MCID: ATR008
MIFTS: 38

Atrophy of Prostate malady

Reproductive diseases category

Summaries for Atrophy of Prostate

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32MalaCards
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MalaCards: Atrophy of Prostate is related to prostatitis and hepatitis c. An important gene associated with Atrophy of Prostate is NKX3-1 (NK3 homeobox 1), and among its related pathways are Etoposide Pathway, Pharmacokinetics/Pharmacodynamics and Acetaminophen metabolism. The compounds h2o2 and fumarate have been mentioned in the context of this disorder. Affiliated tissues include prostate, and related mouse phenotypes are adipose tissue and endocrine/exocrine gland.

Aliases & Classifications for Atrophy of Prostate

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8Disease Ontology, 60UMLS, 56SNOMED-CT, 27ICD9CM, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

atrophy of prostate 8


External Ids:

Disease Ontology8 DOID:2301
ICD9CM27 602.2
SNOMED-CT56 29524003
ICD1025 N42.2

Related Diseases for Atrophy of Prostate

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17GeneCards, 18GeneDecks
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Diseases related to Atrophy of Prostate via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 61)
idRelated DiseaseScoreTop Affiliating Genes
1prostatitis10.0
2hepatitis c10.0AMACR
3wilms tumor10.0AMACR
4myeloid leukemia10.0CEBPB
5ductal carcinoma in situ10.0TP53
6laryngeal benign neoplasm10.0TP53
7ulcerative colitis10.0TP53
8neuroblastoma10.0TP53
9gallbladder cancer10.0TP53
10hepatitis b10.0CEBPB
11thyroid cancer10.0TP53
12leiomyosarcoma10.0TP53
13laryngeal squamous cell carcinoma10.0TP53
14stomach cancer10.0TP53
15pancreatitis10.0GSTP1
16papilloma10.0TP53
17hepatitis10.0AMACR
18obesity10.0AR
19astrocytoma10.0TP53
20infertility10.0AR
21male infertility10.0AR
22osteosarcoma10.0TP53
23sertoli cell tumor10.0AR
24multiple myeloma10.0TP53
25kidney cancer10.0TP53, AMACR
26endometriosis10.0PTGS2
27osteoarthritis10.0PTGS2
28melanoma10.0AMACR, TP53
29arthritis10.0PTGS2
30uterine carcinosarcoma10.0PTGS2
31prostate disease10.0AR, AMACR
32endometrial carcinoma10.0GSTP1, TP53
33prostatic hypertrophy10.0AR
34bladder transitional cell carcinoma10.0TP53, GSTP1
35prostate cancer10.0GSTP1, AR
36pleomorphic adenoma10.0AMACR, AR
37actinic keratosis10.0TP53
38pleurisy10.0PTGS2
39leukemia10.0GSTP1, TP53, CEBPB
40lung small cell carcinoma10.0GSTP1, TP53, AMACR
41sarcoma10.0GSTP1, TP53, AR
42esophageal cancer10.0GSTP1, TP53, PTGS2
43bladder carcinoma in situ10.0PTGS2, TP53, GSTP1
44transitional cell carcinoma10.0GSTP1, TP53, PTGS2
45gastritis10.0TP53, PTGS2
46non-small cell lung carcinoma10.0PTGS2, TP53, GSTP1
47pancreatic cancer10.0TP53, CEBPB, PTGS2
48squamous cell carcinoma of the head and neck10.0GSTP1, TP53, PTGS2
49familial adenomatous polyposis10.0GSTP1, TP53, PTGS2
50bladder carcinoma10.0GSTP1, TP53, PTGS2

Graphical network of the top 20 diseases related to Atrophy of Prostate:



Diseases related to atrophy of prostate

Clinical Features for Atrophy of Prostate

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Drugs & Therapeutics for Atrophy of Prostate

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Atrophy of Prostate

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Anatomical Context for Atrophy of Prostate

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32MalaCards
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MalaCards organs/tissues related to Atrophy of Prostate:

32
Prostate

Animal Models for Atrophy of Prostate or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Atrophy of Prostate:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053759.7CEBPB, AMACR
2MP:00053799.3TP53, CEBPB
3MP:00053898.5TP53, CEBPB, PTGS2, NKX3-1
4MP:00053708.0AMACR, AR, PTGS2, CEBPB, TP53
5MP:00107717.8AR, PTGS2, CEBPB, TP53, GSTP1
6MP:00020067.8GSTP1, AR, NKX3-1, PTGS2, CEBPB, TP53
7MP:00053907.3AR, NKX3-1, BTG2, PTGS2, CEBPB, TP53
8MP:00053787.3AMACR, AR, PTGS2, CEBPB, TP53, GSTP1

Publications for Atrophy of Prostate

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50PubMed
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Articles related to Atrophy of Prostate:

(show all 15)
idTitleAuthorsYear
1
A case of spinal and bulbar muscular atrophy with high-stage and high-Gleason Score prostate cancer responded to maximal androgen blockade therapy. (21940987)
2012
2
Gene expression profiles and differential cytoglobin expression in atrophy and adenocarcinoma of the prostate. (22025306)
2012
3
Role of the androgen receptor CAG repeat polymorphism in prostate cancer, and spinal and bulbar muscular atrophy. (21284948)
2011
4
Overexpression of ELAV-like protein HuR is associated with increased COX-2 expression in atrophy, high-grade prostatic intraepithelial neoplasia, and incidental prostate cancer in cystoprostatectomies. (18468781)
2009
5
Increased p53 immunoreactivity in proliferative inflammatory atrophy of prostate is related to focal acute inflammation. (19245591)
2009
6
Morphological transition of proliferative inflammatory atrophy to high-grade intraepithelial neoplasia and cancer in human prostate. (19507201)
2009
7
Mechanisms of prostate atrophy after glandular botulinum neurotoxin type a injection: an experimental study in the rat. (18649990)
2009
8
Increased expression of CCAAT/enhancer-binding protein beta in proliferative inflammatory atrophy of the prostate: relation with the expression of COX-2, the androgen receptor, and presence of focal chronic inflammation. (17570496)
2007
9
Alpha-methylacyl coenzyme A racemase immunoreactivity in partial atrophy of the prostate. (17074684)
2006
10
Prostatic atrophy: immunohistochemical study of hypoxia induced factors. (17160630)
2006
11
Utility of immunohistochemistry for alpha-methylacyl-CoA racemase in distinguishing atrophic prostate cancer from benign atrophy. (15492996)
2004
12
Hypermethylation of the human glutathione S-transferase-pi gene (GSTP1) CpG island is present in a subset of proliferative inflammatory atrophy lesions but not in normal or hyperplastic epithelium of the prostate: a detailed study using laser-capture microdissection. (12937133)
2003
13
Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. (11751373)
2001
14
Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. (10595928)
1999
15
Identification of genes associated with stromal hyperplasia and glandular atrophy of the prostate by mRNA differential display. (9828097)
1998

Genetic Variations for Atrophy of Prostate

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Expression for genes affiliated with Atrophy of Prostate

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atrophy of Prostate

Search GEO for disease gene expression data for Atrophy of Prostate.

Pathways for genes affiliated with Atrophy of Prostate

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Sources:
49PharmGKB, 37NCBI BioSystems Database, 4Cell Signaling Technology, 29KEGG, 51QIAGEN, 12EMD Millipore
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Compounds for genes affiliated with Atrophy of Prostate

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Sources:
44Novoseek, 11DrugBank, 49PharmGKB, 28IUPHAR, 59Tocris Bioscience, 2BitterDB, 24HMDB
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Compounds related to Atrophy of Prostate according to GeneCards/GeneDecks:

(show all 45)
idCompoundScoreTop Affiliating Genes
1h2o24410.4AR
2fumarate44 1111.1GSTP1, AMACR
3sodium bisulfite4410.0AR, GSTP1
4drospirenone44 49 28 1112.9AR, PTGS2
5exemestane49 44 59 1112.9AR, PTGS2
6bpde449.8TP53, GSTP1
7chlorambucil44 1110.8TP53, GSTP1
83,3-diindolylmethane449.8AR, TP53
9olomoucine44 1110.7TP53, AR
10fluorouracil49 1110.7TP53, GSTP1
11o6-methylguanine449.7GSTP1, TP53
12gsno449.7GSTP1, CEBPB
13bcnu449.7GSTP1, TP53
14radicicol44 59 1111.7TP53, AR
15sulindac sulfide449.6TP53, PTGS2
16triptolide449.6PTGS2, TP53
17flufenamic acid44 28 2 1112.6PTGS2, AR
18parthenolide44 210.6TP53, PTGS2
19sulforaphane449.5GSTP1, PTGS2
20indole-3-carbinol449.5AR, TP53
21sulindac44 1110.4TP53, PTGS2
22docetaxel44 49 59 1112.4GSTP1, TP53, AR
235-aza-2deoxycytidine449.4GSTP1, TP53, AR
24guanine44 11 2411.4TP53, AR, AMACR
25aspirin44 49 28 2412.4GSTP1, CEBPB, PTGS2
26topotecan44 1110.3TP53, GSTP1
27irinotecan44 49 1111.3GSTP1, TP53, PTGS2
28vitamin d449.3CEBPB, AR, AMACR
29mg 13244 5910.3AR, CEBPB, TP53
30adenylate449.1GSTP1, CEBPB, AR, AMACR
31paraffin449.0AMACR, AR, TP53, GSTP1
32doxorubicin44 49 1111.0GSTP1, TP53, AR
33genistein44 28 59 2 11 2414.0GSTP1, CEBPB, PTGS2, AR
34retinoid449.0AR, NKX3-1, CEBPB, TP53
35dexamethasone44 49 28 1111.9AMACR, AR, PTGS2, CEBPB
36curcumin448.9AR, PTGS2, TP53, GSTP1
37etoposide44 49 59 1111.9AR, PTGS2, TP53, GSTP1
38testosterone44 59 11 2411.8AMACR, AR, NKX3-1, CEBPB, GSTP1
39vegf448.8GSTP1, TP53, PTGS2, AR
40progesterone44 59 28 11 2412.6TP53, CEBPB, NKX3-1, AR, AMACR
41ly294002448.6TP53, PTGS2, AR
42oligonucleotide448.5AMACR, BTG2, CEBPB, TP53
43n acetylcysteine448.4GSTP1, TP53, CEBPB, PTGS2, AR
44actinomycin d448.4AR, PTGS2, CEBPB, TP53, GSTP1
45retinoic acid44 249.2AMACR, AR, NKX3-1, CEBPB, TP53, GSTP1

GO Terms for genes affiliated with Atrophy of Prostate

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16Gene Ontology
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Cellular components related to Atrophy of Prostate according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1nuclear chromatinGO:0007909.7CEBPB
2protein complexGO:0432348.9TP53, PTGS2, AR

Biological processes related to Atrophy of Prostate according to GeneCards/GeneDecks:

(show all 13)
idNameGO IDScoreTop Affiliating Genes
1negative regulation of extrinsic apoptotic signaling pathwayGO:20012379.8GSTP1, AR
2mitotic cell cycle arrestGO:0718509.7NKX3-1, TP53
3negative regulation of epithelial cell proliferationGO:0506809.7NKX3-1, AR
4positive regulation of intrinsic apoptotic signaling pathwayGO:20012449.7TP53, NKX3-1
5negative regulation of fibroblast proliferationGO:0481479.6TP53, GSTP1
6androgen receptor signaling pathwayGO:0305219.6NKX3-1, AR
7brown fat cell differentiationGO:0508739.5CEBPB, PTGS2
8somitogenesisGO:0017569.5NKX3-1, TP53
9cellular response to UVGO:0346449.4TP53, PTGS2
10cellular response to hypoxiaGO:0714569.3TP53, PTGS2, NKX3-1
11cellular response to drugGO:0356909.2TP53, NKX3-1
12negative regulation of cell proliferationGO:0082858.4TP53, PTGS2, BTG2, NKX3-1
13negative regulation of apoptotic processGO:0430668.3GSTP1, TP53, CEBPB, BTG2

Molecular functions related to Atrophy of Prostate according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1androgen receptor activityGO:0048829.8NKX3-1, AR
2RNA polymerase II transcription factor bindingGO:0010859.1AR, TP53
3transcription regulatory region DNA bindingGO:0442129.1AR, NKX3-1, TP53
4enzyme bindingGO:0198998.8TP53, PTGS2, AR
5transcription factor bindingGO:0081348.6AR, NKX3-1, CEBPB, TP53
6RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positiveGO:0010778.6TP53, CEBPB, BTG2
7sequence-specific DNA binding transcription factor activityGO:0037008.5TP53, CEBPB, NKX3-1, AR

Products for genes affiliated with Atrophy of Prostate

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Sources for Atrophy of Prostate

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet