Autistic Disorder malady

MedlinePlus: Autism is a disorder that is usually first diagnosed in early childhood. the main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. children with autism might have problems talking with you, or they might not look you in the eye when you talk to them. they may have to line up their pencils before they can pay attention, or they may say the same sentence again and again to calm themselves down. they may flap their arms to tell you they are happy, or they might hurt themselves to tell you they are not. some people with autism never learn how to talk. because people with autism can have very different features or symptoms, health care providers think of autism as a "spectrum" disorder. asperger syndrome is a milder version of the disorder. the cause of autism is not known. autism lasts throughout a person's lifetime. there is no cure, but treatment can help. treatments include behavior and communication therapies and medicines to control symptoms. nih: national institute of child health and human development²³

MalaCards: Autistic Disorder, also known as autism, is related to asperger syndrome and adhd. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Metabolic States and Circadian Oscillators and Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics. The drugs venlafaxine and fenfluramine hydrochloride and the compounds way 100635 and benzodiazepine have been mentioned in the context of this disorder. Affiliated tissues include brain, and related mouse phenotypes are endocrine/exocrine gland and no phenotypic analysis.

Disease Ontology: An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.⁶

NINDS: Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).³¹

Wikipedia: Autism is a disorder of neural development characterized by impaired social interaction and...⁴⁴ more...

Aliases & Descriptions:

autistic disorder 6 16 43 autism 6 16 17 31 8 23 autistic disorder of childhood onset (disorder) 6 infantile psychosis (disorder) 6 infantile autism (disorder) 6

infantile psychosis 43 kanner's syndrome 6 childhood autism 6 autistic 32

Diseases related to autistic disorder by text searches and GeneDecks gene sharing:

(show top 50)    (show all 274)

id	Related Disease	Score	Top Affiliating Genes
1	asperger syndrome	31.2	MECP2, NLGN3, NLGN4X, OXT, SLC6A4
2	adhd	28.6	HTR2A, TPH2, OXTR, PRL, SLC6A4
3	angelman syndrome	28.3	UBE2K, UBE3A, MECP2, SNRPN, GABRA5, GABRB3
4	atypical autism	28.2	SNRPN, NLGN3, NLGN4X, OXTR, GABRB3
5	pervasive developmental disorder	28.1	SCT, FOXP2, MECP2, NLGN3, NLGN4X, SLC6A4
6	attention deficit hyperactivity disorder	28.1	MECP2, HTR2A, TPH2, SLC6A4
7	tourette syndrome	27.5	HTR2A, HTR3A, HTR7, TPH2, NLGN4X, OXT
8	rett syndrome	27.4	UBE3A, MECP2, MBD1, NTS, PRL, CSN1S1
9	social cognition	27.2	OXT, OXTR, SLC6A4
10	intellectual disability	27.2	RELN, BLMH, UBE3A, MECP2, SNRPN, NLGN3
11	language disorder	27.1	FOXP2, MECP2
12	tuberous sclerosis	26.9	MECP2, IFNG, NF1, TSC2, DCX
13	insomnia	26.8	CLOCK, HTR2A, HTR3A, SLC6A4, GABRB3
14	developmental disabilities	26.8	SCT, UBE3A, FOXP2, MECP2, DCX
15	anxiety disorder	26.3	HTR2A, HTR3A, TPH2, OXT, SLC6A4
16	alcoholism	26.1	SCT, HTR2A, HTR3A, TPH2, SLC6A4, GABRB3
17	albinism	26.0	MLPH, GSTP1, IFNG, SLC6A4, GABRA5
18	seizures	25.8	UBE3A, MECP2, EN2, HTR2A, TSC2, DCX
19	mood disorder	25.7	RELN, CLOCK, HTR2A, HTR3A, TPH2, SLC6A4
20	obsessive-compulsive disorder	25.4	HTR2A, HTR3A, TPH2, OXT, PRL, SLC6A4
21	blindness	24.9	SERPINE1, SCT, UBE3A, IFNG, HTR2A, HTR3A
22	schizophrenia	23.9	RELN, CLOCK, SCT, FOXP2, GSTP1, MECP2
23	down syndrome	23.3	SERPINE1, GSTP1, MECP2, IFNG, PRL, CSN1S1
24	homocysteine	23.3	SERPINE1, BLMH, GSTP1, IFNG, PRKCB, PRL
25	bipolar disorder	23.1	RELN, CLOCK, HTR2A, HTR3A, TPH2, NTS
26	twinning	23.0	SERPINE1, MLPH, MECP2, IFNG, NF1, TSC2
27	cerebritis	22.0	RELN, SERPINE1, SCT, UBE2K, FOXP2, GSTP1
28	anorexia nervosa	22.0	SERPINE1, CLOCK, IFNG, HTR2A, HTR3A, HTR5A
29	autism spectrum disorder	21.1	RELN, SCT, UBE2H, UBE3A, FOXP2, MECP2
30	thyroiditis	20.3	RELN, SERPINE1, SCTR, SCT, GSTP1, MET
31	neuronitis	18.5	RELN, SERPINE1, CLOCK, SCT, UBE3A, FOXP2
32	mecp2-related severe neonatal encephalopathy	13.6	MECP2, OXT, ADSL
33	advanced sleep phase syndrome	13.4	CLOCK, TPH2, CSN1S1, PER1
34	pancreatic diseases	13.3	SCTR, SCT, NTS, ADA
35	carcinoid syndrome	13.3	HTR3A, HTR7, NTS
36	major affective disorder	13.2	HTR2A, HTR3A, SLC6A4
37	aicardi-goutieres syndrome	13.2	MECP2, TSC2, OXT, ADSL
38	neurotic disorder	13.2	HTR2A, HTR3A, SLC6A4
39	generalized anxiety disorder	13.2	HTR2A, HTR3A, SLC6A4
40	periventricular nodular heterotopia	13.1	RELN, TSC2, DCX
41	eating disorder	13.1	HTR2A, HTR3A, NTS, SLC6A4
42	postpartum depression	12.9	OXT, PRL, SLC6A4
43	von hippel-lindau disease	12.9	MET, NF1, TSC2, OXTR
44	focal epilepsy	12.9	TSC2, PRL, GABRA5
45	bipolar i disorder	12.9	CLOCK, HTR2A, TPH2, NPAS2, SLC6A4, PER1
46	borderline personality disorder	12.9	OXT, PRL, SLC6A4
47	antisocial personality disorder	12.9	HTR2A, PRL, SLC6A4
48	lung benign neoplasm	12.8	GSTP1, MECP2, MET, OXT, OXTR
49	heterotopia	12.8	RELN, NF1, DCX
50	social phobia	12.8	HTR3A, PRL, SLC6A4

Approved drugs:

Drug clinical trials:

Inferred drug relations via UMLS/NDF-RT:

^43 28 fenfluramine, fenfluramine hydrochloride, quetiapine, quetiapine fumarate, risperidone, venlafaxine, venlafaxine hydrochloride

MalaCards organs/tissues related to autistic disorder:

²²

MGI Mouse Phenotypes related to autistic disorder:

²⁵ (show all 13)

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	endocrine/exocrine gland phenotype	MP:0005379	8.7	OXTR, NF1, HTR2A, IFNG, MECP2
2	no phenotypic analysis	MP:0003012	8.0	NLGN3, DCX, OXTR, OMG, GABRA5, GABRB3
3	normal phenotype	MP:0002873	7.7	OXTR, OMG, SLC6A4, ADA, GABRB3, TSC2
4	renal/urinary system phenotype	MP:0005367	7.4	PER1, OXT, TSC2, NF1, HTR3A, IFNG
5	respiratory system phenotype	MP:0005388	7.4	ADA, WNT2, NF1, NLGN3, TPH2, HMGB1
6	reproductive system phenotype	MP:0005389	7.0	OXT, OXTR, PRL, CSN1S1, PER1, ADA
7	nervous system phenotype	MP:0003631	6.8	NTS, NLGN3, NF1, TSC2, DCX, PRKCB
8	cardiovascular system phenotype	MP:0005385	6.5	TSC2, OXT, PRKCB, NPAS2, SLC6A4, WNT2
9	integument phenotype	MP:0010771	5.7	TPH2, NF1, TSC2, OXT, OXTR, PRL
10	mortality/aging	MP:0010768	5.2	SNRPN, NLGN3, NF1, TSC2, DCX, OXT
11	growth/size phenotype	MP:0005378	4.9	TSC2, NF1, NLGN3, SNRPN, NTS, DCX
12	homeostasis/metabolism phenotype	MP:0005376	4.5	OXT, TSC2, NF1, SNRPN, NTS, PRKCB
13	behavior/neurological phenotype	MP:0005386	4.3	GABRB3, NTS, SNRPN, NLGN3, NF1, TSC2

Articles related to autistic disorder:

(show all 48)

id	Title	Authors	Year	Affiliating Genes
1	Neurotensin is increased in serum of young children w ith autistic disorder. (20731814)	Angelidou A.... Theoharides T.C.	2010	NTS
2	5-HT2A receptor gene polymorphisms in Croatian subjec ts with autistic disorder. (20471101)	Hranilovic D.... Jernej B.	2010	HTR2A
3	Increased serum levels of high mobility group box 1 p rotein in patients with autistic disorder. (20302902)	Emanuele E.... Politi P.	2010	HMGB1
4	Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. (19681062)	Jackson P.B.... Schwartz C.E.	2009	MET
5	Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high -functioning level. (19777562)	Wermter A.K.... Remschmidt H.	2009	OXTR
6	Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression. (18317465)	Lintas C.... Persico A.M.	2009	PRKCB
7	Two patients with balanced translocations and autistic disorder: CSMD3 as a candidate gene for autism found in their common 8q23 breakpoint area. (18270536)	Floris C.... Crisponi L.	2008	CSMD3
8	Buspirone for autistic disorder in a woman with an in tellectual disability. (18056831)	Brahm N.C.... Brown R.C.	2008	PRL
9	Association of the homeobox transcription factor gene ENGRAILED 2 with autistic disorder in Chinese children. (18424904)	Yang P.... Juo S.H.	2008	EN2
10	Risk of autistic disorder in affected offspring of mothers with a glutathione S-transferase P1 haplotype. (17404132)	Williams T.A.... Johnson W.G.	2007	GSTP1
11	Association of Per1 and Npas2 with autistic disorder: support for the clock genes/social timing hypothesis. (17264841)	Nicholas B.... Wimpory D.C.	2007	CLOCK, PER1, NPAS2
12	Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. (17346350)	Sacco R.... Persico A.M.	2007	GLO1, TPH2
13	Neurochemical correlates of autistic disorder: a revi ew of the literature. (16002261)	Lam K.S.... Arnold L.E.	2006	OXT
14	An analysis paradigm for investigating multi-locus effects in complex disease: examination of three GABA receptor subunit genes on 15q11-q13 as risk factors for autistic disorder. (16674551)	Ashley-Koch A.E.... Pericak-Vance M.A.	2006	GABRB3, GABRA5, GABRG3
15	Validity of childhood disintegrative disorder apart from autistic disorder with speech loss. (15365892)	Kurita H.... Osada H.	2004	ADSL
16	Deletion 2q37.3 and autism: molecular cytogenetic mapping of the candidate region for autistic disorder. (15517821)	Lukusa T.... Devriendt K.	2004	MLPH
17	Association between the FOXP2 gene and autistic disorder in Chinese population. (15108192)	Gong X.... Zhang D.	2004	FOXP2
18	High nitric oxide production in autistic disorder: a possible role for interferon-gamma. (14960298)	Sweeten T.L.... McDougle C.J.	2004	IFNG
19	Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. (12566166)	Vourc'h P.... Andres C.	2003	OMG
20	Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. (14627686)	Serajee F.J.... Mahbubul Huq A.H.	2003	TSC2
21	Mutation screening of FOXP2 in individuals diagnosed with autistic disorder. (12655497)	Gauthier J.... Rouleau G.A.	2003	FOXP2
22	No association between the EN2 gene and autistic disorder. (12525552)	Zhong H.... Huq A.H.	2003	EN2
23	Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. (14639049)	Vourc'h P.... Andres C.	2003	UBE3A, UBE2H, UBE2K
24	Identification of MeCP2 mutations in a series of females with autistic disorder. (12770674)	Carney R.M.... Pericak-Vance M.A.	2003	MECP2, MBD1
25	Serotonin 2A receptor gene polymorphism and clinical efficacy of fluvoxamine in children with autistic disorder (12607287)	Sugie Y.... Ohzeki T.	2003	HTR3A, HTR2A
26	Molecular genetics and animal models in autistic disorder. (11827743)	Andres C.	2002	WNT2
27	Serotonin transporter gene polymorphisms and hyperserotonemia in autistic disorder. (11803447)	Betancur C.... Leboyer M.	2002	SLC6A4
28	Exclusion of the coding sequence of the doublecortin gene as a susceptibility locus in autistic disorder. (11857568)	Vourc'h P.... Barthelemy C.	2002	DCX
29	No association between the WNT2 gene and autistic disorder. (11840514)	McCoy P.A.... Pericak-Vance M.A.	2002	WNT2
30	Transmission disequilibrium mapping at the serotonin transporter gene (SLC6A4) region in autistic disorder. (11920155)	Kim S.J.... Cook E.H.	2002	BLMH, SLC6A4
31	Reduced blood levels of reelin as a vulnerability factor in pathophysiology of autistic disorder. (12363196)	Fatemi S.H.... Egan E.A.	2002	RELN
32	Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. (12092907)	Menold M.M.... Gilbert J.R.	2001	GABRB3, GABRA5
33	A balanced reciprocal translocation t(5;7)(q14;q32) associated with autistic disorder: molecular analysis of the chromosome 7 breakpoint. (11803521)	Tentler D.... Dahl N.	2001	SSBP1
34	Reelin gene alleles and haplotypes as a factor predisposing to autistic disorder. (11317216)	Persico A.M.... Keller F.	2001	RELN
35	Oxytocin and autistic disorder: alterations in peptide forms. (11690596)	Green L.... Morris M.	2001	OXT
36	No association between the 4g/5G polymorphism of the plasminogen activator inhibitor-1 gene promoter and autistic disorder. (11525425)	Persico A.M.... Keller F.	2001	SERPINE1
37	Reports on dietary intervention in autistic disorders . (11842874)	Knivsber A.M.... dland M.	2001	CSN1S1
38	Genetic studies in autistic disorders (11055182)	SA8opieA8 A.... Rajewski A.	2000	SLC6A4
39	Adenosine deaminase alleles and autistic disorder: case-control and family-based association studies. (11121182)	Persico A.M.... Keller F.	2000	ADA
40	Lack of association between serotonin transporter gene promoter variants and autistic disorder in two ethnically distinct samples. (10686565)	Persico A.M.... Keller F.	2000	SLC6A4
41	Regarding secretin for treating autistic disorder. (10819123)	Aman M.G.... Armstrong S.A.	2000	SCT
42	Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. (10490701)	Lassig J.P.... Cook E.H.	1999	HTR7
43	Gastrointestinal abnormalities in children with autistic disorder. (10547242)	Horvath K.... Tildon J.T.	1999	SCTR, SCT
44	Mutation screening of the UBE3A/E6-AP gene in autistic disorder. (10089011)	Veenstra-VanderWeele J.... Cook E.H.	1999	UBE3A
45	Autistic disorder and chromosome 15q11-q13: construction and analysis of a BAC/PAC contig. (10644429)	Maddox L.O.... Gilbert J.R.	1999	GABRB3, GABRA5
46	Genetic studies of autistic disorder and chromosome 7. (10552924)	Ashley-Koch A.... Pericak-Vance M.A.	1999	EN2
47	Association study of the NF1 gene and autistic disorder. (10581497)	Mbarek O.... Andres C.	1999	NF1
48	Evidence of linkage between the serotonin transporter and autistic disorder. (9152989)	Cook E.H.... Leventhal B.L.	1997	SLC6A4

Genes related to autistic disorder according to GeneCards:

(show all 48)

id	Symbol	Description	Score	GeneCards Section Context
1	HTR7	5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled	11.1	Summaries, Functions, Publications
2	OMG	oligodendrocyte myelin glycoprotein	11.0	Publications
3	EN2	engrailed homeobox 2	11.0	Publications
4	MBD1	methyl-CpG binding domain protein 1	11.0	Publications
5	WNT2	wingless-type MMTV integration site family member 2	11.0	Publications
6	HTR5A	5-hydroxytryptamine (serotonin) receptor 5A, G protein-coupled	11.0	Functions
7	BLMH	bleomycin hydrolase	11.0	Publications
8	ADSL	adenylosuccinate lyase	11.0	Publications
9	SSBP1	single-stranded DNA binding protein 1, mitochondrial	11.0	Publications
10	GLO1	glyoxalase I	11.0	Publications
11	PER1	period homolog 1 (Drosophila)	11.0	Publications
12	GABRA5	gamma-aminobutyric acid (GABA) A receptor, alpha 5	11.0	Publications
13	NLGN3	neuroligin 3	11.0
14	SCTR	secretin receptor	11.0	Publications
15	UBE3A	ubiquitin protein ligase E3A	11.0	Publications
16	SCT	secretin	11.0	Publications
17	MLPH	melanophilin	11.0	Publications
18	NTS	neurotensin	11.0	Publications
19	UBE2H	ubiquitin-conjugating enzyme E2H	11.0	Publications
20	UBE2K	ubiquitin-conjugating enzyme E2K	11.0	Publications
21	OXTR	oxytocin receptor	11.0	Publications
22	DCX	doublecortin	11.0	Publications
23	NPAS2	neuronal PAS domain protein 2	11.0	Publications
24	HMGB1	high mobility group box 1	11.0	Publications
25	TPH2	tryptophan hydroxylase 2	11.0	Publications
26	CLOCK	clock homolog (mouse)	11.0	Publications
27	OXT	oxytocin, prepropeptide	11.0	Publications
28	SLC6A4	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	11.0	Publications
29	SNRPN	small nuclear ribonucleoprotein polypeptide N	11.0
30	MECP2	methyl CpG binding protein 2 (Rett syndrome)	11.0	Publications
31	CSN1S1	casein alpha s1	11.0	Publications
32	GABRB3	gamma-aminobutyric acid (GABA) A receptor, beta 3	11.0	Publications
33	TSC2	tuberous sclerosis 2	11.0	Publications
34	FOXP2	forkhead box P2	11.0	Publications
35	HTR3A	5-hydroxytryptamine (serotonin) receptor 3A, ionotropic	11.0	Publications
36	ADA	adenosine deaminase	11.0	Publications
37	RELN	reelin	11.0	Publications
38	MET	met proto-oncogene (hepatocyte growth factor receptor)	11.0	Publications
39	HTR2A	5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled	11.0	Publications
40	NLGN4X	neuroligin 4, X-linked	11.0
41	NF1	neurofibromin 1	11.0	Publications
42	GSTP1	glutathione S-transferase pi 1	11.0	Publications
43	GABRG3	gamma-aminobutyric acid (GABA) A receptor, gamma 3	11.0	Publications
44	PRKCB	protein kinase C, beta	11.0	Publications
45	PRL	prolactin	11.0	Publications
46	CSMD3	CUB and Sushi multiple domains 3	11.0	Publications
47	SERPINE1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	11.0	Publications
48	IFNG	interferon, gamma	11.0	Publications

Pathways related to autistic disorder according to GeneDecks:

id	Pathway	Score	Top Affiliating Genes
1	Metabolic States and Circadian Oscillators36	10.0	PER1, NPAS2, CLOCK
2	Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics34	9.8	HTR2A, TPH2, SLC6A4
3	Circadian rhythm - mammal20	9.8	CLOCK, NPAS2, PER1
4	Calcium signaling pathway20	9.4	HTR2A, HTR5A, HTR7, OXTR, PRKCB
5	GABA signaling in brain10	9.2	MECP2, GABRG3, GABRB3, GABRA5, NLGN4X, NLGN3
6	Neuroactive ligand-receptor interaction20	8.6	GABRG3, GABRB3, GABRA5, PRL, OXTR, HTR7

Compounds related to autistic disorder according to GeneDecks:

(show top 50)    (show all 154)

id	Compound	Score	Top Affiliating Genes
1	way 10063532 42	11.2	HTR7, HTR3A, HTR2A
2	benzodiazepine32	10.1	UBE3A, NTS, PER1, HTR3A
3	gr 12793532	10.1	HTR2A, HTR3A, HTR7
4	8-hydroxy-2-(di-n-propylamino)tetralin32	10.1	SLC6A4, HTR7, HTR3A, HTR2A
5	venlafaxine32 34 9 18 9	13.9	HTR3A, TPH2, SLC6A4, HTR2A
6	fluvoxamine32 34 9 9	12.9	CLOCK, HTR3A, HTR2A, SLC6A4
7	amisulpride32 9 9	11.9	HTR2A, PRL, HTR7
8	metergoline32	9.7	HTR7, HTR2A, PRL, HTR3A
9	lorazepam32 34 9 9	12.7	HTR3A, GABRA5, GABRB3, GABRG3
10	diazepam32 34 9 9	12.7	OXT, CSN1S1, GABRA5, GABRB3, GABRG3
11	zotepine32	9.7	PRL, HTR3A, HTR2A
12	buspirone32 9 9	11.7	SCT, HTR2A, HTR3A, PRL
13	m-chlorophenylpiperazine32	9.7	PRL, SLC6A4, HTR2A, HTR3A
14	ipsapirone32	9.6	PRL, OXT, HTR3A, HTR2A
15	mcpp32	9.6	SLC6A4, HTR3A, PRL, HTR2A
16	pindolol32 9 9	11.6	HTR3A, PRL, HTR2A, SLC6A4
17	5-hydroxytryptophan32	9.6	PRL, SLC6A4, HTR2A, HTR3A
18	fenfluramine32 9 9	11.6	HTR2A, SLC6A4, HTR3A, PRL
19	olanzapine32 34 9 18 9	13.5	HTR2A, HTR3A, NTS, HTR7, PRL
20	melatonin32 42 9 18 9	13.5	PER1, NTS, HTR3A, OXT, CLOCK, PRL
21	acetylcholine32 9 18 9	12.5	ADA, SCTR, SCT, HTR3A, HTR7, CSN1S1
22	mirtazapine32 34 9 9	12.5	SLC6A4, TPH2, HTR3A, HTR2A, PRL
23	risperidone32 34 9 18 9	13.5	SCT, HTR2A, HTR3A, PRL, SLC6A4
24	clozapine32 34 9 9	12.5	HTR3A, HTR2A, PRL, SLC6A4, NTS
25	opiate32	9.3	CSN1S1, NTS, SLC6A4, OXT, PRL
26	aripiprazole32 34 9 18 9	13.3	HTR3A, HTR2A, PRL, HTR7
27	ziprasidone32 9 9	11.3	HTR2A, PRL, HTR7, HTR3A
28	gnrh32	9.3	NTS, PRKCB, SERPINE1, OXTR
29	glutamate32	9.3	CSN1S1, ADA, ADSL, OXT, FOXP2, MECP2
30	clomipramine32 34 9 9	12.3	GSTP1, PRL, SLC6A4, HTR3A, HTR2A
31	fluoxetine32 34 9 9	12.2	PRL, OXT, TPH2, HTR3A, HTR2A, SCT
32	imipramine32 34 9 18 9	13.1	SLC6A4, HTR3A, HTR2A, IFNG, GSTP1
33	paroxetine32 34 9 9	11.9	HTR2A, SLC6A4, PRL, HTR3A
34	norepinephrine32 9 18 9	11.9	SLC6A4, PRL, OXT, NTS, HTR3A, HTR2A
35	creatinine32	8.8	GSTP1, GLO1, HMGB1, OXT, PRKCB, CSN1S1
36	phosphoinositide32	8.6	OXT, OXTR, MET, TSC2, HTR2A, FOXP2
37	gaba32 42	9.6	SLC6A4, UBE3A, RELN, NTS, GABRG3, GABRB3
38	epinephrine32 9 18 9	11.6	SLC6A4, PRL, NTS, OXT, GSTP1, SCT
39	atp32	8.5	MET, ADSL, CSN1S1, ADA, SCT, HMGB1
40	5-hydroxytryptamine32	8.2	PRL, NTS, TPH2, HTR7, HTR3A, HTR2A
41	cysteine32	8.2	UBE3A, GSTP1, UBE2K, SCT, SCTR, BLMH
42	adenylate32	7.9	NF1, SERPINE1, ADA, OXTR, TSC2, ADSL
43	alanine32	7.9	GLO1, NTS, NF1, OXTR, PRKCB, CSN1S1
44	dopamine32 9 18 9	10.4	PRKCB, NF1, NTS, HTR3A, HTR2A, GSTP1
45	testosterone32 9 18 9	10.4	MET, SERPINE1, SCT, GSTP1, MECP2, HMGB1
46	arginine32	7.2	MECP2, MET, SCT, GSTP1, PER1, IFNG
47	vegf32	7.2	ADA, WNT2, PRKCB, OXTR, SERPINE1, FOXP2
48	retinoic acid32 42 18	8.9	ADA, PRKCB, SERPINE1, GSTP1, WNT2, CSN1S1
49	serine32	6.8	NTS, DCX, HMGB1, NF1, RELN, MET
50	estrogen32	6.6	TPH2, HMGB1, MET, GSTP1, FOXP2, UBE3A

Cellular components related to autistic disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	excitatory synapse	GO:060076	9.7	NLGN4X, NLGN3, MET
2	dendrite	GO:030425	9.3	GABRA5, DCX, NF1, NLGN4X, HTR5A, RELN
3	postsynaptic membrane	GO:045211	8.9	GABRG3, GABRB3, GABRA5, NLGN4X, HTR3A, MET
4	cell junction	GO:030054	8.5	GABRG3, GABRB3, GABRA5, ADA, NLGN4X, NLGN3
5	integral to plasma membrane	GO:005887	8.4	SCTR, GABRB3, GABRA5, SLC6A4, OXTR, NLGN4X
6	plasma membrane	GO:005886	5.7	OMG, CSMD3, SLC6A4, WNT2, ADA, GABRA5

Biological processes related to autistic disorder according to GeneDecks:

(show all 18)

id	Name	GO ID	Score	Top Affiliating Genes
1	sperm ejaculation	GO:042713	10.3	OXT, OXTR, SLC6A4
2	positive regulation of synaptic transmission, glutamatergic	GO:051968	10.2	OXTR, NLGN3, RELN
3	positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	GO:2000969	10.2	NLGN3, RELN
4	negative regulation of gastric acid secretion	GO:060455	10.2	OXTR, OXT
5	positive regulation of synapse assembly	GO:051965	10.2	MECP2, NLGN3, OXT, OXTR
6	sleep	GO:030431	10.1	HTR2A, OXT, OXTR
7	serotonin receptor signaling pathway	GO:007210	10.1	HTR5A, HTR3A, HTR2A
8	circadian rhythm	GO:007623	10.1	PER1, SLC6A4, TPH2, HTR7, CLOCK
9	response to cocaine	GO:042220	10.1	HTR3A, OXT, OXTR
10	positive regulation of norepinephrine secretion	GO:010701	10.1	OXTR, OXT
11	memory	GO:007613	9.9	HTR2A, OXT, OXTR, SLC6A4
12	response to estradiol stimulus	GO:032355	9.9	SLC6A4, OXTR, OXT, HTR5A
13	ion transmembrane transport	GO:034220	9.7	HTR3A, GABRA5, GABRB3, GABRG3
14	social behavior	GO:035176	9.7	MECP2, NLGN3, NLGN4X, OXT, OXTR, SLC6A4
15	response to hypoxia	GO:001666	9.5	ADA, ADSL, SLC6A4, NF1, MECP2
16	brain development	GO:007420	9.5	GABRA5, DCX, NF1, MET, UBE3A, RELN
17	response to glucocorticoid stimulus	GO:051384	8.9	TPH2, HMGB1, SERPINE1, OXT
18	synaptic transmission	GO:007268	8.9	GABRG3, GABRB3, GABRA5, PRKCB, HTR7, HTR3A

Molecular functions related to autistic disorder according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	GABA-A receptor activity	GO:004890	9.8	GABRA5, GABRB3, GABRG3
2	serotonin receptor activity	GO:004993	9.7	HTR2A, HTR3A, HTR5A, HTR7
3	extracellular ligand-gated ion channel activity	GO:005230	9.2	GABRG3, GABRB3, GABRA5, HTR3A