MCID: ATR005
MIFTS: 50

Atrophic Gastritis malady

Gastrointestinal diseases category

Summaries for Atrophic Gastritis

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63Wikipedia, 32MalaCards
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Wikipedia:63 Atrophic gastritis (also known as Type A or Type B Gastritis more specifically) is a process of chronic... more...

MalaCards: Atrophic Gastritis, also known as gastritis, atrophic, is related to gastritis and pernicious anemia. An important gene associated with Atrophic Gastritis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways is Cytochrome P450 - arranged by substrate type. The compounds estrogen and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and t cells, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Atrophic Gastritis

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8Disease Ontology, 10DISEASES, 44Novoseek, 60UMLS, 56SNOMED-CT, 27ICD9CM, 34MeSH, 39NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

atrophic gastritis 8 10
gastritis, atrophic 60
gastritis atrophic 44
gastric atrophy 8


External Ids:

Disease Ontology8 DOID:8929
ICD9CM27 535.1
MeSH34 D005757
NCIt39 C7405

Related Diseases for Atrophic Gastritis

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17GeneCards, 18GeneDecks
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Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Atrophic Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis32.1IL1RN, CDX2, GHRL, AREG, GAST, SCT
2pernicious anemia31.0GAST
3gastric ulcer30.9GHRL, GAST, S100A8
4stomach cancer30.8CDX2, GAST
5esophagitis30.7CDX2, GAST, S100A8
6duodenitis30.7S100A8, GAST
7adenocarcinoma30.7S100A8, SCT, GAST, AREG, GHRL, CHGA
8duodenal ulcer30.6S100A8, SCT, GAST, IL1RN
9gastric adenocarcinoma30.6S100A8, GAST, CHGA, MUC2, CDX2, IL1RN
10peptic ulcer30.5GAST, SCT, S100A8
11deficiency anemia30.4AREG, GHRL
12colorectal cancer30.4S100A8, GAST, AREG, MUC2, CDX2, IL1RN
13pancreatitis30.3SCT, ALDH2
14neuroendocrine carcinoma30.3CDX2, CHGA, GAST
15gastrinoma30.3CHGA, GAST, SCT
16squamous cell carcinoma30.3S100A8, AREG, CHGA, MUC2, CDX2, ALDH2
17gastroduodenitis30.1GAST
18neuroendocrine tumor30.1CHGA
19primary hyperparathyroidism30.1CHGA, GAST, SCT
20arthritis30.1S100A8, GHRL, IL1RN
21rheumatoid arthritis30.1S100A8, AREG, GHRL, IL1RN
22pancreatic cancer30.1SCT, GAST, MUC2, CDX2
23hyperparathyroidism30.1CHGA, GAST, SCT
24atherosclerosis30.1IL1RN, GHRL
25zollinger-ellison syndrome29.9CHGA, GAST, SCT
26iron deficiency anemia10.3
27alcoholic gastritis10.3
28autoimmune atrophic gastritis10.3
29gastric body carcinoma10.2
30bacterial gastritis10.2
31vitiligo10.2
32dementia10.2
33dermatitis10.2
34dermatitis herpetiformis10.2
35vitamin b12 deficiency10.2
36cardia cancer10.2
37gastric cardia adenocarcinoma10.1
38coronary artery disease10.1
39cholera10.1
40autoimmune thyroiditis10.1
41bile reflux10.1
42primary biliary cirrhosis10.1
43common variable immunodeficiency10.1
44duodenal gastrinoma10.1
45hyperhomocysteinemia10.1
46gastric squamous cell carcinoma10.1
47eosinophilic gastritis10.1
48lymphocytic gastritis10.1
49gastric gastrinoma10.1
50autoimmune hepatitis10.1

Graphical network of the top 20 diseases related to Atrophic Gastritis:



Diseases related to atrophic gastritis

Clinical Features for Atrophic Gastritis

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Drugs & Therapeutics for Atrophic Gastritis

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Atrophic Gastritis

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Anatomical Context for Atrophic Gastritis

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32MalaCards
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MalaCards organs/tissues related to Atrophic Gastritis:

32
Thyroid, Testes, T cells, Lymph node, B cells, Endothelial

Animal Models for Atrophic Gastritis or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Atrophic Gastritis:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0FUT2, CDX2, MUC2, AICDA, GHRL, AREG

Publications for Atrophic Gastritis

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50PubMed
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Articles related to Atrophic Gastritis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Prevalence and risk factors of atrophic gastritis and intestinal metaplasia: a nationwide multicenter prospective study in Korea. (23710311)
2013
2
Atrophic gastritis: risk factor for esophageal squamous cell carcinoma in a Latin-American population. (23599625)
2013
3
Apigenin has anti-atrophic gastritis and anti-gastric cancer progression effects in Helicobacter pylori-infected Mongolian gerbils. (24374236)
2013
4
Serum gastrin 17, pepsinogen I and pepsinogen II in atrophic gastritis patients living in North-East of Iran. (23930120)
2013
5
Helicobacter pylori infection and atrophic gastritis. (23658576)
2013
6
Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1I^, and atrophic gastritis in mice. (22079592)
2012
7
No higher risk for colorectal cancer in atrophic gastritis-related hypergastrinemia. (22595617)
2012
8
Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma biomarkers. (22242613)
2012
9
Oxidative DNA damage and repair in chronic atrophic gastritis and gastric cancer. (22469707)
2012
10
Caveolin-1, E-cadherin and I^-catenin in Gastric Carcinoma, Precancerous Tissues and Chronic Non-atrophic Gastritis. (23359759)
2012
11
The influence of the type of ulcers in the degree of atrophic gastritis. (21534446)
2011
12
From open-type atrophic gastritis to gastritis staging. (21519824)
2011
13
Long-term proton pump inhibitor administration worsens atrophic corpus gastritis and promotes adenocarcinoma development in Mongolian gerbils infected with Helicobacter pylori. (21097844)
2011
14
The regenerating gene iI+ is overexpressed in atrophic gastritis rats with hypergastrinemia. (21949663)
2011
15
Development of type I gastric carcinoid in patients with chronic atrophic gastritis. (21492197)
2011
16
Validation of diagnostic tests for Helicobacter pylori with regard to grade of atrophic gastritis and/or intestinal metaplasia. (19889068)
2009
17
Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: The Kalixanda study. (18663663)
2008
18
Atrophic gastritis: deficient complex I of the respiratory chain in the mitochondria of corpus mucosal cells. (18958547)
2008
19
Atrophic gastritis, but not antibody to Helicobacter pylori, is associated with body mass index in a Japanese population. (18958544)
2008
20
Plasma ghrelin concentrations in type 1 diabetic patients with autoimmune atrophic gastritis. (18057384)
2007
21
Helicobacter pylori-induced atrophic gastritis progressing to gastric cancer exhibits sonic hedgehog loss and aberrant CDX2 expression. (17209848)
2006
22
Severe lymphocytic-plasmacytic and atrophic gastritis, as well as, predominantly eosinophilic, severe enteritis, in a 19-month-old Labrador retriever. (15884651)
2005
23
Real-time detection of Helicobacter Pylori infection and atrophic gastritis: comparison between conventional methods and a novel device for gastric juice analysis during endoscopy. (16189769)
2005
24
Upregulation of cathepsin W-expressing T cells is specific for autoimmune atrophic gastritis compared to other types of chronic gastritis. (16273605)
2005
25
Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. (16284368)
2005
26
Association of tumor necrosis factor genetic polymorphism with chronic atrophic gastritis and gastric adenocarcinoma in Chinese Han population. (15112338)
2004
27
A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. (12891537)
2003
28
Atrophic corpus gastritis and Helicobacter pylori infection in primary biliary cirrhosis. (11837719)
2002
29
Effects of polyunsaturated fatty acids on atrophic gastritis in a Japanese population. (11165751)
2001
30
Atrophic gastritis and Helicobacter pylori infection in outpatients referred for gastroscopy. (10716672)
2000
31
Gastric emptying and dyspeptic symptoms in patients with nonautoimmune fundic atrophic gastritis. (10711434)
2000
32
Expression of bcl-2 in autoimmune and Helicobacter pylori-associated atrophic gastritis. (10219822)
1999
33
Cell damage and proliferation in human gastric mucosa infected by Helicobacter pylori--a comparison before and after H pylori eradication in non-atrophic gastritis. (10667417)
1999
34
Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis. (9620430)
1998
35
Severe atrophic gastritis with Helicobacter pylori infection and gastric cancer. (11957055)
1998
36
A follow-up study of atrophic gastritis and intestinal metaplasia after eradication of Helicobacter pylori. (9844064)
1998
37
Chronic atrophic gastritis and Helicobacter pylori infection in primary biliary cirrhosis: a cross-sectional study with matching. (9265572)
1997
38
Helicobacter pylori infection is the major risk factor for atrophic gastritis. (8633588)
1996
39
Relationship between Helicobacter pylori and atrophic gastritis. (7735942)
1994
40
Fundal atrophic gastritis as a risk factor for gastric cancer. (8416206)
1993
41
Types of atrophic gastritis in patients with primary SjAPgren's syndrome. (1998399)
1991
42
Cell renewal and cancer risk of the stomach: analysis of cell proliferation kinetics in atrophic gastritis. (2637580)
1989
43
Mutagenic activity in gastric juice and urine of subjects with chronic atrophic gastritis, gastric epithelial dysplasia and gastric cancer. (2605566)
1989
44
Hematopoietic and gastric uracil-DNA glycosylase activity in megaloblastic anemia and in atrophic gastritis with special reference to pernicious anemia. (3802419)
1987
45
Folic acid malabsorption in atrophic gastritis. Possible compensation by bacterial folate synthesis. (3770372)
1986
46
A double-blind study of effectiveness of hericium erinaceus pers therapy on chronic atrophic gastritis. A preliminary report. (3932005)
1985
47
Gastric gastrinoma and diffuse G cell hyperplasia associated with chronic atrophic gastritis. Endoscopic detection and removal. (6250933)
1980
48
An appraisal of tests for severe atrophic gastritis in relatives of patients with pernicious anemia. (456206)
1979
49
Atrophic gastritis: a possible pre-cancerous condition. (4843958)
1974
50
Progressive increase in the functional G cell mass with age in atrophic gastritis. (4729922)
1973

Genetic Variations for Atrophic Gastritis

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Expression for genes affiliated with Atrophic Gastritis

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atrophic Gastritis

Search GEO for disease gene expression data for Atrophic Gastritis.

Pathways for genes affiliated with Atrophic Gastritis

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53Reactome
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Pathways related to Atrophic Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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10.4ADH7, ALDH2

Compounds for genes affiliated with Atrophic Gastritis

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44Novoseek, 28IUPHAR, 11DrugBank, 24HMDB, 59Tocris Bioscience, 49PharmGKB, 2BitterDB
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Compounds related to Atrophic Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1estrogen4410.9AICDA
2ranitidine44 28 11 2413.8ADH7, SCT
3pepsinogen4410.7SCT, GAST, CHGA
4norepinephrine44 11 2412.7CHGA, GAST, AREG
5oxyntomodulin44 5911.7GHRL, GAST, SCT, CHGA
6amoxicillin44 49 1112.7IL1RN, GAST, S100A8
75-hydroxyindoleacetic acid44 2411.7GAST, CHGA, ALDH2
8octreotide44 59 28 1113.7GAST, CHGA, SCT, GHRL
9c-peptide4410.7GAST, GHRL, CHGA, SCT
10clarithromycin44 1111.7IL1RN, GAST, S100A8
11omeprazole44 28 49 11 2414.6SCT, GAST, CHGA, S100A8, ADH7
12dexamethasone44 49 28 1113.6S100A8, AREG, GHRL, MUC2
13acth4410.6IL1RN, SCT, GHRL, GAST, CHGA
14carbachol44 28 1112.6SCT, GAST, GHRL, CHGA
15carbohydrates4410.6FUT2, MUC2, IL1RN, GHRL
16glp-1 (7-36)amide4410.6SCT, GAST
17famotidine44 2 11 2413.6ADH7, GAST, GHRL
18vitamin d4410.6GAST, CDX2, CHGA, IL1RN, GHRL
19acetaldehyde44 28 2412.6GAST, ALDH2, ADH7
20lafutidine4410.6SCT, GAST
21histidine4410.6CHGA, GHRL, GAST, CTSW, SCT
22cimetidine44 28 1112.6SCT, GAST, ADH7
23epinephrine44 11 2412.6AREG, SCT, GHRL, CHGA, GAST, IL1RN
24paraffin4410.6S100A8, GHRL, CHGA, MUC2, CDX2
25hydrogen44 2411.6ALDH2, IL1RN, SCT, GAST, GHRL, CHGA
26isoproterenol44 1111.5SCT, GAST, AREG, CHGA
27polyacrylamide4410.5GAST, CHGA, AREG, S100A8, IL1RN, ALDH2
28prostaglandin4410.5IL1RN, GHRL, SCT, AREG
29creatinine4410.5S100A8, GAST, CHGA, ALDH2, IL1RN, GHRL
30histamine44 28 2412.5SCT, IL1RN, S100A8, GAST, GHRL, ALDH2
31secretoneurin4410.5CHGA, SCT
32forskolin44 49 1112.5AREG, GHRL, MUC2, CHGA, SCT
33zinc44 2411.5S100A8, SCT, GHRL, CHGA, IL1RN, AICDA
34serine4410.5MUC2, S100A8, GHRL, SCT, IL1RN
35testosterone44 59 11 2413.5AREG, IL1RN, SCT, CHGA, GHRL, GAST
36glucose4410.5ALDH2, FUT3, MUC2, GHRL, GAST, SCT
37cholesterol44 28 11 2413.5CHGA, GHRL, S100A8, MUC2, IL1RN, ALDH2
38oligonucleotide4410.5CHGA, SCT, S100A8, MUC2, CDX2, ALDH2
39glutamate4410.5IL1RN, CHGA, GHRL, GAST, SCT, S100A8
40pancreozymin4410.5GAST, SCT
41retinoic acid44 2411.4ADH7, AREG, ALDH2, MUC2, IL1RN, CHGA
42dopamine44 28 11 2413.4ALDH2, CHGA, GAST, GHRL, SCT
43cysteine4410.4FUT3, CDX2, CHGA, SCT, CTSW, IL1RN
44betaine aldehyde44 2411.4ADH7, ALDH2
45thymidine44 2411.4AREG, GHRL, SCT, GAST, CDX2
46atropine44 28 1112.3GAST, GHRL, SCT
47tyrosine4410.2CHGA, S100A8, SCT, GAST, AREG, IL1RN
48alanine4410.2GAST, ALDH2, FUT3, IL1RN, GHRL, S100A8
49gaba4410.2CHGA, GHRL, GAST, SCT
50loxiglumide4410.1GAST, SCT

GO Terms for genes affiliated with Atrophic Gastritis

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16Gene Ontology
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Cellular components related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1ADH7, PGA4, CHGA, GHRL, GAST, SCT

Biological processes related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ethanol catabolic processGO:00606810.4ADH7, ALDH2
2ethanol oxidationGO:00606910.4ADH7, ALDH2
3negative regulation of interleukin-6 biosynthetic processGO:04540910.3GHRL, FOXJ1
4fucosylationGO:03606510.1FUT2, FUT3

Molecular functions related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fucosyltransferase activityGO:00841710.4FUT2, FUT3

Products for genes affiliated with Atrophic Gastritis

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Sources for Atrophic Gastritis

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet