OZENA
MCID: ATR003
MIFTS: 31

Atrophic Rhinitis (OZENA) malady

Categories: Respiratory diseases

Aliases & Classifications for Atrophic Rhinitis

Aliases & Descriptions for Atrophic Rhinitis:

Name: Atrophic Rhinitis 12 14
Rhinitis, Atrophic 12 42 69
Rhinitis Sicca 12 69
Ozena 12 69
Dry Rhinitis 12
Ozaena 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4731
MeSH 42 D012222
SNOMED-CT 64 28111002
UMLS 69 C0035459

Summaries for Atrophic Rhinitis

Disease Ontology : 12 A rhinitis which involves inflammation of the nose characterised by atrophy of nasal mucosa including the glands, turbinate bones, and the nerve elements supplying the nose that is caused by heredity factors, endocrine imbalance, nutritional deficiency, bacterial infection and autoimmune issues.

MalaCards based summary : Atrophic Rhinitis, also known as rhinitis, atrophic, is related to rhinitis and actinobacillosis, and has symptoms including rhinorrhea An important gene associated with Atrophic Rhinitis is XPNPEP2 (X-Prolyl Aminopeptidase 2), and among its related pathways/superpathways is MHC class II antigen presentation. The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include bone, testes and liver.

Related Diseases for Atrophic Rhinitis

Diseases related to Atrophic Rhinitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
id Related Disease Score Top Affiliating Genes
1 rhinitis 11.0
2 actinobacillosis 11.0
3 pneumonia 10.4
4 ectodermal dysplasia 10.1
5 pleuropneumonia 10.0
6 mucositis 9.9
7 leprosy 9.7
8 osteoporosis 9.7
9 nasopharyngitis 9.7
10 lepromatous leprosy 9.7
11 brucellosis 9.7
12 myiasis 9.7
13 diphtheria 9.7
14 typhoid fever 9.7
15 hypothyroidism 9.7
16 tuberculosis 9.7
17 vasomotor rhinitis 9.7
18 thyroiditis 9.7
19 dacryocystitis 9.7
20 middle cranial fossa meningioma 8.8 CD2AP CTSA EXT1 GUF1 IFI30 RPA1

Graphical network of the top 20 diseases related to Atrophic Rhinitis:



Diseases related to Atrophic Rhinitis

Symptoms & Phenotypes for Atrophic Rhinitis

UMLS symptoms related to Atrophic Rhinitis:


rhinorrhea

Drugs & Therapeutics for Atrophic Rhinitis

Drugs for Atrophic Rhinitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 1, Phase 2 51-84-3 187
2 abobotulinumtoxinA Phase 1, Phase 2
3 Botulinum Toxins Phase 1, Phase 2
4 Botulinum Toxins, Type A Phase 1, Phase 2
5 Cholinergic Agents Phase 1, Phase 2
6 incobotulinumtoxinA Phase 1, Phase 2
7 Neuromuscular Agents Phase 1, Phase 2
8 Neurotransmitter Agents Phase 1, Phase 2
9 onabotulinumtoxinA Phase 1, Phase 2
10 Peripheral Nervous System Agents Phase 1, Phase 2

Interventional clinical trials:


id Name Status NCT ID Phase
1 Benefits of the Use of Botox in the Treatment of Empty Nose Syndrome Syndrome Terminated NCT00732680 Phase 1, Phase 2
2 Study to Compare Resection Versus Preservation of the Middle Turbinate in Surgery for Nasal Polyps Recruiting NCT02855931
3 A Clinical Study to Evaluate the Safety and Efficacy of Platelet Rich Plasma Injection for Atrophic Rhinitis Not yet recruiting NCT03112330
4 Gore Tex Implants in the Treatment of Atrophic Rhinitis Suspended NCT00832403
5 Topical Antibiotic Use In Chronic Rhinosinusitis A Double-Blinded, Randomized, Placebo Controlled Study Withdrawn NCT00669799

Search NIH Clinical Center for Atrophic Rhinitis

Cochrane evidence based reviews: rhinitis, atrophic

Genetic Tests for Atrophic Rhinitis

Anatomical Context for Atrophic Rhinitis

MalaCards organs/tissues related to Atrophic Rhinitis:

39
Bone, Testes, Liver, Colon, Thyroid

Publications for Atrophic Rhinitis

Articles related to Atrophic Rhinitis:

(show top 50) (show all 371)
id Title Authors Year
1
Empty nose syndrome and atrophic rhinitis. ( 27613452 )
2016
2
Atrophic rhinitis caused by Cedecea davisae with accompanying mucocele. ( 26211869 )
2015
3
Surfactant protein a expression in chronic rhinosinusitis and atrophic rhinitis. ( 25992168 )
2015
4
Immunologic study and optimization of Salmonella delivery strains expressing adhesin and toxin antigens for protection against progressive atrophic rhinitis in a murine model. ( 25355999 )
2014
5
Generation of an attenuated Salmonella-delivery strains expressing adhesin and toxin antigens for progressive atrophic rhinitis, and evaluation of its immune responses in a murine model. ( 25045826 )
2014
6
Atrophic rhinitis presenting with ethmoidal mucocele: a case report. ( 25121010 )
2014
7
Complete Genome Sequence of Bordetella bronchiseptica S798, an Isolate from a Pig with Atrophic Rhinitis. ( 24831150 )
2014
8
New regenerative approach to atrophic rhinitis using autologous lipoaspirate transfer and platelet-rich plasma in five patients: Our Experience. ( 24938860 )
2014
9
Acute Exacerbation of Chronic Rhinosinusitis (AECRS) with Orbital Complications in an Atrophic Rhinitis Patient: A Mere Co-incidence? ( 24551696 )
2013
10
Chronic rhinosinusitis in ex-lepromatous leprosy patients with atrophic rhinitis. ( 23398842 )
2013
11
Atrophic rhinitis. ( 23484896 )
2013
12
Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin. ( 22411430 )
2012
13
Primary atrophic rhinitis: a clinical profile, microbiological and radiological study. ( 23762613 )
2012
14
Rhinoplasty in atrophic rhinitis. ( 23025225 )
2012
15
Interventions for atrophic rhinitis. ( 22336840 )
2012
16
Chemosensory function assessed with psychophysical testing and event-related potentials in patients with atrophic rhinitis. ( 21717190 )
2012
17
Anhidrotic ectodermal dysplasia presenting as atrophic rhinitis. ( 22666945 )
2011
18
Use of computer snout morphometry in atrophic rhinitis monitoring. ( 21498219 )
2011
19
Study of histopathological changes in primary atrophic rhinitis. ( 23724252 )
2011
20
A new technique for nasal stent fabrication for atrophic rhinitis: a clinical report. ( 21585589 )
2011
21
Rhinitis sicca, dry nose and atrophic rhinitis: a review of the literature. ( 20878413 )
2011
22
A report on a rare case of Klebsiella ozaenae causing atrophic rhinitis in the UK. ( 22669526 )
2011
23
Primary atrophic rhinitis. ( 20869578 )
2010
24
Microbiological study of role of fungi in primary atrophic rhinitis. ( 18926001 )
2009
25
Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine. ( 19428902 )
2009
26
Hypohidrotic ectodermal dysplasia with atrophic rhinitis and nasal myiasis. ( 19616858 )
2009
27
Novel treatment of atrophic rhinitis: early results. ( 18317788 )
2008
28
Chitosan microspheres containing Bordetella bronchiseptica antigens as novel vaccine against atrophic rhinitis in pigs. ( 18600065 )
2008
29
Prosthetic management of atrophic rhinitis. ( 23120587 )
2008
30
Atrophic rhinitis vaccine composition triggers different serological profiles that do not correlate with protection. ( 18401954 )
2008
31
On the risk of carcinomatous change in atrophic rhinitis. ( 17156518 )
2007
32
Atrophic rhinitis: a CFD study of air conditioning in the nasal cavity. ( 17569762 )
2007
33
Rhinoplasty and young's operation in atrophic rhinitis. ( 23120345 )
2006
34
Immunogenicity and efficacy of three recombinant subunit Pasteurella multocida toxin vaccines against progressive atrophic rhinitis in pigs. ( 16122849 )
2006
35
Light and electron microscopic study of primary atrophic rhinitis mucosa. ( 17063751 )
2006
36
Interesting observations on Primary Atrophic Rhinitis. ( 23120308 )
2006
37
Atrophic rhinitis in a patient with anhidrotic ectodermal dysplasia. ( 16218520 )
2005
38
Radiology quiz case 4: primary atrophic rhinitis, or ozena. ( 16103316 )
2005
39
The aetiology and management of atrophic rhinitis. ( 16354334 )
2005
40
Pre-cancerous changes in the nasal mucosa of atrophic rhinitis: A preliminary report. ( 23120119 )
2005
41
Pre and post-treatment histopathological changes in atrophic rhinitis. ( 16761739 )
2005
42
Development of a genetically modified nontoxigenic Pasteurella multocida toxin as a candidate for use in vaccines against progressive atrophic rhinitis in pigs. ( 15691045 )
2005
43
Association of growth performance with atrophic rhinitis and pneumonia detected at slaughter in a conventional pig herd in Hungary. ( 16156124 )
2005
44
An experimental mouse model of progressive atrophic rhinitis of swine. ( 15504591 )
2004
45
Anhidrotic ectodermal dysplasia presenting as atrophic rhinitis. ( 15318965 )
2004
46
Endoscopic dacryocystorhinostomy in cases of dacryocystitis due to atrophic rhinitis. ( 15285859 )
2004
47
Atrophic rhinitis in sheep in Austria. ( 14979445 )
2004
48
Differentiation of Pasteurella multocida isolates from cases of atrophic rhinitis in pigs from Zimbabwe by RAPD and ribotyping. ( 15288934 )
2004
49
Anhidrotic ectodermal dysplasia presenting as atrophic rhinitis and maggots. ( 14660852 )
2003
50
Characterization and comparison of Pasteurella multocida strains associated with porcine pneumonia and atrophic rhinitis. ( 12488567 )
2003

Variations for Atrophic Rhinitis

Expression for Atrophic Rhinitis

Search GEO for disease gene expression data for Atrophic Rhinitis.

Pathways for Atrophic Rhinitis

Pathways related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

id Super pathways Score Top Affiliating Genes
1 10.64 CTSA IFI30

GO Terms for Atrophic Rhinitis

Cellular components related to Atrophic Rhinitis according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 lysosomal lumen GO:0043202 8.62 CTSA IFI30

Sources for Atrophic Rhinitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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