MCID: ATY016
MIFTS: 21

Atypical Werner Syndrome malady

Fetal diseases category

Summaries for Atypical Werner Syndrome

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32MalaCards
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MalaCards: Atypical Werner Syndrome, also known as atypical progeroid syndrome, is related to werner syndrome and mandibuloacral dysplasia. An important gene associated with Atypical Werner Syndrome is LMNA (lamin A/C), and among its related pathways are Adipogenesis and DNA Damage. The compounds rosiglitazone and arginine have been mentioned in the context of this disorder. Related mouse phenotypes are adipose tissue and digestive/alimentary.

Aliases & Classifications for Atypical Werner Syndrome

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42NIH Rare Diseases, 20GeneTests, 48Orphanet, 26ICD10 via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Fetal diseases


Aliases & Descriptions:

atypical werner syndrome 42 20 48
atypical progeroid syndrome 42 48


External Ids:

ICD10 via Orphanet26 E34.8

Related Diseases for Atypical Werner Syndrome

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Atypical Werner Syndrome:



Diseases related to atypical werner syndrome

Clinical Features for Atypical Werner Syndrome

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Drugs & Therapeutics for Atypical Werner Syndrome

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Atypical Werner Syndrome

Drug clinical trials:

Search ClinicalTrials for Atypical Werner Syndrome

Search NIH Clinical Center for Atypical Werner Syndrome

Search CenterWatch for Atypical Werner Syndrome

Genetic Tests for Atypical Werner Syndrome

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20GeneTests
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Genetic tests related to Atypical Werner Syndrome:

id Genetic test Affiliating Genes
1 Atypical Werner Syndrome20 LMNA

Anatomical Context for Atypical Werner Syndrome

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Animal Models for Atypical Werner Syndrome or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Atypical Werner Syndrome:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053758.7LMNA, INS, WRN
2MP:00053818.7LMNA, INS, WRN
3MP:00053918.6WRN, INS, LMNA
4MP:00053798.6LMNA, INS, WRN
5MP:00053908.5WRN, INS, LMNA
6MP:00053858.5LMNA, INS, WRN
7MP:00107718.4LMNA, INS, WRN
8MP:00053898.2WRN, INS, LMNA

Publications for Atypical Werner Syndrome

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Genetic Variations for Atypical Werner Syndrome

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Expression for genes affiliated with Atypical Werner Syndrome

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Atypical Werner Syndrome

Search GEO for disease gene expression data for Atypical Werner Syndrome.

Pathways for genes affiliated with Atypical Werner Syndrome

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Sources:
37NCBI BioSystems Database, 4Cell Signaling Technology
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Pathways related to Atypical Werner Syndrome according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.3LMNA, INS
2
Hide members
9.0LMNA, WRN

Compounds for genes affiliated with Atypical Werner Syndrome

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Sources:
44Novoseek, 49PharmGKB, 28IUPHAR, 11DrugBank, 24HMDB
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Compounds related to Atypical Werner Syndrome according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1rosiglitazone44 49 28 11 2413.3LMNA, INS
2arginine448.2LMNA, INS, WRN

GO Terms for genes affiliated with Atypical Werner Syndrome

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16Gene Ontology
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Biological processes related to Atypical Werner Syndrome according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of apoptotic processGO:0429819.0LMNA, WRN

Products for genes affiliated with Atypical Werner Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Atypical Werner Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet