MCID: ATY003
MIFTS: 28

Atypical Autism

Categories: Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Atypical Autism

MalaCards integrated aliases for Atypical Autism:

Name: Atypical Autism 12 56 14 69
Pdd 12

Classifications:

Orphanet: 56  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:0060042
Orphanet 56 ORPHA199627
UMLS via Orphanet 70 C0338986
ICD10 via Orphanet 34 F84.1
ICD10 33 F84.1

Summaries for Atypical Autism

Disease Ontology : 12 An autism spectrum disorder that involves some autistic symptoms occuring after age 3 with an abscence of all the traits necessary for a diagnosis of autism.

MalaCards based summary : Atypical Autism, also known as pdd, is related to pervasive developmental disorder not otherwise specified and mental retardation, autosomal dominant 26. An important gene associated with Atypical Autism is PDP1 (Pyruvate Dehyrogenase Phosphatase Catalytic Subunit 1). The drugs Dopamine and Metformin have been mentioned in the context of this disorder. Affiliated tissues include brain and temporal lobe.

Related Diseases for Atypical Autism

Graphical network of the top 20 diseases related to Atypical Autism:



Diseases related to Atypical Autism

Symptoms & Phenotypes for Atypical Autism

Drugs & Therapeutics for Atypical Autism

Drugs for Atypical Autism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 16)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 2,Phase 3 51-61-6, 62-31-7 681
2
Metformin Approved Phase 4,Phase 3 657-24-9 14219 4091
3
Risperidone Approved, Investigational Phase 4,Phase 2,Phase 3 106266-06-2 5073
4
Aripiprazole Approved, Investigational Phase 4 129722-12-9 60795
5
Serotonin Phase 4,Phase 2,Phase 3 50-67-9 5202
6 Central Nervous System Depressants Phase 4,Phase 3,Phase 2
7 Serotonin Agents Phase 4,Phase 2,Phase 3
8 Serotonin Antagonists Phase 4,Phase 2,Phase 3
9 Neurotransmitter Agents Phase 4,Phase 2,Phase 3
10 Tranquilizing Agents Phase 4,Phase 3,Phase 2
11 Dopamine Agents Phase 4,Phase 2,Phase 3
12 Dopamine Antagonists Phase 4,Phase 2,Phase 3
13 Hypoglycemic Agents Phase 4,Phase 3
14 Pharmaceutical Solutions Phase 4,Phase 3
15 Psychotropic Drugs Phase 4,Phase 3,Phase 2
16 Antipsychotic Agents Phase 4,Phase 3,Phase 2

Interventional clinical trials:

(show all 14)

id Name Status NCT ID Phase Drugs
1 Biomarkers in Autism of Aripiprazole and Risperidone Treatment (BAART) Completed NCT01333072 Phase 4 Aripiprazole;Risperidone
2 A Study of the Effectiveness and Safety of Two Doses of Risperidone in the Treatment of Children and Adolescents With Autistic Disorder Completed NCT00576732 Phase 4 Placebo;Risperidone high dose;Risperidone low dose
3 A Study to Evaluate the Safety and the Effects of Risperidone Compared With Other Atypical Antipsychotic Drugs on the Growth and Sexual Maturation in Children Completed NCT01050582 Phase 4 Risperidone;Other atypical antipsychotic drugs
4 An Open-label Trial of Metformin for Weight Control of Pediatric Patients on Antipsychotic Medications. Completed NCT00391261 Phase 4 Metformin
5 Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD) Completed NCT01825798 Phase 3 Metformin;Placebo
6 Pharmacogenomics in Autism Treatment Completed NCT00584701 Phase 2, Phase 3 Risperidone
7 Clinical Evaluation of Integrative Practices Units Infant and Child Care for Unit Children With Typical or Atypical Autism (AUTISM) Completed NCT02154828
8 Cognitive Behavioural Therapy (CBT) and Recreational Activity for Autism Spectrum Disorders (ASD) Completed NCT01655173
9 MR Scanning of Very Young Children With Severe Developmental Disorders Completed NCT00156221
10 Gaze Modification Strategies for Toddlers With Autism Spectrum Disorder Completed NCT02488226
11 Multisensorial Information's Treatment in Autism Spectrum Disorder Completed NCT02579109
12 Brain Mechanisms for Language Processing in Adolescents With Autism Spectrum Disorder Recruiting NCT02700074
13 Design Of WELL Being Monitoring Systems, Application in Autism Recruiting NCT02275455
14 Neurophysiological Study of Sensory and Cognitive Processes in Healthy Children and Adults Recruiting NCT03182400

Search NIH Clinical Center for Atypical Autism

Genetic Tests for Atypical Autism

Anatomical Context for Atypical Autism

MalaCards organs/tissues related to Atypical Autism:

39
Brain, Temporal Lobe

Publications for Atypical Autism

Articles related to Atypical Autism:

(show all 14)
id Title Authors Year
1
Effectiveness of clozapine for the treatment of psychosis and disruptive behaviour in a child with Atypical Autism: A case report and a brief review of the evidence. ( 28704788 )
2017
2
Increased risk for an atypical autism diagnosis following Thimerosal-containing vaccine exposure in the United States: A prospective longitudinal case-control study in the Vaccine Safety Datalink. ( 28595786 )
2017
3
Assessment of serum trace elements and electrolytes in children with childhood and atypical autism. ( 27707611 )
2016
4
Diseases of the gastrointestinal tract in individuals diagnosed as children with atypical autism: a Danish register study based on hospital diagnoses. ( 22987890 )
2013
5
Autism Spectrum Conditions. FAQs on Autism, Asperger Syndrome and Atypical Autism answered by International Experts. ( 21919953 )
2011
6
Epilepsy and other central nervous system diseases in atypical autism: a case control study. ( 21207076 )
2011
7
Psychiatric disorders in adults diagnosed as children with atypical autism. A case control study. ( 17768593 )
2008
8
A girl with neurofibromatosis type 1, atypical autism and mosaic ring chromosome 17. ( 17163520 )
2007
9
Comparison of high-functioning atypical autism and childhood autism by Childhood Autism Rating Scale-Tokyo version. ( 15009830 )
2004
10
Association of tuberous sclerosis of temporal lobes with autism and atypical autism. ( 9033466 )
1997
11
A comparative study of Asperger syndrome with high-functioning atypical autism. ( 9141143 )
1997
12
Autism or atypical autism in maternally but not paternally derived proximal 15q duplication. ( 9106540 )
1997
13
Brief report: atypical autism and tuberous sclerosis in a sibling pair. ( 7592253 )
1995
14
Use of sulpiride in a case of atypical autism. ( 3372456 )
1988

Variations for Atypical Autism

Expression for Atypical Autism

Search GEO for disease gene expression data for Atypical Autism.

Pathways for Atypical Autism

GO Terms for Atypical Autism

Cellular components related to Atypical Autism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 excitatory synapse GO:0060076 8.62 NLGN3 NLGN4X

Biological processes related to Atypical Autism according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of synapse assembly GO:0051965 9.49 NLGN3 OXTR
2 learning GO:0007612 9.48 NLGN3 NLGN4X
3 synapse organization GO:0050808 9.46 NLGN3 NLGN4X
4 adult behavior GO:0030534 9.43 NLGN3 NLGN4X
5 positive regulation of synaptic transmission, glutamatergic GO:0051968 9.4 NLGN3 OXTR
6 neuron cell-cell adhesion GO:0007158 9.37 NLGN3 NLGN4X
7 vocalization behavior GO:0071625 9.32 NLGN3 NLGN4X
8 negative regulation of excitatory postsynaptic potential GO:0090394 9.26 NLGN3 NLGN4X
9 presynaptic membrane assembly GO:0097105 9.16 NLGN3 NLGN4X
10 social behavior GO:0035176 8.8 NLGN3 NLGN4X OXTR
11 postsynaptic membrane assembly GO:0097104 8.65 NLGN3

Molecular functions related to Atypical Autism according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 cell adhesion molecule binding GO:0050839 9.26 NLGN3 NLGN4X
2 scaffold protein binding GO:0097110 9.16 NLGN3 NLGN4X
3 carboxylic ester hydrolase activity GO:0052689 8.96 NLGN3 NLGN4X
4 neurexin family protein binding GO:0042043 8.62 NLGN3 NLGN4X

Sources for Atypical Autism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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