MCID: ATS170
MIFTS: 17

Autism 19

Categories: Genetic diseases, Rare diseases, Mental diseases

Aliases & Classifications for Autism 19

MalaCards integrated aliases for Autism 19:

Name: Autism 19 54 71
Autism, Susceptibility to, 19 29 13
Auts19 71

Classifications:



External Ids:

OMIM 54 615091
MeSH 42 D001321

Summaries for Autism 19

UniProtKB/Swiss-Prot : 71 Autism 19: A complex multifactorial, pervasive developmental disorder characterized by impairments in reciprocal social interaction and communication, restricted and stereotyped patterns of interests and activities, and the presence of developmental abnormalities by 3 years of age. Most individuals with autism also manifest moderate mental retardation.

MalaCards based summary : Autism 19, is also known as autism, susceptibility to, 19. An important gene associated with Autism 19 is EIF4E (Eukaryotic Translation Initiation Factor 4E). The drugs Fluvoxamine and Sertraline have been mentioned in the context of this disorder.

Description from OMIM: 615091

Related Diseases for Autism 19

Diseases in the Autism Spectrum Disorder family:

Autism 19 Autism 9
Autism 10 Autism 18

Symptoms & Phenotypes for Autism 19

Clinical features from OMIM:

615091

Drugs & Therapeutics for Autism 19

Drugs for Autism 19 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluvoxamine Approved, Investigational Phase 3 54739-18-3 3404 5324346
2
Sertraline Approved Phase 3 79617-96-2 68617
3 Cytochrome P-450 Enzyme Inhibitors Phase 3
4 Anti-Anxiety Agents Phase 3
5 Antidepressive Agents Phase 3
6 Antidepressive Agents, Second-Generation Phase 3
7 Central Nervous System Depressants Phase 3,Phase 2
8 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
9 Neurotransmitter Agents Phase 3,Phase 2
10 Neurotransmitter Uptake Inhibitors Phase 3
11 Psychotropic Drugs Phase 3,Phase 2
12
Serotonin Phase 3,Phase 2 50-67-9 5202
13 Serotonin Agents Phase 3,Phase 2
14 Serotonin Uptake Inhibitors Phase 3
15 Tranquilizing Agents Phase 3,Phase 2
16
Dopamine Approved Phase 2 51-61-6, 62-31-7 681
17 Adrenergic Agents Phase 2
18 Adrenergic alpha-Antagonists Phase 2
19 Adrenergic Antagonists Phase 2
20 Antipsychotic Agents Phase 2
21 Dopamine Agents Phase 2
22 Dopamine Antagonists Phase 2
23 Dopamine D2 Receptor Antagonists Phase 2
24
Lurasidone hydrochloride Phase 2 367514-87-2 213046
25 Serotonin 5-HT2 Receptor Antagonists Phase 2
26 Serotonin Antagonists Phase 2
27
Fluconazole Approved 86386-73-4 3365
28
Miconazole Approved, Investigational, Vet_approved 22916-47-8 4189
29
Oxytocin Approved, Vet_approved Early Phase 1 50-56-6 439302 53477758
30
Menthol Approved 2216-51-5 16666
31 Antifungal Agents
32 Anti-Infective Agents
33 Cytochrome P-450 CYP2C9 Inhibitors
34 Hormone Antagonists
35 Hormones
36 Hormones, Hormone Substitutes, and Hormone Antagonists
37 Steroid Synthesis Inhibitors
38 Oxytocics Early Phase 1

Interventional clinical trials:


id Name Status NCT ID Phase Drugs
1 Fluvoxamine and Sertraline in Childhood Autism - Does SSRI Therapy Improve Behaviour and/or Mood? Completed NCT00655174 Phase 3 fluvoxamine;sertraline;Placebo
2 Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents Completed NCT01731119 Phase 2 Latuda©
3 Rehabilitation of Children With Multiple Disabilities Completed NCT01379443 Phase 1
4 Study of Fluconazole in Children With Autism Spectrum Disorder Unknown status NCT00936182 Fluconazole
5 Multisensorial Information's Treatment in Autism Spectrum Disorder Completed NCT02579109
6 Oxytocin Effect on Attentional Bias Towards Emotional Expression Faces in Individuals With High and Low Autistic Traits: A Functional Magnetic Resonance Imaging (fMRI) Study Recruiting NCT02741063 Early Phase 1 oxytocin;placebo
7 Comparative Efficacy of Self-directed & Therapist-assisted Telehealth Parent Training Intervention for Children With ASD Recruiting NCT02721381
8 Clinical and Neurophysiological Evolutions Through a Functional Rehabilitation of Social Communication in ASD Recruiting NCT02444117
9 MRI Study of Cerebral Blood Flow in Development Disorders in Children Recruiting NCT02165410

Search NIH Clinical Center for Autism 19

Genetic Tests for Autism 19

Genetic tests related to Autism 19:

id Genetic test Affiliating Genes
1 Autism, Susceptibility to, 19 29

Anatomical Context for Autism 19

Publications for Autism 19

Variations for Autism 19

ClinVar genetic disease variations for Autism 19:

6
id Gene Variation Type Significance SNP ID Assembly Location
1 EIF4E EIF4E, 1-BP INS, -25C insertion risk factor

Expression for Autism 19

Search GEO for disease gene expression data for Autism 19.

Pathways for Autism 19

GO Terms for Autism 19

Sources for Autism 19

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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