MCID: ATT013
MIFTS: 62

Attention Deficit-Hyperactivity Disorder malady

Genetic diseases (common), Mental diseases categories

Summaries for Attention Deficit-Hyperactivity Disorder

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NINDS:44 Attention deficit-hyperactivity disorder (ADHD) is a neurobehavioral disorder that affects 3-5 percent of all American children. It interferes with a person's ability to stay on a task and to exercise age-appropriate inhibition (cognitive alone or both cognitive and behavioral). Some of the warning signs of ADHD include failure to listen to instructions, inability to organize oneself and school work, fidgeting with hands and feet, talking too much, leaving projects, chores and homework unfinished, and having trouble paying attention to and responding to details. There are several types of ADHD: a predominantly inattentive subtype, a predominantly hyperactive-impulsive subtype, and a combined subtype. ADHD is usually diagnosed in childhood, although the condition can continue into the adult years.

MalaCards based summary: Attention Deficit-Hyperactivity Disorder, also known as attention deficit hyperactivity disorder, is related to conduct disorder and oppositional defiant disorder, and has symptoms including autosomal dominant inheritance, hyperactivity and attention deficit hyperactivity disorder. An important gene associated with Attention Deficit-Hyperactivity Disorder is DRD4 (dopamine receptor D4), and among its related pathways are Monoamine GPCRs and Monoamine Transport. The compounds (+)-butaclamol and rotigotine have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and eye, and related mouse phenotype behavior/neurological.

Disease Ontology:10 A specific developmental disorder that is characterized by co-existence of attentional problems and hyperactivity, with each behavior occurring infrequently alone" and symptoms starting before seven years of age.

MedlinePlus:34 Is it hard for your child to sit still? does your child act without thinking first? does your child start but not finish things? if so, your child may have attention deficit hyperactivity disorder (adhd). nearly everyone shows some of these behaviors at times, but adhd lasts more than 6 months and causes problems in school, at home and in social situations. adhd is more common in boys than girls. it affects 3-5 percent of all american children. the main features of adhd are inattention hyperactivity impulsivity no one knows exactly what causes adhd. it sometimes runs in families, so genetics may be a factor. there may also be environmental factors. a complete evaluation by a trained professional is the only way to know for sure if your child has adhd. treatment may include medicine to control symptoms, therapy, or both. structure at home and at school is important. parent training may also help. nih: national institute of mental health

CDC:4 Did you know that experts recommend behavior intervention as the first and best treatment option for preschool children with ADHD?

Wikipedia:65 Attention deficit hyperactivity disorder (ADHD, similar to hyperkinetic disorder in the ICD-10) is a... more...

Description from OMIM:47 143465

Aliases & Classifications for Attention Deficit-Hyperactivity Disorder

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Sources:
47OMIM, 33MalaCards, 10Disease Ontology, 11diseasecard, 44NINDS, 12DISEASES, 45Novoseek, 24GTR, 34MedlinePlus, 4CDC, 57SNOMED-CT, 29ICD9CM, 35MeSH, 62UMLS, 40NCIt, 27ICD10
See all sources

Attention Deficit-Hyperactivity Disorder, Aliases & Descriptions:

Name: Attention Deficit-Hyperactivity Disorder 47 44
Attention Deficit Hyperactivity Disorder 33 10 12 34
Adhd 33 10 44 4
Attention-Deficit Hyperactivity Disorder 45 24
 
Attention Deficit Disorder 10 45
Attention Deficit-Hyperactivity Disorder, Susceptibility to 11
Hyperkinetic Disorder 10


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common)
Anatomical: Mental diseases


External Ids:

OMIM47 143465
Disease Ontology10 DOID:1094
ICD9CM29 314.00
SNOMED-CT57 23148009
MeSH35 D001289
NCIt40 C35092
ICD1027 F90, F90.0, F90.9

Related Diseases for Attention Deficit-Hyperactivity Disorder

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Diseases related to Attention Deficit-Hyperactivity Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 217)
idRelated DiseaseScoreTop Affiliating Genes
1conduct disorder31.7COMT, DRD4, DRD5, SLC6A3
2oppositional defiant disorder31.6DRD4, SLC6A3
3schizophrenia31.3COMT, DRD4
4personality disorder31.2SLC6A3, DRD4, TPH2
5bipolar disorder31.2DRD5, DRD4, COMT, TPH2, SLC6A3
6anxiety disorder31.0COMT, SLC6A3, TPH2
7alcohol dependence30.9DRD4
8obsessive-compulsive disorder30.9SLC6A3, DRD4, COMT, TPH2
9eating disorder30.9SLC6A3, COMT
10substance dependence30.9SLC6A3, DRD5, DRD4, COMT
11mood disorder30.8TPH2, DRD4, SLC6A3, COMT
12antisocial personality disorder30.7SLC6A3
13substance abuse30.7DRD4, SLC6A3
14gilles de la tourette syndrome30.7SLC6A3, DRD5, DRD4
15panic disorder30.4COMT, TPH2, DRD4
16psychotic disorder30.4SLC6A3, COMT, DRD4, TPH2
17alcohol abuse30.2COMT, SLC6A3
18pathological gambling29.9SLC6A3, DRD4
19autism spectrum disorder11.0
20tic disorder11.0
21developmental coordination disorder10.9
22pervasive developmental disorder10.9
23blindness10.9
24learning disability10.8
25obesity10.8
26autistic disorder10.7
27dyslexia10.7
28cerebritis10.7
29restless legs syndrome10.7
30dysthymic disorder10.7
31fetal alcohol spectrum disorder10.7
32reading disorder10.7
33borderline personality disorder10.6
34childhood-onset schizophrenia10.6
35mental retardation10.6
36velocardiofacial syndrome10.6
37cocaine dependence10.6
38bipolar i disorder10.6
39phenylketonuria10.5
40aarskog-scott syndrome10.5
41opioid dependence10.5
42neurofibromatosis, type 110.5
43fragile x syndrome10.5
44neurofibromatosis10.5
45chronic tic disorder10.5
46cocaine abuse10.5
47pervasive developmental disorder not otherwise specified10.5
48febrile seizures10.5
49asthma10.4
50williams-beuren syndrome10.4

Graphical network of the top 20 diseases related to Attention Deficit-Hyperactivity Disorder:



Diseases related to attention deficit-hyperactivity disorder

Symptoms for Attention Deficit-Hyperactivity Disorder

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Symptoms by clinical synopsis from OMIM:

143465

Clinical features from OMIM:

143465

HPO human phenotypes related to Attention Deficit-Hyperactivity Disorder:

id Description Frequency HPO Source Accession
1 autosomal dominant inheritance HP:0000006
2 hyperactivity HP:0000752
3 attention deficit hyperactivity disorder HP:0007018

Drugs & Therapeutics for Attention Deficit-Hyperactivity Disorder

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Drug clinical trials:

Search ClinicalTrials for Attention Deficit-Hyperactivity Disorder

Search NIH Clinical Center for Attention Deficit-Hyperactivity Disorder

Genetic Tests for Attention Deficit-Hyperactivity Disorder

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Genetic tests related to Attention Deficit-Hyperactivity Disorder:

id Genetic test Affiliating Genes
1 Attention Deficit-Hyperactivity Disorder24

Anatomical Context for Attention Deficit-Hyperactivity Disorder

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MalaCards organs/tissues related to Attention Deficit-Hyperactivity Disorder:

33
Brain, Testes, Eye, Heart, Thyroid, Cortex, Skin, Prefrontal cortex, Cingulate cortex, Amygdala

Animal Models for Attention Deficit-Hyperactivity Disorder or affiliated genes

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MGI Mouse Phenotypes related to Attention Deficit-Hyperactivity Disorder:

37
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053867.9SLC6A3, DRD4, COMT, DOCK3, TPH2, PTGDS

Publications for Attention Deficit-Hyperactivity Disorder

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Articles related to Attention Deficit-Hyperactivity Disorder:

(show top 50)    (show all 1188)
idTitleAuthorsYear
1
Effect of atomoxetine on the cognitive functions in treatment of attention deficit hyperactivity disorder in children with congenital hypothyroidism: a pilot study. (25896257)
2015
2
Cerebellar morphology and the effects of stimulant medications in youths with attention deficit-hyperactivity disorder. (24077064)
2014
3
Reading outcomes of children and adolescents with attention-deficit/hyperactivity disorder and dyslexia following atomoxetine treatment. (25299355)
2014
4
Neurofeedback in attention-deficit/hyperactivity disorder - different models, different ways of application. (25374528)
2014
5
Does diagnosis affect the predictive accuracy of risk assessment tools for juvenile offenders: Conduct Disorder and Attention Deficit Hyperactivity Disorder. (25173178)
2014
6
Diminished testing benefits in young adults with attention-deficit hyperactivity disorder. (25385006)
2014
7
Neonatal jaundice and increased risk of attention-deficit hyperactivity disorder: a population-based cohort study. (25056274)
2014
8
Nicotinic attention-deficit/hyperactivity disorder treatment. (24370349)
2014
9
Association between TPH2 gene polymorphisms and attention deficit hyperactivity disorder in Korean children. (23461725)
2013
10
Objective measurement of weekly physical activity and sensory modulation problems in children with attention deficit hyperactivity disorder. (23927990)
2013
11
Influence of attention-deficit/hyperactivity disorder on binge eating behaviors and psychiatric comorbidity profile of obese women. (24246603)
2013
12
Attention deficit hyperactivity disorder in cocaine-dependent adults: a psychiatric comorbidity analysis. (23952892)
2013
13
Adult attention deficit hyperactivity disorder symptoms and five-factor model traits in a clinical sample: a structural equation modeling approach. (24080671)
2013
14
The role of obsessive-compulsive symptoms in the psychopathological profile of children with chronic tic disorder and attention-deficit hyperactivity disorder. (23639924)
2013
15
Subthreshold attention-deficit/hyperactivity disorder is associated with functional impairments across domains: a comprehensive analysis in a large-scale community study. (24318039)
2013
16
EEG brain mapping and brain connectivity index for subtypes classification of attention deficit hyperactivity disorder children during the eye-opened period. (24111455)
2013
17
Attention-deficit/hyperactivity disorder, physical health, and lifestyle in older adults. (23711084)
2013
18
Early-age clinical and developmental features associated to Substance Use Disorders in Attention-Deficit/Hyperactivity Disorder in Adults. (24411652)
2013
19
The merit of sociological accounts of disorder: The Attention-Deficit Hyperactivity Disorder case. (24287297)
2013
20
Reply to: Attention-Deficit/Hyperactivity Disorder and Solar Irradiance: A Cloudy Perspective. (24252358)
2013
21
Fatty acid correlates of temperament in adolescent boys with attention deficit hyperactivity disorder. (23566869)
2013
22
Sleep promotes consolidation of emotional memory in healthy children but not in children with attention-deficit hyperactivity disorder. (23734235)
2013
23
Age-related change of neurochemical abnormality in attention-deficit hyperactivity disorder: a meta-analysis. (23735885)
2013
24
Drugs for attention deficit-hyperactivity disorder do not increase the mid-term risk of sudden death in children: a meta-analysis of observational studies. (23669111)
2013
25
Motor examination in children with Attention-deficit/hyperactivity Disorder and Asperger Syndrome. (21824190)
2012
26
Co-morbidity and factor analysis on attention deficit hyperactivity disorder and autism spectrum disorder DSM-IV-derived items. (23267399)
2012
27
Parent-reported attention-deficit hyperactivity disorder and subtypes of conduct disorder as risk factor of recidivism in detained male adolescents. (21420836)
2012
28
Identification of attention-deficit-hyperactivity disorder and conduct disorder in Mexican children by the scale for evaluation of deficit of attention and hyperactivity. (20934222)
2011
29
Genome-wide association study in German patients with attention deficit/hyperactivity disorder. (22012869)
2011
30
DAT1 and COMT effects on delay discounting and trait impulsivity in male adolescents with attention deficit/hyperactivity disorder and healthy controls. (20736997)
2010
31
Polymorphisms of the steroid sulfatase (STS) gene are associated with attention deficit hyperactivity disorder and influence brain tissue mRNA expression. (20862695)
2010
32
Attention-deficit hyperactivity disorder and intellectual disability: a study of association with brain-derived neurotrophic factor gene polymorphisms. (20943059)
2010
33
Association between homozygosity of a G allele of the alpha-2a-adrenergic receptor gene and methylphenidate response in Korean children and adolescents with attention-deficit/hyperactivity disorder. (19150055)
2009
34
Neurotrophic factor-related gene polymorphisms and adult attention deficit hyperactivity disorder (ADHD) score in a high-risk male population. (18428117)
2008
35
A case-control association study of the polymorphism at the promoter region of the DRD4 gene in Korean boys with attention deficit-hyperactivity disorder: evidence of association with the -521 C/T SNP. (17850946)
2008
36
Dissociated functional brain abnormalities of inhibition in boys with pure conduct disorder and in boys with pure attention deficit hyperactivity disorder. (18413706)
2008
37
Somatosensory evoked potentials in attention deficit/hyperactivity disorder and tic disorder. (17466583)
2007
38
Analysis of the dopamine D4 receptor gene variants in attention deficit hyperactivity disorder]. (17879560)
2007
39
Possible confusion between primary hypersomnia and adult attention-deficit/hyperactivity disorder. (16854470)
2006
40
The dopamine transporter gene and the impulsivity phenotype in attention deficit hyperactivity disorder: a case-control association study in a Korean sample. (16368111)
2006
41
Candidate gene studies of attention-deficit/hyperactivity disorder. (16961425)
2006
42
A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms. (16616730)
2006
43
Attention-deficit/hyperactivity disorder (ADHD) and variable clinical expression of Aarskog-Scott syndrome due to a novel FGD1 gene mutation (R408Q). (15809997)
2005
44
Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. (16380908)
2005
45
Meta-analysis of candidate genes in attention-deficit hyperactivity disorder]. (16389711)
2005
46
Association between dopamine beta hydroxylase gene and attention deficit hyperactivity disorder complicated with disruptive behavior disorder]. (15796803)
2005
47
Attention deficit hyperactivity disorder with reading disabilities: preliminary genetic findings on the involvement of the ADRA2A gene. (16178932)
2005
48
Association of dopamine beta-hydroxylase polymorphism with attention deficit hyperactivity disorder in children]. (15205702)
2004
49
Dopamine genes and attention-deficit hyperactivity disorder: a review. (12587848)
2003
50
Coloboma mouse mutant as an animal model of hyperkinesis and attention deficit hyperactivity disorder. (10654661)
2000

Variations for Attention Deficit-Hyperactivity Disorder

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Expression for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Search GEO for disease gene expression data for Attention Deficit-Hyperactivity Disorder.

Pathways for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Pathways related to Attention Deficit-Hyperactivity Disorder according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
10.0DRD5, DRD4
2
Show member pathways
Serotonin Transporter Activity38
9.7SLC6A3, TPH2
3
Show member pathways
8.7SLC6A3, DRD5, DRD4, COMT, TPH2

Compounds for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Compounds related to Attention Deficit-Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1(+)-butaclamol45 3011.4DRD4, DRD5
2rotigotine30 45 1312.3DRD5, DRD4
3fluphenazine30 45 51 1313.3DRD5, DRD4
4spiperone45 3011.3DRD4, DRD5
5lisuride45 30 1312.3DRD4, DRD5
6raclopride45 3011.3DRD4, SLC6A3
7piperazine45 1311.2DRD4, SLC6A3
8sulpiride45 30 1312.2DRD4, SLC6A3
9piperidine4510.2DRD4, SLC6A3
10phencyclidine45 30 1312.1SLC6A3, DRD4
11aripiprazole30 45 51 26 1314.1DRD4, DRD5
12quinpirole45 3011.1DRD4, SLC6A3
13ziprasidone30 51 45 1313.0DRD4, DRD5
14quetiapine45 51 30 26 1314.0DRD5, SLC6A3, DRD4
15mhpg4510.0COMT, DRD4
16haloperidol45 51 30 3 1314.0DRD4, DRD5, SLC6A3
17carbidopa45 3011.0COMT, SLC6A3
18chlorpromazine30 45 51 1313.0DRD4, DRD5
19ropinirole45 1310.9DRD5, DRD4, COMT
20pergolide45 30 1311.9DRD5, COMT, DRD4
21cabergoline45 30 1311.9COMT, DRD4, DRD5
22catecholamine459.8COMT, DRD4, DRD5
23fluvoxamine45 51 1311.8SLC6A3, COMT
24tyramine45 30 2611.8COMT, SLC6A3
25amphetamine45 51 1311.8DRD4, SLC6A3
26selegiline45 1310.8COMT, SLC6A3
27heroin45 51 1311.8COMT, SLC6A3, DRD4
28paroxetine45 51 30 1312.8DRD4, COMT, SLC6A3
29methamphetamine45 51 1311.8SLC6A3, DRD4, COMT
30risperidone45 51 30 61 26 1314.8DRD4, COMT, SLC6A3
316-hydroxydopamine459.8SLC6A3, DRD4, COMT
32bupropion51 45 26 1312.7SLC6A3, COMT
33cocaine45 1310.7DRD4, SLC6A3, COMT
34nicotine45 30 51 1312.6COMT, DRD4, SLC6A3
35valine459.6COMT, SLC6A3, DRD4
36mptp459.6COMT, SLC6A3
37venlafaxine45 51 26 1312.6COMT, TPH2, SLC6A3
38methylphenidate45 51 1311.6DRD4, SLC6A3, COMT, DRD5
39pramipexole45 30 51 1312.6COMT, SLC6A3, DRD4, DRD5
40apomorphine30 45 1311.6DRD5, SLC6A3, DRD4, COMT
41bromocriptine45 30 1311.6COMT, DRD4, DRD5, SLC6A3
42olanzapine45 51 30 26 1313.6DRD4, SLC6A3, COMT, DRD5
43levodopa45 1310.5SLC6A3, DRD5, COMT, DRD4
44clozapine45 30 51 1312.5SLC6A3, DRD5, DRD4, COMT
45norepinephrine45 26 1311.5SLC6A3, COMT, DRD5, DRD4
46dopamine45 30 26 1312.5DRD4, DRD5, SLC6A3, COMT
47fluoxetine45 51 30 1312.4TPH2, SLC6A3
48maoa459.4DRD4, SLC6A3, COMT, TPH2
495-hydroxytryptamine459.3TPH2, COMT, DRD4, SLC6A3

GO Terms for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Biological processes related to Attention Deficit-Hyperactivity Disorder according to GeneCards/GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1synaptic transmission, dopaminergicGO:000196310.0DRD5, DRD4
2regulation of dopamine metabolic processGO:004205310.0DRD4, SLC6A3
3circadian rhythmGO:00076239.8TPH2, DRD4
4response to cocaineGO:00422209.8SLC6A3, DRD5
5dopamine catabolic processGO:00424209.8COMT, SLC6A3
6response to amphetamineGO:00019759.7DRD5, DRD4
7neurotransmitter biosynthetic processGO:00421369.6COMT, SLC6A3

Molecular functions related to Attention Deficit-Hyperactivity Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1dopamine neurotransmitter receptor activityGO:000495210.0DRD5, DRD4
2dopamine bindingGO:00352409.3SLC6A3, DRD5, DRD4

Products for genes affiliated with Attention Deficit-Hyperactivity Disorder

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Sources for Attention Deficit-Hyperactivity Disorder

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4CDC
15ExPASy
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
52PubMed
53QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet