ADHD
MCID: ATT002
MIFTS: 72

Attention Deficit Hyperactivity Disorder (ADHD) malady

Summaries for Attention Deficit Hyperactivity Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 3CDC, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
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NINDS:44 Attention deficit-hyperactivity disorder (ADHD) is a neurobehavioral disorder that affects 3-5 percent of all American children. It interferes with a person's ability to stay on a task and to exercise age-appropriate inhibition (cognitive alone or both cognitive and behavioral). Some of the warning signs of ADHD include failure to listen to instructions, inability to organize oneself and school work, fidgeting with hands and feet, talking too much, leaving projects, chores and homework unfinished, and having trouble paying attention to and responding to details. There are several types of ADHD: a predominantly inattentive subtype, a predominantly hyperactive-impulsive subtype, and a combined subtype. ADHD is usually diagnosed in childhood, although the condition can continue into the adult years.

MalaCards: Attention Deficit Hyperactivity Disorder, also known as attention deficit disorder, is related to conduct disorder and bipolar disorder. An important gene associated with Attention Deficit Hyperactivity Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Circadian entrainment and Monoamine GPCRs. The drugs amphetamine and clonidine and the compounds dopamine and norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and heart, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age.

MedlinePlus:34 Is it hard for your child to sit still? does your child act without thinking first? does your child start but not finish things? if so, your child may have attention deficit hyperactivity disorder (adhd). nearly everyone shows some of these behaviors at times, but adhd lasts more than 6 months and causes problems in school, at home and in social situations. adhd is more common in boys than girls. it affects 3-5 percent of all american children. the main features of adhd are inattention hyperactivity impulsivity no one knows exactly what causes adhd. it sometimes runs in families, so genetics may be a factor. there may also be environmental factors. a complete evaluation by a trained professional is the only way to know for sure if your child has adhd. treatment may include medicine to control symptoms, therapy, or both. structure at home and at school is important. parent training may also help. nih: national institute of mental health

CDC:3  

Wikipedia:64 Attention deficit hyperactivity disorder (ADHD, similar to hyperkinetic disorder in the ICD-10) is a... more...

Description from OMIM:47 143465

Aliases & Classifications for Attention Deficit Hyperactivity Disorder

Sources:
33MalaCards, 8Disease Ontology, 9diseasecard, 22GTR, 44NINDS, 47OMIM, 10DISEASES, 45Novoseek, 34MedlinePlus, 61UMLS, 35MeSH, 57SNOMED-CT, 40NCIt
See all sources

Aliases & Descriptions:

attention deficit hyperactivity disorder 33 8 10 34 61
attention deficit disorder 8 45 61
attention deficit-hyperactivity disorder, susceptibility to 9 22
attention deficit-hyperactivity disorder 44 47
adhd 33 44
attention-deficit hyperactivity disorder 45
hyperkinesis 8


External Ids:

Disease Ontology8 DOID:1094
MeSH35 D001289
SNOMED-CT57 23148009
NCIt40 C35092

Related Diseases for Attention Deficit Hyperactivity Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Attention Deficit Hyperactivity Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 153)
idRelated DiseaseScoreTop Affiliating Genes
1conduct disorder31.7COMT, DRD4, DRD5, MAOA, DBH, SLC6A3
2bipolar disorder31.3COMT, DRD1, DRD4, DRD5, MAOA, DBH
3anxiety disorder31.1COMT, MAOA, SLC6A3, SLC6A2, TPH2
4obsessive-compulsive disorder31.1COMT, HTR1B, DRD1, DRD4, MAOA, SLC6A3
5substance dependence31.0COMT, DRD4, DRD5, SLC6A3
6borderline personality disorder30.9MAOA, HTR1B
7alcohol dependence30.8HTR1B, DRD1, DRD4, MAOA
8substance abuse30.7DRD4, SLC6A3
9nicotine dependence30.7DRD4
10cocaine abuse30.7DBH, SLC6A3
11antisocial personality disorder30.6SLC6A3, MAOA, HTR1B
12bulimia nervosa30.6COMT, HTR1B, MAOA
13cocaine dependence30.6DBH, SLC6A3
14chronic fatigue syndrome30.6MAOA
15parkinson's disease30.4COMT, HTR1B, DRD1, DRD4, MAOA, DBH
16panic disorder30.4COMT, DRD4, MAOA, SLC6A2, TPH2
17gilles de la tourette syndrome30.4DRD4, DRD5, SLC6A3, ADRA2A
18alcohol abuse30.4SLC6A3, COMT
19generalized anxiety disorder30.4SLC6A2, MAOA
20social phobia30.0COMT, MAOA
21pathological gambling29.8DRD1, DRD4, SLC6A3
22autonomic dysfunction29.8DBH, SLC6A2
23autism spectrum disorder11.0
24sleep disorder10.9
25developmental coordination disorder10.9
26autistic disorder10.8
27n syndrome10.7
28dyslexia10.7
29dysthymic disorder10.7
30restless legs syndrome10.6
31bipolar i disorder10.6
32childhood-onset schizophrenia10.6
33mental retardation10.6
34seizure disorder10.6
35periodic limb movement disorder10.6
36tic disorder10.6
37major depressive disorder10.5
38velocardiofacial syndrome10.5
39neurofibromatosis10.4
40coloboma10.4
41asperger syndrome10.4
42chronic tic disorder10.4
43post-traumatic stress disorder10.4
44kleptomania10.4
45withdrawal disorder10.4
46writing disorder10.4
47williams syndrome10.4
48brain injury10.4
49febrile seizures10.4
50traumatic brain injury10.4

Graphical network of the top 20 diseases related to Attention Deficit Hyperactivity Disorder:



Diseases related to attention deficit hyperactivity disorder

Clinical Features for Attention Deficit Hyperactivity Disorder

Sources:
47OMIM
See all sources

Clinical features from OMIM:

143465

Clinical synopsis from OMIM:

143465

Drugs & Therapeutics for Attention Deficit Hyperactivity Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
See all sources

Genetic Tests for Attention Deficit Hyperactivity Disorder

Sources:
22GTR
See all sources

Genetic tests related to Attention Deficit Hyperactivity Disorder:

id Genetic test Affiliating Genes
1 Attention Deficit-hyperactivity Disorder22

Anatomical Context for Attention Deficit Hyperactivity Disorder

Sources:
33MalaCards
See all sources

MalaCards organs/tissues related to Attention Deficit Hyperactivity Disorder:

33
Brain, Cortex, Heart, Thyroid, Skin, T cells, B cells, Fetal brain, Prefrontal cortex, Cingulate cortex, Temporal lobe, Amygdala, Fetal thyroid

Animal Models for Attention Deficit Hyperactivity Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

MGI Mouse Phenotypes related to Attention Deficit Hyperactivity Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538611.3ADRA2C, SLC6A2, SLC6A3, DBH, MAOA, DOCK3
2MP:000363111.2SLC6A3, ADRA2C, SLC6A2, COMT, DRD1, DRD4
3MP:000537611.2DRD1, DRD4, MAOA, DBH, SLC6A3, SLC6A2
4MP:000538510.8DRD5, ADRA2C, ADRA2A, DBH, MAOA, DRD1

Publications for Attention Deficit Hyperactivity Disorder

Sources:
51PubMed
See all sources

Articles related to Attention Deficit Hyperactivity Disorder:

(show top 50)    (show all 1142)
idTitleAuthorsYear
1
A phenomenological case study of communication between clinicians about attention-deficit/hyperactivity disorder assessment. (23899584)
2014
2
Objective measurement of weekly physical activity and sensory modulation problems in children with attention deficit hyperactivity disorder. (23927990)
2013
3
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis. (23735885)
2013
4
Geographic variation in the prevalence of attention-deficit/hyperactivity disorder: the sunny perspective. (23523340)
2013
5
Changes in Behaviour Symptoms of Patients with Attention Deficit/Hyperactivity Disorder during Treatment: Observation from Different Informants. (23482303)
2013
6
A systematic review of combination therapy with stimulants and atomoxetine for attention-deficit/hyperactivity disorder, including patient characteristics, treatment strategies, effectiveness, and tolerability. (23560600)
2013
7
Randomized, Double-Blind, Placebo-Controlled, Crossover Study of the Effects of Lisdexamfetamine Dimesylate and Mixed Amphetamine Salts on Cognition Throughout the Day in Adults with Attention-Deficit/Hyperactivity Disorder. (24297663)
2013
8
Effects of neurofeedback versus stimulant medication in attention-deficit/hyperactivity disorder: a randomized pilot study. (23808786)
2013
9
Verbal fluency in adults diagnosed with attention-deficit hyperactivity disorder (ADHD) in childhood. (23749309)
2013
10
Asthma and attention-deficit/hyperactivity disorder: a nationwide population-based prospective cohort study. (23730913)
2013
11
Sleep lab adaptation in children with attention-deficit/hyperactivity disorder and typically developing children. (23766917)
2013
12
Genetic targeting of the amphetamine and methylphenidate-sensitive dopamine transporter: On the path to an animal model of attention-deficit hyperactivity disorder. (24332984)
2013
13
Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. (23533005)
2013
14
Transition to adult mental health services for young people with attention deficit/hyperactivity disorder (ADHD): a qualitative analysis of their experiences. (23497082)
2013
15
An observational study of response heterogeneity in children with attention deficit hyperactivity disorder following treatment switch to modified-release methylphenidate. (24004962)
2013
16
Psychotherapy for adult attention deficit/hyperactivity disorder: a comparison with cognitive behaviour therapy. (23506050)
2013
17
Potential trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: wastewater analysis of amphetamine and ritalinic acid. (23500822)
2013
18
Systematic review of clinical trials of aripiprazole for treating attention deficit hyperactivity disorder. (24141455)
2013
19
Source discrimination in adults with attention deficit hyperactivity disorder. (23741472)
2013
20
Attention-deficit/hyperactivity disorder increased the risk of injury: a population-based follow-up study. (23647526)
2013
21
Parent-reported sleep problems, symptom ratings, and serum ferritin levels in children with attention-deficit/hyperactivity disorder: a case control study. (24377840)
2013
22
Associations between attention deficit hyperactivity disorder symptom domains and DSM-IV lifetime substance dependence. (23398223)
2013
23
Correlates of Physical Activity with Intrusive Thoughts, Worry and Impulsivity in Adults with Attention Deficit/Hyperactivity Disorder: A Cross-sectional Pilot Study. (24029111)
2013
24
DCLK1 variants are associated across schizophrenia and attention deficit/hyperactivity disorder. (22539971)
2012
25
Chiropractic management of a patient with symptoms of attention-deficit/hyperactivity disorder. (23449647)
2012
26
Jordan-3: measuring visual reversals in children as symptoms of learning disability and attention-deficit/hyperactivity disorder. (23409590)
2012
27
Natural selection and the attention deficit hyperactivity disorder-obsessive compulsive personality disorder theory of human behavior. (22954719)
2012
28
Focal EEG abnormalities might reflect neuropathological characteristics of pervasive developmental disorder and attention-deficit/hyperactivity disorder. (22225922)
2012
29
Family-based genome-wide association scan of attention-deficit/hyperactivity disorder. (20732626)
2010
30
Attention-deficit/hyperactivity disorder phenotype is influenced by a functional catechol-O-methyltransferase variant. (19946713)
2010
31
Rare structural variants found in attention-deficit hyperactivity disorder are preferentially associated with neurodevelopmental genes. (19546859)
2010
32
A case-control association study of serotonin 1A receptor gene and tryptophan hydroxylase 2 gene in attention deficit hyperactivity disorder. (20470849)
2010
33
Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorder. (20410729)
2010
34
Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder. (18937294)
2008
35
Association between the alpha-2C-adrenergic receptor gene and attention deficit hyperactivity disorder in a Korean sample. (18835330)
2008
36
Association study of 10 genes encoding neurotrophic factors and their receptors in adult and child attention-deficit/hyperactivity disorder. (18179783)
2008
37
Functional gene variation in the human norepinephrine transporter: association with attention deficit hyperactivity disorder. (18591486)
2008
38
Clinical and genetic characteristics of Korean male alcoholics with and without attention deficit hyperactivity disorder. (16679343)
2006
39
Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. (16380908)
2005
40
Association between dopamine transporter (DAT1) genotype, left-sided inattention, and an enhanced response to methylphenidate in attention-deficit hyperactivity disorder. (16123773)
2005
41
Mutation screen of the brain derived neurotrophic factor gene (BDNF): identification of several genetic variants and association studies in patients with obesity, eating disorders, and attention-deficit/hyperactivity disorder. (15457498)
2005
42
Meta-analysis of family-based association studies between the dopamine transporter gene and attention deficit hyperactivity disorder. (15722958)
2005
43
Prevalence of bruxism in children receiving treatment for attention deficit hyperactivity disorder: a pilot study. (15554406)
2004
44
Efficacy and safety of atomoxetine in childhood attention-deficit/hyperactivity disorder with comorbid oppositional defiant disorder. (15801334)
2004
45
Association studies of dopamine D4 receptor gene and dopamine transporter gene polymorphisms in Han Chinese patients with attention deficit hyperactivity disorder]. (12947560)
2003
46
Models of drug treatment in the attention deficit disorder with hyperactivity]. (12447798)
2002
47
Linkage study of the alpha2A adrenergic receptor in attention-deficit hyperactivity disorder families. (11304829)
2001
48
Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. (11425009)
2001
49
Working memory in childhood-onset schizophrenia and attention-deficit/hyperactivity disorder. (9754696)
1998
50
Coexistence of childhood onset pervasive developmental disorder and attention deficit disorder with hyperactivity. (7468843)
1981

Genetic Variations for Attention Deficit Hyperactivity Disorder

Expression for genes affiliated with Attention Deficit Hyperactivity Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Attention Deficit Hyperactivity Disorder

Search GEO for disease gene expression data for Attention Deficit Hyperactivity Disorder.

Pathways for genes affiliated with Attention Deficit Hyperactivity Disorder

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 50PharmGKB, 12EMD Millipore
See all sources

Pathways related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 14)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
11.0COMT, HTR1B, DRD1, DRD4, DRD5, MAOA
2
Hide members
10.9ADRA2A, MAOA, DRD5, DRD4, DRD1, HTR1B
3
Hide members
10.8HTR1B, DRD1, DRD4, DRD5, ADRA2A
410.8TPH2, SLC6A2, SLC6A3, DBH
5
Hide members
10.8DBH, SLC6A2, ADRA2A, ADRA2C
610.7DRD1, DRD4, DRD5
7
Hide members
10.7SLC6A3, MAOA, DRD1
8
Hide members
10.7TPH2, DBH, MAOA
9
Tyrosine metabolism p.1 (dopamine)
Hide members
10.7COMT, MAOA, DBH
10
Hide members
10.7COMT, MAOA, DBH
11
Hide members
10.6MAOA, SLC6A3
1210.6TPH2, ADRA2C
13
Hide members
10.6ADRA2C, ADRA2A
14
Hide members
10.6MAOA, COMT

Compounds for genes affiliated with Attention Deficit Hyperactivity Disorder

Sources:
45Novoseek, 29IUPHAR, 11DrugBank, 24HMDB, 50PharmGKB, 60Tocris Bioscience, 2BitterDB
See all sources

Compounds related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show top 50)    (show all 210)
idCompoundScoreTop Affiliating Genes
1dopamine45 29 11 2414.7ADRA2C, DBH, DRD1, DRD4, DRD5, MAOA
2norepinephrine45 11 2413.6ADRA2C, ADRA2A, SLC6A2, DRD1, DBH, MAOA
3catecholamine4511.6ADRA2C, ADRA2A, SLC6A2, DBH, MAOA, DRD4
4bromocriptine29 45 1113.5COMT, HTR1B, DRD1, DRD4, DRD5, SLC6A3
5apomorphine45 29 1113.5HTR1B, DRD1, DRD4, DRD5, SLC6A3, ADRA2A
6methamphetamine45 50 1113.5COMT, ADRA2A, ADRA2C, SLC6A2, SLC6A3, MAOA
7maoa4511.5COMT, HTR1B, DRD4, MAOA, DBH, SLC6A3
8pramipexole45 50 29 1114.5SLC6A3, ADRA2A, ADRA2C, DRD5, DRD4, DRD1
9methylphenidate45 50 1113.5COMT, DRD1, DRD5, MAOA, SLC6A3, SLC6A2
10olanzapine50 45 29 11 2415.5DRD5, SLC6A3, ADRA2A, ADRA2C, DRD4, DRD1
11levodopa45 1112.5DRD5, MAOA, DBH, SLC6A3, DRD4, DRD1
12clozapine45 29 50 1114.5DRD1, DRD4, SLC6A3, DRD5, ADRA2C, HTR1B
135-hydroxytryptamine4511.4HTR1B, DRD4, MAOA, DBH, SLC6A3, TPH2
14cabergoline29 45 1113.4ADRA2A, ADRA2C, DRD5, DRD4, DRD1, COMT
15pergolide29 45 1113.4ADRA2C, ADRA2A, COMT, HTR1B, DRD1, DRD4
16ropinirole45 1112.4COMT, HTR1B, DRD1, DRD4, DRD5, ADRA2A
17quetiapine45 50 29 11 2415.4DRD1, DRD4, DRD5, SLC6A3, ADRA2A, ADRA2C
18risperidone29 45 50 60 11 2416.4DRD1, COMT, HTR1B, DRD4, SLC6A3, ADRA2C
196-hydroxydopamine4511.4SLC6A3, DBH, SLC6A2, MAOA, DRD1, DRD4
20cocaine45 1112.3SLC6A3, HTR1B, SLC6A2, COMT, DRD1, DRD4
21nicotine45 50 29 1114.3SLC6A2, SLC6A3, DBH, MAOA, DRD4, DRD1
22lisuride29 45 1113.3DRD1, HTR1B, DRD4, DRD5, ADRA2C, ADRA2A
23tyramine45 29 2413.3SLC6A3, MAOA, ADRA2A, SLC6A2, DBH, COMT
24aripiprazole29 50 45 11 2415.3DRD4, DRD1, ADRA2C, ADRA2A, HTR1B, DRD5
25ziprasidone50 29 45 1114.3ADRA2A, DRD5, DRD4, HTR1B, ADRA2C, DRD1
26paroxetine45 50 29 1114.3COMT, DRD4, SLC6A2, SLC6A3, MAOA, HTR1B
27mptp4511.3COMT, DRD1, MAOA, DBH, SLC6A3, SLC6A2
28Ephedra1111.2MAOA, ADRA2C, ADRA2A, SLC6A2, SLC6A3
29mhpg4511.2DRD4, DBH, SLC6A2, MAOA, COMT
30Methotrimeprazine1111.2ADRA2A, DRD1, DRD4, ADRA2C, DRD5
31asenapine29 1112.2ADRA2C, HTR1B, ADRA2A, DRD4, DRD1
32chlorpromazine45 29 50 1114.1ADRA2A, DRD5, ADRA2C, DRD4, DRD1
33fluoxetine50 45 29 1114.1TPH2, SLC6A2, SLC6A3, HTR1B, MAOA
34amphetamine45 1112.1SLC6A2, SLC6A3, MAOA, DRD4, DRD1
35d amphetamine4511.1SLC6A3, MAOA, DRD1, SLC6A2
36pseudoephedrine45 11 2413.1SLC6A2, ADRA2A, MAOA, SLC6A3
37fenoldopam45 1112.1DRD5, ADRA2A, ADRA2C, DRD1
38imipramine45 50 29 11 2415.1DRD1, MAOA, DBH, SLC6A3, SLC6A2
39terguride29 4512.1ADRA2A, ADRA2C, DRD4, HTR1B
40dopac4511.0DRD1, COMT, MAOA, DBH
41gaba4511.0SLC6A3, MAOA, SLC6A2, DBH, DRD1, DRD4
42paliperidone45 1112.0DRD4, ADRA2A, DRD1, ADRA2C
43amine4511.0COMT, HTR1B, MAOA, DBH, SLC6A2
44homovanillic acid45 2412.0COMT, DBH, SLC6A2, MAOA
45venlafaxine50 45 11 2413.9HTR1B, SLC6A2, SLC6A3, TPH2
46haloperidol45 29 2 50 1114.9SLC6A2, SLC6A3, DRD5, DRD4, DRD1
47nomifensine45 29 1112.7SLC6A2, SLC6A3, MAOA
48phenylpropanolamine45 11 2412.7DRD1, MAOA, ADRA2A
49epinephrine45 11 2412.6COMT, DRD4, MAOA, DBH, SLC6A2, ADRA2A
50p-chloroamphetamine4510.6SLC6A2, SLC6A3, MAOA

GO Terms for genes affiliated with Attention Deficit Hyperactivity Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1integral to plasma membraneGO:00588711.1ADRA2C, ADRA2A, SLC6A2, SLC6A3, DRD5, DRD4

Biological processes related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmissionGO:00726811.4COMT, HTR1B, DRD5, MAOA, DBH, SLC6A3
2response to amphetamineGO:00197511.2DRD1, DRD4, DRD5, DBH
3dopamine catabolic processGO:04242011.2SLC6A3, DBH, MAOA, COMT
4fear responseGO:04259611.1ADRA2A, DBH, DRD4
5regulation of dopamine metabolic processGO:04205311.1DRD1, DRD4, SLC6A3
6negative regulation of cAMP biosynthetic processGO:03081811.1ADRA2A, DRD4, HTR1B
7synaptic transmission, dopaminergicGO:00196311.1DRD1, DRD4, DRD5
8neurotransmitter biosynthetic processGO:04213611.1SLC6A3, MAOA, COMT
9response to cocaineGO:04222011.1SLC6A3, DRD5, HTR1B
10response to painGO:04826511.1COMT, DBH, SLC6A2
11sensitizationGO:04696011.0DRD5, DRD1
12negative regulation of uterine smooth muscle contractionGO:07047311.0ADRA2C, ADRA2A
13activation of MAPK activity by adrenergic receptor signaling pathwayGO:07188311.0ADRA2A, ADRA2C
14epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathwayGO:03562510.9ADRA2C, ADRA2A
15dopamine transportGO:01587210.9SLC6A3, DRD1
16cellular response to catecholamine stimulusGO:07187010.9DRD1, DRD5
17negative regulation of epinephrine secretionGO:03281110.9ADRA2A, ADRA2C
18monoamine transportGO:01584410.9SLC6A3, SLC6A2
19neurotransmitter catabolic processGO:04213510.9COMT, MAOA
20positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathwayGO:01057910.9DRD1, DRD5
21female pregnancyGO:00756510.9COMT, ADRA2A, ADRA2C
22phospholipase C-activating dopamine receptor signaling pathwayGO:06015810.9DRD1, DRD5
23behavioral response to ethanolGO:04814910.9DRD4, DBH
24negative regulation of norepinephrine secretionGO:01070010.8ADRA2A, ADRA2C
25long term synaptic depressionGO:06029210.8DRD1, DRD5
26positive regulation of potassium ion transportGO:04326810.8DRD1, ADRA2A
27dopamine metabolic processGO:04241710.7DRD1, DRD4
28adenylate cyclase-activating dopamine receptor signaling pathwayGO:00719110.7DRD1, DRD5
29behavioral response to cocaineGO:04814810.6DRD4, DRD1
30positive regulation of vasoconstrictionGO:04590710.6ADRA2C, DBH
31prepulse inhibitionGO:06013410.5DRD1, SLC6A3
32activation of protein kinase B activityGO:03214810.3ADRA2C, ADRA2A

Molecular functions related to Attention Deficit Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1dopamine bindingGO:03524010.9SLC6A3, DRD5, DRD4, DRD1
2dopamine neurotransmitter receptor activityGO:00495210.8DRD1, DRD4, DRD5
3drug bindingGO:00814410.7SLC6A3, DRD4, HTR1B
4dopamine neurotransmitter receptor activity, coupled via GsGO:00158810.7DRD5, DRD1
5alpha2-adrenergic receptor activityGO:00493810.6ADRA2A, ADRA2C
6monoamine transmembrane transporter activityGO:00850410.5SLC6A2, SLC6A3
7epinephrine bindingGO:05137910.3ADRA2C, ADRA2A

Products for genes affiliated with Attention Deficit Hyperactivity Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Attention Deficit Hyperactivity Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet