MCID: ATY005
MIFTS: 52

Atypical Teratoid Rhabdoid Tumor malady

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Atypical Teratoid Rhabdoid Tumor

Aliases & Descriptions for Atypical Teratoid Rhabdoid Tumor:

Name: Atypical Teratoid Rhabdoid Tumor 12 14
Rhabdoid Tumor Predisposition Syndrome 12 69
Atypical Teratoid/rhabdoid Tumor 12 69
Rhabdoid Tumor of the Cns 12
at/rt 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2129
NCIt 47 C6906
SNOMED-CT 64 128792003
UMLS 69 C1266184

Summaries for Atypical Teratoid Rhabdoid Tumor

Disease Ontology : 12 A brain cancer that is usually located in the brain, but can occur anywhere in the central nervous system.

MalaCards based summary : Atypical Teratoid Rhabdoid Tumor, also known as rhabdoid tumor predisposition syndrome, is related to pleomorphic xanthoastrocytoma and childhood medulloblastoma, and has symptoms including ataxia, seizures and reduced consciousness/confusion. An important gene associated with Atypical Teratoid Rhabdoid Tumor is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are ERK Signaling and Focal Adhesion. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and cerebellum, and related phenotypes are Increased shRNA abundance (Z-score > 2) and cellular

Wikipedia : 71 Atypical teratoid rhabdoid tumor (AT/RT) is a rare tumor usually diagnosed in childhood. Although... more...

Related Diseases for Atypical Teratoid Rhabdoid Tumor

Diseases related to Atypical Teratoid Rhabdoid Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
id Related Disease Score Top Affiliating Genes
1 pleomorphic xanthoastrocytoma 30.4 GFAP SYP
2 childhood medulloblastoma 30.1 GFAP SMARCB1 SYP
3 rhabdoid cancer 12.0
4 rhabdoid tumors, somatic 11.4
5 rhabdoid tumor predisposition syndrome 2 11.2
6 medulloblastoma 10.4
7 diabetes hypogonadism deafness mental retardation 10.3 GFAP SYP
8 ectopic aldosterone-producing tumor 10.3 SMARCA4 SMARCB1
9 papillary tumor of the pineal region 10.3 GFAP SYP
10 brain stem ependymoma 10.3 GFAP SYP
11 thrombophlebitis 10.3 GFAP SMARCB1
12 intrahepatic bile duct adenoma 10.3 GFAP SYP
13 pilocytic astrocytoma of cerebellum 10.3 GFAP SYP
14 children's interstitial lung disease 10.3 GFAP SYP
15 trombiculiasis 10.3 GFAP SMARCB1
16 cervical benign neoplasm 10.3 GFAP SYP
17 epidermal appendage tumor 10.3 GFAP SYP
18 microinvasive cervical squamous cell carcinoma 10.3 GFAP SYP
19 clear cell meningioma 10.3 GFAP SYP
20 nephrogenic adenoma of urinary bladder 10.3 GFAP SYP
21 paternal uniparental disomy of chromosome 1 10.3 GFAP SYP
22 cerebral folate receptor alpha deficiency 10.3 GFAP SYP
23 vulvar benign neoplasm 10.3 GFAP SYP
24 corneal intraepithelial neoplasm 10.3 SMARCA4 SYP
25 adenofibroma 10.3 GFAP SYP
26 pilocytic astrocytoma 10.2 GFAP SYP
27 ovarian large-cell neuroendocrine carcinoma 10.2 SMARCB1 SYP
28 behcet's syndrome arthropathy 10.2 GFAP SYP
29 aneurysm of sinus of valsalva 10.2 GFAP SYP
30 proliferative glomerulonephritis 10.2 CTNNB1 SYP
31 male reproductive system disease 10.2 GFAP SYP
32 mediastinal granular cell myoblastoma 10.2 GFAP SYP
33 cerebritis 10.2
34 ganglioglioma 10.2
35 central neurocytoma 10.2 GFAP SYP
36 myxopapillary ependymoma 10.2 GFAP SMARCB1 SYP
37 mast-cell sarcoma 10.2 GFAP SMARCB1 SYP
38 olfactory neuroblastoma 10.2 GFAP SMARCB1 SYP
39 pineoblastoma 10.2 GFAP SMARCB1 SYP
40 brain stem astrocytic neoplasm 10.2 GFAP SMARCB1 SYP
41 dysgerminoma of ovary 10.2 GFAP SMARCB1 SYP
42 melanotic neurilemmoma 10.2 GFAP SMARCB1 SYP
43 clear cell variant infiltrating bladder urothelial carcinoma 10.2 GFAP SMARCB1 SYP
44 hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 10.2 GFAP SYP
45 inner ear cancer 10.2 GFAP SMARCB1 SYP
46 pharynx cancer 10.2 GFAP SMARCB1 SYP
47 superior vena cava syndrome 10.2 GFAP SYP
48 cervicitis 10.1
49 sarcoma 10.1
50 choroiditis 10.1

Graphical network of the top 20 diseases related to Atypical Teratoid Rhabdoid Tumor:



Diseases related to Atypical Teratoid Rhabdoid Tumor

Symptoms & Phenotypes for Atypical Teratoid Rhabdoid Tumor

Human phenotypes related to Atypical Teratoid Rhabdoid Tumor:

32 (show all 16)
id Description HPO Frequency HPO Source Accession
1 ataxia 32 HP:0001251
2 seizures 32 HP:0001250
3 reduced consciousness/confusion 32 HP:0004372
4 nausea and vomiting 32 HP:0002017
5 muscle weakness 32 HP:0001324
6 macrocephaly 32 HP:0000256
7 hydrocephalus 32 HP:0000238
8 cerebral calcification 32 HP:0002514
9 cranial nerve paralysis 32 HP:0006824
10 irritability 32 HP:0000737
11 hemiplegia/hemiparesis 32 HP:0004374
12 limitation of joint mobility 32 HP:0001376
13 migraine 32 HP:0002076
14 cerebral palsy 32 HP:0100021
15 apathy 32 HP:0000741
16 malignant neoplasm of the central nervous system 32 HP:0100836

GenomeRNAi Phenotypes related to Atypical Teratoid Rhabdoid Tumor according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.88 SMARCA4
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.88 CTNNB1 SMARCA4
3 Increased shRNA abundance (Z-score > 2) GR00366-A-113 9.88 CTNNB1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.88 IGF1R
5 Increased shRNA abundance (Z-score > 2) GR00366-A-126 9.88 CCND1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.88 IGF1R
7 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.88 CCND1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.88 CCND1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.88 CCND1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-169 9.88 IGF1R
11 Increased shRNA abundance (Z-score > 2) GR00366-A-172 9.88 SMARCA4
12 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.88 IGF1R SMARCA4 CCND1 CTNNB1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-197 9.88 CTNNB1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-199 9.88 IGF1R CCND1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.88 CCND1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.88 CCND1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.88 IGF1R
18 Increased shRNA abundance (Z-score > 2) GR00366-A-25 9.88 CCND1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-36 9.88 CCND1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.88 IGF1R
21 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.88 CTNNB1 IGF1R
22 Increased shRNA abundance (Z-score > 2) GR00366-A-49 9.88 CTNNB1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-67 9.88 CTNNB1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-73 9.88 CTNNB1
25 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.88 CTNNB1 IGF1R
26 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.88 CTNNB1
27 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.88 IGF1R SMARCA4
28 Increased shRNA abundance (Z-score > 2) GR00366-A-93 9.88 SMARCA4
29 Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435) GR00104-A-0 9.13 AURKA CCND1 IGF2

MGI Mouse Phenotypes related to Atypical Teratoid Rhabdoid Tumor:

44 (show all 17)
id Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.2 AURKA CCND1 CTNNB1 GFAP IGF1R IGF2
2 behavior/neurological MP:0005386 10.17 CCND1 CTNNB1 GFAP IGF1R IGF2 SMARCB1
3 cardiovascular system MP:0005385 10.16 IGF1R IGF2 SMARCA4 SMARCB1 SPP1 CCND1
4 growth/size/body region MP:0005378 10.15 AURKA CCND1 CTNNB1 GFAP IGF1R IGF2
5 hematopoietic system MP:0005397 10.08 AURKA CCND1 CTNNB1 IGF1R IGF2 SMARCA4
6 digestive/alimentary MP:0005381 10.07 CCND1 CTNNB1 GFAP IGF1R IGF2 SMARCA4
7 immune system MP:0005387 10.06 CCND1 CTNNB1 GFAP IGF1R IGF2 SMARCA4
8 mortality/aging MP:0010768 10.02 CCND1 CTNNB1 GFAP IGF1R IGF2 SMARCA4
9 craniofacial MP:0005382 10.01 CCND1 CTNNB1 IGF1R IGF2 SMARCA4 SPP1
10 embryo MP:0005380 9.99 AURKA CTNNB1 IGF1R IGF2 SMARCA4 SMARCB1
11 integument MP:0010771 9.91 CCND1 CTNNB1 IGF1R IGF2 SMARCA4 SPP1
12 liver/biliary system MP:0005370 9.88 CTNNB1 IGF1R IGF2 SMARCA4 SMARCB1 SPP1
13 muscle MP:0005369 9.87 CTNNB1 GFAP IGF1R IGF2 SMARCA4 SMARCB1
14 nervous system MP:0003631 9.81 CCND1 CTNNB1 GFAP IGF1R IGF2 SMARCA4
15 neoplasm MP:0002006 9.8 AURKA CCND1 CTNNB1 IGF1R SMARCA4 SMARCB1
16 respiratory system MP:0005388 9.43 IGF1R IGF2 SMARCA4 SPP1 CCND1 CTNNB1
17 vision/eye MP:0005391 9.1 SMARCB1 CCND1 CTNNB1 GFAP IGF2 SMARCA4

Drugs & Therapeutics for Atypical Teratoid Rhabdoid Tumor

Drugs for Atypical Teratoid Rhabdoid Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 153)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 2, Phase 3, Phase 1 41575-94-4 10339178 498142 38904
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3, Phase 1 50-18-0, 6055-19-2 2907
3
Etoposide Approved Phase 2, Phase 3, Phase 1, Early Phase 1 33419-42-0 36462
4
Melphalan Approved Phase 2, Phase 3,Phase 1 148-82-3 4053 460612
5
Thiotepa Approved Phase 2, Phase 3, Phase 1 52-24-4 5453
6
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
7
Lenograstim Approved Phase 3,Phase 2,Phase 1 135968-09-1
8
Methotrexate Approved Phase 3,Phase 2,Phase 1,Early Phase 1 1959-05-2, 59-05-2 126941
9
Temozolomide Approved, Investigational Phase 3,Phase 2,Phase 1 85622-93-1 5394
10
Vincristine Approved, Investigational Phase 3,Phase 2,Phase 1 2068-78-2, 57-22-7 5978
11
Dactinomycin Approved Phase 3,Phase 2 50-76-0 2019 457193
12
Doxorubicin Approved, Investigational Phase 3,Phase 2 23214-92-8 31703
13
Sulfamethoxazole Approved Phase 3 723-46-6 5329
14
Trimethoprim Approved, Vet_approved Phase 3 738-70-5 5578
15
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
16
Levoleucovorin Approved Phase 3,Phase 2,Early Phase 1 68538-85-2
17
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1,Early Phase 1 59-30-3 6037
18
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 54575, 6560146 143
19
Doxil Approved June 1999 Phase 3,Phase 2 31703
20 Etoposide phosphate Phase 2, Phase 3, Phase 1, Early Phase 1
21 Alkylating Agents Phase 3,Phase 2,Phase 1
22 Antimetabolites Phase 3,Phase 2,Phase 1,Early Phase 1
23 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Early Phase 1
24 Antimitotic Agents Phase 3,Phase 2,Phase 1
25 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
26 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Early Phase 1
27 Antirheumatic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
28 Dermatologic Agents Phase 3,Phase 2,Phase 1,Early Phase 1
29 Folic Acid Antagonists Phase 3,Phase 2,Phase 1,Early Phase 1
30 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
31 Nucleic Acid Synthesis Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
32 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Early Phase 1
33 Vitamin B Complex Phase 3,Phase 2,Phase 1,Early Phase 1
34 Adjuvants, Immunologic Phase 3,Phase 2,Phase 1
35 Liver Extracts Phase 3,Phase 1,Phase 2
36 Protective Agents Phase 3,Phase 2,Phase 1
37 Anti-Bacterial Agents Phase 3,Phase 2,Phase 1
38 Antibiotics, Antitubercular Phase 3,Phase 2,Phase 1
39 Anti-Infective Agents Phase 3,Phase 2,Phase 1
40 Adjuvants, Anesthesia Phase 3
41 Analgesics Phase 3
42 Analgesics, Opioid Phase 3
43 Anesthetics Phase 3
44 Anesthetics, General Phase 3
45 Anesthetics, Intravenous Phase 3
46 Central Nervous System Depressants Phase 3
47 Narcotics Phase 3
48 pancreatic polypeptide Phase 3
49 Peripheral Nervous System Agents Phase 3,Phase 1
50 Antidotes Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 75)
id Name Status NCT ID Phase
1 Stem Cell Transplant for High Risk Central Nervous System (CNS) Tumors Unknown status NCT00179803 Phase 2, Phase 3
2 Combination Chemotherapy With or Without Etoposide Followed By an Autologous Stem Cell Transplant in Treating Young Patients With Previously Untreated Malignant Brain Tumors Unknown status NCT00392886 Phase 3
3 Chemotherapy With or Without Surgery, Radiation Therapy, or Stem Cell Transplantation in Treating Young Patients With Kidney Tumors Completed NCT00002610 Phase 3
4 Combination Chemotherapy Followed by Second-Look Surgery and Radiation Therapy in Treating Children With Nonmetastatic Medulloblastoma or Primitive Neuroectodermal Tumor Completed NCT00006461 Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3
6 Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer Completed NCT00002611 Phase 3
7 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Active, not recruiting NCT00085202 Phase 3
8 Combination Chemotherapy, Radiation Therapy, and an Autologous Peripheral Blood Stem Cell Transplant in Treating Young Patients With Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System Active, not recruiting NCT00653068 Phase 3
9 Oxaliplatin in Treating Children With Recurrent or Refractory Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed NCT00047177 Phase 2
10 Chemotherapy Combined With Radiation Therapy for Newly Diagnosed CNS AT/RT Completed NCT00084838 Phase 2
11 Combination Chemotherapy, Radiation Therapy, and/or Surgery in Treating Patients With High-Risk Kidney Tumors Completed NCT00335556 Phase 2
12 Chemotherapy in Treating Patients With Solid Tumors Completed NCT00003103 Phase 1, Phase 2
13 Phase 2 Study of Alisertib Therapy for Rhabdoid Tumors Recruiting NCT02114229 Phase 2
14 A Phase II, Multicenter Study of the EZH2 Inhibitor Tazemetostat in Adult Subjects With INI1-Negative Tumors or Relapsed/Refractory Synovial Sarcoma Recruiting NCT02601950 Phase 2
15 Tazemetostat Rollover Study (TRuST): An Open-Label Rollover Study Recruiting NCT02875548 Phase 2
16 Phase II Study of Intraventricular Methotrexate in Children With Recurrent or Progressive Malignant Brain Tumors Recruiting NCT02684071 Phase 2
17 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Recruiting NCT00983398 Phase 1, Phase 2
18 A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Preliminary Efficacy of Atezolizumab (Anti-Programmed Death-Ligand 1 [PD-L1] Antibody) in Pediatric and Young Adult Participants With Solid Tumors Recruiting NCT02541604 Phase 1, Phase 2
19 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2
20 Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma Active, not recruiting NCT00602667 Phase 2
21 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2
22 Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer Active, not recruiting NCT00445965 Phase 2
23 Phase II Pediatric Study With Dabrafenib in HGG Patients Not yet recruiting NCT02684058 Phase 2
24 Antineoplaston Therapy in Treating Children With Rhabdoid Tumor of the Central Nervous System Terminated NCT00003469 Phase 2
25 Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors Unknown status NCT00007813 Phase 1
26 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1
27 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1
28 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1
29 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1
30 Vorinostat With or Without Isotretinoin in Treating Young Patients With Recurrent or Refractory Solid Tumors, Lymphoma, or Leukemia Completed NCT00217412 Phase 1
31 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1
32 SCH 66336 in Treating Children With Recurrent or Progressive Brain Tumors Completed NCT00015899 Phase 1
33 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1
34 Temozolomide, Vincristine, and Irinotecan in Treating Young Patients With Refractory Solid Tumors Completed NCT00138216 Phase 1
35 Chemotherapy and Stem Cell Transplantation in Treating Children With Central Nervous System Cancer Completed NCT00053118 Phase 1
36 Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors Completed NCT00303940 Phase 1
37 p28 in Treating Younger Patients With Recurrent or Progressive Central Nervous System Tumors Completed NCT01975116 Phase 1
38 Modified Measles Virus (MV-NIS) for Children and Young Adults With Recurrent Medulloblastoma or Recurrent ATRT Recruiting NCT02962167 Phase 1
39 A Phase 1 Study of the EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Sarcoma Recruiting NCT02601937 Phase 1
40 Methotrexate Infusion Into Fourth Ventricle in Children With Recurrent Malignant Fourth Ventricular Brain Tumors Recruiting NCT02458339 Phase 1
41 Simvastatin With Topotecan and Cyclophosphamide in Relapsed and/or Refractory Pediatric Solid and CNS Tumors Recruiting NCT02390843 Phase 1
42 A Study of CD45RA+ Depleted Haploidentical Stem Cell Transplantation in Children With Relapsed or Refractory Solid Tumors and Lymphomas Recruiting NCT01625351 Phase 1
43 Wild-Type Reovirus in Combination With Sargramostim in Treating Younger Patients With High-Grade Relapsed or Refractory Brain Tumors Recruiting NCT02444546 Phase 1
44 Abemaciclib in Children With DIPG or Recurrent/Refractory Solid Tumors Recruiting NCT02644460 Phase 1
45 HSV G207 Alone or With a Single Radiation Dose in Children With Progressive or Recurrent Supratentorial Brain Tumors Recruiting NCT02457845 Phase 1
46 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Refractory, Recurrent, or Advanced CNS or Leptomeningeal Cancer Recruiting NCT00089245 Phase 1
47 Study of Safety and Efficacy in Patients With Malignant Rhabdoid Tumors (MRT) and Neuroblastoma Active, not recruiting NCT01747876 Phase 1
48 Aflac ST0901 CHOANOME - Sirolimus in Solid Tumors Active, not recruiting NCT01331135 Phase 1
49 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1
50 MT2004-30: Tomotherapy for Solid Tumors Terminated NCT00623077 Phase 1

Search NIH Clinical Center for Atypical Teratoid Rhabdoid Tumor

Genetic Tests for Atypical Teratoid Rhabdoid Tumor

Anatomical Context for Atypical Teratoid Rhabdoid Tumor

MalaCards organs/tissues related to Atypical Teratoid Rhabdoid Tumor:

39
Brain, Pineal, Cerebellum, Spinal Cord, Pituitary, Lung, Ovary

Publications for Atypical Teratoid Rhabdoid Tumor

Articles related to Atypical Teratoid Rhabdoid Tumor:

(show top 50) (show all 222)
id Title Authors Year
1
Description of a new oncogenic mechanism for atypical teratoid rhabdoid tumors in patients with ring chromosome 22. ( 27734605 )
2017
2
Ewing Sarcoma and Atypical Teratoid Rhabdoid Tumor. ( 28382842 )
2017
3
Atypical teratoid/rhabdoid tumor arising from the trigeminal nerve in an adult. ( 27335108 )
2016
4
Tandem High-Dose Chemotherapy and Autologous Stem Cell Transplantation for Atypical Teratoid/Rhabdoid Tumor. ( 27034140 )
2016
5
Long-term survival of an infant with an atypical teratoid/rhabdoid tumor following subtotal resection and low-cumulative dose chemotherapy: a case report. ( 26747622 )
2016
6
Primary atypical teratoid/rhabdoid tumor of the spine in an adult patient. ( 27069744 )
2016
7
Multifocal atypical teratoid/rhabdoid tumor: a rare entity. ( 27757569 )
2016
8
Atypical teratoid/rhabdoid tumor in the sella turcica of an elderly female with a distinct vascular pattern and genetic alterations. ( 27595781 )
2016
9
Overexpression of TEAD4 in atypical teratoid/rhabdoid tumor: New insight to the pathophysiology of an aggressive brain tumor. ( 27966820 )
2016
10
Pituitary apoplexy as presentation of atypical teratoid/rhabdoid tumor in an adult. ( 27349334 )
2016
11
Ewing Sarcoma and Atypical Teratoid Rhabdoid Tumor: A FISH and Immunohistochemical Comparison. ( 27467095 )
2016
12
Adult-onset atypical teratoid/rhabdoid tumor featuring long spindle cells with nuclear palisading and perivascular pseudorosettes. ( 27297614 )
2016
13
Atypical Teratoid/Rhabdoid Tumor (AT/RT) Arising From Ependymoma: A Type of AT/RT Secondarily Developing From Other Primary Central Nervous System Tumors. ( 26769252 )
2016
14
Multimodal therapy in children and adolescents with newly diagnosed atypical teratoid rhabdoid tumor: individual pooled data analysis and review of the literature. ( 26608522 )
2016
15
Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor. ( 26646792 )
2016
16
Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth. ( 27370397 )
2016
17
Atypical Teratoid/Rhabdoid Tumor of the Pineal Region in a Young Adult Male Patient: Case Report and Review of the Literature. ( 27144539 )
2016
18
LIN28B is highly expressed in atypical teratoid/rhabdoid tumor (AT/RT) and suppressed through the restoration of SMARCB1. ( 27095948 )
2016
19
Two-stage surgical resection of an atypical teratoid rhabdoid tumor occupying the infratentorial and supratentorial compartment in children under two years: Report of two cases. ( 26812670 )
2016
20
Atypical Teratoid Rhabdoid Tumor Diagnosis after Partial Resection of Dysembryoplastic Neuroepithelial Tumor: Case Report and Review of the Literature. ( 26978682 )
2016
21
Atypical teratoid/rhabdoid tumor arising in a malignant glioma. ( 27472468 )
2016
22
A case of primary spinal atypical teratoid/rhabdoid tumor in a 5-year-old child. ( 27606020 )
2016
23
Atypical teratoid/rhabdoid tumor (AT/RT) arising from the acoustic nerve in a young adult: a case report and a review of literature. ( 25634176 )
2015
24
Lumbar spinal atypical teratoid rhabdoid tumor. ( 26234633 )
2015
25
Atypical teratoid rhabdoid tumor: long-term survival after chemoradiotherapy. ( 25939716 )
2015
26
Atypical teratoid/rhabdoid tumor of the brain in an adult with 22q deletion but no absence of INI1 protein: a case report and review of the literature. ( 25909878 )
2015
27
Cisplatin-selected resistance is associated with increased motility and stem-like properties via activation of STAT3/Snail axis in atypical teratoid/rhabdoid tumor cells. ( 25638155 )
2015
28
Atypical teratoid rhabdoid tumor involving the nasal cavities and anterior skull base. ( 26567940 )
2015
29
Wnt pathway in atypical teratoid rhabdoid tumors. ( 25246426 )
2015
30
Atypical teratoid/rhabdoid tumor with hereditary multiple exostoses in an 18-year-old male: A case report. ( 26622709 )
2015
31
A case of atypical teratoid/rhabdoid tumor in the internal auditory canal. ( 25450856 )
2015
32
Atypical Teratoid Rhabdoid Tumor in a Teenager with Unusual Infiltration Into the Jugular Foramen. ( 26187115 )
2015
33
SMARCA4-Mutated Atypical Teratoid/Rhabdoid Tumor with Retained BRG1 Expression. ( 26469284 )
2015
34
Primary atypical teratoid/rhabdoid tumor of the optic nerve: a rare entity in an exceptional location. ( 25934090 )
2015
35
Atypical teratoid/ rhabdoid tumor, an immunohistochemical study of potential diagnostic and prognostic markers. ( 26207291 )
2015
36
A case of relapsing spinal atypical teratoid/rhabdoid tumor (AT/RT) responding to vinorelbine, cyclophosphamide, and celecoxib. ( 26008576 )
2015
37
Atypical teratoid/rhabdoid tumor (ATRT) arising from the 3rd cranial nerve in infants: a clinical-radiological entity? ( 26148473 )
2015
38
Adenovirus necrotizing hepatitis complicating atypical teratoid rhabdoid tumor. ( 26508178 )
2015
39
Generation of a Mouse Model of Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System through Combined Deletion of Snf5 and p53. ( 26363008 )
2015
40
Investigation of the location of atypical teratoid/rhabdoid tumor. ( 25953096 )
2015
41
Atypical teratoid rhabdoid tumor of the lateral ventricle. ( 26962351 )
2015
42
Exome Sequencing of an Adult Pituitary Atypical Teratoid Rhabdoid Tumor. ( 26557502 )
2015
43
Intracranial atypical teratoid rhabdoid tumor: current management and a single institute experience of 15 patients from north India. ( 25646852 )
2015
44
Relapse and metastasis of atypical teratoid/rhabdoid tumor in a boy with neurofibromatosis type 1 treated with recombinant human growth hormone. ( 25625887 )
2015
45
Disrupting LIN28 in atypical teratoid rhabdoid tumors reveals the importance of the mitogen activated protein kinase pathway as a therapeutic target. ( 25638158 )
2015
46
Primary atypical teratoid/rhabdoid tumor of central nervous system in children: a clinicopathological analysis and review of literature in China. ( 24966951 )
2014
47
Synchronous congenital malignant rhabdoid tumor of the orbit and atypical teratoid/rhabdoid tumor-feasibility and efficacy of multimodal therapy in a long-term survivor. ( 25262118 )
2014
48
Atypical teratoid/rhabdoid tumor arising in pleomorphic xanthoastrocytoma: a case report. ( 25268025 )
2014
49
Intracranial atypical teratoid/rhabdoid tumor presenting as an axillary mass: a case report and review of literature. ( 24555876 )
2014
50
Atypical teratoid rhabdoid tumor in adulthood. ( 24569171 )
2014

Variations for Atypical Teratoid Rhabdoid Tumor

Expression for Atypical Teratoid Rhabdoid Tumor

Search GEO for disease gene expression data for Atypical Teratoid Rhabdoid Tumor.

Pathways for Atypical Teratoid Rhabdoid Tumor

Pathways related to Atypical Teratoid Rhabdoid Tumor according to GeneCards Suite gene sharing:

(show all 14)
id Super pathways Score Top Affiliating Genes
1
Show member pathways
13.52 AURKA CCND1 CTNNB1 GFAP IGF1R IGF2
2
Show member pathways
12.6 CCND1 CTNNB1 IGF1R SPP1
3
Show member pathways
11.77 CCND1 CTNNB1 IGF1R
4 11.76 CCND1 CTNNB1 IGF1R IGF2
5 11.48 GFAP SMARCA4 SYP
6 11.44 CCND1 CTNNB1 SMARCA4
7 11.44 AURKA CCND1 CTNNB1 SMARCA4
8
Show member pathways
11.34 CCND1 SMARCA4 SMARCB1
9 11.25 IGF1R IGF2 SPP1
10 11.04 CCND1 CTNNB1
11 10.97 CCND1 CTNNB1 IGF1R IGF2
12 10.96 CCND1 CTNNB1
13
Show member pathways
10.89 IGF1R IGF2
14 10.84 CCND1 CTNNB1

GO Terms for Atypical Teratoid Rhabdoid Tumor

Cellular components related to Atypical Teratoid Rhabdoid Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA4 SMARCB1
2 nBAF complex GO:0071565 8.96 SMARCA4 SMARCB1
3 npBAF complex GO:0071564 8.62 SMARCA4 SMARCB1

Biological processes related to Atypical Teratoid Rhabdoid Tumor according to GeneCards Suite gene sharing:

(show all 11)
id Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.55 CCND1 CTNNB1 HMGA2 IGF1R IGF2
2 liver regeneration GO:0097421 9.49 AURKA CCND1
3 positive regulation of mitotic nuclear division GO:0045840 9.48 AURKA IGF2
4 ATP-dependent chromatin remodeling GO:0043044 9.46 SMARCA4 SMARCB1
5 anterior/posterior axis specification GO:0009948 9.43 AURKA CTNNB1
6 nucleosome disassembly GO:0006337 9.4 SMARCA4 SMARCB1
7 epithelial tube branching involved in lung morphogenesis GO:0060441 9.37 CTNNB1 HMGA2
8 positive regulation by host of viral transcription GO:0043923 9.32 SMARCA4 SMARCB1
9 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter GO:1901838 9.26 SMARCA4 SMARCB1
10 positive regulation of glucose mediated signaling pathway GO:1902661 8.96 SMARCA4 SMARCB1
11 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 8.92 CTNNB1 HMGA2 SMARCA4 SMARCB1

Molecular functions related to Atypical Teratoid Rhabdoid Tumor according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.46 CCND1 CTNNB1 HMGA2 SMARCA4
2 insulin receptor binding GO:0005158 9.32 IGF1R IGF2
3 Tat protein binding GO:0030957 9.26 SMARCA4 SMARCB1
4 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 8.96 SMARCA4 SMARCB1
5 nucleosomal DNA binding GO:0031492 8.8 HMGA2 SMARCA4 SMARCB1

Sources for Atypical Teratoid Rhabdoid Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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