MCID: ATT003
MIFTS: 44

Attenuated Familial Adenomatous Polyposis malady

Categories: Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases

Aliases & Classifications for Attenuated Familial Adenomatous Polyposis

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Sources:
45NIH Rare Diseases, 51Orphanet, 22GeneTests, 24GTR, 65UMLS, 28ICD10 via Orphanet, 37MESH via Orphanet, 66UMLS via Orphanet
See all MalaCards sources

Aliases & Descriptions for Attenuated Familial Adenomatous Polyposis:

Name: Attenuated Familial Adenomatous Polyposis 45 51
Attenuated Fap 45 22 51 24
Attenuated Adenomatous Polyposis Coli 45 22 24
Attenuated Familial Polyposis Coli 45 51
Aapc 45 22
 
Afap 45 51
Familial Adenomatous Polyposis, Attenuated 65
Adenomatous Polyposis Coli, Attenuated 65
Hereditary Flat Adenoma Syndrome 22
Mild Form of Fap 45

Characteristics:

Orphanet epidemiological data:

51
attenuated fap:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Adult

Classifications:



External Ids:

Orphanet51 220460
ICD10 via Orphanet28 D12.6
MESH via Orphanet37 C538265
UMLS via Orphanet66 C2674616
UMLS65 C2674616, C1868019

Summaries for Attenuated Familial Adenomatous Polyposis

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NIH Rare Diseases:45 Attenuated familial adenomatous polyposis (afap) is an inherited condition that increases the chance to develop cancer of the large intestine (colon) and rectum. it is a milder form of classic familial adenomatous polyposis (fap) and is characterized by fewer colon polyps (an average of 30) and a delay in the development of colon cancer (average age 50 to 55 years). other signs and symptoms may include benign or malignant tumors of the duodenum (a section of the small intestine) and, in rare cases, other symptoms of fap. afap is caused by mutations in the apc gene and is inherited in an autosomal dominant manner. afap is generally managed with regular screening to detect if and when polyps develop. last updated: 4/6/2015

MalaCards based summary: Attenuated Familial Adenomatous Polyposis, also known as attenuated fap, is related to mutyh-related attenuated familial adenomatous polyposis and apc-related attenuated familial adenomatous polyposis. An important gene associated with Attenuated Familial Adenomatous Polyposis is APC (Adenomatous Polyposis Coli), and among its related pathways are Platinum Pathway, Pharmacokinetics/Pharmacodynamics and DNA damage_Role of Brca1 and Brca2 in DNA repair. Affiliated tissues include colon, small intestine and breast, and related mouse phenotypes are mortality/aging and tumorigenesis.

Wikipedia:68 Attenuated familial adenomatous polyposis is a form of familial adenomatous polyposis, a cancer... more...

Related Diseases for Attenuated Familial Adenomatous Polyposis

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Diseases in the Attenuated Familial Adenomatous Polyposis family:

Mutyh-Related Attenuated Familial Adenomatous Polyposis Apc-Related Attenuated Familial Adenomatous Polyposis
Nthl1-Related Attenuated Familial Adenomatous Polyposis Axin2-Related Attenuated Familial Adenomatous Polyposis

Diseases related to Attenuated Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50)    (show all 77)
idRelated DiseaseScoreTop Affiliating Genes
1mutyh-related attenuated familial adenomatous polyposis12.7
2apc-related attenuated familial adenomatous polyposis12.7
3nthl1-related attenuated familial adenomatous polyposis12.7
4axin2-related attenuated familial adenomatous polyposis12.7
5familial adenomatous polyposis11.0
6neuronitis10.3
7myh9-related disorders10.3APC, MUTYH
8gastric cancer, somatic10.2APC, MUTYH
9hyperinsulinism-hyperammonemia syndrome10.2APC, MUTYH
10biliary tract neoplasm10.2APC, MUTYH
11gastrointestinal stromal tumor10.2
12lung cancer10.2
13prostate cancer10.2
14cystinuria10.2
15breast cancer10.2
16melkersson-rosenthal syndrome10.2
17keratitis10.2
18hemophilia b10.2
19cerebral palsy10.2
20nephrolithiasis10.2
21neutropenia10.2
22severe congenital neutropenia10.2
23silicosis10.2
24glomerulosclerosis10.2
25lymphoma10.2
26colitis10.2
27atrial fibrillation10.2
28pre-eclampsia10.2
29fanconi syndrome10.2
30bubonic plague10.2
31arcus senilis10.2
32optic neuritis10.2
33eclampsia10.2
34prostatitis10.2
35neuritis10.2
36melanoma10.2
37hemangiopericytoma10.2
38rhabdomyosarcoma10.2
39ischemia10.2
40cerebritis10.2
41plague10.2
42intussusception10.2
43rosacea10.2
44fasciitis10.2
45hemophilia10.2
46eosinophilic fasciitis10.2
47primary effusion lymphoma10.2
48endotheliitis10.2
49neurofibromatosis, familial spinal10.2APC, MSH6
50cecal disease10.2MSH2, MUTYH

Graphical network of the top 20 diseases related to Attenuated Familial Adenomatous Polyposis:



Diseases related to attenuated familial adenomatous polyposis

Symptoms for Attenuated Familial Adenomatous Polyposis

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Drugs & Therapeutics for Attenuated Familial Adenomatous Polyposis

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Drugs for Attenuated Familial Adenomatous Polyposis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
ErythromycinapprovedPhase 492114-07-812560
Synonyms:
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-14-ethyl-7,12,13-trihydroxy-4-{[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione
,10-dione
114-07-8
3''-O-demethylerythromycin
374700-25-1
45673_FLUKA
45674_FLUKA
79235-06-6
82343-12-2
A/T/S
AC-12744
AC1L1FIQ
AC1L1QK7
AC1L1ZUR
AC1O8PVA
AC1Q2UA1
AC1Q6O1S
AI3-50138
AR-1A4414
AR-1H0723
Abboticin
Abomacetin
Acneryne
Acnesol
Ak-Mycin
Ak-mycin
Akne Cordes Losung
Akne-Mycin
Akne-mycin
Akne-mycin (TN)
Aknederm Ery Gel
Aknemycin
Aknin
AustriaS
BB_NC-1332
BIDD:GT0017
BPBio1_000312
BSPBio_000282
BSPBio_002480
Benzamycin
Benzamycin Pak
Bristamycin
C-Solve-2
C01912
C37H67NO13
CCRIS 9078
CHEBI:42355
CHEMBL532
CID12560
CID3255
CID6713919
CID8233
D00140
DB00199
Del-Mycin
Derimer
Deripil
DivK1c_000294
DivK1c_000397
DivK1c_000702
Dotycin
Dumotrycin
E- mycin, Erycin, Robimysin
E-Base
E-Base (base)
E-Glades
E-Mycin
E-Mycin (base)
E-Solve 2
E.e.s
E.e.s.
E0751
E0774_SIAL
E5389_SIGMA
E6376_SIAL
E7904_SIGMA
EINECS 204-040-1
EM
EMU
ERY
ERYC
ERYC (base)
ERYTHROMYCIN STEARATE
ETS
Emgel
Emu-V
Emu-Ve
Emuvin
Emycin
Endoeritrin
Erecin
Erimycin-T
Erisone
Eritomicina
Eritrocina
Eritromicina
Eritromicina [INN-Spanish]
Ermycin
Eros
Ery
Ery-B
Ery-Diolan
Ery-Sol
Ery-Tab
Ery-Tab (base)
Ery-maxin
Ery-ped
Ery-tab
Eryacne
Eryacnen
Erybid
Eryc
Eryc (TN)
Eryc 125
Eryc Sprinkles
Eryc-125
Eryc-250
Erycen
Erycette
Erycin
Erycinum
Eryderm
Erydermer
Erygel
Erygel (TN)
Eryhexal
Erymax
Erymed
Erypar
Erysafe
Erytab
Erythra-Derm
Erythra-derm
Erythro
Erythro-Statin
Erythro-Teva
Erythrocin
Erythrocin Stearate
Erythroderm
Erythrogran
Erythroguent
Erythromast 36
Erythromid
 
Erythromycin
Erythromycin & VRC3375
Erythromycin (JP15/USP/INN)
Erythromycin A
Erythromycin A, T-Stat, Pantomicina, HSDB 3074, Erytab, DRG-0279
Erythromycin B
Erythromycin Base
Erythromycin Base Base
Erythromycin Base Filmtab
Erythromycin C
Erythromycin Lactate
Erythromycin Ointment
Erythromycin Stearate
Erythromycin [INN:BAN:JAN]
Erythromycin base
Erythromycin estolate
Erythromycin ethylsuccinate
Erythromycin glucoheptonate
Erythromycin intravenous
Erythromycin lactobionate
Erythromycin oxime
Erythromycin sodium lauryl sulfate
Erythromycin, compd. with monododecyl sulfate, sodium salt
Erythromycine
Erythromycine [INN-French]
Erythromycinum
Erythromycinum [INN-Latin]
Erytop
Erytrociclin
Ethril 250
HMS1568O04
HMS1920M04
HMS2091D05
HMS500O16
HSDB 3074
I06-0245
IDI1_000294
IDI1_000397
IDI1_000702
Ilocaps
Ilosone
Ilosone (estolate)
Iloticina
Ilotycin
Ilotycin Gluceptate
Ilotycin T.S
Ilotycin T.S.
Inderm
Inderm Gel
IndermRetcin
KBio1_000294
KBio1_000397
KBio1_000702
KBio2_000555
KBio2_001139
KBio2_003123
KBio2_003707
KBio2_005691
KBio2_006275
KBioGR_001175
KBioSS_000555
KBioSS_001139
KST-1A8261
Kesso-Mycin
LMPK04000006
LS-187077
LS-64648
Latotryd
Lederpax
MLS001066618
Mephamycin
Mercina
MolPort-000-772-161
MolPort-002-507-378
MolPort-003-933-429
N-Methylerythromycin A
NCGC00179619-01
NCI-C55674
NINDS_000294
NINDS_000397
NINDS_000702
NSC 55929
NSC55929
Oftalmolosa Cusi Eritromicina
Oftamolets
PCE Dispertab (base)
Paediathrocin
Pantoderm
Pantodrin
Pantomicina
Pce
Pce (TN)
Pfizer-e
Pharyngocin
Prestwick0_000151
Prestwick1_000151
Prestwick2_000151
Prestwick3_000151
Prestwick_205
Primacine
Propiocine
Proterytrin
R-P Mycin
Retcin
Robimycin
Romycin
SBB057401
SMP1_000119
SMR000544946
SPBio_000778
SPBio_001226
SPBio_002221
SPECTRUM1500280
STK249736
Sans-acne
Sansac
Serp-AFD
Skid Gel E
Spectrum2_000759
Spectrum2_001263
Spectrum4_000538
Spectrum5_001596
Spectrum_000115
Spectrum_000659
Staticin
Staticin (TN)
Stiemicyn
Stiemycin
Sulfuric acid, monododecyl ester, sodium salt, compd. with erythromycin
T-Stat
T-stat (TN)
Taimoxin-F
Theramycin Z
Tiloryth
Tiprocin
Torlamicina
UNII-63937KV33D
Udima Ery Gel
Wemid
Wyamycin S
adecane-2,10-dione (non-preferred name)
bmse000664
erythro
erythromycin
nchembio.285-comp13
2Erythromycin stearatePhase 492
3Anti-Bacterial AgentsPhase 49140
4Erythromycin EthylsuccinatePhase 492
5Gastrointestinal AgentsPhase 46401
6Erythromycin EstolatePhase 492
7Anti-Infective AgentsPhase 417220
8
SulindacapprovedPhase 23538194-50-25352, 1548887
Synonyms:
(E)-(1)-5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-((P-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-((p-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-[[4-(methyl-sulfinyl)phenyl]methylene]-1H-indene-3-acetic acid
(Z)-5-Fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid
2-[(3E)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
2-[(3Z)-6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
2-[6-fluoro-2-methyl-3-[(4-methylsulfinylphenyl)methylidene]inden-1-yl]acetic acid
32004-68-5
38194-50-2
5-Fluoro-2-methyl-1-((4-(methylsulphinyl)phenyl)methylene)-1H-indene-3-acetic acid
53933-60-1
6301-55-9
9000-14-0
AB00513800
AC-4550
AC1L1K5T
AC1LU7GU
AC1LU7GY
AC1Q6YHK
AKOS004119989
AR-1A9609
Aclin
Aflodac
Alphapharm Brand of Sulindac
Apo Sulin
Apo-Sulin
Apotex Brand of Sulindac
Arthrobid
Arthrocine
BB_SC-1128
BPBio1_000315
BRD-A03427350-001-01-3
BRD-A13946108-001-04-9
BRN 2951842
BSPBio_000285
BSPBio_002890
C01531
C20H17FO3S
CAS-38194-50-2
CCRIS 3305
CHEBI:9352
CHEMBL1376
CID1548885
CID1548887
CID5352
CPD000326718
Cahill May Roberts Brand of Sulindac
Chemia Brand of Sulindac
Chibret
Clinoril
Clinoril (TN)
Copal
Copal resin
Copal rosin varnish
Copals
D00120
D013467
DB00605
DivK1c_000601
EINECS 232-527-9
EINECS 250-893-8
EINECS 253-819-2
EINECS 258-873-0
EU-0101070
Gum copal
HMS1568O07
HMS1921C11
HMS2089J04
HMS2092K15
HMS501O03
I06-0523
IDI1_000601
KBio1_000601
KBio2_001506
KBio2_002320
KBio2_004074
KBio2_004888
KBio2_006642
KBio2_007456
KBio3_002110
KBio3_002800
KBioGR_001571
 
KBioGR_002320
KBioSS_001506
KBioSS_002322
KST-1B6530
Kenalin
Kendrick Brand of Sulindac
Klinoril
LS-81610
Lopac-S-8139
Lopac0_001070
MK 231
MK-231
MK231
MLS001056554
MLS001304027
MLS002207124
Merck Brand of Sulindac
Merck Sharp & Dohme Brand of Sulindac
Mobilin
MolPort-002-507-760
MolPort-003-666-287
NCGC00015970-01
NCGC00015970-02
NCGC00015970-03
NCGC00015970-08
NCGC00025268-01
NCGC00025268-02
NCGC00025268-03
NCGC00094349-01
NCGC00094349-02
NINDS_000601
Novo Sundac
Novo-Sundac
Novopharm Brand of Sulindac
Nu Pharm Brand of Sulindac
Nu Sulindac
Nu-Pharm Brand of Sulindac
Nu-Sulindac
Prestwick0_000073
Prestwick1_000073
Prestwick2_000073
Prestwick3_000073
Prestwick_456
Resin copal
S 8139
S2007_Selleck
S4429_SIAL
S8139_SIAL
S8139_SIGMA
SAM002554933
SBB058181
SMR000043852
SMR000326718
SPBio_001451
SPBio_002206
SPECTRUM1500556
STK802068
Spectrum2_001326
Spectrum3_001365
Spectrum4_000876
Spectrum5_001024
Spectrum_001026
Sulindac
Sulindac (JAN/USP/INN)
Sulindac [USAN:BAN:INN:JAN]
Sulindac sulfoxide
Sulindaco
Sulindaco [INN-Spanish]
Sulindacum
Sulindacum [INN-Latin]
Sulindal
Tocris-1707
UNII-184SNS8VUH
UNII-M5221THD3M
UNM-0000306136
Z-5-Fluoro-2-methyl-1-[p-(methlsulfinyl)benzylidene]indene-3-acetic acid
[(1E)-5-fluoro-2-methyl-1-{[4-(methylsulfinyl)phenyl]methylidene}-1H-inden-3-yl]acetic acid
cMAP_000021
cis-5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((P-methylsulfinyl)benzylidene)indene-3-acetic acid
cis-5-Fluoro-2-methyl-1-((p-methylsulfinyl)benzylidene)indene-3-acetic acid
sulindac
{(1E)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
{(1Z)-5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1H-inden-3-yl}acetic acid
{5-fluoro-2-methyl-1-[4-(methylsulfinyl)benzylidene]-1h-inden-3-yl}acetic acid
9
Vitamin Aapproved, nutraceuticalPhase 241311103-57-4, 68-26-8445354
Synonyms:
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol
(2e,4e,6e,8e)-3,7-Dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
.alpha.lin
.alpha.sterol
.beta.-Retinol
11103-57-4
13123-33-6
1341-18-0
1406-67-3
17104-91-5
1rbp
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol
3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer
4-06-00-04133 (Beilstein Handbook Reference)
53637-36-8
5979-23-7
68-26-8
95144_FLUKA
95144_SIGMA
95146_FLUKA
95146_SIGMA
A-Mulsal
A-Sol
A-Vi-Pel
A-Vitan
AC-11701
AC1L9HU3
AC1Q7BU9
ACON
ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1)
AR-1L3057
ATAV
Afaxin
Agiolan
Agoncal
Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol
Alcovit A
All Trans Retinol
All-trans retinol
All-trans-Retinol
Alphalin
Alphasterol
Anatola
Anatola A
Anti-infective vitamin
Antixerophthalmic vitamin
Antixerophthalmisches Vitamin
Aoral
Apexol
Apostavit
Aquasol A
Aquasol A Parenteral
Aquasynth
Atars
Avibon
Avita
Avitol
Axerol
Axerophthol
Axerophtholum
BIDD:PXR0102
BRN 0403040
Bentavit A
Biosterol
C00473
C17276
C20H30O
CCRIS 5444
CHEBI:17336
CHEMBL986
CID445354
Chocola A
Chocola a
Cylasphere
D014801
D06543
DB00162
Del-VI-A
Disatabs Tabs
Dofsol
Dohyfral A
EINECS 200-683-7
EINECS 234-328-2
Epiteliol
HMS1921B04
HMS2092L13
HMS501I08
HSDB 815
Hi-A-Vita
Homagenets Aoral
Homagenets aorl
Hydrovit A
IDI1_000486
LMPR01090001
LPK
LS-1578
Lard Factor
M.V.C. 9+3
M.V.I.-12
 
MLS001066379
MLS001074751
MolPort-001-785-962
Mvc Plus
Myvpack
NCGC00091784-01
NCGC00091784-02
NCGC00091784-03
NCGC00091784-04
NCGC00091784-05
NCGC00091784-06
NSC 122759
NSC122759
Nio-A-Let
Oleovitamin A
Ophthalamin
Plivit A
Prepalin
R7632_SIGMA
Retin-11,12-t2-ol (9CI)
Retinol
Retinol [INN:BAN]
Retinol solution
Retinol, all-trans- (8CI)
Retinol-(cellular-retinol-binding-protein)
Retinolo
Retinolo [DCIT]
Retinolum
Retinolum [INN-Latin]
Retrovitamin A
Ro-a-vit
Rovimix A 500
SDCCGMLS-0066724.P001
SMP2_000102
SMR000112036
SPECTRUM1501203
ST057232
Sehkraft A
Solu-A
Spectrum5_000993
Spectrum5_001997
Super A
Testavol
Testavol S
Thalasphere
UNII-81G40H8B0T
UNII-G2SH0XKK91
Vaflol
Vafol
Veroftal
Vi-.alpha.
Vi-Alpha
Vi-Dom-A
Vi-a
Vio-A
Vitamin A
Vitamin A (Feed)
Vitamin A (USP)
Vitamin A alcohol
Vitamin A alcohol (VAN)
Vitamin A cryst
Vitamin A palmitate
Vitamin A1
Vitamin A1 alcohol
Vitamin A1 alcohol, all trans
Vitamin a
Vitamin- A
Vitamin- A alcohol
Vitamin- A alcohol solution
Vitamin- A1
Vitamin-?A
Vitamin-?A alcohol
Vitamin-?A alcohol solution
Vitamin-?A1
Vitamine A
Vitaminum A
Vitavel A
Vitavel-A
Vitpex
Vogan
Vogan-Neu
Vogan-nu
WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U2Q C1 C1
Wachstumsvitamin
ZINC03831417
Zinosan N
[11,12-3H]-Retinol
alin
all-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol
all-trans-Retinol
all-trans-Retinyl alcohol
all-trans-Vitamin A
all-trans-Vitamin A alcohol
all-trans-Vitamin A1
all-trans-retinol
all-trans-retinyl alcohol
all-trans-vitamin A alcohol
b-Retinol
beta-Retinol
retinol
tROL
trans-Retinol
trans-Retinol acid (Vitamin A)
trans-Vitamin A alcohol
trans-retinol
10
Erlotinib HydrochloridePhase 2781183319-69-9176871
Synonyms:
 
erlotinib hydrochloride
11Peripheral Nervous System AgentsPhase 218510
12Retinol palmitatePhase 2413
13Cyclooxygenase InhibitorsPhase 22225
14Protein Kinase InhibitorsPhase 23162
15Anti-Inflammatory Agents, Non-SteroidalPhase 23549
16Anti-Inflammatory AgentsPhase 28478
17Analgesics, Non-NarcoticPhase 25184
18Contraceptives, OralPhase 23734
19Antirheumatic AgentsPhase 28496
20AnalgesicsPhase 29358
21ColaNutraceuticalPhase 21768
22retinolNutraceuticalPhase 2413

Interventional clinical trials:

idNameStatusNCT IDPhase
1Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutations in Familial Adenomatous PolyposisRecruitingNCT02175914Phase 4
2Erythromycin Treatment for Readthrough of APC Gene Stop Codon Mutation in Familial Adenomatous Polyposis-minors' Adjusted VersionNot yet recruitingNCT02354560Phase 4
3A Clinical Trial of COX and EGFR Inhibition in Familial Polyposis PatientsActive, not recruitingNCT01187901Phase 2
4Non-Surgical Management of Attenuated and Deleterious (Classical) Familial Adenomatous Polyposis: A Long-term Surveillance ProgramRecruitingNCT02747862

Search NIH Clinical Center for Attenuated Familial Adenomatous Polyposis

Genetic Tests for Attenuated Familial Adenomatous Polyposis

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Genetic tests related to Attenuated Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Attenuated Fap22

Anatomical Context for Attenuated Familial Adenomatous Polyposis

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MalaCards organs/tissues related to Attenuated Familial Adenomatous Polyposis:

33
Colon, Small intestine, Breast, Brain, T cells, Temporal lobe

Animal Models for Attenuated Familial Adenomatous Polyposis or affiliated genes

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MGI Mouse Phenotypes related to Attenuated Familial Adenomatous Polyposis:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00107687.2APC, APEX1, MSH2, MSH6, MUTYH, OGG1
2MP:00020067.0APC, APEX1, MSH2, MSH6, MUTYH, NUDT1
3MP:00053846.7APC, APEX1, MSH2, MSH6, MUTYH, NUDT1
4MP:00053766.4APC, APEX1, MSH2, MSH6, MUTYH, NUDT1

Publications for Attenuated Familial Adenomatous Polyposis

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Articles related to Attenuated Familial Adenomatous Polyposis:

(show all 42)
idTitleAuthorsYear
1
Association of the -262C/T polymorphism in the catalase gene promoter and the C242T polymorphism of the NADPH oxidase P22phox gene with essential arterial hypertension in patients with diabetes mellitus type 2. (23701472)
2014
2
Studies of genes involved in craniofacial development and tumorigenesis: FGF3 contributes to isolated oral clefts and may interact with PAX9. (24697712)
2014
3
Serum autoantibody profiles of IgA, IgE and IgM in canine pemphigus foliaceus. (24975693)
2014
4
Expressional analysis of the astrocytic Kir4.1 channel in a pilocarpine-induced temporal lobe epilepsy model. (23922547)
2013
5
Impact of genetic SLC28 transporter and ITPA variants on ribavirin serum level, hemoglobin drop and therapeutic response in patients with HCV infection. (23195617)
2013
6
Fabry disease: a rare cause of Fever of unknown origin. (22177449)
2012
7
Transcription factor 7-like 2 (TCF7L2) gene polymorphism and complication/comorbidity profile in type 2 diabetes patients. (21641671)
2011
8
Single-stage operation for giant substernal goiter with severe coronary artery disease. (21881378)
2011
9
GJB2 allele variants and the associated audiologic features identified in Chinese patients with less severe idiopathic hearing loss. (21366436)
2011
10
Spheroid-forming subpopulation of breast cancer cells demonstrates vasculogenic mimicry via hsa-miR-299-5p regulated de novo expression of osteopontin. (19538464)
2010
11
Columnar cell lesions of the canine mammary gland: pathological features and immunophenotypic analysis. (20178635)
2010
12
Characterisation and utility of thiopurine methyltransferase and thiopurine metabolite measurements in autoimmune hepatitis. (19906459)
2010
13
Dehydroepiandrosterone ameliorates hepatocellular damage in obstructive jaundice. (20803708)
2010
14
Rapid functional screening of effective siRNAs against Plk1 and its growth inhibitory effects in laryngeal carcinoma cells. (21189159)
2010
15
The DRD4 receptor Exon 3 VNTR and 5' SNP variants and mRNA expression in human post-mortem brain tissue. (20468066)
2010
16
A novel PAX6 mutation in a large Chinese family with aniridia and congenital cataract. (20664694)
2010
17
Surveillance to detect chronic wasting disease in white-tailed deer in Wisconsin. (19901375)
2009
18
Analysis of single nucleotide polymorphisms of CRYGA and CRYGB genes in control population of western Indian origin. (19384013)
2009
19
The development of antisocial behavior: psychobiological and environmental factors and gene-environment interactions]. (19226487)
2009
20
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. (17767165)
2007
21
Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay. (17011540)
2007
22
Free radicals and antioxidants in normal physiological functions and human disease. (16978905)
2007
23
A comparison of hang-back with conventional recession surgery for exotropia. (17920319)
2007
24
Progression of progressive multifocal leukoencephalopathy despite treatment with beta-interferon. (16769975)
2006
25
Nef is physically recruited into the immunological synapse and potentiates T cell activation early after TCR engagement. (16237100)
2005
26
Another chromosomal locus for mitral valve prolapse: close but no cigar. (16186433)
2005
27
Magnetic resonance imaging of choroidal inflammation in Vogt-Koyanagi-Harada disease. (15662244)
2004
28
The correlation between neck lymphy node metastasis and matrixmetalloproteinase-2 expression at the invasive tumor front of oral squamous cell carcinomas]. (15190788)
2004
29
Implications of serum TNF-beta and IL-13 in the treatment response of childhood nephrotic syndrome. (12697154)
2003
30
Lymphocytic vasculitis associated with the anthrax vaccine: case report and review of anthrax vaccination. (14585454)
2003
31
Professor Ouyang Heng's experience in treating neurodermatitis. (14535180)
2003
32
A novel keratin 5 mutation (K5V186L) in a family with EBS-K: a conservative substitution can lead to development of different disease phenotypes. (11407988)
2001
33
Effects of galanin receptor agonists on locus coeruleus neurons. (11689176)
2001
34
Pharmacology and clinical experience with saquinavir. (11336588)
2001
35
The presence of soluble c-erbB-2 in saliva and serum among women with breast carcinoma: a preliminary study. (10873088)
2000
36
Inflammatory cells and mediators in bronchial lavage of patients with chronic obstructive pulmonary disease. (9727789)
1998
37
Decreased expression of cold-inducible RNA-binding protein (CIRP) in male germ cells at elevated temperature. (9422546)
1998
38
Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15. (9428629)
1997
39
Malignant occipital astrocytoma in a patient with Lhermitte-Duclos disease (cerebellar dysplastic gangliocytoma). (8672269)
1996
40
Sensitivity of opioid receptor binding to N-substituted maleimides and methanethiosulfonate derivatives. (8947919)
1996
41
Regulation of IL-4 and IL-5 secretion by histamine and PGE2. (8644511)
1995
42
Cortical stimulation induces Fos expression in striatal neurons via NMDA glutamate and dopamine receptors. (8624698)
1995

Variations for Attenuated Familial Adenomatous Polyposis

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Expression for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Search GEO for disease gene expression data for Attenuated Familial Adenomatous Polyposis.

Pathways for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Pathways related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 11)
idSuper pathwaysScoreTop Affiliating Genes
19.4MSH2, MSH6
29.4MSH2, MSH6
3
Show member pathways
9.4MSH2, MSH6
4
Show member pathways
9.3APEX1, MSH2
5
Show member pathways
9.2MUTYH, OGG1
69.1APC, MSH2, MSH6
7
Show member pathways
9.1APC, MSH2, MSH6
89.1APC, MSH2, MSH6
9
Show member pathways
8.6APEX1, MUTYH, OGG1
10
Show member pathways
8.0APEX1, MSH2, MSH6, OGG1
11
Show member pathways
7.6APEX1, MSH2, MSH6, MUTYH, OGG1

GO Terms for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Biological processes related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1depurinationGO:00450079.5MUTYH, OGG1
2negative regulation of DNA recombinationGO:00459109.3MSH2, MSH6
3base-excision repairGO:00062849.0APEX1, OGG1

Molecular functions related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1guanine/thymine mispair bindingGO:003213710.1MSH2, MSH6
2single thymine insertion bindingGO:003214310.0MSH2, MSH6
3ADP bindingGO:00435319.8MSH2, MSH6
4double-stranded DNA bindingGO:00036909.5MSH2, MSH6
5damaged DNA bindingGO:00036849.5APEX1, OGG1
6DNA bindingGO:00036778.4APEX1, MSH2, MSH6, MUTYH

Sources for Attenuated Familial Adenomatous Polyposis

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet