MCID: ATS172
MIFTS: 16

Autism 10

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Autism 10

MalaCards integrated aliases for Autism 10:

Name: Autism 10 54

Classifications:



External Ids:

OMIM 54 611016

Summaries for Autism 10

OMIM : 54
Autism, the prototypic pervasive developmental disorder (PDD), is usually apparent by 3 years of age. It is characterized by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypic, and ritualized patterns of interests and behavior (Bailey et al., 1996; Risch et al., 1999). 'Autism spectrum disorder,' sometimes referred to as ASD, is a broader phenotype encompassing the less severe disorders Asperger syndrome (see ASPG1; 608638) and pervasive developmental disorder, not otherwise specified (PDD-NOS). 'Broad autism phenotype' includes individuals with some symptoms of autism, but who do not meet the full criteria for autism or other disorders. Mental retardation coexists in approximately two-thirds of individuals with ASD, except for Asperger syndrome, in which mental retardation is conspicuously absent (Jones et al., 2008). Genetic studies in autism often include family members with these less stringent diagnoses (Schellenberg et al., 2006). For a discussion of genetic heterogeneity of autism, see 209850. (611016)

MalaCards based summary : Autism 10 The drugs Valproic Acid and Aripiprazole have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone.

Related Diseases for Autism 10

Diseases in the Autism Spectrum Disorder family:

Autism 19 Autism 9
Autism 10 Autism 18

Symptoms & Phenotypes for Autism 10

Clinical features from OMIM:

611016

Drugs & Therapeutics for Autism 10

Drugs for Autism 10 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 171)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Valproic Acid Approved, Investigational Phase 4,Phase 2 99-66-1 3121
2
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 2 129722-12-9 60795
3
Milnacipran Approved Phase 4 92623-85-3 65833
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
5
Methylphenidate Approved, Investigational Phase 4,Phase 3,Phase 2 113-45-1 4158
6
Risperidone Approved, Investigational Phase 4,Phase 2,Phase 3 106266-06-2 5073
7
Ziprasidone Approved Phase 4 146939-27-7 60854
8
Melatonin Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 73-31-4 896
9 Anticonvulsants Phase 4,Phase 2
10 Antimanic Agents Phase 4,Phase 2
11 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Phase 1
12 GABA Agents Phase 4,Phase 2
13 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1
14 Psychotropic Drugs Phase 4,Phase 3,Phase 2
15 Tranquilizing Agents Phase 4,Phase 3,Phase 2
16 Antipsychotic Agents Phase 4,Phase 3,Phase 2
17 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
18 Adrenergic Agents Phase 4,Phase 3,Phase 2
19 Atomoxetine Hydrochloride Phase 4,Phase 3
20 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3,Phase 2
21 Antidepressive Agents Phase 4,Phase 2
22
Serotonin Phase 4,Phase 2,Phase 1 50-67-9 5202
23 Serotonin Agents Phase 4,Phase 2,Phase 1
24 Serotonin Uptake Inhibitors Phase 4,Phase 2
25 Central Nervous System Stimulants Phase 4,Phase 3,Phase 2
26 Dopamine Agents Phase 4,Phase 3,Phase 2,Phase 1
27 Dopamine Uptake Inhibitors Phase 4,Phase 3,Phase 2
28 Antioxidants Phase 4,Phase 2,Phase 3,Phase 1
29 Protective Agents Phase 4,Phase 2,Phase 3,Phase 1
30 Dopamine Antagonists Phase 4
31 Serotonin Antagonists Phase 4
32 Quetiapine Fumarate Phase 4 111974-72-2
33
Everolimus Approved Phase 2, Phase 3,Phase 1 159351-69-6 6442177
34
Miconazole Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 1 22916-47-8 4189
35
Sirolimus Approved, Investigational Phase 2, Phase 3,Phase 1 53123-88-9 5284616 6436030 46835353
36
Adenosine Approved, Investigational Phase 2, Phase 3 58-61-7 60961
37
Metformin Approved Phase 3 657-24-9 14219 4091
38
Cycloserine Approved Phase 3 68-41-7 401 6234
39
Diphenhydramine Approved Phase 2, Phase 3 58-73-1, 147-24-0 3100
40
Fluoxetine Approved, Vet_approved Phase 2, Phase 3 54910-89-3 3386
41
Promethazine Approved Phase 2, Phase 3 60-87-7 4927
42
Levoleucovorin Approved Phase 3,Phase 2 68538-85-2
43
Bisacodyl Approved Phase 3 603-50-9
44
Glycerol Approved, Investigational Phase 3 56-81-5 753
45
Acamprosate Approved, Investigational Phase 2, Phase 3 77337-76-9 71158
46
Ethanol Approved Phase 2, Phase 3 64-17-5 702
47
Memantine Approved, Investigational Phase 3 19982-08-2 4054
48 Tocopherol Approved, Nutraceutical Phase 3,Phase 2
49
Vitamin C Approved, Nutraceutical Phase 3,Phase 2 50-81-7 5785 54670067
50
Vitamin E Approved, Nutraceutical, Vet_approved Phase 3,Phase 2 59-02-9 14985

Interventional clinical trials:

(show top 50) (show all 155)

id Name Status NCT ID Phase Drugs
1 Divalproex Sodium ER in Adult Autism Unknown status NCT00211796 Phase 4 Divalproex Sodium ER
2 Study to Evaluate the Efficacy and Safety of Aripiprazole Unknown status NCT02069977 Phase 4 Aripiprazole
3 Atomoxetine, Placebo and Parent Management Training in Autism Completed NCT00844753 Phase 4 atomoxetine;Placebo
4 Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism Completed NCT01337700 Phase 4 Milnacipran;Placebo
5 Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study Completed NCT02255565 Phase 4 Very Low Dose Quillivant XR;Low Dose Quillivant XR;Moderate Dose Quillivant XR
6 Melatonin CR for the Treatment of Impaired Sleep Maintenance in 4-8 Year Old Children With Autism Spectrum Disorders Terminated NCT01033565 Phase 4 Natrol
7 1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain Terminated NCT01844700 Phase 4 Ziprasidone;aripiprazole, quetiapine, or risperidone
8 Efficacy of RAD001/Everolimus in Autism and NeuroPsychological Deficits in Children With Tuberous Sclerosis Complex Unknown status NCT01730209 Phase 2, Phase 3 Everolimus;Placebo
9 A Pilot Study of Daytrana TM in Children With Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms Completed NCT00541346 Phase 3 Methylphenidate Transdermal System
10 Treatment of Overweight Induced by Antipsychotic Medication in Young People With Autism Spectrum Disorders (ASD) Completed NCT01825798 Phase 3 Metformin;Placebo
11 Study of Aripiprazole in the Treatment of Serious Behavioral Problems in Children and Adolescents With Autistic Disorder (AD) Completed NCT00365859 Phase 3 Aripiprazole
12 Effectiveness of Atomoxetine in Treating ADHD Symptoms in Children and Adolescents With Autism Completed NCT00498173 Phase 3 Atomoxetine;Placebo
13 Methylphenidate for Attention Deficit Hyperactivity Disorder and Autism in Children Completed NCT00178503 Phase 2, Phase 3 Methylphenidate-extended release;Methylphenidate-immediate release
14 Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD) Completed NCT00332241 Phase 3 Aripiprazole;Placebo
15 Safety and Effectiveness of D-Cycloserine in Children With Autism Completed NCT00198120 Phase 3 D-cycloserine;Placebo
16 Study of Aripiprazole in the Treatment of Children and Adolescents With Autistic Disorder (AD) Completed NCT00337571 Phase 3 Aripiprazole;Placebo
17 Understanding Sleep Problems in Children With Autism Spectrum Disorder Completed NCT00691080 Phase 2, Phase 3
18 Evaluating the Effectiveness of Aripiprazole and D-Cycloserine to Treat Symptoms Associated With Autism Completed NCT00198107 Phase 3 Aripiprazole;Placebo;D-cycloserine
19 Study of Acamprosate in Autism Recruiting NCT01813318 Phase 2, Phase 3 Acamprosate;Placebo
20 Behavioral and Neural Response to Memantine in Adolescents With Autism Spectrum Disorder Recruiting NCT01972074 Phase 3 Memantine;Placebo
21 Clinical Trial for Asses the Safety and Efficacy of Vitamin C and Vitamin E in Combination Versus Placebo for Treating Cognitive and Behavior Disorder in Children With Fragile X Syndrome Recruiting NCT02942498 Phase 3 Vitamin C 10mg/Kg Vitamin E 10 mg/Kg;Placebo
22 Efficacy and Safety of Circadin® in the Treatment of Sleep Disturbances in Children With Neurodevelopment Disabilities Active, not recruiting NCT01906866 Phase 3 Circadin 2/5/10 mg;Placebo
23 Folinic Acid and Language Impairment in Autism Spectrum Disorder Not yet recruiting NCT02839915 Phase 3 Folinic Acid
24 Encopresis & MIE (DoD #2) Not yet recruiting NCT03197922 Phase 3
25 A Clinical Trial to Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Autism Unknown status NCT01836562 Phase 1, Phase 2
26 Nuedexta for the Treatment of Adults With Autism Unknown status NCT01630811 Phase 2 Nuedexta
27 A Study of RG7314 to Investigate Efficacy and Safety in Individuals With Autism Spectrum Disorders (ASD) Completed NCT01793441 Phase 2 Placebo;RG7314
28 Sulforaphane-rich Broccoli Sprout Extract for Autism Completed NCT01474993 Phase 2 Sulforaphane-rich Broccoli Sprout Extract;Placebo
29 Dimercaptosuccinic Acid (DMSA) Treatment of Children With Autism and Heavy Metal Toxicity Completed NCT00811083 Phase 1, Phase 2 DMSA - dimercaptosuccinic acid
30 A Study of Pregnenolone in the Treatment of Individuals With Autism Completed NCT01881737 Phase 2 Pregnenolone
31 Nutritional Intervention in Children With Autism Using Whey Protein (Immunocal): Impact on Core Areas of Behavior Completed NCT01366859 Phase 2
32 Effects of the Anti-inflammatory Flavonoid Luteolin on Behavior in Children With Autism Spectrum Disorders Completed NCT01847521 Phase 2
33 Donepezil HCl & Cognitive Deficits in Autism Completed NCT00047697 Phase 2 Donepezil HCl;Placebo
34 A Study of Oral N-Acetylcysteine in Children With Autism Spectrum Disorders Completed NCT00453180 Phase 2 N-acetylcysteine;Placebo
35 Trial of RAD001 and Neurocognition in Tuberous Sclerosis Complex (TSC) Completed NCT01289912 Phase 2 RAD001
36 Autologous Cord Blood Stem Cells for Autism Completed NCT01638819 Phase 2
37 Intranasal Oxytocin for the Treatment of Children and Adolescents With ASD (OXY) Completed NCT01256060 Phase 2 Intranasal Oxytocin
38 Dose Finding Study of Pioglitazone in Children With Autism Spectrum Disorders (ASD) (PIO) Completed NCT01205282 Phase 2 Pioglitazone;Placebo
39 The Effect of Donepezil (Aricept(Registered Trademark)) on REM Sleep in Children With Autism Completed NCT00695136 Phase 1, Phase 2 Donepezil hydrochloride
40 Targeting GABA-A for the Treatment of Social Disability in Young Adults With Autism Spectrum Disorders: A Phase II Proof of Mechanism Trial Completed NCT01966679 Phase 2 AZD7325;Placebo
41 Riluzole to Treat Child and Adolescent Obsessive-Compulsive Disorder With or Without Autism Spectrum Disorders Completed NCT00251303 Phase 2 Riluzole;Placebo
42 Open-Label Study of the Safety and Tolerability of STX209 in Subjects With Autism Spectrum Disorders Completed NCT00846547 Phase 2 Arbaclofen
43 A Study of Aripiprazole in Children and Adolescents With Aspergers and Pervasive Developmental Disorder. Completed NCT00198055 Phase 2 aripiprazole
44 Citalopram for Children With Autism and Repetitive Behavior (STAART Study 1) Completed NCT00086645 Phase 2 citalopram hydrobromide
45 Melatonin Dose-effect Relation in Childhood Autism Completed NCT01780883 Phase 2 melatonin;Placebo
46 A Study of Oxytocin in Children and Adolescents With Autistic Disorder Completed NCT01308749 Phase 2 Oxytocin;Placebo
47 Randomized Controlled Study of Donepezil in Fragile X Syndrome Completed NCT01120626 Phase 2 donepezil;sugar pill
48 Safety and Efficacy Study of Antioxidants for the Treatment of the Fragile X Syndrome Completed NCT01329770 Phase 2
49 A Study to Investigate the Efficacy and Safety of RO5285119 in Participants With Autism Spectrum Disorder (ASD) Recruiting NCT02901431 Phase 2 Placebo;RO5285119
50 Folinic Acid in Children With Autism Spectrum Disorders Recruiting NCT02551380 Phase 2 FOLINORAL

Search NIH Clinical Center for Autism 10

Genetic Tests for Autism 10

Anatomical Context for Autism 10

MalaCards organs/tissues related to Autism 10:

39
Brain, Testes, Bone

Publications for Autism 10

Variations for Autism 10

Expression for Autism 10

Search GEO for disease gene expression data for Autism 10.

Pathways for Autism 10

GO Terms for Autism 10

Sources for Autism 10

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60 QIAGEN
65 SNOMED-CT via HPO
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67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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