MCID: ATS001
MIFTS: 72

Autistic Disorder malady

Neuronal diseases category

Summaries for Autistic Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Autism is a disorder that is usually diagnosed in early childhood. the main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. children with autism might have problems talking with you, or they might not look you in the eye when you talk to them. they may spend a lot of time putting things in order before they can pay attention, or they may say the same sentence again and again to calm themselves down. they often seem to be in their "own world." because people with autism can have very different features or symptoms, health care providers think of autism as a "spectrum" disorder. asperger syndrome is a milder version of the disorder. the cause of autism is not known. autism lasts throughout a person's lifetime. there is no cure, but treatment can help. treatments include behavior and communication therapies and medicines to control symptoms. starting treatment as early as possible is important. nih: national institute of child health and human development

MalaCards: Autistic Disorder, also known as autism, is related to asperger syndrome and pervasive developmental disorder. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Circadian entrainment and Neural Crest Differentiation. The drugs fenfluramine and risperidone and the compounds mpdt and yohimbine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

NINDS:43 Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).

Wikipedia:63 Autism is a disorder of neural development characterized by impaired social interaction and verbal and... more...

Description from OMIM:46 613436, 300496, 608636, 300830, 613410 209850, 300495, 300425, 612100, 611913 more

Aliases & Classifications for Autistic Disorder

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Sources:
8Disease Ontology, 20GeneTests, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 22GTR, 43NINDS, 33MedlinePlus, 44Novoseek, 56SNOMED-CT, 46OMIM, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autistic disorder 8 20 10 30 60
autism 8 20 22 43 33
autistic disorder of childhood onset 8 22
infantile psychosis 8 60
kanner's syndrome 8
infantile autism 8
childhood autism 8
autistic 44


Related Diseases for Autistic Disorder

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Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Autistic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 328)
idRelated DiseaseScoreTop Affiliating Genes
1asperger syndrome31.2NLGN3, NLGN4Y
2pervasive developmental disorder30.7SCT
3schizophrenia30.3HTR7, SCT
4intellectual disability30.1ARX, UBE3A
5rett syndrome29.9DLX5, UBE3A
6fragile x syndrome10.6
7developmental disabilities10.6
8adult syndrome10.4
9attention deficit hyperactivity disorder10.4
10neuronitis10.3
11angelman syndrome10.3
12cerebral palsy10.2
13autism susceptibility 1610.2
14autism susceptibility 1510.2
15autism susceptibility 1710.2
16autism 1810.2
17autism susceptibility, x-linked 210.2
18autism susceptibility, x-linked 110.2
19autism susceptibility, x-linked 310.2
20autism x-linked 510.2
21alexithymia10.2
22conduct disorder10.2
23echolalia10.2
24epsilon-trimethyllysine hydroxylase deficiency10.2
25obsessive-compulsive disorder10.2
26anxiety disorder10.2
27bipolar disorder10.2
28macrocephaly/autism syndrome10.1
29smith-lemli-opitz syndrome10.1
30neurofibromatosis10.1
31prader-willi syndrome10.1
32brain disease10.1
33charge syndrome10.1
34asperger syndrome susceptibility, x-linked 210.1
35asperger syndrome susceptibility, x-linked 110.1
36mental retardation with language impairment and autistic features10.1
37rubella10.1
38cerebritis10.1
39autism spectrum disorder10.1
40personality disorder10.1
41speech disorder10.1
42borna disease10.1
43lyme disease10.1
44mutism10.1
45fetal alcohol spectrum disorder10.1
46cohen syndrome10.0
47bruxism10.0
48x-linked ichthyosis10.0
49cornelia de lange syndrome10.0
50bipolar i disorder10.0

Graphical network of the top 20 diseases related to Autistic Disorder:



Diseases related to autistic disorder

Clinical Features for Autistic Disorder

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Sources:
46OMIM
See all sources

Clinical features from OMIM:

613436,300496,608636,300830,613410,209850,300495,300425,612100,611913

Drugs & Therapeutics for Autistic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autistic Disorder

Drug clinical trials:

Search ClinicalTrials for Autistic Disorder

Search NIH Clinical Center for Autistic Disorder

Search CenterWatch for Autistic Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autistic Disorder cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Autistic Disorder:
NU211-01/NC215-01, human umbilical cord mesenchymal stem cells for patients with autism
Embryonic/Adult Cultured Cells Related to Autistic Disorder:
Umbilical cord-derived mesenchymal stem cells
Umbilical cord blood-derived mononuclear cells

Genetic Tests for Autistic Disorder

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Autistic Disorder:

id Genetic test Affiliating Genes
1 Autism Multi-Gene Panels20
2 Autistic Disorder20 SNRPN
3 Autistic Disorder of Childhood Onset22
4 Autism22

Anatomical Context for Autistic Disorder

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Autistic Disorder:

32
Brain, Eye, Testes, Cortex, Monocytes, Amygdala

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autistic Disorder:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autistic Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Autistic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5PER1, NLGN2, NLGN3, UBE3A, MBD1, HTR7
2MP:000363110.5HTR7, MBD1, UBE3A, NLGN3, NLGN2, SCT
3MP:000301210.4NLGN3, UBE3A, GABRA5, OMG, HOXB1, HOXA1
4MP:001076810.4ARX, HTR7, UBE3A, NLGN3, NLGN2, SSBP1
5MP:000287310.4NLGN3, HTR5A, ARX, OMG, HOXB1, HOXA1
6MP:000537610.4HTR7, SCT, ARX, OMG, HOXA1, WNT2
7MP:000538810.3NLGN2, NLGN3, HOXB1, HOXA1, DLX5, WNT2
8MP:000537810.0NLGN2, NLGN3, UBE3A, ARX, HOXB1, DLX5

Publications for Autistic Disorder

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Sources:
50PubMed
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Articles related to Autistic Disorder:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
HPA and SAM axis responses as correlates of self- vs parental ratings of anxiety in boys with an Autistic Disorder. (24412722)
2014
2
A randomised group comparison controlled trial of 'preschoolers with autism': A parent education and skills training intervention for young children with autistic disorder. (22987897)
2014
3
Managing disruptive and compulsive behaviors in adult with autistic disorder with gabapentin. (23422383)
2013
4
Effectiveness of methylcobalamin and folinic Acid treatment on adaptive behavior in children with autistic disorder is related to glutathione redox status. (24224089)
2013
5
Detection of copy-number variation in AUTS2 gene by targeted exonic array CGH in patients with developmental delay and autistic spectrum disorders. (22872102)
2013
6
Case report: 16-Year-old male with autistic disorder with preoccupation with female feet. (21818675)
2012
7
Abnormal patterns of cerebral lateralisation as revealed by the Universal Chimeric Faces Task in individuals with autistic disorder. (22690895)
2012
8
Aripiprazole in the treatment of irritability associated with autistic disorder in paediatric patients: profile report. (21870890)
2011
9
The autistic phenotype in Down syndrome: differences in adaptive behaviour versus Down syndrome alone and autistic disorder alone. (22152436)
2011
10
Greater disruption to control of voluntary saccades in autistic disorder than Asperger's disorder: evidence for greater cerebellar involvement in autism? (21072692)
2011
11
Deficits in temporal processing associated with autistic disorder. (21472033)
2011
12
Congenital rubella syndrome with autistic disorder. (20171592)
2010
13
Early-onset acquired epileptic aphasia (Landau-Kleffner syndrome, LKS) and regressive autistic disorders with epileptic EEG abnormalities: the continuing debate. (20637551)
2010
14
MRI findings in 77 children with non-syndromic autistic disorder. (19204795)
2009
15
Case report: autistic disorder in Kabuki syndrome. (17721696)
2008
16
Study of the relationship between tuberous sclerosis complex and autistic disorder. (16901420)
2006
17
A prospective, open-label trial of galantamine in autistic disorder. (17069550)
2006
18
Efficacy and safety of naltrexone use in pediatric patients with autistic disorder. (16735648)
2006
19
Autistic-like findings associated with a urea cycle disorder in a 4-year-old girl. (15798789)
2005
20
The overt aggression scale for rating aggression in outpatient youth with autistic disorder: preliminary findings. (15746480)
2005
21
Characteristics of fetal anticonvulsant syndrome associated autistic disorder. (16108456)
2005
22
Accentuated Virchow-Robin spaces in the centrum semiovale in children with autistic disorder. (15091132)
2004
23
Pilot study of a moderate dose multivitamin/mineral supplement for children with autistic spectrum disorder. (15673999)
2004
24
Annotation: The similarities and differences between autistic disorder and Asperger's disorder: a review of the empirical evidence. (15055363)
2004
25
Behavioral training for pill-swallowing difficulties in young children with autistic disorder. (15662153)
2004
26
Validity of childhood disintegrative disorder apart from autistic disorder with speech loss. (15365892)
2004
27
Brief report: autistic disorder in three children with cytomegalovirus infection. (15628611)
2004
28
Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network. (15162933)
2004
29
External validity of childhood disintegrative disorder in comparison with autistic disorder. (15264502)
2004
30
Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. (12567325)
2003
31
Validity of DQ as an estimate of IQ in children with autistic disorder. (12667172)
2003
32
Acquired epileptiform aphasia: a dimensional view of Landau-Kleffner syndrome and the relation to regressive autistic spectrum disorders. (12759834)
2002
33
Re: Clomipramine vs. Haloperidol in the treatment of autistic disorder: a double-blind, placebo, crossover study. (12352279)
2002
34
Double-blind, placebo-controlled study of amantadine hydrochloride in the treatment of children with autistic disorder. (11392343)
2001
35
Hand preferences in sign-learning students with autistic disorder. (15513175)
2001
36
The functional neuroanatomy of social behaviour: changes in cerebral blood flow when people with autistic disorder process facial expressions. (11050021)
2000
37
A Double-Blind, Placebo-Controlled Trial of Secretin for the Treatment of Autistic Disorder. (11104404)
1999
38
On the biological treatment of autistic disorder. (10416959)
1999
39
Movements in autistic disorder. (10499825)
1999
40
A patient with autistic disorder and a 20/22 chromosomal translocation. (9698063)
1998
41
A double-blind, placebo-controlled study of risperidone in adults with autistic disorder and other pervasive developmental disorders. (9672054)
1998
42
Visual agnosia with bilateral temporo-occipital brain lesions in a child with autistic disorder: a case study. (9352734)
1997
43
Effects of tryptophan depletion in drug-free adults with autistic disorder. (8911222)
1996
44
The prevalence of autistic disorder among children with a learning disability. (7994515)
1994
45
Contextual probability evaluation in autistic, receptive developmental language disorder, and control children: event-related brain potential evidence. (8463201)
1993
46
A double-blind comparison of clomipramine, desipramine, and placebo in the treatment of autistic disorder. (8498878)
1993
47
A review of the DSM-III-R criteria for autistic disorder. (1483974)
1992
48
Differential response of seven subjects with autistic disorder to clomipramine and desipramine. (1536276)
1992
49
Brief report: a girl aged two years and seven months with autistic disorder videotaped from birth. (1592762)
1992
50
The use of signal detection theory to assess DSM-III-R criteria for autistic disorder. (2768150)
1989

Genetic Variations for Autistic Disorder

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Expression for genes affiliated with Autistic Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autistic Disorder

Search GEO for disease gene expression data for Autistic Disorder.

Pathways for genes affiliated with Autistic Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 52R&D Systems
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Compounds for genes affiliated with Autistic Disorder

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Sources:
28IUPHAR, 44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1mpdt2810.7HTR7, HTR5A
2yohimbine44 28 2 1113.7HTR7, HTR5A, TAS2R1
3[3h]5-ct2810.7HTR7, HTR5A
4emdt2810.7HTR5A, HTR7
5gaba4410.7DLX5, ARX, GABRA5, SCT, UBE3A
68-oh-dpat2810.7HTR5A, HTR7
75-ct2810.7HTR7, HTR5A
8methiothepin44 2811.6HTR5A, HTR7
9ritanserin28 4411.6HTR5A, HTR7
105-ht2810.6HTR5A, HTR7
11metergoline44 2811.5HTR7, HTR5A
12methysergide44 28 1112.5HTR5A, HTR7
13sumatriptan44 28 59 49 11 2415.5HTR5A, HTR7
14ketanserin28 4411.4HTR5A, HTR7
15benzodiazepine4410.1PER1, UBE3A

GO Terms for genes affiliated with Autistic Disorder

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Sources:
16Gene Ontology
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Cellular components related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4GABRA5, NLGN3, NLGN2, NLGN4Y
2integral to plasma membraneGO:00588710.3GABRA5, HTR5A, HTR7, NLGN3, NLGN2, NLGN4Y
3synapseGO:04520210.1NLGN4Y, NLGN2, NLGN3

Biological processes related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1rhombomere 4 developmentGO:02157010.7HOXA1, HOXB1
2facial nucleus developmentGO:02175410.7HOXB1, HOXA1
3rhombomere 5 developmentGO:02157110.7HOXB1, HOXA1
4facial nerve structural organizationGO:02161210.7HOXB1, HOXA1
5synapse assemblyGO:00741610.7NLGN3, NLGN2, NLGN4Y
6postsynaptic membrane assemblyGO:09710410.7NLGN3, NLGN2
7anatomical structure formation involved in morphogenesisGO:04864610.7DLX5, HOXB1
8presynaptic membrane assemblyGO:09710510.6NLGN3, NLGN2
9serotonin receptor signaling pathwayGO:00721010.6HTR7, HTR5A
10positive regulation of excitatory postsynaptic membrane potentialGO:200046310.6NLGN3, NLGN2
11neuron cell-cell adhesionGO:00715810.6NLGN3, NLGN2
12regulation of respiratory gaseous exchange by neurological system processGO:00208710.5NLGN2, NLGN3
13cochlea developmentGO:09010210.4HOXA1, GABRA5
14positive regulation of transcription from RNA polymerase II promoterGO:04594410.4EN2, WNT2, HOXA1, HOXB1, UBE3A
15positive regulation of synaptic transmission, glutamatergicGO:05196810.3NLGN2, NLGN3
16positive regulation of synapse assemblyGO:05196510.1NLGN3, NLGN2

Molecular functions related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NLGN3, NLGN2
2neurexin family protein bindingGO:04204310.4NLGN3, NLGN2, NLGN4Y
3receptor activityGO:00487210.3NLGN4Y, NLGN2, NLGN3, GABRA5
4serotonin receptor activityGO:00499310.2HTR5A, HTR7

Products for genes affiliated with Autistic Disorder

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  • Antibodies
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Sources for Autistic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet