MCID: ATS001
MIFTS: 71

Autistic Disorder malady

Neuronal category

Summaries for Autistic Disorder

Sources:
8Disease Ontology, 34MedlinePlus, 44NINDS, 64Wikipedia, 47OMIM, 33MalaCards
See all sources

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MedlinePlus:34 Autism is a disorder that is usually diagnosed in early childhood. the main signs and symptoms of autism involve communication, social interactions and repetitive behaviors. children with autism might have problems talking with you, or they might not look you in the eye when you talk to them. they may spend a lot of time putting things in order before they can pay attention, or they may say the same sentence again and again to calm themselves down. they often seem to be in their "own world." because people with autism can have very different features or symptoms, health care providers think of autism as a "spectrum" disorder. asperger syndrome is a milder version of the disorder. the cause of autism is not known. autism lasts throughout a person's lifetime. there is no cure, but treatment can help. treatments include behavior and communication therapies and medicines to control symptoms. starting treatment as early as possible is important. nih: national institute of child health and human development

MalaCards: Autistic Disorder, also known as autism, is related to mental retardation and asperger syndrome. An important gene associated with Autistic Disorder is HTR7 (5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled), and among its related pathways are Circadian entrainment and Neural Crest Differentiation. The drugs fenfluramine and risperidone and the compounds mpdt and yohimbine have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and monocytes, and related mouse phenotypes are behavior/neurological and nervous system.

Disease Ontology:8 An autism spectrum disorder that is characterized by symptoms across all three symptom domains (communication, social, restricted repetitive interests and behaviors), delayed language development, and symptom onset prior to age 3 years.

NINDS:44 Autistic disorder (sometimes called autism or classical ASD) is the most common condition in a group of developmental disorders known as the autism spectrum disorders (ASDs).

Wikipedia:64 Autism is a disorder of neural development characterized by impaired social interaction and verbal and... more...

Description from OMIM:47 613436, 300496, 608636, 300830, 613410 209850, 300495, 300425, 612100, 611913 more

Aliases & Classifications for Autistic Disorder

Sources:
8Disease Ontology, 20GeneTests, 10DISEASES, 31LifeMap Discovery™, 61UMLS, 22GTR, 44NINDS, 34MedlinePlus, 45Novoseek, 57SNOMED-CT, 47OMIM, 35MeSH, 27ICD9CM, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Neuronal


Aliases & Descriptions:

autistic disorder 8 20 10 31 61
autism 8 20 22 44 34
autistic disorder of childhood onset 8 22
infantile psychosis 8 61
kanner's syndrome 8
infantile autism 8
childhood autism 8
autistic 45


Related Diseases for Autistic Disorder

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Autistic Disorder via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 347)
idRelated DiseaseScoreTop Affiliating Genes
1mental retardation30.6NLGN3, UBE3A, ARX, HOXA1, ADSL
2asperger syndrome30.1NLGN3, NLGN4Y
3rett syndrome29.9DLX5, UBE3A
4developmental disabilities10.6
5adult syndrome10.5
6attention deficit hyperactivity disorder10.4
7angelman syndrome10.3
8autism susceptibility 1510.3
9autism susceptibility 1610.3
10autism susceptibility 1710.2
11autism 1810.2
12autism susceptibility, x-linked 210.2
13autism susceptibility, x-linked 110.2
14autism susceptibility, x-linked 310.2
15autism x-linked 510.2
16young syndrome10.2
17obsessive-compulsive disorder10.2
18anxiety disorder10.2
19bipolar disorder10.2
20alexithymia10.2
21conduct disorder10.2
22echolalia10.2
23micro syndrome10.2
24epsilon-trimethyllysine hydroxylase deficiency10.2
25neurofibromatosis10.2
26macrocephaly/autism syndrome10.2
27smith-lemli-opitz syndrome10.1
28prader-willi syndrome10.1
29brain disease10.1
30charge syndrome10.1
31mental retardation epilepsy10.1
32autism susceptibility 110.1
33autism 1010.1
34asperger syndrome susceptibility, x-linked 210.1
35asperger syndrome susceptibility, x-linked 110.1
36rubella10.1
37autism spectrum disorder10.1
38speech disorder10.1
39childhood-onset schizophrenia10.1
40cytomegalovirus infection10.1
41mental retardation with language impairment and autistic features10.1
42borna disease10.1
43lyme disease10.1
44mutism10.1
45megalencephaly10.1
46seizure disorder10.1
47autism 1910.1
48cohen syndrome10.1
49bruxism10.0
50joubert syndrome10.0

Graphical network of the top 20 diseases related to Autistic Disorder:



Diseases related to autistic disorder

Clinical Features for Autistic Disorder

Sources:
47OMIM
See all sources

Clinical features from OMIM:

613436,300496,608636,300830,613410,209850,300495,300425,612100,611913

Drugs & Therapeutics for Autistic Disorder

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 31LifeMap Discovery™, 61UMLS, 41NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Autistic Disorder

Drug clinical trials:

Search ClinicalTrials for Autistic Disorder

Search NIH Clinical Center for Autistic Disorder

Search CenterWatch for Autistic Disorder

Inferred drug relations via UMLS61/NDF-RT41:

Cell-based therapeutics:


LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine
Read about Autistic Disorder cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Autistic Disorder:
NU211-01/NC215-01, human umbilical cord mesenchymal stem cells for patients with autism
Embryonic/Adult Cultured Cells Related to Autistic Disorder:
Umbilical cord-derived mesenchymal stem cells
Umbilical cord blood-derived mononuclear cells

Genetic Tests for Autistic Disorder

Sources:
20GeneTests, 22GTR
See all sources

Genetic tests related to Autistic Disorder:

id Genetic test Affiliating Genes
1 Autism Multi-gene Panels20
2 Autistic Disorder20 SNRPN
3 Autistic Disorder Of Childhood Onset22
4 Autism22

Anatomical Context for Autistic Disorder

Sources:
31LifeMap Discovery™, 33MalaCards
See all sources

MalaCards organs/tissues related to Autistic Disorder:

33
Brain, Cortex, Monocytes, T cells, Fetal brain, Cingulate cortex, Temporal lobe, Occipital lobe, Amygdala, Adrenal cortex

LifeMap Discovery
The database of embryonic development, stem cell research and regenerative medicine

Cells/anatomical compartments in embryo or adult related to Autistic Disorder:
id TissueAnatomical CompartmentCell Relevance
1 Umbilical CordWharton's JellyMesenchymal Stem Cells Potential therapeutic candidate

Animal Models for Autistic Disorder or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Autistic Disorder

Sources:
51PubMed
See all sources

Articles related to Autistic Disorder:

(show top 50)    (show all 443)
idTitleAuthorsYear
1
Are autistic traits measured equivalently in individuals with and without an autism spectrum disorder? An invariance analysis of the autism spectrum quotient short form. (23695223)
2014
2
Brief Report: Pilot Single-Blind Placebo Lead-In Study of Acamprosate in Youth with Autistic Disorder. (24052275)
2013
3
Prodromal and autistic symptoms in schizotypal personality disorder and 22q11.2 deletion syndrome. (22686870)
2013
4
Epidemiology of autistic disorder in Bahrain: prevalence and obstetric and familial characteristics. (24313037)
2013
5
Psychometric properties of the Parenting Stress Index with parents of children with autistic disorder. (23701497)
2013
6
Parental perspectives on use, benefits, and physician knowledge of complementary and alternative medicine in children with autistic disorder and attention-deficit/hyperactivity disorder. (23621389)
2013
7
Is long-term prognosis for pervasive developmental disorder not otherwise specified different from prognosis for autistic disorder? Findings from a 30-year follow-up study. (21713590)
2012
8
Day and nighttime excretion of 6-sulphatoxymelatonin in adolescents and young adults with autistic disorder. (22613035)
2012
9
Aripiprazole: in the treatment of irritability associated with autistic disorder in pediatric patients. (21500873)
2011
10
Safety and tolerability of aripiprazole for irritability in pediatric patients with autistic disorder: a 52-week, open-label, multicenter study. (21813076)
2011
11
A MECP2 missense mutation within the MBD domain in a Brazilian male with autistic disorder. (21600714)
2011
12
Double-blind, placebo-controlled trial of risperidone plus topiramate in children with autistic disorder. (20637249)
2010
13
Global methylation profiling of lymphoblastoid cell lines reveals epigenetic contributions to autism spectrum disorders and a novel autism candidate gene, RORA, whose protein product is reduced in autistic brain. (20375269)
2010
14
Developmental milestones in toddlers with autistic disorder, pervasive developmental disorder--not otherwise specified and atypical development. (20629590)
2010
15
Timing of increased autistic disorder cumulative incidence. (20158232)
2010
16
Family analysis of immunoglobulin classes and subclasses in children with autistic disorder. (20001993)
2009
17
Prediction of autistic disorder using neuro fuzzy system by applying ANN technique. (18706991)
2008
18
Symptomatic nutritional rickets in a teenager with autistic spectrum disorder. (18257797)
2008
19
Control of psychomotor agitation and aggressive behavior in patients with autistic disorder: a retrospective chart review. (18949256)
2008
20
Spotlight on risperidone in irritability associated with autistic disorder in children and adolescents. (18278980)
2008
21
Risperidone: a review of its use in the treatment of irritability associated with autistic disorder in children and adolescents. (17927305)
2007
22
Risperidone-induced enuresis in two children with autistic disorder. (17822346)
2007
23
Ramelteon for insomnia in two youths with autistic disorder. (17069551)
2006
24
Migration abnormality in the left cingulate gyrus presenting with autistic disorder. (16970852)
2006
25
Low-dose venlafaxine in three adolescents and young adults with autistic disorder improves self-injurious behavior and attention deficit/hyperactivity disorders (ADHD)-like symptoms. (16307837)
2006
26
Porphyrinuria in childhood autistic disorder: implications for environmental toxicity. (16782144)
2006
27
Risperidone treatment of autistic disorder: longer-term benefits and blinded discontinuation after 6 months. (15994720)
2005
28
Examining the relationship between executive functions and restricted, repetitive symptoms of Autistic Disorder. (16134030)
2005
29
Gastrointestinal factors in autistic disorder: a critical review. (16267642)
2005
30
Deletion 2q37.3 and autism: molecular cytogenetic mapping of the candidate region for autistic disorder. (15517821)
2004
31
De novo translocation t(5;18)(q33.1;q12.1) associated with autistic disorder. (15266626)
2004
32
Should autistic children be evaluated for mitochondrial disorders? (15224710)
2004
33
Autistic disorder in nineteenth-century London: three case reports. (15070544)
2004
34
Sensory-motor deficits in children with developmental coordination disorder, attention deficit hyperactivity disorder and autistic disorder. (15541530)
2004
35
The effect of a switch to ziprasidone in an adult population with autistic disorder: chart review of naturalistic, open-label treatment. (14744179)
2004
36
Autistic disorder and chromosomal mosaicism 46,XY[123]/46,XY,del(20)(pter --> p12.2)[10]. (12884434)
2003
37
No association between the EN2 gene and autistic disorder. (12525552)
2003
38
Association study of autistic disorder and chromosome 16p. (12749074)
2003
39
Smaller left hemisphere planum temporale in adults with autistic disorder. (12147315)
2002
40
Phenotypic homogeneity provides increased support for linkage on chromosome 2 in autistic disorder. (11875756)
2002
41
Some aspects of treatment and habilitation of children and adolescents with autistic disorder in Northern-Finland. (12585822)
2002
42
Clomipramine versus haloperidol in the treatment of autistic disorder: a double-blind, placebo-controlled, crossover study. (11476129)
2001
43
Assessment in multisite randomized clinical trials of patients with autistic disorder: the Autism RUPP Network. Research Units on Pediatric Psychopharmacology. (10832774)
2000
44
A comparison of social skills in adults with autistic disorder, pervasive developmental disorder not otherwise specified, and mental retardation. (10478728)
1999
45
Case study: anorexia nervosa and autistic disorder in an adolescent girl. (8768355)
1996
46
Brief report: an autistic male presenting seasonal affective disorder (SAD) and trichotillomania. (7814314)
1994
47
Abnormalities of chromosome 18 in a girl with mental retardation and autistic disorder. (8334323)
1993
48
Clonidine treatment of hyperactive and impulsive children with autistic disorder. (1479049)
1992
49
Toward DSM-IV: a developmental approach to autistic disorder. (2047332)
1991
50
Fluvoxamine treatment of coincident autistic disorder and obsessive-compulsive disorder: a case report. (2126264)
1990

Genetic Variations for Autistic Disorder

Expression for genes affiliated with Autistic Disorder

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Autistic Disorder

Search GEO for disease gene expression data for Autistic Disorder.

Pathways for genes affiliated with Autistic Disorder

Sources:
30KEGG, 38NCBI BioSystems Database, 54Reactome, 12EMD Millipore, 53R&D Systems
See all sources

Compounds for genes affiliated with Autistic Disorder

Sources:
29IUPHAR, 45Novoseek, 2BitterDB, 11DrugBank, 60Tocris Bioscience, 50PharmGKB, 24HMDB
See all sources

Compounds related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 15)
idCompoundScoreTop Affiliating Genes
1mpdt2910.7HTR7, HTR5A
2yohimbine45 29 2 1113.7HTR7, HTR5A, TAS2R1
3[3h]5-ct2910.7HTR7, HTR5A
4emdt2910.7HTR5A, HTR7
5gaba4510.7DLX5, ARX, GABRA5, SCT, UBE3A
68-oh-dpat2910.7HTR5A, HTR7
75-ct2910.7HTR7, HTR5A
8methiothepin45 2911.6HTR5A, HTR7
9ritanserin29 4511.6HTR5A, HTR7
105-ht2910.6HTR5A, HTR7
11metergoline45 2911.5HTR7, HTR5A
12methysergide45 29 1112.5HTR5A, HTR7
13sumatriptan45 29 60 50 11 2415.5HTR5A, HTR7
14ketanserin29 4511.4HTR5A, HTR7
15benzodiazepine4510.1PER1, UBE3A

GO Terms for genes affiliated with Autistic Disorder

Sources:
16Gene Ontology
See all sources

Cellular components related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell junctionGO:03005410.4GABRA5, NLGN3, NLGN2, NLGN4Y
2integral to plasma membraneGO:00588710.3GABRA5, HTR5A, HTR7, NLGN3, NLGN2, NLGN4Y
3synapseGO:04520210.1NLGN4Y, NLGN2, NLGN3

Biological processes related to Autistic Disorder according to GeneCards/GeneDecks:

(show all 16)
idNameGO IDScoreTop Affiliating Genes
1rhombomere 4 developmentGO:02157010.7HOXA1, HOXB1
2facial nucleus developmentGO:02175410.7HOXB1, HOXA1
3rhombomere 5 developmentGO:02157110.7HOXB1, HOXA1
4facial nerve structural organizationGO:02161210.7HOXB1, HOXA1
5synapse assemblyGO:00741610.7NLGN3, NLGN2, NLGN4Y
6postsynaptic membrane assemblyGO:09710410.7NLGN3, NLGN2
7anatomical structure formation involved in morphogenesisGO:04864610.7DLX5, HOXB1
8presynaptic membrane assemblyGO:09710510.6NLGN3, NLGN2
9serotonin receptor signaling pathwayGO:00721010.6HTR7, HTR5A
10positive regulation of excitatory postsynaptic membrane potentialGO:200046310.6NLGN3, NLGN2
11neuron cell-cell adhesionGO:00715810.6NLGN3, NLGN2
12regulation of respiratory gaseous exchange by neurological system processGO:00208710.5NLGN2, NLGN3
13cochlea developmentGO:09010210.4HOXA1, GABRA5
14positive regulation of transcription from RNA polymerase II promoterGO:04594410.4EN2, WNT2, HOXA1, HOXB1, UBE3A
15positive regulation of synaptic transmission, glutamatergicGO:05196810.3NLGN2, NLGN3
16positive regulation of synapse assemblyGO:05196510.1NLGN3, NLGN2

Molecular functions related to Autistic Disorder according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cell adhesion molecule bindingGO:05083910.4NLGN3, NLGN2
2neurexin family protein bindingGO:04204310.4NLGN3, NLGN2, NLGN4Y
3receptor activityGO:00487210.3NLGN4Y, NLGN2, NLGN3, GABRA5
4serotonin receptor activityGO:00499310.2HTR5A, HTR7

Products for genes affiliated with Autistic Disorder

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Autistic Disorder

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet