MCID: ATS001
MIFTS: 71

Autistic Disorder malady

Genetic diseases (common), Mental diseases, Fetal diseases categories
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Summaries for Autistic Disorder

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Disease Ontology:8 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

MalaCards based summary: Autistic Disorder, also known as autism, is related to asperger syndrome and fragile x syndrome. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. The drugs fenfluramine and risperidone and the compounds mpdt and [3h]5-ct have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex, and related mouse phenotypes are no phenotypic analysis and normal.

NINDS:43 Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).

Wikipedia:65 Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and... more...

Descriptions from OMIM:46 300495, 611913, 613410, 612100, 300496 613436, 209850, 300425, 608636, 300830 more

Aliases & Classifications for Autistic Disorder

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Autistic Disorder, Aliases & Descriptions:

Name: Autistic Disorder 30 8 20 10 62
Autism 8 20 22 43
Autistic Disorder of Childhood Onset 8 22 62
Infantile Psychosis 8 62
 
Kanner's Syndrome 8
Infantile Autism 8
Childhood Autism 8
Autistic 44


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Fetal diseases
Anatomical: Mental diseases


Related Diseases for Autistic Disorder

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Diseases related to Autistic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 372)
idRelated DiseaseScoreTop Affiliating Genes
1asperger syndrome10.9
2fragile x syndrome10.7
3blindness10.7
4developmental disabilities10.7
5pervasive developmental disorder10.5
6williams syndrome10.5
7mental retardation10.5
8attention deficit hyperactivity disorder10.4
9pervasive developmental disorder not otherwise specified10.4
10neuronitis10.4
11angelman syndrome10.3
12measles10.3
13mumps10.3
14schizophrenia10.3
15cerebral palsy10.3
16autism susceptibility 1610.3
17autism susceptibility 1510.3
18autism susceptibility 1710.3
19autism 1810.3
20autism susceptibility, x-linked 210.3
21autism susceptibility, x-linked 110.3
22autism susceptibility, x-linked 310.3
23autism x-linked 510.3
24mental retardation with language impairment and autistic features10.2
25bipolar disorder10.2
26alexithymia10.2
27echolalia10.2
28epsilon-trimethyllysine hydroxylase deficiency10.2
29prader-willi syndrome10.2
30neurofibromatosis10.2
31macrocephaly/autism syndrome10.2
32smith-lemli-opitz syndrome10.2
33charge syndrome10.2
34megalencephaly10.2
35asperger syndrome susceptibility, x-linked 210.2
36asperger syndrome susceptibility, x-linked 110.2
37obsessive-compulsive disorder10.1
38cerebritis10.1
39autism spectrum disorder10.1
40childhood-onset schizophrenia10.1
41cytomegalovirus infection10.1
42conduct disorder10.1
43borna disease10.1
44lyme disease10.1
45mutism10.1
46fetal alcohol spectrum disorder10.1
47endotheliitis10.1
48cohen syndrome10.1
49brain injury10.0
50x-linked ichthyosis10.0

Graphical network of the top 20 diseases related to Autistic Disorder:



Diseases related to autistic disorder

Symptoms for Autistic Disorder

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Clinical features from OMIM:

300495,611913,613410,612100,300496,613436,209850,300425,608636,300830

Drugs & Therapeutics for Autistic Disorder

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Drug clinical trials:

Search ClinicalTrials for Autistic Disorder

Search NIH Clinical Center for Autistic Disorder

Inferred drug relations via UMLS62/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autistic Disorder cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Autistic Disorder:
NU211-01/NC215-01, human umbilical cord mesenchymal stem cells for patients with autism
Embryonic/Adult Cultured Cells Related to Autistic Disorder:
Umbilical cord-derived mesenchymal stem cells
Umbilical cord blood-derived mononuclear cells

Genetic Tests for Autistic Disorder

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Genetic tests related to Autistic Disorder:

id Genetic test Affiliating Genes
1 Autism Multi-Gene Panels20
2 Autistic Disorder20 SNRPN
3 Autistic Disorder of Childhood Onset22
4 Autism22

Anatomical Context for Autistic Disorder

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MalaCards organs/tissues related to Autistic Disorder:

32
Brain, Testes, Cortex, Monocytes, Amygdala

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autistic Disorder:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autistic Disorder or affiliated genes

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MGI Mouse Phenotypes related to Autistic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.2EN2, OMG, HOXA1, HOXB1
2MP:00028737.9OMG, HOXA1, ARX, HOXB1, HTR5A
3MP:00053847.8HOXB1, HOXA1, MBD1, EN2, ARX
4MP:00053767.7HOXA1, ARX, EN2, SCT, OMG, HTR7
5MP:00036317.2ARX, EN2, MBD1, HOXA1, HTR7, SCT
6MP:00053866.9EN2, ARX, MBD1, HTR5A, HTR7, SCT

Publications for Autistic Disorder

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Articles related to Autistic Disorder:

(show top 50)    (show all 398)
idTitleAuthorsYear
1
Effects of risperidone on core symptoms of autistic disorder based on childhood autism rating scale: an open label study. (24701014)
2014
2
Risk of autistic disorder after exposure to general anaesthesia and surgery: A nationwide, retrospective matched cohort study. (25101714)
2014
3
Validation of the World Health Organization's Quality of Life Questionnaire with parents of children with autistic disorder. (24696377)
2014
4
Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial. (23821414)
2013
5
Psychosocial interventions for reducing vocal challenging behavior in persons with autistic disorder: a multilevel meta-analysis of single-case experiments. (24183495)
2013
6
Phosphatase and tensin homolog (PTEN) gene mutations and autism: literature review and a case report of a patient with Cowden syndrome, autistic disorder, and epilepsy. (21960672)
2012
7
Aripiprazole: in the treatment of irritability associated with autistic disorder in pediatric patients. (21500873)
2011
8
Autistic disorder and phospholipids: A review. (20970971)
2011
9
ASSESSMENT OF DISTRESS IN YOUNG CHILDREN: A COMPARISON OF AUTISTIC DISORDER, DEVELOPMENTAL DELAY, AND TYPICAL DEVELOPMENT. (21647245)
2011
10
Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. (19777562)
2010
11
Congenital rubella syndrome with autistic disorder. (20171592)
2010
12
Increased serum levels of high mobility group box 1 protein in patients with autistic disorder. (20302902)
2010
13
Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. (19681062)
2009
14
A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. (19797985)
2009
15
Family analysis of immunoglobulin classes and subclasses in children with autistic disorder. (20001993)
2009
16
Prediction of autistic disorder using neuro fuzzy system by applying ANN technique. (18706991)
2008
17
Ramelteon for insomnia in two youths with autistic disorder. (17069551)
2006
18
Risperidone for autistic disorder. (16216155)
2005
19
The overt aggression scale for rating aggression in outpatient youth with autistic disorder: preliminary findings. (15746480)
2005
20
Neonatal factors in infants with Autistic Disorder and typically developing infants. (16287701)
2005
21
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. (15652871)
2005
22
Intervention,treatmentand care in autistic disorder. Challenging case reports from northern Finland. (15776994)
2005
23
Characteristics of fetal anticonvulsant syndrome associated autistic disorder. (16108456)
2005
24
Teaching children with attention deficit hyperactivity disorder (ADHD) and autistic disorder (AD) how to swallow pills. (16015399)
2005
25
Deletion 2q37.3 and autism: molecular cytogenetic mapping of the candidate region for autistic disorder. (15517821)
2004
26
High blood monocyte counts and neopterin levels in children with autistic disorder. (12944347)
2003
27
Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. (12566166)
2003
28
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. (14627686)
2003
29
Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. (12567325)
2003
30
Smaller left hemisphere planum temporale in adults with autistic disorder. (12147315)
2002
31
Exploring the borderlands of autistic disorder and specific language impairment: a study using standardised diagnostic instruments. (12405479)
2002
32
Molecular genetics and animal models in autistic disorder. (11827743)
2002
33
Long-term treatment with clozapine in an adult with autistic disorder accompanied by aggressive behaviour. (11590976)
2001
34
Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. (12092907)
2001
35
Olanzapine versus haloperidol in children with autistic disorder: an open pilot study. (11501687)
2001
36
Three probands with autistic disorder and isodicentric chromosome 15. (10898916)
2000
37
Brief report: incidence of and risk factors for autistic disorder in neonatal intensive care unit survivors. (10382137)
1999
38
A Double-Blind, Placebo-Controlled Trial of Secretin for the Treatment of Autistic Disorder. (11104404)
1999
39
Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. (10490701)
1999
40
Gastrointestinal abnormalities in children with autistic disorder. (10547242)
1999
41
Mutation screening of the UBE3A/E6-AP gene in autistic disorder. (10089011)
1999
42
The savant syndrome and autistic disorder. (18311109)
1999
43
Sociosexual knowledge, experience, attitudes, and interests of individuals with autistic disorder and developmental delay. (9261666)
1997
44
Sertraline response in adults with mental retardation and autistic disorder. (8778118)
1996
45
Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. (8935216)
1996
46
Season of birth and autistic disorder in Israel. (7726324)
1995
47
Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT. (7790938)
1995
48
Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. (8047619)
1994
49
Brief report: cases for an association between Tourette syndrome, autistic disorder, and schizophrenia-like disorder. (8331056)
1993
50
Autistic disorder in Sotos syndrome: a case report. (2347353)
1990

Variations for Autistic Disorder

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Expression for genes affiliated with Autistic Disorder

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Expression patterns in normal tissues for genes affiliated with Autistic Disorder

Search GEO for disease gene expression data for Autistic Disorder.

Pathways for genes affiliated with Autistic Disorder

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Compounds for genes affiliated with Autistic Disorder

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Compounds related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1mpdt2810.1HTR5A, HTR7
2[3h]5-ct2810.1HTR5A, HTR7
3emdt2810.1HTR5A, HTR7
48-oh-dpat2810.1HTR5A, HTR7
55-ct2810.1HTR7, HTR5A
65-ht2810.1HTR5A, HTR7
7methiothepin44 2811.0HTR5A, HTR7
8ritanserin44 2811.0HTR5A, HTR7
9metergoline44 2811.0HTR7, HTR5A
10methysergide44 28 1112.0HTR5A, HTR7
11ketanserin44 2811.0HTR5A, HTR7
12Serotonin249.9HTR5A, HTR7
13sumatriptan44 28 61 50 24 1114.9HTR7, HTR5A
14yohimbine44 2 28 1112.8HTR5A, HTR7
15clozapine44 28 50 1112.8HTR5A, HTR7
16risperidone44 50 28 61 24 1114.7HTR7, SCT
17amine449.5HTR7, SCT

GO Terms for genes affiliated with Autistic Disorder

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Biological processes related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.8HTR7, HTR5A
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.7HTR5A, HTR7
3facial nucleus developmentGO:0217549.3HOXB1, HOXA1
4rhombomere 4 developmentGO:0215709.3HOXB1, HOXA1
5rhombomere 5 developmentGO:0215719.2HOXA1, HOXB1
6facial nerve structural organizationGO:0216129.2HOXB1, HOXA1
7anterior/posterior pattern specificationGO:0099529.1HOXA1, HOXB1
8multicellular organismal developmentGO:0072758.5HOXB1, HOXA1, EN2

Molecular functions related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.8HTR7, HTR5A
2sequence-specific DNA bindingGO:0435658.0HOXA1, EN2, ARX, HOXB1
3sequence-specific DNA binding transcription factor activityGO:0037007.7ARX, EN2, MBD1, HOXA1, HOXB1

Products for genes affiliated with Autistic Disorder

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  • Antibodies
  • Proteins
  • Lysates

Sources for Autistic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet