MCID: ATS001
MIFTS: 71

Autistic Disorder malady

Genetic diseases (common), Mental diseases, Fetal diseases categories

Summaries for Autistic Disorder

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Sources:
9Disease Ontology, 35MedlinePlus, 45NINDS, 66Wikipedia, 48OMIM, 34MalaCards
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MedlinePlus:35 Autism is a disorder that is usually diagnosed in early childhood. the main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. children with autism might have problems talking with you, or they might not look you in the eye when you talk to them. they may spend a lot of time putting things in order before they can pay attention, or they may say the same sentence again and again to calm themselves down. they often seem to be in their "own world." because people with autism can have very different features or symptoms, health care providers think of autism as a "spectrum" disorder. asperger syndrome is a milder version of the disorder. the cause of autism is not known. autism lasts throughout a person's lifetime. there is no cure, but treatment can help. treatments include behavior and communication therapies and medicines to control symptoms. starting treatment as early as possible is important. nih: national institute of child health and human development

MalaCards: Autistic Disorder, also known as autism, is related to asperger syndrome and fragile x syndrome. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. The drugs fenfluramine and risperidone and the compounds mpdt and [3h]5-ct have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and testes, and related mouse phenotypes are no phenotypic analysis and normal.

Disease Ontology:9 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

NINDS:45 Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).

Wikipedia:66 Autism is a neurodevelopmental disorder characterized by impaired social interaction, verbal and... more...

Description from OMIM:48 209850, 613436, 300830, 611913, 613410 300425, 300495, 612100, 300496, 608636 more

Aliases & Classifications for Autistic Disorder

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Sources:
9Disease Ontology, 21GeneTests, 23GTR, 45NINDS, 11DISEASES, 46Novoseek, 35MedlinePlus, 32LifeMap Discoveryā„¢, 63UMLS, 59SNOMED-CT, 48OMIM, 28ICD9CM, 36MeSH, 26ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases (common), Fetal diseases
Anatomical: Mental diseases


Aliases & Descriptions:

autistic disorder 9 21 11 32 63
autism 9 21 23 45 35
autistic disorder of childhood onset 9 23
infantile psychosis 9 63
kanner's syndrome 9
childhood autism 9
infantile autism 9
autistic 46


Related Diseases for Autistic Disorder

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Sources:
18GeneCards, 19GeneDecks
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Diseases related to Autistic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 365)
idRelated DiseaseScoreTop Affiliating Genes
1asperger syndrome10.9
2fragile x syndrome10.7
3developmental disabilities10.6
4blindness10.6
5pervasive developmental disorder10.5
6williams syndrome10.5
7attention deficit hyperactivity disorder10.4
8mental retardation10.4
9pervasive developmental disorder not otherwise specified10.4
10neuronitis10.4
11angelman syndrome10.3
12schizophrenia10.3
13cerebral palsy10.3
14autism susceptibility 1610.3
15autism susceptibility 1510.3
16autism susceptibility 1710.3
17autism 1810.3
18autism susceptibility, x-linked 210.3
19autism susceptibility, x-linked 110.3
20autism susceptibility, x-linked 310.3
21autism x-linked 510.3
22alexithymia10.2
23echolalia10.2
24epsilon-trimethyllysine hydroxylase deficiency10.2
25bipolar disorder10.2
26macrocephaly/autism syndrome10.2
27neurofibromatosis10.1
28charge syndrome10.1
29prader-willi syndrome10.1
30asperger syndrome susceptibility, x-linked 210.1
31asperger syndrome susceptibility, x-linked 110.1
32mental retardation with language impairment and autistic features10.1
33rubella10.1
34obsessive-compulsive disorder10.1
35cerebritis10.1
36autism spectrum disorder10.1
37intellectual disability10.1
38childhood-onset schizophrenia10.1
39cytomegalovirus infection10.1
40borna disease10.1
41conduct disorder10.1
42lyme disease10.1
43mutism10.1
44smith-lemli-opitz syndrome10.1
45fetal alcohol spectrum disorder10.1
46megalencephaly10.1
47endotheliitis10.1
48scurvy10.1
49cohen syndrome10.1
50x-linked ichthyosis10.0

Graphical network of the top 20 diseases related to Autistic Disorder:



Diseases related to autistic disorder

Symptoms for Autistic Disorder

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Sources:
48OMIM
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Clinical features from OMIM:

209850,613436,300830,611913,613410,300425,300495,612100,300496,608636

Drugs & Therapeutics for Autistic Disorder

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Sources:
6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials, 32LifeMap Discoveryā„¢, 63UMLS, 42NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autistic Disorder

Drug clinical trials:

Search ClinicalTrials for Autistic Disorder

Search NIH Clinical Center for Autistic Disorder

Search CenterWatch for Autistic Disorder

Inferred drug relations via UMLS63/NDF-RT42:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autistic Disorder cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Autistic Disorder:
NU211-01/NC215-01, human umbilical cord mesenchymal stem cells for patients with autism
Embryonic/Adult Cultured Cells Related to Autistic Disorder:
Umbilical cord-derived mesenchymal stem cells
Umbilical cord blood-derived mononuclear cells

Genetic Tests for Autistic Disorder

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Sources:
21GeneTests, 23GTR
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Genetic tests related to Autistic Disorder:

id Genetic test Affiliating Genes
1 Autism Multi-Gene Panels21
2 Autistic Disorder21 SNRPN
3 Autistic Disorder of Childhood Onset23
4 Autism23

Anatomical Context for Autistic Disorder

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Sources:
32LifeMap Discoveryā„¢, 34MalaCards
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MalaCards organs/tissues related to Autistic Disorder:

34
Brain, Eye, Testes, Cortex, Monocytes, Amygdala

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autistic Disorder:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autistic Disorder or affiliated genes

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Sources:
38MGI
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MGI Mouse Phenotypes related to Autistic Disorder:

38
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00030128.2HOXB1, HOXA1, OMG, EN2
2MP:00028737.9HOXB1, HOXA1, OMG, HTR5A, ARX
3MP:00053847.8ARX, EN2, MBD1, HOXA1, HOXB1
4MP:00053767.7HOXA1, OMG, SCT, HTR7, EN2, ARX
5MP:00036317.2HOXB1, HOXA1, SCT, HTR7, MBD1, EN2
6MP:00053866.9ARX, HOXB1, HOXA1, SCT, HTR7, HTR5A

Publications for Autistic Disorder

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Sources:
53PubMed
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Articles related to Autistic Disorder:

(show top 50)    (show all 385)
idTitleAuthorsYear
1
Riluzole as an adjunctive therapy to risperidone for the treatment of irritability in children with autistic disorder: a double-blind, placebo-controlled, randomized trial. (23821414)
2013
2
Psychosocial interventions for reducing vocal challenging behavior in persons with autistic disorder: a multilevel meta-analysis of single-case experiments. (24183495)
2013
3
Phosphatase and tensin homolog (PTEN) gene mutations and autism: literature review and a case report of a patient with Cowden syndrome, autistic disorder, and epilepsy. (21960672)
2012
4
Aripiprazole: in the treatment of irritability associated with autistic disorder in pediatric patients. (21500873)
2011
5
Autistic disorder and phospholipids: A review. (20970971)
2011
6
ASSESSMENT OF DISTRESS IN YOUNG CHILDREN: A COMPARISON OF AUTISTIC DISORDER, DEVELOPMENTAL DELAY, AND TYPICAL DEVELOPMENT. (21647245)
2011
7
Riluzole in autistic disorder. (21823915)
2011
8
Evidence for the involvement of genetic variation in the oxytocin receptor gene (OXTR) in the etiology of autistic disorders on high-functioning level. (19777562)
2010
9
Congenital rubella syndrome with autistic disorder. (20171592)
2010
10
Increased serum levels of high mobility group box 1 protein in patients with autistic disorder. (20302902)
2010
11
Further evidence that the rs1858830 C variant in the promoter region of the MET gene is associated with autistic disorder. (19681062)
2009
12
A placebo-controlled, fixed-dose study of aripiprazole in children and adolescents with irritability associated with autistic disorder. (19797985)
2009
13
Family analysis of immunoglobulin classes and subclasses in children with autistic disorder. (20001993)
2009
14
Prediction of autistic disorder using neuro fuzzy system by applying ANN technique. (18706991)
2008
15
A double-blind placebo controlled trial of piracetam added to risperidone in patients with autistic disorder. (17929164)
2008
16
Ramelteon for insomnia in two youths with autistic disorder. (17069551)
2006
17
Risperidone for autistic disorder. (16216155)
2005
18
The overt aggression scale for rating aggression in outpatient youth with autistic disorder: preliminary findings. (15746480)
2005
19
Neonatal factors in infants with Autistic Disorder and typically developing infants. (16287701)
2005
20
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder. (15652871)
2005
21
Intervention,treatmentand care in autistic disorder. Challenging case reports from northern Finland. (15776994)
2005
22
Characteristics of fetal anticonvulsant syndrome associated autistic disorder. (16108456)
2005
23
Teaching children with attention deficit hyperactivity disorder (ADHD) and autistic disorder (AD) how to swallow pills. (16015399)
2005
24
Deletion 2q37.3 and autism: molecular cytogenetic mapping of the candidate region for autistic disorder. (15517821)
2004
25
High blood monocyte counts and neopterin levels in children with autistic disorder. (12944347)
2003
26
Molecular analysis of the oligodendrocyte myelin glycoprotein gene in autistic disorder. (12566166)
2003
27
Association of INPP1, PIK3CG, and TSC2 gene variants with autistic disorder: implications for phosphatidylinositol signalling in autism. (14627686)
2003
28
Fine mapping of autistic disorder to chromosome 15q11-q13 by use of phenotypic subtypes. (12567325)
2003
29
Smaller left hemisphere planum temporale in adults with autistic disorder. (12147315)
2002
30
Exploring the borderlands of autistic disorder and specific language impairment: a study using standardised diagnostic instruments. (12405479)
2002
31
Molecular genetics and animal models in autistic disorder. (11827743)
2002
32
Long-term treatment with clozapine in an adult with autistic disorder accompanied by aggressive behaviour. (11590976)
2001
33
Association analysis of chromosome 15 gabaa receptor subunit genes in autistic disorder. (12092907)
2001
34
Olanzapine versus haloperidol in children with autistic disorder: an open pilot study. (11501687)
2001
35
Three probands with autistic disorder and isodicentric chromosome 15. (10898916)
2000
36
Brief report: incidence of and risk factors for autistic disorder in neonatal intensive care unit survivors. (10382137)
1999
37
A Double-Blind, Placebo-Controlled Trial of Secretin for the Treatment of Autistic Disorder. (11104404)
1999
38
Physical mapping of the serotonin 5-HT(7) receptor gene (HTR7) to chromosome 10 and pseudogene (HTR7P) to chromosome 12, and testing of linkage disequilibrium between HTR7 and autistic disorder. (10490701)
1999
39
Gastrointestinal abnormalities in children with autistic disorder. (10547242)
1999
40
Mutation screening of the UBE3A/E6-AP gene in autistic disorder. (10089011)
1999
41
The savant syndrome and autistic disorder. (18311109)
1999
42
Chromosome 15q11-13 region and the autistic disorder. (9678411)
1998
43
Sociosexual knowledge, experience, attitudes, and interests of individuals with autistic disorder and developmental delay. (9261666)
1997
44
Sertraline response in adults with mental retardation and autistic disorder. (8778118)
1996
45
Case study: comorbidity among Tourette's syndrome, autistic disorder, and bipolar disorder. (8935216)
1996
46
Season of birth and autistic disorder in Israel. (7726324)
1995
47
Functional deficits in autistic disorder: characterization by technetium-99m-HMPAO and SPECT. (7790938)
1995
48
Depressive and obsessive-compulsive symptoms in hyperserotonemic parents of children with autistic disorder. (8047619)
1994
49
Brief report: cases for an association between Tourette syndrome, autistic disorder, and schizophrenia-like disorder. (8331056)
1993
50
Autistic disorder in Sotos syndrome: a case report. (2347353)
1990

Variations for Autistic Disorder

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Expression for genes affiliated with Autistic Disorder

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Sources:
2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Autistic Disorder

Search GEO for disease gene expression data for Autistic Disorder.

Pathways for genes affiliated with Autistic Disorder

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Sources:
51PathCards, 39NCBI BioSystems Database, 56Reactome, 31KEGG
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Compounds for genes affiliated with Autistic Disorder

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Sources:
30IUPHAR, 46Novoseek, 12DrugBank, 25HMDB, 62Tocris Bioscience, 52PharmGKB, 3BitterDB
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Compounds related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 17)
idCompoundScoreTop Affiliating Genes
1mpdt3010.1HTR5A, HTR7
2[3h]5-ct3010.1HTR5A, HTR7
3emdt3010.1HTR5A, HTR7
48-oh-dpat3010.1HTR5A, HTR7
55-ct3010.1HTR7, HTR5A
65-ht3010.1HTR5A, HTR7
7methiothepin46 3011.0HTR5A, HTR7
8ritanserin46 3011.0HTR5A, HTR7
9metergoline46 3011.0HTR7, HTR5A
10methysergide46 30 1212.0HTR5A, HTR7
11ketanserin46 3011.0HTR5A, HTR7
12Serotonin259.9HTR5A, HTR7
13sumatriptan46 30 62 52 25 1214.9HTR7, HTR5A
14yohimbine46 3 30 1212.8HTR5A, HTR7
15clozapine46 30 52 1212.8HTR5A, HTR7
16risperidone46 52 30 62 25 1214.7HTR7, SCT
17amine469.5HTR7, SCT

GO Terms for genes affiliated with Autistic Disorder

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17Gene Ontology
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Biological processes related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 8)
idNameGO IDScoreTop Affiliating Genes
1serotonin receptor signaling pathwayGO:0072109.8HTR7, HTR5A
2G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGO:0071879.7HTR5A, HTR7
3rhombomere 4 developmentGO:0215709.3HOXA1, HOXB1
4rhombomere 5 developmentGO:0215719.3HOXA1, HOXB1
5facial nucleus developmentGO:0217549.2HOXA1, HOXB1
6facial nerve structural organizationGO:0216129.2HOXA1, HOXB1
7anterior/posterior pattern specificationGO:0099529.1HOXA1, HOXB1
8multicellular organismal developmentGO:0072758.5EN2, HOXA1, HOXB1

Molecular functions related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1serotonin receptor activityGO:0049939.8HTR5A, HTR7
2sequence-specific DNA bindingGO:0435658.0HOXB1, HOXA1, EN2, ARX
3sequence-specific DNA binding transcription factor activityGO:0037007.7ARX, EN2, MBD1, HOXA1, HOXB1

Products for genes affiliated with Autistic Disorder

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autistic Disorder

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4CDC
14ExPASy
15FMA
23GTR
24HGMD
25HMDB
26ICD10
27ICD10 via Orphanet
28ICD9CM
30IUPHAR
31KEGG
36MeSH
37MESH via Orphanet
38MGI
41NCIt
42NDF-RT
45NINDS
46Novoseek
48OMIM
49OMIM via Orphanet
53PubMed
54QIAGEN
60SNOMED-CT via Orphanet
63UMLS
64UMLS via Orphanet