MCID: ADT004
MIFTS: 24

Auditory Neuropathy malady

Neuronal diseases category

Summaries for Auditory Neuropathy

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Sources:
63Wikipedia, 32MalaCards
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Wikipedia:63 Auditory neuropathy (AN) is a variety of hearing loss in which the outer hair cells within the cochlea... more...

MalaCards: Auditory Neuropathy, also known as auditory dys-synchrony, is related to neuropathy and sensorineural hearing loss. An important gene associated with Auditory Neuropathy is DIAPH3 (diaphanous-related formin 3), and among its related pathways are Gap junction trafficking and Membrane Trafficking. The compounds 10panx and scrambled 10panx have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are hearing/vestibular/ear and nervous system.

Aliases & Classifications for Auditory Neuropathy

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Sources:
42NIH Rare Diseases, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

auditory neuropathy 42 60
auditory dys-synchrony 42


Related Diseases for Auditory Neuropathy

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Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Auditory Neuropathy:



Diseases related to auditory neuropathy

Clinical Features for Auditory Neuropathy

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Drugs & Therapeutics for Auditory Neuropathy

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Auditory Neuropathy

Search NIH Clinical Center for Auditory Neuropathy

Search CenterWatch for Auditory Neuropathy

Genetic Tests for Auditory Neuropathy

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Anatomical Context for Auditory Neuropathy

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Sources:
32MalaCards
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MalaCards organs/tissues related to Auditory Neuropathy:

32
Brain

Animal Models for Auditory Neuropathy or affiliated genes

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36MGI
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MGI Mouse Phenotypes related to Auditory Neuropathy:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053778.8GSC, OTOF, GJB2, GJB6, DFNB59
2MP:00036318.3MPZ, GRIA3, GJB6, GJB2, OTOF, GSC

Publications for Auditory Neuropathy

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Genetic Variations for Auditory Neuropathy

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Expression for genes affiliated with Auditory Neuropathy

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Auditory Neuropathy

Search GEO for disease gene expression data for Auditory Neuropathy.

Pathways for genes affiliated with Auditory Neuropathy

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53Reactome
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Pathways related to Auditory Neuropathy according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
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9.9GJB2, GJB6
29.4GJB2, GJB6, PICALM

Compounds for genes affiliated with Auditory Neuropathy

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Sources:
59Tocris Bioscience, 28IUPHAR, 24HMDB, 44Novoseek, 2BitterDB, 11DrugBank
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Compounds related to Auditory Neuropathy according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
110panx5910.0GJB2, GJB6
2scrambled 10panx5910.0GJB2, GJB6
3carbenoxolone disodium5910.0GJB2, GJB6
4gap 27599.9GJB2, GJB6
5octanol28 2410.9GJB6, GJB2
6flufenamic acid44 28 2 1112.9GJB2, GJB6
7carbenoxolone28 44 1111.8GJB2, GJB6
8ca2+289.6GJB2, GJB6

GO Terms for genes affiliated with Auditory Neuropathy

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Sources:
16Gene Ontology
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Cellular components related to Auditory Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1connexon complexGO:0059229.9GJB2, GJB6

Biological processes related to Auditory Neuropathy according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1sensory perception of soundGO:0076059.4OTOF, GJB2, GJB6, DFNB59

Products for genes affiliated with Auditory Neuropathy

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Auditory Neuropathy

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet