ADHD
MCID: ATT002
MIFTS: 75

Attention Deficit Hyperactivity Disorder (ADHD) malady

Mental diseases, Fetal diseases categories
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Summaries for Attention Deficit Hyperactivity Disorder

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NINDS:43 Attention deficit-hyperactivity disorder (ADHD) is a neurobehavioral disorder that affects 3-5 percent of all American children. It interferes with a person's ability to stay on a task and to exercise age-appropriate inhibition (cognitive alone or both cognitive and behavioral). Some of the warning signs of ADHD include failure to listen to instructions, inability to organize oneself and school work, fidgeting with hands and feet, talking too much, leaving projects, chores and homework unfinished, and having trouble paying attention to and responding to details. There are several types of ADHD: a predominantly inattentive subtype, a predominantly hyperactive-impulsive subtype, and a combined subtype. ADHD is usually diagnosed in childhood, although the condition can continue into the adult years.

MalaCards based summary: Attention Deficit Hyperactivity Disorder, also known as attention deficit disorder, is related to oppositional defiant disorder and conduct disorder, and has symptoms including An important gene associated with Attention Deficit Hyperactivity Disorder is DRD4 (dopamine receptor D4), and among its related pathways are dopamine degradation and Serotonin clearance from the synaptic cleft. The drugs selegiline and selegiline hydrochloride and the compounds fenoldopam and terguride have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotypes are integument and cardiovascular system.

Disease Ontology:8 A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age.

MedlinePlus:33 Is it hard for your child to sit still? does your child act without thinking first? does your child start but not finish things? if so, your child may have attention deficit hyperactivity disorder (adhd). nearly everyone shows some of these behaviors at times, but adhd lasts more than 6 months and causes problems in school, at home and in social situations. adhd is more common in boys than girls. it affects 3-5 percent of all american children. the main features of adhd are inattention hyperactivity impulsivity no one knows exactly what causes adhd. it sometimes runs in families, so genetics may be a factor. there may also be environmental factors. a complete evaluation by a trained professional is the only way to know for sure if your child has adhd. treatment may include medicine to control symptoms, therapy, or both. structure at home and at school is important. parent training may also help. nih: national institute of mental health

Wikipedia:65 Attention deficit hyperactivity disorder (ADHD, similar to hyperkinetic disorder in the ICD-10) is a... more...

Description from OMIM:46 143465

Aliases & Classifications for Attention Deficit Hyperactivity Disorder

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Sources:
32MalaCards, 8Disease Ontology, 10DISEASES, 33MedlinePlus, 62UMLS, 43NINDS, 44Novoseek, 9diseasecard, 22GTR, 46OMIM, 39NCIt, 57SNOMED-CT, 34MeSH, 25ICD10
See all sources

Attention Deficit Hyperactivity Disorder, Aliases & Descriptions:

Name: Attention Deficit Hyperactivity Disorder 32 8 10 33 62
Attention Deficit Disorder 8 44 62
Attention Deficit-Hyperactivity Disorder, Susceptibility to 9 22
Attention Deficit-Hyperactivity Disorder 43 46
 
Adhd 32 43
Attention-Deficit Hyperactivity Disorder 44
Hyperkinesis 8


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases
Anatomical: Mental diseases


External Ids:

Disease Ontology8 DOID:1094
NCIt39 C35092
SNOMED-CT57 23148009
MeSH34 D001289
ICD1025 F90.0

Related Diseases for Attention Deficit Hyperactivity Disorder

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Diseases related to Attention Deficit Hyperactivity Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 169)
idRelated DiseaseScoreTop Affiliating Genes
1oppositional defiant disorder32.1DRD4, SLC6A3, SLC6A2
2conduct disorder32.0DBH, SLC6A3, DRD5, DRD4, MAOA, COMT
3anxiety disorder31.7MAOA, TPH2
4personality disorder31.6HTR1B, SLC6A3, DRD4, TPH2, MAOA
5borderline personality disorder31.5HTR1B, MAOA
6nicotine dependence31.5CHRNA4, DRD4
7cocaine abuse31.4DBH, SLC6A3
8cocaine dependence31.4DBH, SLC6A3
9obesity31.4SLC6A2, ADRA2A, COMT, MAOA, DRD4, SLC6A3
10substance dependence31.4COMT, DRD4, DRD5, SLC6A3
11generalized anxiety disorder31.3SLC6A2, MAOA
12alcohol dependence31.3DRD1, HTR1B, MAOA, DRD4
13antisocial personality disorder31.3MAOA, HTR1B, SLC6A3
14substance abuse31.2DRD4, SLC6A3
15bulimia nervosa31.2MAOA, HTR1B, COMT
16bipolar disorder31.2DRD5, DRD1, SLC6A3, SLC6A2, MAOA, COMT
17autonomic dysfunction31.1DBH, SLC6A2
18drug dependence31.0SLC6A3, MAOA
19gilles de la tourette syndrome31.0SLC6A3, DRD5, DRD4, ADRA2A
20obsessive-compulsive disorder31.0HTR1B, COMT, MAOA, DRD4, DRD1, SLC6A3
21schizophrenia30.8TPH2, DBH, SLC6A2, SLC6A3, DRD1, DRD5
22panic disorder30.8TPH2, COMT, DRD4, SLC6A2, MAOA
23parkinson's disease30.7SLC6A3, COMT, MAOA, DBH, CHRNA4
24social phobia30.7MAOA, COMT
25alcohol abuse30.7SLC6A3, COMT
26mood disorder30.6ADRA2A, HTR1B, COMT, MAOA, DRD4, DRD1
27pathological gambling30.5DRD4, DRD1, SLC6A3
28autism spectrum disorder11.0
29tic disorder11.0
30developmental coordination disorder10.9
31pervasive developmental disorder10.9
32blindness10.9
33learning disability10.8
34autistic disorder10.7
35hypertension10.7
36dyslexia10.7
37restless legs syndrome10.7
38dysthymic disorder10.7
39cerebritis10.7
40fetal alcohol spectrum disorder10.7
41reading disorder10.7
42childhood-onset schizophrenia10.6
43mental retardation10.6
44bipolar i disorder10.6
45eating disorder10.6
46orthostatic intolerance10.5SLC6A2
47striatonigral degeneration10.5SLC6A3
48heroin dependence10.5DRD4
49major depressive disorder10.5
50velocardiofacial syndrome10.5

Graphical network of the top 20 diseases related to Attention Deficit Hyperactivity Disorder:



Diseases related to attention deficit hyperactivity disorder

Symptoms for Attention Deficit Hyperactivity Disorder

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Symptoms by clinical synopsis from OMIM:

143465

Clinical features from OMIM:

143465

HPO human phenotypes related to Attention Deficit Hyperactivity Disorder:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hyperactivity HP:0000752
3 attention deficit hyperactivity disorder HP:0007018

Drugs & Therapeutics for Attention Deficit Hyperactivity Disorder

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Genetic Tests for Attention Deficit Hyperactivity Disorder

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Genetic tests related to Attention Deficit Hyperactivity Disorder:

id Genetic test Affiliating Genes
1 Attention Deficit-Hyperactivity Disorder22

Anatomical Context for Attention Deficit Hyperactivity Disorder

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MalaCards organs/tissues related to Attention Deficit Hyperactivity Disorder:

32
Brain, Testes, Eye, Heart, Thyroid, Cortex, Prefrontal cortex, Cingulate cortex, Amygdala

Animal Models for Attention Deficit Hyperactivity Disorder or affiliated genes

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MGI Mouse Phenotypes related to Attention Deficit Hyperactivity Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107719.2TPH2, CHRNA4, DRD1, SLC6A3, SLC6A2, DBH
2MP:00053858.3DBH, TPH2, ADRA2A, ADRA2C, HTR1B, COMT
3MP:00053767.9ADRA2C, ADRA2A, TPH2, DBH, CHRNA4, COMT
4MP:00053867.9SLC6A2, DBH, TPH2, ADRA2A, ADRA2C, CHRNA4
5MP:00036317.9CHRNA4, ADRA2C, ADRA2A, TPH2, DBH, DOCK3

Publications for Attention Deficit Hyperactivity Disorder

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Articles related to Attention Deficit Hyperactivity Disorder:

(show top 50)    (show all 1153)
idTitleAuthorsYear
1
Cerebellar morphology and the effects of stimulant medications in youths with attention deficit-hyperactivity disorder. (24077064)
2014
2
Reading outcomes of children and adolescents with attention-deficit/hyperactivity disorder and dyslexia following atomoxetine treatment. (25299355)
2014
3
Neurofeedback in attention-deficit/hyperactivity disorder - different models, different ways of application. (25374528)
2014
4
Does diagnosis affect the predictive accuracy of risk assessment tools for juvenile offenders: Conduct Disorder and Attention Deficit Hyperactivity Disorder. (25173178)
2014
5
Diminished testing benefits in young adults with attention-deficit hyperactivity disorder. (25385006)
2014
6
Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. (25056274)
2014
7
Nicotinic attention-deficit/hyperactivity disorder treatment. (24370349)
2014
8
Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. (23461725)
2013
9
Objective measurement of weekly physical activity and sensory modulation problems in children with attention deficit hyperactivity disorder. (23927990)
2013
10
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
11
Attention deficit hyperactivity disorder in cocaine-dependent adults: a psychiatric comorbidity analysis. (23952892)
2013
12
Adult attention deficit hyperactivity disorder symptoms and five-factor model traits in a clinical sample: a structural equation modeling approach. (24080671)
2013
13
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
14
Subthreshold attention-deficit/hyperactivity disorder is associated with functional impairments across domains: a comprehensive analysis in a large-scale community study. (24318039)
2013
15
EEG brain mapping and brain connectivity index for subtypes classification of attention deficit hyperactivity disorder children during the eye-opened period. (24111455)
2013
16
Attention-deficit/hyperactivity disorder, physical health, and lifestyle in older adults. (23711084)
2013
17
Early-age clinical and developmental features associated to Substance Use Disorders in Attention-Deficit/Hyperactivity Disorder in Adults. (24411652)
2013
18
The merit of sociological accounts of disorder: The Attention-Deficit Hyperactivity Disorder case. (24287297)
2013
19
Reply to: Attention-Deficit/Hyperactivity Disorder and Solar Irradiance: A Cloudy Perspective. (24252358)
2013
20
Fatty acid correlates of temperament in adolescent boys with attention deficit hyperactivity disorder. (23566869)
2013
21
Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder. (23734235)
2013
22
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis. (23735885)
2013
23
Drugs for attention deficit-hyperactivity disorder do not increase the mid-term risk of sudden death in children: a meta-analysis of observational studies. (23669111)
2013
24
Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. (21824190)
2012
25
Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items. (23267399)
2012
26
Parent-reported attention-deficit hyperactivity disorder and subtypes of conduct disorder as risk factor of recidivism in detained male adolescents. (21420836)
2012
27
Identification of attention-deficit-hyperactivity disorder and conduct disorder in Mexican children by the scale for evaluation of deficit of attention and hyperactivity. (20934222)
2011
28
Genome-wide association study in German patients with attention deficit/hyperactivity disorder. (22012869)
2011
29
Increased symptoms of attention deficit hyperactivity disorder and major depressive disorder symptoms in Nail-patella syndrome: potential association with LMX1B loss-of-function. (21184584)
2011
30
Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. (20732625)
2010
31
DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. (20736997)
2010
32
Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression. (20862695)
2010
33
Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms. (20943059)
2010
34
Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. (19150055)
2009
35
Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (18428117)
2008
36
A case-control association study of the polymorphism at the promoter region of the DRD4 gene in Korean boys with attention deficit-hyperactivity disorder: evidence of association with the -521 C/T SNP. (17850946)
2008
37
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. (18413706)
2008
38
Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder. (17466583)
2007
39
Analysis of the dopamine D4 receptor gene variants in attention deficit hyperactivity disorder]. (17879560)
2007
40
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. (16854470)
2006
41
The dopamine transporter gene and the impulsivity phenotype in attention deficit hyperactivity disorder: a case-control association study in a Korean sample. (16368111)
2006
42
Candidate gene studies of attention-deficit/hyperactivity disorder. (16961425)
2006
43
A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms. (16616730)
2006
44
Attention-deficit/hyperactivity disorder (ADHD) and variable clinical expression of Aarskog-Scott syndrome due to a novel FGD1 gene mutation (R408Q). (15809997)
2005
45
Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. (16380908)
2005
46
Meta-analysis of candidate genes in attention-deficit hyperactivity disorder]. (16389711)
2005
47
Association between dopamine beta hydroxylase gene and attention deficit hyperactivity disorder complicated with disruptive behavior disorder]. (15796803)
2005
48
Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (16178932)
2005
49
Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children]. (15205702)
2004
50
Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder. (10654661)
2000

Variations for Attention Deficit Hyperactivity Disorder

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Expression for genes affiliated with Attention Deficit Hyperactivity Disorder

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Expression patterns in normal tissues for genes affiliated with Attention Deficit Hyperactivity Disorder

Search GEO for disease gene expression data for Attention Deficit Hyperactivity Disorder.

Pathways for genes affiliated with Attention Deficit Hyperactivity Disorder

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Pathways related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.0MAOA, COMT
2
Show member pathways
10.0COMT, MAOA
310.0MAOA, COMT
4
Show member pathways
Nicotine Activity on Dopaminergic Neurons37
9.9DRD4, CHRNA4, DRD1
5
Show member pathways
9.9MAOA, DRD1, SLC6A3
69.8MAOA, TPH2, HTR1B
79.8TPH2, CHRNA4, MAOA
89.8MAOA, COMT, DBH
9
Show member pathways
phenylalanine utilization37
noradrenaline and adrenaline degradation37
phenylalanine degradation IV37
9.8MAOA, COMT, DBH
10
Show member pathways
catecholamine biosynthesis37
9.8MAOA, DBH, COMT
119.6ADRA2C, SLC6A2, ADRA2A, DBH
12
Show member pathways
9.6MAOA, COMT, CHRNA4, SLC6A3
13
Show member pathways
Serotonin Transporter Activity37
9.5SLC6A2, SLC6A3, MAOA, DBH, TPH2
14
Show member pathways
9.4DRD4, DRD1, DRD5, HTR1B, ADRA2C, ADRA2A
15
Show member pathways
9.1DRD5, DRD4, HTR1B, CHRNA4, DRD1, ADRA2C
16
Show member pathways
8.7CHRNA4, TPH2, HTR1B, COMT, MAOA, DRD4

Compounds for genes affiliated with Attention Deficit Hyperactivity Disorder

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Compounds related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 206)
idCompoundScoreTop Affiliating Genes
1fenoldopam44 1111.0DRD1, DRD5, ADRA2C, ADRA2A
2terguride44 2811.0DRD4, ADRA2A, ADRA2C, HTR1B
3pseudoephedrine44 24 1112.0ADRA2A, SLC6A2, SLC6A3, MAOA
4d amphetamine4410.0SLC6A3, MAOA, DRD1, SLC6A2
5nefazodone44 50 1112.0SLC6A2, SLC6A3, HTR1B, ADRA2A
6paliperidone44 1110.9ADRA2A, DRD1, DRD4, ADRA2C
7chlorpromazine28 44 50 1112.9ADRA2A, DRD4, ADRA2C, DRD1, DRD5
8asenapine28 1110.9ADRA2A, HTR1B, DRD4, ADRA2C, DRD1
9p-chloroamphetamine449.9MAOA, SLC6A3, SLC6A2
10venlafaxine44 50 24 1112.8SLC6A2, COMT, HTR1B, SLC6A3, TPH2
11dopac449.8COMT, DBH, MAOA, DRD1
12clomipramine44 50 1111.8MAOA, SLC6A2, SLC6A3, HTR1B
13amphetamine44 50 1111.8MAOA, SLC6A3, DRD1, SLC6A2, DRD4
14fluvoxamine44 50 1111.8COMT, SLC6A3, MAOA, SLC6A2
15mhpg449.8DRD4, MAOA, DBH, SLC6A2, COMT
16lisuride44 28 1111.8DRD5, HTR1B, ADRA2C, ADRA2A, DRD4, DRD1
17homovanillic acid44 2410.8MAOA, SLC6A2, COMT, DBH
18fluoxetine44 50 28 1112.8SLC6A3, MAOA, HTR1B, SLC6A2, TPH2
19aripiprazole28 44 50 24 1113.8HTR1B, ADRA2A, DRD4, DRD5, DRD1, ADRA2C
20ziprasidone28 50 44 1112.8ADRA2A, DRD1, DRD5, DRD4, HTR1B, ADRA2C
21imipramine44 28 50 24 1113.7DRD1, SLC6A3, DBH, MAOA, SLC6A2
22paroxetine44 50 28 1112.7HTR1B, COMT, MAOA, DRD4, SLC6A3, SLC6A2
23quetiapine44 50 28 24 1113.6SLC6A3, ADRA2A, DRD1, DRD5, DRD4, ADRA2C
24tyramine44 28 2411.6MAOA, COMT, ADRA2A, SLC6A2, SLC6A3, DBH
25cabergoline44 28 1111.6DRD1, DRD5, DRD4, COMT, HTR1B, ADRA2C
26ropinirole44 1110.6ADRA2C, HTR1B, COMT, DRD4, DRD5, DRD1
27pergolide44 28 1111.6DRD1, DRD5, ADRA2A, ADRA2C, HTR1B, COMT
28mptp449.5DBH, DRD1, MAOA, SLC6A2, SLC6A3, COMT
29haloperidol44 50 28 2 1113.5SLC6A3, DRD4, DRD1, SLC6A2, DRD5
30risperidone44 50 28 61 24 1114.5COMT, SLC6A3, DRD4, DRD1, HTR1B, ADRA2C
31cocaine44 1110.5HTR1B, DBH, COMT, DRD4, DRD1, SLC6A3
326-hydroxydopamine449.5MAOA, DBH, COMT, DRD4, DRD1, SLC6A3
33apomorphine28 44 1111.4DRD5, DRD1, SLC6A3, DRD4, COMT, ADRA2A
34amine449.4SLC6A2, HTR1B, COMT, MAOA, DBH
35olanzapine44 50 28 24 1113.4ADRA2A, ADRA2C, HTR1B, COMT, DRD4, DRD5
36bromocriptine44 28 1111.4COMT, HTR1B, ADRA2C, ADRA2A, DRD4, DRD5
37pramipexole44 28 50 1112.4DRD4, ADRA2A, ADRA2C, HTR1B, SLC6A3, DRD1
38gaba449.4DBH, DRD1, SLC6A3, MAOA, SLC6A2, DRD4
39clozapine44 28 50 1112.4HTR1B, DRD4, DRD5, DRD1, SLC6A3, COMT
40methylphenidate44 50 1111.4ADRA2A, DRD4, SLC6A2, SLC6A3, DRD1, DRD5
41maoa449.3DRD4, MAOA, COMT, SLC6A2, SLC6A3, HTR1B
42levodopa44 1110.3SLC6A3, DRD1, DRD4, DRD5, MAOA, COMT
43methamphetamine44 50 1111.3ADRA2A, COMT, MAOA, DRD4, DRD1, ADRA2C
445-hydroxytryptamine449.3SLC6A2, SLC6A3, DRD4, COMT, HTR1B, TPH2
45epinephrine44 24 1111.2MAOA, SLC6A2, DRD4, COMT, ADRA2A, DBH
46nicotine44 28 50 1112.2DRD4, MAOA, COMT, CHRNA4, DBH, DRD1
47catecholamine449.1SLC6A2, DRD1, DRD5, DRD4, MAOA, COMT
48norepinephrine44 24 1110.9DBH, ADRA2A, SLC6A2, ADRA2C, SLC6A3, DRD1
49glutamate448.6DRD4, DRD1, SLC6A3, COMT, DBH, SLC6A2
50dopamine44 28 24 1111.5MAOA, COMT, HTR1B, CHRNA4, ADRA2C, ADRA2A

GO Terms for genes affiliated with Attention Deficit Hyperactivity Disorder

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Cellular components related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral component of plasma membraneGO:0058878.7ADRA2A, ADRA2C, HTR1B, DRD4, DRD5, DRD1
2plasma membraneGO:0058868.5ADRA2A, ADRA2C, CHRNA4, HTR1B, COMT, DRD4

Biological processes related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 42)
idNameGO IDScoreTop Affiliating Genes
1sensitizationGO:04696010.5DRD1, DRD5
2cellular response to catecholamine stimulusGO:07187010.5DRD5, DRD1
3dopamine transportGO:01587210.5SLC6A3, DRD1
4positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.5DRD5, DRD1
5monoamine transportGO:01584410.5SLC6A3, SLC6A2
6phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.5DRD5, DRD1
7negative regulation of uterine smooth muscle contractionGO:07047310.5ADRA2C, ADRA2A
8activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188310.5ADRA2A, ADRA2C
9epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.4ADRA2C, ADRA2A
10behavioral response to ethanolGO:04814910.4DBH, DRD4
11negative regulation of epinephrine secretionGO:03281110.4ADRA2A, ADRA2C
12regulation of inhibitory postsynaptic membrane potentialGO:06008010.4CHRNA4, DRD4
13synaptic transmission, dopaminergicGO:00196310.4DRD1, DRD5, DRD4
14dopamine metabolic processGO:04241710.4DRD4, DRD1
15negative regulation of norepinephrine secretionGO:01070010.4ADRA2A, ADRA2C
16regulation of dopamine metabolic processGO:04205310.4DRD4, DRD1, SLC6A3
17response to cocaineGO:04222010.4HTR1B, DRD5, SLC6A3
18adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.4DRD5, DRD1
19negative regulation of cAMP biosynthetic processGO:03081810.4DRD4, HTR1B, ADRA2A
20fear responseGO:04259610.4DRD4, ADRA2A, DBH
21positive regulation of potassium ion transportGO:04326810.4ADRA2A, DRD1
22behavioral response to cocaineGO:04814810.4DRD1, DRD4
23neurotransmitter catabolic processGO:04213510.3COMT, MAOA
24regulation of dopamine secretionGO:01405910.3CHRNA4, HTR1B
25long term synaptic depressionGO:06029210.3DRD1, DRD5
26prepulse inhibitionGO:06013410.3DRD1, SLC6A3
27maternal behaviorGO:04271110.3DRD1, DBH
28neurotransmitter biosynthetic processGO:04213610.2COMT, MAOA, SLC6A3
29response to painGO:04826510.2SLC6A2, COMT, DBH
30activation of protein kinase B activityGO:03214810.2ADRA2C, ADRA2A
31response to amphetamineGO:00197510.2DBH, DRD4, DRD5, DRD1
32transmission of nerve impulseGO:01922610.2DRD1, DRD5
33locomotory behaviorGO:00762610.2SLC6A3, CHRNA4, DBH
34female pregnancyGO:00756510.1COMT, ADRA2C, ADRA2A
35response to nicotineGO:03509410.0SLC6A3, CHRNA4
36behavioral fear responseGO:00166210.0DRD1, DRD4
37dopamine catabolic processGO:04242010.0SLC6A3, MAOA, COMT, DBH
38positive regulation of vasoconstrictionGO:04590710.0DBH, ADRA2C
39response to drugGO:04249310.0COMT, DRD1, SLC6A3, SLC6A2
40negative regulation of adenylate cyclase activityGO:0071949.9DRD4, ADRA2A
41synaptic transmissionGO:0072689.4DBH, CHRNA4, COMT, MAOA, DRD5, SLC6A3
42small molecule metabolic processGO:0442819.3DBH, TPH2, ADRA2A, ADRA2C, COMT, MAOA

Molecular functions related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.2DRD1, DRD5
2dopamine neurotransmitter receptor activityGO:00495210.1DRD4, DRD5, DRD1
3alpha2-adrenergic receptor activityGO:00493810.1ADRA2A, ADRA2C
4monoamine transmembrane transporter activityGO:00850410.0SLC6A2, SLC6A3
5drug bindingGO:00814410.0SLC6A3, DRD4, HTR1B
6dopamine bindingGO:03524010.0SLC6A3, DRD1, DRD5, DRD4
7epinephrine bindingGO:0513799.8ADRA2C, ADRA2A

Products for genes affiliated with Attention Deficit Hyperactivity Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Attention Deficit Hyperactivity Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet