MCID: ATS001
MIFTS: 72

Autistic Disorder malady

Neuronal diseases category

Summaries for Autistic Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Autism is a disorder that is usually diagnosed in early childhood. the main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. children with autism might have problems talking with you, or they might not look you in the eye when you talk to them. they may spend a lot of time putting things in order before they can pay attention, or they may say the same sentence again and again to calm themselves down. they often seem to be in their "own world." because people with autism can have very different features or symptoms, health care providers think of autism as a "spectrum" disorder. asperger syndrome is a milder version of the disorder. the cause of autism is not known. autism lasts throughout a person's lifetime. there is no cure, but treatment can help. treatments include behavior and communication therapies and medicines to control symptoms. starting treatment as early as possible is important. nih: national institute of child health and human development

MalaCards: Autistic Disorder, also known as autism, is related to asperger syndrome and pervasive developmental disorder. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Circadian entrainment and Neural Crest Differentiation. The drugs fenfluramine and risperidone and the compounds mpdt and yohimbine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

NINDS:43 Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).

Wikipedia:63 Autism is a disorder of neural development characterized by impaired social interaction and verbal and... more...

Description from OMIM:46 613436, 300496, 608636, 300830, 613410 209850, 300495, 300425, 612100, 611913 more

Aliases & Classifications for Autistic Disorder

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Sources:
8Disease Ontology, 20GeneTests, 10DISEASES, 30LifeMap Discovery™, 60UMLS, 22GTR, 43NINDS, 33MedlinePlus, 44Novoseek, 56SNOMED-CT, 46OMIM, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autistic disorder 8 20 10 30 60
autism 8 20 22 43 33
autistic disorder of childhood onset 8 22
infantile psychosis 8 60
kanner's syndrome 8
infantile autism 8
childhood autism 8
autistic 44


Related Diseases for Autistic Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Autistic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 328)
idRelated DiseaseScoreTop Affiliating Genes
1asperger syndrome31.2NLGN3, NLGN4Y
2pervasive developmental disorder30.7SCT
3schizophrenia30.3HTR7, SCT
4intellectual disability30.1ARX, UBE3A
5rett syndrome29.9DLX5, UBE3A
6fragile x syndrome10.6
7developmental disabilities10.6
8adult syndrome10.4
9attention deficit hyperactivity disorder10.4
10neuronitis10.3
11angelman syndrome10.3
12cerebral palsy10.2
13autism susceptibility 1610.2
14autism susceptibility 1510.2
15autism susceptibility 1710.2
16autism 1810.2
17autism susceptibility, x-linked 210.2
18autism susceptibility, x-linked 110.2
19autism susceptibility, x-linked 310.2
20autism x-linked 510.2
21alexithymia10.2
22conduct disorder10.2
23echolalia10.2
24epsilon-trimethyllysine hydroxylase deficiency10.2
25obsessive-compulsive disorder10.2
26anxiety disorder10.2
27bipolar disorder10.2
28macrocephaly/autism syndrome10.1
29smith-lemli-opitz syndrome10.1
30neurofibromatosis10.1
31prader-willi syndrome10.1
32brain disease10.1
33charge syndrome10.1
34asperger syndrome susceptibility, x-linked 210.1
35asperger syndrome susceptibility, x-linked 110.1
36mental retardation with language impairment and autistic features10.1
37rubella10.1
38cerebritis10.1
39autism spectrum disorder10.1
40personality disorder10.1
41speech disorder10.1
42borna disease10.1
43lyme disease10.1
44mutism10.1
45fetal alcohol spectrum disorder10.1
46cohen syndrome10.0
47bruxism10.0
48x-linked ichthyosis10.0
49cornelia de lange syndrome10.0
50bipolar i disorder10.0

Graphical network of the top 20 diseases related to Autistic Disorder:



Diseases related to autistic disorder

Clinical Features for Autistic Disorder

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Sources:
46OMIM
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Clinical features from OMIM:

613436,300496,608636,300830,613410,209850,300495,300425,612100,611913

Drugs & Therapeutics for Autistic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autistic Disorder

Drug clinical trials:

Search ClinicalTrials for Autistic Disorder

Search NIH Clinical Center for Autistic Disorder

Search CenterWatch for Autistic Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autistic Disorder cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Autistic Disorder:
NU211-01/NC215-01, human umbilical cord mesenchymal stem cells for patients with autism
Embryonic/Adult Cultured Cells Related to Autistic Disorder:
Umbilical cord-derived mesenchymal stem cells
Umbilical cord blood-derived mononuclear cells

Genetic Tests for Autistic Disorder

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Autistic Disorder:

id Genetic test Affiliating Genes
1 Autism Multi-Gene Panels20
2 Autistic Disorder20 SNRPN
3 Autistic Disorder of Childhood Onset22
4 Autism22

Anatomical Context for Autistic Disorder

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Autistic Disorder:

32
Brain, Eye, Testes, Cortex, Monocytes, Amygdala

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autistic Disorder:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autistic Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Autistic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5PER1, NLGN2, NLGN3, UBE3A, MBD1, HTR7
2MP:000363110.5HTR7, MBD1, UBE3A, NLGN3, NLGN2, SCT
3MP:000301210.4NLGN3, UBE3A, GABRA5, OMG, HOXB1, HOXA1
4MP:001076810.4ARX, HTR7, UBE3A, NLGN3, NLGN2, SSBP1
5MP:000287310.4NLGN3, HTR5A, ARX, OMG, HOXB1, HOXA1
6MP:000537610.4HTR7, SCT, ARX, OMG, HOXA1, WNT2
7MP:000538810.3NLGN2, NLGN3, HOXB1, HOXA1, DLX5, WNT2
8MP:000537810.0NLGN2, NLGN3, UBE3A, ARX, HOXB1, DLX5

Publications for Autistic Disorder

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Sources:
50PubMed
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Articles related to Autistic Disorder:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial. (23821414)
2013
2
Investigating mechanisms underlying neurodevelopmental phenotypes of autistic and intellectual disability disorders: a perspective. (24198768)
2013
3
Magnetic resonance spectroscopy study of the glutamatergic system in adolescent males with high-functioning autistic disorder: a pilot study at 4T. (22986449)
2013
4
Quality of life among parents of children with autistic disorder: A sample from the Arab world. (24316492)
2013
5
335.4 kb microduplication in chromosome band Xp11.2p11.3 associated with developmental delay, growth retardation, autistic disorder and dysmorphic features. (22634100)
2012
6
Measuring the effects of alexithymia on perception of emotional vocalizations in autistic spectrum disorder and typical development. (22475181)
2012
7
Oral health status of children with autistic disorder in Chennai. (22652209)
2012
8
Plasma cytokine levels in children with autistic disorder and unrelated siblings. (22197967)
2012
9
Postoperative cerebellar mutism and autistic spectrum disorder. (21052695)
2011
10
The relationship between race and challenging behaviours in infants and toddlers with autistic disorder and pervasive developmental disorder-not otherwise specified. (21732805)
2011
11
Increased serum levels of high mobility group box 1 protein in patients with autistic disorder. (20302902)
2010
12
A complex chromosome 7q rearrangement identified in a patient with mental retardation, anxiety disorder, and autistic features. (20082467)
2010
13
Association of autistic spectrum disorders with dystrophinopathies. (19818935)
2009
14
First preliminary results of an observation of Panax ginseng treatment in patients with autistic disorder. (22435515)
2009
15
St John's Wort treating patients with autistic disorder. (19274686)
2009
16
Dyadic and triadic behaviours in infancy as precursors to later social responsiveness in young children with autistic disorder. (19475503)
2009
17
Rightward hemispheric asymmetries in auditory language cortex in children with autistic disorder: an MRI investigation. (19816533)
2009
18
Sequencing and analyzing the t(1;7) reciprocal translocation breakpoints associated with a case of childhood-onset schizophrenia/autistic disorder. (17879154)
2008
19
The relationship between sensory processing patterns and behavioural responsiveness in autistic disorder: a pilot study. (17899349)
2008
20
Autistic disorder in 2 children with mitochondrial disorders. (17890412)
2007
21
Ziprasidone for maladaptive behavior and attention-deficit/hyperactivity disorder symptoms in autistic disorder. (17489724)
2007
22
Joint attention, language, social relating, and stereotypical behaviours in children with autistic disorder. (17942456)
2007
23
Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. (17346350)
2007
24
Assessing the early characteristics of autistic disorder using video analysis. (17031450)
2007
25
Associated medical disorders and disabilities in children with autistic disorder: a population-based study. (15070547)
2004
26
Leo Kanner: his years in Berlin, 1906-24. The roots of autistic disorder. (14518490)
2003
27
Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. (14639049)
2003
28
Face processing in adolescents with autistic disorder: the inversion and composite effects. (12907173)
2003
29
Genetic and neurodevelopmental influences in autistic disorder. (14574828)
2003
30
Possible association between congenital cytomegalovirus infection and autistic disorder. (12959425)
2003
31
Oxytocin infusion reduces repetitive behaviors in adults with autistic and Asperger's disorders. (12496956)
2003
32
Molecular genetics and animal models in autistic disorder. (11827743)
2002
33
Secretin treatment for autistic disorder: a critical analysis. (12126223)
2002
34
Genomic screen and follow-up analysis for autistic disorder. (11840513)
2002
35
Lamotrigine therapy for autistic disorder: a randomized, double-blind, placebo-controlled trial. (11450816)
2001
36
Chromosomal abnormalities in a clinic sample of individuals with autistic disorder. (11525418)
2001
37
Autistic disorder and schizophrenia: diagnostic overlaps. (11439750)
2001
38
Three probands with autistic disorder and isodicentric chromosome 15. (10898916)
2000
39
Childhood-onset schizophrenia/autistic disorder and t(1;7) reciprocal translocation: identification of a BAC contig spanning the translocation breakpoint at 7q21. (11121174)
2000
40
A double-blind, placebo-controlled, crossover pilot trial of low dose dimethylglycine in patients with autistic disorder. (10425581)
1999
41
A comparison of obstetric and neonatal complications between children with autistic disorder and their siblings. (9089463)
1997
42
High-dose pyridoxine and magnesium administration in children with autistic disorder: an absence of salutary effects in a double-blind, placebo-controlled study. (9261669)
1997
43
The changing prevalence of autistic disorder in a Welsh health district. (9112962)
1997
44
A case-control study of obstetric complications and later autistic disorder. (8863095)
1996
45
A case-controlled study of repetitive thoughts and behavior in adults with autistic disorder and obsessive-compulsive disorder. (7726318)
1995
46
Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. (8047619)
1994
47
Brief report: cases for an association between Tourette syndrome, autistic disorder, and schizophrenia-like disorder. (8331056)
1993
48
Fluoxetine treatment of children and adults with autistic disorder and mental retardation. (1644739)
1992
49
Autistic disorder in Sotos syndrome: a case report. (2347353)
1990
50
Parent-child dyadic gaze patterns in fragile X males and in non-fragile X males with autistic disorder. (2592468)
1989

Genetic Variations for Autistic Disorder

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Expression for genes affiliated with Autistic Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autistic Disorder

Search GEO for disease gene expression data for Autistic Disorder.

Pathways for genes affiliated with Autistic Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 52R&D Systems
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Compounds for genes affiliated with Autistic Disorder

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Sources:
28IUPHAR, 44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1mpdt2810.7HTR7, HTR5A
2yohimbine44 28 2 1113.7HTR7, HTR5A, TAS2R1
3[3h]5-ct2810.7HTR7, HTR5A
4emdt2810.7HTR5A, HTR7
5gaba4410.7DLX5, ARX, GABRA5, SCT, UBE3A
68-oh-dpat2810.7HTR5A, HTR7
75-ct2810.7HTR7, HTR5A
8methiothepin44 2811.6HTR5A, HTR7
9ritanserin28 4411.6HTR5A, HTR7
105-ht2810.6HTR5A, HTR7
11metergoline44 2811.5HTR7, HTR5A
12methysergide44 28 1112.5HTR5A, HTR7
13sumatriptan44 28 59 49 11 2415.5HTR5A, HTR7
14ketanserin28 4411.4HTR5A, HTR7
15benzodiazepine4410.1PER1, UBE3A

GO Terms for genes affiliated with Autistic Disorder

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Sources:
16Gene Ontology
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Cellular components related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4GABRA5, NLGN3, NLGN2, NLGN4Y
2integral to plasma membraneGO:00588710.3GABRA5, HTR5A, HTR7, NLGN3, NLGN2, NLGN4Y
3synapseGO:04520210.1NLGN4Y, NLGN2, NLGN3

Biological processes related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1rhombomere 4 developmentGO:02157010.7HOXA1, HOXB1
2facial nucleus developmentGO:02175410.7HOXB1, HOXA1
3rhombomere 5 developmentGO:02157110.7HOXB1, HOXA1
4facial nerve structural organizationGO:02161210.7HOXB1, HOXA1
5synapse assemblyGO:00741610.7NLGN3, NLGN2, NLGN4Y
6postsynaptic membrane assemblyGO:09710410.7NLGN3, NLGN2
7anatomical structure formation involved in morphogenesisGO:04864610.7DLX5, HOXB1
8presynaptic membrane assemblyGO:09710510.6NLGN3, NLGN2
9serotonin receptor signaling pathwayGO:00721010.6HTR7, HTR5A
10positive regulation of excitatory postsynaptic membrane potentialGO:200046310.6NLGN3, NLGN2
11neuron cell-cell adhesionGO:00715810.6NLGN3, NLGN2
12regulation of respiratory gaseous exchange by neurological system processGO:00208710.5NLGN2, NLGN3
13cochlea developmentGO:09010210.4HOXA1, GABRA5
14positive regulation of transcription from RNA polymerase II promoterGO:04594410.4EN2, WNT2, HOXA1, HOXB1, UBE3A
15positive regulation of synaptic transmission, glutamatergicGO:05196810.3NLGN2, NLGN3
16positive regulation of synapse assemblyGO:05196510.1NLGN3, NLGN2

Molecular functions related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NLGN3, NLGN2
2neurexin family protein bindingGO:04204310.4NLGN3, NLGN2, NLGN4Y
3receptor activityGO:00487210.3NLGN4Y, NLGN2, NLGN3, GABRA5
4serotonin receptor activityGO:00499310.2HTR5A, HTR7

Products for genes affiliated with Autistic Disorder

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Sources for Autistic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet