MCID: ATY003
MIFTS: 28

Atypical Autism

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Atypical Autism

MalaCards integrated aliases for Atypical Autism:

Name: Atypical Autism 12 55 14 69
Pdd 12

Classifications:

Orphanet: 55  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060042
Orphanet 55 ORPHA199627
UMLS via Orphanet 70 C0338986
ICD10 via Orphanet 33 F84.1
ICD10 32 F84.1
UMLS 69 C0338986

Summaries for Atypical Autism

Disease Ontology : 12 An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.

MalaCards based summary : Atypical Autism, also known as pdd, is related to pervasive developmental disorder and asperger syndrome. An important gene associated with Atypical Autism is PDP1 (Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1). Affiliated tissues include temporal lobe, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Atypical Autism

Diseases related to Atypical Autism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 pervasive developmental disorder 31.1 NLGN3 NLGN4X OXTR
2 asperger syndrome 28.7 NLGN3 NLGN4X OXTR
3 camurati-engelmann disease 11.3
4 mental retardation, autosomal dominant 26 10.3
5 autism 10.2
6 tuberous sclerosis 9.7
7 neurofibromatosis, type iv, of riccardi 9.6
8 arteriovenous malformation 9.6
9 epilepsy 9.6
10 central nervous system disease 9.6
11 nervous system disease 9.6
12 chromosome 15q duplication 9.6
13 ring chromosome 17 9.6
14 autism spectrum disorder 9.2 NLGN3 NLGN4X OXTR

Graphical network of the top 20 diseases related to Atypical Autism:



Diseases related to Atypical Autism

Symptoms & Phenotypes for Atypical Autism

GenomeRNAi Phenotypes related to Atypical Autism according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.28 ARHGAP24
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.28 ARHGAP24 ATG4C RAB11FIP5
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.28 RAB11FIP5
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.28 ATG4C
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.28 ATG4C
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.28 ATG4C RAB11FIP5

Drugs & Therapeutics for Atypical Autism

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Evaluation of Integrative Practices Units Infant and Child Care for Unit Children With Typical or Atypical Autism (AUTISM) Completed NCT02154828
2 Cognitive Behavioural Therapy (CBT) and Recreational Activity for Autism Spectrum Disorders (ASD) Completed NCT01655173
3 MR Scanning of Very Young Children With Severe Developmental Disorders Completed NCT00156221

Search NIH Clinical Center for Atypical Autism

Genetic Tests for Atypical Autism

Anatomical Context for Atypical Autism

MalaCards organs/tissues related to Atypical Autism:

38
Temporal Lobe

Publications for Atypical Autism

Articles related to Atypical Autism:

(show all 16)
# Title Authors Year
1
Atypical autism in a boy with double duplication of 22q11.2: implications of increasing dosage. ( 29263838 )
2017
2
Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. ( 28595786 )
2017
3
Arteriovenous Malformation in a Youth with Atypical Autism Symptoms. ( 28989994 )
2017
4
Effectiveness of clozapine for the treatment of psychosis and disruptive behaviour in a child with Atypical Autism: A case report and a brief review of the evidence. ( 28704788 )
2017
5
Assessment of serum trace elements and electrolytes in children with childhood and atypical autism. ( 27707611 )
2016
6
Diseases of the gastrointestinal tract in individuals diagnosed as children with atypical autism: a Danish register study based on hospital diagnoses. ( 22987890 )
2013
7
Autism Spectrum Conditions. FAQs on Autism, Asperger Syndrome and Atypical Autism answered by International Experts. ( 21919953 )
2011
8
Epilepsy and other central nervous system diseases in atypical autism: a case control study. ( 21207076 )
2011
9
Psychiatric disorders in adults diagnosed as children with atypical autism. A case control study. ( 17768593 )
2008
10
A girl with neurofibromatosis type 1, atypical autism and mosaic ring chromosome 17. ( 17163520 )
2007
11
Comparison of high-functioning atypical autism and childhood autism by Childhood Autism Rating Scale-Tokyo version. ( 15009830 )
2004
12
Association of tuberous sclerosis of temporal lobes with autism and atypical autism. ( 9033466 )
1997
13
A comparative study of Asperger syndrome with high-functioning atypical autism. ( 9141143 )
1997
14
Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. ( 9106540 )
1997
15
Brief report: atypical autism and tuberous sclerosis in a sibling pair. ( 7592253 )
1995
16
Use of sulpiride in a case of atypical autism. ( 3372456 )
1988

Variations for Atypical Autism

Expression for Atypical Autism

Search GEO for disease gene expression data for Atypical Autism.

Pathways for Atypical Autism

GO Terms for Atypical Autism

Cellular components related to Atypical Autism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 9.26 NLGN3 NLGN4X
2 spanning component of membrane GO:0089717 9.16 NLGN3 NLGN4X
3 asymmetric, glutamatergic, excitatory synapse GO:0098985 8.96 NLGN3 NLGN4X
4 symmetric, GABA-ergic, inhibitory synapse GO:0098983 8.62 NLGN3 NLGN4X

Biological processes related to Atypical Autism according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 learning GO:0007612 9.52 NLGN3 NLGN4X
2 positive regulation of synapse assembly GO:0051965 9.51 NLGN3 OXTR
3 synapse organization GO:0050808 9.49 NLGN3 NLGN4X
4 adult behavior GO:0030534 9.48 NLGN3 NLGN4X
5 synaptic vesicle endocytosis GO:0048488 9.46 NLGN3 NLGN4X
6 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.43 NLGN3 OXTR
7 neuron cell-cell adhesion GO:0007158 9.4 NLGN3 NLGN4X
8 vocalization behavior GO:0071625 9.37 NLGN3 NLGN4X
9 presynapse assembly GO:0099054 9.32 NLGN3 NLGN4X
10 negative regulation of excitatory postsynaptic potential GO:0090394 9.26 NLGN3 NLGN4X
11 presynaptic membrane assembly GO:0097105 9.16 NLGN3 NLGN4X
12 postsynaptic membrane assembly GO:0097104 8.96 NLGN3 NLGN4X
13 social behavior GO:0035176 8.8 NLGN3 NLGN4X OXTR

Molecular functions related to Atypical Autism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 9.26 NLGN3 NLGN4X
2 scaffold protein binding GO:0097110 9.16 NLGN3 NLGN4X
3 carboxylic ester hydrolase activity GO:0052689 8.96 NLGN3 NLGN4X
4 neurexin family protein binding GO:0042043 8.62 NLGN3 NLGN4X

Sources for Atypical Autism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
27 GO
28 GTR
29 HGMD
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 MedGen
41 MeSH
42 MESH via Orphanet
43 MGI
45 NCI
46 NCIt
47 NDF-RT
50 NINDS
51 Novoseek
53 OMIM
54 OMIM via Orphanet
58 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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