MCID: ATT003
MIFTS: 49

Attenuated Familial Adenomatous Polyposis malady

Genetic diseases, Rare diseases, Gastrointestinal diseases, Cancer diseases categories

Aliases & Classifications for Attenuated Familial Adenomatous Polyposis

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Sources:
42NIH Rare Diseases, 20GeneTests, 48Orphanet, 22GTR, 61UMLS, 34MESH via Orphanet, 26ICD10 via Orphanet, 62UMLS via Orphanet
See all sources

Aliases & Descriptions for Attenuated Familial Adenomatous Polyposis:

Name: Attenuated Familial Adenomatous Polyposis 42 48
Attenuated Fap 42 20 48 22
Attenuated Adenomatous Polyposis Coli 42 22
Attenuated Familial Polyposis Coli 42 48
Afap 42 48
 
Familial Adenomatous Polyposis, Attenuated 61
Adenomatous Polyposis Coli, Attenuated 61
Mild Form of Fap 42
Aapc 42


Classifications:



Characteristics (Orphanet epidemiological data):

48
attenuated fap:
Inheritance: Autosomal dominant,Autosomal recessive; Age of onset: Adult


External Ids:

Orphanet48 220460
MESH via Orphanet34 C538265
ICD10 via Orphanet26 D12.6
UMLS via Orphanet62 C2674616

Summaries for Attenuated Familial Adenomatous Polyposis

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NIH Rare Diseases:42 Attenuated familial adenomatous polyposis (afap) is an inherited condition that causes cancer of the large intestine (colon) and rectum. it is a milder form of classic familial adenomatous polyposis that is characterized by fewer colon polyps (an average of 30) and a delay in the development of colon cancer (average age 50 to 55 years). other signs and symptoms may include dental abnormalities; desmoid tumors; and benign and malignant (cancerous) tumors of the duodenum (a section of the small intestine), stomach, bones, skin, thyroid and other tissues. afap is caused by mutations in the apc gene and is inherited in an autosomal dominant manner. afap is generally managed with regular screening to detect if and when polyps develop. last updated: 11/28/2014

MalaCards based summary: Attenuated Familial Adenomatous Polyposis, also known as attenuated fap, is related to adenomatous polyposis coli and colorectal cancer. An important gene associated with Attenuated Familial Adenomatous Polyposis is MUTYH (mutY homolog), and among its related pathways are Depurination and Busulfan Pathway, Pharmacodynamics. The compounds af/ap and 8-hydroxyguanine have been mentioned in the context of this disorder. Affiliated tissues include colon, bone and small intestine, and related mouse phenotypes are muscle and liver/biliary system.

Wikipedia:64 Attenuated familial adenomatous polyposis is a form of familial adenomatous polyposis, a cancer... more...

Related Diseases for Attenuated Familial Adenomatous Polyposis

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Diseases in the Attenuated Familial Adenomatous Polyposis family:

Mutyh-Related Attenuated Familial Adenomatous Polyposis Apc-Related Attenuated Familial Adenomatous Polyposis
Axin2-Related Attenuated Familial Adenomatous Polyposis

Diseases related to Attenuated Familial Adenomatous Polyposis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
idRelated DiseaseScoreTop Affiliating Genes
1adenomatous polyposis coli31.1APC, CTNNB1
2colorectal cancer30.9APC, CTNNB1
3muir-torre syndrome30.8MSH2, MSH6
4adenocarcinoma29.1PTGS2, APEX1, APC, MSH6, MSH2, OGG1
5adenoma28.6PTGS2, APEX1, APC, MUTYH, MSH6, MSH2
6mutyh-related attenuated familial adenomatous polyposis10.6
7apc-related attenuated familial adenomatous polyposis10.6
8axin2-related attenuated familial adenomatous polyposis10.6
9polyposis, juvenile intestinal10.5APC
10duodenitis10.4
11familial gastric cancer10.4
12gastric cancer, somatic10.3APC, MUTYH
13adenomas, multiple colorectal10.1
14ectodermal dysplasia10.1
15mismatch repair cancer syndrome10.1MSH6, MSH2
16lynch syndrome10.1MSH6, MSH2
17medulloblastoma10.1APC, CTNNB1
18hepatocellular adenoma10.1CTNNB1, APC
19barrett esophagus/esophageal adenocarcinoma10.1APC, PTGS2
20desmoid disease, hereditary10.1APC, CTNNB1
21fibromatosis10.1APC, CTNNB1
22peutz-jeghers syndrome10.0APC, CTNNB1
23neurofibromatosis10.0MSH6, MSH2
24skin benign neoplasm10.0MSH2, MSH6
25xeroderma pigmentosum, variant type10.0OGG1, APEX1
26bladder cancer, somatic9.9OGG1, APEX1, PTGS2
27ulcerative colitis9.9MSH2, APC, APEX1
28adrenal cortical adenoma9.9APC, CTNNB1
29hepatoblastoma9.9CTNNB1, APC
30lung cancer9.9OGG1, APEX1, PTGS2
31brain cancer9.9MSH2, MSH6, APC
32intestinal neoplasm9.9PTGS2, APC, CTNNB1
33cervical cancer, somatic9.9PTGS2, APEX1, MSH2
34gastric adenocarcinoma9.9PTGS2, APC, CTNNB1
35breast cancer9.9PTGS2, APC, CTNNB1
36rectal neoplasm9.8APC, MUTYH, MSH6, MSH2
37lung cancer susceptibility 39.8PTGS2, OGG1, CTNNB1
38stomach cancer9.8PTGS2, APC, CTNNB1
39endometrial cancer9.7MSH6, MSH2, CTNNB1
40leukemia9.6OGG1, MSH2, APEX1, NUDT1
41hepatocellular carcinoma9.6PTGS2, APC, MUTYH, OGG1, CTNNB1
42pancreatic cancer9.6PTGS2, APEX1, MSH2, CTNNB1
43ovarian cancer, somatic9.5PTGS2, MSH6, MSH2, CTNNB1
44tongue squamous cell carcinoma9.2PTGS2, APEX1, APC, MSH2, OGG1, CTNNB1
45prostate cancer9.0PTGS2, APEX1, APC, MSH6, MSH2, OGG1

Graphical network of the top 20 diseases related to Attenuated Familial Adenomatous Polyposis:



Diseases related to attenuated familial adenomatous polyposis

Symptoms for Attenuated Familial Adenomatous Polyposis

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Drugs & Therapeutics for Attenuated Familial Adenomatous Polyposis

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Drug clinical trials:

Search ClinicalTrials for Attenuated Familial Adenomatous Polyposis

Search NIH Clinical Center for Attenuated Familial Adenomatous Polyposis

Genetic Tests for Attenuated Familial Adenomatous Polyposis

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Genetic tests related to Attenuated Familial Adenomatous Polyposis:

id Genetic test Affiliating Genes
1 Attenuated Fap20 22
2 Adenomatous Polyposis Coli, Attenuated22

Anatomical Context for Attenuated Familial Adenomatous Polyposis

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MalaCards organs/tissues related to Attenuated Familial Adenomatous Polyposis:

31
Colon, Bone, Small intestine, Thyroid, Skin, Pancreas, Testes

Animal Models for Attenuated Familial Adenomatous Polyposis or affiliated genes

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MGI Mouse Phenotypes related to Attenuated Familial Adenomatous Polyposis:

35 (show all 13)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053698.3CTNNB1, APC, PTGS2, APEX1
2MP:00053708.0PTGS2, CTNNB1, OGG1, APC, APEX1
3MP:00053818.0PTGS2, APC, CTNNB1, MSH2
4MP:00028737.9CTNNB1, OGG1, APC, APEX1, PTGS2
5MP:00053867.7PTGS2, APC, OGG1, NUDT1, CTNNB1
6MP:00107717.7APC, PTGS2, MSH6, MSH2, CTNNB1
7MP:00053977.5NUDT1, PTGS2, APC, MSH2, OGG1, CTNNB1
8MP:00036317.2OGG1, MSH2, MUTYH, APC, PTGS2, NUDT1
9MP:00053877.1MSH2, NUDT1, PTGS2, APEX1, APC, OGG1
10MP:00107686.6OGG1, MSH2, MSH6, MUTYH, APC, PTGS2
11MP:00020066.3PTGS2, APEX1, APC, NUDT1, MUTYH, MSH2
12MP:00053846.3NUDT1, PTGS2, APEX1, MSH2, APC, MSH6
13MP:00053766.3OGG1, NUDT1, PTGS2, APEX1, APC, MUTYH

Publications for Attenuated Familial Adenomatous Polyposis

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Articles related to Attenuated Familial Adenomatous Polyposis:

(show all 42)
idTitleAuthorsYear
1
Identification of an APC Variant in a Patient with Clinical Attenuated Familial Adenomatous Polyposis. (24790607)
2014
2
Attenuated familial adenomatous polyposis manifests as autosomal dominant late-onset colorectal cancer. (24549056)
2014
3
A Novel Germline Mutation in Exon 15 of the APC Gene in Attenuated Familial Adenomatous Polyposis: A Report of Two Cases. (23423322)
2013
4
Colon cancer prevention by detection of APC gene mutation in a family with attenuated familial adenomatous polyposis. (23244118)
2012
5
Hepatocelluar carcinoma associated with attenuated familial adenomatous polyposis: a case report and review of the literature. (21813337)
2012
6
First large rearrangement in the MUTYH gene and attenuated familial adenomatous polyposis syndrome. (21815886)
2011
7
Total gastrectomy and pancreaticoduodenectomy for gastric polyposis and duodenal ampullary adenoma in a patient with attenuated familial adenomatous polyposis. (21375864)
2011
8
Attenuated familial adenomatous polyposis: results from an international collaborative study. (20105204)
2010
9
A distinct mutation on the alternative splice site of APC exon 9 results in attenuated familial adenomatous polyposis phenotype. (20033787)
2010
10
Identification of 5 novel germline APC mutations and characterization of clinical phenotypes in Japanese patients with classical and attenuated familial adenomatous polyposis. (21078199)
2010
11
Total gastrectomy for gastric dysplasia in a patient with attenuated familial adenomatous polyposis syndrome. (18640943)
2008
12
Nine-year follow-up of a patient with attenuated familial adenomatous polyposis treated with cyclo-oxygenase-2 inhibitors. (18609144)
2008
13
American founder mutation for attenuated familial adenomatous polyposis. (18063416)
2008
14
Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis. (18166348)
2008
15
Heterogeneous molecular mechanisms underlie attenuated familial adenomatous polyposis. (18091433)
2007
16
A splice-site mutation in exon 4 of the APC gene in a family with attenuated familial adenomatous polyposis. (17410430)
2007
17
Variable phenotypic expression of identical MYH germline mutations in siblings with attenuated familial adenomatous polyposis. (18186383)
2007
18
Germline mutations in APC and MUTYH are responsible for the majority of families with attenuated familial adenomatous polyposis. (17489848)
2007
19
Constitutional high expression of an APC mRNA isoform in a subset of attenuated familial adenomatous polyposis patients. (17143620)
2007
20
Variation of a variation: case report of attenuated familial adenomatous polyposis. (18333267)
2006
21
Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation. (16461775)
2006
22
Gastric carcinogenesis after long-term observation of clinical course without any treatment in a patient with attenuated familial adenomatous polyposis. (16873575)
2006
23
Attenuated familial adenomatous polyposis: a case report with mixed features and review of genotype-phenotype correlation. (16253019)
2005
24
Stability of colon stem cell methylation after neo-adjuvant therapy in a patient with attenuated familial adenomatous polyposis. (15941485)
2005
25
Attenuated familial adenomatous polyposis and Muir-Torre syndrome linked to compound biallelic constitutional MYH gene mutations. (16207212)
2005
26
Intraductal papillary mucinous neoplasm of the pancreas in a patient with attenuated familial adenomatous polyposis. (15623495)
2005
27
Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. (15300576)
2004
28
Attenuated familial adenomatous polyposis (AFAP). A review of the literature. (14574166)
2003
29
A predominant increase in the APC gene isoform with exon 9a in a case of attenuated familial adenomatous polyposis. (12519375)
2003
30
Attenuated familial adenomatous polyposis presenting as ampullary adenocarcinoma. (12740351)
2003
31
Attenuated familial adenomatous polyposis: an evolving and poorly understood entity. (11786778)
2002
32
Challenge in the differentiation between attenuated familial adenomatous polyposis and hereditary nonpolyposis colorectal cancer: case report with review of the literature. (12135043)
2002
33
High-magnification-chromoscopic-colonoscopy: a role for screening and treatment in attenuated familial adenomatous polyposis? (12164972)
2002
34
Effect of sulindac treatment for attenuated familial adenomatous polyposis with a new germline APC mutation at codon 161: report of a case. (12394442)
2002
35
Fundic gland polyposis with high-grade dysplasia in a child with attenuated familial adenomatous polyposis and familial gastric cancer. (11321399)
2001
36
Attenuated familial adenomatous polyposis associated with advanced rectal cancer in a 16-year-old boy: report of a case. (11766074)
2001
37
Inactivation of germline mutant APC alleles by attenuated somatic mutations: a molecular genetic mechanism for attenuated familial adenomatous polyposis. (10924409)
2000
38
Giant fundic polyp complicating attenuated familial adenomatous polyposis. (10925993)
2000
39
Attenuated familial adenomatous polyposis in a man with an interstitial deletion of chromosome arm 5q. (10494086)
1999
40
A family with attenuated familial adenomatous polyposis due to a mutation in the alternatively spliced region of APC exon 9. (9603437)
1998
41
Attenuated familial adenomatous polyposis due to a mutation in the 3' part of the APC gene. A clue for understanding the function of the APC protein. (8655134)
1996
42
Attenuated familial adenomatous polyposis (AFAP). A phenotypically and genotypically distinctive variant of FAP. (8625067)
1995

Variations for Attenuated Familial Adenomatous Polyposis

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Clinvar genetic disease variations for Attenuated Familial Adenomatous Polyposis:

5
id Gene Variation Type Significance SNP ID Assembly Location
1MUTYHNM_001128425.1(MUTYH): c.1228_1229insGG (p.Glu410Glyfs)insertionPathogenicGRCh37Chr 1, 45797186: 45797187
2MUTYHMUTYH, EX3-6DELdeletionPathogenic
3MUTYHNM_001128425.1(MUTYH): c.1418C> A (p.Ala473Asp)single nucleotide variantPathogenicrs200844166GRCh37Chr 1, 45796912: 45796912
4MUTYHNM_001128425.1(MUTYH): c.1461delC (p.Thr488Profs)deletionPathogenicGRCh37Chr 1, 45796869: 45796869
5MUTYHNM_001128425.1(MUTYH): c.312C> A (p.Tyr104Ter)single nucleotide variantPathogenicrs121908380GRCh37Chr 1, 45799121: 45799121
6MUTYHNM_001128425.1(MUTYH): c.1438G> T (p.Glu480Ter)single nucleotide variantPathogenicrs121908381GRCh37Chr 1, 45796892: 45796892

Expression for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Search GEO for disease gene expression data for Attenuated Familial Adenomatous Polyposis.

Pathways for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Pathways related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 20)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.7OGG1, MUTYH
2
Show member pathways
Catalytic cycle of mammalian FMOs36
9.4MSH2, APEX1
39.3MSH6, MSH2
4
Show member pathways
9.3MSH2, MSH6
5
Show member pathways
9.3MSH2, MSH6
6
Show member pathways
9.3APEX1, MUTYH, OGG1
7
Show member pathways
9.3APEX1, MUTYH, OGG1
89.3CTNNB1, APC
99.3CTNNB1, APC
10
Show member pathways
9.3CTNNB1, APC
119.2APEX1, CTNNB1
129.1CTNNB1, PTGS2
13
Show member pathways
8.9OGG1, MSH2, MSH6
148.8PTGS2, APC, CTNNB1
158.8CTNNB1, APC, PTGS2
16
Show member pathways
8.6MSH2, MSH6, MUTYH, APEX1
178.5CTNNB1, MSH2, MSH6
18
Show member pathways
Signal transduction PTEN pathway59
8.1APC, MSH6, MSH2, CTNNB1
197.6PTGS2, APC, MSH6, MSH2, CTNNB1
207.6CTNNB1, MSH2, MSH6, APC, PTGS2

Compounds for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Compounds related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show top 50)    (show all 62)
idCompoundScoreTop Affiliating Genes
1af/ap4410.2APC, MUTYH
28-hydroxyguanine4410.1OGG1, MUTYH
32-deoxyribonolactone4410.0APEX1, OGG1
4dihydrouracil44 2411.0APEX1, OGG1
5thymine glycol449.9APEX1, OGG1
68-oxo-dgtp44 2410.8NUDT1, OGG1, MUTYH
7piroxicam44 1110.8PTGS2, APC
8phosphodiester449.7OGG1, APEX1
9methylazoxymethanol acetate449.7CTNNB1, APC
101-hydroxyanthraquinone449.7APC, CTNNB1
11pyrimidine44 2410.7APEX1, OGG1, MUTYH
12samp449.7APC, CTNNB1
13thymine44 2410.7APC, OGG1, APEX1
141,2-dimethylhydrazine449.6CTNNB1, APC
15methylmethanesulfonate449.6OGG1, APC, APEX1
16purine44 2410.6OGG1, APEX1, NUDT1
17azoxymethane449.6CTNNB1, APC
18cytosine44 2410.6APEX1, APC, OGG1
192-amino-3-methylimidazo(4,5-f)quinoline449.6CTNNB1, APC
20sodium bisulfite449.5APC, CTNNB1
21mnng449.5APC, MSH2
22nimesulide44 1110.4CTNNB1, PTGS2
238-oxo-dg449.4MUTYH, APEX1, NUDT1, OGG1
24mononucleotide449.4APC, MSH6, MSH2
25etodolac44 1110.3PTGS2, CTNNB1
26benzene449.3APEX1, OGG1
27rofecoxib44 50 28 1112.3CTNNB1, PTGS2
28exisulind449.2CTNNB1, APC, PTGS2
29phip449.2CTNNB1, APC
30sulindac44 1110.2CTNNB1, PTGS2, APC
31celecoxib44 60 28 50 24 1114.1CTNNB1, APC, PTGS2
32mannitol44 1110.1OGG1, APEX1, CTNNB1
338-oxoguanine449.0MUTYH, APC, NUDT1, OGG1, APEX1
34curcumin449.0APC, CTNNB1, PTGS2
35guanine44 24 1111.0MUTYH, OGG1, CTNNB1, APC
36o6-methylguanine448.9APC, MSH2, MSH6, APEX1
37n-methyl-n-nitrosourea448.9CTNNB1, MSH2, MSH6
38dopamine44 28 24 1111.8APC, OGG1, CTNNB1, NUDT1
39aspirin44 50 28 2411.8APC, PTGS2, CTNNB1
40biotin44 24 1110.8MSH2, MSH6, CTNNB1
41oxygen44 249.8PTGS2, OGG1, MUTYH, NUDT1, APEX1
42oligonucleotide448.6OGG1, CTNNB1, APC, APEX1
43crcs448.6CTNNB1, MSH2, MSH6, APC
44h2o2448.5CTNNB1, OGG1, MUTYH, APEX1, NUDT1
45adenine44 24 1110.4OGG1, MSH2, MUTYH, APC, APEX1, NUDT1
46atp44 289.2MSH2, OGG1, APEX1, CTNNB1, NUDT1
47glutamate448.2OGG1, APEX1, CTNNB1, MSH2
48paraffin448.1APEX1, CTNNB1, MSH2, MSH6, APC
49serine447.7CTNNB1, OGG1, MSH6, MSH2, APEX1, APC
50cisplatin44 50 60 1110.7CTNNB1, MSH2, MSH6, MUTYH, APEX1, PTGS2

GO Terms for genes affiliated with Attenuated Familial Adenomatous Polyposis

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Cellular components related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1MutSalpha complexGO:00323019.6MSH2, MSH6
2nuclear chromosomeGO:00002289.5MSH2, MSH6
3beta-catenin destruction complexGO:00308779.5APC, CTNNB1
4cell-cell adherens junctionGO:00059139.4CTNNB1, APC
5lateral plasma membraneGO:00163289.3APC, CTNNB1
6centrosomeGO:00058138.8CTNNB1, APC, APEX1
7mitochondrionGO:00057398.6NUDT1, APEX1, MUTYH, OGG1
8nucleoplasmGO:00056548.4APEX1, MUTYH, OGG1, CTNNB1
9cytoplasmGO:00057377.4CTNNB1, MSH6, APC, APEX1, PTGS2, NUDT1
10nucleusGO:00056346.9NUDT1, PTGS2, APEX1, APC, MUTYH, MSH6

Biological processes related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 27)
idNameGO IDScoreTop Affiliating Genes
1depurinationGO:004500710.1OGG1, MUTYH
2base-excision repair, AP site formationGO:000628510.0MUTYH, OGG1
3DNA catabolic process, endonucleolyticGO:00007379.8APEX1, OGG1
4nucleic acid phosphodiester bond hydrolysisGO:00903059.7OGG1, APEX1
5meiotic mismatch repairGO:00007109.7MSH6, MSH2
6somatic recombination of immunoglobulin gene segmentsGO:00164479.7MSH6, MSH2
7base-excision repairGO:00062849.7MUTYH, OGG1, APEX1
8maintenance of DNA repeat elementsGO:00435709.7MSH2, MSH6
9positive regulation of helicase activityGO:00510969.6MSH2, MSH6
10negative regulation of DNA recombinationGO:00459109.6MSH2, MSH6
11canonical Wnt signaling pathway involved in negative regulation of apoptotic processGO:00443369.6APC, CTNNB1
12somatic hypermutation of immunoglobulin genesGO:00164469.6MSH2, MSH6
13determination of adult lifespanGO:00083409.6MSH2, MSH6
14isotype switchingGO:00451909.6MSH2, MSH6
15response to oxidative stressGO:00069799.5OGG1, NUDT1, PTGS2
16proximal/distal pattern formationGO:00099549.5APC, CTNNB1
17T cell differentiation in thymusGO:00330779.4APC, CTNNB1
18thymus developmentGO:00485389.3APC, CTNNB1
19ATP catabolic processGO:00062009.2MSH6, NUDT1, MSH2
20cellular component disassembly involved in execution phase of apoptosisGO:00069219.2APC, CTNNB1
21cellular response to mechanical stimulusGO:00712609.1CTNNB1, PTGS2
22response to estradiolGO:00323559.1PTGS2, OGG1, CTNNB1
23mismatch repairGO:00062989.0MSH2, NUDT1, MUTYH, MSH6
24positive regulation of apoptotic processGO:00430658.8PTGS2, APC, CTNNB1
25response to drugGO:00424938.6OGG1, APEX1, PTGS2, CTNNB1
26DNA repairGO:00062818.5MSH2, APEX1, MUTYH, MSH6, OGG1
27negative regulation of cell proliferationGO:00082858.5CTNNB1, APC, PTGS2

Molecular functions related to Attenuated Familial Adenomatous Polyposis according to GeneCards Suite gene sharing:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1endonuclease activityGO:00045199.7OGG1, APEX1
2single thymine insertion bindingGO:00321439.6MSH2, MSH6
3oxidized purine DNA bindingGO:00323579.6MSH6, MSH2
4damaged DNA bindingGO:00036849.6OGG1, APEX1
5single guanine insertion bindingGO:00321429.6MSH6, MSH2
6guanine/thymine mispair bindingGO:00321379.6MSH6, MSH2
7four-way junction DNA bindingGO:00004009.6MSH6, MSH2
8mismatched DNA bindingGO:00309839.5MSH2, MSH6
9cadherin bindingGO:00452969.5CTNNB1, APC
10ADP bindingGO:00435319.4MSH2, MSH6
11DNA-dependent ATPase activityGO:00080949.3MSH2, MSH6
12MutLalpha complex bindingGO:00324059.3MSH2, MSH6, MUTYH
13double-stranded DNA bindingGO:00036908.8CTNNB1, MSH2, MSH6
14enzyme bindingGO:00198998.7PTGS2, MSH2, CTNNB1
15protein kinase bindingGO:00199018.6APC, MSH2, CTNNB1
16protein bindingGO:00055156.6APEX1, APC, MUTYH, MSH6, MSH2, OGG1

Sources for Attenuated Familial Adenomatous Polyposis

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2CDC
12ExPASy
13FDA
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
33MeSH
34MESH via Orphanet
35MGI
38NCI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
57SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet