MCID: ATS001
MIFTS: 72

Autistic Disorder malady

Neuronal diseases category

Summaries for Autistic Disorder

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Sources:
8Disease Ontology, 33MedlinePlus, 43NINDS, 63Wikipedia, 46OMIM, 32MalaCards
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MedlinePlus:33 Autism is a disorder that is usually diagnosed in early childhood. the main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. children with autism might have problems talking with you, or they might not look you in the eye when you talk to them. they may spend a lot of time putting things in order before they can pay attention, or they may say the same sentence again and again to calm themselves down. they often seem to be in their "own world." because people with autism can have very different features or symptoms, health care providers think of autism as a "spectrum" disorder. asperger syndrome is a milder version of the disorder. the cause of autism is not known. autism lasts throughout a person's lifetime. there is no cure, but treatment can help. treatments include behavior and communication therapies and medicines to control symptoms. starting treatment as early as possible is important. nih: national institute of child health and human development

MalaCards: Autistic Disorder, also known as autism, is related to asperger syndrome and pervasive developmental disorder. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Circadian entrainment and Neural Crest Differentiation. The drugs fenfluramine and risperidone and the compounds mpdt and yohimbine have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

NINDS:43 Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).

Wikipedia:63 Autism is a disorder of neural development characterized by impaired social interaction and verbal and... more...

Description from OMIM:46 613436, 300496, 608636, 300830, 613410 209850, 300495, 300425, 612100, 611913 more

Aliases & Classifications for Autistic Disorder

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Sources:
8Disease Ontology, 20GeneTests, 22GTR, 43NINDS, 10DISEASES, 44Novoseek, 33MedlinePlus, 30LifeMap Discovery™, 60UMLS, 56SNOMED-CT, 46OMIM, 34MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal diseases


Aliases & Descriptions:

autistic disorder 8 20 10 30 60
autism 8 20 22 43 33
autistic disorder of childhood onset 8 22
infantile psychosis 8 60
kanner's syndrome 8
infantile autism 8
childhood autism 8
autistic 44


Related Diseases for Autistic Disorder

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Autistic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 328)
idRelated DiseaseScoreTop Affiliating Genes
1asperger syndrome31.2NLGN3, NLGN4Y
2pervasive developmental disorder30.7SCT
3schizophrenia30.3HTR7, SCT
4intellectual disability30.1ARX, UBE3A
5rett syndrome29.9DLX5, UBE3A
6fragile x syndrome10.6
7developmental disabilities10.6
8adult syndrome10.4
9attention deficit hyperactivity disorder10.4
10neuronitis10.3
11angelman syndrome10.3
12cerebral palsy10.2
13autism susceptibility 1610.2
14autism susceptibility 1510.2
15autism susceptibility 1710.2
16autism 1810.2
17autism susceptibility, x-linked 210.2
18autism susceptibility, x-linked 110.2
19autism susceptibility, x-linked 310.2
20autism x-linked 510.2
21alexithymia10.2
22conduct disorder10.2
23echolalia10.2
24epsilon-trimethyllysine hydroxylase deficiency10.2
25obsessive-compulsive disorder10.2
26anxiety disorder10.2
27bipolar disorder10.2
28macrocephaly/autism syndrome10.1
29smith-lemli-opitz syndrome10.1
30neurofibromatosis10.1
31prader-willi syndrome10.1
32brain disease10.1
33charge syndrome10.1
34asperger syndrome susceptibility, x-linked 210.1
35asperger syndrome susceptibility, x-linked 110.1
36mental retardation with language impairment and autistic features10.1
37rubella10.1
38cerebritis10.1
39autism spectrum disorder10.1
40personality disorder10.1
41speech disorder10.1
42borna disease10.1
43lyme disease10.1
44mutism10.1
45fetal alcohol spectrum disorder10.1
46cohen syndrome10.0
47bruxism10.0
48x-linked ichthyosis10.0
49cornelia de lange syndrome10.0
50bipolar i disorder10.0

Graphical network of the top 20 diseases related to Autistic Disorder:



Diseases related to autistic disorder

Clinical Features for Autistic Disorder

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Sources:
46OMIM
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Clinical features from OMIM:

613436,300496,608636,300830,613410,209850,300495,300425,612100,611913

Drugs & Therapeutics for Autistic Disorder

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 30LifeMap Discovery™, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autistic Disorder

Drug clinical trials:

Search ClinicalTrials for Autistic Disorder

Search NIH Clinical Center for Autistic Disorder

Search CenterWatch for Autistic Disorder

Inferred drug relations via UMLS60/NDF-RT40:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autistic Disorder cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Autistic Disorder:
NU211-01/NC215-01, human umbilical cord mesenchymal stem cells for patients with autism
Embryonic/Adult Cultured Cells Related to Autistic Disorder:
Umbilical cord-derived mesenchymal stem cells
Umbilical cord blood-derived mononuclear cells

Genetic Tests for Autistic Disorder

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Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Autistic Disorder:

id Genetic test Affiliating Genes
1 Autism Multi-Gene Panels20
2 Autistic Disorder20 SNRPN
3 Autistic Disorder of Childhood Onset22
4 Autism22

Anatomical Context for Autistic Disorder

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Sources:
30LifeMap Discovery™, 32MalaCards
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MalaCards organs/tissues related to Autistic Disorder:

32
Brain, Eye, Testes, Cortex, Monocytes, Amygdala

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autistic Disorder:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autistic Disorder or affiliated genes

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Sources:
36MGI
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MGI Mouse Phenotypes related to Autistic Disorder:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:000538610.5PER1, NLGN2, NLGN3, UBE3A, MBD1, HTR7
2MP:000363110.5HTR7, MBD1, UBE3A, NLGN3, NLGN2, SCT
3MP:000301210.4NLGN3, UBE3A, GABRA5, OMG, HOXB1, HOXA1
4MP:001076810.4ARX, HTR7, UBE3A, NLGN3, NLGN2, SSBP1
5MP:000287310.4NLGN3, HTR5A, ARX, OMG, HOXB1, HOXA1
6MP:000537610.4HTR7, SCT, ARX, OMG, HOXA1, WNT2
7MP:000538810.3NLGN2, NLGN3, HOXB1, HOXA1, DLX5, WNT2
8MP:000537810.0NLGN2, NLGN3, UBE3A, ARX, HOXB1, DLX5

Publications for Autistic Disorder

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Sources:
50PubMed
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Articles related to Autistic Disorder:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
A nationwide study of the association between celiac disease and the risk of autistic spectrum disorders. (24068245)
2013
2
Aripiprazole treatment of irritability associated with autistic disorder and the relationship between prior antipsychotic exposure, adverse events, and weight change. (24138011)
2013
3
Does Gender Matter? A One Year Follow-up of Autistic, Attention and Anxiety Symptoms in High-Functioning Children with Autism Spectrum Disorder. (24105364)
2013
4
Memantine as adjunctive treatment to risperidone in children with autistic disorder: a randomized, double-blind, placebo-controlled trial. (22999292)
2013
5
Differentiating children with attention-deficit/hyperactivity disorder, conduct disorder, learning disabilities and autistic spectrum disorders by means of their motor behavior characteristics. (22093665)
2012
6
Ferritin and iron levels in children with autistic disorder. (21643649)
2012
7
Investigating autism spectrum disorder and autistic traits in early onset eating disorder. (22331792)
2012
8
Comment on "timing of increased autistic disorder cumulative incidence". (22191468)
2012
9
Riluzole in autistic disorder. (21823915)
2011
10
Effects of symptoms of co-morbid psychopathology on challenging behaviours among infants and toddlers with Autistic Disorder and PDD-NOS as assessed with the Baby and Infant Screen for Children with aUtIsm Traits (BISCUIT). (21548853)
2011
11
Attention deficit hyperactivity symptoms in children with autistic disorder: a cross-sectional descriptive study. (21534371)
2011
12
A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. (19797985)
2009
13
Pain reactivity and plasma beta-endorphin in children and adolescents with autistic disorder. (19707566)
2009
14
Co-occurrence of X-linked congenital adrenal hypoplasia and autistic disorder. (19622699)
2009
15
Comparison of long-term efficacy and safety of risperidone and haloperidol in children and adolescents with autistic disorder. An open label maintenance study. (18026891)
2008
16
Childhood and current autistic features in adolescents with schizotypal personality disorder. (18554872)
2008
17
Use of atypical antipsychotics in the treatment of autistic disorder. (17389666)
2007
18
Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotype. (17404132)
2007
19
Tetrasomy 15q11-q13 diagnosed by FISH in a patient with autistic disorder. (17541469)
2007
20
Autonomic and neuroendocrine responses to a psychosocial stressor in adults with autistic spectrum disorder. (16865550)
2006
21
Screening of subtelomeric rearrangements in autistic disorder: identification of a partial trisomy of 13q34 in a patient bearing a 13q;21p translocation. (16823807)
2006
22
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. (15652871)
2005
23
A pilot study of D-cycloserine in subjects with autistic disorder. (15514414)
2004
24
Impairment of a cortical event-related desynchronisation during a bimanual load-lifting task in children with autistic disorder. (15337253)
2004
25
High blood monocyte counts and neopterin levels in children with autistic disorder. (12944347)
2003
26
Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. (12566166)
2003
27
Mutation screening of FOXP2 in individuals diagnosed with autistic disorder. (12655497)
2003
28
Parental identification of early behavioural abnormalities in children with autistic disorder. (12846383)
2003
29
Dermatoglyphs of digito-palmar complex in autistic disorder: family analysis. (12950152)
2003
30
Exploring the borderlands of autistic disorder and specific language impairment: a study using standardised diagnostic instruments. (12405479)
2002
31
Investigation of antioxidant enzymes in children with autistic disorder. (12445495)
2002
32
Exclusion of the coding sequence of the doublecortin gene as a susceptibility locus in autistic disorder. (11857568)
2002
33
Being in a fragmented and isolated world: interviews with carers working with a person with a severe autistic disorder. (11872104)
2002
34
Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. (12092907)
2001
35
Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. (11317216)
2001
36
Full-genome scans with autistic disorder: a review. (11529268)
2001
37
Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. (10686565)
2000
38
Occurrence of tics in Asperger's syndrome and autistic disorder. (10868783)
2000
39
Chromosomal abnormalities in a series of children with autistic disorder. (10478727)
1999
40
Niaprazine in the treatment of autistic disorder. (10456769)
1999
41
Chromosome 15q11-13 region and the autistic disorder. (9678411)
1998
42
Hyperkinesias in a prepubertal boy with autistic disorder treated with haloperidol and valproic acid. (9122323)
1997
43
Dyskinesias subside off all medication in a boy with autistic disorder and severe mental retardation. (9400068)
1997
44
An open clinical trial of risperidone monotherapy in young children with autistic disorder. (9133768)
1997
45
Brief report: comorbid psychiatric disorders of autistic disorder. (8744477)
1996
46
Longitudinal examination of the behavioral, language, and social changes in a population of adolescents and young adults with autistic disorder. (8916159)
1996
47
Field trial for autistic disorder in DSM-IV. (8067493)
1994
48
Catecholamines in autistic disorder: effects of amisulpride and bromocriptine in a controlled crossover study. (19630674)
1993
49
Autistic disorder and post-traumatic stress disorder. (8282677)
1993
50
Serotonergic responsivity in male young adults with autistic disorder. Results of a pilot study. (2919950)
1989

Genetic Variations for Autistic Disorder

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Expression for genes affiliated with Autistic Disorder

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autistic Disorder

Search GEO for disease gene expression data for Autistic Disorder.

Pathways for genes affiliated with Autistic Disorder

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Sources:
29KEGG, 37NCBI BioSystems Database, 53Reactome, 12EMD Millipore, 52R&D Systems
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Compounds for genes affiliated with Autistic Disorder

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Sources:
28IUPHAR, 44Novoseek, 2BitterDB, 11DrugBank, 59Tocris Bioscience, 49PharmGKB, 24HMDB
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Compounds related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1mpdt2810.7HTR7, HTR5A
2yohimbine44 28 2 1113.7HTR7, HTR5A, TAS2R1
3[3h]5-ct2810.7HTR7, HTR5A
4emdt2810.7HTR5A, HTR7
5gaba4410.7DLX5, ARX, GABRA5, SCT, UBE3A
68-oh-dpat2810.7HTR5A, HTR7
75-ct2810.7HTR7, HTR5A
8methiothepin44 2811.6HTR5A, HTR7
9ritanserin28 4411.6HTR5A, HTR7
105-ht2810.6HTR5A, HTR7
11metergoline44 2811.5HTR7, HTR5A
12methysergide44 28 1112.5HTR5A, HTR7
13sumatriptan44 28 59 49 11 2415.5HTR5A, HTR7
14ketanserin28 4411.4HTR5A, HTR7
15benzodiazepine4410.1PER1, UBE3A

GO Terms for genes affiliated with Autistic Disorder

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16Gene Ontology
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Cellular components related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4GABRA5, NLGN3, NLGN2, NLGN4Y
2integral to plasma membraneGO:00588710.3GABRA5, HTR5A, HTR7, NLGN3, NLGN2, NLGN4Y
3synapseGO:04520210.1NLGN4Y, NLGN2, NLGN3

Biological processes related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1rhombomere 4 developmentGO:02157010.7HOXA1, HOXB1
2facial nucleus developmentGO:02175410.7HOXB1, HOXA1
3rhombomere 5 developmentGO:02157110.7HOXB1, HOXA1
4facial nerve structural organizationGO:02161210.7HOXB1, HOXA1
5synapse assemblyGO:00741610.7NLGN3, NLGN2, NLGN4Y
6postsynaptic membrane assemblyGO:09710410.7NLGN3, NLGN2
7anatomical structure formation involved in morphogenesisGO:04864610.7DLX5, HOXB1
8presynaptic membrane assemblyGO:09710510.6NLGN3, NLGN2
9serotonin receptor signaling pathwayGO:00721010.6HTR7, HTR5A
10positive regulation of excitatory postsynaptic membrane potentialGO:200046310.6NLGN3, NLGN2
11neuron cell-cell adhesionGO:00715810.6NLGN3, NLGN2
12regulation of respiratory gaseous exchange by neurological system processGO:00208710.5NLGN2, NLGN3
13cochlea developmentGO:09010210.4HOXA1, GABRA5
14positive regulation of transcription from RNA polymerase II promoterGO:04594410.4EN2, WNT2, HOXA1, HOXB1, UBE3A
15positive regulation of synaptic transmission, glutamatergicGO:05196810.3NLGN2, NLGN3
16positive regulation of synapse assemblyGO:05196510.1NLGN3, NLGN2

Molecular functions related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NLGN3, NLGN2
2neurexin family protein bindingGO:04204310.4NLGN3, NLGN2, NLGN4Y
3receptor activityGO:00487210.3NLGN4Y, NLGN2, NLGN3, GABRA5
4serotonin receptor activityGO:00499310.2HTR5A, HTR7

Products for genes affiliated with Autistic Disorder

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Sources for Autistic Disorder

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet