MCID: ATR005
MIFTS: 48

Atrophic Gastritis malady

Gastrointestinal category

Summaries for Atrophic Gastritis

Sources:
64Wikipedia, 33MalaCards
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Wikipedia:64 Atrophic gastritis (also known as Type A or Type B Gastritis more specifically) is a process of chronic... more...

MalaCards: Atrophic Gastritis, also known as gastritis, atrophic, is related to pernicious anemia and gastric ulcer. An important gene associated with Atrophic Gastritis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways is Cytochrome P450 - arranged by substrate type. The compounds estrogen and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include whole blood, lymph node and thyroid, and related mouse phenotype digestive/alimentary.

Aliases & Classifications for Atrophic Gastritis

Sources:
8Disease Ontology, 10DISEASES, 45Novoseek, 61UMLS, 57SNOMED-CT, 27ICD9CM, 35MeSH, 40NCIt
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Gastrointestinal


Aliases & Descriptions:

atrophic gastritis 8 10
gastritis, atrophic 61
gastritis atrophic 45
gastric atrophy 8


External Ids:

Disease Ontology8 DOID:8929
ICD9CM27 535.1
MeSH35 D005757
NCIt40 C7405

Related Diseases for Atrophic Gastritis

Sources:
17GeneCards, 18GeneDecks
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Diseases in the Atrophic Gastritis family:

autoimmune atrophic gastritis

Diseases related to Atrophic Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 121)
idRelated DiseaseScoreTop Affiliating Genes
1pernicious anemia31.0GAST
2gastric ulcer31.0GHRL, GAST, S100A8
3stomach cancer30.8CDX2, GAST
4adenocarcinoma30.7S100A8, SCT, GAST, AREG, GHRL, CHGA
5duodenal ulcer30.6S100A8, SCT, GAST, IL1RN
6deficiency anemia30.5AREG, GHRL
7colorectal cancer30.5S100A8, GAST, AREG, MUC2, CDX2, IL1RN
8neuroendocrine carcinoma30.3CDX2, CHGA, GAST
9gastrinoma30.3CHGA, GAST, SCT
10carcinoid syndrome30.3SCT, GAST, GHRL, CHGA, CDX2
11squamous cell carcinoma30.3S100A8, AREG, CHGA, MUC2, CDX2, ALDH2
12primary hyperparathyroidism30.1CHGA, GAST, SCT
13arthritis30.1S100A8, GHRL, IL1RN
14atherosclerosis30.1IL1RN, GHRL
15zollinger-ellison syndrome29.9CHGA, GAST, SCT
16h. pylori infection11.0
17autoimmune atrophic gastritis10.8
18iron deficiency anemia10.3
19gastric body carcinoma10.2
20bacterial gastritis10.2
21alcoholic gastritis10.2
22vitiligo10.2
23esophageal squamous cell carcinoma10.2
24cardia cancer10.2
25coronary artery disease,10.1
26cholera10.1
27autoimmune thyroiditis10.1
28hepatitis e10.1
29bile reflux10.1
30primary biliary cirrhosis10.1
31common variable immunodeficiency10.1
32duodenal gastrinoma10.1
33hyperhomocysteinemia10.1
34gastric squamous cell carcinoma10.1
35eosinophilic gastritis10.1
36lymphocytic gastritis10.1
37gastric gastrinoma10.1
38autoimmune hepatitis10.1
39hepatitis d10.1
40hypersplenism10.1
41exocrine pancreatic insufficiency10.1
42megaloblastic anemia10.1
43n syndrome10.1
44hepatitis a10.1
45thyroiditis10.1
46thyrotoxicosis10.1
47iron-refractory iron deficiency anemia10.1
48autoimmune enteropathy10.1
49intrinsic factor deficiency10.1
50mthfr deficiency10.1

Graphical network of the top 20 diseases related to Atrophic Gastritis:



Diseases related to atrophic gastritis

Clinical Features for Atrophic Gastritis

Drugs & Therapeutics for Atrophic Gastritis

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Atrophic Gastritis

Drug clinical trials:

Search ClinicalTrials for Atrophic Gastritis

Search NIH Clinical Center for Atrophic Gastritis

Search CenterWatch for Atrophic Gastritis

Genetic Tests for Atrophic Gastritis

Anatomical Context for Atrophic Gastritis

Sources:
33MalaCards
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MalaCards organs/tissues related to Atrophic Gastritis:

33
Whole blood, Lymph node, Thyroid, T cells, B cells, Endothelial

Animal Models for Atrophic Gastritis or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Atrophic Gastritis:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538110.0FUT2, CDX2, MUC2, AICDA, GHRL, AREG

Publications for Atrophic Gastritis

Sources:
51PubMed
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Articles related to Atrophic Gastritis:

(show top 50)    (show all 530)
idTitleAuthorsYear
1
Histologic changes in type A chronic atrophic gastritis indicating increased risk of neuroendocrine tumor development: the predictive role of dysplastic and severely hyperplastic enterochromaffin-like cell lesions. (23642738)
2013
2
Autoimmune atrophic gastritis--pathogenesis, pathology and management. (23774773)
2013
3
Are the serum biomarkers pepsinogen I and II good predictors for the detection of subjects with atrophic gastritis in areas that have different gastric cancer incidence? (23496362)
2013
4
Vitamin C supplementation in relation to inflammation in individuals with atrophic gastritis: a randomised controlled trial in Japan. (23167953)
2013
5
Heat shock protein 27 expression is inversely correlated with atrophic gastritis and intraepithelial neoplasia. (22886594)
2013
6
Analysis of alarming signals for the progression of atrophic gastritis to dysplasia. (23039799)
2012
7
Genome sequences of three Helicobacter pylori strains isolated from atrophic gastritis and gastric ulcer patients in China. (23105058)
2012
8
Gastric juice prostaglandins and peptide growth factors as potential markers of chronic atrophic gastritis, intestinal metaplasia and gastric cancer: their potential clinical implications based on this pilot study. (21695403)
2011
9
ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infection. (21680535)
2011
10
Incidence and risk factors for the development of chronic atrophic gastritis: five year follow-up of a population-based cohort study. (20503273)
2011
11
Development of corpus atrophic gastritis may be associated with Helicobacter pylori-related idiopathic thrombocytopenic purpura. (21594563)
2011
12
High-protein diet suppresses corpus atrophic gastritis in Helicobacter pylori infected Mongolian gerbils. (21058194)
2010
13
Atrophic gastritis and the risk of incident colorectal cancer. (19838812)
2010
14
Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. (19320631)
2009
15
Response of gastric epithelial progenitors to Helicobacter pylori Isolates obtained from Swedish patients with chronic atrophic gastritis. (19723631)
2009
16
Combined carcinoid and mixed (composite) glandular - endocrine cell carcinoma of the stomach in atrophic gastritis. (19365883)
2009
17
Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms. (19030199)
2008
18
Association of Helicobacter pylori infection with chronic atrophic gastritis: Meta-analyses according to type of disease definition. (18484586)
2008
19
Influence of H pylori on plasma ghrelin in patients without atrophic gastritis. (17461454)
2007
20
Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations. (16638096)
2006
21
Relationship between Helicobacter pylori status and serum pepsinogens as serologic markers in atrophic gastritis. (16941249)
2006
22
Atrophic gastritis is associated with increased sucrose permeability related to chronic inflammation. (16244483)
2005
23
Is there a possible relation between atrophic gastritis and premature atherosclerosis? (16302990)
2005
24
Intracellular VacA is a valuable marker to predict whether Helicobacter pylori induces progressive atrophic gastritis that is associated with the development of gastric cancer. (15712638)
2005
25
Prof. Shan Zhaowei's experience in treating chronic atrophic gastritis. (15688688)
2004
26
Cigarette smoking promotes atrophic gastritis in Helicobacter pylori-positive subjects. (11911358)
2002
27
Omeprazole and accelerated onset of atrophic gastritis. (10644182)
2000
28
Increase in apoptosis and decrease in ornithine decarboxylase activity of the gastric mucosa in patients with atrophic gastritis and gastric ulcer after successful eradication of Helicobacter pylori. (10483998)
1999
29
Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. (10405229)
1999
30
Autoimmune enteropathy with severe atrophic gastritis and colitis in an adult: proposal of a generalized autoimmune disorder of the alimentary tract. (9712235)
1998
31
A topographic analysis of atrophic gastritis and stomach cancer risk. A clinicoepidemiological study in Poland. (9386896)
1997
32
The gastrin and pepsinogen levels of patients with chronic atrophic gastritis and duodenal ulcer]. (8191737)
1993
33
Primary SjAPgren's syndrome associated with chronic atrophic gastritis and pernicious anemia. (8463619)
1993
34
Helicobacter pylori and atrophic gastritis. (1523687)
1992
35
Occurrence of autoantibodies against intrinsic factor, H,K-ATPase, and pepsinogen in atrophic gastritis and rheumatoid arthritis. (1658920)
1991
36
Treatment of 910 cases of atrophic gastritis with wei you decoction. (2277511)
1990
37
Pernicious anemia and type A atrophic gastritis in the Chinese. (2114961)
1990
38
Incidence of atrophic gastritis with age in Japan and Canada. (3626154)
1987
39
The syndrome of type A chronic atrophic gastritis, pernicious anemia, and multiple gastric carcinoids. (3517132)
1986
40
Gastric cancer risk in chronic atrophic gastritis: statistical calculations of cross-sectional data. (3871738)
1985
41
Gastric carcinoids and atrophic gastritis. Evidence for an association. (6847375)
1983
42
Atrophic gastritis in a Hermann's tortoise (Testudo hermanni) and two red-eared turtles (Chrysemys scripta elegans). (7340590)
1981
43
Induction of atrophic gastritis in ICR mice by the administration of an allogenic antigen. (605795)
1977
44
Serum gastrin and atrophic gastritis in achlorhydric patients with and without pernicious anemia. (996437)
1976
45
Autoimmune atrophic gastritis with hypergastrinemia. (1019670)
1976
46
The diagnosis of atrophic gastritis. (4695652)
1973
47
The immunological quantification of an acid-stable carboxyl esterase in the gastric juice of patients with pernicious anemia and chronic atrophic gastritis. (4772022)
1973
48
The effect of gastric antigens on the in vitro migration of leucocytes from patients with atrophic gastritis and pernicious anaemia. (4747581)
1973
49
Patterns of nucleic acid and protein synthesis in normal human gastric mucosa and atrophic gastritis. (5056249)
1972
50
Experimental atrophic gastritis. (5077153)
1972

Genetic Variations for Atrophic Gastritis

Expression for genes affiliated with Atrophic Gastritis

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atrophic Gastritis

Search GEO for disease gene expression data for Atrophic Gastritis.

Pathways for genes affiliated with Atrophic Gastritis

Sources:
54Reactome
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Pathways related to Atrophic Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
10.4ADH7, ALDH2

Compounds for genes affiliated with Atrophic Gastritis

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 60Tocris Bioscience, 50PharmGKB, 2BitterDB
See all sources

Compounds related to Atrophic Gastritis according to GeneCards/GeneDecks:

(show top 50)    (show all 63)
idCompoundScoreTop Affiliating Genes
1estrogen4510.9AICDA
2ranitidine45 29 11 2413.8ADH7, SCT
3pepsinogen4510.7SCT, GAST, CHGA
4norepinephrine45 11 2412.7CHGA, GAST, AREG
5oxyntomodulin45 6011.7GHRL, GAST, SCT, CHGA
6amoxicillin45 50 1112.7IL1RN, GAST, S100A8
75-hydroxyindoleacetic acid45 2411.7GAST, CHGA, ALDH2
8octreotide45 60 29 1113.7GAST, CHGA, SCT, GHRL
9c-peptide4510.7GAST, GHRL, CHGA, SCT
10clarithromycin45 1111.7IL1RN, GAST, S100A8
11omeprazole45 29 50 11 2414.6SCT, GAST, CHGA, S100A8, ADH7
12dexamethasone45 50 29 1113.6S100A8, AREG, GHRL, MUC2
13acth4510.6IL1RN, SCT, GHRL, GAST, CHGA
14carbachol45 29 1112.6SCT, GAST, GHRL, CHGA
15carbohydrates4510.6FUT2, MUC2, IL1RN, GHRL
16glp-1 (7-36)amide4510.6SCT, GAST
17famotidine45 2 11 2413.6ADH7, GAST, GHRL
18vitamin d4510.6GAST, CDX2, CHGA, IL1RN, GHRL
19acetaldehyde45 29 2412.6GAST, ALDH2, ADH7
20lafutidine4510.6SCT, GAST
21histidine4510.6CHGA, GHRL, GAST, CTSW, SCT
22cimetidine45 29 1112.6SCT, GAST, ADH7
23epinephrine45 11 2412.6AREG, SCT, GHRL, CHGA, GAST, IL1RN
24paraffin4510.6S100A8, GHRL, CHGA, MUC2, CDX2
25hydrogen45 2411.6ALDH2, IL1RN, SCT, GAST, GHRL, CHGA
26isoproterenol45 1111.5SCT, GAST, AREG, CHGA
27polyacrylamide4510.5GAST, CHGA, AREG, S100A8, IL1RN, ALDH2
28prostaglandin4510.5IL1RN, GHRL, SCT, AREG
29creatinine4510.5S100A8, GAST, CHGA, ALDH2, IL1RN, GHRL
30histamine45 29 2412.5SCT, IL1RN, S100A8, GAST, GHRL, ALDH2
31secretoneurin4510.5CHGA, SCT
32forskolin45 50 1112.5AREG, GHRL, MUC2, CHGA, SCT
33zinc45 2411.5S100A8, SCT, GHRL, CHGA, IL1RN, AICDA
34serine4510.5MUC2, S100A8, GHRL, SCT, IL1RN
35testosterone45 60 11 2413.5AREG, IL1RN, SCT, CHGA, GHRL, GAST
36glucose4510.5ALDH2, FUT3, MUC2, GHRL, GAST, SCT
37cholesterol45 29 11 2413.5CHGA, GHRL, S100A8, MUC2, IL1RN, ALDH2
38oligonucleotide4510.5CHGA, SCT, S100A8, MUC2, CDX2, ALDH2
39glutamate4510.5IL1RN, CHGA, GHRL, GAST, SCT, S100A8
40pancreozymin4510.5GAST, SCT
41retinoic acid45 2411.4ADH7, AREG, ALDH2, MUC2, IL1RN, CHGA
42dopamine45 29 11 2413.4ALDH2, CHGA, GAST, GHRL, SCT
43cysteine4510.4FUT3, CDX2, CHGA, SCT, CTSW, IL1RN
44betaine aldehyde45 2411.4ADH7, ALDH2
45thymidine45 2411.4AREG, GHRL, SCT, GAST, CDX2
46atropine45 29 1112.3GAST, GHRL, SCT
47tyrosine4510.2CHGA, S100A8, SCT, GAST, AREG, IL1RN
48alanine4510.2GAST, ALDH2, FUT3, IL1RN, GHRL, S100A8
49gaba4510.2CHGA, GHRL, GAST, SCT
50loxiglumide4510.1GAST, SCT

GO Terms for genes affiliated with Atrophic Gastritis

Sources:
16Gene Ontology
See all sources

Cellular components related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:00557610.1ADH7, PGA4, CHGA, GHRL, GAST, SCT

Biological processes related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1ethanol catabolic processGO:00606810.4ADH7, ALDH2
2ethanol oxidationGO:00606910.4ADH7, ALDH2
3negative regulation of interleukin-6 biosynthetic processGO:04540910.3GHRL, FOXJ1
4fucosylationGO:03606510.1FUT2, FUT3

Molecular functions related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fucosyltransferase activityGO:00841710.4FUT2, FUT3

Products for genes affiliated with Atrophic Gastritis

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  • Proteins
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Sources for Atrophic Gastritis

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet