CHOICE Trial Unknown status NCT00875732
50 Biospecimen Repository for Cardiac Arrhythmias at the Cleveland Clinic Unknown status NCT00921986

Search NIH Clinical Center for Atrioventricular Block

Cochrane evidence based reviews: atrioventricular block

Genetic Tests for Atrioventricular Block

Genetic tests related to Atrioventricular Block:

id Genetic test Affiliating Genes
1 Atrioventricular Block 29

Anatomical Context for Atrioventricular Block

MalaCards organs/tissues related to Atrioventricular Block:

39
Heart, Testes, Brain, Lung, B Cells, Retina, Tonsil

Publications for Atrioventricular Block

Articles related to Atrioventricular Block:

(show top 50) (show all 339)
id Title Authors Year
1
Heparan sulfate storage in the cardiac conduction system triggers atrioventricular block. ( 28089344 )
2017
2
Computed tomography is important in appropriately diagnosing patients with third-degree atrioventricular block and second-degree atrioventricular block but not Wenckebach type. ( 27886613 )
2017
3
Prevalence of Left Ventricular Dyssynchrony in Patients with Congenital Atrioventricular Block and Long-Term Pacing: A Three-Dimensional Echocardiography Study. ( 27145970 )
2016
4
Symptomatic exercise-induced complete atrioventricular block due to severe superior vena cava stenosis. ( 27116327 )
2016
5
A rare cause of aortic regurgitation and complete atrioventricular block. ( 28017926 )
2016
6
Steroid Therapy Ameliorated Myocardial Fatty Acid Metabolism With Recovery of Complete Atrioventricular Block in Cardiac Sarcoidosis. ( 26973088 )
2016
7
A Novel Mechanism of Atrioventricular Block Following Transcatheter Closure ofA an Atrial Septal Defect. ( 27639905 )
2016
8
Incidence and predictors of right ventricular pacing-induced cardiomyopathy in patients with complete atrioventricular block and preserved left ventricular systolic function. ( 27855853 )
2016
9
Detection and successful treatment of emergent anti-SSA mediated fetal atrioventricular block. ( 27403848 )
2016
10
Atrial Tachycardia Originating in the Vicinity of the Non-Coronary Sinus of Valsalva: Report of a Series Including the First Case of Ablation-Related Complete Atrioventricular Block. ( 27557488 )
2016
11
Paroxysmal atrioventricular block after heart transplantation in children: an early sign of rejection? ( 27743416 )
2016
12
Olmesartan Reduces New-onset Atrial Fibrillation and Atrial Fibrillation Burden after Dual-chamber Pacemaker Implantation in Atrioventricular Block Patients. ( 27625082 )
2016
13
Differential effects of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block: a commentary. ( 27302390 )
2016
14
Right Ventricular Versus Biventricular Pacing for Heart Failure and Atrioventricular Block. ( 27553893 )
2016
15
Intermittent High-Grade Atrioventricular Block in a Man With Infective Endocarditis. ( 27087175 )
2016
16
Late Outcome and Predictors of Adverse Events Related to the Implantation of a Permanent Pacemaker in Patients with Isolated Congenital Atrioventricular Block. ( 27335082 )
2016
17
Continuous intraoperative monitoring of vagus and recurrent laryngeal nerve function in patients with advanced atrioventricular block. ( 27138019 )
2016
18
Incidence and predictors of new-onset atrioventricular block requiring pacemaker implantation after sutureless aortic valve replacement. ( 27572616 )
2016
19
A Review of Surgical Atrioventricular Block with Emphasis in Patients with Single Ventricle Physiology. ( 27139742 )
2016
20
InA vivo analysis of torsadogenic potential of an antipsychotic drug paliperidone using the acute atrioventricular block rabbit as a proarrhythmia model. ( 27262905 )
2016
21
Assessment of Safety Margin of an Antipsychotic Drug Haloperidol for Torsade de Pointes Using the Chronic Atrioventricular Block Dogs. ( 27738880 )
2016
22
Fluorinated steroids do not improve outcome of isolated atrioventricular block. ( 27728859 )
2016
23
Second-Degree Atrioventricular Block Occurring After Tooth Extraction. ( 27585419 )
2016
24
First-degree atrioventricular block: risk marker or innocent finding? ( 26936340 )
2016
25
High degree atrioventricular block with ventricular asystole in a case of dengue fever. ( 27751287 )
2016
26
Atrioventricular dissociation with QRS complex change in the atrioventricular block: What are the degree and the site of block? ( 27728867 )
2016
27
Calcified left ventricular noncompaction with complete atrioventricular block. ( 27372727 )
2016
28
Differential Clinical Implications of High-Degree Atrioventricular Block Complicating ST-Segment Elevation Myocardial Infarction according to the Location of Infarction in the Era of Primary Percutaneous Coronary Intervention. ( 27275168 )
2016
29
Syncope in patients paced for atrioventricular block. ( 26851815 )
2016
30
Beat-to-Beat Variability in Preload Unmasks Latent Risk of Torsade de Pointes in Anesthetized Chronic Atrioventricular Block Dogs. ( 27151565 )
2016
31
Complete Atrioventricular Block Complicating Mitral Infective Endocarditis Caused by Streptococcus Agalactiae. ( 27604147 )
2016
32
Reducing Ventricular Pacing Frequency in Patients With Atrioventricular Block: Is It Time to Change the Current Pacing Paradigm? ( 27637555 )
2016
33
Aortic aneurysm with complete atrioventricular block and acute coronary syndrome. ( 27142198 )
2016
34
Pacing From the Right Ventricular Septum and Development of New Atrial Fibrillation in Paced Patients With Atrioventricular Block and Preserved Left Ventricular Function. ( 27680658 )
2016
35
Diagnosed late cardiac sarcoidosis in a patient with atrioventricular block. ( 27828755 )
2016
36
Long-term outcome in patients receiving permanent pacemaker implantation for atrioventricular block: Comparison of VDD and DDD pacing. ( 27583889 )
2016
37
High Incidence of Dilated Cardiomyopathy After Right Ventricular Inlet Pacing in Patients With Congenital Complete Atrioventricular Block. ( 27008922 )
2016
38
Differential effect of ganglionic plexi ablation in a patient with neurally mediated syncope and intermittent atrioventricular block. ( 27194540 )
2016
39
Severe Hyponatremia Leading to Complete Atrioventricular Block. ( 27321971 )
2016
40
Case images: Cannon 'A' waves during complete atrioventricular block. ( 27665341 )
2016
41
New-onset third-degree atrioventricular block because of autoimmune-induced myositis under treatment with anti-programmed cell death-1 (nivolumab) for metastatic melanoma. ( 27977496 )
2016
42
Laser Doppler vibrometry as a noncontact method to detect various degrees of atrioventricular block: a feasibility study. ( 27103102 )
2016
43
TCT-199 Incidence, Predictors, and Outcomes of High-Grade Atrioventricular Block in Patients With STEMI Undergoing Primary PCI: The HORIZONS-AMI Trial. ( 27970372 )
2016
44
Variants of Transient Receptor Potential Melastatin Member 4 in Childhood Atrioventricular Block. ( 27207958 )
2016
45
Transient severe tricuspid regurgitation during atrioventricular block. ( 26961549 )
2016
46
Atrioventricular block after ASD closure. ( 27540418 )
2016
47
Dilated Cardiomyopathy in Children With Isolated Congenital Complete Atrioventricular Block. ( 27053494 )
2016
48
A premature low-birth-weight infant with congenital complete atrioventricular block and myocarditis successfully treated by staged pacemaker implantation. ( 27071550 )
2016
49
A 1-year-old boy with long pauses caused by paroxysmal atrioventricular block and sinus arrest: Vagal reflex and effect of pacing. ( 27836167 )
2016
50
A case of gingival cancer with pulmonary metastases that developed complete atrioventricular block and ventricular fibrillation as a result of myocardial metastases. ( 27980736 )
2016

Variations for Atrioventricular Block

ClinVar genetic disease variations for Atrioventricular Block:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 SCN5A NM_198056.2(SCN5A): c.4783G> A (p.Asp1595Asn) single nucleotide variant Pathogenic/Likely pathogenic rs137854607 GRCh37 Chromosome 3, 38595800: 38595800

Expression for Atrioventricular Block

Search GEO for disease gene expression data for Atrioventricular Block.

Pathways for Atrioventricular Block

Pathways related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 16)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
12.64 GATA4 KCNE1 KCNQ1 NPPB SCN5A
2
Show member pathways
12.29 GATA4 KCNE1 KCNE2 KCNH2 KCNQ1 NKX2-5
3
Show member pathways
12.24 GATA4 NKX2-5 NPPB TBX5
4 12.11 KCNE1 KCNE2 KCNH2 KCNQ1
5
Show member pathways
11.99 GATA4 NKX2-5 TBX5
6 11.94 KCNH2 KCNQ1 SCN5A
7
Show member pathways
11.88 HCN4 KCNH2 KCNQ1
8 11.83 GATA4 NKX2-5 TBX5
9 11.67 GATA4 NKX2-5 TBX5
10
Show member pathways
11.43 KCNE1 KCNE2 KCNQ1 SCN5A
11 11.24 GATA4 NKX2-5 TBX5
12 11.18 GATA4 NKX2-5 SCN5A TBX5
13 10.92 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 LMNA
14 10.89 GATA4 NKX2-5 NPPB
15 10.78 HCN4 KCNE1 KCNQ1
16 10.21 GATA4 NKX2-5

GO Terms for Atrioventricular Block

Cellular components related to Atrioventricular Block according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.35 CRYAB KCNE1 KCNE2 KCNH2 SCN5A
2 Z disc GO:0030018 9.33 CRYAB KCNE1 SCN5A
3 voltage-gated potassium channel complex GO:0008076 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Biological processes related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 50)
id Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.98 KCNH2 KCNQ1 SCN5A TRPM4
2 regulation of ion transmembrane transport GO:0034765 9.91 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
3 potassium ion transport GO:0006813 9.89 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
4 potassium ion transmembrane transport GO:0071805 9.88 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
5 regulation of membrane potential GO:0042391 9.85 HCN4 KCNH2 TRPM4
6 cellular response to drug GO:0035690 9.83 KCNE2 KCNH2 KCNQ1
7 cardiac muscle contraction GO:0060048 9.81 KCNH2 KCNQ1 NKX2-5 SCN5A
8 cellular response to cAMP GO:0071320 9.8 HCN4 KCNE1 KCNQ1
9 cardiac muscle cell differentiation GO:0055007 9.77 GATA4 NKX2-5 TBX5
10 cardiac muscle cell action potential involved in contraction GO:0086002 9.77 KCNE1 KCNE2 SCN5A
11 regulation of potassium ion transmembrane transport GO:1901379 9.76 KCNE1 KCNE2 KCNH2
12 positive regulation of potassium ion transmembrane transport GO:1901381 9.75 KCNE1 KCNH2 KCNQ1
13 atrial septum morphogenesis GO:0060413 9.74 GATA4 NKX2-5 TBX5
14 regulation of membrane repolarization GO:0060306 9.72 KCNE2 KCNH2 KCNQ1
15 ventricular septum development GO:0003281 9.71 GATA4 TBX5
16 membrane depolarization during action potential GO:0086010 9.71 KCNH2 SCN5A
17 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.71 KCNE1 KCNH2 KCNQ1
18 potassium ion export GO:0071435 9.71 KCNE1 KCNE2 KCNH2 KCNQ1
19 regulation of cardiac muscle contraction GO:0055117 9.7 HCN4 NKX2-5
20 positive regulation of heart rate GO:0010460 9.7 KCNQ1 TRPM4
21 positive regulation of sodium ion transport GO:0010765 9.7 NKX2-5 SCN5A
22 membrane repolarization GO:0086009 9.7 KCNE1 KCNE2 KCNQ1
23 sodium ion import across plasma membrane GO:0098719 9.69 HCN4 TRPM4
24 cardiovascular system development GO:0072358 9.69 KCNQ1 NKX2-5
25 regulation of cardiac muscle cell contraction GO:0086004 9.69 GATA4 SCN5A
26 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.68 HCN4 SCN5A
27 endocardial cushion development GO:0003197 9.68 GATA4 TBX5
28 ventricular cardiac muscle cell development GO:0055015 9.68 LMNA NKX2-5
29 cardiac ventricle morphogenesis GO:0003208 9.67 GATA4 NKX2-5
30 membrane repolarization during ventricular cardiac muscle cell action potential GO:0098915 9.67 KCNE1 KCNE2 KCNH2 KCNQ1
31 atrial cardiac muscle cell action potential GO:0086014 9.66 KCNQ1 SCN5A
32 negative regulation of delayed rectifier potassium channel activity GO:1902260 9.65 KCNE1 KCNE2
33 regulation of delayed rectifier potassium channel activity GO:1902259 9.65 KCNE1 KCNE2
34 SA node cell action potential GO:0086015 9.65 HCN4 SCN5A
35 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.65 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
36 regulation of atrial cardiac muscle cell membrane repolarization GO:0060372 9.64 KCNQ1 SCN5A
37 membrane depolarization during SA node cell action potential GO:0086046 9.64 HCN4 SCN5A
38 membrane depolarization during AV node cell action potential GO:0086045 9.63 SCN5A TRPM4
39 positive regulation of cardioblast differentiation GO:0051891 9.63 GATA4 NKX2-5 TBX5
40 potassium ion export across plasma membrane GO:0097623 9.62 KCNH2 KCNQ1
41 bundle of His development GO:0003166 9.62 NKX2-5 TBX5
42 membrane repolarization during action potential GO:0086011 9.62 KCNE1 KCNE2 KCNH2 KCNQ1
43 membrane depolarization during Purkinje myocyte cell action potential GO:0086047 9.61 SCN5A TRPM4
44 membrane depolarization during bundle of His cell action potential GO:0086048 9.61 SCN5A TRPM4
45 ventricular cardiac muscle cell action potential GO:0086005 9.55 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
46 cardiac conduction GO:0061337 9.43 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A TRPM4
47 regulation of heart rate by cardiac conduction GO:0086091 9.17 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
48 transport GO:0006810 10.24 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
49 ion transport GO:0006811 10.1 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1 SCN5A
50 transmembrane transport GO:0055085 10.06 HCN4 KCNH2 KCNQ1 SCN5A TRPM4

Molecular functions related to Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 14)
id Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.77 HCN4 KCNE2 KCNH2 KCNQ1 SCN5A
2 calmodulin binding GO:0005516 9.71 KCNQ1 SCN5A TRPM4
3 ion channel activity GO:0005216 9.71 HCN4 KCNH2 SCN5A TRPM4
4 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0001228 9.67 GATA4 NKX2-5 TBX5
5 ion channel binding GO:0044325 9.65 KCNE2 KCNQ1 SCN5A
6 potassium channel activity GO:0005267 9.65 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
7 scaffold protein binding GO:0097110 9.63 KCNH2 KCNQ1 SCN5A
8 sodium channel activity GO:0005272 9.61 HCN4 SCN5A TRPM4
9 voltage-gated sodium channel activity GO:0005248 9.52 HCN4 SCN5A
10 inward rectifier potassium channel activity GO:0005242 9.51 KCNE2 KCNH2
11 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 9.5 KCNE1 KCNH2 KCNQ1
12 delayed rectifier potassium channel activity GO:0005251 9.46 KCNE1 KCNE2 KCNH2 KCNQ1
13 voltage-gated potassium channel activity GO:0005249 9.35 HCN4 KCNE1 KCNE2 KCNH2 KCNQ1
14 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization GO:1902282 8.92 KCNE1 KCNE2 KCNH2 KCNQ1

Sources for Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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