Autism Spectrum Disorder malady

CDC: Autism is one of a group of disorders known as autism spectrum disorders (ASDs). ASDs include autistic disorder, pervasive developmental disorder – not otherwise specified (PDD-NOS, including atypical autism), and Asperger syndrome. These conditions all have some of the same symptoms, but they differ in terms of when the symptoms start, how severe they are, and the exact nature of the symptoms.²

MalaCards: Autism Spectrum Disorder, also known as autism spectrum disorders, is related to asperger syndrome and schizophrenia, and has symptoms including widespread abnormalities of social interactions, severely restricted interests and highly repetitive behavior. An important gene associated with Autism Spectrum Disorder is SEZ6L2 (seizure related 6 homolog (mouse)-like 2), and among its related pathways are Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q and Class A/1 (Rhodopsin-like receptors). The compounds glucose and haloperidol have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and t cells, and related mouse phenotypes are endocrine/exocrine gland and hematopoietic system.

Disease Ontology: A pervasive developmental disorder that is a spectrum of psychological conditions. the disease has symptom widespread abnormalities of social interactions and communication, has symptom severely restricted interests and has symptom highly repetitive behavior.⁶

Wikipedia: The autism spectrum or autistic spectrum describes a range of conditions classified as pervasive...⁴⁴ more...

GeneReviews summary for autism-overview

autism spectrum disorder 6 autism spectrum disorders 15 16 43

pdd 16

Diseases related to autism spectrum disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 487)

id	Related Disease	Score	Top Affiliating Genes
1	asperger syndrome	34.5	ASPG1, MECP2, DISC1, NLGN3, NLGN4X, SHANK3
2	schizophrenia	32.6	MTHFR, HTR2A, DRD3, DISC1, COMT
3	pervasive developmental disorder	32.3	SCT, FOXP2, MECP2, RPL10, NLGN3, NLGN4X
4	atypical autism	32.3	NLGN3, NLGN4X, OXTR, GABRB3
5	autistic disorder	32.0	NDN, RELN, BDNF, SCT, UBE3A, FOXP2
6	adhd	30.4	CNR1, BDNF, CHRNA7, CHRNA4, AR, GRIN2A
7	anxiety disorder	30.0	CNR1, BDNF, MAOA, MAOB, CCK, HTR2A
8	intellectual disability	29.0	ZNF711, RELN, CNTN4, CNTNAP2, PCDH19, BDNF
9	adenomatous polyposis coli	28.1	PIK3CG, BCL2, MUC1, UBE3A, AR, APC
10	polyposis	26.1	PIK3CG, BCL2, MUC1, UBE3A, AR, IL1RN
11	cerebritis	22.4	PIK3CG, RELN, CNR1, CNTN4, CNTNAP2, RASGRP1
12	dementia	22.0	PIK3CG, RELN, PARK2, BDNF, BCL2, CHRNA7
13	advanced sleep phase syndrome	14.3	GPR50, TPH2, DAOA, HCRT, CSN1S1, CSNK1E
14	generalized epilepsy with febrile seizures plus	14.1	PCDH19, CHRNA7, CHRNA4, GRIK2, MAOA, CACNA1H
15	hypotonia	14.0	NDN, UBE3A, ASPA, MECP2, MAOA, MAOB
16	conduction disease	14.0	MAOA, DRD4, DRD5, DBH, SLC6A3, SLC6A4
17	idiopathic generalized epilepsy	14.0	CHRNA7, CHRNA4, GRIK2, MAOA, CACNA1H, SLC12A6
18	antisocial personality disorder	14.0	MAOA, HTR1B, HTR2A, HTR3B, DRD2, DRD4
19	mecp2-related severe neonatal encephalopathy	14.0	MECP2, OXT, ADSL
20	mental retardation, x-linked	14.0	ZNF711, RAB39B, KDM5C, ATRX, MECP2, IL1RAPL1
21	hermaphroditism	14.0	FOXP2, AR, MCHR1, HTR1B, HTR1E, TPH2
22	pathological gambling	13.9	MAOA, MAOB, DRD1, DRD2, DRD3, DRD4
23	manic-depressive illness	13.9	INPP1, MAOA, MAOB, DRD2, DRD3, DRD4
24	developmental disabilities	13.9	BDNF, SCT, UBE3A, FOXP2, MECP2, MAOA
25	ganglioglioma	13.9	RELN, GFAP, TSC1, TSC2, NSD1, SLC1A1
26	post-traumatic stress disorder	13.9	CNR1, BDNF, MAOA, DRD2, DBH, NPY
27	endogenous depression	13.9	BDNF, DRD3, SLC6A4, GAD1
28	generalized anxiety disorder	13.9	MAOA, HTR2A, HTR2C, NPY, SLC6A2, SLC6A4
29	dysthymic disorder	13.9	MAOA, HTR2A, HCRT
30	personality disorder	13.9	MAOA, MAOB, HTR1B, TPH2, DRD2, DRD3
31	novelty seeking personality	13.9	MAOA, DRD2, DRD4, COMT, SLC6A2
32	opiate dependence	13.9	DRD2, DRD3, OPRD1, OPRK1
33	drug addiction	13.9	BDNF, DRD1, DRD2, DRD3, HCRT, OPRD1
34	social phobia	13.9	MAOA, DRD2, COMT, OXT, SLC6A4
35	cognitive disease	13.9	RELN, CHRNA7, MAOA, MAOB, COMT
36	bulimia nervosa	13.8	MC4R, CCK, GHRL
37	gastrointestinal system disease	13.8	SCT, MIF, CCK, GHRL, PYY
38	insomnia	13.8	LEP, ASMT, HTR2A, HTR2C, GHRL, HCRT
39	memory impairment	13.8	CNR1, BDNF, MAOB, HTR2A, DRD1, SLC6A3
40	intractable epilepsy	13.8	BDNF, LAMB1, GFAP, TSC1, TSC2, SLC6A8
41	central nervous system disease	13.8	CNR1, BDNF, CHRNA7, HTR2A, HCRT, GFAP
42	recessive developmental delay, small stature, microcephaly and brain calcifications	13.8	ASPA, MECP2, DDC, TSC1, DPYD, NSD1
43	neurotic disorder	13.8	BDNF, MAOA, HTR2A, DRD2, DRD3, DRD4
44	subependymal giant cell astrocytoma	13.8	CCK, GFAP, TSC1, TSC2, NPY
45	carcinoid syndrome	13.8	SCG5, SCT, MUC1, MAOA, CCK, HTR2A
46	migraine with aura	13.7	MTHFR, HTR1B, HTR2A, HTR2C, DRD2, DBH
47	phenylketonuria	13.7	MTHFR, MAOB, GHRL, DRD2, HCRT, CSN1S1
48	morbid obesity	13.7	RETN, LEP, LEPR, MC3R, MC4R, CCK
49	liver cirrhosis	13.7	RETN, CNR1, CNR2, SCT, LEPR, AVP
50	neuroendocrine tumor	13.7	SCT, CCK, GHRL, GHSR, DRD2, PYY

Symptoms: widespread abnormalities of social interactions, severely restricted interests, highly repetitive behavior.⁶

Approved drugs:

Drug clinical trials:

Genetic tests related to autism spectrum disorder:

id	Genetic test	Affiliating Genes
1	Autism Spectrum Disorder clinical/research	PTCHD1, SNRPN, NOV, RPL10, NLGN3, NLGN4X, SHANK2, SHANK3

MalaCards organs/tissues related to autism spectrum disorder:

²²

MGI Mouse Phenotypes related to autism spectrum disorder:

²⁵ (show all 27)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	11.1	SCG5, CHRM5, MECP2, APAF1, MCPH1, HTR1B
2	hematopoietic system phenotype	MP:0005397	10.5	RASGRP1, BCL2, MTF1, AVPR1A, FOXP2, MIF
3	no phenotypic analysis	MP:0003012	10.3	NDN, CNR1, BDNF, LEPR, CHRNA4, MUC1
4	liver/biliary system phenotype	MP:0005370	10.2	RETN, RASGRP1, SCG5, MTF1, MKL2, AR
5	normal phenotype	MP:0002873	10.2	COBL, NDN, SEZ6L2, BDNF, KDM5C, LEPR
6	embryogenesis phenotype	MP:0005380	10.2	KDM5C, CEP41, ATRX, ATP6V0C, FOXO1, FOXP2
7	respiratory system phenotype	MP:0005388	9.8	NDN, PARK2, BDNF, KCNN3, SCG5, LEPR
8	taste/olfaction phenotype	MP:0005394	9.6	CNR1, CNTNAP2, BDNF, CASP3, CASP9, TPH2
9	hearing/vestibular/ear phenotype	MP:0005377	9.6	BDNF, BCL2, FOXP2, MECP2, APAF1, APC
10	renal/urinary system phenotype	MP:0005367	9.4	RASGRP1, BCL2, LEPR, AVP, AR, MET
11	immune system phenotype	MP:0005387	9.3	CNR2, RASGRP1, SCG5, LEPR, CHRNA7, CHRNA4
12	skeleton phenotype	MP:0005390	8.8	PIK3CG, CNR1, PARK2, LEP, LEPR, MTHFR
13	reproductive system phenotype	MP:0005389	8.7	KCNN3, LEP, LEPR, UBE3A, ATRX, MECP2
14	adipose tissue phenotype	MP:0005375	8.4	RETN, CNR1, BCL2, SCG5, LEP, LEPR
15	vision/eye phenotype	MP:0005391	8.2	RELN, BDNF, BCL2, LEP, LEPR, MUC1
16	digestive/alimentary phenotype	MP:0005381	8.2	RELN, BDNF, BCL2, LEP, LEPR, CHRM5
17	tumorigenesis	MP:0002006	7.8	BCL2, LEP, LEPR, MUC1, MTF1, FOXO1
18	cardiovascular system phenotype	MP:0005385	7.7	PIK3CG, BCL2, SCG5, LEP, LEPR, CHRM5
19	homeostasis/metabolism phenotype	MP:0005376	6.8	PIK3CG, NDN, RETN, CNR1, PARK2, BDNF
20	cellular phenotype	MP:0005384	6.5	PIK3CG, NDN, RELN, CNR1, CNTNAP2, RASGRP1
21	muscle phenotype	MP:0005369	INF	PIK3CG, NDN, RELN, PARK2, BCL2, LEP
22	behavior/neurological phenotype	MP:0005386	INF	NDN, RELN, CNR1, CNTNAP2, SEZ6L2, BDNF
23	integument phenotype	MP:0010771	INF	PIK3CG, NDN, RELN, CNR1, CNR2, CNTNAP2
24	mortality/aging	MP:0010768	INF	NDN, RELN, CNR1, PARK2, BDNF, KCNN3
25	craniofacial phenotype	MP:0005382	INF	BDNF, FOXO1, FOXP2, ASPA, MKL2, MECP2
26	growth/size phenotype	MP:0005378	INF	PIK3CG, RELN, CNR1, CNTNAP2, PARK2, BDNF
27	nervous system phenotype	MP:0003631	INF	COBL, NDN, RELN, CNR1, CNTNAP2, SEZ6L2

Articles related to autism spectrum disorder:

(show top 50)    (show all 125)

id	Title	Authors	Year	Affiliating Genes
1	Variations of the candidate SEZ6L2 gene on Chromosome 16p11.2 in patients with autism spectrum disorders and in human populations. (21394203)	Konyukh M.... Bourgeron T.	2011	SEZ6L2
2	Gene expression in blood is associated with risperido ne response in children with autism spectrum disorders. (21647175)	Lit L.... Hendren R.L.	2011	RNF213
3	An integrated meta-analysis of two variants in HOXA1/ HOXB1 and their effect on the risk of autism spectrum disorders. (21980499)	Song R.R.... Miao X.P.	2011	HOXA1, HOXB1
4	MAOA, DBH, and SLC6A4 variants in CHARGE: a case-cont rol study of autism spectrum disorders. (21538940)	Tassone F.... Hertz-Picciotto I.	2011	MAOA, DBH, SLC6A4
5	A sex-specific association of common variants of neur oligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort. (21569590)	Yu J.... Zhao Z.	2011	NLGN3
6	SNAP-25 single nucleotide polymorphisms are associate d with hyperactivity in autism spectrum disorders. (21497654)	Guerini F.R.... Clerici M.	2011	SNAP25
7	Common genetic variation in the GAD1 gene and the ent ire family of DLX homeobox genes and autism spectrum disorders. (21302352)	Chang S.C.... Santangelo S.L.	2011	GAD1
8	PARK2 copy number aberrations in two children present ing with autism spectrum disorder: further support of an association and possib le evidence for a new microdeletion/microduplication syndrome. (21360662)	Scheuerle A.... Wilson K.	2011	PARK2
9	No association between a common single nucleotide pol ymorphism, rs4141463, in the MACROD2 gene and autism spectrum disorder. (21656903)	Curran S.... Collier D.	2011	MACROD2
10	Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (AS D). (21384559)	KantojAorvi K.... JAorvelAo I.	2011	ACSL4, RPS6KA6, DLG3
11	5-HTTLPR polymorphism influences prefrontal neurochem ical metabolites in autism spectrum disorder. (20619617)	Endo T.... Someya T.	2010	SLC6A4
12	MTHFR C677T is not a risk factor for autism spectrum disorders in South Brazil. (20440228)	dos Santos P.A.... SchA1ler-Faccini L.	2010	MTHFR
13	Disruption of CNTNAP2 and additional structural genom e changes in a boy with speech delay and autism spectrum disorder. (19582487)	Poot M.... Haaf T.	2010	CNTNAP2
14	Intragenic rearrangements in NRXN1 in three families with autism spectrum disorder, developmental delay, and speech delay. (20162629)	WiA9niowiecka-Kowalnik B.... Stankiewicz P.	2010	NRXN1
15	Expression analyses of the mitochondrial complex I 75 -kDa subunit in early onset schizophrenia and autism spectrum disorder: increas ed levels as a potential biomarker for early onset schizophrenia. (19894076)	Taurines R.... Mehler-Wex C.	2010	NDUFS4
16	Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. (20844286)	Noor A.... Vincent J.B.	2010	PTCHD1, LOC100873065
17	Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation. (20473310)	Berkel S.... Rappold G.A.	2010	SHANK2
18	Family-based association study of microsatellites in the 5' flanking region of AVPR1A with autism spectrum disorder in the Korean po pulation. (20452058)	Yang S.Y.... Kim S.A.	2010	AVPR1A
19	Brief Report: Glutamate Transporter Gene (SLC1A1) Sin gle Nucleotide Polymorphism (rs301430) and Repetitive Behaviors and Anxiety in Children with Autism Spectrum Disorder. (20155310)	Gadow K.D.... Hatchwell E.	2010	SLC1A1
20	Screening for genomic rearrangements and methylation abnormalities of the 15q11-q13 region in autism spectrum disorders. (19278672)	Depienne C.... Betancur C.	2009	PAR5
21	The prevalence of PTEN mutations in a clinical pediatric cohort with autism spectrum disorders, developmental delay, and macrocephaly. (19265751)	Varga E.A.... McBride K.L.	2009	PTEN
22	Serotonin transporter genotype and neuroanatomy in autism spectrum disorders. (19369912)	Raznahan A.... Murphy D.G.	2009	SLC6A4
23	The DLX1and DLX2 genes and susceptibility to autism spectrum disorders. (18728693)	Liu X.... Holden J.J.	2008	DLX2, DLX1
24	Genetic evidence implicating multiple genes in the MET receptor tyrosine kinase pathway in autism spectrum disorder. (19360663)	Campbell D.B.... Levitt P.	2008	MET, SP1
25	Genetic analysis of reelin gene (RELN) SNPs: No association with autism spectrum disorder in the Indian population. (18597938)	Dutta S.... Usha R.	2008	RELN
26	Association between PTGS2 polymorphism and autism spectrum disorders in Korean trios. (18579107)	Yoo H.J.... Kim S.A.	2008	PTGS2
27	Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: Efficient identification of known microduplications and identification of a novel microduplication in ASMT. (18925931)	Cai G.... Buxbaum J.D.	2008	ASPA
28	No association between common variants in glyoxalase 1 and autism spectrum disorders. (17722011)	Rehnstrom K.... Hovatta I.	2008	GLO1
29	No evidence for involvement of genetic variants in the X-linked neuroligin genes NLGN3 and NLGN4X in probands with autism spectrum disorder on high functioning level. (18189281)	Wermter A.K.... Remschmidt H.	2008	NLGN3, NLGN4X
30	The G22A polymorphism of the ADA gene and susceptibility to autism spectrum disorders. (17340203)	Hettinger J.A.... Holden J.J.	2008	ADA
31	Hypo-phosphorylation of salivary peptidome as a clue to the molecular pathogenesis of autism spectrum disorders. (19367726)	Castagnola M.... Gurrieri F.	2008	STATH, HTN1, PRAP1
32	Analysis of X chromosome inactivation in autism spectrum disorders. (18361425)	Gong X.... Bourgeron T.	2008	ATRX
33	Screening of male patients with autism spectrum disorder for creatine transporter deficiency. (18461508)	Newmeyer A.... Salomons G.	2007	SLC6A8
34	Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios. (17428563)	Kim S.A.... Yoo H.J.	2007	GRIK2
35	Family-based association study of 5-HTTLPR and the 5-HT2A receptor gene polymorphisms with autism spectrum disorder in Korean trios. (17280648)	Cho I.H.... Kim S.A.	2007	SLC6A4, HTR2A
36	Sex differences in oxytocin and vasopressin: implicat ions for autism spectrum disorders? (17000015)	Carter C.S.	2007	OXT
37	Glutamate receptor 6 gene (GluR6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorder. (17712621)	Dutta S.... Usha R.	2007	GRIK2
38	Mutation analysis of the NSD1 gene in patients with autism spectrum disorders and macrocephaly. (18001468)	Buxbaum J.D.... Betancur C.	2007	NSD1
39	CACNA1H mutations in autism spectrum disorders. (16754686)	Splawski I.... Keating M.T.	2006	CACNA1H
40	Association of GABRB3 polymorphisms with autism spectrum disorders in Korean trios. (17230033)	Kim S.A.... Yoo H.J.	2006	GABRB3
41	Support for the homeobox transcription factor gene ENGRAILED 2 as an autism spectrum disorder susceptibility locus. (16252243)	Benayed R.... Millonig J.H.	2005	EN2
42	Evaluation of an association between gastrointestinal symptoms and cytokine production against common dietary proteins in children with autism spectrum disorders. (15870662)	Jyonouchi H.... Zimmerman-Bier B.	2005	CSN1S1
43	Increased repetitive behaviours and prolactin respons ivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders . (15132762)	Novotny S.... Iyengar R.	2004	PRL
44	Association of the homeobox transcription factor, ENGRAILED 2, 3, with autism spectrum disorder. (15024396)	Gharani N.... Millonig J.H.	2004	EN2
45	Multiple pathways regulate MeCP2 expression in normal brain development and exhibit defects in autism-spectrum disorders. (14734626)	Samaco R.C.... LaSalle J.M.	2004	MECP2
46	The transmission disequilibrium test suggests that HLA-DR4 and DR13 are linked to autism spectrum disorder. (12039413)	Torres A.R.... Odell D.	2002	HLA-DRB1
47	A genomewide screen for autism-spectrum disorders: evidence for a major susceptibility locus on chromosome 3q25-27. (12192642)	Auranen M.... Jarvela I.	2002	AUTS8, ASPG1
48	No association between HOXA1 and HOXB1 genes and autism spectrum disorders (ASD). (12414832)	Talebizadeh Z.... Butler M.G.	2002	HOXA1
49	Genetically determined low maternal serum dopamine beta-hydroxylase levels and the etiology of autism spectrum disorders. (11337745)	Robinson P.D.... Holden J.J.	2001	DBH
50	Metabolic approaches to the treatment of autism spectrum disorders. (11098885)	Page T.	2000	DPYD, ADSL

Genes related to autism spectrum disorder according to GeneCards:

(show top 50)    (show all 233)

id	Symbol	Description	Score	GeneCards Section Context
1	SEZ6L2	seizure related 6 homolog (mouse)-like 2	11.1	Summaries, Publications
2	SHANK3	SH3 and multiple ankyrin repeat domains 3	11.1	Summaries, Publications
3	CNTN4	contactin 4	11.1	Publications, Summaries
4	AUTS8	Autism, susceptibility to, 8	11.0	Publications
5	ASPG1	Asperger syndrome, susceptibility to, 1	11.0	Publications
6	HOXB@	homeobox B cluster	11.0	Publications
7	CHDS3	Coronary heart disease, susceptibility to, 3	11.0	Publications
8	PAR5	Prader-Willi/Angelman syndrome-5	11.0	Publications
9	HOXD@	homeobox D cluster	11.0	Publications
10	RPP25	ribonuclease P/MRP 25kDa subunit	11.0	Publications
11	ASMT	acetylserotonin O-methyltransferase	11.0	Publications
12	TMEM100	transmembrane protein 100	11.0	Publications
13	DDX53	DEAD (Asp-Glu-Ala-Asp) box polypeptide 53	11.0	Publications
14	GPRASP2	G protein-coupled receptor associated sorting protein 2	11.0	Publications
15	LRRTM3	leucine rich repeat transmembrane neuronal 3	11.0	Publications
16	LRRTM1	leucine rich repeat transmembrane neuronal 1	11.0	Publications
17	LRRN3	leucine rich repeat neuronal 3	11.0	Publications
18	UBL5	ubiquitin-like 5	11.0	Publications
19	NLGN3	neuroligin 3	11.0	Publications
20	GPR50	G protein-coupled receptor 50	11.0	Publications
21	DLX1	distal-less homeobox 1	11.0	Publications
22	EN2	engrailed homeobox 2	11.0	Publications
23	HOXB1	homeobox B1	11.0	Publications
24	SLITRK2	SLIT and NTRK-like family, member 2	11.0	Publications
25	STATH	statherin	11.0	Publications
26	DYX1C1	dyslexia susceptibility 1 candidate 1	11.0	Publications
27	PPP1R3F	protein phosphatase 1, regulatory subunit 3F	11.0	Publications
28	HOXA1	homeobox A1	11.0	Publications
29	FASTK	Fas-activated serine/threonine kinase	11.0	Publications
30	FIGNL1	fidgetin-like 1	11.0	Publications
31	HTN1	histatin 1	11.0	Publications
32	DLX2	distal-less homeobox 2	11.0	Publications
33	PRAP1	proline-rich acidic protein 1	11.0	Publications
34	HES6	hairy and enhancer of split 6 (Drosophila)	11.0	Publications
35	PTCHD1	patched domain containing 1	11.0	Publications
36	TM4SF20	transmembrane 4 L six family member 20	11.0	Publications
37	NPTX2	neuronal pentraxin II	11.0	Publications
38	CARTPT	CART prepropeptide	11.0	Publications
39	RPL10	ribosomal protein L10	11.0	Publications
40	NFIL3	nuclear factor, interleukin 3 regulated	11.0	Publications
41	DAOA	D-amino acid oxidase activator	11.0	Publications
42	ZNF711	zinc finger protein 711	11.0	Publications
43	AGRP	agouti related protein homolog (mouse)	11.0	Publications
44	NR2E1	nuclear receptor subfamily 2, group E, member 1	11.0	Publications
45	ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c	11.0	Publications
46	PITX3	paired-like homeodomain 3	11.0	Publications
47	SLC30A4	solute carrier family 30 (zinc transporter), member 4	11.0	Publications
48	NDN	necdin homolog (mouse)	11.0	Publications
49	SLC6A8	solute carrier family 6 (neurotransmitter transporter, creatine), member 8	11.0	Publications
50	INPP1	inositol polyphosphate-1-phosphatase	11.0	Publications

Pathways related to autism spectrum disorder according to GeneDecks:

(show all 28)

id	Pathway	Score	Top Affiliating Genes
1	Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q10	11.2	OPRL1, NPY, NPY1R, NPY2R, NPY5R, GRPR
2	Class A/1 (Rhodopsin-like receptors)38	11.1	OPRK1, OPRL1, NPY, NPY1R, NPY2R, NPY5R
3	G alpha (q) signalling events38	10.9	GRPR, OXTR, OXT, HCRTR2, HCRTR1, HCRT
4	Sympathetic Nerve Pathway (Neuroeffector Junction)34	10.8	NPY2R, SLC6A2, ADRA1B, ADRA2A, NPY1R, NPY
5	Tryptophan metabolism20	10.8	AANAT, DDC, TPH2, MAOB, MAOA, ASMT
6	Phenylalanine metabolism20	10.8	DDC, ALDH3A1, MAOB, MAOA, MIF
7	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	10.7	ADCY1, SLC6A4, DDC, TPH2, HTR2A, HTR1E
8	Tyrosine metabolism p.1 (dopamine)41	10.7	MAOB, ALDH3A1, DDC, COMT, DBH, MAOA
9	Tyrosine metabolism p.1 (dopamine)10	10.7	DBH, COMT, DDC, ALDH3A1, MAOB, MAOA
10	Tyrosine metabolism20	10.7	DBH, COMT, DDC, ALDH3A1, MAOB, MAOA
11	Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics34	10.7	SNAP25, PPP1R1B, DDC, DRD4, DRD3, DRD2
12	Amine ligand-binding receptors38	10.7	ADRA2A, ADRA1B, DRD5, DRD4, DRD3, DRD2
13	Circadian Clock in Mammals36	10.6	PER2, PER1, RORA, CSNK1E
14	GABA signaling in brain10	10.6	GABRA5, GABRB3, GABRG3, GAD2, GAD1, GABRA3
15	Calcium signaling pathway20	10.3	NOS1, NOS2, OXTR, PRKCB, ADCY1, ADORA2A
16	Dopamine-DARPP32 Feedback onto cAMP Pathway36	10.2	PPP1R3F, PPP1R1B, NOS1, CSNK1E, DRD5, DRD4
17	CDK5 Pathway36	10.1	ADCY1, PPP1R1B, PPP1R3F, DRD5, DRD4, DRD3
18	Neuroactive ligand-receptor interaction20	10.0	GRPR, OPRD1, PRL, OXTR, HCRTR2, HCRTR1
19	Small cell lung cancer20	10.0	PTGS2, PTEN, APAF1, LAMB1, BCL2, PIK3CG
20	Glutamic acid signaling10	9.9	GAD2, GAD1, SLC1A1, GRM8, GRIN2A, GRIK2
21	Adipocytokines & Insulin Signaling37	9.9	PRKCB, FOXO1, LEP, RETN, PIK3CG
22	Pathogenesis of ALS36	9.9	SLC1A1, CASP9, CASP3, GRIN2A, BCL2
23	p53 signaling pathway20	9.8	TSC2, PTEN, CASP9, CASP3, IGF1, IGFBP3
24	Neuroscience3	9.7	SNAP25, NOS1, GFAP, SYNGAP1, DBH, GAD1
25	Adipocytokine signaling pathway20	9.7	NPY, POMC, AGRP, ACSL4, TNF, LEPR
26	Presenilin-Mediated Signaling36	9.5	WNT2, DOCK3, CACNA1H, CASP9, CASP3, APC
27	Amyotrophic lateral sclerosis (ALS)20	9.5	NOS1, TNF, CASP9, CASP3, APAF1, GRIN2A
28	Pathways in cancer20	9.4	PRKCB, NOS2, PTEN, CASP9, CASP3, MET

Compounds related to autism spectrum disorder according to GeneDecks:

(show top 50)    (show all 383)

id	Compound	Score	Top Affiliating Genes
1	glucose32	10.8	PARK2, SCT, MTNR1B, LAMB1, AVP, CD38
2	haloperidol32 34 9 9	13.6	BDNF, MC4R, MCHR1, MAOB, HTR2A, DRD1
3	cyclic amp32 18	11.6	CNR1, CNR2, BDNF, SCT, ASMT, IL1RAPL2
4	bromocriptine32 9 9	12.3	HTR2A, HTR2C, DRD3, DRD5, DDC, PRL
5	mhpg32	10.3	BDNF, MAOA, MAOB, DRD4, DDC, COMT
6	methamphetamine32 9 9	12.2	BDNF, MAOA, MAOB, DRD1, DRD2, DRD3
7	methylphenidate32 9 9	12.2	MAOA, MAOB, DRD1, DRD2, DRD4, DRD5
8	maoa32	10.1	BDNF, MAOA, MAOB, HTR1B, HTR2A, HTR2C
9	apomorphine32 9 9	12.1	CNR1, MAOB, HTR1B, HTR2A, HTR2C, DRD1
10	ziprasidone32 9 9	12.0	CHRM5, HTR1B, HTR1E, HTR2A, HTR2C, DRD1
11	forskolin32 42 9 9	13.0	RETN, CNR2, BDNF, SCT, MUC1, IL1RAPL2
12	opiate32	10.0	MC4R, CCK, GHRL, DRD1, DRD2, DRD3
13	pramipexole32 9 9	12.0	BDNF, HTR1B, HTR2A, HTR2C, DRD1, DRD2
14	pergolide32 9 9	11.9	HTR1B, HTR2A, HTR2C, DRD1, DRD2, DRD3
15	catecholamine32	9.8	PARK2, BDNF, SCG5, SCT, AVP, MIF
16	aripiprazole32 34 9 18 9	13.8	CHRM5, HTR1B, HTR1E, HTR2A, HTR2C, DRD1
17	olanzapine32 34 9 18 9	13.7	BDNF, LEP, LEPR, CHRM5, HTR1B, HTR1E
18	histamine32 18	10.6	CNR1, BDNF, SCG5, SCT, IL1RAPL2, IL1RN
19	risperidone32 34 9 18 9	13.6	BDNF, SCT, LEP, HTR2A, HTR2C, GHRL
20	6-hydroxydopamine32	9.6	PARK2, BDNF, MAOA, MAOB, CASP3, DRD1
21	cabergoline32 9 9	11.5	IGFBP3, IGF1, HTR1B, HTR2A, HTR2C, DRD1
22	gnrh32	9.5	LEP, LEPR, AR, MC3R, IGFBP3, IGF1
23	mptp32	9.5	PARK2, BDNF, BCL2, CHRNA7, APAF1, MAOA
24	arginine32	9.4	CNR1, CNR2, SCG5, SCT, LEP, LEPR
25	cocaine32 9 9	11.4	CNR1, BDNF, LEP, LEPR, AR, MC3R
26	clozapine32 34 9 9	12.4	LEP, CHRNA7, CHRM5, HTR1E, HTR2A, HTR2C
27	acetylcholine32 9 18 9	12.4	CNR1, BDNF, SCT, LEP, CHRNA7, CHRNA4
28	nitric oxide32 9 18 9	12.4	RETN, PARK2, MUC1, AVP, MIF, MET
29	dopamine32 9 18 9	12.4	PARK2, BDNF, SCT, LEPR, CHRNA7, CHRM5
30	acth32	9.3	BDNF, SCG5, SCT, LEP, LEPR, MUC1
31	cysteine32	9.3	SCG5, SCT, LEPR, CHRNA7, MUC1, UBE3A
32	5-hydroxytryptamine32	9.3	CNR1, CHRNA7, ASMT, IL1RAPL2, MAOA, MAOB
33	naltrexone32 34 9 9	12.3	SCT, IGFBP3, IGF1, PNOC, PRL, OPRD1
34	morphine32 9 9	11.1	CNR1, MIF, IL1RAPL2, IL1RN, CCK, DRD1
35	corticosterone32 18	10.0	CNR1, BDNF, LEP, LEPR, MIF, IL1RAPL2
36	adenylate32	9.0	PIK3CG, CNR1, CNR2, BDNF, SCT, AR
37	epinephrine32 9 18 9	12.0	BDNF, SCT, LEP, IL1RAPL2, IL1RN, APC
38	lipid32	8.9	PIK3CG, RELN, RETN, CNR1, CNR2, RASGRP1
39	gaba32 42	9.7	RELN, CNR1, BDNF, SCT, LEP, CHRNA7
40	phosphatidylinositol32	8.7	PIK3CG, RELN, RETN, BDNF, BCL2, LEP
41	testosterone32 9 18 9	11.6	PARK2, BDNF, SCG5, SCT, MUC1, MTHFR
42	glutamate32	8.5	CNR1, CNR2, SCG5, LEP, LEPR, MTHFR
43	nmda32 42	8.9	RELN, CNR1, PARK2, BDNF, SCG5, LEP
44	tyrosine32	7.8	PIK3CG, NDN, RELN, RETN, CNR2, SEZ6L2
45	dexamethasone32 42 34 9 9	11.4	RETN, BCL2, SCG5, LEP, LEPR, MUC1
46	retinoic acid32 42 18	9.4	PIK3CG, NDN, BDNF, BCL2, SCT, MUC1
47	estrogen32	6.3	PIK3CG, RETN, PARK2, BDNF, BCL2, LEP
48	vegf32	5.9	PIK3CG, RETN, PARK2, BDNF, BCL2, LEP
49	calcium32 9 18 9	INF	RELN, RETN, CNR1, PCDH19, RASGRP1, PARK2
50	alanine32	INF	RETN, CNR1, PARK2, SCG5, LEPR, CHRNA7

Cellular components related to autism spectrum disorder according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	cytoplasm	GO:005737	INF	SHANK2, SHANK3, ACSL4, HES1, GFAP, TSC1
2	secretory granule	GO:030141	10.6	POMC, DBH, OXT, HCRT, GHRL, CARTPT
3	axonal growth cone	GO:044295	10.4	SNAP25, NRXN1, APC, COBL
4	terminal button	GO:043195	10.2	OPHN1, DBH, OXT, DRD4, CCK, GRIN2A
5	synapse	GO:045202	10.1	NLGN3, NOS1, SNAP25, NRXN1, NRCAM, CADM1
6	postsynaptic density	GO:014069	10.1	ADORA2A, SHANK3, SHANK2, NLGN4X, DISC1, DLGAP2
7	neuron projection	GO:043005	10.0	SHANK3, SHANK2, SNAP25, NRCAM, PTGS2, PTEN
8	presynaptic membrane	GO:042734	10.0	GAD2, ADORA2A, NRXN1, CADPS2, GRM8, GRIN2A
9	cell junction	GO:030054	9.9	SHANK2, SHANK3, HCRT, OPHN1, ADA, GABRA3
10	neuronal cell body	GO:043025	9.9	SNAP25, SHANK2, ACSL4, DBH, SLC6A3, ADORA2A
11	perikaryon	GO:043204	9.7	DRD2, CCK, GRIK2, CNTNAP2, CNR2, NDN
12	integral to plasma membrane	GO:005887	9.7	CNR1, CNR2, CHRM5, MUC1, MTNR1A, MTNR1B
13	axon	GO:030424	9.6	DRD2, DDC, LRRTM1, NPY1R, SLC6A3, SLC6A1
14	membrane	GO:016020	9.5	TSC1, TSC2, TSPAN12, DBH, SLC6A2, SLC1A1
15	dendrite	GO:030425	9.5	GABRA5, DBH, NLGN4X, DRD2, CCK, IL1RAPL1
16	postsynaptic membrane	GO:045211	9.4	NLGN4X, SHANK2, SHANK3, OPRD1, ADORA2A, GABRA3
17	cytosol	GO:005829	8.7	TSC1, GFAP, COMT, NLRP3, RPS6KA6, RPL10
18	plasma membrane	GO:005886	INF	NPY5R, GRPR, GAD2, GABRG3, SLC6A2, SLC6A3

Biological processes related to autism spectrum disorder according to GeneDecks:

(show top 50)    (show all 89)

id	Name	GO ID	Score	Top Affiliating Genes
1	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	GO:007187	11.1	CNR2, MTNR1A, MTNR1B, NPY1R, MC3R, HTR1B
2	G-protein coupled receptor signaling pathway	GO:007186	11.0	DRD3, HTR1E, PIK3CG, AVPR1A, ADRA1B, NPY5R
3	social behavior	GO:035176	11.0	NLGN4X, GRPR, SLC6A4, DBH, OXTR, OXT
4	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway	GO:007193	11.0	OPRL1, OPRK1, NPY2R, OPRD1, ADCY1, MCHR1
5	maternal behavior	GO:042711	10.9	AVP, AVPR1A, PTEN, OXT, OXTR, DBH
6	neuropeptide signaling pathway	GO:007218	10.9	HCRTR2, SCG5, CARTPT, PNOC, HCRT, HCRTR1
7	positive regulation of synapse assembly	GO:051965	10.8	OXT, NLGN3, OXTR, GHRL, MECP2, BDNF
8	visual learning	GO:008542	10.8	DBH, DRD5, DRD2, DRD1, GRIN2A, MECP2
9	locomotory behavior	GO:007626	10.8	CHRNA4, DRD2, DRD3, PTEN, DBH, NPY1R
10	feeding behavior	GO:007631	10.8	HTR2C, PYY, HCRTR1, AGRP, NPY, NPY1R
11	synaptic transmission, dopaminergic	GO:001963	10.8	DRD4, ADORA2A, DRD1, DRD2, DRD3, DRD5
12	regulation of inhibitory postsynaptic membrane potential	GO:060080	10.8	ADORA2A, GRIK2, DRD4, NLGN3, CHRNA4
13	response to amphetamine	GO:001975	10.7	OXT, DBH, CNR2, ADRA1B, PPP1R1B, DRD5
14	positive regulation of synaptic transmission, glutamatergic	GO:051968	10.7	ADORA2A, OXTR, RELN, NLGN3, SHANK3, NRXN1
15	sensory perception of pain	GO:019233	10.7	NPY1R, HTR2A, GRIN2A, MECP2, CHRNA4, CNR2
16	indolalkylamine biosynthetic process	GO:046219	10.7	DDC, AANAT, TPH2, ASMT
17	circadian rhythm	GO:007623	10.7	AANAT, PER1, LEP, MTNR1A, TPH2, DDC
18	behavioral response to cocaine	GO:048148	10.7	DRD4, ADRA1B, DRD3, DRD2, DRD1
19	eating behavior	GO:042755	10.7	OXT, LEP, HCRT, DRD1, CCK, OXTR
20	positive regulation of excitatory postsynaptic membrane potential	GO:2000463	10.7	SHANK3, NLGN3, NRXN1, PTEN, RELN
21	grooming behavior	GO:007625	10.6	DRD2, DRD1, AVPR1A, OXT, AVP
22	dopamine catabolic process	GO:042420	10.6	MAOA, DBH, SLC6A3, COMT
23	adult feeding behavior	GO:008343	10.6	AGRP, GHSR, NPY, GHRL, LEP, CARTPT
24	regulation of dopamine secretion	GO:014059	10.6	CHRNA4, HTR2A, HTR1B, DRD3, DRD2
25	fear response	GO:042596	10.6	DBH, DRD4, BDNF, ADRA2A
26	sleep	GO:030431	10.6	GRIN2A, OXTR, OXT, SNAP25, HTR2A
27	positive regulation of vasoconstriction	GO:045907	10.6	NPY1R, DBH, PTGS2, HTR2A, AVPR1A, AVP
28	prepulse inhibition	GO:060134	10.6	SLC6A3, DRD2, ADORA2A, DRD1, DRD3, PTEN
29	response to cocaine	GO:042220	10.6	DRD3, CNR1, SLC6A1, SLC6A3, OXTR, OXT
30	neurotransmitter biosynthetic process	GO:042136	10.5	MAOA, NOS1, SLC6A3, GAD1, GAD2, COMT
31	axonogenesis	GO:007409	10.5	ADCY1, CNTN4, APC, CCK, DRD2, NRCAM
32	regulation of long-term neuronal synaptic plasticity	GO:048169	10.5	DRD2, DRD1, GRIK2, CAMK2B, DRD5, SYNGAP1
33	behavior	GO:007610	10.5	CNR1, CNR2, CNTNAP2, LRRTM1, MAOA, OPRK1
34	dendrite development	GO:016358	10.5	GHRL, BDNF, MECP2, MCF2, RELN, SYNGAP1
35	behavioral fear response	GO:001662	10.5	GRIK2, DRD4, DRD1, MECP2, CCK, BCL2
36	negative regulation of blood pressure	GO:045776	10.5	CNR1, DRD2, DRD3, DRD5, OXT, NPY
37	regulation of excitatory postsynaptic membrane potential	GO:060079	10.5	GHRL, ADORA2A, HCRT, GRIK2, MECP2, GRIN2A
38	sperm ejaculation	GO:042713	10.4	OXT, OXTR, SLC6A4, AVPR1A
39	dopamine metabolic process	GO:042417	10.4	DRD1, DRD4, DRD2, DRD3, GRIN2A
40	response to nicotine	GO:035094	10.4	AVP, DRD2, SLC6A3, CHRNA7, BCL2, CNR1
41	memory	GO:007613	10.3	PTGS2, CNR1, CHRNA7, GRIN2A, IL1RN, HTR2A
42	synaptic transmission	GO:007268	10.2	HTR1B, HTR1E, HTR2A, HTR2C, HTR3B, CAMK2B
43	vocalization behavior	GO:071625	10.2	NRXN1, CNTNAP2, NLGN4X, SHANK3
44	presynaptic membrane assembly	GO:097105	10.1	NLGN4X, IL1RAPL1, NLGN3, NRXN1, PTEN
45	regulation of insulin secretion	GO:050796	9.7	ADRA2A, LEP, MTNR1B, CARTPT, CNR1, SNAP25
46	response to hypoxia	GO:001666	9.5	ADSL, CHRNA7, CHRNA4, MECP2, TNF, DRD2
47	negative regulation of apoptotic process	GO:043066	9.2	CASP3, PIK3CG, TNF, PTEN, SYNGAP1, PSMD10
48	brain development	GO:007420	9.2	RELN, SHANK2, NDUFS4, GABRA5, DLX2, UBE3A
49	response to drug	GO:042493	9.0	BDNF, BCL2, ALDH3A1, GRIN2A, IL1RN, APC
50	positive regulation of cell proliferation	GO:008284	INF	HTR2A, AR, ALDH3A1, DRD3, PTEN, HES1

Molecular functions related to autism spectrum disorder according to GeneDecks:

(show all 14)

id	Name	GO ID	Score	Top Affiliating Genes
1	peptide hormone binding	GO:017046	10.8	OXTR, HCRTR2, GHSR, MC4R, MC3R, AVPR1A
2	neuropeptide hormone activity	GO:005184	10.7	NPY, AGRP, HCRT, PNOC, PYY, CCK
3	melatonin receptor activity	GO:008502	10.6	MTNR1A, MTNR1B, GPR50
4	serotonin binding	GO:051378	10.6	HTR2C, HTR2A, HTR1E, HTR1B, MAOA
5	serotonin receptor activity	GO:004993	10.6	HTR3B, HTR2C, HTR2A, HTR1E, HTR1B
6	dopamine receptor activity	GO:004952	10.6	DRD5, DRD4, DRD1
7	dopamine binding	GO:035240	10.5	SLC6A3, DRD5, DRD4, DRD3, DRD2, DRD1
8	drug binding	GO:008144	10.4	CNR1, SLC6A3, DRD5, DRD4, DRD3, DRD2
9	peptide YY receptor activity	GO:001601	10.3	NPY1R, NPY2R, NPY5R
10	dopamine receptor activity, coupled via Gi/Go	GO:001591	10.3	DRD4, DRD3, DRD2
11	ionotropic glutamate receptor binding	GO:035255	10.1	OPHN1, SHANK3, SHANK2, DRD2
12	hormone activity	GO:005179	9.6	POMC, PRL, PYY, IGF1, CCK, LEP
13	receptor binding	GO:005102	9.1	SLC6A3, NPY, POMC, AGRP, NOS2, NRXN1
14	protein binding	GO:005515	INF	SNAP25, NOS1, NOS2, NOSTRIN, RPP25, NLGN3