MCID: ATR005
MIFTS: 46

Atrophic Gastritis malady

Gastrointestinal diseases, Rare diseases categories
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Summaries for Atrophic Gastritis

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65Wikipedia, 33MalaCards
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Wikipedia:65 Atrophic gastritis (also known as Type A or Type B Gastritis more specifically) is a process of chronic... more...

MalaCards: Atrophic Gastritis, also known as gastritis, atrophic, is related to gastritis and gastric ulcer. An important gene associated with Atrophic Gastritis is CHGA (chromogranin A (parathyroid secretory protein 1)), and among its related pathways are Peptide hormone metabolism and Glycosphingolipid biosynthesis - lacto and neolacto series. The compounds oxyntomodulin and ranitidine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, testes and t cells.

Aliases & Classifications for Atrophic Gastritis

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8Disease Ontology, 10DISEASES, 45Novoseek, 62UMLS, 35MeSH, 27ICD9CM, 58SNOMED-CT, 40NCIt
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases
Anatomical: Gastrointestinal diseases


Aliases & Descriptions:

atrophic gastritis 8 10
gastritis, atrophic 62
gastritis atrophic 45
gastric atrophy 8


External Ids:

Disease Ontology8 DOID:8929
MeSH35 D005757
ICD9CM27 535.1
NCIt40 C7405

Related Diseases for Atrophic Gastritis

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17GeneCards, 18GeneDecks
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Diseases in the Atrophic Gastritis family:

Autoimmune Atrophic Gastritis

Diseases related to Atrophic Gastritis via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1gastritis32.3CDX2, GHRL
2gastric ulcer30.9ODC1, GHRL
3stomach cancer30.8ODC1, CDX2, CHGA
4adenocarcinoma30.7CDX2, CHGA, GHRL, ODC1
5gastric adenocarcinoma30.5CHGA, ODC1, CDX2
6colorectal cancer30.4CDX2, GHRL, FUT3, ODC1
7neuroendocrine carcinoma30.2CDX2, CHGA
8pancreatic cancer30.2CHGA, CDX2
9neuroendocrine tumor30.2CDX2, GHRL, CHGA
10autoimmune atrophic gastritis10.7
11pernicious anemia10.7
12esophagitis10.5
13duodenitis10.5
14duodenal ulcer10.5
15deficiency anemia10.4
16iron deficiency anemia10.4
17h. pylori infection10.4
18gastrinoma10.3
19vitiligo10.3
20dementia10.3
21dermatitis10.3
22dermatitis herpetiformis10.3
23pancreatitis10.3
24vitamin b12 deficiency10.3
25esophageal squamous cell carcinoma10.3
26coronary artery disease10.1
27cholera10.1
28duodenal gastrinoma10.1
29hyperhomocysteinemia10.1
30gastric gastrinoma10.1
31autoimmune hepatitis10.1
32hypersplenism10.1
33gastroduodenitis10.1
34addison's disease10.1
35primary hyperparathyroidism10.1
36primary biliary cirrhosis10.1
37common variable immunodeficiency10.1
38megaloblastic anemia10.1
39exocrine pancreatic insufficiency10.1
40artery disease10.1
41arthritis10.1
42atherosclerosis10.1
43hepatitis10.1
44hyperparathyroidism10.1
45myasthenia gravis10.1
46purpura10.1
47rheumatoid arthritis10.1
48thyroiditis10.1
49thyrotoxicosis10.1
50autoimmune enteropathy10.1

Graphical network of the top 20 diseases related to Atrophic Gastritis:



Diseases related to atrophic gastritis

Symptoms for Atrophic Gastritis

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Drugs & Therapeutics for Atrophic Gastritis

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Sources:
42NIH Clinical Center, 6ClinicalTrials, 62UMLS, 41NDF-RT
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Drug clinical trials:

Search ClinicalTrials for Atrophic Gastritis

Search NIH Clinical Center for Atrophic Gastritis

Genetic Tests for Atrophic Gastritis

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Anatomical Context for Atrophic Gastritis

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33MalaCards
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MalaCards organs/tissues related to Atrophic Gastritis:

33
Thyroid, Testes, T cells, Lymph node, B cells, Endothelial

Animal Models for Atrophic Gastritis or affiliated genes

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Publications for Atrophic Gastritis

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52PubMed
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Articles related to Atrophic Gastritis:

(show top 50)    (show all 503)
idTitleAuthorsYear
1
Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. (24123036)
2013
2
Prevalence and risk factors of atrophic gastritis and intestinal metaplasia: a nationwide multicenter prospective study in Korea. (23710311)
2013
3
Prevalence of Helicobacter pylori infection and atrophic gastritis in Latvia. (23114744)
2012
4
Autoimmune atrophic gastritis presenting as myelopathy in a young patient. (22899041)
2012
5
Gastric juice prostaglandins and peptide growth factors as potential markers of chronic atrophic gastritis, intestinal metaplasia and gastric cancer: their potential clinical implications based on this pilot study. (21695403)
2011
6
The influence of the type of ulcers in the degree of atrophic gastritis. (21534446)
2011
7
From open-type atrophic gastritis to gastritis staging. (21519824)
2011
8
High-protein diet suppresses corpus atrophic gastritis in Helicobacter pylori infected Mongolian gerbils. (21058194)
2010
9
The staging of gastritis with the OLGA system by using intestinal metaplasia as an accurate alternative for atrophic gastritis. (20381801)
2010
10
No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese. (20373075)
2010
11
Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans. (19906105)
2009
12
Chronic atrophic gastritis and metachronous gastric cancer in Japanese alcoholic men with esophageal squamous cell carcinoma. (19320631)
2009
13
Helicobacter pylori infection and chronic atrophic gastritis: associations according to severity of disease. (19404195)
2009
14
Role of transforming growth factor beta1 in the development of atrophic gastritis]. (20019772)
2009
15
Rapid regression of multiple gastric carcinoid tumors with hypergastrinemia and atrophic gastritis after renal transplantation. (17763955)
2008
16
Serum biomarkers provide an accurate method for diagnosis of atrophic gastritis in a general population: The Kalixanda study. (18663663)
2008
17
Extensive atrophic gastritis linked to increased levels of intraluminal hydrogen gas. (19102360)
2008
18
Study on treatment principles for chronic atrophic gastritis. (18246683)
2007
19
Protective effects of heat shock protein70 induced by geranylgeranylacetone in atrophic gastritis in rats. (17588336)
2007
20
Severity of atrophic gastritis related to antiparietal cell antibody and gastric carcinogenesis, including p53 mutations. (16638096)
2006
21
Comparison of prevalence of chronic atrophic gastritis in Japan, China, Tanzania, and the Dominican Republic. (16118004)
2005
22
Invasive and non-invasive diagnosis of Helicobacter pylori-associated atrophic gastritis: a comparative study. (15932170)
2005
23
Atrophic gastritis in young children and adolescents. (16254110)
2005
24
Prof. Shan Zhaowei's experience in treating atrophic gastritis. (16334728)
2005
25
Serum pepsinogens as a predicator of the topography of intestinal metaplasia in patients with atrophic gastritis. (15259501)
2004
26
Long-term Helicobacter pylori infection and the development of atrophic gastritis and gastric cancer in Japan. (12109661)
2002
27
In diffuse atrophic gastritis, routine histology underestimates Helicobacter pylori infection. (12192199)
2002
28
Ethanol-derived microbial production of carcinogenic acetaldehyde in achlorhydric atrophic gastritis. (12126241)
2002
29
Double gastric infection with Helicobacter pylori and non-Helicobacter pylori bacteria during acid-suppressive therapy: increase of pro-inflammatory cytokines and development of atrophic gastritis. (11472319)
2001
30
B-cell monoclonality in Helicobacter pylori-associated chronic atrophic gastritis. (11315619)
2001
31
Chronic atrophic gastritis and gastric cancer. (11057931)
2000
32
Omeprazole and accelerated onset of atrophic gastritis. (10644182)
2000
33
Expression of bcl-2 in autoimmune and Helicobacter pylori-associated atrophic gastritis. (10219822)
1999
34
Atrophic gastritis during long-term omeprazole therapy affects serum vitamin B12 levels. (10540050)
1999
35
Positive result by serology indicates active Helicobacter pylori infection in patients with atrophic gastritis. (9620430)
1998
36
Gastric cancer and premalignant lesions in atrophic gastritis: a controlled trial on the effect of supplementation with alpha-tocopherol and beta-carotene. The Helsinki Gastritis Study Group. (9548624)
1998
37
Helicobacter pylori and the risk and management of associated diseases: gastritis, ulcer disease, atrophic gastritis and gastric cancer. (9146793)
1997
38
Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. (8598839)
1996
39
Immunogenetic analysis of the human leukocyte antigen DQA1 locus in patients with duodenal ulcer or chronic atrophic gastritis harbouring Helicobacter pylori. (8574742)
1995
40
Relationship between Helicobacter pylori infection, atrophic gastritis and gastric carcinoma in a Japanese population. (8574741)
1995
41
Comparative observations on the types of atrophic gastritis and biopsy pathology of gastric mucosa. (7877344)
1994
42
Relationship between Helicobacter pylori and atrophic gastritis. (7735942)
1994
43
Composite gastric carcinoma and precursor lesions with amphicrine features in chronic atrophic gastritis. (8381247)
1993
44
Morphology and pathogenesis of endocrine hyperplasias, precarcinoid lesions, and carcinoids arising in chronic atrophic gastritis. (2042031)
1991
45
Treatment of 910 cases of atrophic gastritis with wei you decoction. (2277511)
1990
46
Gastric emptying and gastrointestinal symptoms in patients with atrophic gastritis and the effects of domperidone. (2928739)
1989
47
Gastric carcinoids and atrophic gastritis. Evidence for an association. (6847375)
1983
48
Chronic atrophic gastritis. (6962533)
1982
49
Atrophic gastritis classification. (6819928)
1982
50
Gastric acid secretion in chronic atrophic gastritis and chronic (superficial) gastritis. (887004)
1977

Variations for Atrophic Gastritis

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Expression for genes affiliated with Atrophic Gastritis

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2BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atrophic Gastritis

Search GEO for disease gene expression data for Atrophic Gastritis.

Pathways for genes affiliated with Atrophic Gastritis

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50PathCards, 55Reactome, 38NCBI BioSystems Database, 30KEGG
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Pathways related to Atrophic Gastritis according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.6CDX2, GHRL
29.0FUT2, FUT3
3
Show member pathways
7.6NDUFS5, ADH7, ODC1, FUT2, FUT3

Compounds for genes affiliated with Atrophic Gastritis

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Sources:
45Novoseek, 61Tocris Bioscience, 29IUPHAR, 24HMDB, 11DrugBank, 51PharmGKB, 3BitterDB
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Compounds related to Atrophic Gastritis according to GeneCards/GeneDecks:

(show all 24)
idCompoundScoreTop Affiliating Genes
1oxyntomodulin45 6111.1GHRL, CHGA
2ranitidine45 29 24 1112.9CHGA, ADH7
3flutamide45 61 1111.9CHGA, ODC1
4octreotide45 61 29 1112.9GHRL, CHGA
5omeprazole45 51 29 24 1113.9CHGA, ADH7
6c-peptide459.8GHRL, CHGA
7famotidine45 3 24 1112.8GHRL, ADH7
8amide459.7CHGA, GHRL
9vitamin d459.6CHGA, GHRL, CDX2
10gnrh459.6GHRL, CHGA, ODC1
11ribonucleic acid459.6ODC1, CHGA, GHRL
12fatty acid459.5CHGA, GHRL, CDX2
13histamine45 29 2411.5ODC1, CHGA, GHRL
14lactate459.4GHRL, CHGA, ODC1
15dopamine45 29 24 1112.4GHRL, CHGA, ODC1
16GDP-L-fucose249.4FUT2, FUT3
17carbohydrates459.3FUT2, ODC1, GHRL
18thymidine45 2410.3ODC1, GHRL, CDX2
19adenylate459.2GHRL, CHGA, ODC1
20paraffin459.1CDX2, GHRL, CHGA, ODC1
21estrogen459.1CDX2, GHRL, CHGA, ODC1
22testosterone45 61 24 1111.9GHRL, CHGA, ODC1
23tyrosine458.8CDX2, GHRL, CHGA, ODC1
24cysteine458.6CDX2, CHGA, ODC1, FUT3

GO Terms for genes affiliated with Atrophic Gastritis

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16Gene Ontology
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Cellular components related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1Golgi cisterna membraneGO:0325809.0FUT2, FUT3

Biological processes related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1protein glycosylationGO:0064869.0FUT2, FUT3
2fucosylationGO:0360658.7FUT2, FUT3

Molecular functions related to Atrophic Gastritis according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1fucosyltransferase activityGO:0084179.0FUT2, FUT3

Products for genes affiliated with Atrophic Gastritis

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Sources for Atrophic Gastritis

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4CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
59SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet