MCID: ATR005
MIFTS: 50

Atrophic Gastritis malady

Gastrointestinal diseases category

Summaries for Atrophic Gastritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Atrophic gastritis (also known as Type A or Type B Gastritis more specifically) is a process of chronic... more...

MalaCards: Atrophic Gastritis, also known as gastritis, atrophic, is related to gastritis and pernicious anemia. An important gene associated with Atrophic Gastritis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways is Cytochrome P450 - arranged by substrate type. The compounds estrogen and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and t cells, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Atrophic Gastritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

atrophic gastritis 8 10
gastritis, atrophic 60
gastritis atrophic 44
gastric atrophy 8


External Ids:

Disease Ontology8 DOID:8929
ICD9CM27 535.1
MeSH34 D005757
NCIt39 C7405

Related Diseases for Atrophic Gastritis

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17GeneCards, 18GeneDecks
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Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Atrophic Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis32.1IL1RN, CDX2, GHRL, AREG, GAST, SCT
2pernicious anemia31.0GAST
3gastric ulcer30.9GHRL, GAST, S100A8
4stomach cancer30.8CDX2, GAST
5esophagitis30.7CDX2, GAST, S100A8
6duodenitis30.7S100A8, GAST
7adenocarcinoma30.7S100A8, SCT, GAST, AREG, GHRL, CHGA
8duodenal ulcer30.6S100A8, SCT, GAST, IL1RN
9gastric adenocarcinoma30.6S100A8, GAST, CHGA, MUC2, CDX2, IL1RN
10peptic ulcer30.5GAST, SCT, S100A8
11deficiency anemia30.4AREG, GHRL
12colorectal cancer30.4S100A8, GAST, AREG, MUC2, CDX2, IL1RN
13pancreatitis30.3SCT, ALDH2
14neuroendocrine carcinoma30.3CDX2, CHGA, GAST
15gastrinoma30.3CHGA, GAST, SCT
16squamous cell carcinoma30.3S100A8, AREG, CHGA, MUC2, CDX2, ALDH2
17gastroduodenitis30.1GAST
18neuroendocrine tumor30.1CHGA
19primary hyperparathyroidism30.1CHGA, GAST, SCT
20arthritis30.1S100A8, GHRL, IL1RN
21rheumatoid arthritis30.1S100A8, AREG, GHRL, IL1RN
22pancreatic cancer30.1SCT, GAST, MUC2, CDX2
23hyperparathyroidism30.1CHGA, GAST, SCT
24atherosclerosis30.1IL1RN, GHRL
25zollinger-ellison syndrome29.9CHGA, GAST, SCT
26iron deficiency anemia10.3
27alcoholic gastritis10.3
28autoimmune atrophic gastritis10.3
29gastric body carcinoma10.2
30bacterial gastritis10.2
31vitiligo10.2
32dementia10.2
33dermatitis10.2
34dermatitis herpetiformis10.2
35vitamin b12 deficiency10.2
36cardia cancer10.2
37gastric cardia adenocarcinoma10.1
38coronary artery disease10.1
39cholera10.1
40autoimmune thyroiditis10.1
41bile reflux10.1
42primary biliary cirrhosis10.1
43common variable immunodeficiency10.1
44duodenal gastrinoma10.1
45hyperhomocysteinemia10.1
46gastric squamous cell carcinoma10.1
47eosinophilic gastritis10.1
48lymphocytic gastritis10.1
49gastric gastrinoma10.1
50autoimmune hepatitis10.1

Graphical network of the top 20 diseases related to Atrophic Gastritis:



Diseases related to atrophic gastritis

Clinical Features for Atrophic Gastritis

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Drugs & Therapeutics for Atrophic Gastritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Atrophic Gastritis

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Anatomical Context for Atrophic Gastritis

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32MalaCards
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MalaCards organs/tissues related to Atrophic Gastritis:

32
Thyroid, Testes, T cells, Lymph node, B cells, Endothelial

Animal Models for Atrophic Gastritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Atrophic Gastritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0FUT2, CDX2, MUC2, AICDA, GHRL, AREG

Publications for Atrophic Gastritis

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50PubMed
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Articles related to Atrophic Gastritis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Gastric carcinoid in the absence of atrophic body gastritis and with low Ki67 index: a clinical challenge. (24417768)
2014
2
Serum prohepcidin levels are lower in patients with atrophic gastritis. (23533385)
2013
3
Refractory Iron-deficiency Anemia and Autoimmune Atrophic Gastritis in Pediatric Age Group: Analysis of 8 Clinical Cases. (24327126)
2013
4
Chronic autoimmune atrophic gastritis associated with primary hyperparathyroidism: a transversal prospective study. (23447517)
2013
5
Effects of traditional Chinese medicine Wei-Wei-Kang-Granule on the expression of EGFR and NF-KB in chronic atrophic gastritis rats. (23983313)
2012
6
Composite adenocarcinoma and carcinoid gastric tumor in chronic atrophic gastritis and pernicious anemia. (21552452)
2011
7
Performance of routine Helicobacter pylori tests in patients with atrophic gastritis. (22187698)
2011
8
The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis. (20381801)
2010
9
Incidence of chronic atrophic gastritis: systematic review and meta-analysis of follow-up studies. (20585973)
2010
10
Lu Zheng's experience in the treatment of atrophic gastritis. (20653172)
2010
11
Enhanced M1 macrophage polarization in human helicobacter pylori-associated atrophic gastritis and in vaccinated mice. (21124899)
2010
12
Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. (19906105)
2009
13
Regulatory T cells in type 1 diabetic patients with autoimmune chronic atrophic gastritis. (19291424)
2009
14
Association between a pro-inflammatory genetic profile and the risk of chronic atrophic gastritis among older adults from Germany. (19013788)
2009
15
Effect of mica monomer powder on chief and parietal cells as well as G and D cells in gastric mucosa of chronic atrophic gastritis in rats. (18219454)
2008
16
Serum biomarkers for atrophic gastritis and antibodies against Helicobacter pylori in the elderly: Implications for vitamin B12, folic acid and iron status and response to oral vitamin therapy. (18609169)
2008
17
Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. (18332421)
2008
18
Study on treatment principles for chronic atrophic gastritis. (18246683)
2007
19
Clinical research on acupuncture and moxibustion treatment of chronic atrophic gastritis. (17710798)
2007
20
Helicobacter pylori may be involved in cognitive impairment and dementia development through induction of atrophic gastritis, vitamin B-12 folate deficiency, and hyperhomocysteinemia sequence. (17823449)
2007
21
Morphological and pathologic changes of experimental chronic atrophic gastritis (CAG) and the regulating mechanism of protein expression in rats. (16845717)
2006
22
Interactions between gastric epithelial stem cells and Helicobacter pylori in the setting of chronic atrophic gastritis. (16406776)
2006
23
Atrophic gastritis in young children and adolescents. (16254110)
2005
24
Cell proliferation and inflammation on biopsy samples with multifocal atrophic gastritis before and 1 year after Helicobacter pylori eradication. (16253026)
2005
25
Effects of He-Ne laser irradiation on chronic atrophic gastritis in rats. (15991302)
2005
26
Diagnosis of atrophic gastritis from a serum sample. (16481967)
2003
27
In through the out door: serology for atrophic gastritis. (12867797)
2003
28
Long-term Helicobacter pylori infection in Japanese monkeys induces atrophic gastritis and accumulation of mutations in the p53 tumor suppressor gene. (12047319)
2002
29
Diagnosis of atrophic gastritis from a serum sample. (12389711)
2002
30
Extreme hypergastrinemia caused by atrophic gastritis and Helicobacter pylori infection--a case report. (11490838)
2001
31
Atrophic body gastritis patients with enterochromaffin-like cell dysplasia are at increased risk for the development of type I gastric carcinoid. (11742193)
2001
32
Does acid suppression by antacids and H2 receptor antagonists increase the incidence of atrophic gastritis in patients with or without H. pylori gastritis? (10478882)
1999
33
The role of the HLA-DQA1 gene in resistance to atrophic gastritis and gastric adenocarcinoma induced by Helicobacter pylori infection. (9506344)
1998
34
Familial occurrence of gastric carcinoid tumors associated with type A chronic atrophic gastritis. (9625140)
1998
35
Atrophic gastritis and Helicobacter pylori in reflux esophagitis. (8786770)
1996
36
O6-methylguanine in blood leucocyte DNA: an association with the geographic prevalence of gastric cancer and with low levels of serum pepsinogen A, a marker of severe chronic atrophic gastritis. The EUROGAST Study Group. (7923573)
1994
37
Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. (7706591)
1994
38
Helicobacter pylori infection and chronic atrophic gastritis among Japanese blood donors: a cross-sectional study. (8347779)
1993
39
Effect of beta-carotene supplementation on the activity of ornithine decarboxylase (ODC) in stomach mucosa of patients with chronic atrophic gastritis. (8428179)
1993
40
Atrophic gastritis and gastric carcinoid tumours. (2789800)
1989
41
High prevalence of atrophic gastritis in the elderly: implications for health-associated reference limits for cobalamin in serum. (2758623)
1989
42
47 cases of chronic atrophic gastritis treated with the modality of depressing the upward adverse flow of qi. (2630819)
1989
43
Radioimmunoassay of motilin in human plasma: interdigestive levels in normal subjects and in patients with hypergastrinemic chronic atrophic gastritis. (6530624)
1984
44
Atrophic gastritis classification. (6819928)
1982
45
Gastric acid secretion in chronic atrophic gastritis and chronic (superficial) gastritis. (887004)
1977
46
Effect of experimental immune atrophic gastritis on the induction of gastric carcinoma by X-irradiation in ICR mice. (1001863)
1976
47
Letter: Atrophic gastritis and dermatitis herpetiformis. (4143034)
1974
48
The gastric antibodies (intrinsic factor antibody and parietal cell antibody) and their clinical significances. (2). Pernicious anemia and atrophic gastritis. (4802621)
1973
49
A reappraisal of the nature and significance of chronic atrophic gastritis. (4573514)
1973
50
Effect of prolonged aministration of parietal cell antibodies from patients with atrophic gastritis and pernicious anemia on the parietal cell mass and hydrochloric acid output in rats. (4908769)
1970

Genetic Variations for Atrophic Gastritis

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Expression for genes affiliated with Atrophic Gastritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atrophic Gastritis

Search GEO for disease gene expression data for Atrophic Gastritis.

Pathways for genes affiliated with Atrophic Gastritis

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53Reactome
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Pathways related to Atrophic Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4ADH7, ALDH2

Compounds for genes affiliated with Atrophic Gastritis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Atrophic Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9AICDA
2ranitidine44 28 11 2413.8ADH7, SCT
3pepsinogen4410.7SCT, GAST, CHGA
4norepinephrine44 11 2412.7CHGA, AREG, GAST
5oxyntomodulin44 5911.7SCT, GAST, GHRL, CHGA
6amoxicillin44 49 1112.7IL1RN, GAST, S100A8
75-hydroxyindoleacetic acid44 2411.7GAST, CHGA, ALDH2
8octreotide44 59 28 1113.7SCT, GAST, GHRL, CHGA
9c-peptide4410.7CHGA, GHRL, GAST, SCT
10clarithromycin44 1111.7S100A8, GAST, IL1RN
11omeprazole44 28 49 11 2414.6ADH7, CHGA, GAST, SCT, S100A8
12dexamethasone44 49 28 1113.6S100A8, AREG, GHRL, MUC2
13acth4410.6SCT, GAST, GHRL, CHGA, IL1RN
14carbachol44 28 1112.6SCT, GAST, GHRL, CHGA
15carbohydrates4410.6GHRL, MUC2, IL1RN, FUT2
16lafutidine4410.6GAST, SCT
17famotidine44 2 11 2413.6ADH7, GHRL, GAST
18vitamin d4410.6GAST, GHRL, CHGA, CDX2, IL1RN
19acetaldehyde44 28 2412.6GAST, ALDH2, ADH7
20glp-1 (7-36)amide4410.6GAST, SCT
21histidine4410.6SCT, CTSW, GAST, GHRL, CHGA
22cimetidine44 28 1112.6SCT, GAST, ADH7
23epinephrine44 11 2412.6SCT, GAST, AREG, GHRL, CHGA, IL1RN
24paraffin4410.6S100A8, GHRL, CHGA, MUC2, CDX2
25hydrogen44 2411.6SCT, GAST, GHRL, CHGA, IL1RN, ALDH2
26isoproterenol44 1111.5CHGA, AREG, GAST, SCT
27polyacrylamide4410.5S100A8, GAST, AREG, CHGA, IL1RN, ALDH2
28prostaglandin4410.5IL1RN, GHRL, AREG, SCT
29creatinine4410.5S100A8, GAST, GHRL, CHGA, IL1RN, ALDH2
30histamine44 28 2412.5S100A8, SCT, GAST, GHRL, CHGA, IL1RN
31forskolin44 49 1112.5SCT, AREG, GHRL, CHGA, MUC2
32zinc44 2411.5S100A8, SCT, GHRL, CHGA, AICDA, IL1RN
33serine4410.5S100A8, SCT, GHRL, MUC2, IL1RN
34pancreozymin4410.5GAST, SCT
35testosterone44 59 11 2413.5SCT, GAST, AREG, GHRL, CHGA, IL1RN
36glucose4410.5SCT, GAST, GHRL, MUC2, FUT3, ALDH2
37cholesterol44 28 11 2413.5S100A8, GHRL, CHGA, MUC2, IL1RN, ALDH2
38secretoneurin4410.5CHGA, SCT
39oligonucleotide4410.5S100A8, SCT, AREG, CHGA, MUC2, CDX2
40glutamate4410.5S100A8, SCT, GAST, GHRL, CHGA, IL1RN
41retinoic acid44 2411.4S100A8, SCT, AREG, CHGA, MUC2, IL1RN
42dopamine44 28 11 2413.4SCT, GAST, GHRL, CHGA, ALDH2
43cysteine4410.4S100A8, SCT, CTSW, CHGA, MUC2, CDX2
44betaine aldehyde44 2411.4ADH7, ALDH2
45thymidine44 2411.4SCT, GAST, AREG, GHRL, CDX2
46atropine44 28 1112.3GHRL, GAST, SCT
47tyrosine4410.2S100A8, SCT, GAST, AREG, GHRL, CHGA
48alanine4410.2S100A8, GAST, GHRL, IL1RN, FUT3, ALDH2
49gaba4410.2SCT, GAST, GHRL, CHGA
50loxiglumide4410.1GAST, SCT

GO Terms for genes affiliated with Atrophic Gastritis

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16Gene Ontology
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Cellular components related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1ADH7, PGA4, CHGA, GHRL, GAST, SCT

Biological processes related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ethanol catabolic processGO:00606810.4ADH7, ALDH2
2ethanol oxidationGO:00606910.4ADH7, ALDH2
3negative regulation of interleukin-6 biosynthetic processGO:04540910.3GHRL, FOXJ1
4fucosylationGO:03606510.1FUT2, FUT3

Molecular functions related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fucosyltransferase activityGO:00841710.4FUT2, FUT3

Products for genes affiliated with Atrophic Gastritis

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Sources for Atrophic Gastritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet