MCID: ATT013
MIFTS: 63

Attention Deficit-Hyperactivity Disorder malady

Genetic diseases (common), Mental diseases categories

Summaries for Attention Deficit-Hyperactivity Disorder

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NINDS:42 Attention deficit-hyperactivity disorder (ADHD) is a neurobehavioral disorder that affects 3-5 percent of all American children. It interferes with a person's ability to stay on a task and to exercise age-appropriate inhibition (cognitive alone or both cognitive and behavioral). Some of the warning signs of ADHD include failure to listen to instructions, inability to organize oneself and school work, fidgeting with hands and feet, talking too much, leaving projects, chores and homework unfinished, and having trouble paying attention to and responding to details. There are several types of ADHD: a predominantly inattentive subtype, a predominantly hyperactive-impulsive subtype, and a combined subtype. ADHD is usually diagnosed in childhood, although the condition can continue into the adult years.

MalaCards based summary: Attention Deficit-Hyperactivity Disorder, also known as attention deficit hyperactivity disorder, is related to oppositional defiant disorder and conduct disorder, and has symptoms including autosomal dominant inheritance, hyperactivity and attention deficit hyperactivity disorder. An important gene associated with Attention Deficit-Hyperactivity Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Monoamine GPCRs and Monoamine Transport. The drugs selegiline and selegiline hydrochloride and the compounds (+)-butaclamol and rotigotine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotype behavior/neurological.

Disease Ontology:9 A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age.

MedlinePlus:32 Is it hard for your child to sit still? does your child act without thinking first? does your child start but not finish things? if so, your child may have attention deficit hyperactivity disorder (adhd). nearly everyone shows some of these behaviors at times, but adhd lasts more than 6 months and causes problems in school, at home and in social situations. adhd is more common in boys than girls. it affects 3-5 percent of all american children. the main features of adhd are inattention hyperactivity impulsivity no one knows exactly what causes adhd. it sometimes runs in families, so genetics may be a factor. there may also be environmental factors. a complete evaluation by a trained professional is the only way to know for sure if your child has adhd. treatment may include medicine to control symptoms, therapy, or both. structure at home and at school is important. parent training may also help. nih: national institute of mental health

CDC:3 Did you know that experts recommend behavior intervention as the first and best treatment option for preschool children with ADHD?

Wikipedia:63 Attention deficit hyperactivity disorder (ADHD, similar to hyperkinetic disorder in the ICD-10) is a... more...

Description from OMIM:45 143465

Aliases & Classifications for Attention Deficit-Hyperactivity Disorder

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Sources:
45OMIM, 31MalaCards, 9Disease Ontology, 10diseasecard, 42NINDS, 11DISEASES, 43Novoseek, 22GTR, 32MedlinePlus, 3CDC, 60UMLS, 55SNOMED-CT, 27ICD9CM, 33MeSH, 38NCIt, 25ICD10
See all sources

Attention Deficit-Hyperactivity Disorder, Aliases & Descriptions:

Name: Attention Deficit-Hyperactivity Disorder 45 42
Attention Deficit Hyperactivity Disorder 31 9 11 32 60
Adhd 31 9 42 3
Attention Deficit Disorder 9 43 60
 
Attention-Deficit Hyperactivity Disorder 43 22
Attention-Deficit/hyperactivity Disorder, Predominantly Inattentive Type 60
Attention Deficit-Hyperactivity Disorder, Susceptibility to 10
Hyperkinetic Disorder 9


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Mental diseases


External Ids:

OMIM45 143465
Disease Ontology9 DOID:1094
ICD9CM27 314.00
SNOMED-CT55 23148009
MeSH33 D001289
NCIt38 C35092
ICD1025 F90, F90.0, F90.9

Related Diseases for Attention Deficit-Hyperactivity Disorder

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Diseases related to Attention Deficit-Hyperactivity Disorder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1oppositional defiant disorder32.1SLC6A3, DRD4
2conduct disorder31.6SLC6A3, DRD5, DRD4, COMT
3schizophrenia31.5DRD4, COMT
4personality disorder31.5TPH2, DRD4, SLC6A3
5alcohol dependence31.4DRD4
6antisocial personality disorder31.3SLC6A3
7substance abuse31.2DRD4, SLC6A3
8eating disorder31.0SLC6A3, COMT
9anxiety disorder31.0TPH2, COMT, SLC6A3
10gilles de la tourette syndrome30.9SLC6A3, DRD5, DRD4
11obsessive-compulsive disorder30.8TPH2, COMT, DRD4, SLC6A3
12bipolar disorder30.8TPH2, COMT, DRD4, DRD5, SLC6A3
13substance dependence30.8COMT, DRD4, DRD5, SLC6A3
14mood disorder30.6TPH2, COMT, DRD4, SLC6A3
15pathological gambling30.4SLC6A3, DRD4
16alcohol abuse30.4SLC6A3, COMT
17panic disorder30.4TPH2, COMT, DRD4
18psychotic disorder30.3TPH2, COMT, DRD4, SLC6A3
19autism spectrum disorder11.0
20tic disorder11.0
21developmental coordination disorder10.9
22pervasive developmental disorder10.9
23blindness10.9
24learning disability10.8
25obesity10.8
26autistic disorder10.7
27dyslexia10.7
28cerebritis10.7
29restless legs syndrome10.7
30dysthymic disorder10.7
31fetal alcohol spectrum disorder10.7
32reading disorder10.7
33borderline personality disorder10.6
34childhood-onset schizophrenia10.6
35mental retardation10.6
36velocardiofacial syndrome10.6
37cocaine dependence10.6
38bipolar i disorder10.6
39phenylketonuria10.5
40aarskog-scott syndrome10.5
41opioid dependence10.5
42neurofibromatosis, type 110.5
43fragile x syndrome10.5
44neurofibromatosis10.5
45chronic tic disorder10.5
46cocaine abuse10.5
47pervasive developmental disorder not otherwise specified10.5
48febrile seizures10.5
49asthma10.4
50williams-beuren syndrome10.4

Graphical network of the top 20 diseases related to Attention Deficit-Hyperactivity Disorder:



Diseases related to attention deficit-hyperactivity disorder

Symptoms for Attention Deficit-Hyperactivity Disorder

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Symptoms by clinical synopsis from OMIM:

143465

Clinical features from OMIM:

143465

HPO human phenotypes related to Attention Deficit-Hyperactivity Disorder:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hyperactivity HP:0000752
3 attention deficit hyperactivity disorder HP:0007018

Drugs & Therapeutics for Attention Deficit-Hyperactivity Disorder

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Genetic Tests for Attention Deficit-Hyperactivity Disorder

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Genetic tests related to Attention Deficit-Hyperactivity Disorder:

id Genetic test Affiliating Genes
1 Attention Deficit-Hyperactivity Disorder22

Anatomical Context for Attention Deficit-Hyperactivity Disorder

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MalaCards organs/tissues related to Attention Deficit-Hyperactivity Disorder:

31
Brain, Testes, Eye, Heart, Thyroid, Cortex, Skin, Prefrontal cortex, Cingulate cortex, Amygdala

Animal Models for Attention Deficit-Hyperactivity Disorder or affiliated genes

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MGI Mouse Phenotypes related to Attention Deficit-Hyperactivity Disorder:

35
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9SLC6A3, DRD4, COMT, DOCK3, TPH2, PTGDS

Publications for Attention Deficit-Hyperactivity Disorder

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Articles related to Attention Deficit-Hyperactivity Disorder:

(show top 50)    (show all 1188)
idTitleAuthorsYear
1
Effect of atomoxetine on the cognitive functions in treatment of attention deficit hyperactivity disorder in children with congenital hypothyroidism: a pilot study. (25896257)
2015
2
Cerebellar morphology and the effects of stimulant medications in youths with attention deficit-hyperactivity disorder. (24077064)
2014
3
Reading outcomes of children and adolescents with attention-deficit/hyperactivity disorder and dyslexia following atomoxetine treatment. (25299355)
2014
4
Neurofeedback in attention-deficit/hyperactivity disorder - different models, different ways of application. (25374528)
2014
5
Does diagnosis affect the predictive accuracy of risk assessment tools for juvenile offenders: Conduct Disorder and Attention Deficit Hyperactivity Disorder. (25173178)
2014
6
Diminished testing benefits in young adults with attention-deficit hyperactivity disorder. (25385006)
2014
7
Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. (25056274)
2014
8
Nicotinic attention-deficit/hyperactivity disorder treatment. (24370349)
2014
9
Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. (23461725)
2013
10
Objective measurement of weekly physical activity and sensory modulation problems in children with attention deficit hyperactivity disorder. (23927990)
2013
11
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
12
Attention deficit hyperactivity disorder in cocaine-dependent adults: a psychiatric comorbidity analysis. (23952892)
2013
13
Adult attention deficit hyperactivity disorder symptoms and five-factor model traits in a clinical sample: a structural equation modeling approach. (24080671)
2013
14
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
15
Subthreshold attention-deficit/hyperactivity disorder is associated with functional impairments across domains: a comprehensive analysis in a large-scale community study. (24318039)
2013
16
EEG brain mapping and brain connectivity index for subtypes classification of attention deficit hyperactivity disorder children during the eye-opened period. (24111455)
2013
17
Attention-deficit/hyperactivity disorder, physical health, and lifestyle in older adults. (23711084)
2013
18
Early-age clinical and developmental features associated to Substance Use Disorders in Attention-Deficit/Hyperactivity Disorder in Adults. (24411652)
2013
19
The merit of sociological accounts of disorder: The Attention-Deficit Hyperactivity Disorder case. (24287297)
2013
20
Reply to: Attention-Deficit/Hyperactivity Disorder and Solar Irradiance: A Cloudy Perspective. (24252358)
2013
21
Fatty acid correlates of temperament in adolescent boys with attention deficit hyperactivity disorder. (23566869)
2013
22
Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder. (23734235)
2013
23
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis. (23735885)
2013
24
Drugs for attention deficit-hyperactivity disorder do not increase the mid-term risk of sudden death in children: a meta-analysis of observational studies. (23669111)
2013
25
Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. (21824190)
2012
26
Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items. (23267399)
2012
27
Parent-reported attention-deficit hyperactivity disorder and subtypes of conduct disorder as risk factor of recidivism in detained male adolescents. (21420836)
2012
28
Identification of attention-deficit-hyperactivity disorder and conduct disorder in Mexican children by the scale for evaluation of deficit of attention and hyperactivity. (20934222)
2011
29
Genome-wide association study in German patients with attention deficit/hyperactivity disorder. (22012869)
2011
30
DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. (20736997)
2010
31
Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression. (20862695)
2010
32
Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms. (20943059)
2010
33
Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. (19150055)
2009
34
Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (18428117)
2008
35
A case-control association study of the polymorphism at the promoter region of the DRD4 gene in Korean boys with attention deficit-hyperactivity disorder: evidence of association with the -521 C/T SNP. (17850946)
2008
36
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. (18413706)
2008
37
Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder. (17466583)
2007
38
Analysis of the dopamine D4 receptor gene variants in attention deficit hyperactivity disorder]. (17879560)
2007
39
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. (16854470)
2006
40
The dopamine transporter gene and the impulsivity phenotype in attention deficit hyperactivity disorder: a case-control association study in a Korean sample. (16368111)
2006
41
Candidate gene studies of attention-deficit/hyperactivity disorder. (16961425)
2006
42
A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms. (16616730)
2006
43
Attention-deficit/hyperactivity disorder (ADHD) and variable clinical expression of Aarskog-Scott syndrome due to a novel FGD1 gene mutation (R408Q). (15809997)
2005
44
Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. (16380908)
2005
45
Meta-analysis of candidate genes in attention-deficit hyperactivity disorder]. (16389711)
2005
46
Association between dopamine beta hydroxylase gene and attention deficit hyperactivity disorder complicated with disruptive behavior disorder]. (15796803)
2005
47
Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (16178932)
2005
48
Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children]. (15205702)
2004
49
Dopamine genes and attention-deficit hyperactivity disorder: a review. (12587848)
2003
50
Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder. (10654661)
2000

Variations for Attention Deficit-Hyperactivity Disorder

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Expression for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Search GEO for disease gene expression data for Attention Deficit-Hyperactivity Disorder.

Pathways for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Pathways related to Attention Deficit-Hyperactivity Disorder according to GeneCards Suite gene sharing:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0DRD5, DRD4
2
Show member pathways
Serotonin Transporter Activity36
9.7SLC6A3, TPH2
3
Show member pathways
8.7SLC6A3, DRD5, DRD4, COMT, TPH2

Compounds for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Compounds related to Attention Deficit-Hyperactivity Disorder according to GeneCards Suite gene sharing:

(show all 49)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol43 2811.4DRD4, DRD5
2rotigotine28 43 1212.3DRD5, DRD4
3fluphenazine28 43 49 1213.3DRD4, DRD5
4spiperone43 2811.3DRD4, DRD5
5lisuride43 28 1212.3DRD5, DRD4
6raclopride43 2811.3SLC6A3, DRD4
7piperazine43 1211.2DRD4, SLC6A3
8sulpiride43 28 1212.2SLC6A3, DRD4
9piperidine4310.2DRD4, SLC6A3
10quinpirole43 2811.1SLC6A3, DRD4
11aripiprazole28 43 49 24 1214.1DRD5, DRD4
12phencyclidine43 28 1212.1SLC6A3, DRD4
13ziprasidone28 49 43 1213.1DRD4, DRD5
14quetiapine43 49 28 24 1214.0SLC6A3, DRD5, DRD4
15mhpg4310.0COMT, DRD4
16haloperidol43 49 28 2 1214.0SLC6A3, DRD5, DRD4
17chlorpromazine28 43 49 1213.0DRD5, DRD4
18carbidopa43 2811.0SLC6A3, COMT
19ropinirole43 1210.9COMT, DRD4, DRD5
20pergolide43 28 1211.9DRD5, DRD4, COMT
21cabergoline43 28 1211.9COMT, DRD4, DRD5
22catecholamine439.8COMT, DRD4, DRD5
23fluvoxamine43 49 1211.8COMT, SLC6A3
24tyramine43 28 2411.8COMT, SLC6A3
25selegiline43 1210.8SLC6A3, COMT
26heroin43 49 1211.8SLC6A3, DRD4, COMT
27paroxetine43 49 28 1212.8COMT, DRD4, SLC6A3
28methamphetamine43 49 1211.8SLC6A3, DRD4, COMT
29risperidone43 49 28 59 24 1214.8COMT, DRD4, SLC6A3
306-hydroxydopamine439.8SLC6A3, DRD4, COMT
31cocaine43 1210.7SLC6A3, DRD4, COMT
32bupropion49 43 24 1212.7COMT, SLC6A3
33nicotine43 28 49 1212.6SLC6A3, DRD4, COMT
34valine439.6COMT, DRD4, SLC6A3
35mptp439.6SLC6A3, COMT
36amphetamine43 49 1211.6DRD4, SLC6A3
37venlafaxine43 49 24 1212.6SLC6A3, COMT, TPH2
38fluoxetine43 49 28 1212.6TPH2, SLC6A3
39methylphenidate43 49 1211.6SLC6A3, DRD5, DRD4, COMT
40pramipexole43 28 49 1212.6COMT, DRD4, DRD5, SLC6A3
41apomorphine28 43 1211.6SLC6A3, DRD5, DRD4, COMT
42bromocriptine43 28 1211.6COMT, DRD4, DRD5, SLC6A3
43olanzapine43 49 28 24 1213.6SLC6A3, DRD5, DRD4, COMT
44levodopa43 1210.5COMT, DRD4, DRD5, SLC6A3
45clozapine43 28 49 1212.5SLC6A3, DRD5, DRD4, COMT
46norepinephrine43 24 1211.5COMT, DRD4, DRD5, SLC6A3
47dopamine43 28 24 1212.5SLC6A3, DRD5, DRD4, COMT
48maoa439.4TPH2, COMT, DRD4, SLC6A3
495-hydroxytryptamine439.3SLC6A3, DRD4, COMT, TPH2

GO Terms for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Biological processes related to Attention Deficit-Hyperactivity Disorder according to GeneCards Suite gene sharing:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, dopaminergicGO:000196310.0DRD5, DRD4
2regulation of dopamine metabolic processGO:004205310.0SLC6A3, DRD4
3circadian rhythmGO:00076239.8DRD4, TPH2
4response to cocaineGO:00422209.8SLC6A3, DRD5
5dopamine catabolic processGO:00424209.8SLC6A3, COMT
6response to amphetamineGO:00019759.7DRD5, DRD4
7neurotransmitter biosynthetic processGO:00421369.6COMT, SLC6A3

Molecular functions related to Attention Deficit-Hyperactivity Disorder according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:000495210.0DRD5, DRD4
2dopamine bindingGO:00352409.3SLC6A3, DRD5, DRD4

Products for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Sources for Attention Deficit-Hyperactivity Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCIt
39NDF-RT
42NINDS
43Novoseek
45OMIM
46OMIM via Orphanet
50PubMed
51QIAGEN
56SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet